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Efficacy of a Mouthwash Containing 0.8% Arginine, PVM/MA Copolymer

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Efficacy of a Mouthwash Containing 0.8% Arginine, PVM/MA Copolymer View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Elsevier - Publisher Connector j o u r n a l o f d e n t i s t r y 4 1 s ( 2 0 1 3 ) s 2 6 – s 3 3 Available online at www.sciencedirect.com journal homepage: www.intl.elsevierhealth.com/journals/jden Efficacy of a mouthwash containing 0.8% arginine, PVM/MA copolymer, pyrophosphates, and 0.05% sodium fluoride compared to a negative control mouthwash on dentin hypersensitivity reduction. A randomized clinical trial a, b b b b Deyu Hu *, Bernal Stewart , Sarita Mello , Lia Arvanitidou , Foti Panagakos , b b c a William De Vizio , Yun Po Zhang , Luis R. Mateo , Wei Yin a Department of Preventive Dentistry, College of Stomatology, West China University of Medial Sciences, Chengdu, China b Colgate-Palmolive Technology Center, Piscataway, NJ, USA c LRM Statistical Consulting LLC, USA a r t i c l e i n f o a b s t r a c t Article history: Objective: The objective of this eight week, single-center, two-cell, double-blind, and ran- Received 19 June 2012 domized clinical study was to evaluate the dentin hypersensitivity reduction efficacy of a TM Received in revised form mouthwash using Pro-Argin Mouthwash Technology containing 0.8% arginine, PVM/MA 24 August 2012 copolymer, pyrophosphates, and 0.05% sodium fluoride in an alcohol-free base (‘‘Arginine Accepted 1 October 2012 Mouthwash’’) compared to an ordinary mouthwash without any active ingredients (‘‘Nega- tive Control’’). Methods: Qualifying subjects who presented two hypersensitive teeth with a tactile hyper- Keywords: sensitivity score between 10 and 50 g of force, and an air blast hypersensitivity score of 2 or 3 Efficacy participated in this study and were randomized into one of two treatment groups. Subjects Dentinal brushed with the toothbrush and fluoride toothpaste provided and then rinsed with 20 mL of Hypersensitivity their assigned mouthwash for 30 s twice daily. Subjects refrained from eating or drinking for Mouthwash 30 min after rinsing. Dentin hypersensitivity assessments, as well as examinations of oral Tactile hard and soft tissues, were conducted at the baseline visit and again after two weeks, four weeks and eight weeks of product use. Air Blast Results: Ninety (90) subjects entered and completed the eight week study. After two weeks, four weeks and eight weeks of product use, subjects in the Arginine Mouthwash group exhibited statistically significant ( p < 0.05) improvements in mean tactile and air blast hypersensitivity scores as compared to the Negative Control Mouthwash. Conclusion: The results of this study support the conclusion that the Arginine Mouthwash provides a significant reduction in dentin hypersensitivity after eight weeks of product use as compared to a Negative Control mouthwash. # 2012 Elsevier Ltd. Open access under CC BY-NC-ND license. articles have ranged from discussions of its causes and 1. Introduction management to current and new agents that have been incorporated into oral health product formulations Dentin hypersensitivity has been the subject of many which have been clinically proven to treat dentin hyper- 1–8 scientific publications over the past several years. The sensitivity. * Corresponding author. Tel.: +86 285582167. E-mail address: [email protected] (D. Hu). 0300-5712 # 2012 Elsevier Ltd. Open access under CC BY-NC-ND license. http://dx.doi.org/10.1016/j.jdent.2012.10.001 j o u r n a l o f d e n t i s t r y 4 1 s ( 2 0 1 3 ) s 2 6 – s 3 3 S27 40–42 The term dentin hypersensitivity is almost always de- containing potassium ion. This technology has also been scribed as a short episode of sharp pain that arises from shown to provide instant relief after a single direct topical 43–45 exposed dentin, typically in response to chemical, thermal, application of the dentifrice. 9 tactile and osmotic stimulation. Up to 57% of patients have There are a variety of dental products known to success- 10–13 been reported to be affected by this condition. Most fully address dentine hypersensitivity. A new mouthwash TM hypersensitive teeth are accompanied by gingival recession, using the Pro-Argin Mouthwash Technology was designed the result of periodontal disease, periodontal therapy or to effectively reduce dentin hypersensitivity. The mouthwash 14,15 46,47 improper brushing. In a healthy tooth, the dental pulp is efficacy is based on occlusion of the dentin tubules, covered by dentin which is protected by enamel above the provided by a proprietary formulation of arginine, PVM/MA gingiva and cementum and the gingiva themselves below the copolymer and pyrophosphates. 