U.S. No Longer Superpower: Velayati
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Telomere Length Shortening in Microglia: Implication for Accelerated Senescence and Neurocognitive Deficits in HIV
Article Telomere Length Shortening in Microglia: Implication for Accelerated Senescence and Neurocognitive Deficits in HIV Chiu-Bin Hsiao 1, Harneet Bedi 2, Raquel Gomez 2, Ayesha Khan 2, Taylor Meciszewski 2, Ravikumar Aalinkeel 2, Ting Chean Khoo 3, Anna V. Sharikova 3, Alexander Khmaladze 3 and Supriya D. Mahajan 2,* 1 Medicine Institute, School of Medicine, Infectious Diseases, Drexel University, Positive Health Clinic, Allegheny General Hospital, Allegheny Health Network, Pittsburgh, PA 15212, USA; [email protected] 2 Department of Medicine, Division of Allergy, Immunology & Rheumatology, University at Buffalo’s Clinical Translational Research Center, Buffalo, NY 14203, USA; [email protected] (H.B.); [email protected] (R.G.); [email protected] (A.K.); [email protected] (T.M.); [email protected] (R.A.) 3 Department of Physics, University at Albany SUNY, Albany, NY 12222, USA; [email protected] (T.C.K.); [email protected] (A.V.S.); [email protected] (A.K.) * Correspondence: [email protected]; Tel.: +1-1-716-888-4776 Abstract: The widespread use of combination antiretroviral therapy (cART) has led to the accelerated aging of the HIV-infected population, and these patients continue to have a range of mild to moderate HIV-associated neurocognitive disorders (HAND). Infection results in altered mitochondrial function. The HIV-1 viral protein Tat significantly alters mtDNA content and enhances oxidative stress in immune cells. Microglia are the immune cells of the central nervous system (CNS) that exhibit Citation: Hsiao, C.-B.; Bedi, H.; a significant mitotic potential and are thus susceptible to telomere shortening. HIV disrupts the Gomez, R.; Khan, A.; Meciszewski, T.; normal interplay between microglia and neurons, thereby inducing neurodegeneration. -
Iran Case File (April 2021)
IRAN CASE FILE April 2021 RASANAH International Institute for Iranian Studies, Al-Takhassusi St. Sahafah, Riyadh Kingdom of Saudi Arabia. P.O. Box: 12275 | Zip code: 11473 Contact us [email protected] +966112166696 Executive Summary .....................................................................................4 Internal Affairs ........................................................................................... 7 The Ideological File .............................................................................................8 1. Women and the “Political Man” ............................................................................... 8 2. Khatami and the Position of Women ......................................................................10 The Political File ............................................................................................... 12 1. The Most Notable Highlights of the Leaked Interview .............................................12 2. Consequences and Reactions .................................................................................13 3. The Position of the Iranian President and Foreign Ministry on the Interview ..........14 4. The Implications of Leaking the Interview at This Time..........................................15 The Economic File ............................................................................................. 16 1. Bitcoin’s Genesis Globally and the Start of Its Use in Iran ........................................16 2. The Importance of Bitcoin for Iran -
Fructose Causes Liver Damage, Polyploidy, and Dysplasia in the Setting of Short Telomeres and P53 Loss
