Oral Versus Intramuscular Administration of Vitamin B12 for Vitamin B12 Deficiency in Primary Care: a Pragmatic, Randomised, Non-Inferiority Clinical Trial (OB12)
Open access Original research BMJ Open: first published as 10.1136/bmjopen-2019-033687 on 20 August 2020. Downloaded from Oral versus intramuscular administration of vitamin B12 for vitamin B12 deficiency in primary care: a pragmatic, randomised, non- inferiority clinical trial (OB12) Teresa Sanz- Cuesta ,1,2 Esperanza Escortell- Mayor,1,2 Isabel Cura- Gonzalez ,1,2,3 Jesus Martin- Fernandez,2,3,4 Rosario Riesgo- Fuertes,2,5 Sofía Garrido- Elustondo,2,6 Jose Enrique Mariño- Suárez,7 Mar Álvarez- Villalba,2,8 Tomás Gómez- Gascón,2,9 Inmaculada González- García,10 Paloma González- Escobar,11 Concepción Vargas- Machuca Cabañero,12 Mar Noguerol-Álvarez,13 Francisca García de Blas- González,2,14 Raquel Baños- Morras,11 Concepción Díaz- Laso,15 Nuria Caballero- Ramírez,16 Alicia Herrero de- Dios,17 Rosa Fernández- García,18 Jesús Herrero- Hernández,19 Belen Pose- García,14 20 20 20 To cite: Sanz- Cuesta T, María Luisa Sevillano- Palmero, Carmen Mateo- Ruiz, Beatriz Medina- Bustillo, 21 Escortell- Mayor E, Cura- Monica Aguilar- Jiménez, and OB12 Group Gonzalez I, et al. Oral versus intramuscular administration of vitamin B12 for vitamin B12 deficiency in primary care: ABSTRACT a pragmatic, randomised, Strengths and limitations of this study non- inferiority clinical Objectives To compare the effectiveness of oral versus trial (OB12). BMJ Open intramuscular (IM) vitamin B (VB12) in patients aged ≥65 12 ► This is the largest and longest follow-up randomised 2020; :e033687. doi:10.1136/ years with VB12 deficiency. 10 clinical trial in patients aged ≥65 years with VB12 bmjopen-2019-033687 Design Pragmatic, randomised, non- inferiority, deficiency.
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