Original Article

Cai‐Lei Matsumoto, MSc1, Sheldon Tobe, MD, FRCP, MScCH2,7, prevalence and Yoko S. Schreiber, MD FRCPC MSc (Epi) demographics in 25 CIP3,4, Natalie Bock‑ ing, MD, CCFP, RCP‐ communities in northwest SC5, Janet Gordon, PND1, Sharen Madden, Ontario (2014–2017) MD, MSc, CCFP, FCFP6, Josh Hopko1, Len Kelly, MD, MClin Sci, FCFP, FRRM8 Abstract Introduction: First Nations communities are known to have high rates of diabetes. 1Sioux Lookout First Nations Health Authority, The rural First Nations communities in northwest (NW) Ontario are particularly 2Division of Nephrology, affected. Regional studies in 1985 and 1994 found a high prevalence of diabetes. U of T Associate Scientist, More recently, they are estimated to have the highest prevalence in Ontario at 19%, Institute of Medical Science, double the provincial norm. The purpose of this study is to examine the epidemiol‑ University of Toronto, ogy and prevalence of diabetes in the total population and cardiovascular comor‑ 3Division of Clinical Sciences, Northern Ontario School of bidities in the adult population of 25 First Nations communities in NW Ontario. Medicine at Sioux Lookout Methods: This retrospective diabetes prevalence study used primary care electron‑ Meno Ya Win Health Centre, ic medical record data for a 3‑year period, 1 August 2014–31 July 2017. Diabetes 4Section of infectious diseases, prevalence was calculated for both the total and the adult (18+) populations and Max Rady College of Medi‐ comorbid hypertension and dyslipidaemia were identified in adults. cine, University of Manitoba, Winnipeg, 5Public Health Results: The age‑adjusted diabetes prevalence for the total population was 15.1% and Preventative Medicine versus a Canadian prevalence of 8.8%. The age‑adjusted adult prevalence was Specialist, Sioux Look‐out 14.1%, double Canada’s average of 7.1%. The average age of adults with diabetes First Nations Health was 52 years (±14.9); 57% were female. Comorbid hypertension (58%) and dys‑ Authority, Sioux Lookout, lipidaemia (73%) were common. Metformin was the most commonly used medica‑ Ontario, 6Division of Clinical Sciences, Northern Ontario tion (58%), followed by insulin/analogues (23%) and sulphonylureas (13%). School of Medicine, Thunder Conclusion: The diabetes prevalence in the First Nations population of NW On‑ Bay, Canada, 7Institute of tario is double Canada’s norm. Addressing it will require addressing relevant social Medical Science, University determinants of health, including poverty and food security. of Toronto, Toronto, 8Sioux Lookout Meno Ya Win Keywords: Diabetes, First Nations, prevalence Health Centre, Ontario

Correspondence to: Résumé Len Kelly, Introduction : Les communautés des Premières nations sont reconnues pour leur [email protected] taux élevé de diabète, particulièrement les communautés rurales des Premières nations du Nord‑Ouest de l’Ontario. Des études régionales réalisées en 1985 et This article has been peer reviewed. 1994 ont révélé une forte prévalence de diabète. Plus récemment, on a estimé que la prévalence dans ces communautés s’élevait à 19 %, la plus forte en Ontario et Access this article online le double de la norme provinciale. Cette étude visait à examiner l’épidémiologie

Quick Response Code: et la prévalence du diabète auprès de la population totale et les comorbidités

Received: 22-11-2019 Revised: 10-12-2019 Accepted: 19-07-2020 Published: ***

This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial- ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. For reprints contact: [email protected] Website: www.cjrm.ca 139 How to cite this article: Matsumoto C, Tobe S, Schreiber YS, Bocking N, Gordon J, Madden S, et al. DOI: Diabetes prevalence and demographics in 25 First Nations communities in northwest Ontario (2014–2017). 10.4103/CJRM.CJRM_99_19 Can J Rural Med 2020;25:139-44.

