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CURRICULUM VITAE Xinggang Liu, M.D. Doctoral Candidate

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CURRICULUM VITAE Xinggang Liu, M.D. Doctoral Candidate Determinants of Intrathoracic Adipose Tissue Volume and its Association with Cardiovascular Disease Risk Factors Item Type dissertation Authors Liu, Xinggang Publication Date 2012 Abstract Background: The volume of intrathoracic fat has been associated in some studies with cardiovascular diseases risk factors. To further assess the role of intrathoracic fat in coronary atherosclerosis risk, we measured the volume of intrathoracic fat i... Keywords intrathoracic adipose tissue; Cardiovascular Diseases; Genome- Wide Association Study; Obesity Download date 28/09/2021 02:45:03 Link to Item http://hdl.handle.net/10713/1666 CURRICULUM VITAE Xinggang Liu, M.D. Doctoral Candidate, Department of Epidemiology and Public Health University of Maryland School of Medicine CONTACT INFORMATION Epidemiology and Human Genetics Program School of Medicine University of Maryland, Baltimore 660 West Redwood St., Howard Hall 140C Baltimore, MD 21202 Phone: 14109005003 Email: [email protected] EDUCATION 2006–2012 Ph.D. in Epidemiology (expected) Epidemiology and human Genetics Program, School of Medicine, University of Maryland, Baltimore, MD 1999–2004 M.D. West China Medical Center, Sichuan University, Chengdu, Sichuan, China POSTGRADUATE TRAINING 2004–2006 Thoracic Surgical Resident Department of Thoracic Surgery, West China Hospital REASERCH TRAINING 2006–2012 Graduate Research Assistant Department of Epidemiology and Preventive Medicine, University of Maryland, Baltimore, MD TEACHING SERVICE 2010 Teaching Assistant Clinical Trials and Experimental Design, Department of Epidemiology and Preventive Medicine, University of Maryland, Baltimore 2007 Teaching Assistant Principles of Biostatistics, Department of Epidemiology and Preventive Medicine, University of Maryland, Baltimore REASERCH EXPERIENCES Genetic Epidemiology Formal training and dissertation in genetic epidemiology Quantitative analysis for complex traits Linkage analysis Genome-wide Association Study Construction of predictive genetic scores Lab experiences Genotyping and fine sequencing of candidate genes Healthcare Administrative Data and Analysis Creation and maintenance of relational dataset compiled from multiple sources, including hospital administrative and billing data, and blood bank data Ability to assess data for accuracy and completeness, model validation Facility in using ICD9-CM coding in adjustment and analysis Statistical skills including multiple imputation, time-trend analysis, longitudinal data analysis, generalized linear models, logistical regression models These skills resulted in multiple publications, including the highest impact journal dedicated to critical care Survey Design and Interpretation Experience in multiple studies utilizing validated survey instruments Able to assess survey completion and assemble databases Able to utilize extensive statistical analysis, including regressions, Pearson coefficients, Cronbach alpha, multiple imputations These skills were pivotal in completion of two survey studies with a combined sample size of nearly 6,000 subjects These studies have resulted in peer reviewed publication, an abstract presented at an international meeting, and a manuscript in requested revision Monte Carlo and Markov Models Experience in constructing Monte Carlo and Markov Models Determination of Minimal Clinical Important Differences in target patient population This work resulted in poster presentation at the Society for Clinical Trials annual meeting HONORS AND AWARDS 2006 Merit Students Scholarship, University of Maryland, Baltimore PUBLICATIONS Peer Reviewed Journal Articles 1. Transfusion practice in the intensive care unit: a 10 year analysis. Netzer G, Liu X, Harris AD, Edelman BB, Hess JR, Shanholtz C, Murphy DJ, Terrin ML. Transfusion. 2010; 50(10):212534. PMID: 20553436. 2. Gingival carcinoma: retrospective analysis of 72 patients and indications for elective neck dissection. Lubek J, ElHakim M, Salama AR, Liu X, Ord RA. Br J Oral Maxillofac Surg. 2010 May 10. PMID: 20462676. 3. Decreased mortality resulting from a multicomponent intervention in a tertiary care medical intensive care unit. Netzer G, Liu X, Shanholtz C, Harris A, Verceles A, Iwashyna TJ. Crit Care Med. 2011;39(2):28493. PMID: 21076286. 4. Pregnancy among Women Surgeons: Trends over Time. Turner PL, Lumpkins K, Gabre J, Lin MJ, Liu X, Terrin M.Arch Surg. 2012 Feb 20. PMID:22351877 5. Ambient Light Levels and Critical Care Outcomes. Verceles AC, Liu X, Terrin ML, Scharf SM, Shanholtz C, Harris A, Ayanleye B, Parker A, Netzer G. Journal of Critical Care. In press. Manuscripts under review/revision 1. Respiratory Therapy Organizational Changes are Associated with Improved Best Practice. Parker AM, Liu X, Harris A, Shanholtz C, Smith RL, Hess DR, Reynolds M, Netzer G. In requested revision. 