The Potential of Tempeh As a Chemopreventive and Chemotherapeutic Agent Targeting Breast Cancer Cells by Siti Harnina Bintari

Total Page:16

File Type:pdf, Size:1020Kb

The Potential of Tempeh As a Chemopreventive and Chemotherapeutic Agent Targeting Breast Cancer Cells by Siti Harnina Bintari The Potential of Tempeh as a Chemopreventive and Chemotherapeutic Agent Targeting Breast Cancer Cells by Siti Harnina Bintari Submission date: 28-May-2018 11:40AM (UTC+0700) Submission ID: 969395288 File name: 743-749.pdf (1.06M) Word count: 4190 Character count: 21889 The Potential of Tempeh as a Chemopreventive and Chemotherapeutic Agent Targeting Breast Cancer Cells ORIGINALITY REPORT 20% 14% 17% 5% SIMILARITY INDEX INTERNET SOURCES PUBLICATIONS STUDENT PAPERS PRIMARY SOURCES Submitted to King Saud University 1 Student Paper 2% Jonas A. de Araujo, Gina Falavigna, Marcelo 2 % M. Rogero, Ivanir S.O. Pires et al. "Effect of 1 chronic supplementation with branched-chain amino acids on the performance and hepatic and muscle glycogen content in trained rats", Life Sciences, 2006 Publication synapse.koreamed.org 3 Internet Source 1% onlinelibrary.wiley.com 4 Internet Source 1% Batra, V.. "Interaction between cytotoxic 5 % effects of @c-radiation and folate deficiency 1 in relation to choline reserves", Toxicology, 20090108 Publication Submitted to Universitas Riau 6 Student Paper 1% media.proquest.com 7 Internet Source 1% repository.unhas.ac.id 8 Internet Source 1% Zhang, Peng, Zhiyong Guo, Ying Wu, Ronglin 9 % Hu, Jun Du, Xiaoshun He, Xingyuan Jiao, 1 and Xiaofeng Zhu. "Histone Deacetylase Inhibitors Inhibit the Proliferation of Gallbladder Carcinoma Cells by Suppressing AKT/mTOR Signaling", PLoS ONE, 2015. Publication www.pagepress.org 10 Internet Source 1% S H Bintari, S Parman, M Dafip. "The 11 % potential of shark bone powder in breast 1 cancer inhibition (pre-clinical study in DMBA- Induced Sprague Dawly Rats)", Journal of Physics: Conference Series, 2018 Publication jn.nutrition.org 12 Internet Source <1% Chia-Chien Hsieh. "Complementary Roles in 13 % Cancer Prevention: Protease Inhibitor Makes <1 the Cancer Preventive Peptide Lunasin Bioavailable", PLoS ONE, 01/26/2010 Publication Masruri, , Mohamad Farid Rahman, and 14 <1% Bagus Nurkam Ramadhan. "Acidity- controlled selective oxidation of alpha- pinene, isolated from Indonesian pine's turpentine oils (pinus merkusii)", IOP Conference Series Materials Science and Engineering, 2016. Publication dl6.globalstf.org 15 Internet Source <1% www.dovepress.com 16 Internet Source <1% Velentzis, L.S.. "Do phytoestrogens reduce 17 % the risk of breast cancer and breast cancer <1 recurrence? What clinicians need to know", European Journal of Cancer, 200809 Publication www.karger.com 18 Internet Source <1% www.imkerei-kocher.ch 19 Internet Source <1% myctm.org 20 Internet Source <1% Zhaoxia Shen, Dongmei Zhu, Jiao Liu, Juan 21 % Chen, Yun Liu, Chunyan Hu, Zhong Li, Yuan <1 Li. "27-Hydroxycholesterol induces invasion and migration of breast cancer cells by increasing MMP9 and generating EMT through activation of STAT-3", Environmental Toxicology and Pharmacology, 2017 Publication www.slideshare.net 22 Internet Source <1% jnci.oxfordjournals.org 23 Internet Source <1% repository.ung.ac.id 24 Internet Source <1% www.soyconnection.com 25 Internet Source <1% uad.portalgaruda.org 26 Internet Source <1% journals.plos.org 27 Internet Source <1% orca.cf.ac.uk 28 Internet Source <1% Oumi, Y.. "Structural and physico-chemical 29 % properties of high-silica mordenite", <1 Microporous and Mesoporous Materials, 20070419 Publication Elhadi M. Yahia, María Elena Maldonado 30 % Celis, Mette Svendsen. "The Contribution of <1 Fruit and Vegetable Consumption to Human Health", Wiley, 2017 Publication lib.unnes.ac.id 31 Internet Source <1% www.scielo.br 32 Internet Source <1% dare.ubvu.vu.nl 33 Internet Source <1% Salman M. Albeshan, Martin