© 2020 Society of Rural Physicians of Canada | Published by Wolters Kluwer ‑ Medknow Can J Rural Med 2020;25(4) cardiovasculaires auprès de la population adulte de 25 communautés des Premières nations du Nord‑Ouest de l’Ontario. Méthodologie : Cette étude rétrospective visant à évaluer la prévalence du diabète a eu recours aux données sur 3 ans des dossiers médicaux électroniques des cliniques de première ligne, soit du 1er août 2014 au 31 juillet 2017. La prévalence du diabète a été calculée dans les populations totale et d’adultes (18 ans et plus) et l’hypertension et la dyslipidémie ont été dépistées en concomitance chez les adultes. Résultats: La prévalence du diabète ajustée en fonction de l’âge dans la population totale était de 15,1 % par rapport à la prévalence canadienne de 8,8 %. La prévalence ajustée en fonction de l’âge chez les adultes était de 14,1 %, soit le double de la prévalence canadienne de 7,1 %. L’âge moyen des adultes diabétiques était de 52 (±14,9) ans; et 57 % des participants étaient de sexe féminin. L’hypertension (58 %) et la dyslipidémie (73 %) étaient courantes en concomitance. La metformine était le médicament le plus fréquemment utilisé (58 %), suivie de l’insuline/analogues (23 %) et des sulfonylurées (13 %). Conclusion: La prévalence du diabète dans les populations des Premières nations du Nord‑Ouest de l’Ontario est le double de celle du Canada. Pour régler la situation, il faudra se pencher sur les déterminants sociaux de la santé pertinents tels que la pauvreté et l’insécurité alimentaire. Mots-clés: Diabète, Premières nations, prévalence

INTRODUCTION Setting and participants

First Nations communities are known to have The setting is 25 remote First Nations communities high rates of diabetes, particularly the rural First in NW Ontario, with a total population of 24,493, Nations communities in northwest (NW) Ontario. including 16,170 adults (18+). Each community Regional studies in 1985 and 1994 found a high receives primary care services from a local nursing prevalence of diabetes and in a 2019 International station, with regular visits from community Credential Evaluation Service report (ICES), physicians, supported by the Sioux Lookout First they are estimated to have the highest prevalence Nations Health Authority (SLFNHA). Patients in Ontario, at 19%, double the provincial norm of were included who had at least 1 primary care 8%.1‑3 These communities also have higher rates visit, at either one of the 25 nursing stations, of lower limb amputations (×7) and advanced or in the Sioux Lookout clinic, who were being kidney disease (×2).4‑6 An accurate description of investigated or treated for diabetes. Patients the regional scope of diabetes is needed to design under age 18 were not included in the analysis of appropriate initiatives and establish a baseline from comorbidities. which ongoing changes in disease presence can be measured. The purpose of this study is to examine Sources of data the and prevalence of diabetes in the total and adult population and associated Since 2013, all primary care clinical visits, cardiovascular comorbidities in diabetic adults in laboratory investigations and prescriptions 25 First Nations communities in NW Ontario. have been recorded in the OSCAR EMR in use by the practices of 30 community physicians. METHODS Data extraction and analysis was performed by the SLFNHA information technology Study design department (JH) and verified by its public health epidemiologist (CM). The SLMHC laboratory This retrospective diabetes prevalence study used performs all regional laboratory testing, with primary care electronic medical record (EMR) results automatically entered into the OSCAR. data for a 3‑year period, 1 August 2014–31 July Medication prescribing is done exclusively through 140 2017. Diabetes prevalence was calculated for both OSCAR and is linked to regional pharmacies. the total and the adult (18+) population. Comorbid Extracted data included demographics, hypertension and dyslipidaemia prevalence was laboratory results and prescribed medications. calculated for the adult population. A 3‑year time frame was chosen as most patients

