DOCSLIB.ORG

Because Research Will Beat Blood Cancer

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Because Research Will Beat Blood Cancer Because research will beat blood cancer 1 Blood Cancer UK Research Strategy “Research is at the heart of what we do as an organisation. Over the last 60 years, we have invested over £500 million in research and this has led to key research discoveries that have changed the lives of people affected by blood cancer. Thanks to this extraordinary progress, we believe it’s now possible to beat blood cancer in a generation. This research strategy will ensure our funds have the biggest impact possible for our community, and crucially that we reach the day when we beat it as soon as possible.” Gemma Peters, CEO of Blood Cancer UK 2 Blood Cancer UK Research Strategy Our research strategy in summary The millions of pounds we invest in world We will also introduce a cross cutting class research each year, is all thanks to scheme, that will allow us to support Blood Cancer UK’s incredible community, initiatives and research programmes many of whom are personally affected by across blood cancers. blood cancer. Our shared goal is to beat blood cancer through research. Investing in partnership with other funders will facilitate greater impact from existing This research strategy sets out an blood cancer research spend and bring overarching approach to our future new investment into blood cancer research. research investment, and our short term priorities. These will always be guided by Blood Cancer UK has had a strong a focus on both impact, and what matters track record in funding for early career to people affected by blood cancer. researchers, and we will introduce a new fellowship scheme to support career We will fund across a diverse portfolio, development, to ensure the most talented allowing us to take risks, respond to researcher are supported to work in the emergent opportunities and partner with blood cancer field. others on common goals. This portfolio will include competitive project grant “We need to give people good years on the funding against a set of defined priorities. clock, as opposed to just number of years” Gordon Cook, Professor of Haematology & Myeloma Studies, University of Leeds 3 Blood Cancer UK Research Strategy Our vision & mission We’re here to beat blood cancer, “If cancer research were a comet, blood and research will get us there. cancer research would be the brightest part at the leading edge. Many of the Over the last 60 years we have proved paradigm shifts in cancer research have that blood cancer research saves lives, come from research into blood cancer: but now we need to finish the job. We need to discover more about how blood chemotherapy, targeted therapies, cancers evolve, develop, and are best monoclonal antibodies, CAR-T…etc” treated. We need treatments with fewer Chris Bunce, Professor of Translational side effects and better outcomes for Cancer Biology, University of Birmingham people affected by blood cancer. We want a world where we can predict how It is also true that developments in blood a disease will progress, so that we can cancer have benefited other cancers and stop blood cancer in its tracks. Because biomedical science. In blood cancer, we’ve the more we understand it, the more lives identified the “cancer stem cell” responsible we can save. for generating a stream of cancer cells and causing drug resistance. Many cancer Blood Cancer UK is the largest sole blood researchers across the globe are now trying cancer research funder in the UK. Funding to find treatments that target these cells. research which has an impact across all blood cancers is particularly important As Blood Cancer UK we will always put part of our strategy. Blood cancers are what matters to people affected by blood interconnected, as is the experience of cancer first. We are in a unique position people affected by blood cancer and to bring together our community inculding the clinicians who treat them. researchers and health care professionals to invest in the best quality science that For example, chronic lymphocytic will lead to the advances in treatment and leukaemia (CLL) can transform to non- outcomes. Because we’re stronger together. Hodgkin lymphoma and myelodysplastic syndromes (MDS) to acute myeloid leukaemia (AML). We know from previous discoveries that new treatments in one blood cancer go on to work in others, for example CAR-T. 4 Blood Cancer UK Research Strategy Why create a research strategy and why now? We have a long history of investing in Through the development of the research blood cancer research and a current grant strategy, we have identified areas of portfolio worth around £40 million. This scientific opportunity where our focused includes research projects, cell banks and investment will further accelerate research clinical trials. This research has led to huge progress. This will also enable us to develop developments in our understanding of blood