H OH metabolites OH Article Fructose Causes Liver Damage, Polyploidy, and Dysplasia in the Setting of Short Telomeres and p53 Loss Christopher Chronowski 1, Viktor Akhanov 1, Doug Chan 2, Andre Catic 1,2 , Milton Finegold 3 and Ergün Sahin 1,4,* 1 Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA; [email protected] (C.C.); [email protected] (V.A.); [email protected] (A.C.) 2 Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA; [email protected] 3 Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA; fi[email protected] 4 Department of Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA * Correspondence: [email protected]; Tel.: +1-713-798-6685; Fax: +1-713-798-4146 Abstract: Studies in humans and model systems have established an important role of short telomeres in predisposing to liver fibrosis through pathways that are incompletely understood. Recent studies have shown that telomere dysfunction impairs cellular metabolism, but whether and how these metabolic alterations contribute to liver fibrosis is not well understood. Here, we investigated whether short telomeres change the hepatic response to metabolic stress induced by fructose, a sugar that is highly implicated in non-alcoholic fatty liver disease. We find that telomere shortening in telomerase knockout mice (TKO) imparts a pronounced susceptibility to fructose as reflected in the activation of p53, increased apoptosis, and senescence, despite lower hepatic fat accumulation in TKO mice compared to wild type mice with long telomeres. The decreased fat accumulation in TKO Citation: Chronowski, C.; Akhanov, is mediated by p53 and deletion of p53 normalizes hepatic fat content but also causes polyploidy, V.; Chan, D.; Catic, A.; Finegold, M.; Sahin, E. -
Airborne Firefighting System Unveiled
WWW.TEHRANTIMES.COM I N T E R N A T I O N A L D A I L Y 16 Pages Price 20,000 Rials 1.00 EURO 4.00 AED 39th year No.13218 Sunday SEPTEMBER 30, 2018 Mehr 8, 1397 Muharram 20, 1440 ‘Guards of revolution’ Moscow will not allow Louis van Gaal to “Alphabet” picked as will come hard on sending terrorists from replace Carlos Queiroz best animation at enemies like thunder 2 Syria to Afghanistan 3 as Iran coach? 15 New York festival 16 Integrated Trade System unveiled ECONOMY TEHRAN— Iran’s In- The system seeks to facilitate trade desktegrated Trade System procedures for Iranian businessmen and was unveiled on Saturday in the presence combat trafficking of strategic goods be- Airborne firefighting of Iran’s ministers of Industry, Mining sides systematic corruption, the report and Trade Mohammad Shariatmadari and quoted an official from the industry that of Information and Communications ministry, Behnam Amiri, as announc- Technology (ICT) Mohammad-Javad Azari ing addressing the unveiling ceremony See page 12 Jahromi, IRNA reported. of the system at the Tehran Permanent The system includes the comprehensive trade International Fairgrounds. system unveiled system, goods identification system, integrated As Amiri hoped, the integrated system system of warehouses, validation system and will bring acceleration, ease, and trans- credit rating system of the merchants. parency into domestic trade transactions. Zarif meets counterparts in New York POLITICS TEHRAN — Iranian Stef Blok, the Austrian and Dutch foreign deskForeign Minister Mo- ministers, Zarif discussed the need to pre- hammad Javad Zarif met separately with serve the 2015 nuclear deal after the U.S. -
Telomere-To-Telomere Assembly of a Complete Human X Chromosome W
https://doi.org/10.1038/s41586-020-2547-7 Accelerated Article Preview Telomere-to-telomere assembly of a W complete human X chromosome E VI Received: 30 July 2019 Karen H. Miga, Sergey Koren, Arang Rhie, Mitchell R. Vollger, Ariel Gershman, Andrey Bzikadze, Shelise Brooks, Edmund Howe, David Porubsky, GlennisE A. Logsdon, Accepted: 29 May 2020 Valerie A. Schneider, Tamara Potapova, Jonathan Wood, William Chow, Joel Armstrong, Accelerated Article Preview Published Jeanne Fredrickson, Evgenia Pak, Kristof Tigyi, Milinn Kremitzki,R Christopher Markovic, online 14 July 2020 Valerie Maduro, Amalia Dutra, Gerard G. Bouffard, Alexander M. Chang, Nancy F. Hansen, Amy B. Wilfert, Françoise Thibaud-Nissen, Anthony D. Schmitt,P Jon-Matthew Belton, Cite this article as: Miga, K. H. et al. Siddarth Selvaraj, Megan Y. Dennis, Daniela C. Soto, Ruta Sahasrabudhe, Gulhan Kaya, Telomere-to-telomere assembly of a com- Josh Quick, Nicholas J. Loman, Nadine Holmes, Matthew Loose, Urvashi Surti, plete human X chromosome. Nature Rosa ana Risques, Tina A. Graves Lindsay, RobertE Fulton, Ira Hall, Benedict Paten, https://doi.org/10.1038/s41586-020-2547-7 Kerstin Howe, Winston Timp, Alice Young, James C. Mullikin, Pavel A. Pevzner, (2020). Jennifer L. Gerton, Beth A. Sullivan, EvanL E. Eichler & Adam M. Phillippy C This is a PDF fle of a peer-reviewedI paper that has been accepted for publication. Although unedited, the Tcontent has been subjected to preliminary formatting. Nature is providing this early version of the typeset paper as a service to our authors and readers. The text andR fgures will undergo copyediting and a proof review before the paper is published in its fnal form. -
