Appendices A

Appendices A. Search Strategy Table A-1. Search strategy for Key Question 1 Search terms Result

"PEP therapy"[tiab] OR "PEP mask"[tiab] OR "Oscillating PEP"[tiab] OR "Chest Wall Oscillation"[mh] 2981 OR "postural drainage"[tiab] OR "Drainage, Postural"[mh] OR ((respiratory[tiab] OR lung[tiab] OR Lung[mh] OR chest[tiab]) AND ("Physical Therapy Modalities"[Mesh:NoExp] OR "physical therapy"[tiab] OR physiotherapy[tiab])) OR "HFCC"[tiab] OR ("high frequency"[tiab] AND chest[tiab] AND (compression[tiab] OR oscillation[tiab])) OR "intrapulmonary percussive ventilation"[tiab] OR Frequencer[tiab] OR "lung flute"[tiab] OR autogenic drainage[tiab] OR ACBT[tiab] OR "active cycle of breathing"[tiab] OR "cough assist"[tiab] OR "cough assistance"[tiab] OR "assisted cough"[tiab] OR "MI-E"[tiab] OR "mechanical insufflation-exsufflation"[tiab] OR "thoracic squeeze"[tiab] ((Positive-Pressure Respiration[mh] OR "positive expiratory pressure"[tiab] OR Flutter[tiab] OR 3696 Quake[tiab] OR Cornet[tiab] OR "RC-Cornet"[tiab] OR Acapella[tiab]OR Percussion[mh] OR percussion[tiab] OR percussing[tiab] OR Vibration[mh] OR vibration[tiab] OR oscillating[tiab] OR oscillation[tiab] OR Sound[mh] OR "sound waves"[tiab] OR Bronchoscopy[mh] OR Suction[mh] OR suction*[tiab] OR IPV[tiab] OR "Breathing Exercises"[mh] OR "non-drug"[tiab] OR "non- pharmacological"[tiab]) AND (Airway Obstruction/therapy[mh] OR "airway clearance"[tiab] OR "airway clearing"[tiab] OR "airway obstruction"[tiab] OR "airflow obstruction"[tiab] OR "lung clearance"[tiab] OR "lung clearing"[tiab] OR "sputum clearance"[tiab] OR "mucus clearance"[tiab] OR "mucous clearance"[tiab] OR "mucous clearing"[tiab] OR "mucociliary clearance"[tiab] OR "respiratory function"[tiab] OR "pulmonary function"[tiab] OR "lung function"[tiab])) (#2 OR #3) AND humans[MeSH] AND English[lang] 4612 #4 limited to 1990 to present 3619 #5 NOT (cystic fibrosis[majr] OR "Sleep Apnea Syndromes"[majr] OR infant, newborn[mh] OR 2857 intensive care units, neonatal[mh] OR newborn[tiab] OR neonatal[tiab]) #6 NOT (editorial[pt] OR letter[pt] OR comment[pt] OR case reports[pt] OR review[pt] OR news[pt] 1771* OR guideline[pt] OR practice guideline[pt] OR historical article[pt] OR jsubsetk)

Table A-2. Search strategy for Key Question 2 Search terms Result (("Neuromuscular Diseases"[mh] OR "Neuromuscular Manifestations"[mh] OR neuromuscular[tiab]) 12201 AND ("Lung"[mh] OR Cough[mh] OR pulmonary[tiab] OR respiratory[tiab] OR Respiration[mh] OR "Work of Breathing"[mh] OR breathing[tiab])) OR "respiratory muscle weakness"[tiab] OR "impaired cough"[tiab] "PEP therapy"[tiab] OR "PEP mask"[tiab] OR "Oscillating PEP"[tiab] OR "Chest Wall Oscillation"[mh] 2981 OR "postural drainage"[tiab] OR "Drainage, Postural"[mh] OR ((respiratory[tiab] OR lung[tiab] OR Lung[mh] OR chest[tiab]) AND ("Physical Therapy Modalities"[Mesh:NoExp] OR "physical therapy"[tiab] OR physiotherapy[tiab])) OR "HFCC"[tiab] OR ("high frequency"[tiab] AND chest[tiab] AND (compression[tiab] OR oscillation[tiab])) OR "intrapulmonary percussive ventilation"[tiab] OR Frequencer[tiab] OR "lung flute"[tiab] OR autogenic drainage[tiab] OR ACBT[tiab] OR "active cycle of breathing"[tiab] OR "cough assist"[tiab] OR "cough assistance"[tiab] OR "assisted cough"[tiab] OR "MI-E"[tiab] OR "mechanical insufflation-exsufflation"[tiab] OR "thoracic squeeze"[tiab]

Appendix-1

Table A-2. Search strategy for Key Question 2, continued Search terms Result ((Positive-Pressure Respiration[mh] OR "positive expiratory pressure"[tiab] OR Flutter[tiab] OR 3696 Quake[tiab] OR Cornet[tiab] OR "RC-Cornet"[tiab] OR Acapella[tiab]OR Percussion[mh] OR percussion[tiab] OR percussing[tiab] OR Vibration[mh] OR vibration[tiab] OR oscillating[tiab] OR oscillation[tiab] OR Sound[mh] OR "sound waves"[tiab] OR Bronchoscopy[mh] OR Suction[mh] OR suction*[tiab] OR IPV[tiab] OR "Breathing Exercises"[mh] OR "non-drug"[tiab] OR "non- pharmacological"[tiab]) AND (Airway Obstruction/therapy[mh] OR "airway clearance"[tiab] OR "airway clearing"[tiab] OR "airway obstruction"[tiab] OR "airflow obstruction"[tiab] OR "lung clearance"[tiab] OR "lung clearing"[tiab] OR "sputum clearance"[tiab] OR "mucus clearance"[tiab] OR "mucous clearance"[tiab] OR "mucous clearing"[tiab] OR "mucociliary clearance"[tiab] OR "respiratory function"[tiab] OR "pulmonary function"[tiab] OR "lung function"[tiab])) #2 AND (#3 OR #4) AND humans[MeSH] AND English[lang] 251 #4 limited to 1990 to present 223 #6 NOT (cystic fibrosis[majr] OR "Sleep Apnea Syndromes"[majr] OR infant, newborn[mh] OR 207 intensive care units, neonatal[mh] OR newborn[tiab] OR neonatal[tiab])

#7 NOT (editorial[pt] OR letter[pt] OR comment[pt] OR case reports[pt] OR review[pt] OR news[pt] 113* OR guideline[pt] OR practice guideline[pt] OR historical article[pt] OR jsubsetk)

Table A-3. Search strategy for Key Question 3 Search terms Result Postoperative Complications[Mesh] OR "Postoperative Care"[Mesh] OR "Postoperative 2867241 Period"[Mesh] OR post-operative[tiab] OR postoperative[tiab] OR post-surgical[tiab] OR postsurgical[tiab] OR "Surgical Procedures, Operative"[Mesh] OR surgery[sh] "PEP therapy"[tiab] OR "PEP mask"[tiab] OR "Oscillating PEP"[tiab] OR "Chest Wall Oscillation"[mh] 2981 OR "postural drainage"[tiab] OR "Drainage, Postural"[mh] OR ((respiratory[tiab] OR lung[tiab] OR Lung[mh] OR chest[tiab]) AND ("Physical Therapy Modalities"[Mesh:NoExp] OR "physical therapy"[tiab] OR physiotherapy[tiab])) OR "HFCC"[tiab] OR ("high frequency"[tiab] AND chest[tiab] AND (compression[tiab] OR oscillation[tiab])) OR "intrapulmonary percussive ventilation"[tiab] OR Frequencer[tiab] OR "lung flute"[tiab] OR autogenic drainage[tiab] OR ACBT[tiab] OR "active cycle of breathing"[tiab] OR "cough assist"[tiab] OR "cough assistance"[tiab] OR "assisted cough"[tiab] OR "MI-E"[tiab] OR "mechanical insufflation-exsufflation"[tiab] OR "thoracic squeeze"[tiab]

((Positive-Pressure Respiration[mh] OR "positive expiratory pressure"[tiab] OR Flutter[tiab] OR 3696 Quake[tiab] OR Cornet[tiab] OR "RC-Cornet"[tiab] OR Acapella[tiab]OR Percussion[mh] OR percussion[tiab] OR percussing[tiab] OR Vibration[mh] OR vibration[tiab] OR oscillating[tiab] OR oscillation[tiab] OR Sound[mh] OR "sound waves"[tiab] OR Bronchoscopy[mh] OR Suction[mh] OR suction*[tiab] OR IPV[tiab] OR "Breathing Exercises"[mh] OR "non-drug"[tiab] OR "non- pharmacological"[tiab]) AND (Airway Obstruction/therapy[mh] OR "airway clearance"[tiab] OR "airway clearing"[tiab] OR "airway obstruction"[tiab] OR "airflow obstruction"[tiab] OR "lung clearance"[tiab] OR "lung clearing"[tiab] OR "sputum clearance"[tiab] OR "mucus clearance"[tiab] OR "mucous clearance"[tiab] OR "mucous clearing"[tiab] OR "mucociliary clearance"[tiab] OR "respiratory function"[tiab] OR "pulmonary function"[tiab] OR "lung function"[tiab])) #2 AND (#3 OR #4) AND humans[MeSH] AND English[lang] 2180 #5 limited to 1990 to present 1723 #6 NOT (cystic fibrosis[majr] OR "Sleep Apnea Syndromes"[majr] OR infant, newborn[mh] OR 1502 intensive care units, neonatal[mh] OR newborn[tiab] OR neonatal[tiab])