partnerships, so that we can ensure the best cancers, but we know that we need to do possible outcomes for people with more if we’re going to beat blood cancer blood cancer. within a generation. This work began before the current Covid-19 In recent years we’ve seen step changes in pandemic. But the pandemic is likely to have the way blood cancers are diagnosed and a long-term impact on research. In the short treated. For example, identifying key genetic term, all funding organisations will have less switches has had a real impact on outcomes to invest and sadly, some researchers are for people affected by blood cancer. Recent exiting the field as a result. Blood Cancer UK advances in technology mean we can now needs to protect and support our research better analyse, understand and build on community. But there are likely to be longer previous scientific discoveries, providing term changes to research in the UK after a platform for the acceleration of the pandemic, so we need an approach to new treatments. funding research which is agile and flexible. 5 Blood Cancer UK Research Strategy How we developed our research strategy Held ERG Research strategy Engaged an workshops on options reined into a Final Board of Expert Reference patient themes new set of options Trustees approval and recommendation Group (ERG) and prominent and sign off May 2020 scientiic themes December 2020 – January 2021 April 2021 August 2020 Identiied ive key Recruited a questions to High level option Patient Held PRP further develop the recommendation Reference workshops research strategy presented to Panel (PRP) to prioritise (explored with the Board April – May 2020 themes ERG and PRP) of Trustees July 2020 September – November January 2021 2020 Launched questionnaires to Analysed NCRI get feedback from funding data a broader range of Held 1-2-1 with ERG Research strategy alongside HMRN researchers and Recommended and PRP members to people affected by option tested launched to statistics to look at research get their thoughts on Engaged all blood cancer with ERG and historic blood November 2020 Research community Blood Cancer UK’s stakeholders with June 2021 cancer funding Strategy Advisory potential research draft research trends Committee priorities strategy options (RSAC) April – August 2020 September – November June – July 2020 January 2021 2020 Over the last year, we’ve spoken to “Nothing about us without us, to quote researchers and people affected by blood the well-known phrase. Being involved in cancer to understand the top priorities and this process has helped me understand upcoming advances in research. Working just how important the patient voice is to collaboratively, we have developed a new strategy for our investment in research, Blood Cancer UK. We have been listened to one that we believe will accelerate the at every step and it has been an intensely rate of progress so people with blood rewarding process to be part of.” cancer can benefit sooner. Ally Boyle, diagnosed with myelodysplastic syndrome (MDS) in 2008 We brought together a group of people affected by blood cancer and a group of blood cancer researchers and clinicians for in depth discussions on potential priority areas for blood cancer research. We also ran online workshops to engage wider groups and ensure we received a diverse range of thoughts and opinions. We consulted broadly with the research community and people affected by blood cancer to ensure our decision making was grounded in the expertise of our communities. 6 Blood Cancer UK Research Strategy Our core strategic principles Across our portfolio, Blood Cancer UK is “I’m currently in remission from Hodgkin committed to funding excellent quality lymphoma, and don’t know when to scientific research that will improve our be worried. I live with the fear and understanding of blood cancers, lead to worry of relapse.” the development of new treatments with Ruchi Shrivastava, diagnosed fewer side effects and will ensure that more people survive. As a result of the research with Hodgkin lymphoma in 2015 strategy development process, Blood Cancer UK will focus on doing five things: 4. Putting people affected by blood cancer at the heart of research 1. Working in partnership People affected by blood cancer have We will actively seek to work with other guided the development of this research charities, industry and partners who share strategy and we will continue to ensure their common goals, in the UK and internationally. voice is central to our research. “Working in partnerships is so important to “Everyone’s blood cancer is their own, make the most of the funding available and everyone’s experience is different.” achieve more for patients” Katharine Harries, mother to Max, Irene Roberts, Professor of Paediatric diagnosed with acute myeloid Haematology, Oxford University leukaemia (AML) at 3 months 2. Driving innovation 5. Working collaboratively with Our researcher and patient community will researchers continue to shape our priorities.