Can J Rural Med 2020;25(4) with chronic conditions have at least one primary of 2960 patients were identified with diabetes, care visit in 2 years.7,8 Data collection protocol including 2888 adults. A1c testing occurred in approximated the validated Canadian Primary 32% of the total adult population (5161/16,170). Care Sentinel Surveillance Network methods, but Females received A1c testing more often, used a glycated haemoglobin level (A1c) of 6.5% 57% (2942/5161), and constituted 57% of the rather than 7.0%.9,10 Administrative data (physician adult diabetic population (1657/2888). billing and hospital diagnoses) were not used, but Adult diabetic patients had a mean the use of EMR prescription and laboratory data age of 52 years, 11 years older than the has been shown to render equivalent results.7 average adult age and had double the rate of comorbid hypertension (58%) and Variables dyslipidaemia (73%) [Table 1 and Figure 1]. The average adult A1c was 8.6 mmol/l; 29.5% Demographic and laboratory data included were ≤7.0%. The most common glucose‑lowering age, gender, low‑density lipoprotein‑cholesterol medication was metformin, followed by insulin (LDL‑C) and A1c. Prescribed medications were and sulphonylureas [Table 2]. identified by the World Health Organization The greatest increase in age group prevalence Anatomic Therapeutic Classification system.11 occurred in females aged 30–40 years, from This coding identifies all glucose and lipid‑lowering 8.9% at age 30–34 years to 20.2% at 35–39 years and antihypertensive medications. [Figures 2 and 3]. There was a wide range in Diabetes was defined as a recorded the adult prevalence among the 25 communities; A1c ≥6.5 mmol/l or a prescription of a crude rates varied from 9% to 32%. glucose‑lowering medication; hypertension was identified by the prescription of an DISCUSSION antihypertensive medication and dyslipidaemia by an elevated LDL‑C ≥ 2.0 mmol/L or the Prevalence prescription of a lipid‑lowering medication. The 15.1% overall age‑adjusted prevalence of Statistical methods diabetes in these 25 First Nations communities was higher than the 2017 Canadian prevalence of 8.8%.12 The prevalence of diabetes was adjusted to the 2016 While higher than national values, the prevalence is Canadian census population. The total population lower than that in other First Nations studies; our prevalence provided a comparator to national adult‑specific age‑adjusted prevalence of 14.4% values, but most of the analysis focused on the adult is higher than the Canadian adult prevalence of prevalence, allowing comparison with other First 7.1%, but is lower than the crude adult prevalence Nations and the estimation of comorbid hypertension of 27% in the James Bay Cree and 35% in a 2016 and dyslipidaemia. Data were presented as mean Manitoba First Nations screening study (our crude 13‑15 and standard deviation for continuous variables and adult prevalence was 18%). Methodological proportions for discrete variables. variations exist in these comparator studies; both relied primarily on A1c laboratory data. However, Ethics they used different cohorts: James Bay prevalence was estimated in the context of a proactive SLFNHA requested and approved the study. The community‑based diabetic programme, whereas Sioux Lookout Meno Ya Win Research Review a self‑referred screening population was used in and Ethics Committee (#16‑15) and the Lakehead Manitoba.14,15 It is not clear how these differences University Research Ethics Board (#161 15‑61) affect prevalence estimates, but First Nations approved the study. communities in NW Ontario appear to have a lower diabetes prevalence than other First Nations. Our RESULTS assumption that the 3‑year study period we used would identify most patients with diabetes seemed 141 The age‑adjusted population prevalence was 15.1%, appropriate; Grevier’s Canada‑wide primary care with an adult (18+) prevalence of 14.4%. A total EMR‑based study found that diabetic patients

Can J Rural Med 2020;25(4) 45 50.0 40 45.0 35 40.0

) 35.0 30 ) (% 25 (% 30.0 20 25.0

Prevalnce 20.0

15 Prevalnce 10 15.0 5 10.0 0 5.0 4 9

1- 5- 0.0 85+ 18-1920-29 30-3940-49 50-59 60-6970-79 80+ 10-14 15-19 20-24 25-29 30-34 35-39 40-44 45-49 50-54 55-59 60-64 65-69 70-74 75-79 80-84 Age Male 2.13.4 7.2 18.428.7 37.3 31.620.5 Sioux Lookout area First Nations Canada Female 3.35.7 14.3 26.537.3 39.7 44.825.1 Figure 1: Diabetes prevalence by age in 25 First Nations Figure 2: Adult (18+) diabetes prevalence by age and communities in northwest Ontario 2014-2017 and Canada, gender in 25 First Nations communities, northwest Ontario, 2013–2014 2014–2017.

