molecules Article Effect of the Addition of Alginate and/or Tetracycline on Brushite Cement Properties Claudia Morilla 1,2,3, Elianis Perdomo 4, Ana Karla Hernández 1, Ramcy Regalado 1, Amisel Almirall 1, Gastón Fuentes 1,2,* , Yaima Campos Mora 1,2, Timo Schomann 2,3 , Alan Chan 3 and Luis J. Cruz 2 1 Biomaterials Center, University of Havana, La Habana 10400, Cuba;
[email protected] (C.M.);
[email protected] (A.K.H.);
[email protected] (R.R.);
[email protected] (A.A.);
[email protected] (Y.C.M.) 2 Translational Nanobiomaterials and Imaging Group, Department of Radiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands;
[email protected] (T.S.);
[email protected] (L.J.C.) 3 Percuros B.V., 2333 CL Leiden, The Netherlands;
[email protected] 4 Faculty of Automatic and Biomedical Engineering, Technological University of Havana, La Habana 11300, Cuba;
[email protected] * Correspondence:
[email protected] or
[email protected] Abstract: Calcium phosphate cements have the advantage that they can be prepared as a paste that sets in a few minutes and can be easily adapted to the shape of the bone defect, which facilitates its clinical application. In this research, six formulations of brushite (dicalcium phosphate dihydrated) cement were obtained and the effect of the addition of sodium alginate was analyzed, such as its capacity as a tetracycline release system. The samples that contain sodium alginate set in 4 or 5 min Citation: Morilla, C.; Perdomo, E.; and showed a high percentage of injectability (93%).