#7 NOT (editorial[pt] OR letter[pt] OR comment[pt] OR case reports[pt] OR review[pt] OR news[pt] 844* OR guideline[pt] OR practice guideline[pt] OR historical article[pt] OR jsubsetk)

*Note: There was significant duplication among the results of each search

Appendix-2

B. Review Forms Non-Pharmacologic Airway Clearance Interventions: Abstract Review Form Cannot 1. Original research (exclude editorials, commentaries, letters, narrative reviews) Yes No Determine 2. Includes one of the following: 2a. Hospitalized or postoperative patients over 1 year of age and without cystic Cannot Yes No fibrosis receiving non-pharmacologic Determine airway clearance therapies 2b. Patients with neuromuscular disease or respiratory muscle weakness over 1 Cannot Yes No year of age and without cystic fibrosis and receiving non-pharmacologic airway Determine clearance therapies Cannot 2c. Patients with impaired cough over 1 year of age and without cystic fibrosis and Yes No Determine receiving non-pharmacologic airway clearance therapies

3. Study addresses an intervention used for mucus clearance If yes—circle below: Active cycle of breathing Autogenic drainage Bronchoscopy Cannot Chest physical therapy/physiotherapy (percussion, vibration, positioning, postural Yes No Determine drainage) Cough assist (insufflation/exsufflation, FET, device) Cuirass High frequency chest compression/oscillation vest Intrapulmonary percussive ventilation Positive expiratory pressure (oscillatory PEP, Flutter, Acapella) 4. Study measures effects of intervention on mucus clearance—if yes, circle outcomes below: Time to exacerbation of disease/condition Need for ventilatory assistance ICU or hospital LOS Time to re-admission Number of hospital admissions or hospital days Cannot Quality of life Yes No Determine Pulmonary function (FEV1, FVC, peak flow) Gas exchange Symptoms and signs (dyspnea, cough, HR, ER, breath sounds, retractions) Sputum clearance and expectoration (transport, weight, volume) Exercise tolerance Antibiotic use Harms (including mortality) related to ACT Oxygenation Cannot 5. Setting is hospital or inpatient Yes No Determine Does this study address pharmacologic interventions of interest (i.e., retain for review Cannot for future key questions)? Yes No Determine

Comments:

If excluded, retain for ____Background/Discussion ___Review of references ___Other:

Appendix-3

Non-Pharmacologic Airway Clearance Interventions: Full Text Review Form

1. Original research (exclude editorials, commentaries, letters, narrative reviews) Yes No 2. Includes one of the following: 2a. Hospitalized or postoperative patients over 1 year of age and without cystic fibrosis receiving Yes No nonpharmacologic airway clearance therapies 2b. Patients with neuromuscular disease or respiratory muscle weakness over 1 year of age and without Yes No cystic fibrosis and receiving nonpharmacologic airway clearance therapies 2c. Patients with impaired cough over 1 year of age and without cystic fibrosis and receiving Yes No nonpharmacologic airway clearance therapies 3. Study addresses an intervention used for mucus clearance If yes—circle below: Active cycle of breathing Autogenic drainage Bronchoscopy Yes No Chest physical therapy/physiotherapy (percussion, vibration, positioning, postural drainage) Cough assist (insufflation/exsufflation, FET, device) Cuirass High frequency chest compression/oscillation vest Intrapulmonary percussive ventilation Positive expiratory pressure (oscillatory PEP, Flutter, Acapella)

4. Study includes an intervention and a comparison group Yes No

5. Study measures effects of intervention on mucus clearance—if yes, circle outcomes below: Time to exacerbation of disease/condition Need for ventilatory assistance ICU or hospital LOS Time to re-admission Number of hospital admissions or hospital days Quality of life Yes No Pulmonary function (FEV1, FVC, peak flow) Gas exchange Symptoms and signs (dyspnea, cough, HR, ER, breath sounds, retractions) Sputum clearance and expectoration (transport, weight, volume) Exercise tolerance Antibiotic use Harms (including mortality) related to ACT Oxygenation 6. Setting is hospital or inpatient Yes No Comments:

If excluded, retain for ____Background/Discussion ___Review of references ___Other:

Appendix-4

C. Quality of the Literature

Table C-1. Summary of quality ratings for each study Author, Year Sequence Allocation Selective Other Blinding of Blinding of Incomplete Risk of Bias Generation Concealment Reporting Bias Participants/ Outcome Outcome Rating for Personnel Assessment Data Outcome Studies assessing sputum volume/weight Mahajan et Low Low Low Low Low Low Low Good al., 20111

Chicayban et Low Low Low Low High Low Low Fair al., 20112

Paneroni et Low Unclear Low Low High Low Low Fair al., 20113

Naraparaju et Low High Low Low High High Low Poor al., 20104

Chen et al., Unclear High Low Low High Low Low Poor 20095

Kodric et al., Unclear High High Low High Low Low Poor 20096

Syed et al., Low High Low Low High Low Low Poor 20097

Tsang et al., Low High Low Low High Low Low Poor 20038

Berney et al., High Low Low Low High High Low Poor 20029

Bellone et al., Low High Low Low High High Low Poor 200210

Ambrosino et High High Low Low High High Low Poor al., 199511

Appendix-5

Table C-1. Summary of quality ratings for each study, continued Author, Year Sequence Allocation Selective Other Blinding of Blinding of Incomplete Risk of Bias Generation Concealment Reporting Bias Participants/ Outcome Outcome Rating for Personnel Assessment Data Outcome Studies assessing pulmonary function Mahajan et Low Low Low Low Low Low Low Good al., 20111 Chicayban et Low Low Low Low High Low Low Fair al., 20112 Kodric et al., Unclear High High Low High Low Low Poor 20096 Syed et al., Low High Low Low High Low Low Poor 20097 Haeffener et Low High Low Low High Low High Poor al., 200812 Clini et al., Low High High Unclear Low Low Low Poor 200613 Samransam- Low High Low High High Low Low Poor ruajkit et al., 200314 Tsang et al., Low High Low Low High Low Low Poor 20038 Denehy et al., High Low Low Low High Low High Poor 200115

Ntoumeno- High Low Low Low Low Low Low Fair poulos et al., 199816 Olsen et al., High High Low Low High Low Low Poor 199717

Johnson et al., High High Low Low High Low Low Poor 199618

Johnson et al., High High Low Low High Low Low Poor 199519

Ambrosino et High High Low Low High Low Low poor al., 199511

Asher et al., Low High Low Low High Low Low Fair 199020

Appendix-6

Paneroni et Low Unclear Low Low Low Low Low Good al., 20113

Kodric et al., Unclear High High Low High Low Low Poor 20096

DiDario et al., High High Low High Low Low Low Poor 200921

Samransam- Low High Low High Low Low Low Fair ruajkitet al., 200314 Denehy et al., High Low Low Low Low Low Low Fair 200115

Olsen et al., High High Low Low Low Low Low Poor 199717

Vargas et al., Unclear Low Low Low Low Low Low Fair 200522

Studies assessing gas exchange Chicayban et Low Low Low Low Low Low High Fair al., 20112

Antonaglia et Low High Low Low Low Low Low Fair al., 200623

Clini et al., Low High High Unclear Low Low Low Poor 200613

Unoki et al., High High Low Unclear Low Low Low Poor 200524

Vargas et al., Unclear Low Low Low Low Low Low Fair 200522

Barker et al., High Low Low Low Low Low Low Fair 200225

Appendix-7

Table C-1. Summary of quality ratings for each study, continued Author, Year Sequence Allocation Selective Other Blinding of Blinding of Incomplete Risk of Bias Generation Concealment Reporting Bias Participants/ Outcome Outcome Rating for Personnel Assessment Data Outcome Studies assessing gas exchange deCharmoy et High High Low High Low Low Low Poor al., 200026 Krause et al., Low High Low Low Low Low Low Fair 200027 Ambrosino et High High Low Low Low Low Low Poor al., 199511 Studies assessing length of stay Cross et al., Low High Low Low Low Low Low Fair 201028 Kodric et al., Unclear High High Low Low Low Low Poor 20096 Haeffener et Low High Low Low Low Low High Poor al., 200812 Paludo et al., Low High Low Low Low Low Low Fair 200829 Templeton et Unclear High Low Low Low Low Low Fair al., 200730 Antonaglia et Low High Low Low Low Low Low Fair al., 200623 Vargas et al., Unclear Low Low Low Low Low Low Fair 200522

