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Endoscopic Anti-Reflux Procedures

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Endoscopic Anti-Reflux Procedures TECHNOLOGY STATUS EVALUATION REPORT Endoscopic anti-reflux procedures MAY 2002 INTRODUCTION fluoroethylene paste, polymethylmethacrylate In order to promote the appropriate use of new or (PMMA), and ethylene vinyl alcohol with tantalum emerging technologies, the ASGE Technology (Enteryx Polymer, Enteric Medical Technologies, Committee has developed a series of status evalua- Inc., Palo Alto, Calif. and Boston Scientific tion papers. This process may present relevant International, Cedex, France).1-4 These materials information about these technologies to practicing are injected in a low-viscosity state through stan- physicians for the education and care of their dard or large-bore injection needles. Fluoroscopic patients. In many cases, data from randomized con- guidance may be used to monitor delivery and reten- trolled trials are lacking and only preliminary clini- tion of radio-opaque components. These methods are cal studies are available. Because this is a rapidly not approved by the Food and Drug Administration evolving area, practitioners should continue to mon- (FDA) for treatment of GERD and remain investi- itor the medical literature for subsequent data gational at the time of this writing. about the efficacy, safety, and social economic aspects of the technologies. Endoluminal plication Endoluminal plication uses mechanical techniques BACKGROUND to impede reflux by approximation of tissue at or Gastroesophageal reflux disease (GERD) results below the gastroesophageal junction. when there is increased exposure of the esophageal The EndoCinch (Bard, Billerica, Mass.) system is mucosa to reflux of gastroduodenal contents. GERD used through an oroesophageal overtube to create occurs in susceptible patients in whom there is an endoluminal gastroplication (ELGP) and is FDA- increased frequency, duration, and/or potency of approved for treatment of GERD. The EndoCinch refluxate. Pharmacotherapy is used to reduce the device is sold in a procedure kit, which contains the frequency, duration, and/or potency of refluxate. following single-use components: a suturing cap- Surgical approaches are used to create barriers to sule, 17-gauge needle, pusher wire, guidewire, impede reflux. Endoscopic or endoluminal approach- suture tags, suture loader, suture anchor delivery es are being developed to similarly impede reflux device, suture anchor loading tool, and suture and may be categorized into injection bulking, pli- threading tool. An EndoCinch handle and overtube cating, and radiofrequency techniques. are also required, and are reusable up to 25 and 50 times, respectively. TECHNOLOGY UNDER REVIEW An oroesophageal overtube (19.7-mm outside Injection bulking diameter, 30-cm length) is placed to facilitate passage Bulking agents are substances injected under endo- of the suturing device. The suture capsule is attached scopic guidance into the esophageal wall at the level to the tip of a 9-mm outside diameter endoscope and of the esophagogastric junction. Intended to impede loaded with a tilt-tagged suture. After positioning the reflux, the bulking effect results from a combination suture capsule over the selected site, suction through of the retained material and consequent tissue the external vacuum line is applied. Tissue is suc- response. A number of injectable bulking agents tioned into the capsule cavity, and the suture placed have been considered including collagen, polytetra- by the needle driver. Suction is released and the tis- VOLUME 56, NO. 5, 2002 GASTROINTESTINAL ENDOSCOPY 625 sue is withdrawn from the capsule. The procedure is ing its linear position. Fifteen to 25 lesion sets are repeated on an adjacent site. Drawing two adjacent typically created. sutured sites together creates a plication. Sutures are The mechanism of action of radiofrequency is cinched together with a ceramic plug and ring assem- reported to be a reduction in the frequency of lower bly. Additional sutures are deployed in either a linear esophageal sphincter relaxations, as well as a phys- or circumferential configuration. ical alteration in tissue compliance and wall thick- The ESD (Wilson-Cook Medical, Winston-Salem, ness of the gastroesophageal junction.6 N.C.) is an endoscopically assisted endoluminal Other attempts to augment gastroesophageal suturing device that is FDA-approved for soft-tissue junction form and function by injection of scle- apposition. The ESD system is single-use and rosants and thermal injury with Nd:YAG laser have includes a Sew-rite device, 2 quick-load sutures, a been described and abandoned.7 loading wire, 4 vacuum caps, 1 Tie-rite Knot device, EFFICACY AND EASE OF USE 2 knot-loaders, 1 external accessory channel, 1 seal cap, 1 scissors, and 1 