PBX3 PBX3 PBX3 PBX3 PBX3 PBX3 PBX3 PBX3 PBX3

SP1 FOS FOS SP1 FOS SP1 SP1FOS FOS SP1 SP1FOS SP1FOS FOSSP1 FOSSP1 NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 NRF1PBX3 PBX3 NRF1 NRF1PBX3 NRF1 PBX3 NRF1 PBX3 PBX3 NRF1 NRF1 PBX3 PBX3NRF1 PBX3 NRF1 EGR1 SP1 SP1 EGR1 EGR1 SP1 EGR1SP1 EGR1 SP1 SP1EGR1 EGR1SP1 SP1EGR1 EGR1SP1 EBF1inputRFX5 RFX5EBF1input inputRFX5EBF1 inputRFX5 EBF1 EBF1inputRFX5 EBF1 inputRFX5 RFX5inputEBF1 EBF1RFX5input RFX5EBF1input EGR1input IRF3 FOSFOS IRF3 inputEGR1 inputFOSEGR1 IRF3 inputIRF3FOSEGR1 inputEGR1FOSIRF3 FOSinputIRF3EGR1 inputEGR1IRF3FOS IRF3inputFOSEGR1 EGR1IRF3FOS input EBF1PAX5PAX5SRFSTAT1 FOS FOS PAX5STAT1EBF1SRF SRFFOSPAX5STAT1PAX5EBF1 STAT1SRFFOSPAX5PAX5 EBF1 PAX5STAT1EBF1SRFFOS EBF1 FOSSTAT1PAX5PAX5SRF PAX5PAX5STAT1SRFFOSEBF1 EBF1SRFFOSPAX5STAT1 FOSSTAT1PAX5PAX5SRFEBF1 TCF3 BHLHE40SRFMAXinputRFX5 RFX5inputBHLHE40MAXTCF3SRF BHLHE40TCF3MAXSRF RFX5input RFX5SRFinputMAXTCF3BHLHE40 BHLHE40MAXinputTCF3RFX5SRF TCF3 RFX5inputSRFMAXBHLHE40 RFX5BHLHE40inputTCF3MAXSRF SRFBHLHE40RFX5MAXTCF3input BHLHE40RFX5TCF3MAXSRFinput TCF12BCL3PAX5PAX5ZEB1MXI1MAX USF1IRF3 IRF3 MXI1TCF12BCL3MXI1PAX5MAXPAX5ZEB1USF1 USF1 MAXTCF12MXI1MXI1BCL3ZEB1PAX5PAX5IRF3 MXI1IRF3ZEB1TCF12MAXPAX5PAX5BCL3 USF1 USF1 MAXMXI1MXI1TCF12BCL3PAX5ZEB1PAX5 IRF3 TCF12IRF3BCL3PAX5PAX5ZEB1MAXMXI1MXI1USF1 BCL3PAX5MXI1TCF12MAXZEB1IRF3USF1 IRF3USF1MXI1TCF12MAXMXI1PAX5BCL3PAX5ZEB1 USF1TCF12BCL3IRF3MAXZEB1MXI1MXI1PAX5PAX5 LV1 BCL11APOU2F2TCF12MEF2CEGR1STAT1inputUSF2 POU2F2BCL11AinputSTAT1MEF2CUSF2TCF12EGR1 USF2EGR1POU2F2TCF12MEF2CinputSTAT1BCL11A POU2F2inputSTAT1EGR1MEF2CBCL11ATCF12USF2 USF2 BCL11APOU2F2TCF12STAT1MEF2CinputEGR1 POU2F2TCF12BCL11ASTAT1inputMEF2CEGR1USF2 inputPOU2F2MEF2CSTAT1BCL11ATCF12EGR1USF2 EGR1POU2F2USF2BCL11ASTAT1TCF12MEF2Cinput USF2POU2F2MEF2CBCL11ATCF12STAT1EGR1input BCL11APOU2F2EBF1SRFELF1 ZNF143 POU2F2EBF1BCL11ASRFELF1ZNF143 ELF1POU2F2BCL11ASRF EBF1ZNF143 ZNF143ELF1 POU2F2SRFBCL11A EBF1 ZNF143BCL11APOU2F2EBF1 ELF1SRF ZNF143EBF1 POU2F2BCL11ASRFELF1 ZNF143POU2F2BCL11ASRFELF1EBF1 ELF1EBF1SRFPOU2F2BCL11AZNF143 ZNF143POU2F2SRFBCL11AELF1EBF1 32% of variance TCF3NFATC1STAT5ARUNX3MEF2ASPI1RUNX3ATF2BHLHE40EBF1ELF1 ATF3ZNF143 EBF1NFATC1BHLHE40STAT5AATF2SPI1RUNX3RUNX3TCF3MEF2AELF1ATF3 ZNF143 ATF3BHLHE40TCF3ELF1NFATC1STAT5AMEF2AATF2RUNX3RUNX3SPI1EBF1ZNF143 ZNF143ELF1 STAT5ASPI1NFATC1MEF2AATF2RUNX3TCF3ATF3RUNX3BHLHE40EBF1 ATF3 BHLHE40ZNF143NFATC1STAT5ARUNX3EBF1TCF3ATF2SPI1MEF2AELF1 ZNF143EBF1TCF3NFATC1STAT5ARUNX3RUNX3MEF2AATF2BHLHE40ELF1ATF3SPI1 ZNF143MEF2AATF3NFATC1BHLHE40SPI1ATF2ELF1TCF3STAT5ARUNX3RUNX3EBF1 SPI1ELF1EBF1BHLHE40NFATC1STAT5ARUNX3RUNX3TCF3ATF2ATF3MEF2AZNF143 ZNF143BHLHE40TCF3MEF2ASTAT5ANFATC1ATF3RUNX3ATF2ELF1EBF1SPI1 BCL3PMLZBTB33NFATC1MTA3MEF2CYY1ZEB1 USF1 ZBTB33NFATC1MTA3PMLPMLBCL3MEF2CYY1USF1ZEB1 USF1 ZEB1MEF2CPMLBCL3ZBTB33PMLNFATC1YY1YY1MTA3 YY1 ZBTB33PMLNFATC1MTA3MEF2CZEB1BCL3 USF1 USF1 NFATC1MTA3ZBTB33YY1PMLBCL3MEF2CZEB1 ZBTB33PMLNFATC1MTA3BCL3MEF2CYY1YY1ZEB1 USF1 ZBTB33NFATC1MEF2CPMLPMLBCL3MTA3ZEB1USF1 YY1YY1 USF1NFATC1PMLPMLMTA3BCL3MEF2CZBTB33ZEB1 YY1 YY1 MEF2CUSF1PMLPMLNFATC1BCL3MTA3ZEB1ZBTB33 POU2F2MTA3BATFMEF2AATF2SRF NFE2USF2ATF3 POU2F2ATF2USF2NFE2MTA3BATFMEF2ASRFATF3 ATF3USF2NFE2POU2F2MEF2ASRFMTA3BATFATF2 POU2F2SRFMTA3ATF2MEF2AATF3BATFNFE2USF2 USF2ATF3NFE2 POU2F2MTA3BATFATF2MEF2ASRF POU2F2MTA3MEF2AATF2BATFSRFUSF2NFE2ATF3 ATF3POU2F2MEF2AATF2BATFMTA3SRFNFE2USF2 USF2POU2F2SRFMTA3ATF2BATFATF3NFE2MEF2A POU2F2NFE2USF2MEF2ASRFATF2ATF3MTA3BATF STAT5ABCLAF1ZBTB33SPI1IRF4RXRAETS1STAT3ETS1 ZBTB33STAT3SPI1STAT5AIRF4RXRABCLAF1ETS1 RXRASTAT5ABCLAF1ZBTB33ETS1IRF4STAT3SPI1ETS1 ETS1ETS1ZBTB33BCLAF1SPI1STAT5ASTAT3RXRAIRF4 ZBTB33STAT3STAT5AETS1BCLAF1IRF4ETS1SPI1RXRA ZBTB33STAT5ABCLAF1ETS1ETS1STAT3RXRAIRF4 SPI1 ZBTB33RXRASPI1STAT3BCLAF1IRF4STAT5AETS1ETS1 SPI1 ETS1STAT5ABCLAF1ETS1STAT3IRF4ZBTB33RXRA STAT5ABCLAF1RXRAETS1ETS1STAT3IRF4SPI1ZBTB33 IRF4RXRA IRF4RXRA RXRAIRF4 RXRAIRF4 IRF4RXRA RXRAIRF4 RXRAIRF4 IRF4RXRA RXRA IRF4 SPI1BCLAF1JUNDGABPAinputinputinput JUNDinputinputinputSPI1BCLAF1GABPA GABPAinputBCLAF1inputSPI1input JUNDGABPA inputBCLAF1inputinputSPI1JUND inputJUNDinputinputBCLAF1SPI1 GABPA BCLAF1inputinput inputGABPASPI1JUND JUND input SPI1BCLAF1inputinput GABPA GABPA SPI1 JUNDBCLAF1inputinputinput JUNDBCLAF1SPI1inputGABPAinputinput GABPAinput NFE2SIX5 NFE2input GABPASIX5 NFE2GABPA input SIX5 GABPASIX5 input NFE2 NFE2 inputSIX5 GABPA SIX5input NFE2GABPA inputSIX5NFE2GABPA GABPA NFE2inputSIX5 NFE2SIX5 GABPAinput BATFSTAT3JUND SIX5 JUNDBATFSTAT3 SIX5 STAT3BATFSIX5JUNDSIX5 STAT3JUNDBATF BATFSTAT3JUNDSIX5 SIX5STAT3BATF JUND JUND BATFSTAT3SIX5 JUNDBATFSTAT3SIX5 JUND STAT3SIX5BATF

input input input input input input input input input FOS FOS FOS FOS FOS FOS FOS FOS FOS FOS FOS FOS FOS FOS FOS FOS FOS FOS FOS FOS FOS FOS FOS FOS FOS FOS FOS

ZNF143ZNF143 ZNF143ZNF143 ZNF143 ZNF143ZNF143 ZNF143ZNF143 ZNF143ZNF143 ZNF143ZNF143 ZNF143ZNF143 ZNF143 SIX5 ATF3 IRF3IRF3 IRF3IRF3 ATF3SIX5 ATF3 IRF3IRF3 SIX5 SIX5 IRF3IRF3ATF3 ATF3 SIX5 IRF3IRF3 IRF3IRF3SIX5 ATF3 ATF3 IRF3IRF3SIX5 IRF3IRF3ATF3SIX5 IRF3ATF3IRF3SIX5 SIX5USF2USF1 USF2 USF1SIX5 USF1 USF2 SIX5 SIX5 USF2USF1 USF2USF1 SIX5 SIX5 USF2USF1 USF2USF1SIX5 USF2USF1SIX5 USF2USF1SIX5 NFE2 SP1PBX3 PBX3SP1NFE2 NFE2 PBX3SP1 SP1NFE2PBX3 NFE2 SP1PBX3 PBX3 SP1 NFE2 SP1NFE2PBX3 PBX3NFE2SP1 NFE2SP1PBX3 NFE2 USF1ATF3USF2 SP1 LV2 SP1NFE2 USF2USF1ATF3 USF1USF2ATF3NFE2 SP1 ATF3SP1NFE2USF2USF1 NFE2USF1USF2ATF3 SP1 SP1 USF2USF1NFE2ATF3 ATF3SP1USF2NFE2USF1 NFE2USF1USF2SP1ATF3 USF2USF1ATF3SP1NFE2 PBX3 7% of variance PBX3 PBX3 PBX3 PBX3 PBX3 PBX3 PBX3 PBX3 RFX5NRF1 RFX5 NRF1 NRF1 RFX5 NRF1RFX5 NRF1RFX5 NRF1RFX5 NRF1 RFX5 RFX5 NRF1 RFX5 NRF1 input input RFX5NRF1 