Table 1: Demographics of total adult population and diabetic diabetic populations. The largest diabetic cohort adult population in 25 First Nations communities, northwest increase occurred in females in their 30s, where Ontario, 2014–2017 it doubled. Our regional population has a high Characteristics Total adult Diabetic adult birth rate, a high incidence of gestational diabetes population, n (%) population, n (%) and a high incidence of transition to overt Type 2 17‑19 n (%) 16,170 (100) 2888 (18) diabetes following gestational diabetes. These Mean age, SD 41 (16.9) 52 (14.9) contribute to the increased female prevalence of Female 8048 (50) 1657 (57) diabetes after age 30 and are consistent with a Comorbidities 1985 study of the same communities and other Hypertension 3935 (24) 1675 (58) recent First Nations studies, which demonstrated Dyslipidaemia 5210 (32) 2108 (73) a female preponderance20‑24 [Figure 2]. This SD: Standard deviation contrasts with national values with a higher prevalence in males25 [Figure 3]. Table 2: Adult use of diabetes medications (n=2888) Glycaemic control Class of drug % Biguanides (metformin) 58 The average A1c value in this adult diabetic population Insulin/analogues 23 Sulphonylureas 13 was 8.6%, higher than the 7.3%–8.2% in other DPP‑4 inhibitors 3 primary care studies, with First Nations populations Other medications 2 generally being at the higher end of that range15,26‑28 No medication 7 The target glycaemic control of A1c ≤7.0% was DPP‑4: Dipeptidyl peptidase 4 achieved in 29.5% of patients, compared to 39%– 51% in other primary care studies.28,29 Similarly, were 1.4 times more likely to have a primary care metformin was the most commonly prescribed visit in their 2‑year study period and the diabetes glucose‑lowering medication.29,30 programme in James Bay Cree communities found that 90% of the patients with diabetes had an A1c Comorbidities measurement within a 2‑year period.7,15 Hypertension co‑prevalence (58%) in First Age and gender Nations populations was similar to that in other Canadian diabetic populations (67.1%), but First Nations populations are known to well below the 92% found in a 2011 study of develop diabetes at an earlier age than other 19 Canadian First Nations communities, whose Canadians. 16 The age‑grouped results support methods included blood pressure measurement 142 this, demonstrating higher prevalence at data in addition to antihypertensive medication younger ages [Figure 1]. Women were equally records for 885 diabetic patients.26,31 overrepresented (57%) in both the AIC‑tested and Dyslipidaemia co‑prevalence of 73% was

Can J Rural Med 2020;25(4) 60.0

50.0

) 40.0 (%

30.0 Prevalence 20.0

10.0

0.0 1-45-9 10- 15- 20- 25- 30- 35- 40- 45- 50- 55- 60- 65- 70- 75- 80- 85+ 14 19 24 29 34 39 44 49 54 59 64 69 74 79 84 Sioux Lookout area Males 0.00.0 0.92.5 2.84.0 5.88.8 14.822.324.733.7 36.5 38.436.224.223.716.7 Sioux Lookout area Females 0.00.0 1.14.3 5.55.8 8.920.2 23.929.434.440.9 38.1 42.048.740.528.321.7 Canada Males 0.10.2 0.40.6 0.70.9 1.52.6 4.67.2 10.2 14.4 19.8 25.429.832.833.228.7 Canada Females 0.10.2 0.40.6 0.71.1 1.82.9 4.35.9 7.911.1 15.1 19.122.625.92724.1 Age Groups Figure 3: Diabetes prevalence (cases/100) by age and gender in 25 First Nations communities in northwest Ontario 2014–2017 and Canada, 2013-2014. between the 59% in Canada and 93% in other also precluded distinguishing between different First Nations studies.27,31 classes of diabetes. We assumed a stable population as most communities are geographically isolated; Context but participation in the study did include northern patients who have moved to Sioux Lookout and Estimates of diabetes prevalence tell only part some Sioux Lookout area residents. of the story. The First Nations population experience increased diabetes‑related morbidity CONCLUSION and mortality.32 Many factors contribute to this disease burden, including cultural and social The 25 First Nations communities in NW Ontario determinants of health, poverty and food insecurity. have a diabetes prevalence twice the Canadian Historic and political factors include inequities average. Patients diagnosed with diabetes were in employment and education, marginalisation, younger, included more females and had significant racism and intergenerational trauma resulting from levels of comorbid hypertension and dyslipidaemia. governmental assimilation practices.33‑37 A similar Social determinants of health and food security will disease profile exists in culturally and geographically need a culturally appropriate broad‑based approach distinct First Nations communities across Canada to address the environment in which diabetes thrives. which reflects the impact of this shared history of 33,36,37 colonisation and its ongoing detrimental effects. Financial support and sponsorship: This work was support‑ Addressing these factors requires broad social ed by the Northern Ontario Academic Medicine Association. and healthcare responses. The wide range of community‑specific prevalence requires further Conflicts of interest:There are no conflicts of interest. examination to understand how genetic, epigenetic or environmental factors affect rates of diabetes.38 REFERENCES

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