G. Mackey, 34 % Syeda Z. Hossain, Abdulrahman A. Alfuraih, <1 Patrick C. Brennan. "Breast Cancer Epidemiology in Gulf Cooperation Council Countries: A Regional and International Comparison", Clinical Breast Cancer, 2017 Publication Siti Aminah, Suparmo Suparmo, Sri Naruki, 35 % Hastari Wuryastuty. "Consumption of elicited <1 soybean sprout flour increases calcium level in serum of ovariectomized rats", Universa Medicina, 2017 Publication "Lymphatic Vessels as Targets of Tumor 36 % Therapy?", Journal of Experimental <1 Medicine, 09/17/2001 Publication intl-ajpheart.physiology.org 37 Internet Source <1% Ghoncheh, Mahshid, Abdollah 38 % Mohammadian-Hafshejani, and Hamid <1 Salehiniya. "Incidence and Mortality of Breast Cancer and their Relationship to Development in Asia", Asian Pacific Journal of Cancer Prevention, 2015. Publication jco.ascopubs.org 39 Internet Source <1% "Beneficial Microorganisms in Food and 40 % Nutraceuticals", Springer Nature, 2015 <1 Publication www.ncbi.nlm.nih.gov 41 Internet Source <1% Kai, Ting. "The Application of Breast MRI on 42 % Asian Women (Dense Breast Pattern)", <1 Imaging of the Breast - Technical Aspects and Clinical Implication, 2012. Publication www.koreascience.or.kr 43 Internet Source <1% "Abstracts", Journal of Thoracic Oncology, 44 % 2009 <1 Publication Bao, Bin, Asfar S. Azmi, Shadan Ali, Aamir 45 % Ahmad, Yiwei Li, Sanjeev Banerjee, Dejuan <1 Kong, and Fazlul H. Sarkar. "The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness", Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2012. Publication lcr.math.ist.utl.pt 46 Internet Source <1% Methods of Cancer Diagnosis Therapy and 47 % Prognosis, 2010. <1 Publication Mense, Sarah M. Hei, Tom K. Ganju, Rames. 48 % "Phytoestrogens and breast cancer <1 prevention: possible mechanisms of action. (Review)", Environmental Health Perspectives, April 2008 Issue Publication Exclude quotes On Exclude matches Of f Exclude bibliography On.
Recommended publications
  • Effect of Sourdough Fermentation on Lunasin-Like Polypeptides
    Rizzello et al. Microb Cell Fact (2015) 14:168 DOI 10.1186/s12934-015-0358-6 RESEARCH Open Access Italian legumes: effect of sourdough fermentation on lunasin‑like polypeptides Carlo Giuseppe Rizzello1*, Blanca Hernández‑Ledesma2, Samuel Fernández‑Tomé2, José Antonio Curiel1, Daniela Pinto3, Barbara Marzani3, Rossana Coda4 and Marco Gobbetti1 Abstract Background: There is an increasing interest toward the use of legumes in food industry, mainly due to the qual‑ ity of their protein fraction. Many legumes are cultivated and consumed around the world, but few data is available regarding the chemical or technological characteristics, and especially on their suitability to be fermented. Never‑ theless, sourdough fermentation with selected lactic acid bacteria has been recognized as the most efficient tool to improve some nutritional and functional properties. This study investigated the presence of lunasin-like polypeptides in nineteen traditional Italian legumes, exploiting the potential of the fermentation with selected lactic acid bacteria to increase the native concentration. An integrated approach based on chemical, immunological and ex vivo (human adenocarcinoma Caco-2 cell cultures) analyses was used to show the physiological potential of the lunasin-like polypeptides. Results: Italian legume varieties, belonging to Phaseulus vulgaris, Cicer arietinum, Lathyrus sativus, Lens culinaris and Pisum sativum species, were milled and flours were chemically characterized and subjected to sourdough fermenta‑ tion with selected Lactobacillus plantarum C48 and Lactobacillus brevis AM7, expressing different peptidase activities. Extracts from legume doughs (unfermented) and sourdoughs were subjected to western blot analysis, using an anti- lunasin primary antibody. Despite the absence of lunasin, different immunoreactive polypeptide bands were found.