2. Learned Helplessness Among Families and Loved Ones of the Critically Ill. Sullivan DR, Liu X, Corwin D, Verceles AC, McCurdy M, Titus J, Netzer G. In requested revision. Abstracts and conference presentations 1. Gingival carcinoma retrospective analysis of 74 patients. Lubek J, ElHakim M, Salama AR, Liu X, Ord RA. British Journal of Oral and Maxillofacial Surgery 46 (2008) e32–e67 2. Transfusion Practice in the Intensive Care Unit: A Ten-Year Analysis. Netzer G, Liu X, Harris A, Edelman B, Hess J, Shanholtz C, Murphy DJ, Terrin ML. Annual Meeting of the American Society of Hematology, 2009 3. Substantial Changes in Several Outcomes with a Multi-Component Intervention in a Tertiary Care Medical Intensive Care Unit. Netzer G, Liu X, Terrin ML, Shanholtz C, Harris AD, Verceles A, Iwashyna TJ. American Thoracic Society Scientific Session, 2010 4. Effect of a Multicomponent Intervention on Sedation Use. Netzer G, Liu X, Terrin ML, Shanholtz C, Harris AD, Verceles A, Iwashyna TJ. American Thoracic Society Scientific Session, 2010 5. Relationship between Ambient Light Levels and MICU Outcomes. Verceles, A, Liu X, Shanholtz C, Scharf SM, Harris AD, Ayanleye B, Netzer G. American Thoracic Society Scientific Session, 2010 6. Respiratory Therapy Organization Changes Result in Increased Respiratory Care Resource Utilization in a Tertiary Care Medical Intensive Care Unit. Parker A, Liu X, Harris AD, Smith R, Reynolds M, Shanholtz C, Netzer G. Chest October 2010 vol 138 No.4 Supp 766A 7. Variation in Stress Dose Steroid Use in Patients with Severe Sepsis in a Medical Intensive Care Unit. Paul TK, Liu X, Swanson EC, Gonzales JP, Netzer G. Chest.10521 October 2010 vol 138 No.4 Supp 390A Abstract Determinants of Intrathoracic Adipose Tissue Volume and its Association with Cardiovascular Disease Risk Factors Xinggang Liu, Doctor of Philosophy, 2012 Dissertation Directed by: Braxton D. Mitchell, PhD, MPH Professor Epidemiology and Public Health Background: The volume of intrathoracic fat has been associated in some studies with cardiovascular diseases risk factors. To further assess the role of intrathoracic fat in coronary atherosclerosis risk, we measured the volume of intrathoracic fat in 910 relatively healthy Amish adults from Lancaster County, PA, and assessed correlations of intrathoracic fat volume and its two subcomponents with cardiovascular risk factors and coronary artery calcification (CAC). Further we also explored the heritability and genetic determinants of intrathoracic fat volume. Methods and results: Intrathoracic fat, epicardial and pericardial fat volume were measured from EBCT scans (3-mm thickness) obtained from the right pulmonary artery to the diaphragm. There was high correlation between epicardial, pericardial and intrathoracic fat volume. Similar findings were observed while examine intrathoracic, epicardial and pericardial fat volume. Epicardial fat volume was significantly correlated with older age (p<0.001), male gender (p<0.01), and increasing BMI (p<0.001). Multivariate regression model was used to evaluate the correlation between epicardial fat volume and cardiovascular disease risk factors while adjusting for age, gender, family structure and BMI. Epicardial fat volume was associated with higher systolic (p<0.01) and diastolic (p=0.04) blood pressure, higher pulse pressure (p=0.02), higher levels of fasting glucose, insulin, triglycerides (p<0.001) and total cholesterol (p=0.05). After adjusting for BMI or waist circumference, the above associations were diminished and no longer statistically significant. Neither coronary calcification score nor coronary calcification presence (coronary calcification score>0) was associated with increased epicardial fat volume after adjusting for age and gender. Similar associations were found examining pericardial and intrathoracic fat volume. Genetic analysis revealed that intrathoracic fat shares both environmental and genetic determinants with other obesity traits. Our genome wide association analysis and targeted SNPs analysis identified several candidate SNPs/genes which might be specifically associated with this regional fat deposit. Conclusions: We conclude that intrathoracic fat volume is significantly correlated with adverse cardiovascular risk factors (although not with increased CAC) in age and gender adjusted models. However, the associations were not independent of BMI. Intrathoracic fat volume closely correlates with various obesity measurements, except liver fat, by sharing both similar environmental and genetic influences. Determinants of Intrathoracic Adipose Tissue Volume and its Association with Cardiovascular Disease Risk Factors By Xinggang Liu Dissertation submitted to the Faculty of the
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