Mackay et al., Low Low Low Low Low Low Low Good 200531 Samransam- Low High Low High Low Low Low Fair ruajkit et al., 200314 Tsang et al., Low High Low Low Low Low Low Fair 20038 Denehy et al., High Low Low Low Low Low Low Fair 200115

Appendix-8

Johnson et al., High High Low Low Low Low Low Poor 199618

Johnson et al., High High Low Low Low Low Low Poor 199519

Asher et al., Low High Low Low Low Low Low Fair 199020

Studies assessing dyspnea Mahajan et Low Low Low Low Low Low Low Good al., 20111

Cross et al., Low High Low Low High Low Low Poor 201028

Kodric et al., Unclear High High Low High High High Poor 20096

Paneroni et Low Unclear Low Low High High Low Poor al., 20113

Studies assessing MAP Chicayban et Low Low Low Low Low Low Low Good al., 20112

Barker et al., High Low Low Low Low Low Low Fair 200225

Antonaglia et Low High Low Low Low Low Low Fair al., 200623

Appendix-9

Paludo et al., Low High Low Low Low Low Low Fair 200829

Vargas et al., Unclear Low Low Low High High Low Poor 200522

Antonaglia et Low High Low Low High High Low Poor al., 200623

Studies assessing heart rate Chicayban et Low Low Low Low High Low Low Fair al., 20112

Paneroni et Low Unclear Low Low High High Low Poor al., 20113

Barker et al., High Low Low Low High Low Low Poor 200225

Johnson et al., High High Low Low High High Low Poor 199618

Antonaglia et Low High Low Low High High Low poor al., 200623

Studies assessing hospital readmission (time to exacerbation) Mahajan et Low Low Low Low Low Low Low Good al., 20111

Cross et al., Low High Low Low Low Low Low Fair 201028

Kodric et al., Unclear High High Low High Low Low Poor 20096

Appendix-10

Cross et al., Low High Low Low Low Low Low Fair 201028

Studies assessing QOL Cross et al., Low High Low Low High High Low Poor 201028

Kodric et al., Unclear High High Low High High High Poor 20096

Studies assessing exercise tolerance Cross et al., Low High Low Low High Low High Poor 201028

Haeffener et Low High Low Low High Low High Poor al., 200812

Studies assessing duration of ventilation Templeton et Unclear High Low Low Low Low Low Fair al., 200730

Antonaglia et Low High Low Low Low Low Low Fair al., 200623

Bellone et al., Low High Low Low Low Low Low Fair 200210

Ntoumeno- High Low Low Low Low Low Low Fair poulos et al., 199816

Appendix-11

Antonaglia et Low High Low Low Low Low Low Fair al., 200623

Vargas et al., Unclear Low Low Low Low Low Low Fair 200522

Mackay et al., Low Low Low Low Low Low Low Good 200531

Studies assessing pulmonary complications Antonaglia et Low High Low Low Low Low Low Fair al., 200623

Mackay et al., Low Low Low Low Low Low Low Good 200531

Berney et al., High Low Low Low Low High Low Poor 20029

Denehy et al., High Low Low Low Low Low Low Fair 200115

Olsen et al., High High Low Low Low High Low Poor 199717

Johnson et al., High High Low Low Low Low Low poor 199618

Johnson et al., High High Low Low Low Low Low Poor 199519 Note: Ntoumenopoulos et al., 200232 was assessed using the Newcastle-Ottawa scale for cohort studies, which does not rate risk of bias for each outcome. We rated the study as good quality(representative cohort; non-exposed cohort drawn from same community as exposed cohort; secure record used for ascertainment of exposure; demonstration that outcome was not present at start of study; study controlled for age and other factors; blinded, independent outcome assessment; adequate followup)

Appendix-12

Table C-2. Quality of studies by outcome Study Outcome/Quality

Tolerance

Pulmonary Function Pulmonary Exchange Gas Oxygenation Rate Heart MAP Dyspnea Rate Respiratory Exercise Sputum Weight/Volume QOL or (Hospital LOS ICU) Ventilation For Need of Duration Ventilation Pulmonary Complications Re Hospital To Admission/Time Exacerbation ACT of Harms Chicayaban et al., Fair Fair Good Good Fair 20112 Mahajan et al., Good Good Good Good Good 20111 Paneroni et al., Good Poor Poor Poor Fair Poor 20113 Cross et al., Poor Poor Poor Fair Fair Fair 201028 Naraparaju et al., Poor 20104 Chen et al., 20095 Poor DiDario et al., Poor 200921 Kodric et al., Poor Poor Poor Poor Poor Poor Poor 20096 Syed et al., 20097 Poor Poor Haeffener et al., Poor Poor Poor 200812 Paludo et al., Fair* Fair* Fair 200829 Templeton et al., Fair Fair Fair 200730 Antonaglia et al., Fair Poor Fair Poor Fair Fair Fair Fair 200623 Clini et al., 200613 Poor Poor Mackay et al., Good Good Good Good 200531 Unoki et al., Poor 200524 Vargas et al., Fair Fair Poor Fair Fair 200522

Table C-2. Quality of studies by outcome, continued

Appendix-13

Study Outcome/Quality

Pulmonary Function Pulmonary Exchange Gas Oxygenation Rate Heart MAP Dyspnea Rate Respiratory Tolerance Exercise Sputum Weight/Volume QOL or (Hospital LOS ICU) Ventilation For Need of Duration Ventilation Pulmonary Complications Re Hospital To Admission/Time Exacerbation ACT of Harms Samransamruajkit Poor Fair Fair et al., 200314 Tsang et al., Poor Poor Fair 20038 Barker et al., Fair Poor Poor 200225 Bellone et al., Poor Fair 200210 Berney et al., Poor Poor 20029 Denehy et al., Poor Fair Fair Fair 200115 deCharmoy et al., Poor Poor 200026 Krause et al., Fair 200027 Ntoumenopoulos Fair Fair et al., 199816 Olsen et al., Poor Poor Poor Poor 199717 Johnson et al., Poor Poor Poor Poor 199618 Ambrosino et al., Poor Poor Poor 199511 Johnson et al., Poor Poor Poor 199519 Asher et al., Fair 199020 *Time to normal oxygen saturation and respiratory rate. ACT=airway clearance therapies; LOS=length of stay; MAP=mean arterial pressure; QOL=quality of life.

Appendix-14

D. Excluded Studies

Reasons for Exclusion

X-1 Not original research X-2 Did not include eligible population X-3 Did not include eligible intervention(s) X-4 Did not include eligible outcomes X-5 Not conducted in hospital/inpatient setting X-6 Did not include appropriate comparison group or ineligible study design X-7 Not in English or unable to obtain X-8 Systematic review used as reference source/background material

Appendix-15

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Appendix-16

22. Aksoy EA, Elsurer C, Serin GM, et al. Evaluation of 33. Maricevic A, Erceg M, Gulan G, et al. Complications after pediatric subglottic cysts. Int J Pediatr Otorhinolaryngol. 2012 hip rearthroplastics with revision endoprosthesis. Coll Antropol. Feb;76(2):240-3. PMID: 22172219. X-2, X-3, X-4 2011 Sep;35(3):867-71. PMID: 22053569. X-2, X-3, X-4

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31. Rief H, Jensen AD, Bruckner T, et al. Isometric muscle 43. Alcoforado L, Pessoa Filho LC, Brandao DC, et al. training of the spine musculature in patients with spinal bony Influence of change in lateral decubitus on pulmonary aerosol metastases under radiation therapy. BMC Cancer. 2011;11:482. deposition. Rev Bras Fisioter. 2011 Aug-Sep;15(4):278-83. PMID: 22070722. X-2, X-3, X-4 PMID: 21971723. X-2, X-3, X-4, X-5

32. Higginson R, Jones B, Davies K. Emergency and intensive 44. Nery FP, Lopes AJ, Domingos DN, et al. CPAP increases 6- care: assessing and managing the airway. Br J Nurs. 2011 Sep 8- minute walk distance after lung resection surgery. Respir Care. 22;20(16):970, 2, 4 passim. PMID: 22067489. X-2, X-3, X-4 2012 Mar;57(3):363-9. PMID: 21968296. X-2, X-3, X-4