    [Show full text]
  • Soybean Bioactive Peptides and Their Functional Properties
    nutrients Review Soybean Bioactive Peptides and Their Functional Properties Cynthia Chatterjee 1,2, Stephen Gleddie 2 and Chao-Wu Xiao 1,3,* 1 Nutrition Research Division, Food Directorate, Health Products and Food Branch, Health Canada, Banting Research Centre, 251 Sir Frederick Banting Drive, Ottawa, ON K1A 0K9, Canada; [email protected] 2 Ottawa Research & Development Centre, Central Experimental Farm, Agriculture and Agri-Food Canada, 960 Carling Avenue Building#21, Ottawa, ON K1A 0C6, Canada; [email protected] 3 Food and Nutrition Science Program, Department of Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, ON K1S 5B6, Canada * Correspondence: [email protected]; Tel.: +1-613-558-7865; Fax: +1-613-948-8470 Received: 26 July 2018; Accepted: 29 August 2018; Published: 1 September 2018 Abstract: Soy consumption has been associated with many potential health benefits in reducing chronic diseases such as obesity, cardiovascular disease, insulin-resistance/type II diabetes, certain type of cancers, and immune disorders. These physiological functions have been attributed to soy proteins either as intact soy protein or more commonly as functional or bioactive peptides derived from soybean processing. These findings have led to the approval of a health claim in the USA regarding the ability of soy proteins in reducing the risk for coronary heart disease and the acceptance of a health claim in Canada that soy protein can help lower cholesterol levels. Using different approaches, many soy bioactive peptides that have a variety of physiological functions such as hypolipidemic, anti-hypertensive, and anti-cancer properties, and anti-inflammatory, antioxidant, and immunomodulatory effects have been identified.
    [Show full text]
  • Regulation of Intestinal Inflammation by Soybean and Soy-Derived Compounds
    foods Review Regulation of Intestinal Inflammation by Soybean and Soy-Derived Compounds Abigail Raffner Basson 1,2,* , Saleh Ahmed 2, Rawan Almutairi 3, Brian Seo 2 and Fabio Cominelli 1,2 1 Division of Gastroenterology & Liver Diseases, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA; [email protected] 2 Digestive Health Research Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA; [email protected] (S.A.); [email protected] (B.S.) 3 Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA; [email protected] * Correspondence: [email protected] Abstract: Environmental factors, particularly diet, are considered central to the pathogenesis of the inflammatory bowel diseases (IBD), Crohn’s disease and ulcerative colitis. In particular, the Westernization of diet, characterized by high intake of animal protein, saturated fat, and refined carbohydrates, has been shown to contribute to the development and progression of IBD. During the last decade, soybean, as well as soy-derived bioactive compounds (e.g., isoflavones, phytosterols, Bowman-Birk inhibitors) have been increasingly investigated because of their anti-inflammatory properties in animal models of IBD. Herein we provide a scoping review of the most studied disease mechanisms associated with disease induction and progression in IBD rodent models after feeding of either the whole food or a bioactive present in soybean. Keywords: inflammatory bowel disease; isoflavone; bioactive compound; isoflavones; inflammation; Crohn’s disease; western diet; plant-based Citation: Basson, A.R.; Ahmed, S.; Almutairi, R.; Seo, B.; Cominelli, F. Regulation of Intestinal Inflammation by Soybean and Soy-Derived Compounds. Foods 2021, 10, 774.
