DOCSLIB.ORG

Phosphorus Oxychloride Hazard Summary

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Phosphorus Oxychloride Hazard Summary Common Name: PHOSPHORUS OXYCHLORIDE CAS Number: 10025-87-3 RTK Substance number: 1523 DOT Number: UN 1810 (PIH) Date: May 1989 Revised: September 2001 ------------------------------------------------------------------------- ------------------------------------------------------------------------- HAZARD SUMMARY * Phosphorus Oxychloride can affect you when breathed in training concerning chemical hazards and controls. The and by passing through your skin. federal OSHA Hazard Communication Standard, 1910.1200, * Phosphorus Oxychloride is a CORROSIVE CHEMICAL requires private employers to provide similar training and and contact can severely irritate and burn the skin and eyes information to their employees. with possible eye damage. * Breathing Phosphorus Oxychloride can irritate the nose * Exposure to hazardous substances should be routinely and throat. evaluated. This may include collecting personal and area * Breathing Phosphorus Oxychloride can irritate the lungs air samples. You can obtain copies of sampling results causing coughing and/or shortness of breath. Higher from your employer. You have a legal right to this exposures can cause a build-up of fluid in the lungs information under OSHA 1910.1020. (pulmonary edema), a medical emergency, with severe * If you think you are experiencing any work-related health shortness of breath. problems, see a doctor trained to recognize occupational * High exposure to Phosphorus Oxychloride can cause diseases. Take this Fact Sheet with you. nausea, vomiting, headache, dizziness, weakness and loss of appetite. WORKPLACE EXPOSURE LIMITS * Phosphorus Oxychloride may cause kidney damage. NIOSH: The recommended airborne exposure limit is * Phosphorus Oxychloride is a REACTIVE CHEMICAL 0.1 ppm averaged over a 10-hour workshift and and an EXPLOSION HAZARD. 0.5 ppm, not to be exceeded during any 15 * Phosphorus Oxychloride is a DOT Poison Inhalation minute work period. Hazard (PIH). ACGIH: The recommended airborne exposure limit is IDENTIFICATION 0.1 ppm averaged over an 8-hour workshift. Phosphorus Oxychloride is a colorless to pale yellow, fuming, oily liquid with a strong odor. It is used as a * The above exposure limits are for air levels only. When chlorinating agent, and in making semiconductors, gasoline skin contact also occurs, you may be overexposed, even additives, plasticizers, hydraulic fluids, and organophosphorus though air levels are less than the limits listed above. compounds such as pesticides. WAYS OF REDUCING EXPOSURE REASON FOR CITATION * Where possible, enclose operations and use local exhaust * Phosphorus Oxychloride is on the Hazardous Substance ventilation at the site of chemical release. If local exhaust List because it is cited by ACGIH, DOT, NIOSH, DEP, ventilation or enclosure is not used, respirators should be NFPA and EPA. worn. * This chemical is on the Special Health Hazard Substance * Wear protective work clothing. List because it is CORROSIVE and REACTIVE. * Wash thoroughly immediately after exposure to * Definitions are provided on page 5. Phosphorus Oxychloride and at the end of the workshift. * Post hazard and warning information in the work area. In HOW TO DETERMINE IF YOU ARE BEING addition, as part of an ongoing education and training EXPOSED effort, communicate all information on the health and The New Jersey Right to Know Act requires most employers safety hazards of Phosphorus Oxychloride to potentially to label chemicals in the workplace and requires public exposed workers. employers to provide their employees with information and PHOSPHORUS OXYCHLORIDE page 2 of 6 This Fact Sheet is a summary source of information of all If symptoms develop or overexposure is suspected, the potential and most severe health hazards that may result from following is recommended: exposure. Duration of exposure, concentration of the substance and other factors will affect your susceptibility to any of the * Consider chest x-ray after acute overexposure. potential effects described below. --------------------------------------------------------------------------- Any evaluation should include a careful history of past and present symptoms with an exam. Medical tests that look for HEALTH HAZARD INFORMATION damage already done are not a substitute for controlling exposure. Acute Health Effects The following acute (short-term) health effects may occur Request copies of your medical testing. You have a legal right immediately or shortly after exposure to Phosphorus to this information under OSHA 1910.1020. Oxychloride: Mixed Exposures * Contact can severely irritate and burn the skin and eyes * Because smoking can cause heart disease, as well as lung with possible eye damage. cancer, emphysema, and other respiratory