Load more

Recommended publications
  • Low-Grade Non-Hodgkin Lymphoma Book
    Low-grade non-Hodgkin lymphoma Low-grade non-Hodgkin lymphoma Follicular lymphoma Mantle cell lymphoma Marginal zone lymphomas Lymphoplasmacytic lymphoma Waldenström’s macroglobulinaemia This book has been researched and written for you by Lymphoma Action, the only UK charity dedicated to people affected by lymphoma. We could not continue to support you, your clinical team and the wider lymphoma community, without the generous donations of our incredible supporters. As an organisation we do not receive any government or NHS funding and so every penny received is truly valued. To make a donation towards our work, please visit lymphoma-action.org.uk/Donate 2 Your lymphoma type and stage Your treatment Key contact Name: Role: Contact details: Job title/role Name and contact details GP Consultant haematologist/ oncologist Clinical nurse specialist or key worker Treatment centre 3 About this book Low-grade (or indolent) non-Hodgkin lymphoma is a type of blood cancer that develops from white blood cells called lymphocytes. It is a broad term that includes lots of different types of lymphoma. This book explains what low-grade non-Hodgkin lymphoma is and how it is diagnosed and treated. It includes tips on coping with treatment and dealing with day-to-day life. The book is split into chapters. You can dip in and out of it and read the sections that are relevant to you at any given time. Important and summary points are written in the chapter colour. Lists practical tips and chapter summaries. Gives space for questions and notes. Lists other resources you might find useful, some of which are online.
    [Show full text]
  • High-Grade Non-Hodgkin Lymphoma (NHL)
    High-grade non-Hodgkin lymphoma (NHL) A guide to DLBCL and other fast-growing non-Hodgkin lymphomas About this booklet We have produced this booklet in collaboration with expert medical professionals and people affected by blood cancer. Thank you to Consultant Haematologists Dr Kirit Ardeshna and Professor Tim Illidge, and Clinical Nurse Specialist Claire Barton, for their support checking the content of this booklet. We’re a community dedicated to beating blood cancer by funding research and supporting those affected. Since 1960, we’ve invested over £500 million in blood cancer research, transforming treatments and saving lives. To find out more about what we do, see page 109. bloodcancer.org.uk 0808 2080 888 (Mon, Tue, Thu, Fri, 10am–4pm, Wed, 10am–1pm) [email protected] A list of references used in this booklet is available on request. Please email us at [email protected] Disclaimer We make every effort to make sure that the information in this booklet is accurate, but you shouldn’t rely on it instead of a fully trained clinician. It’s important to always listen to your specialist and seek advice if you have any concerns or questions about your health. Blood Cancer UK can’t accept any loss or damage resulting from any inaccuracy in this information, or from external information that we link to. The information in this booklet is correct at the time it was printed (June 2018). Date of next review: June 2021. Blood Cancer UK, 39–40 Eagle Street, London WC1R 4TH 020 7504 2200 [email protected] bloodcancer.org.uk © All rights reserved.
    [Show full text]
  • Chronic Myeloid Leukaemia (CML)
    Chronic myeloid leukaemia (CML) About this booklet We have produced this booklet in collaboration with expert medical professionals and people affected by blood cancer. Thank you to Consultant Haematologists Professor Jane Apperley and Dr Dragana Milojkovic; and Clinical Nurse Specialist Irene Caballes for their support checking the content of this booklet. We’re a community dedicated to beating blood cancer by funding research and supporting those affected. Since 1960, we’ve invested over £500 million in blood cancer research, transforming treatments and saving lives. To find out more about what we do, see page 105. bloodcancer.org.uk 0808 2080 888 (Mon, Tue, Thu, Fri, 10am–4pm, Wed, 10am–1pm) [email protected] A list of references used in this booklet is available on request. Please email us at [email protected] Disclaimer We make every effort to make sure that the information in this booklet is accurate, but you shouldn’t rely on it instead of a fully trained clinician. It’s important to always listen to your specialist and seek advice if you have any concerns or questions about your health. Blood Cancer UK can’t accept any loss or damage resulting from any inaccuracy in this information, or from external information that we link to. The information in this booklet is correct at the time it was printed (January 2019) Date of next review: January 2022 Blood Cancer UK, 39–40 Eagle Street, London WC1R 4TH 020 7504 2200 [email protected] bloodcancer.org.uk © All rights reserved. No part of this publication can be reproduced or transmitted without permission in writing from Blood Cancer UK.
