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Global Assessment of Research in Neuroimaging WTEC Report on Europe and Asia Global Assessment of Research in Neuroimaging Global Assessment of Research

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Global Assessment of Research in Neuroimaging WTEC Report on Europe and Asia Global Assessment of Research in Neuroimaging Global Assessment of Research GLOBAL ASSESSMENT OF RESEARCH IN NEUROIMAGING WTEC Report on Europe and Asia Global Assessment of Research in Neuroimaging Lilianne R. Mujica-Parodi (Chair) Peter A. Bandettini Tom Cortese National Institute Gary Glover of Mental Health Bin He Tor Wager Lawrence Wald GLOBAL ASSESSMENT OF RESEARCH IN NEUROIMAGING This study was sponsored by the U.S. National Science Foundation (NSF) and the Office of Naval Research (ONR). The National Institute of Mental Health provided the services of Dr. Peter Bandettini as in-kind support of the study. Dr. Lilianne R. Mujica-Parodi (Chair) Dr. Peter A. Bandettini Dept. of Biomedical Engineering Functional Imaging Methods Unit, Laboratory of Brain Stony Brook University School of Medicine and Cognition, National Institute of Mental Health Bioengineering Building, Rm. 119 Building 10, Rm. 1D80 Stony Brook, NY 11794-5281 10 Center Drive, MSC 1148 Bethesda, MD 20892-1148 Dr. Tom Cortese Dr. Gary H. Glover National Center for Supercomputing Applications Department of Radiology 1205 W. Clark St, M/C 257 The Lucas Center for MR Spectroscopy and Imaging Urbana, IL 61801 Mail Code 5488, Route 8 Stanford, CA 94305-5488 Dr. Bin He Dr. Tor Wager Department of Biomedical Engineering Department of Psychology and Neuroscience Institute for Engineering in Medicine 345 UCB University of Minnesota University of Colorado at Boulder 7-105 Hasselmo Hall, 312 Church St. SE Boulder, CO 80309-0345 Minneapolis, MN 55455 Dr. Lawrence Wald Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School Building 75, Room 2 109 13th Street Charlestown, MA 02129 Sponsor Representatives with WTEC Panels Ted Conway, Ph.D. (Europe and Asia) Monique E. Beaudoin, Ph.D. (Europe) General & Age Related Disabilities Engineering Associate Director Program (GARDE) Office of Naval Research Global The National Science Foundation London, UK 4201 Wilson Boulevard Arlington, VA 22230 Clayton Stewart, Ph.D. (Asia) Alex Leonessa, Ph.D. (Asia) Technical Director Associate Professor of Mechanical Engineering Office of Naval Research Global Virginia Tech London, UK Blacksburg, VA WTEC Participants in Site Visits Patricia Foland (Europe and Asia) R. D. Shelton (Europe) Vice President for International Operations and President Project Manager Hassan Ali (Asia) Independent Contractor WTEC Panel Report on GLOBAL ASSESSMENT OF RESEARCH IN NEUROIMAGING Final Report on Europe and Asia November 2014 Lilianne R. Mujica-Parodi (Chair) Peter A. Bandettini Tom Cortese Gary Glover Bin He Tor Wager Lawrence Wald Copyright 2014 by WTEC. This document was sponsored by the National Science Foundation (NSF) and other agencies of the U.S. Government under an NSF cooperative agreement (ENG 0844639) with the World Technology Evaluation Center (WTEC). The U.S. Government retains a nonexclusive and nontransferable license to exercise all exclusive rights provided by copyright. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the United States Government, the authors’ parent institutions, or WTEC. A list of available WTEC reports and information on obtaining them is on the inside back cover of this report. WORLD TECHNOLOGY EVALUATION CENTER, INC. (WTEC) R. D. Shelton, President Michael DeHaemer, Executive Vice President Frank Huband, Senior Vice President and General Counsel Geoffrey M. Holdridge, Vice President for Government Services Patricia Foland, Vice President for International Operations Grant Lewison, Advance Contractor Hasan Ali, Advance Contractor Haydon Rochester, Jr., Report Editor ACKNOWLEDGMENTS We at WTEC wish to thank all the panelists for their valuable insights and their dedicated work in conducting this global assessment of neuroimaging, and to thank all the site visit hosts for so generously sharing their time, expertise, and facilities with us. For their sponsorship of this important study, our sincere thanks go to the National Science Foundation and the Office of Naval Research and to the National Institute of Mental Health for providing the expert services of Dr. Peter Bandettini as an in-kind support of the study. R. D. Shelton President, WTEC WTEC Mission WTEC provides assessments of international research and development in selected technologies under awards from the National Science Foundation (NSF), the Office of Naval Research (ONR), and the National Institute of Standards and Technology (NIST). Formerly part of Loyola University Maryland, WTEC is now a separate nonprofit research institute. The NSF Deputy Assistant Director for Engineering is Program Director for WTEC. Potemtial sponsors interested in international technology assessments or related studies can provide support through NSF or directly through separate grants or GSA task orders to WTEC. WTEC’s mission is to inform U.S. scientists, engineers, and policymakers of global trends in science and technology. WTEC assessments cover basic research, advanced development, and applications. Panels of typically six technical experts conduct WTEC assessments. Panelists are leading authorities in their field, technically active, and knowledgeable about U.S. and foreign research programs. As part of the assessment process, panels visit and carry out extensive discussions with foreign scientists and engineers in their labs. The WTEC staff helps select topics, recruits expert panelists, arranges study visits to foreign laboratories, organizes workshop presentations, and edits and publishes the final reports. Dr. R. D. Shelton, President, is the WTEC point of contact: telephone 717 299-7130 or email [email protected]. iii TABLE OF CONTENTS List of Figures .......................................................................................................................................... v List of Tables .......................................................................................................................................... vii Preface ..................................................................................................................................................... ix Executive Summary ................................................................................................................................ xi 1. Introduction ........................................................................................................................................ 1 Background .......................................................................................................................................... 1 WTEC Background .............................................................................................................................. 2 Scope of the Study ............................................................................................................................... 2 Study Methods ..................................................................................................................................... 2 Overview of the Report ........................................................................................................................ 6 Acknowledgements .............................................................................................................................. 6 References ............................................................................................................................................ 6 2. MRI Acquisition Strategies for Advancing Neuroscience .............................................................. 7 Introduction to Ultra-High-Field fMRI Acquisition ............................................................................. 7 Field Strength Dependence of the Basic MR Signal ............................................................................ 7 Thermal and Physiological Noise ........................................................................................................ 8 BOLD Contrast Optimization and Changes with B0 .......................................................................... 11 Current State of the Art ...................................................................................................................... 14 Technological Focuses of the Sites Visited ........................................................................................ 15 Emerging Areas/Directions for the Future ......................................................................................... 20 References .......................................................................................................................................... 20 3. Multimodal Functional Neuroimaging and Neuromodulation .................................................... 23 Introduction ........................................................................................................................................ 23 Electrophysiological Mapping ........................................................................................................... 24 Electrophysiological Source Imaging ................................................................................................ 25 Multimodal Neuroimaging integrating fMRI and EEG/MEG ........................................................... 27 Neuromodulation ................................................................................................................................ 29 Discussion .........................................................................................................................................
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