DOCSLIB.ORG

Global Assessment of Research in Neuroimaging WTEC Report on Europe and Asia Global Assessment of Research in Neuroimaging Global Assessment of Research

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text

Load more

GLOBAL ASSESSMENT OF RESEARCH IN NEUROIMAGING WTEC Report on Europe and Asia Global Assessment of Research in Neuroimaging Lilianne R. Mujica-Parodi (Chair) Peter A. Bandettini Tom Cortese National Institute Gary Glover of Mental Health Bin He Tor Wager Lawrence Wald GLOBAL ASSESSMENT OF RESEARCH IN NEUROIMAGING This study was sponsored by the U.S. National Science Foundation (NSF) and the Office of Naval Research (ONR). The National Institute of Mental Health provided the services of Dr. Peter Bandettini as in-kind support of the study. Dr. Lilianne R. Mujica-Parodi (Chair) Dr. Peter A. Bandettini Dept. of Biomedical Engineering Functional Imaging Methods Unit, Laboratory of Brain Stony Brook University School of Medicine and Cognition, National Institute of Mental Health Bioengineering Building, Rm. 119 Building 10, Rm. 1D80 Stony Brook, NY 11794-5281 10 Center Drive, MSC 1148 Bethesda, MD 20892-1148 Dr. Tom Cortese Dr. Gary H. Glover National Center for Supercomputing Applications Department of Radiology 1205 W. Clark St, M/C 257 The Lucas Center for MR Spectroscopy and Imaging Urbana, IL 61801 Mail Code 5488, Route 8 Stanford, CA 94305-5488 Dr. Bin He Dr. Tor Wager Department of Biomedical Engineering Department of Psychology and Neuroscience Institute for Engineering in Medicine 345 UCB University of Minnesota University of Colorado at Boulder 7-105 Hasselmo Hall, 312 Church St. SE Boulder, CO 80309-0345 Minneapolis, MN 55455 Dr. Lawrence Wald Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School Building 75, Room 2 109 13th Street Charlestown, MA 02129 Sponsor Representatives with WTEC Panels Ted Conway, Ph.D. (Europe and Asia) Monique E. Beaudoin, Ph.D. (Europe) General & Age Related Disabilities Engineering Associate Director Program (GARDE) Office of Naval Research Global The National Science Foundation London, UK 4201 Wilson Boulevard Arlington, VA 22230 Clayton Stewart, Ph.D. (Asia) Alex Leonessa, Ph.D. (Asia) Technical Director Associate Professor of Mechanical Engineering Office of Naval Research Global Virginia Tech London, UK Blacksburg, VA WTEC Participants in Site Visits Patricia Foland (Europe and Asia) R. D. Shelton (Europe) Vice President for International Operations and President Project Manager Hassan Ali (Asia) Independent Contractor WTEC Panel Report on GLOBAL ASSESSMENT OF RESEARCH IN NEUROIMAGING Final Report on Europe and Asia November 2014 Lilianne R. Mujica-Parodi (Chair) Peter A. Bandettini Tom Cortese Gary Glover Bin He Tor Wager Lawrence Wald Copyright 2014 by WTEC. This document was sponsored by the National Science Foundation (NSF) and other agencies of the U.S. Government under an NSF cooperative agreement (ENG 0844639) with the World Technology Evaluation Center (WTEC). The U.S. Government retains a nonexclusive and nontransferable license to exercise all exclusive rights provided by copyright. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the United States Government, the authors’ parent institutions, or WTEC. A list of available WTEC reports and information on obtaining them is on the inside back cover of this report. WORLD TECHNOLOGY EVALUATION CENTER, INC. (WTEC) R. D. Shelton, President Michael DeHaemer, Executive Vice President Frank Huband, Senior Vice President and General Counsel Geoffrey M. Holdridge, Vice President for Government Services Patricia Foland, Vice President for International Operations Grant Lewison, Advance Contractor Hasan Ali, Advance Contractor Haydon Rochester, Jr., Report Editor ACKNOWLEDGMENTS We at WTEC wish to thank all the panelists for their valuable insights and their dedicated work in conducting this global assessment of neuroimaging, and to thank all the site visit hosts for so generously sharing their time, expertise, and facilities with us. For their sponsorship of this important study, our sincere thanks go to the National Science Foundation and the Office of Naval Research and to the National Institute of Mental Health for providing the expert services of Dr. Peter Bandettini as an in-kind support of the study. R. D. Shelton President, WTEC WTEC Mission WTEC provides assessments of international research and development in selected technologies under awards from the National Science Foundation (NSF), the Office of Naval Research (ONR), and the National Institute of Standards and Technology (NIST). Formerly part of Loyola University Maryland, WTEC is now a separate nonprofit research institute. The NSF Deputy Assistant Director for Engineering is Program Director for WTEC. Potemtial sponsors interested in international technology assessments or related studies can provide support through NSF or directly through separate grants or GSA task orders to WTEC. WTEC’s mission is to inform U.S. scientists, engineers, and policymakers of global trends in science and technology. WTEC assessments cover basic research, advanced development, and applications. Panels of typically six technical experts conduct WTEC assessments. Panelists are leading authorities in their field, technically active, and knowledgeable about U.S. and foreign research programs. As part of the assessment process, panels visit and carry out extensive discussions with foreign scientists and engineers in their labs. The WTEC staff helps select topics, recruits expert panelists, arranges study visits to foreign laboratories, organizes workshop presentations, and edits and publishes the final reports. Dr. R. D. Shelton, President, is the WTEC point of contact: telephone 717 299-7130 or email [email protected]. iii TABLE OF CONTENTS List of Figures .......................................................................................................................................... v List of Tables .......................................................................................................................................... vii Preface ..................................................................................................................................................... ix Executive Summary ................................................................................................................................ xi 1. Introduction ........................................................................................................................................ 1 Background .......................................................................................................................................... 1 WTEC Background .............................................................................................................................. 2 Scope of the Study ............................................................................................................................... 2 Study Methods ..................................................................................................................................... 2 Overview of the Report ........................................................................................................................ 6 Acknowledgements .............................................................................................................................. 6 References ............................................................................................................................................ 6 2. MRI Acquisition Strategies for Advancing Neuroscience .............................................................. 7 Introduction to Ultra-High-Field fMRI Acquisition ............................................................................. 7 Field Strength Dependence of the Basic MR Signal ............................................................................ 7 Thermal and Physiological Noise ........................................................................................................ 8 BOLD Contrast Optimization and Changes with B0 .......................................................................... 11 Current State of the Art ...................................................................................................................... 14 Technological Focuses of the Sites Visited ........................................................................................ 15 Emerging Areas/Directions for the Future ......................................................................................... 20 References .......................................................................................................................................... 20 3. Multimodal Functional Neuroimaging and Neuromodulation .................................................... 23 Introduction ........................................................................................................................................ 23 Electrophysiological Mapping ........................................................................................................... 24 Electrophysiological Source Imaging ................................................................................................ 25 Multimodal Neuroimaging integrating fMRI and EEG/MEG ........................................................... 27 Neuromodulation ................................................................................................................................ 29 Discussion .........................................................................................................................................
Recommended publications
  • Carnegie Mellon University 5000 Forbes Ave. Scott Hall 4N120A