    [Show full text]
  • Acute Lymphoblastic Leukaemia
    Acute lymphoblastic leukaemia (ALL) About this booklet We have produced this booklet in collaboration with expert medical professionals and people affected by blood cancer. Thank you to Consultant Haematologists Professor Adele Fielding and Dr Clare Rowntree for their support checking the content of this booklet. We’re a community dedicated to beating blood cancer by funding research and supporting those affected. Since 1960, we’ve invested over £500 million in blood cancer research, transforming treatments and saving lives. To find out more about what we do, see page 115. bloodcancer.org.uk 0808 2080 888 (Mon, Tue, Thu, Fri, 10am–4pm, Wed, 10am–1pm) [email protected] A list of references used in this booklet is available on request. Please email us at [email protected] Disclaimer We make every effort to make sure that the information in this booklet is accurate, but you shouldn’t rely on it instead of a fully trained clinician. It’s important to always listen to your specialist and seek advice if you have any concerns or questions about your health. Blood Cancer UK can’t accept any loss or damage resulting from any inaccuracy in this information, or from external information that we link to. The information in this booklet is correct at the time it was printed (February 2019) Date of next review: 2022 Blood Cancer UK, 39–40 Eagle Street, London WC1R 4TH 020 7504 2200 [email protected] bloodcancer.org.uk © All rights reserved. No part of this publication can be reproduced or transmitted without permission in writing from Blood Cancer UK.
    [Show full text]
  • T(8;21) Acute Myeloid Leukemia As a Paradigm for the Understanding of Leukemogenesis at the Level of Gene Regulation and Chromatin Programming
    cells Review t(8;21) Acute Myeloid Leukemia as a Paradigm for the Understanding of Leukemogenesis at the Level of Gene Regulation and Chromatin Programming 1, 1, 2, 1, Sophie Kellaway y, Paulynn S. Chin y , Farnaz Barneh y, Constanze Bonifer * and Olaf Heidenreich 2,* 1 Institute of Cancer and Genomica Sciences, College of Medicine and Dentistry, University of Birmingham, Birmingham B152TT, UK; [email protected] (S.K.); [email protected] (P.S.C.) 2 Princess Máxima Centrum for Pediatric Oncology, Heidelberglaan 25, 3584CS Utrecht, The Netherlands; [email protected] * Correspondence: [email protected] (C.B.); [email protected] (O.H.) Equal contribution. y Received: 23 November 2020; Accepted: 9 December 2020; Published: 13 December 2020 Abstract: Acute myeloid leukemia (AML) is a heterogenous disease with multiple sub-types which are defined by different somatic mutations that cause blood cell differentiation to go astray. Mutations occur in genes encoding members of the cellular machinery controlling transcription and chromatin structure, including transcription factors, chromatin modifiers, DNA-methyltransferases, but also signaling molecules that activate inducible transcription factors controlling gene expression and cell growth. Mutant cells in AML patients are unable to differentiate and adopt new identities that are shaped by the original driver mutation and by rewiring their gene regulatory networks into regulatory phenotypes with enhanced fitness. One of the best-studied AML-subtypes is the t(8;21) AML which carries a translocation fusing sequences encoding the DNA-binding domain of the hematopoietic master regulator RUNX1 to the ETO gene. The resulting oncoprotein, RUNX1/ETO has been studied for decades, both at the biochemical but also at the systems biology level.
    [Show full text]
  • Rapid Access to New Drugs and Treatments for People with Blood Cancer on the Nhs Foreword
    RAPID ACCESS TO NEW DRUGS AND TREATMENTS FOR PEOPLE WITH BLOOD CANCER ON THE NHS FOREWORD On behalf of the whole membership of the medicines and treatments is, therefore, critical Blood Cancer Alliance, I would like to thank to improving patient outcomes. you for taking the time to read this important new research report. The research contained in this report identifies that patient access to new and effective There are currently over 240,000 people in treatment is still variable across the UK. We the UK living with blood cancer. It is the fifth outline ten issues that are exacerbating this most prevalent cancer in our country, and the problem. The policy recommendations we third biggest cancer killer. Improving outcomes are making are by no means radical. They for blood cancer patients - both in terms of represent changes that agencies such as disease survival and quality of life – is the the National Institute for Health and Care ambition that drives the Blood Cancer Alliance, Excellence (NICE), the Scottish Medicines with our member organisations working Consortium (SMC), commissioners and the individually and collectively towards this goal pharmaceutical industry can make to their every single day. practices that would improve access to blood cancer treatments. We expect that many The Blood Cancer Alliance commissioned this would also aid access to treatments for all research in order to strengthen the evidence patients as it matters that patients are involved base for how, by making positive policy every step of the way; from development changes with regard to new blood cancer through to prescription in the NHS.
