Cannabis in Colorado: Dispatches from the Green Revolution Contents
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9-THC Disrupts Gamma (Γ)&Ndash;Band Neural
UCSF UC San Francisco Previously Published Works Title Δ9-THC Disrupts Gamma (γ)-Band Neural Oscillations in Humans Permalink https://escholarship.org/uc/item/6ms753gw Journal Neuropsychopharmacology, 40(9) ISSN 0893-133X Authors Cortes-Briones, J Skosnik, PD Mathalon, D et al. Publication Date 2015-08-16 DOI 10.1038/npp.2015.53 Peer reviewed eScholarship.org Powered by the California Digital Library University of California Accepted Article Preview: Published ahead of advance online publication D9-THC Disrupts Gamma (c)–Band Neural Oscillations in Neuropsychopharmacology www.neuropsychopharmacology.org Humans Jose Cortes-Briones, Patrick D Skosnik, Daniel Mathalon, Methylphenidate modifies the motion of the circadian clock Lamotrigine in mood disorders and cocaine dependence John Cahill, Brian Pittman, Ashley Williams, R Andrew Cortical glutamate in postpartum depression Sewell, Mohini Ranganathan, Brian Roach, Judith Ford, Deepak Cyril D’Souza Cite this article as: Jose Cortes-Briones, Patrick D Skosnik, Daniel Mathalon, John Cahill, Brian Pittman, Ashley Williams, R Andrew Sewell, Mohini Ranganathan, Brian Roach, Judith Ford, Deepak Cyril D’Souza, D9-THC Disrupts Gamma (g)–Band Neural Oscillations in Humans, Neuropsychopharma- cology accepted article preview 24 February 2015; doi: 10.1038/npp.2015.53. This is a PDF file of an unedited peer-reviewed manuscript that has been accepted for publication. NPG are providing this early version of the manuscript as a service to our customers. The manuscript will undergo copyediting, typesetting and a proof review before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers apply. -
Compendium of Drug Abuse Jargon
Compendium of Drug Abuse Jargon Ronald P. Evens, PharmD William Clementi, BS (Pharm) San Antonio and Austin, Texas Drug abuse slang is an originative and a protean language, which poses the problem of identification and definition of terms. This compilation of nomenclature provides an extensive list to serve as a resource for the busy family physician, who frequently deals with drug abuse problems. Despite efforts by the government encompassing the following abuse The list on the following pages is and in the private sector to identify agents: alcohol, glue, hallucinogens, organized in alphabetical sequence drug abuse problems and collate the narcotics, sedative-hypnotics, and according to the drug abuse term. terminology of the “drug culture,” the stimulants; and the street slang em resultant lists of nomenclature usually ployed in association with their distri References describe only the “top 100 or 50” bution and administration, and 1. Konner DD, Rubin I: The pharma terms. This severely limits their useful reactions to them. cist's drug abuse manual. Pharmacy Times 39:35-37, 1973 ness as a resource tool because a The difficulty in comprehension of 2. Narcotics Identification Guide. significant proportion of the terms are this specialized lingo is primarily due Richmond, Va, Jump Street, The Drug Treatment Program of the Medical College already familiar to practitioners while to its protean nature and the continual of Virginia, 1970 generation of new terms. Different 3. Some Substances Used for Non- a vastly greater number of terms in use prescribed Drugging Effects. Washington, do not appear on the lists at all. subpopulations in the drug abuse cul DC, Pharmaceutical Manufacturers Associa tion, January, 1973 Therefore, we have accumulated and ture use dissimilar, changeable subsets 4. -
City of Santa Monica Policy on Alcohol Use and Controlled Substances for Certain Holders of Commercial Driver's Licenses