BIOTECH Basics of Each Chromosome Are Repeating Sequences of DNA Known As Telomeres
What You Need to Know n DNA is organized into small structures known as chromosomes. At the ends BIOTECH Basics of each chromosome are repeating sequences of DNA known as telomeres. n Every time the cell divides and copies its DNA, the very end of the telomere is unable to be copied and the total telomere length is shortened. n Telomeres act as a buffer to protect the genes near the ends of the chro- mosome from being degraded by the Telomeres shortening process. the aglets of the genomic world n When the telomeres become too short, the cell stops dividing. This is called senescence and is associated hink about your fa- times. Telomere length varies between with aging. Tvorite pair of lace- individuals and across cell type but there up shoes. Focus on the may be as many as 15,000 nucleotides at n An enzyme known as telomerase is active in a small number of cells to keep shoelaces from those shoes, specifically the tip of a chromosome. telomeres long. Most adult cells have on the tips where the small plastic or met- When a cell divides, the chromosomes no telomerase present. al coverings wrap around the lace. Those are copied by specific enzymes and pro- coverings, known as aglets, protect the vide each daughter cell with a complete n There seems to be a link between long telomeres and longevity. Possibly ends from damage and keep the fibers set of genetic information. Unfortunately, those individuals who live long lives are of the lace from unraveling. If the aglet the copying enzymes are unable to com- producing a very low level of telom- wears away, the end becomes frayed and pletely reproduce the very end of each erase in their adult cells. -
Understanding the Role of State Identity in Foreign Policy Decision-Making
The London School of Economics and Political Science UNDERSTANDING THE ROLE OF STATE IDENTITY IN FOREIGN POLICY DECISION-MAKING The Rise and Demise of Saudi–Iranian Rapprochement (1997–2009) ADEL ALTORAIFI A thesis submitted to the Department of International Relations of the London School of Economics and Political Science for the degree of Doctor of Philosophy London, October 2012 1 To Mom and Dad—for everything. 2 DECLARATION I certify that the thesis I have presented for examination for the PhD degree of the London School of Economics and Political Science is solely my own work. The copyright of this thesis rests with the author. Quotation from it is permitted, provided that full acknowledgement is made. This thesis may not be reproduced without the prior written consent of the author. I warrant that this authorization does not, to the best of my belief, infringe the rights of any third party. The final word count of this thesis, including titles, footnotes and in-text citations, is 105,889 words. 3 ABSTRACT The objective of the thesis is to study the concept of state identity and its role in foreign policy decision-making through a constructivist analysis, with particular focus on the Saudi–Iranian rapprochement of 1997. While there has been a recent growth in the study of ideational factors and their effects on foreign policy in the Gulf, state identity remains understudied within mainstream International Relations (IR), Foreign Policy Analysis (FPA), and even Middle Eastern studies literature, despite its importance and manifestation in the region’s foreign policy discourses. The aim is to challenge purely realist and power-based explanations that have dominated the discourse on Middle Eastern foreign policy—and in particular, the examination of Saudi–Iranian relations. -