inputRFX5inputNRF1 NRF1 RFX5input input NRF1inputinputRFX5 NRF1input inputRFX5 NRF1inputinputRFX5 NRF1 RFX5input input inputRFX5input NRF1 RFX5inputinput NRF1 inputinput inputinput input input inputinput inputinput inputinput inputinput inputinput inputinput ETS1 BHLHE40inputinputinput inputBHLHE40inputinputETS1 BHLHE40inputinput ETS1input ETS1 inputinputinput BHLHE40 BHLHE40inputETS1inputinput inputinputETS1inputBHLHE40 BHLHE40inputinputinputETS1 BHLHE40ETS1inputinputinput BHLHE40ETS1 inputinputinput input inputSTAT3BHLHE40STAT1MAXSTAT1MAXEBF1 inputSTAT3BHLHE40EBF1inputSTAT1STAT1MAX MAXBHLHE40STAT1STAT1STAT3inputEBF1input inputinputSTAT1STAT3STAT1MAXMAXBHLHE40EBF1 BHLHE40inputMAXMAXSTAT3inputEBF1STAT1STAT1 EBF1 STAT1STAT1STAT3MAXMAXBHLHE40inputinput input STAT1BHLHE40STAT3STAT1MAXEBF1MAXinput EBF1BHLHE40STAT3MAXSTAT1inputinput BHLHE40STAT1STAT1MAXSTAT3MAXEBF1inputinput JUNDSTAT3GABPAGABPAETS1SRFELF1EBF1ELF1MXI1MXI1SRFSRF JUNDEBF1STAT3MXI1MXI1ELF1SRFSRFELF1ETS1GABPA SRFSRFGABPAGABPAMXI1ELF1MXI1ELF1SRFETS1STAT3EBF1 JUNDGABPA ELF1ELF1ETS1STAT3MXI1SRFJUNDSRFSRF EBF1 STAT3JUNDMXI1MXI1EBF1ETS1ELF1ELF1SRFSRFGABPAGABPA EBF1 ETS1SRFSRFSTAT3MXI1MXI1ELF1SRFGABPAGABPA JUND JUND MXI1ELF1SRFSTAT3SRFETS1ELF1SRFEBF1 GABPAGABPA GABPAGABPA ELF1ELF1EBF1SRFJUNDSRFETS1MXI1STAT3MXI1 JUND ETS1SRFELF1STAT3ELF1MXI1MXI1SRFEBF1SRFGABPAGABPA JUNDRXRARXRAZEB1SRFEGR1ZEB1PAX5 JUND RXRAPAX5ZEB1ZEB1SRFEGR1 EGR1ZEB1ZEB1PAX5RXRASRF JUND EGR1SRFRXRAJUNDZEB1ZEB1PAX5 JUNDEGR1RXRAZEB1PAX5ZEB1SRF PAX5ZEB1RXRAEGR1ZEB1RXRASRF JUND JUND RXRARXRAPAX5SRFEGR1ZEB1ZEB1 JUNDEGR1SRFPAX5ZEB1RXRAZEB1RXRA JUNDRXRARXRASRFZEB1EGR1ZEB1PAX5 IRF4SPI1IRF4RUNX3EBF1MEF2CPAX5PAX5EGR1 EBF1SPI1RUNX3IRF4IRF4PAX5MEF2CPAX5EGR1 EGR1PAX5PAX5MEF2CRUNX3IRF4IRF4SPI1EBF1 SPI1MEF2CIRF4RUNX3PAX5EGR1PAX5 EBF1 RUNX3EBF1IRF4IRF4SPI1MEF2CPAX5PAX5EGR1 EBF1 RUNX3PAX5MEF2CEGR1IRF4 SPI1 MEF2CPAX5SPI1PAX5EGR1RUNX3IRF4IRF4EBF1 SPI1EBF1IRF4PAX5RUNX3IRF4PAX5MEF2CEGR1 EGR1MEF2CRUNX3IRF4PAX5IRF4EBF1SPI1 BATFBCLAF1ZBTB33MEF2AATF2MEF2CRUNX3MEF2AATF2 EBF1PAX5EGR1 ZBTB33BATFATF2ATF2RUNX3MEF2APAX5EBF1MEF2CBCLAF1EGR1 EGR1MEF2CPAX5MEF2AMEF2ABCLAF1ZBTB33ATF2RUNX3EBF1ATF2BATF ZBTB33BCLAF1ATF2MEF2CMEF2AATF2RUNX3BATFPAX5EGR1 EBF1 BATFZBTB33RUNX3ATF2BCLAF1ATF2MEF2APAX5MEF2AEBF1MEF2CEGR1 EBF1 ZBTB33BCLAF1RUNX3PAX5EGR1MEF2AMEF2CMEF2AATF2ATF2BATF MEF2AZBTB33MEF2CMEF2AEGR1PAX5ATF2BCLAF1ATF2BATFRUNX3EBF1 EBF1BATFRUNX3BCLAF1PAX5ATF2MEF2AMEF2AEGR1MEF2CZBTB33 EGR1MEF2CMEF2ABCLAF1RUNX3ATF2ATF2BATFPAX5EBF1ZBTB33 BCLAF1STAT5AZBTB33NFATC1BATFNFATC1MTA3STAT5AYY1POU2F2SPI1BCL11APOU2F2TCF12BCL3 ZBTB33POU2F2POU2F2NFATC1NFATC1MTA3BCL11ASTAT5ASPI1STAT5ABATFBCL3YY1TCF12BCLAF1 POU2F2POU2F2BCL3TCF12NFATC1ZBTB33NFATC1YY1STAT5AYY1STAT5ABCL11ABCLAF1MTA3BATFSPI1 YY1 ZBTB33POU2F2BCLAF1POU2F2STAT5ASTAT5ASPI1NFATC1NFATC1MTA3BATFBCL3BCL11ATCF12 NFATC1MTA3NFATC1ZBTB33BCL11AYY1POU2F2STAT5APOU2F2BATFTCF12BCLAF1BCL3SPI1 POU2F2ZBTB33NFATC1STAT5ANFATC1TCF12BCL3BCL11ABCLAF1MTA3YY1YY1BATF SPI1 POU2F2POU2F2ZBTB33NFATC1BCL3SPI1BCL11ABATFSTAT5ABCLAF1TCF12STAT5AMTA3 YY1YY1 SPI1 POU2F2NFATC1NFATC1STAT5ABCLAF1MTA3BCL11ASTAT5ABATFBCL3TCF12ZBTB33 YY1 YY1 POU2F2STAT5ASTAT5ABCLAF1NFATC1BCL11ABCL3NFATC1TCF12BATFMTA3ZBTB33SPI1 SPI1MTA3BCL11ABCL3PMLTCF12 MTA3BCL11APMLPMLSPI1TCF12BCL3 TCF12PMLBCL3PMLBCL11AMTA3SPI1 PMLSPI1MTA3TCF12BCL11ABCL3 BCL11AMTA3PMLTCF12BCL3SPI1 TCF12PMLBCL11AMTA3BCL3 SPI1 BCL11ATCF12PMLPMLSPI1BCL3MTA3 SPI1 PMLMTA3BCL11APMLTCF12BCL3 PMLPMLTCF12BCL11AMTA3BCL3SPI1 POU2F2TCF3TCF3 POU2F2TCF3TCF3 TCF3POU2F2TCF3 POU2F2TCF3TCF3 POU2F2TCF3TCF3 POU2F2TCF3TCF3 POU2F2TCF3TCF3 POU2F2TCF3TCF3 POU2F2TCF3TCF3 ZNF143ZNF143 ZNF143 ZNF143 ZNF143ZNF143 ZNF143ZNF143 ZNF143ZNF143 ZNF143ZNF143 ZNF143ZNF143 ZNF143 SIX5 SIX5 SIX5 SIX5 SIX5 SIX5 SIX5 SIX5 SIX5 SIX5GABPAGABPA GABPA SIX5 GABPAGABPA SIX5 GABPASIX5 SIX5 GABPAGABPA SIX5 GABPAGABPA SIX5GABPAGABPA GABPAGABPA SIX5 SIX5 GABPAGABPA ETS1 ETS1ETS1 ETS1ETS1 ETS1ETS1 ETS1ETS1 ETS1ETS1 ETS1ETS1 ETS1ETS1 ETS1ETS1 ATF3ELF1EGR1TCF3SRFEGR1 TCF3EGR1EGR1ELF1SRF ATF3 ATF3TCF3EGR1SRFEGR1ELF1 ELF1 EGR1SRFATF3EGR1TCF3 ATF3 TCF3EGR1EGR1ELF1SRF TCF3 EGR1EGR1SRFELF1ATF3 ATF3 TCF3EGR1SRFEGR1ELF1 ELF1 EGR1SRFATF3TCF3EGR1 EGR1ATF3TCF3EGR1ELF1SRF BCLAF1ZEB1ATF3SRFUSF1SRFEGR1 BCLAF1EGR1ZEB1SRFSRF ATF3USF1 USF1 ATF3SRFEGR1ZEB1SRFBCLAF1 BCLAF1SRFSRFZEB1ATF3EGR1 USF1 USF1ATF3 BCLAF1ZEB1EGR1SRF BCLAF1ZEB1SRFEGR1SRFATF3USF1 ATF3EGR1BCLAF1SRFZEB1USF1 SRFSRFUSF1BCLAF1ATF3EGR1ZEB1 EGR1USF1BCLAF1SRFATF3ZEB1SRF BCLAF1SRFUSF1ELF1TCF12ZEB1input TCF12BCLAF1ZEB1SRFELF1input USF1 USF1 inputTCF12ZEB1ELF1SRFBCLAF1 ELF1 BCLAF1SRFinputZEB1TCF12 USF1 USF1 TCF12BCLAF1inputZEB1ELF1SRF inputTCF12BCLAF1ZEB1ELF1SRFUSF1 inputBCLAF1ELF1TCF12SRFZEB1USF1 ELF1USF1SRFBCLAF1inputTCF12ZEB1 USF1BCLAF1SRFTCF12ELF1ZEB1 input RXRARXRAMEF2AMEF2CBCL3MEF2AYY1MEF2CTCF12PAX5PAX5MAXSTAT1MAXEBF1inputNRF1 TCF12BCL3MEF2AMEF2CMEF2AYY1EBF1MEF2CPAX5PAX5RXRARXRASTAT1MAXinputNRF1 NRF1MAXinputTCF12MEF2CBCL3PAX5MEF2CSTAT1PAX5YY1RXRAMEF2AYY1MEF2AEBF1 YY1 NRF1STAT1inputRXRAMEF2CMEF2ATCF12MEF2CMAXPAX5PAX5MAXBCL3 EBF1 MAXMAXNRF1YY1TCF12MEF2ABCL3MEF2CMEF2AinputSTAT1EBF1RXRAPAX5PAX5MEF2C EBF1 TCF12inputNRF1STAT1BCL3PAX5PAX5MEF2AMEF2CYY1YY1RXRAMEF2ARXRAMAXMAX NRF1 RXRAMEF2AMEF2CMEF2ARXRAPAX5TCF12inputSTAT1MAXBCL3MAXEBF1 YY1YY1 EBF1TCF12MAXPAX5inputSTAT1PAX5MEF2CBCL3MEF2AMEF2ARXRAMEF2CRXRANRF1 YY1 YY1 MEF2CMEF2ARXRAMEF2CTCF12RXRASTAT1MAXBCL3MAXPAX5PAX5EBF1input NRF1 STAT5ARUNX3BCL11ATCF3STAT1BHLHE40USF2MXI1BCL3MXI1PAX5 TCF3BCL11ASTAT5ABCL3RUNX3PAX5PAX5BHLHE40MXI1STAT1 USF2 USF2BHLHE40MXI1TCF3MXI1BCL3PAX5PAX5BCL11ASTAT1STAT5ARUNX3 MXI1STAT5ASTAT1RUNX3TCF3BCL3BCL11APAX5PAX5USF2BHLHE40 USF2 BHLHE40BCL11AMXI1STAT5AMXI1RUNX3TCF3BCL3STAT1PAX5 TCF3STAT5ABCL3BCL11ARUNX3PAX5PAX5STAT1MXI1BHLHE40MXI1USF2 