1 The ENIGMA Brain Injury Working Group: Approach, Challenges, and Potential Benefits Elisabeth A. Wilde1,2,3, Emily L. Dennis1,2,4,5, David F. Tate1,2,6 1Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT 2George E. Wahlen VA Medical Center, Salt Lake City, UT 3H. Ben Taub Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX 4Psychiatry Neuroimaging Laboratory, Brigham & Women’s Hospital, Harvard Medical School, Boston, MA 5Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA 6Missouri Institute of Mental Health, University of Missouri, St. Louis, MO Please address correspondence to: Dr. Emily L Dennis TBICC, Dept of Neurology University of Utah School of Medicine
[email protected] 2 Abstract The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) consortium brings together researchers from around the world to try to identify the genetic underpinnings of brain structure and function, along with robust, generalizable effects of neurological and psychiatric disorders. The recently-formed ENIGMA Brain Injury working group includes 10 subgroups, based largely on injury mechanism and patient population. This introduction to the special issue summarizes the history, organization, and objectives of ENIGMA Brain Injury, and includes a discussion of strategies, challenges, opportunities and goals common across 6 of the subgroups under the umbrella of ENIGMA Brain Injury. The following articles in this special issue, including 6 articles from different subgroups, will detail the challenges and opportunities specific to each subgroup. Introduction to ENIGMA The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA; enigma.usc.edu) consortium was formed in 2009 in an effort to increase power to detect associations between genetic variation and brain structure and function.