    [Show full text]
  • Chronic Lymphocytic Leukaemia (CLL)
    Chronic lymphocytic leukaemia (CLL) About this booklet We have produced this booklet in collaboration with expert medical professionals and people affected by blood cancer. Thank you to Dr Samir Agrawal, Dr Claire Dearden, Clinical Nurse Specialist Lucy Whiteman and the CLL Support Association for their support checking the content of this booklet. We’re a community dedicated to beating blood cancer by funding research and supporting those affected. Since 1960, we’ve invested over £500 million in blood cancer research, transforming treatments and saving lives. To find out more about what we do, see page 97. bloodcancer.org.uk 0808 2080 888 (Mon, Tue, Thu, Fri, 10am–4pm, Wed, 10am–1pm) [email protected] A list of references used in this booklet is available on request. Please email us at [email protected] Disclaimer We make every effort to make sure that the information in this booklet is accurate, but you shouldn’t rely on it instead of a fully trained clinician. It’s important to always listen to your specialist and seek advice if you have any concerns or questions about your health. Blood Cancer UK can’t accept any loss or damage resulting from any inaccuracy in this information, or from external information that we link to. The information in this booklet is correct at the time it was printed (July 2017) In July 2019, we made some edits to update information on some of the treatments. Date of next full review: July 2020. Blood Cancer UK, 39–40 Eagle Street, London WC1R 4TH 020 7504 2200 [email protected] bloodcancer.org.uk © All rights reserved.
    [Show full text]
  • Our Impact Over 60 Years 1
    Blood Cancer UK: Our Impact over 60 Years 60 years of life-saving research 1 Blood Cancer UK: Our Impact over 60 Years Blood Cancer UK: Our Impact over 60 Years Foreword The report you’re about to read tells the story Our story is made up of thousands of people, of the research we’ve funded and the lives that who each have their own story to tell, and who have been saved over the last 60 years. continue to play a vital role in shaping our charity’s story. It’s the story of scientific breakthroughs that have collectively changed the world for people with The other thing that occurred to me as I read blood cancer. It tells you how blood cancer has this report, is that it is missing a final chapter. It gone from a condition that was almost always ends at the point in the story where outcomes for a death sentence, to one that can often be put people with blood cancer have been improved into long-term remission or lived with as a dramatically, but there is still much more to long-term condition. be done. It’s a story of ingenuity, determination and Blood cancer still claims 15,000 lives a year in sometimes luck. A story of how each generation the UK and many more people have to endure of researchers has built on the breakthroughs of the side effects of harsh treatments. previous ones. We’re now at the point where the day we beat As I read this report, I feel hugely proud of what blood cancer is finally in sight.
    [Show full text]
  • Young Person's Guide to Lymphoma Digital
    Raveen, diagnosed at 23 Dwayne, diagnosed at 25 Young person’s guide to lymphoma Callum, diagnosed at 21 Tamsin, diagnosed at 16 My diagnosis My lymphoma type and stage Key worker contact details My treatment 2 Who we are We’re Lymphoma Action, a UK charity that provides specialist information and support to help people affected by lymphoma. We hope you feel more in control, more confident and better connected to help you cope with your diagnosis. We follow best practice guidelines to make sure we produce reliable, high quality information. We've written this book in collaboration with expert medical advisors. We are also grateful to the young people affected by lymphoma who reviewed and helped with this publication. To find out more about us and to look for more information· onhead any of the topics in this book to lymphoma-action.org.uk Who we are How to use this book Who’s it for? If you are a young person with lymphoma, this book is for you. Use it however it best helps you: write in it; take it to appointments; share it with friends and family. What’s inside? This book tells you what lymphoma is and what to expect during and after treatment. It answers some of the common questions young people have and offers tips on looking after yourself. You don’t have to read it all at once or in any particular order. Some sections might not be relevant for the type of lymphoma you have; others might become relevant only after you’ve been through treatment.