Army to Hold War Game on Thursday Volleyball Club Niš Are a Professional Volleyball Team Based in Niš, Serbia and Play in the Serbian Volley League
WWW.TEHRANTIMES.COM I N T E R N A T I O N A L D A I L Y 8 Pages+4 Price 50,000 Rials 1.00 EURO 4.00 AED 42nd year No.13757 Thursday SEPTEMBER 10, 2020 Shahrivar 20, 1399 Muharram 21, 1442 Senator Murphy calls Skocic talks about Condensate Tehran academic center Pompeo’s remarks on Iran’s his footballing output reaches picks “Les Misérables” for uranium stockpile funny 2 dreams 3 650,000 bpd 4 book reading contest 8 Iran slams West’s hypocrisy on freedom SPECIAL ISSUE of expression TEHRAN — In an indirect reference to the republication of cartoons insulting the Holy Prophet of Islam (PBUH) by the French satirical magazine Charlie Hebdo, Foreign Minister Mohammad Javad Zarif Conspiracy on Wednesday slammed “institutional- ized hypocrisy” under the pretext of the freedom of expression. “Freedom of Expression? Or Institutionalized Hypocrisy? 2 Steel ingot output or not? increases 7% in 5 months yr/yr TEHRAN — Production of steel ingot in Iran increased seven percent during the first five months of the current Irani- an calendar year (March 20-August 21) compared to the same period of time in the past year, IRNA reported. As reported, over 9.238 million tons of steel ingot was produced during the five- month period of the present year. 4 Designs from Iran shortlisted for Dezeen Awards 2020 By Seyyed Mostafa Mousavi Sabet TEHRAN — Designs of the Nur-e Mobin Primary School and the Kohan Ceram Central Office created by Iranian archi- File photo tects have been shortlisted for the Dezeen Awards 2020 in London. -
Aktuelle Hinweise Iran 01.09.2014
01. September 2014 Aktuelle Hinweise IRAN: Non-oil exports up by 20.83% in first 5 months of the Iranian year. Trade volume reaches USD 41 billion and 620 million As per the latest figures released by the Islamic Republic of Iran Customs Administration USD 19 billion and 639 million of goods have been exported and USD 21 billion and 981 million of goods have been imported into the country during the first five months of the Iranian calendar year (starting March 21, 2014). The data show an increase of 20.83% for non-oil exports and of 33.59% for imports compared to the same time last year. The largest shares of goods were imported from Iran by China, Iraq, UAE, Afghanistan and India. The main Iranian export products included liquefied propane, liquefied methanol and butane. The goods Iran imported most of were wheat with a share of 4.97%, vehicles with internal combustion piston engine (more than 1500cc) with 3.66%, rice with 3.47%, corn with 2.63%, and soy meal with 2.42%. The main exporters of goods to Iran were UAE, China, India, South Korea and Turkey respectively. Indigenous automobile production reaches 400k in five months The Iranian automobile production has reached about 405,000 during the first five months of the Iranian calendar year (beginning on March 21, 2014). This corresponds with an increase of 74.3% compared to the same time last year. Eight different automobile models were mainly produced by Iran’s two largest manufacturers SAIPA (Société Anonyme Iranienne de Production Automobile) and IKCO (Iran Khodro). -
The Biology of Telomere Chromatin in Stem Cells and Cancers Dr
The Biology of Telomere Chromatin in Stem cells and Cancers Dr. Lee Wong www.scientiapublications.com Principles and Biomedical The Biology of Telomere Chromatin implications of the Chromatin in Stem cells and Cancers Dr. Lee Wong is a molecular biologist at Monash University, who has been studying the mechanisms regulating the role of specific chromosomal Regulation of Telomere Integrity structures known as telomeres in enabling stem cells and cancer cells to develop and replicate. The work has implications for anti-cancer and Telomere length is directly linked to the ability of stem cells and cancer cells to live and replicate infinitely. Here we discuss the principle stem-cell based therapies. in light of