    Carnegie Mellon University 5000 Forbes Ave. Scott Hall 4N120A

    Bin He is the Trustee Professor and Head of the Department of Biomedical Engineering, and Professor by courtesy in the Department of Electrical and Computer Engineering, and Professor of the Neuroscience Institute at Carnegie Mellon University. Dr. He has made significant research and education contributions to the field of neuroengineering and biomedical imaging, including functional biomedical Carnegie Mellon University imaging, multimodal neuroimaging, and noninvasive brain-computer interface (BCI). 5000 Forbes Ave. His pioneering research has helped transforming electroencephalography from a 1- Scott Hall 4N120A dimensional detection technique to 3-dimensional neuroimaging modality. His lab Pittsburgh, PA demonstrated for the first time for humans to fly a drone and control a robotic arm just by thinking about it using a noninvasive BCI. He has contributed significantly to neuroengineering education including editing the first textbook in Neural Engineering, and led multiple NIH and NSF training grants in neuroengineering. Bin He received his BS in 1982 in electrical engineering, from Zhejiang University, Hangzhou, China. He later went to study in Japan and obtained his M.S. in electrical engineering and PhD (highest honors) in bioelectrical engineering from the Tokyo Institute of Technology. Bin He completed his postdoctoral fellowship at Harvard-MIT Division of Health Sciences and Technology in United States. After working as a Research Scientist at MIT, he later joined the faculty of Electrical Engineering and Bioengineering at the University of Illinois at Chicago, where Bin He was named a University Scholar by the university president. In January 2004, Bin He became the Professor of Biomedical Engineering at the University of Minnesota, Minneapolis.
  • September 21, 2018