REVISED/ISSUED NOV. 2009 CITY OF SANTA MONICA POLICY ON ALCOHOL USE AND CONTROLLED SUBSTANCES FOR CERTAIN HOLDERS OF COMMERCIAL DRIVER’S LICENSES SECTION CONTENTS Subpart A – General Page 3 Purpose Scope Definitions Responsibilities Requirement for Notice Employee admission of alcohol and controlled substance abuse Subpart B – Prohibitions Page 9 Alcohol Concentrations On-Duty-Use Pre-Duty Use Use following an accident Refusal to Submit to a required alcohol or controlled substance test Controlled Substance Use Controlled Substances Testing Subpart C – Tests Required Page 10 Pre-employment Testing Post-Accident Testing Random Testing Reasonable Suspicion Testing Return-to-Duty Testing Follow-up Testing Mandatory Direct Observation Collection Procedures Bi-Annual Medical Certificate Renewals 1 Subpart D – Handling of Tests Results, Records, Retention, and Confidentiality Page 17 Test Result Protocol, Records Retention, Types of Records, Confidentiality Reporting of Results in a Management Information System Access to facilities and records Medical Review Officer Responsibilities Subpart E – Consequences of Positive Test Results Page 21 Removal from Safety Sensitive Functions Last Chance Agreement Other Disciplinary Action Subpart F – Training of Drivers and Supervisors Page 22 Appendices A. Job classifications affected by this policy Page 23 B. DOT‟s Direct Observation Procedures Page 24 C. Alcohol and Controlled Substances fact sheets Page 25 2 SUBPART A – GENERAL PURPOSE The purpose of this policy is to protect employees and the public in complying with Federal Motor Carrier Safety Administration laws (49 CFR Parts 40 and 382), the California Drug-Free Workplace Act of 1991, and the City of Santa Monica Municipal Code Section 2.04.420(e) which prohibits employees from reporting for duty or being on duty while under the influence of alcohol or controlled substances; and to establish programs designed to help prevent accidents and injuries resulting from the misuse of alcohol or use of controlled substances by City drivers of commercial motor vehicles. -
Selling Cannabis Regulation: Learning from Ballot Initiatives in the United States in 2012
ISSN 2054-1910 Selling cannabis regulation: Learning From Ballot Initiatives in the United States in 2012 Emily Crick*, Mark Cooke¥ and Dave Bewley-Taylorp Policy Brief 6 | November 2014 Key Points • In November 2012, Washington, Colorado, and Oregon voted on ballot initiatives to establish legally regulated markets for the production, sale, use and taxation of cannabis.1 Washington and Colorado’s measures won by wide margins, while Oregon’s lost soundly. • A majority of voters view cannabis in a negative light, but also feel that prohibition for non-medical and non-scientific purposes is not working. As a result, they are more likely to support well-crafted reform policies that include strong regulations and direct tax revenue to worthy causes such as public health and education. • Ballot measures are not the ideal method for passing complicated pieces of legislation, but sometimes they are necessary for controversial issues. Other states often follow in their footsteps, including via the legislature. • The successful campaigns in Washington and Colorado relied on poll-driven messaging, were well organised, and had significant financing. The Oregon campaign lacked these elements. • The Washington and Colorado campaigns targeted key demographic groups, particularly 30-50 year old women, who were likely to be initially supportive of reform but then switch their allegiance to the ‘no’ vote. • Two key messages in Washington and Colorado were that legalisation, taxation and regulation will (i) free up scarce law enforcement resources to focus on more serious crimes and (ii) will create new tax revenue for worthy causes. • National attitudes on legalising cannabis are changing, with more and more people supporting reform. -
Tasty THC: Promises and Challenges of Cannabis Edibles
