United States Patent (19) 11 Patent Number: 6,075,120 Cheronis Et Al
USOO6075120A United States Patent (19) 11 Patent Number: 6,075,120 Cheronis et al. (45) Date of Patent: Jun. 13, 2000 54 BRADYKININ ANTAGONIST Cheronis et al., “Bradykinin antagonists: Synthesis and in vitro Activity of Bissuccinimidoalkane Peptide Dimers' 75 Inventors: John C. Cheronis, Lakewood; James Recent Progress on Kinins, (1992) pp. 551-558. K. Blodgett, Broomfield; Val Smith Whalley et al., “Novel Peptide Heterodimers Withactions. At Goodfellow; Manoj Vinayak Marathe, BK2 And Either u Opioid, NK1 Or NK2 Receptors: In Vitro both of Westminster; Lyle W. Spruce, Studies, British Journal of Pharmacology, vol. 109, Suppl., Arvada; Eric T. Whalley, Golden, all 19P, Jul 1993. of Colo. Vaverk et al., Suyccinyl Bis-Bradykinins: Potent Agonists 73 Assignee: Cortech, Inc., Denver, Colo. with Exceptional Resistance to Enzymatic Degradation, Peptide: Struc. and Func., Proceedings of the 8th Amer. Pept. Symp., Pierce Chem. Co., Rockford, IL, pp. 381-384 21 Appl. No.: 08/440,338 1983. 22 Filed: May 12, 1995 Stewart et al., Bradykinin Chemistry: Agonists and Antago nist, Advances in Experimental Medicine and Biology, Ple Related U.S. Application Data num Press, NY, NY pp. 585–589 1983. 63 Continuation of application No. 08/296,185, Aug. 29, 1994, Calixto et al., “Nonpeptide Bradykinin Antagonist, Brady which is a continuation of application No. 07/974,000, Nov. kinin Antagonists: Basic and Clinical Research, Ronald 10, 1992, abandoned, which is a continuation-in-part of Burch (Ed.), Marcel Dekker Inc., NY, NY, pp. 97-129 1991. application No. 07/859,582, Mar. 27, 1992, abandoned, which is a continuation-in-part of application No.
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