    [Show full text]
  • The Effect of Lunasin from Indonesian Soybean Extract on Inducible Nitric Oxide Synthase and Β-Catenin Expression in Dextran Sodium Sulfate-Induced Mice Colon
    Online - 2455-3891 Vol 11, Issue 1, 2018 Print - 0974-2441 Research Article THE EFFECT OF LUNASIN FROM INDONESIAN SOYBEAN EXTRACT ON INDUCIBLE NITRIC OXIDE SYNTHASE AND β-CATENIN EXPRESSION IN DEXTRAN SODIUM SULFATE-INDUCED MICE COLON KUSMARDI KUSMARDI1, NESSA NESSA2*, ARI ESTUNINGTYAS2, ARYO TEDJO3, PUSPITA EKA WUYUNG1 1Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Indonesia. 2Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Indonesia. 3Department of Chemical Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia. Email: [email protected] Received: 04 August 2017, Received and Accepted: 23 September 2017 ABSTRACT Objective: Inflammatory bowel diseases are idiopathic inflammatory disorders of the gastrointestinal tract. Chronic inflammation that occurs in the colon can develop into colon cancer. Lunasin has been known to resist inflammatory reactions induced by lipopolysaccharide in vitro. The role of lunasin as anti-inflammatory in vivo is not widely known. In this study, we analyzed the effect of lunasin from Indonesian soybean to decrease the risk Methods:of inflammation A total by of analyzing 30 mice theare expressionsdivided into of six inducible groups. nitricNormal oxide group synthase was not (iNOS) induced and byβ-catenin. dextran sodium sulfate (DSS). The other groups were induced by DSS 2% through drinking water for 9 days. After 9 days, negative group did not receive any treatment, besides the other groups received treatment given lunasin dose 20 mg/kg BB and 40 mg/kg BB, commercial lunasin, and positive given aspirin. Treatment was performed for 5 weeks. Results:Immunohistochemistry scores of iNOS and β-catenin proteins were analyzed using statistical tests.
    [Show full text]
  • Lunasin and Bowman-Birk Protease Inhibitor Concentrations of Protein Extracts from Enzyme- Assisted Aqueous Extraction of Soybeans Juliana Maria L
    Food Science and Human Nutrition Publications Food Science and Human Nutrition 5-31-2011 Lunasin and Bowman-Birk Protease Inhibitor Concentrations of Protein Extracts from Enzyme- Assisted Aqueous Extraction of Soybeans Juliana Maria L. Nobrega de Moura Iowa State University Blanca Hernandez-Ledesma University of California - Berkeley Neiva M. de Almeida Universidade Federal da Paraiba Chia-Chien Hsieh University of California - Berkeley Ben O. de Lumen UFonilvloerwsit ythi of sC andlifor anddia - itBerionkealley works at: http://lib.dr.iastate.edu/fshn_ag_pubs Part of the Agricultural Science Commons, Food Chemistry Commons, and the Plant Biology See next page for additional authors Commons The ompc lete bibliographic information for this item can be found at http://lib.dr.iastate.edu/ fshn_ag_pubs/100. For information on how to cite this item, please visit http://lib.dr.iastate.edu/ howtocite.html. This Article is brought to you for free and open access by the Food Science and Human Nutrition at Iowa State University Digital Repository. It has been accepted for inclusion in Food Science and Human Nutrition Publications by an authorized administrator of Iowa State University Digital Repository. For more information, please contact [email protected]. Lunasin and Bowman-Birk Protease Inhibitor Concentrations of Protein Extracts from Enzyme-Assisted Aqueous Extraction of Soybeans Abstract Lunasin and Bowman-Birk protease inhibitor (BBI) are two soybean peptides to which health-promoting properties have been attributed. Concentrations of these peptides were determined in skim fractions produced by enzyme-assisted aqueous extraction processing (EAEP) of extruded full-fat soybean flakes (an alternative to extracting oil from soybeans with hexane) and compared with similar extracts from hexane- defatted soybean meal.