BHLHE40PAX5BCL3STAT1MXI1BCL11APAX5TCF3RUNX3STAT5AUSF2 USF2BCL11ABHLHE40RUNX3STAT5APAX5MXI1TCF3MXI1BCL3STAT1 USF2BHLHE40TCF3STAT5ABCL3RUNX3BCL11ASTAT1MXI1MXI1PAX5PAX5 SPI1IRF4IRF4BATFBHLHE40STAT5ARUNX3BCL11Ainput NRF1 BCL11ASPI1STAT5ABATFRUNX3IRF4BHLHE40inputNRF1 NRF1BHLHE40STAT5AinputBCL11ARUNX3BATFIRF4IRF4SPI1 NRF1STAT5AinputSPI1IRF4RUNX3BATFBCL11ABHLHE40 BHLHE40BCL11ASTAT5ARUNX3BATFNRF1IRF4IRF4SPI1input STAT5ABCL11ANRF1RUNX3inputBATFIRF4BHLHE40SPI1 NRF1 inputBHLHE40BCL11ASPI1BATFSTAT5ARUNX3IRF4IRF4 SPI1 BHLHE40STAT5AIRF4BCL11ARUNX3IRF4BATFinputNRF1 BHLHE40STAT5ABCL11ARUNX3BATFSPI1IRF4inputIRF4 NRF1 inputPOU2F2SPI1STAT3NFE2USF2NFATC1MTA3NFATC1MTA3POU2F2PMLSPI1ATF2EBF1POU2F2inputEBF1 POU2F2POU2F2MTA3NFATC1POU2F2PMLNFATC1MTA3SPI1ATF2SPI1EBF1STAT3inputEBF1inputinput NFE2USF2 USF2NFE2POU2F2POU2F2POU2F2PMLNFATC1PMLNFATC1inputMTA3ATF2MTA3STAT3inputEBF1SPI1inputEBF1 POU2F2PMLPOU2F2inputPOU2F2inputSPI1STAT3SPI1NFATC1NFATC1MTA3ATF2input NFE2USF2EBF1EBF1USF2NFE2 POU2F2NFATC1inputMTA3NFATC1MTA3STAT3inputPOU2F2inputPMLPOU2F2EBF1EBF1ATF2SPI1 EBF1EBF1POU2F2POU2F2NFATC1PMLNFATC1MTA3MTA3inputSTAT3inputATF2 inputUSF2NFE2SPI1SPI1 inputinputPOU2F2POU2F2NFATC1SPI1STAT3SPI1ATF2PMLPMLEBF1MTA3MTA3inputNFE2USF2EBF1 SPI1SPI1EBF1USF2POU2F2EBF1POU2F2NFATC1NFATC1PMLMTA3PMLMTA3STAT3ATF2inputNFE2inputinput POU2F2NFE2POU2F2USF2PMLPMLNFATC1NFATC1ATF2MTA3MTA3STAT3EBF1inputEBF1SPI1SPI1input input BATFSTAT3ZBTB33ZBTB33ATF2 ZBTB33ZBTB33ATF2BATFSTAT3 ZBTB33ZBTB33ATF2STAT3BATF ZBTB33ZBTB33STAT3ATF2BATF BATFZBTB33STAT3ZBTB33ATF2 ZBTB33ZBTB33ATF2STAT3BATF ZBTB33ATF2BATFSTAT3 BATFSTAT3ATF2ZBTB33ZBTB33 ATF2STAT3BATFZBTB33ZBTB33 EBF1 RFX5 EBF1RFX5 LV3 RFX5 EBF1 RFX5 EBF1 EBF1RFX5 EBF1 RFX5 RFX5 EBF1 EBF1RFX5 RFX5EBF1 NFE2inputinput RFX5 SP1 inputinputRFX5NFE2SP1 NFE2SP1RFX5inputinput inputinputRFX5 NFE2SP1 NFE2 inputinput RFX5 SP1 inputSP1inputRFX5 NFE2 RFX5SP1inputinputNFE2 NFE2inputRFX5inputSP1 SP1RFX5NFE2 inputinput input JUNDJUND JUNDJUNDinput 6% of variance input JUNDJUND inputJUNDJUND inputJUNDJUND input JUNDJUND JUND JUND input JUNDJUNDinput JUND JUND input IRF3 PBX3 PBX3 IRF3 PBX3IRF3 IRF3 PBX3 IRF3PBX3 PBX3IRF3 IRF3PBX3 IRF3PBX3 IRF3PBX3 IRF3SP1 PBX3 SP1PBX3IRF3 PBX3IRF3SP1 IRF3SP1PBX3 IRF3SP1PBX3 PBX3 IRF3SP1 SP1IRF3PBX3 PBX3IRF3SP1 SP1IRF3PBX3 FOS FOS FOS FOS FOS FOS FOS FOS FOS FOS FOS FOS FOS FOS FOS FOS FOS FOS

FOS FOS FOS FOS FOS FOS FOS FOS FOS JUND JUND JUND JUND JUND JUND JUND JUND JUND JUND JUND JUND JUND JUND JUND JUND JUND JUND ZNF143ZNF143 ZNF143 ZNF143ZNF143 ZNF143ZNF143 ZNF143ZNF143 ZNF143ZNF143 ZNF143ZNF143 ZNF143ZNF143 ZNF143 SIX5SIX5 SIX5SIX5 SIX5SIX5 SIX5 SIX5 SIX5 SIX5SIX5 SIX5SIX5 SIX5 EBF1 EBF1 EBF1 EBF1 EBF1 EBF1 EBF1 EBF1 EBF1 input BATFSTAT3 EBF1 BATFEBF1STAT3input inputBATFSTAT3EBF1 inputSTAT3BATF EBF1 inputBATFSTAT3EBF1 EBF1 STAT3BATFinput BATFinputSTAT3EBF1 EBF1BATFSTAT3input STAT3BATFEBF1input inputinput inputinput inputinput inputinput inputinput inputinput inputinput inputinput inputinput SPI1ETS1 inputEBF1 SPI1 EBF1inputETS1 inputEBF1SPI1 ETS1 ETS1 SPI1input EBF1 inputETS1EBF1SPI1 EBF1 ETS1input SPI1 inputSPI1EBF1ETS1 SPI1 EBF1ETS1input ETS1EBF1SPI1input inputIRF4SPI1STAT3IRF4RUNX3SPI1 SPI1RUNX3SPI1IRF4STAT3input STAT3SPI1SPI1inputRUNX3IRF4IRF4 inputSPI1STAT3SPI1IRF4RUNX3 STAT3inputRUNX3IRF4IRF4SPI1 RUNX3STAT3IRF4inputSPI1SPI1 input SPI1STAT3SPI1RUNX3IRF4IRF4 SPI1SPI1 IRF4STAT3RUNX3IRF4input RUNX3STAT3IRF4inputIRF4SPI1SPI1 BCLAF1BCLAF1ZBTB33ETS1BATFATF2MTA3RUNX3BCL11AIRF3SP1 BCL11ABCLAF1BCLAF1RUNX3BATFMTA3ZBTB33ATF2ETS1 SP1IRF3 IRF3SP1 ZBTB33ATF2MTA3BCL11ARUNX3BATFBCLAF1ETS1 ETS1ZBTB33BCLAF1BCLAF1MTA3ATF2IRF3RUNX3BATFBCL11ASP1 ZBTB33MTA3BCL11ARUNX3BATFATF2BCLAF1BCLAF1ETS1 IRF3SP1 ZBTB33IRF3BCL11ABCLAF1MTA3RUNX3ETS1SP1ATF2BATF ZBTB33BCLAF1ATF2BCL11ABATFBCLAF1RUNX3SP1MTA3ETS1IRF3 BCLAF1MTA3IRF3RUNX3BCL11ABCLAF1ETS1ATF2SP1BATFZBTB33 BCLAF1BCLAF1BCL11AETS1RUNX3ATF2SP1IRF3BATFMTA3 ZBTB33 STAT5AMEF2AMTA3BCL11AATF2RFX5EBF1 BCL11AMTA3STAT5AMEF2AEBF1ATF2 RFX5 RFX5ATF2MTA3BCL11ASTAT5AMEF2AEBF1 STAT5ARFX5MTA3ATF2MEF2ABCL11A EBF1 BCL11AMTA3STAT5AATF2MEF2AEBF1RFX5 EBF1 STAT5ABCL11AMTA3MEF2ARFX5ATF2 RFX5MEF2ABCL11AATF2MTA3STAT5AEBF1 EBF1MTA3BCL11ARFX5STAT5AATF2MEF2A MEF2ASTAT5ABCL11AATF2MTA3RFX5EBF1 inputRXRARXRAZBTB33NFATC1SRFNFATC1STAT5AMEF2AMEF2CSTAT1IRF3 NFATC1ZBTB33NFATC1STAT5AMEF2AMEF2CRXRARXRASRFSTAT1input IRF3 IRF3 ZBTB33NFATC1NFATC1STAT5AinputSTAT1MEF2AMEF2CRXRASRF ZBTB33inputSTAT5ASTAT1SRFNFATC1IRF3NFATC1RXRAMEF2AMEF2C NFATC1NFATC1ZBTB33STAT5AinputMEF2ASTAT1MEF2CRXRASRFIRF3 ZBTB33NFATC1IRF3STAT5ANFATC1STAT1inputMEF2CRXRAMEF2ARXRASRF RXRAMEF2AZBTB33MEF2CNFATC1RXRASTAT1STAT5AinputSRFIRF3 SRFIRF3NFATC1NFATC1STAT5AinputSTAT1MEF2CMEF2ARXRAZBTB33RXRA MEF2ARXRAMEF2CSTAT5ANFATC1RXRANFATC1SRFIRF3STAT1ZBTB33 input YY1POU2F2POU2F2TCF12SRFinputPAX5ZEB1PAX5STAT1PAX5RFX5 POU2F2POU2F2TCF12YY1PAX5PAX5PAX5ZEB1SRFSTAT1RFX5input RFX5POU2F2POU2F2inputPAX5STAT1PAX5PAX5YY1TCF12ZEB1SRF LV4 YY1 POU2F2POU2F2inputSTAT1SRFRFX5ZEB1PAX5PAX5TCF12PAX5 YY1POU2F2POU2F2TCF12PAX5STAT1inputPAX5ZEB1PAX5RFX5SRF POU2F2TCF12STAT1PAX5PAX5PAX5inputRFX5ZEB1YY1YY1SRF RFX5inputPOU2F2POU2F2PAX5STAT1TCF12SRFZEB1 YY1YY1 SRFPOU2F2RFX5PAX5PAX5STAT1PAX5TCF12inputZEB1 YY1 YY1 POU2F2SRFRFX5TCF12STAT1ZEB1PAX5PAX5input MEF2CBCL3ELF1PMLBCL3PAX5PBX3SP1 BCL3PMLBCL3MEF2CPAX5ELF1 PBX3SP1 PBX3SP1 PMLPMLPAX5BCL3BCL3MEF2CELF1 ELF1PMLMEF2CBCL3PAX5BCL3PBX3SP1 PMLBCL3BCL3PAX5MEF2CELF1 PBX3SP1 PBX3 PMLBCL3BCL3SP1PAX5MEF2CELF1 MEF2CPAX5BCL3PMLPMLELF1BCL3SP1 PBX3 ELF1PMLPMLPAX5PBX3BCL3SP1BCL3MEF2C MEF2CPMLPMLBCL3SP1PBX3ELF1BCL3PAX5 GABPAGABPAPOU2F2BHLHE40ZEB1TCF3ELF1TCF12MXI1MXI1EGR1 PBX3POU2F2TCF3TCF12EGR1ZEB1GABPABHLHE40MXI1ELF1 PBX3 PBX3 