Conference Programme & Abstract Book Faculty of Sciences
Total Page：16
File Type：pdf, Size：1020Kb
Conference Programme & Abstract Book Faculty of Sciences, University of Lisboa, Portugal 18th July 2013 2 CONTENTS Pag. Conference Sponsors 5 Welcome FCUL/EMBL Director 7 Conference Programme 9 Poster Titles & Authors 11 Poster Abstracts 17 3 4 Institutional Sponsors Other Sponsors 5 6 Welcome Message The Faculty of Sciences, University of Lisboa (FCUL) and the European Molecular Biology Laboratory (EMBL) have organised this event dedicated to address latest developments in Molecular Biology in Portugal and at EMBL, mostly targeted for an audience of young researchers. The event aims firstly to inform life scientists at all levels in Portugal (in academia and industry) about the latest molecular biology developments in Portuguese labs and about the excellent science, facilities, training opportunities and services offered by EMBL. Secondly, the event is an excellent opportunity to further strengthen scientific links within the Portuguese community and with EMBL. EMBL and Portugal have a longstanding and a successful partnership in molecular biology and we are certain that your contribution will represent an important step towards even closer collaborations amongst Portuguese scientists as well as between Portugal and EMBL. We hope that you will enjoy this original initiative! José Pinto Paixão Iain Mattaj Director Director General Faculty of Sciences Lisbon University EMBL 7 8 Molecular Biology in Portugal and EMBL (and EMBL Alumni) Faculty of Sciences, University of Lisboa, Lisbon, 18 July 2013 Anf. 3.2.14 Programme 8.00 – 9.00 Registration of participants & poster set-up 9.00 - 9.30 Welcome address Prof. Pinto Paixão, Director of the Faculty of Sciences, University of Lisboa Prof. Miguel Seabra, FCT President Prof. Claudio Sunkel, EMBL Council Chair, EMBO Member 9.30 – 11.00 Scientific talks I. Prof. Margarida Amaral, Faculty of Sciences, University of Lisbon, EMBL Alumni Using Functional Genomics to Tackle Cystic Fibrosis Prof. Maria Carmo Fonseca, IMM Director, EMBO Member, EMBL Alumni Imaging transcription and splicing in real time Dr. Luis Teixeira, Gulbenkian Institute, EMBL Alumni, Faculty of Sciences’ Alumni Symbiont modulation of host-pathogen interactions 11.00 – 11.30 Coffee break 11.30 – 13.15 Scientific talks II. Prof. Claudina Rodrigues-Pousada, ITQB, EMBO Member Activation of the Yap8-target, ACR2 gene, requires the function of the Mediator complex in S. cerevisiae cells exposed to arsenate Dr. Rainer Pepperkok, Head of ALMF Core Facilities, EMBL Prof. Iain Mattaj, Director General EMBL: EMBL – research, services, training Dr. Gerlind Wallon, EMBO Deputy Director: EMBO – what is in it for you 13.15 – 15.15 Lunch and poster session 9 15.15 – 16.45 Scientific talks III Dr. Lars Steinmetz, Joint Head of Unit, EMBL: System Genetics Dr. Paulo Matos, Young Investigator, Faculty of Sciences, University of Lisbon Rac1 signalling in health: not too little... not too much... just enough. Dr. Reto Gassmann, IBMC, EMBO IGs 16.45 – 17.00 Poster prize and closing remarks Dr. Gerlind Wallon, EMBO Deputy Director: delivery of a Poster prize Prof. Pinto Paixão, Director of the Faculty of Sciences, University of Lisbon – Closing remarks 10 Poster Titles & Authors P.1 The role of mycobacteriophage Ms6 LysB in mycobacteria lysis Adriano Gigante, Francisco Martins, Filipa Gil and Madalena Pimentel P.2 Internal ribosome entry site-mediated translational regulation of mammalian target of rapamycin (mTOR) in stress conditions Marques-Ramos A, Lacerda R, Teixeira A, Romão L P.3 miR-34c-5p at the crossroads of human naive CD4 T-cell activation and HIV infection Ana Margarida Matos, Russell B Foxall, Andreia J Amaral, Jorge Andrade, Paula Matoso, Mariana Santa-Marta, Rita Tendeiro, Ana Serra-Caetano, Rui S Soares, João Gonçalves, Margarida Gama-Carvalho, Ana E Sousa P.4 RefirMAR, a neuromodulator bioactive ingredient derived from a deep sea microorganism: applications for daily skincare Martins A, Andrade G, Rodrigues I, Almeida A, Rodrigues C, Pinheiro R, Calado P, Vieira H. P.5 Post-transcriptional regulation of SMN2 expression by hnRNP G and LARP Family proteins Ana Miguel Fernandes, Ana Luísa Gomes, Mariana Oliveira, Gonçalo Costa, Isabel Peixeiro, Ana Margarida Matos, Carlos Cordeiro and Margarida Gama-Carvalho P.6 An approach to study glia reactivity in Amyotrophic Lateral Sclerosis Gomes C, Correia AM, Gomes R, Vaz AR, Brites D P.7 Aberrant CFTR mRNA Processing: Which Are Consequences? Anabela S Ramalho, Verónica Felício, Margarida D Amaral P.8 Amyloid-ß peptide dysregulates TrkB receptors and BDNF function by a calpain-dependent mechanism André Jerónimo-Santos, Sandra Henriques Vaz, Sara Parreira, Sofia Rapaz-Lérias, António P. Caetano, Valérie Buée-Scherrer, Eero