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ABSTRACT BOOK Sustainability Committee ABSTRACT BOOK Sustainability Committee Prof. Ahmet ÇOLAK, Karadeniz Technical University Prof. Hasan ÖZDEMİR, Atatürk University Prof. Ali KILINÇ, Ege University Prof. Emel EMREGÜL, Ankara University Assoc. Prof. Ali ALKAN, Karadeniz Technical University, Chairman of Chemists Society Karad. Branch Chairman Prof. Emel EMREGÜL, Ankara University Vice Chairmen Prof. Ahmet ÇABUK, Eskişehir Osmangazi University (Vice Rector) Prof. İsmet YILMAZ, Malatya Turgut Özal University (Vice Rector) Congress Secretary Assoc. Prof. Pınar Acar BOZKURT, Ankara University Congress Coordinator Chem. İkram CENGİZ, Chairman of Chemists Society Advisory Board Prof. Emel ARINÇ, Middle East Technical University (Retired) Prof. Ural AKBULUT, Middle East Technical University (Retired) Prof. Ö. İrfan KÜFREVİOĞLU, Atatürk University Prof. Şule PEKYARDIMCI, Ankara University (Retired) Prof. Seyhan TÜKEL, Çukurova University (Vice Rector) Prof. Oktay ARSLAN, Balıkesir University 1 Organizing Committee Prof. Orhan ATAKOL, Ankara University Prof. Fatma ARSLAN, Gazi University Prof. Vedat TÜRKOĞLU, Van Yüzüncüyıl University Prof. Ayhan ORAL, Çanakkale Onsekiz Mart University Prof. Azra BOZCAARMUTLU, Bolu İzzet Baysal University Prof. Mehmet DOĞRU, Dicle University Prof. T. Abdulkadir ÇOBAN, Erzincan University Assoc. Prof. Melike YILDIRIM AKATIN, Karadeniz Technical University Assoc. Prof. Harun BUDAK, Atatürk University Assoc. Prof. Nalan ÖZDEMİR, Erciyes University Assoc. Prof. Gülşah ŞANLI MOHAMED, İzmir Institute of Technology Assoc. Prof. Yakup KOLCUOĞLU, Karadeniz Technical University Assoc. Prof. Seyhan ULUSOY, Süleyman Demirel University Assoc. Prof. Nilay BERELİ, Hacettepe University Assoc. Prof. Barış BİNAY, Gebze Technical University Assoc. Prof. Lokman UZUN, Hacettepe University Assoc. Prof. Aytuğ OKUMUŞ, Ankara University Assoc. Prof. Emirhan NEMUTLU, Hacettepe University Assist. Prof. Şebnem EŞSİZ, Kadir Has University Assist. Prof. Barbaros DİNÇER, Recep Tayyip Erdoğan University Dr. Mehtap YAKUT ÖZGÜR, Ankara University Dr. Gökhan GÜNGÖR, Microbiota Murat Can ANARAT, Consultancy Firm 2 Scientific Committee Prof. Jean-François GERARD, National Institute of Applied Sciences of Lyon Prof. Alvaro MATA, Queen Mary University of London Prof. Ahmed JASHARI, University of Tetova Prof. Hatem MAJDOUB, University of Monastir Prof. Alain THIERRY, Institute of Cancer Research of Montpellier Prof. Miral DİZDAROĞLU, NIST Prof. Ayşe OGAN, Marmara University Prof. İlhami GÜLÇİN, Atatürk University Prof. Uğur SEZERMAN, Acıbadem University Prof. Leman TARHAN, Dokuz Eylül University Prof. Şükrü BEYDEMİR, Anadolu University Prof. İsmail KIRAN, Eskişehir Osman Gazi University Prof. Refiye YANARDAĞ, İstanbul University Prof. Hülya YAĞAR, Trakya University Prof. Nagihan SAĞLAM ERTUNGA, Karadeniz Teknik University Prof. Figen ZİHNİOĞLU, Ege University Prof. Barbaros NALBANTOĞLU, Yıldız Teknik University Prof. İsmail ÖZMEN, Süleyman Demirel University Prof. Adil DENİZLİ, Hacettepe University Prof. Özlem YILDIRIM, Ankara University Prof. Handan YAVUZ, Hacettepe University Prof. Nilgün ANCIN, Ankara University Prof. Gül ÖZTAŞ, Ankara University Prof. Turgay SEÇKİN, İnönü Üniveristesi Prof. Aydan YILMAZ, Selçuk University Prof. Burhan ATEŞ, İnönü University Assoc. Prof. Andreas G. TZAKOS, University of Ioannina 3 Assoc. Prof. Fatma EROĞLU, Ankara University Assoc. Prof. Melike KALKAN, Ankara University Assoc. Prof. Gökhan DEMİREL, Gazi University Assoc. Prof. Özlem BİNGÖL ÖZAKPINAR, Marmara University Assoc. Prof. Gözde AYDOĞDU TIĞ, Ankara University Assist. Prof. Georg A. FEICHTINGER, Leeds University Local Organizing Committee Prof. Kaan C. EMREGÜL, Ankara University (Chairman) Prof. Şenay ŞANLIER, Ege University Assoc. Prof. Sedat ODABAŞ, Ankara University (Vice Chair) Assoc. Prof. Serdar KARAKURT, Selçuk University Assist. Prof. Burak DERKUŞ, Eskişehir Osmangazi University Assist. Prof. Çağlar ELBÜKEN, Bilkent University Assist. Prof. Yavuz Emre ARSLAN, Çanakkale Onsekiz Mart University Nurettin Mete KALELİ Mesutcan ŞAHİN Hüseyin KORKMAZ Sercan CANTÜRK Mehmet Sait YILMAZ Can Berk CAMCI İsmail KUTLU Sıla BİLGİN Ece KARAKAYA Dilara KURT Açelya ÖZBOŞNAK Melis IŞIK 4 Supramolecular Engineering Of Functional Biomaterials For Advanced Tissue Engineering Alvaro MATA There is great interest to develop new materials with properties that resemble those of biological systems such as hierarchical organization, the capacity to grow or self-heal, and the ability to guide complex biological processes. To this end, supramolecular chemistry offers an exciting opportunity to grow such materials from the bottom-up using molecules and processes found in nature. However, the ability to transform molecular and nano-scale design into functional devices with practical utility at the macroscale remains a challenge. The talk will describe new strategies that integrate supramolecular chemistry with engineering principles to develop practical materials capable of acquiring hierarchical organization, being bioactive, growing, and exhibiting tuneable mechanical properties. These materials are being used towards new regenerative therapies of tissues such as enamel, bone, and blood vessels as well as more biologically relevant in vitro models for applications such as cancer and neurological disorders. 