POU2F2BHLHE40TCF3MXI1TCF12MXI1ZEB1EGR1ELF1GABPA 5% of variance GABPA ELF1POU2F2MXI1TCF12ZEB1TCF3EGR1BHLHE40PBX3 BHLHE40POU2F2MXI1MXI1TCF12TCF3ZEB1EGR1ELF1GABPAGABPAPBX3 PBX3POU2F2TCF3TCF12ZEB1EGR1MXI1BHLHE40MXI1ELF1GABPAGABPA POU2F2BHLHE40MXI1TCF12EGR1TCF3ELF1ZEB1PBX3GABPAGABPA GABPAGABPA ELF1 POU2F2PBX3BHLHE40MXI1TCF3TCF12MXI1EGR1ZEB1 POU2F2BHLHE40EGR1TCF3TCF12ZEB1ELF1MXI1MXI1PBX3GABPAGABPA SRFFOSEGR1 EGR1SRF FOSFOS EGR1SRF SRFFOSEGR1 EGR1SRFFOS FOS EGR1SRF EGR1SRF FOS SRFFOSEGR1 EGR1FOSSRF NFE2 BHLHE40MAXMAXFOSinputinputNRF1 BHLHE40MAXinputinputNRF1NFE2 FOS FOS NFE2BHLHE40NRF1MAXinputinput NRF1inputinputFOSMAXMAXNFE2BHLHE40 NFE2 BHLHE40MAXMAXNRF1inputinput FOS inputinputFOSNRF1MAXMAXBHLHE40NFE2 NRF1 BHLHE40inputinputMAXMAXFOSNFE2 NFE2FOSBHLHE40inputMAXinput NRF1 BHLHE40FOSNFE2MAXMAX inputinput NRF1 ATF3EGR1SRF NRF1FOS EGR1SRFNRF1 ATF3 FOS FOS NRF1ATF3EGR1SRF NRF1EGR1SRFATF3 FOS ATF3 NRF1EGR1SRFFOS NRF1FOSEGR1SRF ATF3 NRF1 ATF3SRFEGR1FOS EGR1SRFFOSATF3 NRF1 FOSATF3EGR1SRF NRF1 NFE2 TCF3 TCF3 NFE2 NFE2 TCF3 TCF3NFE2 NFE2 TCF3 TCF3 NFE2 TCF3NFE2 NFE2TCF3 NFE2TCF3 ATF3USF2 USF2ATF3 USF2 ATF3 ATF3 USF2 USF2ATF3 USF2ATF3 ATF3 USF2 USF2ATF3 USF2ATF3 USF2 USF2 USF2 USF2 USF2 USF2 USF2 USF2 USF2 USF1 USF1 USF1 USF1 USF1 USF1 USF1 USF1 USF1 USF1 USF1 USF1 USF1 USF1 USF1 USF1 USF1 USF1 EBF1 EBF1 EBF1 EBF1 EBF1 EBF1 EBF1 EBF1 EBF1 EBF1 EBF1 EBF1 EBF1 EBF1 EBF1 EBF1 EBF1 EBF1 USF1BHLHE40USF1 EBF1 BHLHE40EBF1 USF1USF1 EBF1BHLHE40USF1USF1 USF1USF1 BHLHE40 EBF1 USF1USF1 BHLHE40EBF1 EBF1 BHLHE40USF1USF1 BHLHE40EBF1USF1USF1 EBF1USF1USF1BHLHE40 BHLHE40USF1USF1EBF1 USF2 USF2 USF2 USF2 USF2 USF2 USF2 USF2 USF2 BHLHE40EBF1USF2 BHLHE40EBF1 USF2 EBF1BHLHE40USF2 USF2 BHLHE40 EBF1 USF2 BHLHE40EBF1 EBF1 BHLHE40USF2 BHLHE40EBF1USF2 EBF1BHLHE40USF2 USF2BHLHE40EBF1 NFE2 TCF3 FOSPBX3TCF3 PBX3NFE2 FOS FOSPBX3 NFE2 TCF3 NFE2TCF3FOSPBX3 NFE2 TCF3 FOS PBX3 PBX3TCF3 FOS NFE2 TCF3FOSNFE2PBX3 PBX3FOSNFE2TCF3 NFE2FOSTCF3PBX3 NFE2 PBX3SP1 PBX3NFE2SP1 PBX3NFE2SP1 NFE2PBX3SP1 NFE2 PBX3SP1 PBX3 SP1 NFE2 SP1 PBX3NFE2 NFE2PBX3SP1 SP1PBX3NFE2 BCL11ABCL3BCL11ATCF12PAX5EGR1EGR1SP1 BCL11ABCL11ABCL3TCF12EGR1PAX5EGR1PAX5 SP1 SP1 BCL11ABCL11APAX5BCL3TCF12EGR1EGR1 EGR1EGR1PAX5BCL3TCF12PAX5BCL11ABCL11ASP1 BCL11ABCL11ATCF12BCL3PAX5EGR1 SP1 TCF12BCL11ABCL3PAX5PAX5SP1EGR1EGR1 PAX5EGR1BCL11APAX5EGR1BCL11ATCF12BCL3SP1 BCL11ABCL11APAX5SP1TCF12BCL3EGR1 EGR1EGR1BCL11ABCL11ATCF12SP1BCL3PAX5PAX5 BCL3PAX5MAX BCL3PAX5MAX BCL3MAXPAX5 MAXBCL3PAX5 MAX BCL3PAX5 BCL3PAX5MAX BCL3PAX5MAX MAXPAX5BCL3 BCL3MAXPAX5 MEF2AATF3BATFRUNX3MEF2AMEF2CTCF12PAX5MAXFOS TCF12RUNX3BATFMEF2AMEF2ARUNX3MEF2CPAX5MAX ATF3 FOSFOS RUNX3RUNX3BATFMEF2AMEF2CTCF12PAX5MAXATF3 ATF3 MAXFOSTCF12MEF2CPAX5MEF2AMEF2ARUNX3RUNX3BATF ATF3 MAXRUNX3TCF12BATFMEF2AMEF2CMEF2APAX5 FOS TCF12FOSRUNX3RUNX3PAX5MEF2AMEF2CMEF2ABATFMAX ATF3 ATF3MEF2AMEF2CMEF2APAX5TCF12BATFRUNX3RUNX3MAX FOS RUNX3RUNX3TCF12BATFATF3MAXFOSPAX5MEF2CMEF2AMEF2A MEF2AMEF2CTCF12RUNX3ATF3BATFMAXFOSPAX5 BATFJUNDIRF4IRF4NFATC1MEF2CZEB1TCF3ATF3ATF2ZEB1inputFOSIRF3 TCF3NFATC1MEF2CATF2BATFIRF4ZEB1JUNDinput ATF3IRF3 FOS FOS IRF3JUNDBATFNFATC1inputATF2IRF4IRF4TCF3MEF2CZEB1ZEB1ATF3 ATF3FOSTCF3ZEB1MEF2CZEB1NFATC1ATF2IRF3IRF4IRF4inputBATF JUND LV5 ATF3 BATFJUNDNFATC1inputTCF3IRF4IRF4ATF2ZEB1MEF2CZEB1FOSIRF3 TCF3NFATC1IRF3FOSMEF2CZEB1inputZEB1ATF2BATFIRF4 ATF3JUND JUND inputATF3NFATC1MEF2CATF2TCF3BATFIRF4IRF4FOSZEB1IRF3ZEB1 JUNDNFATC1FOSBATFIRF4IRF3TCF3ATF2IRF4ATF3inputZEB1MEF2CZEB1 JUNDMEF2CTCF3FOSATF3NFATC1ATF2IRF3ZEB1BATFZEB1IRF4IRF4input JUNDRXRASTAT5ARXRAATF2MTA3NFATC1MTA3 SRFinputRFX5 MTA3STAT5ANFATC1MTA3ATF2RXRARXRAJUNDSRFinputRFX5 JUNDRFX5NFATC1ATF2MTA3MTA3STAT5ARXRAinputSRF SRFinputNFATC1RFX5RXRASTAT5AMTA3MTA3ATF2 JUND JUNDMTA3NFATC1MTA3STAT5AATF2inputRXRARFX5SRF NFATC1inputSTAT5AMTA3MTA3RFX5RXRARXRAATF2SRF JUND JUNDRFX5RXRANFATC1RXRAinputATF2SRFMTA3STAT5AMTA3 SRFJUNDNFATC1MTA3MTA3STAT5ARFX5ATF2inputRXRARXRA JUND STAT5ARXRANFATC1RXRAATF2RFX5MTA3MTA3SRFinput STAT3BCLAF1STAT3SRFSTAT5APOU2F2SRFSTAT1EGR1IRF3STAT1RFX5SRFinput POU2F2BCLAF1STAT5AEGR1STAT3SRFSRFSTAT3SRFSTAT1inputRFX5 IRF3 IRF3RFX5POU2F2STAT3STAT3STAT5ASTAT1STAT1inputBCLAF1SRFSRFSRFEGR1 EGR1inputSRFPOU2F2STAT1STAT5ASTAT1IRF3SRFSRFRFX5BCLAF1STAT3STAT3 STAT3STAT3STAT5APOU2F2BCLAF1STAT1inputSTAT1EGR1RFX5SRFSRFIRF3 POU2F2IRF3STAT5AinputBCLAF1STAT1STAT1STAT3RFX5EGR1SRFSTAT3SRFSRF RFX5POU2F2STAT1STAT3inputBCLAF1STAT1STAT5ASTAT3SRFEGR1SRFIRF3 EGR1SRFSRFIRF3POU2F2STAT5ARFX5BCLAF1STAT3STAT3inputSTAT1 POU2F2BCLAF1STAT5ASRFSRFIRF3STAT1RFX5STAT1STAT3STAT3EGR1SRFinput BCLAF1inputSPI1SPI1ZBTB33POU2F2SPI1inputMXI1MXI1 POU2F2SPI1BCLAF1ZBTB33SPI1SPI1MXI1inputinput ZBTB33POU2F2SPI1inputSPI1inputSPI1MXI1MXI1BCLAF1 MXI1POU2F2MXI1ZBTB33inputinputBCLAF1SPI1SPI1 4% of variance ZBTB33MXI1POU2F2inputMXI1BCLAF1SPI1SPI1input POU2F2ZBTB33BCLAF1inputinputMXI1MXI1 SPI1SPI1SPI1 inputPOU2F2ZBTB33SPI1MXI1SPI1SPI1BCLAF1input SPI1SPI1 POU2F2BCLAF1MXI1inputMXI1inputZBTB33 POU2F2BCLAF1MXI1SPI1MXI1inputZBTB33SPI1SPI1 input inputinputZBTB33POU2F2PML POU2F2PMLZBTB33inputinputinput inputinputZBTB33POU2F2inputPMLPML POU2F2PMLPMLZBTB33inputinputinput POU2F2inputZBTB33inputinputPML POU2F2PMLZBTB33inputinput input inputPOU2F2ZBTB33PMLPMLinputinput POU2F2PMLPMLinputinputZBTB33input POU2F2PMLPML inputZBTB33inputinput input NRF1 inputNRF1 input NRF1 NRF1 input input NRF1 NRF1 input NRF1 input inputNRF1 input NRF1 ETS1 NRF1 ETS1NRF1 NRF1ETS1 NRF1 ETS1 NRF1ETS1 NRF1ETS1 NRF1 ETS1 ETS1 NRF1 ETS1 NRF1 ETS1ELF1 ELF1ETS1 ELF1ETS1 ELF1 ETS1 ETS1ELF1 ETS1 ELF1 ELF1ETS1 ELF1 ETS1 ETS1ELF1 ZNF143ELF1 ELF1 ZNF143 ELF1ZNF143 ELF1 ZNF143 ZNF143 ELF1 ZNF143 ELF1 ZNF143 ELF1 ELF1 ZNF143 ZNF143ELF1 ZNF143 ZNF143 ZNF143 ZNF143 ZNF143 ZNF143 ZNF143 ZNF143 ZNF143 YY1 