    [Show full text]
  • (Nutrigenomics) “NTGE 2422” Level II Human Nutrition Mutayomba Sylvestre
    NUTRITIONAL GENOMICS (Nutrigenomics) “NTGE 2422” Level II Human nutrition Mutayomba Sylvestre Nutritional Genomics for Human Nutrition 6/18/2019 1 Level II (CUR) SUBJECT UNIT 1. Genetics variability 2. Nutrition and gene Nutritional Genomics for Human Nutrition 6/18/2019 2 Level II (CUR) GROUP ASSIGNMENTS 1. Preventive medicine and personalized diet 2. Metabolic syndrome 3. Genetics influence on cancer prevention. 4. Environmental influence on cancer prevention. Nutritional Genomics for Human Nutrition 6/18/2019 3 Level II (CUR) INTRODUCTION The link between food and health is a long and a well documented one. With over 24,000 people worldwide dying from hunger each day and obesity reaching epidemic proportions in developed counties, the consequences of too little or too much food are easily seen. People no longer view food as merely a source of calories but rather as a complex mixture of dietary chemicals, some of which are capable of preventing, mitigating, or treating disease. With the sequencing of the human genome, a new genetic dimension has been added to the equation linking the foods we eat to the good health we all hope to enjoy. We bring two things to the dinner table: our appetite and our genotype. Nutritional Genomics for Human Nutrition 6/18/2019 4 Level II (CUR) Genetic diversity makes each of us uniquely different, we are also beginning to understand why we respond to our nutritional environment differently and how these differences can, over time, lead to health or disease. Genomic analysis reveals that humans are 99.9% identical at the DNA level. This implies that the remaining 0.1% of the human genome (or about three million single nucleotide polymorphisms (SNPs)) is responsible for all the morphological, physiological, biochemical and molecular differences between any two individuals.
    [Show full text]
  • Regulation of Cholesterol Metabolism by Bioactive Components of Soy Proteins: Novel Translational Evidence
    International Journal of Molecular Sciences Review Regulation of Cholesterol Metabolism by Bioactive Components of Soy Proteins: Novel Translational Evidence Giusy Rita Caponio 1,2, David Q.-H. Wang 3 , Agostino Di Ciaula 2 , Maria De Angelis 1,* and Piero Portincasa 2,* 1 Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro, via Amendola 165/a, 70126 Bari, Italy; [email protected] 2 Division of Internal Medicine Clinica Medica “A. Murri”, Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, 70124 Bari, Italy; [email protected] 3 Department of Medicine and Genetics, Division of Gastroenterology and Liver Diseases, Marion Bessin Liver Research Center, Einstein-Mount Sinai Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA; [email protected] * Correspondence: [email protected] (M.D.A.); [email protected] (P.P.); Tel.: +39-080-5442949 (M.D.A.); +39-080-5478893 (P.P.) Abstract: Hypercholesterolemia represents one key pathophysiological factor predisposing to in- creasing risk of developing cardiovascular disease worldwide. Controlling plasma cholesterol levels and other metabolic risk factors is of paramount importance to prevent the overall burden of disease emerging from cardiovascular-disease-related morbidity and mortality. Dietary cholesterol under- goes micellization and absorption in the small intestine, transport via blood, and uptake in the liver. An important amount of cholesterol originates from hepatic synthesis, and is secreted by the liver into bile together with bile acids (BA) and phospholipids, with all forming micelles and vesicles. In clinical medicine, dietary recommendations play a key role together with pharmacological interventions to counteract the adverse effects of chronic hypercholesterolemia.
