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Nonbacterial Causes of Lymphangitis with Streaking J Am Board Fam Med: first published as 10.3122/jabfm.2016.06.160015 on 9 November 2016. Downloaded from BRIEF REPORT Nonbacterial Causes of Lymphangitis with Streaking Brandon E. Cohen, MD, Arielle R. Nagler, MD, and Miriam Keltz Pomeranz, MD Background: Lymphangitic streaking, characterized by linear erythema on the skin, is most commonly observed in the setting of bacterial infection. However, a number of nonbacterial causes can result in lymphangitic streaking. We sought to elucidate the nonbacterial causes of lymphangitic streaking that may mimic bacterial infection to broaden clinicians’ differential diagnosis for patients presenting with lymphangitic streaking. Methods: We performed a review of the literature, including all available reports pertaining to non- bacterial causes of lymphangitic streaking. Results: Various nonbacterial causes can result in lymphangitic streaking, including viral and fungal infections, insect or spider bites, and iatrogenic etiologies. Conclusion: Awareness of potential nonbacterial causes of superficial lymphangitis is important to avoid misdiagnosis and delay the administration of appropriate care. (J Am Board Fam Med 2016;29: 808–812.) Keywords: Bacterial Infections; Diagnosis, Differential; Diagnostic Errors; Erythema; Iatrogenic Disease; Insects; Lymphangitis; MEDLINE; Mycoses; PubMed; Skin; Spider Bites Lymphangitic streaking is characterized by linear is important to avoid misdiagnosis, unnecessary an- copyright. erythema extending proximally toward regional tibiotic treatment, and a delay in the administration lymph nodes, reflecting underlying inflammation of appropriate treatments. Therefore we conducted of the superficial lymphatic vessels. Lymphangitic a comprehensive review of the literature to charac- streaking is most often described in association terize better the nonbacterial etiologies of lymp- with acute bacterial infections, such as Staphylococ- hangitic streaking. All relevant English-language cus aureus, Streptococcus pyogenes, and Pasteurella mul- reports available through the PubMed/MEDLINE tocida infections.1,2 Consequently, the presence of and Google Scholar databases were considered. lymphangitic streaking often leads clinicians to Search terms included the terms lymphangitic treat patients with systemic antibiotics.2 However, streaking, superficial lymphangitis,orcutaneous infec- http://www.jabfm.org/ superficial lymphangitis may also occur as a result tion, and one of the following terms: nonbacterial, of a variety of other nonbacterial etiologies, such as viral,orfungal infection. viral or fungal infections, arthropods bites, or iat- rogenic interventions (Table 1). The recognition of nonbacterial causes of lym- Viral Infections phangitic streaking can be challenging. Accord- on 24 September 2021 by guest. Protected Herpes simplex virus (HSV) has been reported to ingly, awareness of potential nonbacterial etiologies cause acute, superficial lymphangitis presenting with lymphangitic streaking. A number of reports of HSV of the upper extremity presenting with This article was externally peer reviewed. Submitted 8 January 2016; revised 19 May 2016; accepted lymphatic streaking show no evidence of bacterial 23 May 2016. superinfection.3–7 Lymphangitic streaking associ- From the New York University School of Medicine, New York, NY (BEC); and the Ronald O. Perelman Department ated with HSV may present along with systemic of Dermatology, New York University School of Medicine, symptoms such as fever and lymphadenopathy New York (ARN, MKP). 6,8 Funding: none. (LAD), further mimicking bacterial infection. In Conflict of interest: none declared. a number of the reported cases, patients were ini- Corresponding author: Miriam Keltz Pomeranz, MD, 240 E. 38th Street, 12th Fl., New York, NY 10016 ͑E-mail: tially misdiagnosed with a bacterial infection and [email protected]͒. treated with systemic antibiotics.4,7,8 808 JABFM November–December 2016 Vol. 29 No. 6 http://www.jabfm.org J Am Board Fam Med: first published as 10.3122/jabfm.2016.06.160015 on 9 November 2016. Downloaded from Table 1. Nonbacterial Causes of Lymphangitic infections is well documented, potential pathogenic Streaking mechanisms have not been proposed. Viral Herpes simplex Herpes zoster Fungal Infections Fungal Aspergillus species The lymphocutaneous form of sporotrichosis typ- Sporothrix schenckii ically manifests as nodular lymphangitis, character- Arthropod bites Insect bite ized by the development of linear, erythematous Pigeon tick bite 10–14 Spider bites lesions and subcutaneous nodules. However, Loxosceles reclusa (brown recluse spider) there have been reports of patients presenting with 15,16 Loxosceles arizonica lymphangitic streaks without nodules. In 1 