RTI Press Occasional Paper November 2016 Tasty THC: Promises and Challenges of Cannabis Edibles Daniel G. Barrus, Kristen L. Capogrossi, Sheryl C. Cates, Camille K. Gourdet, Nicholas C. Peiper, Scott P. Novak, Timothy W. Lefever, and Jenny L. Wiley RTI Press publication OP-0035-1611 This PDF document was made available from www.rti.org as a public service of RTI International. More information about RTI Press can be found at http://www.rti.org/rtipress. RTI International is an independent, nonprofit research organization dedicated to improving the human condition by turning knowledge into practice. The RTI Press mission is to disseminate information about RTI research, analytic tools, and technical expertise to a national and international audience. RTI Press publications are peer- reviewed by at least two independent substantive experts and one or more Press editors. Suggested Citation Barrus, D.G., Capogrossi, K.L., Cates, S.C., Gourdet, C.K., Peiper, N.C., Novak, S.P., Lefever, T.W., and Wiley, J.L. (2016). Tasty THC: Promises and Challenges of Cannabis Edibles. RTI Press Publication No. OP-0035-1611. Research Triangle Park, NC: RTI Press. http://dx.doi.org /10.3768/rtipress.2016.op.0035.1611 This publication is part of the RTI Press Research Report series. Occasional Papers are scholarly essays on policy, methods, or other topics relevant to RTI areas of research or technical focus. RTI International 3040 East Cornwallis Road PO Box 12194 ©2016 RTI International. All rights reserved. Credit must be provided to the author and source of the Research Triangle Park, NC publication when the content is quoted. -
The Legalization of Marijuana in Colorado: the Impact Vol
The Legalization of Marijuana in Colorado: The Impact Vol. 4/September 2016 PREPARED BY: ROCKY MOUNTAIN HIDTA INVESTIGATIVE SUPPORT CENTER STRATEGIC INTELLIGENCE UNIT INTELLIGENCE ANALYST KEVIN WONG INTELLIGENCE ANALYST CHELSEY CLARKE INTELLIGENCE ANALYST T. GRADY HARLOW The Legalization of Marijuana in Colorado: The Impact Vol. 4/September 2016 Table of Contents Acknowledgements Executive Summary ............................................................................................ 1 Purpose ..................................................................................................................................1 State of Washington Data ...................................................................................................5 Introduction .......................................................................................................... 7 Purpose ..................................................................................................................................7 The Debate ............................................................................................................................7 Background ...........................................................................................................................8 Preface ....................................................................................................................................8 Colorado’s History with Marijuana Legalization ...........................................................9 Medical Marijuana -
Cannabis Pest Management - a Perspective from Colorado Cultivated Cannabis Involves the Use of Two Species (Subspecies?) That Freely Interbreed
Cannabis Pest Management - A Perspective from Colorado Cultivated Cannabis involves the use of two species (subspecies?) that freely interbreed Cannabis indica Cannabis sativa What type of crop is cannabis? Types of Cannabis Crops • Medical/Recreational Use –Marijuana • CBD (cannabidiol) Production –Non-psychoactive extracts • Hemp grown for seed, fiber Present Status of State Laws Regarding Legality of Medical and/or Recreational Marijuana Key Colorado State Laws Regarding Cannabis • November 2000 – Passage of Amendment 20 – Allows usage of Cannabis for patients with written medical permission (“medical marijuana”) – Patients may grow up to 6 plants – Patients may acquire Cannabis from a caregiver or from non-state affiliated clubs/organizations (dispensaries) Some Background – Key Date • November 2012 – Passage of Amendment 64 – Allows personal use of Cannabis for all uses (e.g., recreational use) – Establishes regulations on production and sale of Cannabis – Directed that a system be established to allow hemp production within the state Marijuana Production • Involves C. sativa, C. indica and hybrids • Primary compound THC – Secondary cannabinoids often important • End uses – Whole buds (inhaled) – Extracts • Edibles • Inhalation (vaping) • Salves, ointments 10 mg THC is standardized serving size Each plant is tagged and tracked through the entire production stage – through end point distribution. The crop is clonally propagated – all female plants. Culture is with drip irrigation into pots or through hydroponic production Medical/Recreational -