5 POLYMER FIBERS-BASED ELECTROSPUN SCAFFOLDS FOR NEURAL TISSUE ENGINEERING Jean-François GERARD* Co-authors: L. CHAVEZ LINS*, A. HIDALGO IDALBA ANDREINA*, F. WIANNY**, C. DEHAY**, J. DUCHET* (*) Ingénierie des Matériaux Polymères - UMR 5223 CNRS Université de Lyon - INSA Lyon / F69621- Villeurbanne (France) (**) Stem Cell & Brain Research Institute - U1208 INSERM Université de Lyon - Université Lyon 1 / F69500 – Bron (France) Electrospinning process is one of the most promising routes for the design and development of smart textiles based on polymer nanofibers. From a proper selection of the electrospining process parameters and polymers, (multi)functional textiles could be proposed. In this lecture, we will show how biobased polymers, such as PLA-based, and biodegradable polymers, such as PBAT, can be used to prepare electrospun scaffolds. In the first part, electrospinning is applied to neat polylactic acid (PLA) and to PLA-based blends, i.e. PLA/polyethylene glycol-b-polylactic acid block copolymers and PLA/PEG homopolymer. Electrospun membranes exhibit fibers having diameters from 110 to 310 nm depending on the composition and large amounts of porosity (about 80% vol.) which are required for cell culture application. In vitro degradation, as well as the hydrophilicity of the electrospun scaffolds, can be finely tuned from material composition. Fluorescence microscopy shows that the PLA electrospun fibers based scaffolds are good candidates for the survival and proliferation of neural stem cells. Even if the introduction of hydrophilic segments, i.e. polyethylene glycol from PLA-b-PEG block copolymer, leads to the the same level of proliferation than PLA-based membranes, the PLA/PLA-b-PEG electrospun membranes exhibited the suitable hydrolytic degradation required for implantable scaffolds. The second part deals with the development of biodegradable PBAT electrospun membranes with potential applications in the field of smart textiles. As mentioned previously, the fiber morphology is strongly dependent on the tip-collector distance, concentration, and applied voltage. Smooth fibers and beads free membranes could be prepared and analyzed to establish morphology-properties relationships. PBAT membranes having the best thermal and mechanical properties were selected as host of a curli protein which is able to complex heavy metals. In fact, by electrospinning, porous membranes exhibiting a large surface-to-volume ratio could be proposed for chelation of pollutants such as nickel. Related papers: [1] ‘Influence of hydrophilic-hydrophobic bioabsorbable electrospun scaffolds on neural stem cell culture’. L.C. Lins, F. Wianny, S. Livi, C. Dehay, J. Duchet, J.F. Gérard. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 105 (8), 2376-2393 (2017) [2] ‘Development of bioresorbable hydrophilic-hydrophobic electrospun scaffolds for neural tissue engineering’. L.C. Lins, F. Wianny, S. Livi, A. Hidalgo, I. Dalba Andreina, C. Dehay, J. Duchet, J.F. Gérard. Biomacromolecules, 17 (10), 3172–3187 (2016) 6 Discovery of a Cancer Biomarker, Repurposing a Drug and Development of Smart Prodrugs Against Cancer Andreas G. Tzakosa and Serdar KARAKURTb University of Ioannina, Department of Chemistry, Ioannina, GREECE Selcuk University, Faculty of Science, Department of Biochemistry, Konya, TURKEY [email protected] Despite emergence of new systemic therapies, metastatic melanoma remains a challenging and often fatal form of skin cancer. The renin-angiotensin system (RAS) is a major physiological regulatory pathway controlling salt-water equilibrium, intravascular volume and blood pressure. We will present that the RAS has both oncogenic and tumour suppressor functions in melanoma. Furthermore, we will indicate that pharmacological inhibition of AT2R may provide therapeutic opportunities in melanomas expressing this receptor and AGTR1 CpG island methylation in serum may serve as a novel biomarker of metastatic melanoma. Furthermore, we will highlight several prodrugs and formulates that we have developed as potent anticancer agents. 7 Yeast as Oxidation-Reduction Cell Factories: From Whole Cells to Stereospecific Enzymes Anju Chadha*1,2, Vinay Kumar K1, Uma Mahesh M.V.N1, Jerrina J.P1, Leena K1, Archana
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