Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 14 August 2020 doi:10.20944/preprints202008.0308.v1 Manuscript (Review Article) A comprehensive review on inherited Sensorineural Hearing Loss and their syndromes Authors Muhammad Noman 1, Shazia Anwer Bukhari 1, Muhammad Tahir 2, & Shehbaz Ali 3* Author’s information 1 Department of Biochemistry, Molecular Biology laboratory, Government College, University, Faisalabad, 38000, Pakistan. 2 Department of Oncology, Allied Teaching Hospital Faisalabad, Faisalabad Medical University, Faisalabad, 38000, Pakistan. 3 Department of Biosciences and Technology, Khwaja Fareed University of Engineering and information technology, Rahim Yar Khan, Punjab, Pakistan. *Correspondence: Shehbaz Ali:
[email protected] Tel: +92-333-7477407 Abstract Hearing impairment is an immensely diagnosed genetic cause, 5% of the total world population effects with different kind of congenital hearing loss (HL). In third-world countries or countries where consanguineous marriages are more common the frequency rate of genetic disorders are at its zenith. Approximately, the incidence of hearing afflictions is ostensibly 7-8:1000 individuals whereas it is estimated that about 466 million peoples suffer with significant HL, and of theses deaf cases 34 million are children’s up to March, 2020. Several genes and colossal numbers of pathogenic variants cause hearing impairment, which aided in next-generation with recessive, dominant or X-linked inheritance traits. This review highlights on syndromic and non-syndromic HL (SHL and NSHL), and categorized as conductive, sensorineural and mixed HL, which having autosomal dominant and recessive, and X-linked or mitochondrial mode of inheritance. Many hundred genes involved in HL are reported, and their mutation spectrum becomes very wide.