PSEN2 Antibody Cat. No.: 29-978

PSEN2 Antibody

Antibody used in WB on rat, mouse brain extract at 1:500 Antibody used in WB on Human Jurkat 0.2-1 ug/ml. (Lane 1: 80ug rat brain extract, Lane 2: 80ug mouse brain extract ).

Specifications

HOST SPECIES: Rabbit

SPECIES REACTIVITY: Dog, Human, Mouse, Rat

Antibody produced in rabbits immunized with a synthetic peptide corresponding a region IMMUNOGEN: of human PSEN2.

TESTED APPLICATIONS: ELISA, IHC, WB

PSEN2 antibody can be used for detection of PSEN2 by ELISA at 1:62500. PSEN2 antibody APPLICATIONS: can be used for detection of PSEN2 by western blot at 1.0 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

POSITIVE CONTROL: 1) Cat. No. 1205 - Jurkat Cell Lysate

PREDICTED MOLECULAR 49 kDa, 50 kDa WEIGHT:

September 26, 2021 1 https://www.prosci-inc.com/psen2-antibody-29-978.html Properties

PURIFICATION: Antibody is purified by peptide affinity chromatography method.

CLONALITY: Polyclonal

CONJUGATE: Unconjugated

PHYSICAL STATE: Liquid

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% BUFFER: sucrose.

CONCENTRATION: batch dependent

For short periods of storage (days) store at 4˚C. For longer periods of storage, store STORAGE CONDITIONS: PSEN2 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.

Additional Info

OFFICIAL SYMBOL: PSEN2

ALTERNATE NAMES: PSEN2, AD3L, AD4, PS2, STM2, CMD1V

ACCESSION NO.: NP_000438

PROTEIN GI NO.: 156105679

GENE ID: 5664

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid- beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes.Alzheimer's disease (AD) patients with an inherited BACKGROUND: form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Two alternative transcripts of PSEN2 have been identified.

REFERENCES: 1) da (2005) Curr Alzheimer Res 2 (5), 507-514.

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