Iatrogenic Tuberculosis purified protein derivative such case, a pediatric patient presented with tender test ulcers with raised borders and ascending lymp- Bacillus Calmette-Guérin vaccine hangitic streaks on the right upper extremity. The Cantharidin therapy patient was treated with antibiotics, and symptoms worsened. Culture revealed infection with Sporo- thrix schenckii, and the patient was successfully man- Gavelin and Knight4 reported a case of a nurse aged on oral itraconazole.15 who presented with tender, vesicular lesions of the Lymphangitic streaking has also been associated right thumb, lymphangitic streaking, and axillary with cutaneous Aspergillus infection. A 40-year-old LAD. The patient was originally treated with man with acute lymphoblastic leukemia receiving erythromycin; however, culture revealed HSV chemotherapy presented with a tender, edematous without bacterial infection. Antibiotics were dis- fifth toe with lymphangitic streaks along the dorsal continued and the lesions resolved 11 days after the 3 initial presentation. Dorman reported 2 patients copyright. presenting with recurrent herpes infection of the Figure 1. Erythematous patch with central bulla on the hand with superficial lymphangitis. Both patients ventral forearm, with a lymphangitic streak extending had similar clinical presentations; however, 1 pa- to the antecubital fossa in a patient with herpes tient was found to have a bacterial superinfection simplex virus infection versus a reaction to an requiring antibiotics, whereas the other patient was arthropod bite. (Photograph obtained by authors at diagnosed with HSV infection alone, highlighting New York University Langone Medical Center in the diagnostic challenge. A patient recently pre- January 2015.) sented at our institution with a recurrent, painful http://www.jabfm.org/ upper extremity bulla associated with a prominent lymphangitic streak. Initial treatment with levo- floxacin was unsuccessful and bacterial culture was negative. Skin biopsy suggested occult herpesvirus infection versus a vesicular arthropod reaction. Clinically, herpes simplex infection was favored given the recurrent lesions on the same extremity, on 24 September 2021 by guest. Protected lack of insect exposure, history of oral herpes in- fection, and responsiveness to acyclovir; however, a final diagnosis could not be made with certainty (Figure 1). Eruptions related to herpes zoster have also been described in association with lymphangitic streaking.7,9 However, clinical presentation and le- sion distribution allow a diagnosis of herpes zoster to be more easily distinguished from bacterial lym- phangitis compared with HSV. While superficial lymphangitis occurring in the setting of herpesvirus doi: 10.3122/jabfm.2016.06.160015 Nonbacterial Causes of Lymphangitis 809 J Am Board Fam Med: first published as 10.3122/jabfm.2016.06.160015 on 9 November 2016. Downloaded from foot. Cultures revealed infection with an Aspergillus with an uncomplicated arthropod bite can be suc- species without evidence of bacterial infection, and cessfully managed with antihistamines and/or top- the patient was ultimately managed on amphoteri- ical or oral steroids.20,23,24 cin B and itraconazole.17 In 1 case, a pediatric patient presented with prominent erythematous streaks extending from a Arthropod Bites lesion on the central abdomen toward the bilateral Noninfectious lymphangitic streaking may also oc- axilla, resembling a V shape. Dermoscopy of the cur after bites from various insects, ticks, and spi- initial macule at the vertex of the lesion revealed a ders.2,18–22 In general, lymphangitic streaking as- hemorrhagic center and crusted punctum, suggest- 20 sociated with an insect bite has not been reported ing an insect bite. In another case a patient pre- to present with systemic systems or LAD.2,18,20,21 sented with a pruritic lesion on the distal upper The mechanism of lymphangitis is proposed to be extremity that progressed to a red, tender linear secondary to either a hypersensitivity reaction or streak extending toward the axilla. The pigeon tick toxin injection.2,18,23,24 Certain patient popula- (Argas reflexus) was recovered from the site and tions, such as those with hematologic abnormali- identified. The patient was treated with antihista- ties, have a greater tendency to develop exagger- mines and oral steroids, and the lesion resolved 19 ated responses after arthropod bites. For instance, within 5 days. it has been well described that patients with chronic Spider bites, notably from those of Loxosceles lymphocytic leukemia tend to develop exaggerated species, are another cause of lymphangitic streaking responses to arthropod bites, which manifest as that can occur without associated bacterial infec- 22 vesicles or bullae with prominent edema
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