Cannabis-Find-Out-The-Facts.Pdf
cannabis FIND OUT THE FACTS FRANK_Cannabis Facts_3.indd 1 06/04/2009 14:02 “Cannabis can’t be “It’s no big deal. Most harmful because it people use cannabis comes from a plant these days.” so it’s natural.” “Smoking cannabis puts “It’s OK to smoke you on a slippery slope cannabis in the to using harder drugs.” street – you'll only get a warning.” Some people seem to think they know a lot about cannabis… FRANK_Cannabis Facts_3.indd 2 06/04/2009 14:03 ...but how can you tell the facts from the fiction? FACT: Cannabis can FACT: After alcohol and cause health problems tobacco, cannabis is the both physical and mental, most commonly used drug including things like anxiety in the UK. But most people and paranoia. Just because AREN’T using it. Less than it’s from a plant doesn’t one in eight adults (aged mean it’s harmless. 16-59) and less than one in five young people (aged FACT: Cannabis is illegal. 16-24) say they have used It’s a Class B drug and you cann abis in the last year. can get up to five years in prison for possessing it and FACT: A small number of 14 years for supplying it. people who use cannabis go on to use other drugs. But most people do not. Want to know more? And don’t forget, for friendly, Use this leaflet to confidential advice and find out about: information, you can call FRANK on 0800 77 66 00 02 cannabis: the basics 24 hours a day. -
Delta-9-Tetrahydrocannabinol and Cannabidiol in Psychosis
medRxiv preprint doi: https://doi.org/10.1101/2021.05.17.21257345; this version posted May 19, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license . Title: Delta-9-tetrahydrocannabinol and cannabidiol in psychosis: A balancing act of the principal phyto-cannabinoids on human brain and behavior? Short title: CBD-THC interaction in psychosis Suhas Ganesh1,2, Jose Cortes-Briones1,2, Ashley M. Schnakenberg Martin1,2, Patrick D Skosnik1,2, Deepak C D’Souza1,2, Mohini Ranganathan*1,2 1 Department of Psychiatry, Yale University School of Medicine 2 VA Connecticut Healthcare System, West Haven, CT 06516 *Corresponding Author Corresponding Author Contact Information: Mohini Ranganathan Associate Professor Department of Psychiatry Yale University School of Medicine VA Connecticut Healthcare System/116A 950 Campbell Ave West Haven, CT 06516 Email: [email protected] Tel: 203-932-5711 X 2546 Fax: 203-937-4860 Word Count: Abstract: 200 Manuscript without online methods: 4463 Figures: main – 3, supplement – 8 Tables: main – 2, supplement – 2 Keywords: delta-9-tetrahydrocannabinol, cannabidiol, psychosis, electrophysiology, neural noise, Lempel-Ziv complexity 1 NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice. medRxiv preprint doi: https://doi.org/10.1101/2021.05.17.21257345; this version posted May 19, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. -
Will Marijuana Legalization Increase Hospitalizations and Emergency Room Visits?
nabi Can s P y o l c i i c l y o P S e s r i i b e a s n n a C WILL MARIJUANA LEGALIZATION INCREASE HOSPITALIZATIONS AND EMERGENCY ROOM VISITS? By Allie Howell July 2018 Since marijuana legalization will likely increase the availability and convenience of consuming marijuana, there is concern that it will also increase health emergencies. An especially prominent concern is that children will be more likely to ingest marijuana in states that have legalized adult use. Reason Foundation WILL MARIJUANA LEGALIZATION INCREASE HOSPITALIZATIONS AND EMERGENCY ROOM VISITS? 