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45. Kanazawa H, Tochino Y, Asai K, et al. Validity of HMGB1 rehabilitation in chronic obstructive pulmonary disease patients: measurement in epithelial lining fluid in patients with COPD. a randomized controlled trial. Respir Res. 2011;12:112. PMID: Eur J Clin Invest. 2012 Apr;42(4):419-26. PMID: 21950682. X- 21861914. X-2, X-3, X-4, X-5, X-6 2, X-3, X-4, X-5 56. Mahut B, Plantier L, Malinvaud D, et al. Pathophysiology of 46. Fehniger TE, Vegvari A, Rezeli M, et al. Direct airway hyperresponsiveness in patients with nasal polyposis. demonstration of tissue uptake of an inhaled drug: proof-of- Respir Med. 2012 Jan;106(1):68-74. PMID: 21855311. X-2, X- principle study using matrix-assisted laser desorption ionization 3, X-4 mass spectrometry imaging. Anal Chem. 2011 Nov 1;83(21):8329-36. PMID: 21942412. X-2, X-3, X-4 57. Good JT, Jr., Kolakowski CA, Groshong SD, et al. Refractory asthma: importance of bronchoscopy to identify 47. Westerdahl E, Olsen MF. Chest physiotherapy and breathing phenotypes and direct therapy. Chest. 2012 Mar;141(3):599- exercises for cardiac surgery patients in Sweden--a national 606. PMID: 21835905. X-3, X-4 survey of practice. Monaldi Arch Chest Dis. 2011 Jun;75(2):112-9. PMID: 21932695. X-1, X-2, X-4 58. Shiratsuchi N, Asai K, Kanazawa H, et al. Measurement of soluble perforin, a marker of CD8+ T lymphocyte activation in 48. Chen S, Su CL, Wu YT, et al. Physical training is beneficial epithelial lining fluid. Respir Med. 2011 Dec;105(12):1885-90. to functional status and survival in patients with prolonged PMID: 21827966. X-3, X-4 mechanical ventilation. J Formos Med Assoc. 2011 Sep;110(9):572-9. PMID: 21930067. X-3, X-4 59. Kardos P, Wittchen HU, Muhlig S, et al. Controlled and uncontrolled allergic asthma in routine respiratory specialist care 49. Herbst-Rodrigues MV, Carvalho VO, Auler JO, Jr., et al. - a clinical-epidemiological study in Germany. Curr Med Res PEEP-ZEEP technique: cardiorespiratory repercussions in Opin. 2011 Sep;27(9):1835-47. PMID: 21824036. X-3, X-4, X-5 mechanically ventilated patients submitted to a coronary artery bypass graft surgery. J Cardiothorac Surg. 2011;6:108. PMID: 60. Kermode JA, Brown NJ, Hardaker KM, et al. The effect of 21914178. X-3, X-6 airway remodelling on airway hyper-responsiveness in asthma. Respir Med. 2011 Dec;105(12):1798-804. PMID: 21820298. X- 50. Komasawa N, Ueki R, Kohama H, et al. Comparison of 3, X-5 Pentax-AWS Airwayscope video laryngoscope, Airtraq optic laryngoscope, and Macintosh laryngoscope during 61. Lopes AJ, Capone D, Mogami R, et al. Severity cardiopulmonary resuscitation under cervical stabilization: a classification for idiopathic pulmonary fibrosis by using fuzzy manikin study. J Anesth. 2011 Dec;25(6):898-903. PMID: logic. Clinics (Sao Paulo). 2011;66(6):1015-9. PMID: 21901329. X-2, X-3, X-4 21808868. X-2, X-3, X-4

51. Morrison MP, Meiler S, Postma GN. Ventilatory techniques 62. Guerin C, Bourdin G, Leray V, et al. Performance of the for central airway obstruction. Laryngoscope. 2011 coughassist insufflation-exsufflation device in the presence of an Oct;121(10):2162-4. PMID: 21898425. X-2, X-3, X-4, X-5, X-6 endotracheal tube or tracheostomy tube: a bench study. Respir Care. 2011 Aug;56(8):1108-14. PMID: 21801577. X-2, X-4, X- 52. Pehlivan E, Turna A, Gurses A, et al. The effects of 5, X-6 preoperative short-term intense physical therapy in lung cancer patients: a randomized controlled trial. Ann Thorac Cardiovasc 63. Hermes A, Heigener D, Gatzemeier U, et al. Efficacy and Surg. 2011;17(5):461-8. PMID: 21881371. X-2, X-3, X-4 safety of bronchoscopic laser therapy in patients with tracheal and bronchial obstruction: a retrospective single institution 53. Gomieiro LT, Nascimento A, Tanno LK, et al. Respiratory report. Clin Respir J. 2012 Apr;6(2):67-71. PMID: 21801329. exercise program for elderly individuals with asthma. Clinics X-2, X-3, X-4 (Sao Paulo). 2011;66(7):1163-9. PMID: 21876968. X-2, X-3, X- 4, X-5, X-6 64. Savci S, Degirmenci B, Saglam M, et al. Short-term effects of inspiratory muscle training in coronary artery bypass graft 54. Mendivil CO, Teeter JG, Finch GL, et al. Trough insulin surgery: a randomized controlled trial. Scand Cardiovasc J. 2011 levels in bronchoalveolar lavage following inhaled human Oct;45(5):286-93. PMID: 21793631. X-3, X-4 insulin (Exubera) in patients with diabetes mellitus. Diabetes Technol Ther. 2012 Jan;14(1):50-8. PMID: 21875362. X-2, X-3, 65. Wahidi MM, Unroe MA, Adlakha N, et al. The use of X-4 electrocautery as the primary ablation modality for malignant and benign airway obstruction. J Thorac Oncol. 2011 55. Duiverman ML, Wempe JB, Bladder G, et al. Two-year Sep;6(9):1516-20. PMID: 21792075. X-2, X-3, X-4 home-based nocturnal noninvasive ventilation added to

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70. O'Clock GD, Lee YW, Lee J, et al. High-frequency and low- 80. Lewis C, Souvlis T, Sterling M. Strain-Counterstrain therapy frequency chest compression: effects on lung water secretion, combined with exercise is not more effective than exercise alone mucus transport, heart rate, and blood pressure using a on pain and disability in people with acute low back pain: a trapezoidal source pressure waveform. IEEE Trans Biomed Eng. randomised trial. J Physiother. 2011;57(2):91-8. PMID: 2012 Jan;59(1):106-14. PMID: 21775255. X-4 21684490. X-2, X-3, X-4, X-5

71. Schumann S, Messmer F, Lichtwarck-Aschoff M, et al. 81. Lanza FC, Wandalsen G, Dela Bianca AC, et al. Prolonged Cardiogenic oscillations in spontaneous breathing airway signal slow expiration technique in infants: effects on tidal volume, reflect respiratory system mechanics. Acta Anaesthesiol Scand. peak expiratory flow, and expiratory reserve volume. Respir 2011 Sep;55(8):980-6. PMID: 21770903. X-2, X-3, X-4 Care. 2011 Dec;56(12):1930-5. PMID: 21682953. X-2, X-4

72. Adhikari NK, Bashir A, Lamontagne F, et al. High- 82. Becker DE, Haas DA. Recognition and management of frequency oscillation in adults: a utilization review. Crit Care complications during moderate and deep sedation part 1: Med. 2011 Dec;39(12):2631-44. PMID: 21765359. X-2, X-3, X- respiratory considerations. Anesth Prog. 2011 4 Summer;58(2):82-92. PMID: 21679044. X-1

73. Turner DA, Cheifetz IM, Rehder KJ, et al. Active 83. Grammatopoulou EP, Skordilis EK, Stavrou N, et al. The rehabilitation and physical therapy during extracorporeal effect of physiotherapy-based breathing retraining on asthma membrane oxygenation while awaiting lung transplantation: a control. J Asthma. 2011 Aug;48(6):593-601. PMID: 21668321. practical approach. Crit Care Med. 2011 Dec;39(12):2593-8. X-2, X-3, X-4, X-5 PMID: 21765353. X-1, X-3, X-4 84. Dimassi S, Vargas F, Lyazidi A, et al. Intrapulmonary 74. Clinkscale D, Spihlman K, Watts P, et al. A randomized trial percussive ventilation superimposed on spontaneous breathing: a of conventional chest physical therapy versus high frequency physiological study in patients at risk for extubation failure. chest wall compressions in intubated and non-intubated adults. Intensive Care Med. 2011 Aug;37(8):1269-76. PMID: Respir Care. 2012 Feb;57(2):221-8. PMID: 21762564. X-2 21656293. X-6

75. Wronka KS, Salama H, Ramesh B. Management of 85. Sutton RM, Niles D, Meaney PA, et al. Low-dose, high- displaced ankle fractures in elderly patients--is it worth frequency CPR training improves skill retention of in-hospital performing osteosynthesis of osteoporotic bone? Ortop pediatric providers. Pediatrics. 2011 Jul;128(1):e145-51. PMID: Traumatol Rehabil. 2011 May-Jun;13(3):293-8. PMID: 21646262. X-2, X-3, X-4, X-5 21750359. X-2, X-3, X-4, X-5 86. Tambascio J, de Souza LT, Lisboa RM, et al. The influence 76. Jeschke E, Ostermann T, Tabali M, et al. Anthroposophic of Flutter(R)VRP1 components on mucus transport of patients medicine in pediatric primary care: a prospective, multicenter with bronchiectasis. Respir Med. 2011 Sep;105(9):1316-21. observational study on prescribing patterns. Altern Ther Health PMID: 21641196. X-2, X-4, X-5

