RESEARCH ARTICLE Long-Latency Somatosensory Evoked Potentials of the Subthalamic Nucleus in Patients with Parkinson's Disease Carlos Trenado1,2, Saskia Elben1,2, Lena Friggemann1, Sonja Gruhn1, Stefan Jun Groiss1,2, Jan Vesper3, Alfons Schnitzler1,2, Lars Wojtecki1,2* 1 Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany, 2 Department of Neurology, University Clinic, Heinrich Heine University, Duesseldorf, a1111111111 Germany, 3 Department of Functional and Stereotactic Neurosurgery, University Clinic, Heinrich Heine a1111111111 University, Duesseldorf, Germany a1111111111 a1111111111 *
[email protected] a1111111111 Abstract Somatosensory evoked potentials (SSEPs) are a viable way to measure processing of OPEN ACCESS somatosensory information. SSEPs have been described at the scalp and the cortical level Citation: Trenado C, Elben S, Friggemann L, Gruhn by electroencephalographic, magnetoencephalographic and intracranial cortical recordings S, Groiss SJ, Vesper J, et al. (2017) Long-Latency focusing on short-latency (SL; latency<40 ms) and long-latency (LL; latency>40 ms) SSEPs Somatosensory Evoked Potentials of the as well as by deep brain stimulation (DBS) electrode studies targeting SL-SSEPs. Unfortu- Subthalamic Nucleus in Patients with Parkinson's Disease. PLoS ONE 12(1): e0168151. doi:10.1371/ nately, LL-SSEPs have not been addressed at the subcortical level aside from the fact that journal.pone.0168151 studies targeting the characteristics and generators of SSEPs have been neglected for the Editor: Robert Chen, University of Toronto, last ten years. To cope with these issues, we investigated LL-SSEPs of the subthalamic CANADA nucleus (STN) in twelve patients with Parkinson's disease (PD) that underwent deep brain Received: June 5, 2016 stimulation (DBS) treatment.