problems, it may * Breathing Phosphorus Oxychloride can irritate the nose worsen respiratory conditions caused by chemical exposure. and throat. Even if you have smoked for a long time, stopping now will * Breathing Phosphorus Oxychloride can irritate the lungs reduce your risk of developing health problems. causing coughing and/or shortness of breath. Higher exposures can cause a build-up of fluid in the lungs WORKPLACE CONTROLS AND PRACTICES (pulmonary edema), a medical emergency, with severe shortness of breath. Unless a less toxic chemical can be substituted for a hazardous * High exposure to Phosphorus Oxychloride can cause substance, ENGINEERING CONTROLS are the most nausea, vomiting, headache, dizziness, weakness and loss effective way of reducing exposure. The best protection is to of appetite. enclose operations and/or provide local exhaust ventilation at the site of chemical release. Isolating operations can also Chronic Health Effects reduce exposure. Using respirators or protective equipment is The following chronic (long-term) health effects can occur at less effective than the controls mentioned above, but is some time after exposure to Phosphorus Oxychloride and can sometimes necessary. last for months or years: In evaluating the controls present in your workplace, consider: Cancer Hazard (1) how hazardous the substance is, (2) how much of the * According to the information presently available to the New substance is released into the workplace and (3) whether Jersey Department of Health and Senior Services, harmful skin or eye contact could occur. Special controls Phosphorus Oxychloride has not been tested for its ability should be in place for highly toxic chemicals or when to cause cancer in animals. significant skin, eye, or breathing exposures are possible. Reproductive Hazard In addition, the following controls are recommended: * According to the information presently available to the New Jersey Department of Health and Senior Services, * Where possible, automatically pump liquid Phosphorus Phosphorus Oxychloride has not been tested for its ability Oxychloride from drums or other storage containers to to affect reproduction. process containers. * Before entering a confined space where Phosphorus Other Long-Term Effects Oxychloride may be present, check to make sure that an * Phosphorus Oxychloride may cause kidney damage. explosive concentration does not exist. Good WORK PRACTICES can help to reduce hazardous MEDICAL exposures. The following work practices are recommended: Medical Testing * Workers whose clothing has been contaminated by For those with frequent or potentially high exposure (half the Phosphorus Oxychloride should change into clean TLV or greater), the following are recommended before clothing promptly. beginning work and at regular times after that: * Contaminated work clothes should be laundered by individuals who have been informed of the hazards of * Lung function tests. exposure to Phosphorus Oxychloride. * Kidney function tests. PHOSPHORUS OXYCHLORIDE page 3 of 6 * Eye wash fountains should be provided in the immediate * Where the potential exists for exposure over 0.1 ppm, use a work area for emergency use. MSHA/NIOSH approved supplied-air respirator with a full * If there is the possibility of skin exposure, emergency facepiece operated in a pressure-demand or other positive- shower facilities should be provided. pressure mode. For increased protection use in combination * On skin contact with Phosphorus Oxychloride, with an auxiliary self-contained breathing apparatus immediately wash or shower to remove the chemical. At operated in a pressure-demand or other positive-pressure the end of the workshift, wash any areas of the body that mode. may have contacted Phosphorus Oxychloride, whether or not known skin contact has occurred. HANDLING AND STORAGE * Do not eat, smoke, or drink where Phosphorus Oxychloride is handled, processed, or stored, since the * Prior to working with Phosphorus Oxychloride you chemical can be swallowed. Wash hands carefully before should be trained on its proper handling and storage. eating, drinking, smoking, or using the toilet. * Phosphorus Oxychloride will react violently with WATER, MOISTURE or STEAM to form Hydrogen PERSONAL PROTECTIVE EQUIPMENT Chloride and Phosphoric Acid. * Phosphorus Oxychloride is not compatible with WORKPLACE CONTROLS ARE BETTER THAN CARBON DISULFIDE; DIMETHYL FORMAMIDE; PERSONAL PROTECTIVE EQUIPMENT. However, for METALS; ALCOHOLS; STRONG BASES (such as some jobs (such as outside work, confined space entry, jobs SODIUM HYDROXIDE and POTASSIUM done only once in a while, or jobs done while workplace HYDROXIDE); and STRONG ACIDS (such as controls are being installed), personal protective equipment HYDROCHLORIC, SULFURIC and NITRIC). may be appropriate. * Store
Load more

Recommended publications
  • Preparation of Aromatic Carbonyl Compounds