    [Show full text]
  • Low-Grade Non-Hodgkin Lymphoma (NHL)
    Low-grade non-Hodgkin lymphoma (NHL) A guide to follicular lymphoma and other slow-growing non-Hodgkin lymphomas About this booklet We have produced this booklet in collaboration with expert medical professionals and people affected by blood cancer. Thank you to Dr Robert Marcus, Dr John de Vos and Dr Chin Neoh for their support checking the content of this booklet. We’re a community dedicated to beating blood cancer by funding research and supporting those affected. Since 1960, we’ve invested over £500 million in blood cancer research, transforming treatments and saving lives. To find out more about what we do, see page 105. bloodcancer.org.uk 0808 2080 888 (Mon, Tue, Thu, Fri, 10am–4pm, Wed, 10am–1pm) [email protected] A list of references used in this booklet is available on request. Please email us at [email protected] Disclaimer We make every effort to make sure that the information in this booklet is accurate, but you shouldn’t rely on it instead of a fully trained clinician. It’s important to always listen to your specialist and seek advice if you have any concerns or questions about your health. Blood Cancer UK can’t accept any loss or damage resulting from any inaccuracy in this information, or from external information that we link to. The information in this booklet is correct at the time it was printed (August 2018). Date of next review: August 2021 Blood Cancer UK, 39–40 Eagle Street, London WC1R 4TH 020 7504 2200 [email protected] bloodcancer.org.uk © All rights reserved.
    [Show full text]
  • Myeloproliferative Neoplasms (MPN)
    Myeloproliferative neoplasms (MPN) About this booklet We have produced this booklet in collaboration with expert medical professionals and people affected by blood cancer. Thank you to Professor Tony Green, Dr Jacob Grinfeld, Dr Jyoti Evans, Dr Will Thomas and Clinical Nurse Specialists Vashti Ragoonanan, Yvonne Francis, Siobban McGuckin and Millicent Blake-McCoy for their support checking the content of this booklet. We’re a community dedicated to beating blood cancer by funding research and supporting those affected. Since 1960, we’ve invested over £500 million in blood cancer research, transforming treatments and saving lives. To find out more about what we do, see page 113. bloodcancer.org.uk 0808 2080 888 (Mon, Tue, Thu, Fri, 10am–4pm, Wed, 10am–1pm) [email protected] A list of references used in this booklet is available on request. Please email us at [email protected] Disclaimer We make every effort to make sure that the information in this booklet is accurate, but you shouldn’t rely on it instead of a fully trained clinician. It’s important to always listen to your specialist and seek advice if you have any concerns or questions about your health. Blood Cancer UK can’t accept any loss or damage resulting from any inaccuracy in this information, or from external information that we link to. The information in this booklet is correct at the time it was printed (March 2015). In January 2019 we made some edits, which included updated information on busulfan, ruxolitinib and hydroxycarbamide. Date of next full review 2020. Blood Cancer UK, 39–40 Eagle Street, London WC1R 4TH 020 7504 2200 [email protected] bloodcancer.org.uk © All rights reserved.
    [Show full text]
  • High-Grade Non-Hodgkin Lymphoma
    High-grade non-Hodgkin lymphoma High-grade non-Hodgkin lymphoma Diffuse large B-cell lymphoma Burkitt lymphoma Double-hit and triple-hit lymphoma Central nervous system lymphoma Other high-grade B-cell lymphomas T-cell lymphomas This book has been researched and written for you by Lymphoma Action, the only UK charity dedicated to people affected by lymphoma. We could not continue to support you, your clinical team and the wider lymphoma community, without the generous donations of our incredible supporters. As an organisation we do not receive any government or NHS funding and so every penny received is truly valued. To make a donation towards our work, please visit lymphoma-action.org.uk/Donate 2 Your lymphoma type and stage Your treatment Key contact Name: Role: Contact details: Job title/role Name and contact details GP Consultant haematologist/ oncologist Clinical nurse specialist or key worker 3 About this book High-grade (or aggressive) non-Hodgkin lymphoma is a type of blood cancer that develops from white blood cells called lymphocytes. It is a broad term that includes lots of different types of lymphoma. This book explains what high-grade non-Hodgkin lymphoma is and how it is diagnosed and treated. It includes tips on coping with treatment and day-to-day life. The book is split into chapters. You can dip in and out of it and read the sections that are relevant to you at any given time. Important and summary points are written in the chapter colour. Lists practical tips and chapter summaries. Gives space for questions and notes.
    [Show full text]