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129. Lessa FA, Paes CD, Tonella RM, et al. Comparison of the controlled study. Clin Rehabil. 2011 Jun;25(6):524-36. PMID: rapid shallow breathing index (RSBI) calculated under direct 21285287. X-3, X-5 and indirect form on the postoperative period of cardiac surgery. Rev Bras Fisioter. 2010 Nov-Dec;14(6):503-9. PMID: 140. Chan JG, Kwok PC, Young PM, et al. Mannitol delivery by 21340245. X-3, X-4 vibrating mesh nebulisation for enhancing mucociliary clearance. J Pharm Sci. 2011 Jul;100(7):2693-702. PMID: 130. Faria AC, Costa AA, Lopes AJ, et al. Forced oscillation 21283985. X-3, X-4 technique in the detection of smoking-induced respiratory alterations: diagnostic accuracy and comparison with 141. Sirithangkul S, Ranganathan S, Robinson PJ, et al. Positive spirometry. Clinics (Sao Paulo). 2010;65(12):1295-304. PMID: expiratory pressure to enhance cough effectiveness in 21340218. X-3, X-4 tracheomalacia. J Med Assoc Thai. 2010 Nov;93 Suppl 6:S112- 8. PMID: 21280523. X-5 131. Heinze H, Eichler W, Karsten J, et al. Functional residual capacity-guided alveolar recruitment strategy after endotracheal 142. Thistlethwaite PA, Renner J, Duhamel D, et al. Surgical suctioning in cardiac surgery patients. Crit Care Med. 2011 management of endobronchial inflammatory myofibroblastic May;39(5):1042-9. PMID: 21336125. X-2, X-3, X-4 tumors. Ann Thorac Surg. 2011 Feb;91(2):367-72. PMID: 21256271. X-2, X-3, X-4 132. Mitterlechner T, Wipp A, Herff H, et al. A comparison of the suction laryngoscope and the Macintosh laryngoscope in 143. Khan MA, Dar AM, Kawoosa NU, et al. Clinical profile emergency medical technicians: a manikin model of severe and surgical outcome for pulmonary aspergilloma: nine year airway haemorrhage. Emerg Med J. 2012 Jan;29(1):54-5. PMID: retrospective observational study in a tertiary care hospital. Int J 21335576. X-2, X-3, X-4, X-5 Surg. 2011;9(3):267-71. PMID: 21252003. X-2, X-3, X-4

133. Lischke R, Pozniak J, Vondrys D, et al. Novel 144. Haley KB, Lerner EB, Pirrallo RG, et al. The frequency biodegradable stents in the treatment of bronchial stenosis after and consequences of cardiopulmonary resuscitation performed lung transplantation. Eur J Cardiothorac Surg. 2011 by bystanders on patients who are not in cardiac arrest. Prehosp Sep;40(3):619-24. PMID: 21334911. X-2, X-3, X-4, X-5 Emerg Care. 2011 Apr-Jun;15(2):282-7. PMID: 21250928. X-2, X-3, X-4, X-5 134. Bach JR, Martinez D. Duchenne muscular dystrophy: continuous noninvasive ventilatory support prolongs survival. 145. Kesiktas N, Karagulle Z, Erdogan N, et al. The efficacy of Respir Care. 2011 Jun;56(6):744-50. PMID: 21333078. X-5, X- balneotherapy and physical modalities on the pulmonary system 6 of patients with fibromyalgia. J Back Musculoskelet Rehabil. 2011;24(1):57-65. PMID: 21248401. X-2, X-3, X-4, X-5 135. Shomaker KL, Weiner T, Esther CR, Jr. Impact of an evidence-based algorithm on quality of care in pediatric 146. Casali CC, Pereira AP, Martinez JA, et al. Effects of parapneumonic effusion and empyema. Pediatr Pulmonol. 2011 inspiratory muscle training on muscular and pulmonary function Jul;46(7):722-8. PMID: 21328575. X-2, X-3, X-4 after bariatric surgery in obese patients. Obes Surg. 2011 Sep;21(9):1389-94. PMID: 21229331. X-2, X-3, X-4 136. Shaw BS, Shaw I. Pulmonary function and abdominal and thoracic kinematic changes following aerobic and inspiratory 147. Novoa N, Ballesteros E, Jimenez MF, et al. Chest resistive diaphragmatic breathing training in asthmatics. Lung. physiotherapy revisited: evaluation of its influence on the 2011 Apr;189(2):131-9. PMID: 21318637. X-3, X-5 pulmonary morbidity after pulmonary resection. Eur J Cardiothorac Surg. 2011 Jul;40(1):130-4. PMID: 21227711. X-2 137. Charokopos N, Foroulis CN, Rouska E, et al. The management of post-intubation tracheal stenoses with self- 148. Yamaguti WP, Sakamoto ET, Panazzolo D, et al. expandable stents: early and long-term results in 11 cases. Eur J Diaphragmatic mobility in healthy subjects during incentive Cardiothorac Surg. 2011 Oct;40(4):919-24. PMID: 21316981. spirometry with a flow-oriented device and with a volume- X-2, X-3, X-4, X-6 oriented device. J Bras Pneumol. 2010 Nov-Dec;36(6):738-45. PMID: 21225177. X-2, X-3, X-4, X-5 138. Thomson NC, Rubin AS, Niven RM, et al. Long-term (5 year) safety of bronchial thermoplasty: Asthma Intervention 149. Shah PL, Slebos DJ, Cardoso PF, et al. Design of the Research (AIR) trial. BMC Pulm Med. 2011;11:8. PMID: exhale airway stents for emphysema (EASE) trial: an 21314924. X-2, X-3, X-4, X-5 endoscopic procedure for reducing hyperinflation. BMC Pulm Med. 2011;11:1. PMID: 21214899. X-3 139. Liaw MY, Wang YH, Tsai YC, et al. Inspiratory muscle training in bronchiectasis patients: a prospective randomized

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150. Correa AP, Ribeiro JP, Balzan FM, et al. Inspiratory Neuromuscul Disord. 2011 Jan;21(1):47-51. PMID: 21144751. muscle training in type 2 diabetes with inspiratory muscle X-5 weakness. Med Sci Sports Exerc. 2011 Jul;43(7):1135-41. PMID: 21200342. X-2, X-3, X-5 162. Hwang YJ, Kolettis N, Yang M, et al. Multiphoton imaging of actin filament formation and mitochondrial energetics of 151. Malmstrom K, Pelkonen AS, Malmberg LP, et al. Lung human ACBT gliomas. Photochem Photobiol. 2011 Mar- function, airway remodelling and inflammation in symptomatic Apr;87(2):408-17. PMID: 21143483. X-2, X-3, X-4, X-5 infants: outcome at 3 years. Thorax. 2011 Feb;66(2):157-62. PMID: 21199817. X-3, X-5 163. Dennis DM, Jacob WJ, Samuel FD. A survey of the use of ventilator hyperinflation in Australian tertiary intensive care 152. Varela G, Novoa NM, Agostini P, et al. Chest units. Crit Care Resusc. 2010 Dec;12(4):262-8. PMID: physiotherapy in lung resection patients: state of the art. Semin 21143087. X-2, X-3, X-4, X-5, X-6 Thorac Cardiovasc Surg. 2011 Winter;23(4):297-306. PMID: 22443649. X-1 164. Deng J, Zheng Y, Li C, et al. Plastic bronchitis in three children associated with 2009 influenza A(H1N1) virus 153. Figueiredo PH, Zin WA, Guimaraes FS. Flutter valve infection. Chest. 2010 Dec;138(6):1486-8. PMID: 21138885. X- improves respiratory mechanics and sputum production in 1, X-4, X-6 patients with bronchiectasis. Physiother Res Int. 2012 Mar;17(1):12-20. PMID: 21182171. X-5 165. Noe KH, Tapsell LM, Drazkowski JF. Risk of choking and aspiration during inpatient video-EEG monitoring. Epilepsy Res. 154. Hamaekers AE, Borg PA, Gotz T, et al. Ventilation through 2011 Jan;93(1):84-6. PMID: 21123032. X-2, X-3, X-4 a small-bore catheter: optimizing expiratory ventilation assistance. Br J Anaesth. 2011 Mar;106(3):403-9. PMID: 166. Fernandez-Cadenas I, Mendioroz M, Domingues- 21177698. X-2, X-3, X-4, X-5 Montanari S, et al. Leukoaraiosis is associated with genes regulating blood-brain barrier homeostasis in ischaemic stroke 155. Swanson SJ. Segmentectomy for lung cancer. Semin patients. Eur J Neurol. 2011 Jun;18(6):826-35. PMID: Thorac Cardiovasc Surg. 2010 Autumn;22(3):244-9. PMID: 21122033. X-2, X-3, X-4, X-5 21167459. X-2, X-3, X-4, X-6 167. Ebell MH. Chest physiotherapy for pneumonia in adults. 156. Oscroft NS, Ali M, Gulati A, et al. A randomised crossover Am Fam Physician. 2010 Dec 1;82(11):1340. PMID: 21121517. trial comparing volume assured and pressure preset noninvasive X-1, X-2, X-3, X-4, X-5, X-6 ventilation in stable hypercapnic COPD. COPD. 2010 Dec;7(6):398-403. PMID: 21166627. X-2, X-3, X-5 168. Braund R, Abbott JH. Recommending NSAIDs and paracetamol: A survey of New Zealand physiotherapists' 157. Chadwick JR. Prone positioning in trauma patients: nursing knowledge and behaviours. Physiother Res Int. 2011 roles and responsibilities. J Trauma Nurs. 2010 Oct- Mar;16(1):43-9. PMID: 21110412. X-2, X-3, X-4, X-5 Dec;17(4):201-7; quiz 8-9. PMID: 21157253. X-1 169. Alves CE, Nunes LQ, Melo PL. Mechanical analysis of an 158. Oviatt PL, Stather DR, Michaud G, et al. Exercise capacity, oscillatory positive expiratory pressure device used in lung function, and quality of life after interventional respiratory rehabilitation. Conf Proc IEEE Eng Med Biol Soc. bronchoscopy. J Thorac Oncol. 2011 Jan;6(1):38-42. PMID: 2010;2010:2477-80. PMID: 21096164. X-1, X-2, X-3, X-4, X-5, 21150471. X-2, X-3, X-4, X-5 X-6