16 gingiva. Just as the enamel covers and protects the Therefore, the aim of this eight week, single-center, two-cell, underlying dentin from external stimuli, the gingiva protects double-blind, and randomized clinical study conducted in the the underlying cementum and root dentin. When the gingiva Chengdu, China area, was to evaluate the dentin hypersensi- recedes, the protective cementum can be easily removed so tivity reduction efficacy of two mouthwashes, one containing that the dentin tubules are exposed and open, thereby 0.8% arginine, PVM/MA copolymer, pyrophosphates, and 0.05% transmitting the pain producing stimuli. sodium fluoride (‘‘Arginine Mouthwash’’) and the other con- The hydrodynamic theory of dentin hypersensitivity taining 0.05% sodium fluoride (‘‘Negative Control’’). proposed by Brannstrom in 1963 remains the widely accepted 17,18 theory of how dentin hypersensitivity occurs. It attributes 2. Materials and methods fluid movement within exposed dentin tubules to the transmission of painful sensation. Specifically, non-noxious stimuli at the tooth surface can trigger fluid movement within This clinical study employed a randomized assignment, the dentin tubules affecting the pulpal mechanoreceptors and double-blind, two-treatment, parallel-group design. Adult resulting in the sensation of pain. Under a microscope, a subjects from the Chengdu, China area were enrolled in the sensitive tooth shows widened dentin tubules, as much as two study. times larger than tubules of normal dentin, and in greater number per area compared to a tooth without dentin 2.1. Sample size determination 19 hypersensitivity. Treatment and prevention of dentin hypersensitivity focuses on eliminating the ability of external The sample size of 90 (45 per group) was determined based on stimuli to trigger pain. Currently one of two approaches is a standard deviation (SD), for the response measure tactile typically used. The first is to block the triggers of nerve activity sensitivity (or air blast) of 3.34 (or 0.31), a significance level of by treating the tooth with a physical or chemical agent that a = 0.05, a 10% attrition rate and an 80% level of power. The forms a layer which mechanically occludes the dentin tubules study was powered to detect a minimal statistically significant and prevents pulpal fluid flow. The second is by interrupting difference between the study means of 20%. The sample size the neural response to pain stimuli by delivering potassium calculation utilized a historical data from previous studies. salts to the tubule area where they have a depolarizing effect on electrical nerve conduction, causing nerve fibers to be less 2.2. Inclusion criteria excitable to the stimuli, thereby reducing a patient’s sensation of pain. The occluding agent or potassium salt is generally delivered by incorporating it into an oral health product so that (i) had to be between the ages of 18 and 70 (inclusive) and in patients can treat the condition at home during normal oral general good health, 20–23 hygiene procedures. (ii) required to possess a minimum of two hypersensitive The most common products used by patients seeking pain teeth which were anterior to the molars and demonstrat- relief from dentin hypersensitivity are desensitizing denti- ed cervical erosion/abrasion or gingival recession; and for frices. In the past, these dentifrices usually contained which a tactile sensitivity stimuli score of 10–50 g of force potassium salts – potassium nitrate, potassium citrate, (Yeaple Probe) and an air blast stimuli score of 2 or 3 (Schiff potassium chloride – which are believed to have a depolarizing Cold Air Sensitivity Scale) were presented at the baseline effect on electrical nerve conduction, causing nerve fibers to examination, 24–39 be less excitable to the stimuli. Recently, a new dentifrice (iii) required to be available for the eight week duration of the product was introduced which has been clinically proven to study and to sign an informed consent form. provide superior dentin hypersensitivity relief. The dentifrice contains 8% arginine, calcium carbonate and 1450 ppm Subjects were excluded from the study if they: fluoride as sodium monofluorophosphate. Arginine, an amino acid, historically has been studied for its potential oral health (i) had gross oral pathology, chronic disease, advanced benefits. It was shown that a combination of arginine and periodontal disease, had undergone treatment for peri- calcium carbonate when deposited on exposed dentin odontal disease (within the last 12 months), or if they had surfaces is able to physically block and seal open dentin hypersensitive teeth with a mobility greater than one, tubules. The novel dentifrice has been reported in numerous (ii) had teeth with extensive/defective restorations (including clinical studies to provide superior relief of dentin hypersen- prosthetic crowns), suspected pulpitis, caries, cracked sitivity when compared to a leading sensitivity dentifrice enamel or that were used as abutments for removable S28 j o u r n a l o f d e n t i s t r y 4 1 s ( 2 0 1 3 ) s 2 6 – s 3 3 partial dentures. Began taking anticonvulsants, antihis- baseline-designated study teeth, were conducted after tamines, antidepressants, sedatives, tranquilizers, anti- two, four and eight weeks of product use.
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