    ~" ' MM II II II Ml I III II II I Ml II I II J European Patent Office © Publication number: 0 178 184 B1 Office_„. europeen- desj brevets^ » © EUROPEAN PATENT SPECIFICATION © Date of publication of patent specification: 28.04.93 © Int. CI.5: C07C 45/45, C07C 49/76, C07C 51/58 © Application number: 85307320.3 @ Date of filing: 11.10.85 © Preparation of aromatic carbonyl compounds. © Priority: 11.10.84 US 659598 (73) Proprietor: RAYCHEM CORPORATION (a Dela- ware corporation) @ Date of publication of application: 300 Constitution Drive 16.04.86 Bulletin 86/16 Menlo Park, California 94025(US) © Publication of the grant of the patent: @ Inventor: Horner, Patrick James 28.04.93 Bulletin 93/17 139 Buckthorn Way Menlo Park California 94025(US) © Designated Contracting States: Inventor: Jansons, Vlktors AT BE CH DE FR GB IT LI NL SE 123 New York Avenue Los Gatos California 95030(US) References cited: Inventor: Gors, Helnrlch Carl EP-A- 0 024 286 EP-A- 0 069 598 2508 Mardell Way DE-A- 2 014 514 GB-A- 1 420 506 Mountain View California, 94043(US) GB-A- 2 103 604 US-A- 1 874 580 US-A- 3 282 989 Representative: Jay, Anthony William et al Raychem Limited Intellectual Property Law Department Faraday Road Dorcan Swindon Wiltshire (GB) 00 00 00 Note: Within nine months from the publication of the mention of the grant of the European patent, any person ® may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition CL shall be filed in a written reasoned statement.
    [Show full text]
  • 5 Phosphorus Oxychloride1 Acute Exposure Guideline Levels
    Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 10 Committee on Acute Exposure Guideline Levels Committee on Toxicology Board on Environmental Studies and Toxicology Division on Earth and Life Studies Copyright © National Academy of Sciences. All rights reserved. Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 10 THE NATIONAL ACADEMIES PRESS 500 FIFTH STREET, NW WASHINGTON, DC 20001 NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Insti- tute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance. This project was supported by Contract No. W81K04-06-D-0023 and EP-W-09-007 be- tween the National Academy of Sciences and the U.S. Department of Defense and the U.S. Environmental Protection Agency. Any opinions, findings, conclusions, or recom- mendations expressed in this publication are those of the author(s) and do not necessarily reflect the view of the organizations or agencies that provided support for this project. International Standard Book Number-13: 978-0-309-21987-7 International Standard Book Number-10: 0-309-21987-6 Additional copies of this report are available from The National Academies Press 500 Fifth Street, NW Box 285 Washington, DC 20055 800-624-6242 202-334-3313 (in the Washington metropolitan area) http://www.nap.edu Copyright 2011 by the National Academy of Sciences.
    [Show full text]
  • Psilocybin † † † ‡ Haden A
    Review pubs.acs.org/chemneuro DARK Classics in Chemical Neuroscience: Psilocybin † † † ‡ Haden A. Geiger, Madeline G. Wurst, and R. Nathan Daniels*, , † Department of Pharmaceutical Sciences, Lipscomb University College of Pharmacy and Health Sciences, Nashville, Tennessee 37204, United States ‡ Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232-6600, United States ABSTRACT: Psilocybin is found in a family of mushrooms commonly known as “magic mushrooms” that have been used throughout history to induce hallucinations. In the late 1950s Albert Hofmann, of Sandoz Laboratories, identified and synthesized the psychoactive compounds psilocybin and psilocin which are found in psilocybe mushrooms. Psilocybin was marketed by Sandoz as Indocybin for basic psychopharmacological and therapeutic clinical research. Psilocybin saw a rapid rise in popularity during the 1960s and was classed as a Schedule I drug in 1970. This led to a significant decrease in psilocybin research. Recently, however, preliminary studies with psilocybin have shown promise as potential for the treatment of obsessive compulsive disorder, alcohol addiction, tobacco addiction, and major depressive disorder, and the treatment of depression in terminally ill cancer patients. This review describes in detail the synthesis, metabolism, pharmacology, adverse drug reactions, and importance of psilocybin to neuroscience in the past and present. KEYWORDS: Psilocybin, psilocin, indolealkylamine, hallucinogen, psychedelic, magic mushrooms, mushrooms, O-acetylpsilocin, indocybin I. INTRODUCTION The structure of psilocybin, and other indolealkylamine Psilocybin (1, Figure 1), a tryptamine alkaloid, is found in a hallucinogens, is similar to that of the endogenous neuro- family of mushroom-forming fungi that when ingested can transmitter serotonin (3), the hormone melatonin (4), and the hypothesized endogenous psychedelic, N,N-dimethyltrypt- cause hallucinations.