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215. Tsolaki V, Pastaka C, Kostikas K, et al. Noninvasive Arch Phys Med Rehabil. 2010 Jun;91(6):857-61. PMID: ventilation in chronic respiratory failure: effects on quality of 20510974. X-3, X-4 life. Respiration. 2011;81(5):402-10. PMID: 20588002. X-2, X- 3, X-5 226. Fiore JF, Chiavegato LD, Paisani DM, et al. Utilization of positive-pressure devices for breathing exercises in the hospital 216. Harding KE, Taylor NF, Leggat SG, et al. Prioritizing setting: a regional survey in Sao Paulo, Brazil. Respir Care. patients for Community Rehabilitation Services: do clinicians 2010 Jun;55(6):719-24. PMID: 20507654. X-1 agree on triage decisions? Clin Rehabil. 2010 Oct;24(10):928- 34. PMID: 20576668. X-1, X-2, X-3, X-4, X-5 227. Kauffman P, Wolosker N, de Campos JR, et al. Azygos lobe: a difficulty in video-assisted thoracic sympathectomy. Ann 217. Rodriguez ME, Mackenzie WG, Ditro C, et al. Skeletal Thorac Surg. 2010 Jun;89(6):e57-9. PMID: 20494015. X-1 dysplasias: evaluation with impulse oscillometry and thoracoabdominal motion analysis. Pediatr Pulmonol. 2010 228. Crew JD, Svircev JN, Burns SP. Mechanical insufflation- Jul;45(7):679-86. PMID: 20575094. X-1 exsufflation device prescription for outpatients with tetraplegia. J Spinal Cord Med. 2010;33(2):128-34. PMID: 20486531. X-5 218. Chatwin M, Bush A, Simonds AK. Outcome of goal- directed non-invasive ventilation and mechanical 229. Alloubi I, Jougon J, Delcambre F, et al. Early insufflation/exsufflation in spinal muscular atrophy type I. Arch complications after pneumonectomy: retrospective study of 168 Dis Child. 2011 May;96(5):426-32. PMID: 20573738. X-3 patients. Interact Cardiovasc Thorac Surg. 2010 Aug;11(2):162- 5. PMID: 20472651. X-1 219. Niggemann P, Kuchta J, Grosskurth D, et al. Position dependent changes of the cerebral venous drainage--implications 230. Verbanck S, de Keukeleire T, Schuermans D, et al. for the imaging of the cervical spine. Cent Eur Neurosurg. 2011 Detecting upper airway obstruction in patients with tracheal Feb;72(1):32-7. PMID: 20552542. X-1 stenosis. J Appl Physiol. 2010 Jul;109(1):47-52. PMID: 20466805. X-1, X-3, X-4 220. Babu AS, Noone MS, Haneef M, et al. The effects of 'on- call/out of hours' physical therapy in acute exacerbations of 231. Kobayashi M, Fujiwara A, Morita H, et al. Verification of chronic obstructive pulmonary disease: a randomized controlled airway management during cardiac arrest: a manikin-based trial. Clin Rehabil. 2010 Sep;24(9):802-9. PMID: 20543018. X- observational study. Am J Emerg Med. 2010 May;28(4):499- 6 504. PMID: 20466233. X-2, X-3, X-4, X-5

221. Seppa VP, Viik J, Hyttinen J. Assessment of pulmonary 232. Dick T. Finger-saver paramedic invents answer to real urp. flow using impedance pneumography. IEEE Trans Biomed Eng. JEMS. 2010 May;35(5):34. PMID: 20451053. X-1 2010 Sep;57(9):2277-85. PMID: 20542759. X-1, X-2, X-3, X-4, X-5 233. Goodridge D, Lawson J, Rennie D, et al. Rural/urban differences in health care utilization and place of death for 222. Heuer AJ, Geisler S, Kamienski M, et al. Introducing persons with respiratory illness in the last year of life. Rural medical students to the interdisciplinary health care team: Remote Health. 2010 Apr-Jun;10(2):1349. PMID: 20438281. X- piloting a case-based approach. J Allied Health. 2010 1 Summer;39(2):76-81. PMID: 20539929. X-1, X-2, X-3, X-4, X- 5 234. McMillan HJ, Campbell C, Mah JK. Duchenne muscular dystrophy: Canadian paediatric neuromuscular physicians 223. Senduran M, Yurdalan SU, Karadibak D, et al. survey. Can J Neurol Sci. 2010 Mar;37(2):195-205. PMID: Haemodynamic effects of physiotherapy programme in intensive 20437929. X-1 care unit after liver transplantation. Disabil Rehabil. 2010;32(17):1461-6. PMID: 20533874. X-1 235. Scala R, Naldi M, Maccari U. Early fiberoptic bronchoscopy during non-invasive ventilation in patients with 224. Scherer T, Geller DE, Owyang L, et al. A technical decompensated chronic obstructive pulmonary disease due to feasibility study of dornase alfa delivery with eFlow(R) community-acquired-pneumonia. Crit Care. 2010;14(2):R80. vibrating membrane nebulizers: aerosol characteristics and PMID: 20429929. X-3, X-4, X-6 physicochemical stability. J Pharm Sci. 2011 Jan;100(1):98-109. PMID: 20533437. X-1 236. Ferreira GM, Haeffner MP, Barreto SS, et al. [Incentive spirometry with expiratory positive airway pressure brings 225. Roth EJ, Stenson KW, Powley S, et al. Expiratory muscle benefits after myocardial revascularization]. Arq Bras Cardiol. training in spinal cord injury: a randomized controlled trial. 2010 Feb;94(2):230-5, 46-51, 3-8. PMID: 20428621. X-3, X-4, X-5

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237. Terragni PP, Birocco A, Faggiano C, et al. Extracorporeal patients with cerebral palsy and neuromuscular diseases: an CO2 removal. Contrib Nephrol. 2010;165:185-96. PMID: exploratory randomized controlled trial. J Child Neurol. 2010 20427969. X-1 Jul;25(7):815-21. PMID: 20357238. X-5

238. Franke KJ, Nilius G, Morgenstern S, et al. Removal of the 249. Fujii M, Miyagi Y, Bessho R, et al. Effect of a neutrophil tracheal tube after prolonged mechanical ventilation: assessment elastase inhibitor on acute lung injury after cardiopulmonary of risk by oscillatory impedance. Respiration. 2011;81(2):118- bypass. Interact Cardiovasc Thorac Surg. 2010 Jun;10(6):859- 23. PMID: 20424425. X-1 62. PMID: 20354035. X-2, X-3, X-4