    [Show full text]
  • Analysis of Soybean Protein-Derived Peptides and the Effect of Cultivar, Environmental Conditions, and Processing on Lunasin Concentration in Soybean and Soy Products
    936 WANG ET AL.: JOURNAl. OF AOAC INTERNATIONAL VOL. 91, No. 4, 2008 SPECIAL GUEST EDITOR SECTION Analysis of Soybean Protein-Derived Peptides and the Effect of Cultivar, Environmental Conditions, and Processing on Lunasin Concentration in Soybean and Soy Products WENYI WANG, VERMONT P. DIA, MIGUEL VASCONF:Z, and ELVIRA GONZALEZ 1W MEJIA1 University of Illinois, Department of Food Science and Human Nutrition, 228 ERML, 1201 W. Gregory Dr, Urbana, IL 61801 RANDALL L NELSON U.S. Department of Agriculture, Agricultural Research Service, Soybean/Maize Gerrnplasm, Pathology, and Genetics Research Unit, Department of Crop Sciences, 1101 W. Peabody Dr. University of Illinois, Urbana, IL 61801 Soybean, an important source of food proteins, has quantified by using different techniques and received increasing interest from the public conditions. In addition, lunasin concentration in because of its reported health benefits. These health soybean depends mainly on cultivar and to some benefits are attributed to its components, including extent on environmental factors, particularly isoflavones, saponins, proteins, and peptides. temperature. Lunasin concentration in soy products Lunasin, Bowman-Birk inhibitor, lectin, and was also affected by processing conditions. 3-conglycinin are some of the biologically active peptides and proteins found in soybean. This article provides a comprehensive review on the recently ood proteins have long been recognized as a source of used techniques in the analysis and essential amino acids required for the maintenance of characterization of food bioactive peptides, with F life. They also serve certain functions as ingredients in emphasis on soybean peptides. The methods used foods and food preparations. For the past 2 to 3 decades, to isolate and purify lunasin from defatted soybean attention has been given to other aspects of food proteins, flour were ion-exchange chromatography, such as their biologically active peptides derived either from ultrafiltration, and gel filtration chromatography.
    [Show full text]
  • Environmental and Genetic Variation of the Anti-Cancer Peptides Lunasin and Bowman-Birk Protease Inhibitor in Glycine Max
    ENVIRONMENTAL AND GENETIC VARIATION OF THE ANTI-CANCER PEPTIDES LUNASIN AND BOWMAN-BIRK PROTEASE INHIBITOR IN GLYCINE MAX BY DANIEL WILLIAM WALTON THESIS Submitted in partial fulfillment of the requirements for the degree of Master of Science in Crop Sciences in the Graduate College of the University of Illinois at Urbana-Champaign, 2013 Urbana, Illinois Adviser: Professor Randall L. Nelson ii ABSTRACT The economic importance of soybean (Glycine max) as a foodstuff has, in recent years, been supplemented by its importance as a source of bioactive compounds. Two of these compounds, the Bowman-Birk protease inhibitor (BBI) and the peptide lunasin, exhibit anti- cancer properties, and clinical studies suggest that the two may act in a complementary fashion. The present work surveys the levels of these two compounds across a time course of soybean development, a number of diverse soybean genotypes from the USDA Soybean Germplasm Collection, and a collection of soybean lines grown at Urbana and Bellflower, IL in the summer of 2012. Concentrations of BBI measured across mature lines in the study ranged from .101 to .38 mg/g defatted seed, while concentrations of lunasin ranged from 1.06 to 6.12 mg/g defatted seed. BBI and lunasin were significantly correlated through seed development (p = .0097), but concentrations of the compounds were not related in mature seeds. Genotype and the interaction of genotype by environment were found to significantly impact BBI (p = .03; p = .01), and this interaction effect was found to vary in direction depending on genotype. Environment (p = .03) and genotype had significant effects (p = .03; p < .01) on lunasin.
    [Show full text]
  • Lunasin As a Promising Health-Beneficial Peptide
    Eur opean Rev iew for Med ical and Pharmacol ogical Sci ences 2014; 18: 2070-2075 Lunasin as a promising health-beneficial peptide J. LIU 1, S.-H. JIA 1, M. KIRBERGER 2, N. CHEN 1 1College of Health Science, Wuhan Sports University, Wuhan, China 2Department of Natural Sciences, Clayton State University, Morrow, GA, USA Jun Liu and Shaohui Jia contributed equally to this work Abstract. – Lunasin, a 43 amino acid characterized as a small polypeptide with poly- polypeptide originally isolated from soybean, is known to produce multiple health benefits, in - Asp (D) residues located at the carboxyl termi - cluding anti-hypertension, antioxidant activity, nus , and was subsequently found in other beans, cancer prevention or therapy, anti-inflamma - grains and herbal plants , including wheat, barley, tion, hypocholesterolemic activity, anti-obesity rye, sunberry, wonderberry, bladder-cherry , jim - and immunomodulation. These effects are be - son weed , Solanum nigrum L ., amaranth and trit - lieved to be due to its unique structure that in - icale , at concentrations ranging from 0.013 to cludes a putative helical region, an Arg-Gly-Asp 4 (RGD) motif and an Asp-rich carboxyl terminus. 70.5 mg protein lunasin/g of protein (Table I ) . The focus of this article is to summarize the Since then, lunasin has been the subject of sever - discovery, characterization and biological activ - al investigations, including a very important ities of lunasin, which will provide a reference study on the cloning of the soybean lunasin gene for the future development and utilization of lu - and subsequent transfection into mammalian nasin, and a basis for exploring the underlying mechanisms of these health-beneficial func - cells, at the California University at Berkeley tions.