    [Show full text]
  • Solvent-Free and Safe Process for the Quantitative Production of Phosgene from Triphosgene by Deactivated Imino-Based Catalysts
    Organic Process Research & Development 2010, 14, 1501–1505 Solvent-Free and Safe Process for the Quantitative Production of Phosgene from Triphosgene by Deactivated Imino-Based Catalysts Heiner Eckert* and Johann Auerweck Department of Chemistry, Technische UniVersitaet Muenchen, Lichtenbergstr. 4, Garching 85747, Germany Abstract: Scheme 1. Decomposition of triphosgene (1a) into carbon tetrachloride, carbon dioxide, and 1 equiv of phosgene (3) Phosgene is quantitatively formed from solid triphosgene in a solvent-free and safe process without any reaction heat, catalyzed by planar N-heterocycles with deactivated imino functions. The rate of phosgene generation is adjustable to the rate of phosgene consumption in the subsequent phosgenation reaction by thermal control, catalyst concentration, and in some cases, specific proper- ties of selected metal phthalocyanines. A thermal runaway reaction of this process is impossible. phosgene in most reactions, yet several phosgenation reactions are advantageously carried out with phosgene, that is, when excessive triphosgene is difficult to remove during the reaction Introduction workup because of its high boiling point of over 200 °C. Its Phosgene (3) is a highly useful and versatile chemical in excess can be destroyed by hydrolysis, when phosgenation performing syntheses.1a Although consisting of only four atoms, products are not sensitive to moisture as are carbonates, four important transformations can be carried out with it in carbamates, ureas, diarylketones, alkylhalides, cyanides, and organic
    [Show full text]
  • United States Patent (19) 11 Patent Number: 5,677,453 Cramm Et Al
    US005677453A United States Patent (19) 11 Patent Number: 5,677,453 Cramm et al. 45 Date of Patent: Oct. 14, 1997 54 PROCESS FOR THE PREPARATION OF 46 R. Hull, A New Sythesis of 4:6-dihydroxypyrimidines-J. DCHLOROPYRIMDINES Chem. Soc. (1951) p. 2214. Contribution a la synthese de la dichloro-4-6 pyrimidine, 75 Inventors: Ginther Cramm; Wolker Kiss, both Hennart et al., Bull. de la Soc. Chim. France, (1959) pp. of Leverkusen; Guido Stefan, 741-742. Odenthal, all of Germany Experiments on the Synthesis of Purine Nucleosides. Part IV. Kenner et al., J. Chem. Soc. (1943), pp. 574-575. 73) Assignee: Bayer Aktiengesellschaft, Leverkusen, A New Synthesis of 4:6-Dihydroxpyrimidines, Hull, J. Germany Chem. Soc. (1951), p. 2214. Synthesis of 21 Appl. No.: 699,812 4-(p-Aminobenzenesulfonamido)-6-Methoxypyrimidine, 22 Filed: Aug. 19, 1996 Zasosov et al., Translated from Khimiko-Farmatsevticheskii Zhurnal, vol. 8, No. 12, pp. 28–31, Dec., 1974. Original 30 Foreign Application Priority Data article submitted Dec. 6, 1973. Aug. 25, 1995 DEl Germany ........................ 19531 299.6 Primary Examiner-John M. Ford Attorney, Agent, or Firm-Sprung Horn Kramer & Woods (51) Int. Cl. ... C07D 239/30 52 U.S. Cl. ..................... ... 544/334 57 ABSTRACT 58) Field of Search ............................................. 544/334 4,6-Dichloropyrimidines are obtained by the reaction of (56) References Cited 4,6-dihydroxypyrimidines with excess phosphoryl chloride in a particularly advantageous manner when no base is FOREIGN PATENT DOCUMENTS added, during and/or after the reaction 0.75 to 1.5 mol of O 251 246A1 1A1988 European Pat. Off.. phosphorus trichloride and 0.7 to 1.3 mol of chlorine are O 697 406A1 2/1996 European Pat.