    September 21, 2018

    CARNEGIE MELLON FORUM ON BIOMEDICAL ENGINEERING September 21, 2018 Department of Biomedical Engineering College of Engineering Carnegie Mellon University Scott Hall 5000 Forbes Ave Pittsburgh, PA 15213 www.bme.cmu.edu Program 8:30 – 9:00 Networking and Poster Viewing 9:00 – 9:05 Welcome Remarks Explore Frontiers in Burcu Akinci, Ph.D. Associate Dean for Research, College of Engineering Biomedical Engineering! Carnegie Mellon University 9:05 – 9:35 Keynote Lecture: Microphysiological Models that Rely on Emergence in Multi-Cellular Engineered Living Systems The Carnegie Mellon Forum on Roger D. Kamm, Ph.D. Cecil and Ida Green Distinguished Professor of Biological and Biomedical Engineering provides a platform for Mechanical Engineering Massachusetts Institute of Technology discussions and identification of grand challenges and Past Chair, International Academy of Medical and Biological Engineering Member, National Academy of Medicine frontiers in biomedical engineering research, education, Moderator: Bin He, Professor and Head, Department of Biomedical and translation. Engineering, CMU 9:35 – 10:05 Keynote Lecture: World’s Deepest-Penetration and Fastest Cameras: Photoacoustic Tomography and The forum consists of keynote and plenary talks, Compressed Ultrafast Photography plenary panel discussions, and poster presentations Lihong V. Wang, Ph.D. Bren Professor of Medical Engineering and Electrical Engineering in the frontiers of biomedical engineering. A poster California Institute of Technology Member, National Academy of Engineering award competition is open to students, postdocs Moderator: Marlene Behrmann, NAS, George A. and or residents who present their research in any Helen Dunham Cowan Professor of Cognitive Neuroscience, CMU area interfacing engineering with medicine 10:05 – 10:35 Keynote Lecture: Tackling Grand Challenges in Precision Medicine Through Biomedical Engineering and health.
  • Guest Editorial

    Guest Editorial

    IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING, VOL. 13, NO. 2, JUNE 2005 117 Guest Editorial FTER the tremendous clinical success of the cochlear A better understanding of neural control will eventually lead to A implant over the last 20 years, neuroprosthetic systems more elegant solutions for prosthetics and support of patients are now being developed and applied for the blind. First re- with CNS lesions. sults on implanted epiretinal arrays in humans are becoming This Special Issue is a collective effort by active researchers available now and lead to clear suggestions of how to improve who specialize in the field of neural engineering, and we hope it electrode design, device characteristics, and implant proce- will provide a rich resource with regard to the state-of-the-art of dures. Besides implants in humans and animals, research on neural engineering research. We are very grateful to a number in vitro neuronal network systems is progressively expanding. of colleagues who graciously volunteered to review papers Interesting combinations of multi-electrode array devices with for the special issue during their busy schedules. We also microfluidic systems will allow pharmacological control of wish to thank Dr. Robert Jaeger, Editor-in-Chief of the IEEE networks in a very precise way. Several papers in this Special TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION Issue of the IEEE TRANSACTIONS ON NEURAL SYSTEMS AND ENGINEERING, and Tracy Turner, Managing Editor, for their REHABILITATION ENGINEERING are related to various neural strong support and great effort, without which this Special Issue neuroprosthetic systems. would not be possible. Imaging has played an important role in understanding the mechanisms of neural systems and aiding clinical diagnosis and management of various neurological diseases.
  • THIRD CARNEGIE MELLON FORUM on BIOMEDICAL ENGINEERING September 18-19, 2020 Explore Frontiers in Biomedical Engineering!

    THIRD CARNEGIE MELLON FORUM on BIOMEDICAL ENGINEERING September 18-19, 2020 Explore Frontiers in Biomedical Engineering!

    THIRD CARNEGIE MELLON FORUM ON BIOMEDICAL ENGINEERING September 18-19, 2020 Explore Frontiers in Biomedical Engineering! The Carnegie Mellon Forum on Biomedical Engineering provides a platform for discussions and identification of grand challenges and frontiers in biomedical engineering research, education, and translation. This year’s forum is held virtually and consists of keynote and plenary talks as well as poster presentations in the frontiers of biomedical engineering. A poster award competition is open to students, postdocs or fellows who present their research in any area interfacing engineering with medicine and health. 1 Program FRIDAY, SEPTEMBER 18 Carnegie Mellon Forum on Biomedical Engineering 09:00 – 09:05 Welcome Remarks William H. Sanders William D. and Nancy W. Strecker Dean College of Engineering Carnegie Mellon University 09:05 – 09:20 Biomedical Engineering at Carnegie Mellon Bin He, IAMBE Trustee Professor and Department Head of Biomedical Engineering Carnegie Mellon University Chair, International Academy of Medical and Biological Engineering 09:20 – 09:50 Keynote: Statistical Inferences using Time-Frequency Methods and Control of Brain States Emery N. Brown, NAS, NAE, NAM, IAMBE Edward Hood Taplin Professor of Computational Neuroscience and Health Sciences & Technology Massachusetts Institute of Technology Moderator: Byron Yu, PhD Professor of Biomedical Engineering and Electrical & Computer Engineering Carnegie Mellon University 09:50 – 10:20 Keynote: Tissue Engineering for Impact in Medicine Gordana Vunjak-Novakovic, NAE, NAM University Professor and Mikati Foundation Professor of Biomedical Engineering and Medicine Columbia University Moderator: Charlie Ren, PhD Assistant Professor of Biomedical Engineering Carnegie Mellon University 10:20 – 10:30 BREAK 10:30 – 11:00 IAMBE New Fellow Induction Ceremony International Academy of Medical and Biological Engineering 11:00 – 11:30 Keynote: Bioengineering as a Role Model for How Convergence Will Advance Society’s Grand Challenges and Opportunities Kenneth R.