239. Anaf S, Sheppard LA. Lost in translation? How patients 250. Shields N, Taylor NF, Fernhall B. A study protocol of a perceive the extended scope of physiotherapy in the emergency randomised controlled trial to investigate if a community based department. Physiotherapy. 2010 Jun;96(2):160-8. PMID: strength training programme improves work task performance in 20420963. X-1 young adults with Down syndrome. BMC Pediatr. 2010;10:17. PMID: 20334692. X-3, X-4, X-5 240. Gupta D, Nath A, Agarwal R, et al. A prospective randomized controlled trial on the efficacy of noninvasive 251. Chung FT, Lin SM, Chou CL, et al. Factors leading to ventilation in severe acute asthma. Respir Care. 2010 obstructive granulation tissue formation after ultraflex stenting May;55(5):536-43. PMID: 20420722. X-3 in benign tracheal narrowing. Thorac Cardiovasc Surg. 2010 Mar;58(2):102-7. PMID: 20333573. X-2, X-3 241. Griesenbach U, Soussi S, Larsen MB, et al. Quantification of periciliary fluid height in human airway biopsies is feasible, 252. Vu LT, Demoulin B, Nguyen MT, et al. Respiratory but not suitable as a biomarker. Am J Respir Cell Mol Biol. impedance and response to salbutamol in asthmatic Vietnamese 2011 Mar;44(3):309-15. PMID: 20418361. X-1 children. Pediatr Pulmonol. 2010 Apr;45(4):380-6. PMID: 20306537. X-2, X-3, X-4 242. Vitacca M, Paneroni M, Trainini D, et al. At home and on demand mechanical cough assistance program for patients with 253. Gardella C, Girosi D, Rossi GA, et al. Tracheal amyotrophic lateral sclerosis. Am J Phys Med Rehabil. 2010 compression by aberrant innominate artery: clinical May;89(5):401-6. PMID: 20407305. X-5 presentations in infants and children, indications for surgical correction by aortopexy, and short- and long-term outcome. J 243. Bourdin G, Barbier J, Burle JF, et al. The feasibility of Pediatr Surg. 2010 Mar;45(3):564-73. PMID: 20223321. X-2, early physical activity in intensive care unit patients: a X-3, X-4 prospective observational one-center study. Respir Care. 2010 Apr;55(4):400-7. PMID: 20406506. X-3, X-4 254. Furuichi M, Takeda S, Akada S, et al. Noninvasive positive pressure ventilation in patients with perioperative negative 244. Pavithran P, Pujary K, Mahesh SG, et al. Customised pressure pulmonary edema. J Anesth. 2010 Jun;24(3):464-8. acrylic nasal stents following recanalisation of modified Young's PMID: 20221646. X-2, X-3, X-4 procedure. J Laryngol Otol. 2010 Aug;124(8):864-7. PMID: 20398438. X-2, X-3, X-4 255. Brooker GE, Cooper MG. Airway management for infants with severe micrognathia having mandibular distraction 245. Oscroft NS, Quinnell TG, Shneerson JM, et al. The effects osteogenesis. Anaesth Intensive Care. 2010 Jan;38(1):43-9. of withdrawing long-term nocturnal non-invasive ventilation in PMID: 20191776. X-2, X-3, X-4 COPD patients. COPD. 2010 Apr;7(2):111-6. PMID: 20397811. X-3, X-5 256. van der Kloot WA, Chotkan SA, Kaptein AA, et al. Diagnostic delay in sternocostoclavicular hyperostosis: impact 246. Needham DM, Korupolu R, Zanni JM, et al. Early physical on various aspects of quality of life. Arthritis Care Res medicine and rehabilitation for patients with acute respiratory (Hoboken). 2010 Feb;62(2):251-7. PMID: 20191525. X-2, X-3, failure: a quality improvement project. Arch Phys Med Rehabil. X-4 2010 Apr;91(4):536-42. PMID: 20382284. X-2, X-3, X-4 257. Keramidas ME, Debevec T, Amon M, et al. Respiratory 247. Chung TN, Kim SW, Cho YS, et al. Effect of vehicle speed muscle endurance training: effect on normoxic and hypoxic on the quality of closed-chest compression during ambulance exercise performance. Eur J Appl Physiol. 2010 transport. Resuscitation. 2010 Jul;81(7):841-7. PMID: Mar;108(4):759-69. PMID: 20187281. X-2, X-3, X-4, X-5 20378237. X-1 258. Dellaca RL, Gobbi A, Pastena M, et al. Home monitoring 248. Yuan N, Kane P, Shelton K, et al. Safety, tolerability, and of within-breath respiratory mechanics by a simple and efficacy of high-frequency chest wall oscillation in pediatric

Appendix-27 automatic forced oscillation technique device. Physiol Meas. Planning Software in the assessment of patients before lung 2010 Apr;31(4):N11-24. PMID: 20182000. X-2, X-3, X-4, X-5 resection surgery. Eur J Cardiothorac Surg. 2010 May;37(5):1185-90. PMID: 20122845. X-2, X-3, X-4 259. Sodhi KS, Aiyappan SK, Saxena AK, et al. Utility of multidetector CT and virtual bronchoscopy in tracheobronchial 269. Lee AL, Cecins N, Hill CJ, et al. The effects of pulmonary obstruction in children. Acta Paediatr. 2010 Jul;99(7):1011-5. rehabilitation in patients with non-cystic fibrosis bronchiectasis: PMID: 20178519. X-2, X-3, X-4, X-5 protocol for a randomised controlled trial. BMC Pulm Med. 2010;10:5. PMID: 20122281. X-1 260. Ley S, Loukanov T, Ley-Zaporozhan J, et al. Long-term outcome after external tracheal stabilization due to congenital 270. Hundozi-Hysenaj H, Dallku IB, Murtezani A, et al. tracheal instability. Ann Thorac Surg. 2010 Mar;89(3):918-25. Treatment of the idiopathic scoliosis with brace and PMID: 20172154. X-2, X-3, X-4 physiotherapy. Niger J Med. 2009 Jul-Sep;18(3):256-9. PMID: 20120640. X-2, X-3, X-4, X-5 261. Sutbeyaz ST, Koseoglu F, Inan L, et al. Respiratory muscle training improves cardiopulmonary function and exercise 271. Finder JD. Airway clearance modalities in neuromuscular tolerance in subjects with subacute stroke: a randomized disease. Paediatr Respir Rev. 2010 Mar;11(1):31-4. PMID: controlled trial. Clin Rehabil. 2010 Mar;24(3):240-50. PMID: 20113989. X-1 20156979. X-2, X-3, X-4 272. Liddell F, Webber J. Pulmonary rehabilitation for chronic 262. Esposito F, Limonta E, Alberti G, et al. Effect of obstructive pulmonary disease: a pilot study evaluating a once- respiratory muscle training on maximum aerobic power in weekly versus twice-weekly supervised programme. normoxia and hypoxia. Respir Physiol Neurobiol. 2010 Mar Physiotherapy. 2010 Mar;96(1):68-74. PMID: 20113765. X-2, 31;170(3):268-72. PMID: 20156604. X-2, X-3, X-4, X-5 X-3, X-4, X-5

263. Mendes RG, Simoes RP, De Souza Melo Costa F, et al. 273. Sodhi C, Singh S, Dandona PK. A study of the effect of Short-term supervised inpatient physiotherapy exercise protocol yoga training on pulmonary functions in patients with bronchial improves cardiac autonomic function after coronary artery asthma. Indian J Physiol Pharmacol. 2009 Apr-Jun;53(2):169- bypass graft surgery--a randomised controlled trial. Disabil 74. PMID: 20112821. X-3, X-4, X-5 Rehabil. 2010;32(16):1320-7. PMID: 20156053. X-2, X-3, X-4 274. Sun Y, Liu JX, Jiang H, et al. Cardiovascular responses and 264. Waterhouse JC, Walters SJ, Oluboyede Y, et al. A airway complications following awake nasal intubation with randomised 2 x 2 trial of community versus hospital pulmonary blind intubation device and fibreoptic bronchoscope: a rehabilitation, followed by telephone or conventional follow-up. randomized controlled study. Eur J Anaesthesiol. 2010 Health Technol Assess. 2010 Feb;14(6):i-v, vii-xi, 1-140. May;27(5):461-7. PMID: 20090540. X-2, X-3, X-4 PMID: 20146902. X-2, X-3, X-4, X-5 275. Hashmi NK, Mandel JE, Mirza N. Laryngeal mask airway 265. Reeve JC, Nicol K, Stiller K, et al. Does physiotherapy in laryngoscopies: a safer alternative for the difficult airway. reduce the incidence of postoperative pulmonary complications ORL J Otorhinolaryngol Relat Spec. 2009;71(6):342-6. PMID: following pulmonary resection via open thoracotomy? A 20090393. X-2, X-3, X-4 preliminary randomised single-blind clinical trial. Eur J Cardiothorac Surg. 2010 May;37(5):1158-66. PMID: 20138778. 276. Fernandez I, Valladolid G, Varon J, et al. Encounters with X-3, X-4 venomous sea-life. J Emerg Med. 2011 Jan;40(1):103-12. PMID: 20045606. X-1 266. Mazzarella F, Alesii A, Dall'armi V, et al. Alexithymia in respiratory rehabilitation. Disabil Rehabil. 2010;32(13):1116-21. 277. Bodmann I, Dierich M, Fuehner T, et al. Vibration PMID: 20131946. X-2, X-3, X-4, X-5 response imaging (VRI) in lung transplant recipients. Ther Adv Respir Dis. 2010 Feb;4(1):3-11. PMID: 20042451. X-2, X-3, X- 267. Valero C, Monteagudo M, Llagostera M, et al. Evaluation 4, X-5 of a combined strategy directed towards health-care professionals and patients with chronic obstructive pulmonary 278. Bach JR, Goncalves MR, Hamdani I, et al. Extubation of disease (COPD): information and health education feedback for patients with neuromuscular weakness: a new management improving clinical monitoring and quality-of-life. BMC Public paradigm. Chest. 2010 May;137(5):1033-9. PMID: 20040608. Health. 2009;9:442. PMID: 20128887. X-2, X-3, X-4, X-5 X-2, X-3, X-4, X-6