    [Show full text]
  • Phosphonate–Phosphonochloridate Conversion Bogdan Iorga, Duncan Carmichael, Philippe Savignac
    Phosphonate–phosphonochloridate conversion Bogdan Iorga, Duncan Carmichael, Philippe Savignac To cite this version: Bogdan Iorga, Duncan Carmichael, Philippe Savignac. Phosphonate–phosphonochloridate conversion. Comptes rendus de l’Académie des sciences. Série IIc, Chimie, Elsevier, 2000, 3 (11-12), pp.821-829. 10.1016/s1387-1609(00)01207-x. hal-03161486 HAL Id: hal-03161486 https://hal.archives-ouvertes.fr/hal-03161486 Submitted on 10 Mar 2021 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Phosphonate-Phosphonochloridate Conversion Bogdan Iorga, Duncan Carmichael, Philippe Savignac Laboratoire Hétéroéléments et Coordination, UMR CNRS 7653, DCPH, Ecole Polytechnique, 91128 Palaiseau Cedex, France; E-mail : [email protected] __________________________________________________________________________________________ Abstract - This review deals with the phosphonate-phosphonochloridate conversion. The different phosphorus-chlorine bond forming reagents (COCl2, (COCl)2, SOCl2, PCl5, POCl3, Ph3PCl2, trichloro(o-phenylenedioxy)phosphorane)
    [Show full text]
  • Searching for New Biologically Active Compounds Derived from Isoquinoline Alkaloids †
    Proceeding Paper Searching for New Biologically Active Compounds Derived from Isoquinoline Alkaloids † Anna Kmieciak 1, Marta Ćwiklińska 1, Karolina Jeżak 1, Afef Shili 2 and Marek P. Krzemiński 1,* 1 Faculty of Chemistry, Nicolaus Copernicus University, 87-100 Toruń, Poland; [email protected] (A.K.); [email protected] (M.Ć.); [email protected] (K.J.) 2 Chemistry Department, Faculty of Sciences of Sfax, University of Sfax, Sfax 3029, Tunisia; [email protected] * Correspondence: [email protected] † Presented at the 24th International Electronic Conference on Synthetic Organic Chemistry, 15 November–15 December 2020; Available online: https://ecsoc-24.sciforum.net/. Abstract: Many isoquinoline alkaloids are biologically active compounds and successfully used as pharmaceuticals. Compounds belonging to the isoquinolines and tetrahydroisoquinolines (TIQs) can be used as anesthetics, antihypertensive drugs, antiviral agents, and vasodilators. In the presented studies, the search for new compounds and synthesis of tetrahydroisoquinoline alkaloid derivatives was undertaken. Several dihydroisoquinolines were synthesized by Bishler–Napieralski reaction from the corresponding amides. Dihydroisoquinolines were reduced with sodium borohydride to obtain racemic tetrahydroisoquinolines. Asymmetric reduction of selected 3,4-dihydroisoquinolines was attempted with borane in the presence of chiral terpene spiroboranes. Keywords: isoquinoline; alkaloids; biologically active compound Citation: Kmieciak, A.; Ćwiklińska, M.; Jeżak, K.; Shili, A.; Krzemiński, M.P. Searching for New Biologically 1. Introduction Active Compounds Derived from Isoquinoline Alkaloids. Chem. Proc. Isoquinoline and its derivatives are used as starting materials in the synthesis of 2021, 3, 97. https://doi.org/10.3390/ dyes, insecticides, and pharmaceuticals. Tetrahydroisoquinoline (TIQ) is one of many ecsoc-24-08417 representatives of N-heterocyclic compounds.