    [Show full text]
  • Chemopreventive and Therapeutic Properties of Peptide Lunasin
    1 Updating the research on the chemopreventive and therapeutic role of 2 peptide lunasin 3 Running title: Chemopreventive and therapeutic properties of peptide lunasin 4 Chia-Chien Hsieh1, Cristina Martínez-Villaluenga2, Ben O. de Lumen3, Blanca Hernández- 5 Ledesma4* 6 7 1 Department of Human Development and Family Studies (Nutritional Science & Education), 8 National Taiwan Normal University, No. 162, Heping East Road, Section 1, Taipei 10610, 9 Taiwan 10 2 Institute of Food Science, Technology and Nutrition (ICTAN-CSIC), Juan de la Cierva 3, 11 28006 Madrid 12 3 Department of Nutritional Science and Toxicology, University of California at Berkeley, 13 119 Morgan Hall, Berkeley, CA 94720-3104, USA 14 4 Instituto de Investigación en Ciencias de la Alimentación (CIAL, CSIC-UAM, CEI 15 UAM+CSIC). Nicolás Cabrera, 9. 28049 Madrid, Spain 16 17 * Corresponding author: B. Hernández-Ledesma 18 Nicolás Cabrera, 9. 28049 Madrid, Spain 19 Phone: +34 910017970 20 Fax: +34 910017905 21 e-mail: [email protected] 22 1 23 Abstract 24 Chronic diseases have become the medical challenge of the 21st century because of their high 25 incidence and mortality rates. Modulation of diet and lifestyle habits is considered as the best 26 strategy for the prevention of these disorders. Health promoting benefits beyond their 27 nutritional effects have been described for multiple dietary compounds. Among these 28 compounds, peptide lunasin is considered as one of the most promising. Naturally present in 29 soybean, lunasin has been extensively studied in the last two decades because of its potential 30 against chronic diseases, such as cancer, cardiovascular and immunological disorders.
    [Show full text]
  • Soy, Soy Foods and Their Role in Vegetarian Diets
    nutrients Review Soy, Soy Foods and Their Role in Vegetarian Diets Gianluca Rizzo 1,* ID and Luciana Baroni 2 1 Via Venezuela 66, 98121 Messina, Italy 2 Primary Care Unit, Northern District, Local Health Unit 2, 31100 Treviso, Italy; [email protected] * Correspondence: [email protected]; Tel.: +39-320-897-6687 Received: 8 November 2017; Accepted: 3 January 2018; Published: 5 January 2018 Abstract: Soy is a basic food ingredient of traditional Asian cuisine used for thousands of years. In Western countries, soybeans have been introduced about a hundred years ago and recently they are mainly used for surrogate foods production. Soy and soy foods are common nutritional solutions for vegetarians, due to their high protein content and versatility in the production of meat analogues and milk substitutes. However, there are some doubts about the potential effects on health, such as the effectiveness on cardiovascular risk reduction or, conversely, on the possible disruption of thyroid function and sexual hormones. The soy components that have stimulated the most research interest are isoflavones, which are polyphenols with estrogenic properties highly contained in soybeans. In this review, we discuss the characteristics of soy and soy foods, focusing on their nutrient content, including phytoestrogens and other bioactive substances that are noteworthy for vegetarians, the largest soy consumers in the Western countries. The safety of use will also be discussed, given the growing trend in adoption of vegetarian styles and the new soy-based foods availability. Keywords: soy foods; vegetarian diets; phytoestrogens; isoflavones; protein quality; meat analogues; thyroid health; endocrine disruptor; selective oestrogen receptor modulator; cancer 1.
    [Show full text]