2 AVAILABILITY OF EDIBLES MAY INCREASE HOSPITALIZATIONS Traditionally, adult hospitalizations from marijuana use were almost unheard of. Legalization, however, has increased the availability of marijuana products, especially edibles that contain multiple “doses” of delta-9-tetrahydrocannabinol (THC). Edibles have been cited as a common cause for marijuana emergencies because it takes longer to feel the effects of the drug, which may cause users to ingest more. By the time the peak effect of an edible is felt, the user may be extremely high and this may cause them to seek medical attention for acute intoxication.1 MARIJUANA-RELATED EMERGENCIES Edibles have also increased the prevalence of pediatric ingestion because of packaging that makes marijuana products look like candy or desserts. Between 2005 and 2011, there were 985 unintentional pediatric exposures (children nine and younger) in the U.S.2 In Colorado, emergency room visits for teenagers and young adults ages 13–21 increased from 1.8 per 1,000 in 2009 to 4.9 per 1,000 in 2015.3 Another study found that parents at an Aurora, Colorado children's hospital disclosed a history of marijuana exposure in 56% of patients (18 patients) in 2014 and 2015 compared with 19% of patients (three patients) in 2012 and 2013. -
Cannabis: the Good, the Bad & the “Mad” By: Dr
Cannabis: The Good, The Bad & The “Mad” By: Dr. Shahla Modir, M.D. American Board of Psychiatry and Neurology: Addiction Psychiatry & General Psychiatry Question 1 10 How many states have enacted laws to legalize medical marijuana? A. 13 B. 29 C. 32 D. 24 Results 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% 0% 0% 0% 0% A. 13 B. 29 C. 32 D. 24 Question 2 10 What are the following common uses of medical marijuana? A. Spasticity B. Nausea C. Peripheral Neuropathy D. Cachexia E. All of the above Results 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% 0% 0% 0% 0% 0% Spasticity Nausea Peripheral Cachexia All of the Neuropathy above Question 3 10 Medical Marijuana’s 100% safety profile is the 90% 80% same in adolescents 70% as it is in adults? 60% 50% 40% 1. True 30% 2. False 20% 10% 0% 0% 0% True False There are 3 drugs derived from the plant: Cannabis Sativa • Marijuana - refers to leaves/stems (THC 0.5%-5%) & flowers (sinsemilla THC 7- 14%) smoked as reefers, joints, roach, etc. • Hashish - potent resinous substance from dried plant usually smoked in pipes; THC 2%-8% • Hash oil - very potent, viscous liquid extract usually dropped onto normal cigarettes; THC 15%-50% • Plant contains 400 chemicals and over 60 cannabinoids. The smoke contains more than 2000 chemicals. • Delta 9 THC isolated in 1965: is the chemical responsible for producing the psychoactive effect. • Others such as cannabidiol and cannabinol may modify the effects of THC. Delta 9 THC Distribution of Receptor Sites Radiolabeled CP-55,940 CB1 Receptors - 1988 • – Hippocampus – Memory -
Arkansas Medical Marijuana Amendment of 2016
Arkansas Medical Marijuana Amendment of 2016 As revised through 2017 General and First Extraordinary Sessions § 1. Short title. This amendment shall be known and cited as the "Arkansas Medical Marijuana Amendment of 2016". [As added by Const. Amend. 98.] § 2. Definitions. As used in this amendment: (1) "Acquire" or "acquisition" means coming to possess marijuana by means of any legal source herein authorized, not from an unauthorized source, and in accordance with this amendment and any rules promulgated under this amendment; (2) "Assist" or "assisting" means helping a qualifying patient make medical use of marijuana by enabling the medical use by any means authorized under this amendment; (3) "Cardholder" means a qualifying patient, a dispensary agent, a cultivation facility agent, or a designated caregiver; (4) "Cultivation facility" means an entity that: (A) Has been licensed by the Medical Marijuana Commission under § 8 of this amendment; and (B) Cultivates, prepares, manufactures, processes, packages, sells to and delivers usable marijuana to a dispensary; (5) "Cultivation facility agent" means an employee, supervisor, or agent of a cultivation facility who: (A) Is twenty-one (21) years of age or older; (B) Works at the cultivation facility; and (C) Has registered with the Alcoholic Beverage Control Division under § 9 of this amendment; (6) (A) "Designated caregiver" means a person who is at least twenty-one (21) years of age, has not been convicted of an excluded felony offense, has agreed to assist a physically disabled qualifying patient with the medical use of marijuana, and who has registered with the Department of Health under § 5 of this amendment.