YY1 YY1 YY1YY1 YY1 YY1YY1 YY1YY1 YY1 YY1 SIX5GABPAGABPASIX5 GABPA SIX5SIX5 GABPASIX5SIX5 GABPAGABPA SIX5SIX5 SIX5 GABPAGABPA SIX5 GABPAGABPA SIX5SIX5GABPAGABPA GABPAGABPA SIX5SIX5 SIX5 GABPAGABPA PBX3 PBX3 PBX3 PBX3 PBX3 PBX3 PBX3 PBX3 PBX3 PBX3SP1 PBX3SP1 PBX3SP1 PBX3SP1 PBX3SP1 PBX3 SP1 SP1 PBX3 PBX3SP1 SP1PBX3 GABPA SP1 GABPA SP1 SP1 GABPA GABPA SP1 GABPA SP1 SP1 GABPA SP1 GABPA GABPA SP1 SP1 GABPA GABPA GABPA GABPA GABPA GABPA GABPA GABPA GABPA GABPA IRF3IRF3 IRF3 IRF3IRF3 IRF3IRF3 IRF3IRF3 IRF3IRF3 IRF3IRF3 IRF3IRF3 IRF3IRF3 FOSFOS FOSFOSFOS FOS FOSFOS FOSFOS FOSFOS FOSFOS FOSFOS FOSFOS SRF SRF FOS SRFSRF FOS FOS SRFSRF FOSSRF SRF SRFSRF FOS FOSSRF SRF SRFFOSSRF SRFSRFFOS FOSSRF SRF ELF1SRFSRFEGR1EGR1 EGR1EGR1SRFELF1SRF EGR1EGR1SRFSRFELF1 EGR1SRFEGR1ELF1SRF ELF1 SRFSRF EGR1EGR1 EGR1SRFEGR1SRFELF1 EGR1EGR1SRFELF1 ELF1 SRFSRFEGR1 EGR1EGR1SRFELF1SRF MEF2CELF1 RFX5RFX5 MEF2CELF1RFX5RFX5 RFX5RFX5 MEF2CELF1 MEF2CELF1RFX5RFX5 ELF1 RFX5MEF2CRFX5 RFX5MEF2CRFX5ELF1 RFX5MEF2CELF1 ELF1 RFX5RFX5MEF2C MEF2CRFX5RFX5ELF1 RXRAMEF2AZEB1MEF2C MEF2AMEF2CZEB1RXRA MEF2CMEF2ARXRAZEB1 ZEB1MEF2CRXRAMEF2A RXRAMEF2AZEB1MEF2C MEF2AMEF2CRXRAZEB1 MEF2CMEF2ARXRAZEB1 MEF2CMEF2AZEB1RXRA MEF2AMEF2CRXRAZEB1 BCLAF1RXRABCLAF1BCL3MEF2ASTAT1EGR1inputPAX5ZEB1PAX5TCF3STAT1EBF1PAX5inputinput TCF3BCL3BCLAF1BCLAF1MEF2AEBF1PAX5PAX5PAX5EGR1PAX5ZEB1RXRASTAT1inputinputinput inputSTAT1PAX5MEF2ASTAT1EBF1BCL3RXRAPAX5PAX5inputBCLAF1ZEB1inputTCF3EGR1 TCF3EGR1inputinputPAX5BCL3ZEB1PAX5STAT1PAX5RXRAinputMEF2ASTAT1BCLAF1BCLAF1EBF1 BCLAF1BCLAF1inputSTAT1STAT1EGR1inputRXRAinputZEB1MEF2APAX5PAX5PAX5PAX5BCL3TCF3 EBF1 EBF1 TCF3inputinputBCLAF1STAT1BCL3PAX5PAX5PAX5STAT1inputZEB1EGR1MEF2ARXRA RXRAinputMEF2APAX5STAT1TCF3PAX5inputinputBCLAF1STAT1BCLAF1BCL3EGR1EBF1ZEB1 EBF1EGR1BCLAF1BCLAF1PAX5inputPAX5inputSTAT1PAX5TCF3inputBCL3MEF2AZEB1RXRA MEF2ABCLAF1RXRABCLAF1STAT1TCF3STAT1BCL3EGR1ZEB1PAX5PAX5inputEBF1inputinput SPI1ETS1SPI1IRF4RUNX3POU2F2SPI1ATF2POU2F2TCF12TCF12BCL3 EBF1 TCF12POU2F2SPI1POU2F2TCF12BCL3RUNX3SPI1RUNX3ATF2SPI1IRF4ETS1EBF1 POU2F2POU2F2SPI1ATF2SPI1EBF1RUNX3RUNX3IRF4SPI1TCF12BCL3TCF12ETS1 TCF12POU2F2POU2F2BCL3TCF12ATF2RUNX3ETS1RUNX3IRF4EBF1SPI1SPI1 ETS1POU2F2POU2F2SPI1SPI1ATF2TCF12RUNX3IRF4RUNX3BCL3TCF12 EBF1 LV6 EBF1POU2F2TCF12TCF12BCL3RUNX3ETS1RUNX3ATF2IRF4 SPI1SPI1SPI1 POU2F2POU2F2BCL3SPI1TCF12SPI1ATF2SPI1EBF1RUNX3TCF12RUNX3IRF4ETS1 SPI1SPI1 EBF1POU2F2RUNX3ETS1RUNX3ATF2IRF4TCF12BCL3TCF12 POU2F2TCF12BCL3ETS1RUNX3ATF2TCF12EBF1SPI1IRF4SPI1SPI1 IRF4STAT5AETS1STAT3ZBTB33NFATC1BATFATF2NFATC1STAT5ABCL11ATCF3EBF1BCL11A NRF1 TCF3BCL11ABCL11ASTAT5ANFATC1ZBTB33NFATC1STAT5ABATFATF2EBF1IRF4EBF1STAT3ETS1NRF1 EBF1ZBTB33NFATC1NFATC1STAT3ATF2EBF1BCL11ASTAT5ABCL11ASTAT5AIRF4NRF1BATFTCF3 ETS1 NRF1TCF3NFATC1ZBTB33NFATC1STAT5ABCL11ASTAT5ABCL11ABATFATF2STAT3IRF4ETS1EBF1EBF1 ETS1NRF1ZBTB33STAT5ASTAT5ASTAT3NFATC1NFATC1ATF2IRF4TCF3BATFBCL11AEBF1EBF1 EBF1EBF1TCF3ZBTB33NFATC1STAT5ANFATC1BCL11ANRF1ETS1STAT3ATF2BATFIRF4 NRF1 ZBTB33NFATC1STAT3BCL11AATF2BCL11ATCF3BATFSTAT5ASTAT5AIRF4ETS1EBF1EBF1 EBF1EBF1NFATC1NFATC1STAT5ABCL11AIRF4ETS1BCL11ASTAT5ASTAT3TCF3ATF2BATFZBTB33NRF1 TCF3STAT5ASTAT5ANFATC1BCL11ANFATC1ETS1ATF2BCL11ABATFSTAT3EBF1IRF4EBF1ZBTB33 NRF1 STAT3SIX5SIX5inputZBTB33POU2F2MTA3MTA3ZNF143YY1PMLMXI1MXI1input POU2F2MTA3PMLMTA3ZBTB33YY1STAT3MXI1inputinputinput SIX5SIX5ZNF143 ZBTB33POU2F2STAT3MTA3inputMTA3inputPMLPMLMXI1MXI1YY1 SIX5SIX5ZNF143 POU2F2MXI1MXI1PMLPMLYY1YY1inputMTA3ZBTB33MTA3inputinputSTAT3ZNF143SIX5SIX5 SIX5YY1ZNF143POU2F2ZBTB33PMLinputinputSTAT3MXI1MTA3input ZNF143 POU2F2PMLZBTB33MTA3SIX5MTA3inputYY1YY1inputSTAT3MXI1MXI1input ZNF143inputinputPOU2F2ZBTB33MXI1PMLPMLSTAT3MTA3MTA3inputSIX5SIX5 YY1YY1 POU2F2PMLMTA3PMLMTA3MXI1STAT3inputMXI1inputSIX5SIX5ZNF143ZBTB33input YY1 YY1POU2F2ZNF143PMLPMLMTA3MTA3STAT3SIX5MXI1MXI1inputinputZBTB33input JUNDBATFinputJUNDinput ZNF143 NRF1 BATFJUNDJUNDinputinputNRF1 ZNF143 JUNDJUNDinputinputBATFNRF1 ZNF143 NRF1 inputinputBATFZNF143JUNDJUND ZNF143 NRF1inputinputJUNDJUNDBATF 4% of variance ZNF143 NRF1inputinputBATF JUNDJUNDNRF1JUNDZNF143JUND BATFinputinput JUNDJUNDBATFinputinput ZNF143NRF1 JUND JUNDZNF143BATF inputinput NRF1 input BHLHE40BHLHE40MAXMAX BHLHE40BHLHE40inputMAX inputBHLHE40BHLHE40MAX BHLHE40MAXBHLHE40 input input MAXMAXBHLHE40BHLHE40 MAXMAXBHLHE40input BHLHE40BHLHE40MAXMAXinput BHLHE40BHLHE40MAXinput BHLHE40BHLHE40MAXMAX input

NFE2ATF3USF2 USF2ATF3NFE2 NFE2USF2ATF3 USF2NFE2ATF3 ATF3 NFE2USF2 USF2ATF3NFE2 ATF3 NFE2USF2 USF2ATF3NFE2 USF2NFE2ATF3 NFE2ATF3USF1USF1 USF1NFE2USF1ATF3 NFE2 USF1USF1ATF3 USF1USF1ATF3 NFE2 ATF3NFE2 USF1 USF1NFE2USF1ATF3 ATF3 USF1NFE2USF1 NFE2USF1USF1ATF3 USF1USF1ATF3NFE2 USF2 USF2 USF2 USF2 USF2 USF2 USF2 USF2 USF2 JUND JUND JUND JUND JUND JUND JUND JUND JUND

JUNDSPI1 SPI1 JUND JUND SPI1 SPI1 JUND SPI1JUND JUNDSPI1 JUND SPI1 SPI1 JUND JUND SPI1 SPI1 SPI1 SPI1 SPI1 SPI1 SPI1 SPI1 SPI1 SPI1 GABPA SPI1 SPI1GABPA SPI1 GABPA GABPA SPI1 GABPA SPI1 SPI1 GABPA SPI1 GABPA GABPA SPI1 SPI1GABPA GABPANFE2ATF3USF2USF1 GABPA NFE2USF1USF2ATF3 USF2NFE2 USF1ATF3GABPA USF1 ATF3USF2NFE2GABPA GABPA ATF3 NFE2USF2USF1 USF2USF1ATF3NFE2 GABPA ATF3 NFE2USF2USF1GABPA GABPA USF2USF1ATF3NFE2 NFE2USF2USF1ATF3 GABPA NFE2inputUSF1ATF3 input USF1NFE2ATF3 NFE2inputUSF1ATF3 USF1 ATF3NFE2 input inputATF3NFE2 USF1 NFE2USF1ATF3 input inputATF3 NFE2USF1 NFE2USF1ATF3input USF1ATF3NFE2input SRFBHLHE40ELF1ELF1BHLHE40USF2 BHLHE40BHLHE40SRFELF1 USF2 BHLHE40BHLHE40USF2ELF1SRFELF1 USF2BHLHE40BHLHE40ELF1ELF1SRF ELF1ELF1 SRF BHLHE40USF2BHLHE40 USF2 BHLHE40BHLHE40 ELF1ELF1SRF BHLHE40BHLHE40ELF1ELF1SRFUSF2 ELF1ELF1SRFBHLHE40USF2BHLHE40 USF2BHLHE40BHLHE40SRFELF1ELF1 input SRFMXI1 SRFMXI1input input MXI1SRF MXI1SRF input inputMXI1SRF