Castrén, Claudia A. Valente, David Blum, Ana Maria Sebastião, Maria José Diógenes. P.9 An automated high-throughput screening platform to study the role of C.elegans Kinesin-5 André F. Maia, Daphne Lelieveld, Matilde Galli, David A. Egan, Marvin E.Tanenbaum, Claudio Sunkel, Sander van den Heuvel and René H. Medema P.10 Deep-sequencing profile of small ncRNAs in human CD4+ T cells upon TCR-mediated activation and its modulation by HIV infection Andreia J Amaral, Jorge Andrade, Ana Margarida Matos, Paula Matoso, Rui Soares, Russel Foxall, Rita Tendeiro, Margarida Gama-Carvalho, João Gonçalves, Ana Espada Sousa P.11 Changing laminin isoforms during skeletal muscle development: different players or a backup system? Andreia M. Nunes, André Gonçalves, Patrícia Ybot-Gonzalez, Marianne Deries & Sólveig Thorsteinsdóttir P.12 Deciphering grapevine resistance to Plasmopara viticola: hints from proteomics Andreia Figueiredo, Joana Martins, Mónica Sebastiana, Filipa Monteiro, Ana Coelho P.13 m7GDP mononucleotide is not a substrate for DcpS enzyme but might regulate its activity in vitro Anna Wypijewska, Elzbieta Bojarska, Maciej Lukaszewicz, Janusz Stepinski, Jacek Jemielity, Richard E Davis and Edward Darzynkiewicz 11 P.14 Comparative Genomics of Bacillus spp.: can core genome be the key for new therapeutics? Assessment of the core genome of Bacillus spp. and its stability Carlos Alonso, Francisco M Couto & Ricardo Dias P.15 Revertants, Low temperature and Correctors Provide Clues to Mechanism of F508del-CFTR Rescue by VX-809 and Suggest Multiple Agents for Full Correction Carlos M Farinha, John King-Underwood, Bárbara J Henriques, Ana Raquel Correia,Marisa Sousa, Jonathan Williams, Simon Hirst, Cláudio Gomes, Margarida D Amaral P.16 A novel in vitro model to study hypoxia-induced effects in retinal pigment epithelium Inês P. Rodrigues, Sara Maia, Cristiana F. Pires, Martim D. Portal,Carolina Thieleke-Matos Olaf Strauss, Miguel C. Seabra José S.Ramalho P.17 Posttranscriptional regulation of bacterial virulence Christian G Ramos, André M Grilo, Joana R. Feliciano, Paulo JP da Costa, Jorge H Leitão P.18 Translational regulation of human hemojuvelin expression via upstream open reading frames Cláudia Onofre, Cristina Barbosa, Luísa Romão P.19 Translation of the human erythropoietin transcript is regulated by an upstream open reading frame in response to hypoxia Cristina Barbosa, Luísa Romão P.20 Matching Biomedical Ontologies using External Resources Daniel Faria P.21 Dynamic expression of Notch pathway components in the ovary during the mouse estrous cycle Daniel Murta, Marta Batista, Alexandre Trindade, Elisabete Silva, Domingos Henrique, António Duarte, and Luís Lopes-da-Costa P.22 Monitoring anthracnose emergence and pathogen population dynamics in the expanding cashew tree culture in Guinea Bissau Batista D, Romeiras MM, Talhinhas P, Silva DN, Vieira A, Loureiro A, Duarte MC, Catarino L P.23 Regulation of Drug Metabolizing Enzymes and Transporters in Mouse Liver by Primaquine Gonçalves E, Marques C, Nogueira F, Rosário V, RibeiroV P.24 The role of lipid membrane in amyloid fibril formation and toxicity in Alzheimer’s disease. Eric Finot P.25 The role of Arabidopsis thaliana diacylglycerol kinase 4, in pollen tube growth and fertilization a preliminary approach." Fernando Vaz Dias, Susana Serrazina and Rui Malhó P.26 BDNF modulates type 1 cannabinoid receptor (CB1R)-stimulation of neurogenesis in murine dentate gyrus stem/progenitor cell cultures Ferreira F, Ribeiro FF, Sebastião AM, Xapelli S P.27 Evaluation of 99mTc-TMEOP as Probe for Functional Monitoring of Multidrug Resistance Filipa Mendes, Lurdes Gano, Célia Fernandes, António Paulo e Isabel Santos P.28 Uncovering basal defense response in grapevine through gene expression analysis Filipa Monteiro, Mónica Sebastiana, Andreia Figueiredo 12 P.29 A roadmap for tissue specific RNA-seq analysis of Drosophila shRNA models Francisco Brito, Andreia Amaral, Takakazu Yokokura, David van Vactor and Margarida Gama- Carvalho P.30 Ms6 Gp1 behaves as a chaperone assisting LysA delivery to its substrate Francisco Martins, Adriano Gigante, Maria João Catalão, José Moniz-Pereira and Madalena Pimentel P.31 Identification of CFTR traffic regulators as a source of novel cystic fibrosis therapeutic targets Hugo M. Botelho, Shehrazade Dahimène, Inna Uliyakina, Beate Neumann, Christian Tischer, Rainer Pepperkok, Margarida D Amaral P.32 Splicing factors in CD5 mRNA alternative polyadenylation Inês Lago-Baldaia, Nair Lopes, Inês Boal-Calvalho, Rita G Domingues, Danica Drpic, Telmo Henriques, Vânia Glória, Isabel Pereira Castro, Alexandre M Carmo, Alexandra Moreira P.33 Hydrogen Peroxide sensor in an anaerobic bacterium: Desulfovibrio vulgaris Hildenborough PerR Vasco Ribeiro, Isabel Silva, David Sardinha, Alice Pereira, Pedro Tavares and Cristina