the findings of Dr. Wong on the role of H3.3 histone protein and its chaperone ATRX on maintaining telomere integrity, and their possible therapeutic implications. TELOMERE FUNCTION IN CELL BIOLOGY renewal. Chromosomes are not typically found on their own in the nucleus, but are The DNA held within the nuclei of our cells rather complexed with structural proteins. is packaged and arranged in biological The chromosomal DNA-protein complexes structures known as the chromosomes. The are termed chromatins. One of the chief latter carry all the genes necessary to control proteins that are found in close association the various functions performed by the with chromosomal DNA is known as histones. cell. During cell division, our chromosomes The latter has been found to play a major role undergo duplication, a process undertaken by in controlling the integrity and stability of specialized DNA-building enzymes to ensure telomeres. -
How Rouhani's Government Exploits US ﻋﻧوان اﻟﻣوﺿوع : Sanctions T
Filling the Void : ωϭοϭϣϟϡγ How Rouhani¶s Government Exploits US : ωϭοϭϣϟϥϭϧϋ Sanctions to Enhance its Position 04/11/2018 : έηϧϟΦϳέΎΗ ΔϣΩϘΗϣϟΕΎγέΩϟϭΙΎΣΑϸϟϝΑϘΗγϣϟίϛέϣ : ΏΗΎϛϟϡγ : ωϭοϭϣϟ 9/28/2021 10:13:19 AM 1 / 2 With the second batch of US sanctions on Iran, coming into effect today, the government of President Hassan Rouhani is taking preemptive measures to strengthen its ability to confront sanctions. It seeks to exploit the sanctions to endorse its candidates for the four ministerial portfolios whose ministers were dismissed in the past months, following a no-confidence vote in the Consultative Assembly.But this move does not mark the beginning of a lull between the government, backed by the moderates, and its opponents from the fundamentalist conservatives and some religious leaders, as well as the powerful institutions, such as the Islamic Revolutionary Guard Corps (IRGC). This period seems temporary, in anticipation of the outcome of the new sanctions in the coming period. Numerous JustificationsPresident Hassan Rouhani quickly issued a decree on October 28, 2018, appointing the four ministers to their posts after they gained the confidence of the Consultative Assembly. The timing of the decree has, of course, a significance. The government exploited the approaching sanctions to promote the need for filling the void ensuing from the dismissal of four ministers by the Consultative Assembly, which severely criticized them for failing to handle the various crises, in a way that led - in the view of fundamentalist conservatives -
1. Scope of Document
IRAN COUNTRY REPORT October 2004 Country Information & Policy Unit IMMIGRATION AND NATIONALITY DIRECTORATE HOME OFFICE, UNITED KINGDOM Iran Country Report October 2004 CONTENTS 1 Scope of Document 1.1 - 1.10 2 Geography 2.1 - 2.2 3 Economy 3.1 - 3.10 4 History 4.1 Pre - 1979 4.2 - 4.3 1979 - 1989 4.4 - 4.6 1990 - 1996 4.7 - 4.9 1997 - 1999 4.10 - 4.14 2000 4.15 - 4.17 2001 onwards 4.18 - 4.23 Student Unrest - June 2003 4.24 - 4.29 Parliamentary Elections - February 2004 4.30 - 4.33 5 State Structures The Constitution 5.1 Citizenship and Nationality 5.2 - 5.4 Political System 5.5 - 5.7 Political Parties 5.8 - 5.13 Judiciary 5.14 - 5.31 Court Documentation 5.32 - 5.34 Legal Rights and Detention 5.35 - 5.41 Death Penalty 5.42 - 5.45 Internal Security 5.46 - 5.52 Prisons and Prison Conditions 5.53 - 5.59 Military Service 5.60 - 5.62 Medical Services 5.63 Drugs 5.64 Drug Addiction 5.65 - 5.66 Psychiatric Treatment 5.67 - 5.69 HIV/AIDS 5.70 - 5.72 People with Disabilities 5.73 Educational System 5.74 - 5.77 6 Human Rights 6.A Human Rights issues General 6.1 - 6.14 Freedom of Speech and the Media 6.15 - 6.25 Press Law 6.26 - 6.40 Internet and Satellite 6.41 - 6.45 Freedom of Religion 6.46 - 6.52 Legal Framework 6.53 - 6.54 Sunni Muslims 6.55 Christians 6.56 - 6.58 Apostasy/Conversions 6.59 - 6.62 Jews 6.63 - 6.65 Zoroastrians 6.66 - 6.67 Sabeans (Mandeans) 6.68 Baha'is 6.69 - 6.82 Freedom of Assembly and Association 6.83 - 6.90 Employment Rights 6.91 - 6.95 People Trafficking 6.96 Freedom of Movement 6.97 - 6.106 Refugees in Iran 6.107 - 6.112