inputMXI1 SRF MXI1inputSRF SRFMXI1input SRFMXI1input BATFSTAT3IRF4IRF4 MXI1MAXMAX BATFIRF4STAT3MXI1MAX BATFSTAT3IRF4IRF4MXI1MAX MAXMXI1 IRF4IRF4STAT3BATF STAT3MXI1IRF4BATFMAXMAX MAXMAXBATFSTAT3MXI1IRF4IRF4 MXI1MAXBATFMAXSTAT3IRF4IRF4 BATFIRF4IRF4STAT3MAXMXI1 MAXMAXSTAT3BATFMXI1IRF4IRF4 RXRARXRASTAT3MEF2ABATFATF2MEF2CZEB1MEF2AATF2MEF2CEGR1SRFEGR1 BATFMEF2AMEF2CMEF2AMEF2CATF2EGR1ZEB1EGR1RXRARXRASTAT3SRF STAT3ATF2ATF2BATFMEF2AMEF2CMEF2CRXRAZEB1EGR1EGR1SRF EGR1SRFEGR1ZEB1MEF2CMEF2CRXRAMEF2AMEF2AATF2BATFATF2STAT3 STAT3EGR1RXRAATF2MEF2CSRFMEF2AATF2ZEB1MEF2CBATFEGR1 STAT3BATFATF2ATF2MEF2AMEF2CMEF2AEGR1RXRAMEF2CZEB1EGR1SRF RXRAMEF2AMEF2CMEF2ARXRASTAT3ATF2EGR1ATF2BATFSRFEGR1ZEB1 EGR1SRFSTAT3ATF2BATFMEF2CMEF2AMEF2AEGR1RXRAMEF2CZEB1RXRA MEF2CEGR1MEF2ARXRAMEF2CRXRAATF2ATF2BATFZEB1STAT3EGR1SRF ETS1RUNX3YY1STAT1ZEB1inputRFX5SRFRFX5EGR1FOS YY1EGR1RUNX3ZEB1SRFSTAT1inputETS1RFX5RFX5 FOS FOS RFX5RFX5inputRUNX3STAT1YY1ZEB1EGR1SRFETS1 FOSEGR1SRFZEB1RFX5YY1STAT1YY1RFX5RUNX3ETS1input YY1 ETS1 STAT1RFX5SRFRFX5ZEB1inputRUNX3EGR1FOS inputYY1ETS1RUNX3STAT1ZEB1RFX5RFX5EGR1SRFFOS LV7 RFX5inputSTAT1EGR1RUNX3SRFFOSETS1ZEB1 YY1YY1 SRFETS1RFX5FOSRFX5RUNX3STAT1inputZEB1EGR1 YY1 YY1 EGR1FOSETS1RUNX3RFX5STAT1RFX5ZEB1SRFinput BCLAF1inputinputBCLAF1ETS1RUNX3BCL11ABCL3BCL11AinputPAX5PAX5STAT1PAX5SP1 BCL11ABCL11ABCL3BCLAF1BCLAF1RUNX3PAX5PAX5PAX5PAX5ETS1STAT1inputinputinput SP1 SP1inputBCL11AinputBCL11AinputRUNX3PAX5STAT1BCL3PAX5PAX5BCLAF1ETS1 PAX5BCL3PAX5STAT1PAX5inputBCL11AinputBCL11ABCLAF1BCLAF1RUNX3ETS1SP1input ETS1inputBCLAF1BCLAF1inputinputSTAT1RUNX3PAX5PAX5BCL11APAX5PAX5BCL3SP1 inputBCL11ABCL11AinputRUNX3BCLAF1BCLAF1ETS1BCL3PAX5STAT1inputPAX5PAX5 SP1 inputPAX5PAX5BCL11ABCLAF1STAT1BCL11ABCLAF1BCL3RUNX3SP1ETS1inputinput BCLAF1BCL11ARUNX3BCL11ABCLAF1ETS1PAX5inputSP1inputPAX5STAT1PAX5inputBCL3 BCLAF1BCLAF1BCL11AETS1RUNX3BCL11ASP1STAT1BCL3PAX5PAX5input inputinput SIX5SIX5inputZBTB33STAT5ANFATC1MTA3MTA3TCF12 NRF1NRF1SP1 MTA3STAT5ATCF12NFATC1MTA3ZBTB33 inputNRF1NRF1 SP1SIX5SIX5 SP1inputZBTB33NFATC1MTA3MTA3STAT5ANRF1NRF1TCF12SIX5SIX5 NRF1NRF1TCF12SP1NFATC1STAT5AMTA3ZBTB33MTA3input SIX5SIX5 SIX5 NRF1NRF1ZBTB33inputSTAT5ANFATC1MTA3TCF12SP1 NRF1inputZBTB33NFATC1MTA3MTA3STAT5ASIX5NRF1TCF12 SP1 2% of variance NRF1NRF1 ZBTB33NFATC1TCF12MTA3STAT5ASP1MTA3inputSIX5SIX5 NFATC1MTA3MTA3inputSTAT5ATCF12SP1SIX5SIX5ZBTB33NRF1NRF1 STAT5ANFATC1TCF12SP1MTA3MTA3SIX5 ZBTB33input NRF1NRF1 ZBTB33NFATC1STAT5ABCL3FOSIRF3input NFATC1ZBTB33STAT5ABCL3 input IRF3 FOS FOS IRF3 ZBTB33NFATC1STAT5ABCL3input FOSinputBCL3NFATC1ZBTB33STAT5AIRF3 ZBTB33STAT5ANFATC1inputIRF3FOSBCL3 NFATC1ZBTB33STAT5ABCL3input FOSIRF3 ZBTB33NFATC1BCL3inputSTAT5AFOSIRF3 FOSNFATC1STAT5AIRF3inputBCL3ZBTB33 FOSSTAT5ANFATC1BCL3IRF3 ZBTB33input POU2F2PMLPOU2F2TCF12IRF3input TCF12POU2F2POU2F2PML input IRF3 IRF3 POU2F2POU2F2PMLPMLTCF12input inputTCF12POU2F2POU2F2PMLPMLIRF3 PMLPOU2F2POU2F2IRF3inputTCF12 POU2F2PMLPOU2F2TCF12input IRF3 POU2F2POU2F2TCF12PMLinputPMLIRF3 IRF3POU2F2PMLPMLTCF12input POU2F2PMLPMLTCF12IRF3 input TCF3FOS TCF3 FOSFOS TCF3 TCF3FOS FOSTCF3 TCF3 FOS TCF3 FOS FOSTCF3 TCF3FOS POU2F2TCF3 POU2F2TCF3 POU2F2TCF3 POU2F2TCF3 POU2F2TCF3 POU2F2TCF3 POU2F2TCF3 POU2F2TCF3 POU2F2TCF3 EBF1 EBF1PBX3 PBX3 EBF1EBF1PBX3PBX3 PBX3PBX3EBF1EBF1 PBX3 EBF1EBF1 PBX3PBX3EBF1EBF1 EBF1EBF1 PBX3PBX3 EBF1EBF1PBX3PBX3 EBF1EBF1PBX3PBX3 PBX3EBF1PBX3EBF1 EBF1EBF1 EBF1EBF1 EBF1EBF1 EBF1EBF1 EBF1EBF1 EBF1EBF1 EBF1EBF1 EBF1EBF1 EBF1 ZNF143 ZNF143 ZNF143 ZNF143 ZNF143 ZNF143 ZNF143 ZNF143 ZNF143 ZNF143 ZNF143 ZNF143 ZNF143 ZNF143 ZNF143 ZNF143 ZNF143 ZNF143 YY1 YY1 YY1 YY1YY1 YY1 YY1 YY1YY1 YY1 YY1

GABPAGABPA GABPA GABPA GABPAGABPA GABPA GABPAGABPA GABPAGABPA GABPAGABPA GABPAGABPA USF1 USF1 USF1 USF1 USF1 USF1 USF1 USF1 USF1 SIX5NFE2SIX5 FOSPBX3 PBX3NFE2SIX5SIX5 FOSFOS PBX3NFE2 SIX5SIX5 NFE2FOSPBX3 SIX5SIX5 SIX5 FOSPBX3NFE2 NFE2 SIX5 FOS PBX3 PBX3FOSSIX5 NFE2 NFE2PBX3FOSSIX5SIX5 PBX3NFE2SIX5FOS USF1 PBX3 PBX3USF1 PBX3 USF1 USF1 PBX3 PBX3USF1 USF1 PBX3 PBX3 USF1 PBX3USF1 USF1 PBX3 ZEB1EBF1 IRF3 EBF1ZEB1 IRF3 IRF3 EBF1 ZEB1 ZEB1IRF3EBF1 IRF3ZEB1 EBF1 EBF1ZEB1 IRF3 EBF1 IRF3ZEB1 EBF1IRF3ZEB1 IRF3ZEB1EBF1 inputinputinputSTAT5AETS1NFE2USF2SRFEBF1ELF1USF2IRF3ZEB1FOSEBF1 STAT5AEBF1ZEB1SRFEBF1ELF1ETS1inputinputinput USF2NFE2USF2IRF3 FOS FOS IRF3inputinputEBF1USF2NFE2inputSTAT5AUSF2EBF1ZEB1SRFELF1ETS1 USF2USF2NFE2FOSELF1ZEB1IRF3inputSTAT5ASRFEBF1ETS1inputinputEBF1 ELF1ETS1inputinputinputSTAT5ASRFIRF3ZEB1FOS NFE2USF2EBF1USF2 EBF1USF2USF2NFE2 inputinputSTAT5AinputETS1EBF1EBF1ZEB1ELF1SRFFOSIRF3 EBF1EBF1 IRF3STAT5AFOSinputinputinputETS1ZEB1 ELF1USF2SRFUSF2NFE2 ELF1EBF1USF2SRFIRF3FOSUSF2inputETS1STAT5AinputinputNFE2ZEB1 USF2NFE2USF2STAT5AFOSSRFETS1IRF3ZEB1ELF1EBF1EBF1inputinputinput STAT3BCLAF1IRF4ETS1MTA3MTA3STAT5ARUNX3BCL11AEGR1 SP1FOS BCL11AMTA3BCLAF1STAT5ARUNX3MTA3RUNX3IRF4EGR1STAT3ETS1 SP1 FOS FOSSP1 STAT3MTA3BCL11ASTAT5AMTA3RUNX3IRF4RUNX3BCLAF1EGR1ETS1 EGR1FOS STAT5ABCL11ABCLAF1MTA3RUNX3ETS1MTA3RUNX3SP1IRF4STAT3 ETS1BCLAF1STAT5ASTAT3EGR1MTA3RUNX3IRF4RUNX3BCL11ASP1FOS STAT3MTA3BCL11AMTA3STAT5ARUNX3IRF4BCLAF1ETS1EGR1FOS SP1 STAT5ABCL11AMTA3BCLAF1MTA3RUNX3ETS1RUNX3SP1FOSEGR1STAT3IRF4 EGR1STAT5AMTA3BCLAF1MTA3IRF4RUNX3BCL11AFOSETS1RUNX3STAT3SP1 FOSSTAT5ABCLAF1BCL11AETS1RUNX3MTA3SP1MTA3STAT3EGR1IRF4 input BATFBCLAF1IRF4BATFBHLHE40BCL11ABCL3TCF3TCF12SRFMAXSTAT1SRFSRFEGR1EBF1 SP1 TCF3BCL11ABCL3TCF12BCLAF1BATFBATFEGR1IRF4BHLHE40SRFSRFSTAT1inputEBF1MAX SP1 inputSP1BATFBHLHE40EBF1BCL11AIRF4BATFTCF3STAT1BCL3MAXTCF12BCLAF1EGR1SRFSRF SRFMAXBHLHE40SRFEGR1TCF3BCL3TCF12SP1STAT1BCL11ASRFBCLAF1BATFIRF4EBF1BATFinput inputBCLAF1STAT1SRFSRFSRFBATFTCF3IRF4MAXBATFBCL11ATCF12EGR1BCL3SP1BHLHE40EBF1 BHLHE40inputMAXBATFBCL11ABATFTCF3TCF12BCLAF1IRF4EBF1BCL3STAT1EGR1SRFSRF