vacuum cap remover.The endo- Injection bulking agents scope is inserted with the External Accessory PMMA was injected submucosally in 10 patients Channel (EAC) attached, and the operative site is with GERD who had abnormal esophageal acid determined. The Sew-Right Device is inserted into exposure while on proton pump inhibitor therapy.2 the EAC and advanced until viewed endoscopically. Patients with hiatal hernia greater than 3-cm, Tissue is aspirated into the vacuum cap, and while Barrett’s esophagus, and/or peptic stricture were maintaining suction, a lever is activated to deploy the excluded. All patients underwent pretreatment needle to which the suture is attached. When the lever assessment to rule out hypersensitivity to the injec- is released, the needle will retract placing the suture. tate. At 5 to 11 months’ follow-up (mean = 7.2 Suction is then discontinued, releasing the tissue. months), a statistically significant decrease in These steps are repeated for a second suture place- symptom severity score and mean total time with ment, followed by the knot tying process and the esophageal pH less than 4 was noted. cutting of excess suture material. Ethylene-vinyl alcohol injection for treatment of The Full-Thickness Plicator (Ndo Surgical, Inc, GERD is reported in 15 patients with heartburn, Mansfield, Mass.), is an endoluminal plication abnormal 24-hour pH, symptoms responsive to pro- device that deploys pre-tied implants to secure full- ton-pump inhibitor (PPI) therapy and return of thickness tissue apposition. The resultant single pli- symptoms after PPI discontinuation.4 Patients with cation is intended to enhance the valvular mecha- prior antireflux surgery, esophageal motility disor- nism of the gastroesophageal junction.5 A single ders, esophagitis greater than grade II, and obesity transluminal plication is placed near the gastro- were excluded. All procedures were performed esophageal junction under direct endoscopic visual- under fluoroscopic guidance with forward and side- ization. The resulting serosa-to-serosa tissue union viewing scopes. A 23 g, 4-mm injection needle was is intended to restore the valvular mechanism of the used to inject 1 to 2 mL of the biopolymer in 4 quad- gastroesophageal junction. This device is not FDA- rants close to the squamocolumnar junction to approved at the time of this writing. observe a ring fluoroscopically. Lower esophageal sphincter pressure was increased in 12 of 15 Radiofrequency patients measured 3 to 12 months after the proce- Stretta (Curon Medical Inc., Sunny Vale, Calif.) is an dure. Clinical heartburn score was improved at 1 endoscopically mediated endoluminal device that is and 6 months (p < 0.001). Four patients resumed FDA-approved for the treatment of GERD. The PPI use within 4 to 12 months. Stretta catheter comprises a wire-guided bougie-tip, a balloon-basket assembly, and 4 electrode delivery Endoluminal plication sheaths positioned radially around the balloon. The A multicenter trial evaluated 79 Endocinch proce- catheter is passed transorally and positioned at the dures for the treatment of GERD in 64 patients.8 Z-line. The balloon is inflated and 4 nickel-titanium Patients had 3 or more episodes of heartburn per needle electrodes (22 g, 5.5-mm length) are deployed week off medications, dependency on antisecretory into the luminal wall. Radiofrequency energy is medication, and abnormal 24-hour pH. Patients delivered while cooling the mucosa with iced saline with dysphagia, esophagitis greater than grade II, solution irrigation through a temperature-control- obesity, and/or hiatal hernia greater than 2 cm were ling generator. Additional lesion sets are created in excluded. Eleven patients required repeat procedure the region from 2 cm proximal to 1 cm distal to the for suboptimal results and 10 patients withdrew. In Z-line by rotating the catheter 45 degrees and vary- 47 patients with complete follow-up, gastroesopha- 626 GASTROINTESTINAL ENDOSCOPY VOLUME 56, NO. 5, 2002 Table 1. New technology APC Table 2. Hospital billing: new technology procedure/service APCs APC HCPCS APC title Payment rate HCPS SI APC Descriptor 0979 C9703 New technology-level X, $1625 $1500-$1750 C9701 T 980 Stretta procedure FINANCIAL CONSIDERATIONS geal reflux symptoms improved (p < 0.001). Twenty- four–hour pH monitoring at 3 and 6 months Injection bulking improved in 24 patients studied. Esophageal There are, as yet, no costs or charge data for the manometry and the mean grade of esophagitis were injection bulking materials or techniques. unchanged. There are no peer-reviewed data on the Ndo Full- Endoluminal plication Thickness Plicator or the Wilson-Cook ESD for EndoCinch: The EndoCinch single use procedure kit treatment of GERD at the time of this writing. lists for $1295. The handle lists for $1500 and the overtube for $150.
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