    [Show full text]
  • Searching for New Biologically Active Compounds Derived from Isoquinoline Alkaloids †
    Proceedings Searching for New Biologically Active Compounds Derived from Isoquinoline Alkaloids † Anna Kmieciak 1, Marta Ćwiklińska 1, Karolina Jeżak 1, Afef Shili 2 and Marek P. Krzemiński 1 1 Faculty of Chemistry, Nicolaus Copernicus University, Toruń, Poland 2 Chemistry Department, Faculty of Sciences of Sfax, University of Sfax, Tunisia † Presented at the 24th International Electronic Conference on Synthetic Organic Chemistry, 15 November– 15 December 2020; Available online: https://ecsoc-24.sciforum.net/. Received: date; Accepted: date; Published: date Abstract: Many isoquinoline alkaloids are biologically active compounds and are successfully used as pharmaceuticals. Compounds belonging to isoquinolines and tetrahydroisoquinolines (TIQs) can be used as anesthetics, antihypertensive drugs, antiviral agents, and vasodilators. In the presented studies, the search for new compounds and synthesis of tetrahydroisoquinoline alkaloid derivatives was undertaken. Several dihydroisoquinolines were synthesized by Bishler-Napieralski reaction from the corresponding amides. Dihydroisoquinolines were reduced with sodium borohydride to obtain racemic tetrahydroisoquinolines. Asymmetric reduction of selected 3,4-dihydroisoquinolines was attempted with borane in the presence of chiral terpene spiroboranes. Keywords: isoquinoline; alkaloids; biologically active compound 1. Introduction Isoquinoline and its derivatives are used as starting materials in the synthesis of dyes, insecticides, and pharmaceuticals. Tetrahydroisoquinoline (TIQ) is one of
    [Show full text]
  • Phosphoryl Trichloride Cas N°: 10025-87-3
    OECD SIDS PHOSPHORYL TRICHLORIDE FOREWORD INTRODUCTION PHOSPHORYL TRICHLORIDE CAS N°: 10025-87-3 UNEP PUBLICATIONS 1 OECD SIDS PHOSPHORYL TRICHLORIDE SIDS Initial Assessment Report For SIAM 19 Berlin, Germany, 19-22 October 2004) 1. Chemical Name: Phosphoryl trichloride 2. CAS Number: 10025-87-3 3. Sponsor Country: Germany Contact Point: BMU (Bundesministerium für Umwelt, Naturschutz und Reaktorsicherheit) Contact person: Prof. Dr. Ulrich Schlottmann Postfach 12 06 29 D- 53048 Bonn 4. Shared Partnership with: 5. Roles/Responsibilities of the Partners: Name of industry sponsor Bayer AG, Germany /consortium Contact person: Dr. Burkhardt Stock D-51368 Leverkusen Gebäude 9115 Process used The BUA Peer Review Process : see next page 6. Sponsorship History How was the chemical or by ICCA-Initiative category brought into the OECD HPV Chemicals Programme ? 7. Review Process Prior to last literature search (update): the SIAM: 14 March 2004 (Human Health): databases medline, toxline; search profile CAS-No. and special search terms 9 March 2004 (Ecotoxicology): databases CA, biosis; search profile CAS-No. and special search termsOECD/ICCA 8. Quality check process: As basis for the SIDS-Dossier the IUCLID was used. All data have been checked and validated by BUA. A final evaluation of the human health part has been performed by the Federal Institute for Risk Assessment (BfR) and of the ecotoxicological part by the Federal Environment Agency (UBA). 2 UNEP PUBLICATIONS OECD SIDS PHOSPHORYL TRICHLORIDE 9. Date of Submission: Deadline for circulation: 23 July 2004 10. Date of last Update: Last literature search: IUCLID Chapters 1-4: Chapter 5: 2003-05-01 11. Comments: OECD/ICCA - The BUA* Peer Review Process Qualified BUA personnel (toxicologists, ecotoxicologists) perform a quality control on the full SIDS dossier submitted by industry.