SP1 EBF1TCF3TCF12BCL11ABCLAF1STAT1BCL3SP1SRFEGR1SRFBATFBATFIRF4MAXBHLHE40inputSRF SRFEBF1SRFBHLHE40BCL11ABATFBCLAF1TCF3IRF4BATFMAXSTAT1TCF12SP1BCL3EGR1input BHLHE40EGR1TCF3BCLAF1SRFBCL11ATCF12SP1BATFSTAT1BCL3MAXBATFEBF1IRF4SRFSRFinput SPI1ZBTB33POU2F2RXRASTAT3MEF2AZBTB33NFATC1ATF2MEF2CNFATC1ELF1POU2F2PMLSPI1ATF2MEF2CPOU2F2STAT1BHLHE40TCF12MXI1PAX5MXI1PAX5TCF3MAXPAX5inputEGR1input POU2F2TCF3TCF12POU2F2SPI1NFATC1POU2F2PMLZBTB33NFATC1MEF2CSPI1ZBTB33MEF2AEGR1MEF2CATF2PAX5PAX5PAX5RXRABHLHE40MXI1STAT3ELF1STAT1MAXinputinput ZBTB33ZBTB33POU2F2POU2F2NFATC1NFATC1STAT3ATF2ATF2SPI1PMLBHLHE40PMLSPI1STAT1MEF2CPAX5MEF2AMXI1TCF12MXI1MEF2CRXRAMAXPAX5PAX5inputinputELF1EGR1TCF3 BHLHE40TCF3inputMAXinputEGR1POU2F2TCF12MXI1POU2F2MXI1MEF2CPOU2F2PMLELF1NFATC1ZBTB33PAX5PMLMEF2CPAX5NFATC1RXRASTAT1MEF2AZBTB33ATF2ATF2STAT3SPI1SPI1 ELF1POU2F2ZBTB33ZBTB33PMLPOU2F2POU2F2MXI1SPI1STAT3SPI1STAT1NFATC1NFATC1inputRXRAATF2MEF2CinputATF2MEF2ATCF12MEF2CPAX5PAX5MAXPAX5EGR1TCF3BHLHE40 BHLHE40MAXPOU2F2ZBTB33NFATC1NFATC1ZBTB33MXI1STAT3POU2F2MXI1PMLPOU2F2TCF12ATF2ATF2SPI1STAT1SPI1PAX5inputMEF2CMEF2AinputTCF3PAX5RXRAPAX5MEF2CELF1EGR1 POU2F2TCF3POU2F2TCF12ZBTB33NFATC1inputPMLZBTB33NFATC1inputPAX5PAX5PAX5STAT1EGR1MEF2AMEF2CSTAT3RXRAATF2ATF2MXI1MAXBHLHE40MXI1ELF1SPI1SPI1 LV8 SPI1ELF1POU2F2POU2F2NFATC1NFATC1PMLPMLBHLHE40STAT3MXI1PAX5ATF2TCF12inputMAXMXI1PAX5inputSTAT1PAX5MEF2CTCF3MEF2AEGR1MEF2CZBTB33ZBTB33RXRA POU2F2BHLHE40EGR1MEF2CPOU2F2PMLMEF2APMLMEF2CTCF12NFATC1RXRANFATC1ATF2ATF2STAT1TCF3MAXELF1STAT3MXI1SPI1MXI1PAX5PAX5ZBTB33SPI1inputinputZBTB33 RXRASPI1MEF2ABCL3PAX5 BCL3MEF2ASPI1PAX5RXRA SPI1PAX5MEF2ABCL3RXRA BCL3PAX5RXRAMEF2ASPI1 SPI1RXRAMEF2ABCL3PAX5 BCL3MEF2ASPI1PAX5RXRA BCL3PAX5MEF2ARXRA SPI1 SPI1 PAX5BCL3MEF2ARXRA MEF2ARXRABCL3 PAX5SPI1 ATF3inputinputRFX5RFX5 inputRFX5inputRFX5ATF3 RFX5RFX5inputinput ATF3 ATF3 RFX5inputRFX5input inputRFX5RFX5inputATF3 ATF3 inputinputRFX5RFX5 inputRFX5RFX5input ATF3 2% of variance RFX5RFX5ATF3input ATF3RFX5RFX5inputinput JUNDinputATF3ZNF143 JUNDinput ATF3ZNF143 JUND input ATF3 ZNF143 ATF3 input ZNF143JUND ZNF143 inputJUNDATF3 ATF3 ZNF143JUNDinput ZNF143 inputATF3 JUND JUNDATF3inputZNF143 JUND ZNF143ATF3input ZNF143 ZNF143 ZNF143 ZNF143 ZNF143 ZNF143 ZNF143 ZNF143 ZNF143

JUND NRF1 JUND NRF1 JUND NRF1 NRF1 JUND NRF1 JUND JUNDNRF1 NRF1 JUND JUND NRF1 JUND NRF1

NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 YY1 YY1 YY1 YY1YY1 YY1 YY1 YY1YY1 YY1YY1 YY1

NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 ZNF143 NRF1 NRF1 ZNF143 NRF1 ZNF143 NRF1 ZNF143 ZNF143 NRF1 ZNF143NRF1 ZNF143 NRF1 NRF1 ZNF143 ZNF143 NRF1 inputZBTB33RXRAZBTB33ZNF143 ZBTB33ZBTB33RXRAinput ZNF143 ZBTB33ZBTB33inputRXRA ZNF143 ZBTB33RXRAZBTB33input ZNF143 ZNF143ZBTB33ZBTB33inputRXRA ZNF143ZBTB33ZBTB33inputRXRA ZNF143 ZBTB33ZBTB33RXRA input ZNF143inputZBTB33RXRA ZNF143RXRAinputZBTB33ZBTB33 input MEF2CZEB1 MEF2CZEB1input input MEF2CZEB1 ZEB1MEF2C input input MEF2CZEB1 input MEF2CZEB1 MEF2CZEB1input MEF2CinputZEB1 MEF2CZEB1 input SIX5SIX5RXRAMEF2AMEF2AMEF2CZEB1EGR1EGR1 MEF2AMEF2AEGR1MEF2CEGR1ZEB1RXRA SIX5SIX5 MEF2AMEF2CRXRAZEB1EGR1EGR1SIX5SIX5 EGR1EGR1ZEB1MEF2CRXRAMEF2AMEF2A SIX5SIX5 SIX5 RXRAZEB1MEF2AMEF2CEGR1EGR1 SIX5MEF2AMEF2CMEF2ARXRAZEB1EGR1 SIX5EGR1MEF2AMEF2CZEB1MEF2AEGR1RXRA RXRAMEF2AMEF2CMEF2AEGR1EGR1ZEB1SIX5SIX5 EGR1EGR1MEF2ARXRAMEF2CSIX5ZEB1 BCLAF1NFE2RUNX3BCL3BCL11ATCF12STAT1BHLHE40inputTCF12BCL3PAX5inputTCF3STAT1 TCF3TCF12BCL11ABCL3TCF12BCLAF1BCL3RUNX3PAX5BHLHE40STAT1inputinput NFE2 BCL11ANFE2inputRUNX3BHLHE40inputSTAT1TCF12STAT1BCL3BCL3PAX5TCF12BCLAF1TCF3 NFE2BHLHE40TCF3TCF12BCL3BCL3TCF12STAT1PAX5inputSTAT1BCL11ABCLAF1RUNX3input BCLAF1inputSTAT1STAT1TCF12inputRUNX3PAX5BCL3BCL11ATCF12BCL3TCF3NFE2BHLHE40 NFE2 BHLHE40inputBCL11ARUNX3TCF12TCF12BCLAF1BCL3STAT1BCL3TCF3STAT1inputPAX5 TCF3TCF12TCF12BCL3BCL11ABCLAF1STAT1BCL3RUNX3PAX5STAT1inputinputBHLHE40NFE2 BHLHE40inputinputBCL3STAT1TCF3PAX5TCF12BCLAF1STAT1BCL11ARUNX3TCF12BCL3NFE2 NFE2BHLHE40BCLAF1TCF12BCL11ABCL3RUNX3TCF12STAT1TCF3STAT1BCL3PAX5inputinput STAT3BCLAF1inputinputSTAT5AETS1STAT3IRF4ATF3BATFATF2BHLHE40NFATC1STAT5ARUNX3BCL11ATCF3POU2F2ATF3ATF2POU2F2MXI1PAX5MXI1MAXMAXPAX5inputRFX5FOSinputSP1PBX3SP1 TCF3BCL11APOU2F2STAT5ABCLAF1NFATC1POU2F2STAT5ARUNX3BATFATF2PAX5PAX5IRF4PAX5BHLHE40STAT3MXI1ETS1STAT3MAXinputinputinputinputRFX5PBX3ATF3SP1SP1ATF3 FOSFOS SP1PBX3inputSP1RFX5POU2F2POU2F2STAT3NFATC1STAT3ATF2BHLHE40STAT5AinputATF2BCL11ASTAT5ARUNX3IRF4BATFTCF3PAX5MXI1MXI1MAXPAX5inputBCLAF1inputATF3ATF3ETS1 ATF3ATF3inputMAXinputBHLHE40FOSMXI1TCF3POU2F2MXI1PBX3POU2F2PAX5NFATC1PAX5SP1PAX5RFX5STAT5ABCL11AinputSTAT5ABCLAF1ATF2RUNX3ETS1BATFSP1ATF2IRF4STAT3inputSTAT3 ETS1inputPOU2F2BCLAF1POU2F2inputSTAT5ASTAT3MXI1STAT5ASTAT3NFATC1inputATF2RFX5inputATF2RUNX3IRF4TCF3ATF3FOSMAXBATFPAX5MAXBCL11APAX5PAX5PBX3SP1SP1BHLHE40 ATF3ATF3 BHLHE40MAXMAXSTAT3inputBCL11ANFATC1MXI1STAT3POU2F2STAT5AinputMXI1POU2F2BATFRUNX3TCF3ATF2IRF4BCLAF1ETS1ATF2PAX5inputinputPAX5RFX5FOS SP1PBX3SP1 PBX3TCF3POU2F2FOSNFATC1inputSTAT5AinputBCL11ABCLAF1RUNX3ETS1PAX5SP1PAX5inputSP1inputRFX5STAT3ATF2ATF2BATFSTAT3IRF4MAXMXI1MAXBHLHE40MXI1ATF3ATF3 ATF3RFX5POU2F2ATF3POU2F2NFATC1PAX5BHLHE40STAT3MXI1BCL11APAX5ATF2inputinputATF2TCF3MAXBATFSTAT5ABCLAF1RUNX3MAXSTAT3IRF4STAT5ASP1SP1ETS1inputinputPBX3FOS BHLHE40POU2F2TCF3STAT5ASTAT5ABCLAF1NFATC1ATF3ETS1RUNX3ATF2ATF3BCL11ARFX5ATF2SP1BATFPBX3MAXSTAT3MAXSTAT3FOSMXI1MXI1PAX5IRF4PAX5inputinputinputinput BATFinputIRF4POU2F2ETS1NFATC1MTA3MTA3PMLUSF2USF1RFX5IRF3 FOS POU2F2MTA3PMLNFATC1MTA3BATFIRF4ETS1inputRFX5USF2USF1IRF3 FOS FOSIRF3RFX5inputBATFNFATC1POU2F2MTA3MTA3PMLIRF4USF2USF1ETS1 USF1 USF2 FOSPOU2F2PMLNFATC1MTA3RFX5MTA3IRF3IRF4ETS1inputBATF ETS1POU2F2inputPMLRFX5NFATC1MTA3IRF3IRF4BATF