    [Show full text]
  • Template for Writing Articles for Thieme Chemistry Journals
    1 SYNLETT: LETTER Organocatalytic phosphorylation of alcohols using pyridine-N-oxide James I. Murray,a Rudiger Woscholskia,b and Alan C. Spiveya* aDepartment of Chemistry, South Kensington Campus, Imperial College London, SW7 2AZ, United Kingdom bInstitute of Chemical Biology, Imperial College London, London SW7 2AZ, United Kingdom Fax: +44 (0)20 759 45841 E-mail: [email protected] Received: The date will be inserted once the manuscript is accepted. Abstract: Phosphorylation of alcohols by phosphoryl chlorides catalyzed by pyridine-N-oxide is reported. The utility of this method is demonstrated through phosphorylation of primary, secondary and a tertiary alcohol as well as phenols under mild reaction conditions and with low catalyst loading (5 mol%). Key words: Phosphorylation, alcohols, pyridine-N-oxide, organocatalysis. O Exisiting methods O O O Phosphorylation of alcohol groups in e.g. peptides, Exisiting methods O Lewis acids: P P Cl OR O N OR Cl proteins, inositols, glycerols and steroids plays a t OR OR 1) Ti(O Bu)4 (5-20 mol%) + A or C 4 or Ph or A Ph B pivotal role in many physiologically important 2) TiCl mol%) + A 2) TiCl4 (2(2 mol%) + O Jones et al. (refs 9-13; R = Ph, Et) 1 or processes. Disease states including cancers and 1 3) Cu(OTf) 2 (20 mol%) + B 1 P OR R OH 2 R1O O O OR 1 ° ° ° Et N or i-Pr NEt P P OBn immune system disorders are often characterized by R = 1°,2°,3° Et3N or i-Pr2NEt R = Ph, Bn, Et BnO O OBn C CH Cl BnO 2,3 & phenolic CH2Cl2 BnO OBn perturbation of these processes.
    [Show full text]
  • United States Patent Office Faterated (Oct
    3,153,081 United States Patent Office Faterated (Oct. 13, 1964 2 3,153,081 Substitution-i.e., monophosphorylation-has been ac PROCESS FOR PREPARNG PHENYL complished to a very great extent as will be seen from PHOSPHORODCHLOREDATES the ensuing description. - Francis X. Markley, Botand Brook, N.J., and Calvin . Another feature of this invention is that the catalysts Worrel, Detroit, Mich., assignors to Ethyl Corporation, are highly specific. For example, whereas m-cresol and New York, N.Y., a corporation of Virginia phosphoryl chloride must be heated above 200° C. for 5 No Drawing. Filed Oct. 26, 1962, Ser. No. 233,435 to 6 hours to obtain m-tolyl phosphorodichloridate, the 7 Claims. (Ci. 260-461) presence in the same reaction mixture of as little as one This invention relates to, and has as its principal object, mole percent of aluminum chloride, based on the phenol, the preparation of phenyl phosphorodichloridates. O made it possible to complete the reaction in 40 to 50 min This application is a continuation-in-part of S.N. utes at 105 C. In sharp contrast to this, magnesium and 730,265, filed April 23, 1958, now abandoned. zinc dust, magnesium and zinc chlorides, phosphorus tri Phenyl phosphorodichloridates are very useful chemi chloride and the highly-acidic protonated acids-trichloro cal intermediates in the synthesis of phenyl dimethyl phos acetic and p-toluene sulfonic acids-have been investi phates. Many of the latter compounds are exceptionally 15 gated as possible catalysts in this reaction. Of these, effective ignition control compounds when blended in only magnesium chloride and phosphorus trichloride gave small quantity with leaded gasoline.
    [Show full text]
  • United Nations
    UN/SCETDG/46/INF.33 UN/SCEGHS/28/INF.18 Committee of Experts on the Transport of Dangerous Goods and on the Globally Harmonized System of Classification and Labelling of Chemicals 24 November 2014 Sub-Committee of Experts on the Sub-Committee of Experts on the Globally Harmonized Transport of Dangerous Goods System of Classification and Labelling of Chemicals Forty-sixth session Twenty-eight session Geneva, 1– 9 December 2014 Geneva, 10 – 12 (morning) December 2014 Item 8 (c) of the provisional agenda Item 2 (b) (i) of the provisional agenda Classification criteria and related hazard Issues relating to the Globally Harmonized System communication: work of the Sub-Committee of Experts of Classification and Labelling of Chemicals: on the Transport of Dangerous Goods (TDG): physical criteria for water reactivity hazards Criteria for water-reactivity, agenda item 8(c) HM-14 project status report Transmitted by the expert from the United States of America Introduction 1. During previous sessions, the Sub-Committee has been presented with information related to the development of criteria and test methods for the classification of materials that in contact with water evolve toxic and/or flammable gases (see INF.40 of the 42nd session and ST/SG/AC.10/C.3/2013/21) through a contract managed by the U.S. Transportation Research Board (TRB). This work is now complete and the full report titled: HM-14: Test Procedures and Classification Criteria for Release of Toxic Gases from Water-Reactive Materials published on 8 October, 2014. The report is available online: http://onlinepubs.trb.org/onlinepubs/hmcrp/hmcrp_rpt_013.pdf 2.
    [Show full text]