FOSUSF2USF1 USF1USF2 POU2F2inputBATFNFATC1MTA3MTA3PMLETS1IRF4RFX5FOSIRF3 POU2F2PMLNFATC1IRF3MTA3MTA3inputETS1FOSRFX5BATFIRF4USF2USF1 RFX5POU2F2NFATC1PMLBATFMTA3FOSMTA3IRF4ETS1USF2inputIRF3USF1 LV9 POU2F2USF2PMLFOSUSF1NFATC1ETS1MTA3RFX5IRF3MTA3BATFIRF4input JUNDNFE2JUNDUSF2SRFUSF1PMLSRFEGR1IRF3FOSEBF1 PBX3 PMLEGR1JUNDSRFJUNDSRFEBF1 USF1NFE2PBX3USF2IRF3 FOS FOS PBX3IRF3JUNDJUNDNFE2USF2EBF1PMLUSF1SRFSRFEGR1 USF1USF2EGR1NFE2FOSPBX3PMLIRF3SRFSRFEBF1 JUNDJUND PMLSRFEGR1IRF3JUNDSRFJUNDFOSNFE2PBX3USF2EBF1USF1 USF2NFE2USF1 JUNDJUNDPMLEBF1EGR1SRFSRFFOSIRF3 PBX3 PBX3EBF1IRF3PMLFOSEGR1SRFSRFUSF1NFE2USF2JUNDJUND JUND JUND PMLEBF1SRFEGR1FOSSRFUSF2IRF3PBX3NFE2USF1 JUND JUNDUSF2USF1PMLFOSSRFSRFIRF3NFE2EGR1EBF1PBX3 EBF1SRFEBF1SRF EBF1EBF1SRF EBF1EBF1SRF SRFSRF EBF1 EBF1 SRFSRF EBF1 EBF1 EBF1EBF1SRFSRF EBF1EBF1 SRFSRF SRFSRFEBF1 2% of variance SRFEBF1SRFEBF1 ELF1EBF1 EBF1ELF1 EBF1ELF1 ELF1 EBF1 ELF1 EBF1 EBF1ELF1 EBF1 ELF1 ELF1EBF1 ELF1EBF1 SPI1SPI1SPI1ELF1 SPI1SPI1SPI1ELF1 SPI1SPI1SPI1 ELF1 ELF1 SPI1SPI1 ELF1 SPI1SPI1 SPI1SPI1ELF1 ELF1SPI1SPI1SPI1 SPI1SPI1SPI1ELF1 ELF1SPI1SPI1SPI1

GABPA GABPA GABPA GABPA GABPA GABPA GABPA GABPA GABPA GABPA GABPA GABPA GABPA GABPA GABPA GABPA GABPA GABPA NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 NRF1 input input input input input input input input input input input input input input input input input input ZBTB33 ZBTB33 ZBTB33 ZBTB33 ZBTB33 ZBTB33 ZBTB33 ZBTB33 ZBTB33 GABPAGABPAinput GABPAinput input GABPA GABPAGABPA input GABPA input input GABPAGABPA input GABPAGABPA input GABPAGABPA GABPAGABPA input input ZBTB33 inputinput ZBTB33inputinputinput inputZBTB33inputinput inputinputZBTB33 input inputZBTB33inputinput inputZBTB33inputinput ZBTB33inputinput input ZBTB33inputinputinput inputinputinputZBTB33 SPI1SPI1input SPI1SPI1 input SPI1inputSPI1 SPI1input SPI1SPI1input inputSPI1 input SPI1SPI1 inputSPI1SPI1 SPI1SPI1 input EBF1inputEBF1 EBF1EBF1 input EBF1inputEBF1 inputEBF1EBF1 input EBF1EBF1 EBF1inputEBF1 EBF1EBF1 input input EBF1EBF1 EBF1EBF1input inputIRF4IRF4EBF1PAX5PAX5SRFPAX5SRF PBX3 PAX5IRF4PAX5PAX5EBF1SRFinput PBX3 PBX3 EBF1inputIRF4IRF4PAX5PAX5PAX5SRF SRFSRFPBX3PAX5PAX5PAX5IRF4IRF4inputEBF1 inputSRFSRFIRF4PAX5PAX5PAX5PBX3EBF1 inputEBF1IRF4IRF4PAX5PAX5PAX5SRFSRF PBX3 PBX3EBF1 PAX5PAX5SRFSRFIRF4input input PAX5PAX5SRFSRFIRF4IRF4EBF1PBX3 EBF1SRFPBX3IRF4PAX5IRF4PAX5PAX5input SPI1 ELF1MXI1MXI1PAX5EBF1 SPI1PAX5MXI1ELF1EBF1 EBF1SPI1PAX5MXI1MXI1ELF1 MXI1ELF1MXI1PAX5EBF1SPI1 ELF1 MXI1SPI1 PAX5 EBF1 MXI1MXI1EBF1SPI1PAX5ELF1 EBF1 PAX5MXI1MXI1ELF1 SPI1 MXI1PAX5SPI1EBF1ELF1 ELF1SPI1 EBF1MXI1PAX5MXI1 LV10 BATFSTAT3STAT3EGR1ZEB1FOS BATFEGR1ZEB1STAT3STAT3 FOSFOS BATFSTAT3STAT3ZEB1EGR1 EGR1FOSZEB1STAT3STAT3BATF STAT3STAT3EGR1ZEB1BATFFOS BATFSTAT3STAT3EGR1ZEB1 FOS FOS ZEB1STAT3EGR1STAT3BATF STAT3BATFSTAT3EGR1ZEB1FOS EGR1BATFSTAT3STAT3FOSZEB1 SIX5NFE2SIX5NFATC1BATFMTA3MTA3RUNX3ZEB1BCL11ABCL3ELF1TCF12STAT1MAXTCF3STAT1RFX5MAX PBX3 TCF3BCL11AMTA3BCL3TCF12NFATC1RUNX3BATFMTA3RUNX3ZEB1ELF1STAT1MAXRFX5PBX3NFE2SIX5SIX5 PBX3RFX5NFE2NFATC1MTA3MTA3BCL11ARUNX3RUNX3BATFSTAT1STAT1BCL3MAXTCF12ELF1ZEB1TCF3SIX5SIX5 TCF3MAXNFE2ZEB1PBX3BCL3TCF12ELF1STAT1NFATC1BCL11ASTAT1MTA3RFX5RUNX3MTA3RUNX3BATF SIX5SIX5 SIX5 ELF1 STAT1STAT1RFX5NFATC1MTA3ZEB1RUNX3RUNX3MAXBATFMAXBCL11ATCF12BCL3PBX3NFE2TCF3 NFE2 MAXMAXNFATC1BCL11AMTA3MTA3SIX5RUNX3BATFTCF12STAT1BCL3TCF3STAT1ZEB1RFX5ELF1 PBX3 PBX3TCF3NFATC1TCF12BCL11AMTA3SIX5STAT1MTA3RUNX3BCL3RUNX3STAT1RFX5ZEB1BATFMAXMAXELF1NFE2 RFX5NFATC1STAT1TCF3BCL11ASTAT1ELF1MAXBATFRUNX3TCF12BCL3RUNX3MAXMTA3MTA3ZEB1SIX5PBX3SIX5NFE2 ELF1NFE2NFATC1MTA3BCL11AMTA3RFX5RUNX3RUNX3PBX3BATFMAXSTAT1TCF12TCF3BCL3SIX5SIX5ZEB1 BCLAF1BCLAF1ETS1ATF3ATF2NFATC1STAT5AATF2BCL11AIRF3IRF3RFX5SP1 SP1 BCL11ABCLAF1NFATC1BCLAF1STAT5AATF2ETS1ETS1RFX5 SP1SP1IRF3ATF3 IRF3IRF3SP1SP1RFX5NFATC1ATF2BCL11ASTAT5AATF2BCLAF1ATF3ETS1 ATF3 NFATC1SP1RFX5STAT5AIRF3BCLAF1BCL11ABCLAF1ATF2ETS1IRF3SP1ATF2ETS1 ETS1ETS1BCLAF1BCLAF1STAT5ANFATC1IRF3ATF2RFX5IRF3ATF2ATF3BCL11ASP1SP1 ATF3 NFATC1BCL11ASTAT5AETS1ATF2BCLAF1BCLAF1ETS1ATF2RFX5 IRF3IRF3SP1SP1 NFATC1IRF3STAT5AIRF3BCL11ABCLAF1ETS1SP1SP1ETS1RFX5ATF2ATF2 ATF3 ATF3RFX5NFATC1ATF2BCLAF1ATF2BCL11ASTAT5ABCLAF1SP1SP1ETS1ETS1IRF3IRF3 IRF3NFATC1STAT5ABCLAF1ETS1IRF3BCL11ABCLAF1RFX5ETS1ATF2SP1ATF3SP1 1% of variance RXRASTAT5ARXRAMEF2ASRFBHLHE40MEF2APOU2F2ATF3MEF2CPOU2F2SRFTCF12BCL3 TCF12POU2F2STAT5APOU2F2BCL3MEF2AMEF2AMEF2CRXRARXRABHLHE40SRFSRF ATF3 POU2F2POU2F2BHLHE40STAT5AMEF2AMEF2CTCF12BCL3RXRASRFATF3SRF ATF3BHLHE40TCF12POU2F2POU2F2BCL3MEF2CRXRAMEF2ASRFMEF2ASTAT5ASRF POU2F2POU2F2STAT5ASRFSRFRXRAMEF2ATCF12MEF2CATF3BCL3BHLHE40 ATF3 BHLHE40POU2F2STAT5APOU2F2TCF12BCL3MEF2AMEF2CMEF2ARXRASRFSRF POU2F2TCF12STAT5ABCL3MEF2AMEF2CRXRAMEF2ARXRABHLHE40SRFSRFATF3 RXRAMEF2APOU2F2ATF3POU2F2MEF2CMEF2ABCL3RXRABHLHE40TCF12SRFSTAT5ASRF SRFPOU2F2BHLHE40STAT5ATCF12ATF3BCL3MEF2CMEF2AMEF2ARXRARXRA USF2MEF2CUSF1ZNF143ZNF143TCF3PMLBHLHE40USF1FOS FOS TCF3PMLMEF2CBHLHE40 USF1USF1USF2ZNF143 FOSFOS FOSFOS USF2PMLBHLHE40TCF3MEF2CUSF1USF1 ZNF143ZNF143USF1USF1USF2BHLHE40FOSFOSTCF3MEF2CPML ZNF143 ZNF143ZNF143 PMLMEF2CTCF3FOS FOSBHLHE40USF2USF1 USF2USF1USF1 BHLHE40ZNF143ZNF143PMLTCF3MEF2CFOSFOS ZNF143ZNF143 TCF3PMLFOSMEF2CFOSBHLHE40USF1USF2USF1 ZNF143ZNF143BHLHE40MEF2CPMLTCF3FOSFOSUSF2USF1USF1 USF2USF1FOSPMLUSF1BHLHE40FOSTCF3MEF2CZNF143ZNF143 NFE2PMLUSF2EGR1EGR1 PMLEGR1EGR1 USF2NFE2 NFE2PMLUSF2EGR1EGR1 USF2NFE2EGR1EGR1PML PML EGR1EGR1NFE2USF2 USF2NFE2 PML EGR1 PMLEGR1EGR1USF2NFE2 EGR1PMLEGR1NFE2USF2 USF2PMLNFE2EGR1 JUNDPOU2F2 POU2F2 JUND JUNDPOU2F2 POU2F2 JUND POU2F2JUND POU2F2JUND POU2F2 JUND JUND POU2F2 JUNDPOU2F2 YY1 YY1 YY1 YY1YY1 YY1 YY1 YY1YY1 YY1YY1 YY1

JUND JUND JUND JUND JUND JUND JUND JUND JUND