268. Jimenez U, Marina N, de Santamaria EL, et al. Evaluation 279. Klepczynska Nystrom A, Svartengren M, Grunewald J, et of the utility of vibration response imaging device and Operation al. Health effects of a subway environment in healthy

Appendix-28 volunteers. Eur Respir J. 2010 Aug;36(2):240-8. PMID: 290. Nguyen TU, Diong B, Goldman M. A study of IOS data 20032018. X-2, X-3, X-4, X-5 using the aRIC+I(p) model of respiratory impedance. Conf Proc IEEE Eng Med Biol Soc. 2009;2009:2875-8. PMID: 19963786. 280. Wojtecka-Lukasik E, Ksiezopolska-Orlowska K, X-2, X-3, X-4, X-5 Gaszewska E, et al. Cryotherapy decreases histamine levels in the blood of patients with rheumatoid arthritis. Inflamm Res. 291. Elsherif AM, Park AH, Alder SC, et al. Indicators of a 2010 Mar;59 Suppl 2:S253-5. PMID: 20020313. X-2, X-3, X-4, more complicated clinical course for pediatric patients with X-5 retropharyngeal abscess. Int J Pediatr Otorhinolaryngol. 2010 Feb;74(2):198-201. PMID: 19963280. X-1 281. Dreher M, Ekkernkamp E, Storre JH, et al. Sedation during flexible bronchoscopy in patients with pre-existing respiratory 292. Thamboo A, Nguyen T, Ludemann JP. Choking failure: Midazolam versus Midazolam plus Alfentanil. prevention: shortcomings of traditional public education Respiration. 2010;79(4):307-14. PMID: 20016132. X-2, X-3, X- campaigns, prompting the development of web-based interactive 4, X-5 teaching tools for preteens, teenagers, and adults. J Otolaryngol Head Neck Surg. 2009 Dec;38(6):646-51. PMID: 19958728. X- 282. Rawlins L, Woollard M, Williams J, et al. Effect of 2, X-3, X-4, X-5 listening to Nellie the Elephant during CPR training on performance of chest compressions by lay people: randomised 293. Zoremba M, Kalmus G, Dette F, et al. Effect of intra- crossover trial. BMJ. 2009;339:b4707. PMID: 20008376. X-2, operative pressure support vs pressure controlled ventilation on X-3, X-4, X-5 oxygenation and lung function in moderately obese adults. Anaesthesia. 2010 Feb;65(2):124-9. PMID: 19958342. X-2, X- 283. Sriranjini SJ, Pal PK, Krishna N, et al. Subclinical 3, X-4 pulmonary dysfunction in spinocerebellar ataxias 1, 2 and 3. Acta Neurol Scand. 2010 Nov;122(5):323-8. PMID: 20002004. 294. Sinha A, Sharma B, Sood J. ProSeal laryngeal mask airway X-2, X-3, X-4, X-5 in infants and toddlers with upper respiratory tract infections: a randomized control trial of spontaneous vs pressure control 284. Barbano L, Bertella E, Vitacca M. Episodic medical home ventilation. Middle East J Anesthesiol. 2009 Oct;20(3):437-42. interventions in severe bedridden chronic respiratory failure PMID: 19950740. X-2, X-3, X-4 patients: a 4 year retrospective study. Monaldi Arch Chest Dis. 2009 Sep;71(3):113-8. PMID: 19999957. X-2, X-3, X-4, X-5 295. D'Agostino J. Pediatric airway nightmares. Emerg Med Clin North Am. 2010 Feb;28(1):119-26. PMID: 19945602. X-1 285. Delage A, Tillie-Leblond I, Cavestri B, et al. Cryptogenic hemoptysis in chronic obstructive pulmonary disease: 296. Walker RW, Ravi R, Haylett K. Effect of cricoid force on characteristics and outcome. Respiration. 2010;80(5):387-92. airway calibre in children: a bronchoscopic assessment. Br J PMID: 19996573. X-3, X-4 Anaesth. 2010 Jan;104(1):71-4. PMID: 19942611. X-2, X-3, X- 4 286. Michaud G, Reddy C, Ernst A. Whole-lung lavage for pulmonary alveolar proteinosis. Chest. 2009 Dec;136(6):1678- 297. Liberman M. Bronchoscopic evaluation of the trachea and 81. PMID: 19995769. X-2, X-3, X-4 dilation of the trachea. Semin Thorac Cardiovasc Surg. 2009 Fall;21(3):255-62. PMID: 19942125. X-1, X-2, X-3, X-4, X-5, 287. Tyler TF, Nicholas SJ, Lee SJ, et al. Correction of posterior X-6 shoulder tightness is associated with symptom resolution in patients with internal impingement. Am J Sports Med. 2010 298. Tramont CV, Faria AC, Lopes AJ, et al. Influence of the Jan;38(1):114-9. PMID: 19966099. X-2, X-3, X-4, X-5 ageing process on the resistive and reactive properties of the respiratory system. Clinics (Sao Paulo). 2009;64(11):1065-73. 288. Lee J, Lee YW, O'Clock G, et al. Induced respiratory PMID: 19936180. X-2, X-3, X-4 system modeling by high frequency chest compression using lumped system identification method. Conf Proc IEEE Eng Med 299. Bagan P, Berna P, Brian E, et al. Induction chemotherapy Biol Soc. 2009;2009:5486-9. PMID: 19965047. X-2, X-4, X-5 before sleeve lobectomy for lung cancer: immediate and long- term results. Ann Thorac Surg. 2009 Dec;88(6):1732-5. PMID: 289. Diong B, Grainger J, Goldman M, et al. A comparison of 19932225. X-2, X-3, X-4 linear respiratory system models based on parameter estimates from PRN forced oscillation data. Conf Proc IEEE Eng Med 300. Lemes DA, Zin WA, Guimaraes FS. Hyperinflation using Biol Soc. 2009;2009:2879-82. PMID: 19963787. X-2, X-3, X-4 pressure support ventilation improves secretion clearance and respiratory mechanics in ventilated patients with pulmonary

Appendix-29 infection: a randomised crossover trial. Aust J Physiother. 311. Eagan C, Keller CA, Baz MA, et al. Effects of 2009;55(4):249-54. PMID: 19929767. X-3 administration of intravenous naloxone on gas exchange in brain-dead lung donors. Prog Transplant. 2009 Sep;19(3):267- 301. Oostveen E, Dom S, Desager K, et al. Lung function and 71. PMID: 19813490. X-2, X-3, X-4 bronchodilator response in 4-year-old children with different wheezing phenotypes. Eur Respir J. 2010 Apr;35(4):865-72. 312. Reinius H, Jonsson L, Gustafsson S, et al. Prevention of PMID: 19926751. X-2, X-3, X-4, X-5 atelectasis in morbidly obese patients during general anesthesia and paralysis: a computerized tomography study. 302. D'Armiento JM, Scharf SM, Roth MD, et al. Eosinophil Anesthesiology. 2009 Nov;111(5):979-87. PMID: 19809292. X- and T cell markers predict functional decline in COPD patients. 2, X-3, X-4 Respir Res. 2009;10:113. PMID: 19925666. X-2, X-3, X-4 313. Krebs J, Pelosi P, Tsagogiorgas C, et al. Effects of positive 303. Brito MF, Moreira GA, Pradella-Hallinan M, et al. Air end-expiratory pressure on respiratory function and stacking and chest compression increase peak cough flow in hemodynamics in patients with acute respiratory failure with and patients with Duchenne muscular dystrophy. J Bras Pneumol. without intra-abdominal hypertension: a pilot study. Crit Care. 2009 Oct;35(10):973-9. PMID: 19918629. X-3, X-4, X-6 2009;13(5):R160. PMID: 19804634. X-2, X-3, X-4

304. Alves Silva CE, Santos JG, Jansen JM, et al. Laboratory 314. Pifferi M, Bush A, Di Cicco M, et al. Health-related quality evaluation of the Acapella device: pressure characteristics under of life and unmet needs in patients with primary ciliary different conditions, and a software tool to optimize its practical dyskinesia. Eur Respir J. 2010 Apr;35(4):787-94. PMID: use. Respir Care. 2009 Nov;54(11):1480-7. PMID: 19863832. 19797134. X-2, X-3, X-4, X-5 X-2, X-4, X-5 315. Gimenez M, Servera E, Abril E, et al. Comprehensive 305. Chatwin M, Simonds AK. The addition of mechanical directed breathing retraining improves exertional dyspnea for insufflation/exsufflation shortens airway-clearance sessions in men with spirometry within normal limits. Am J Phys Med neuromuscular patients with chest infection. Respir Care. 2009 Rehabil. 2010 Feb;89(2):90-8. PMID: 19789433. X-2, X-3, X-4 Nov;54(11):1473-9. PMID: 19863831. X-3 316. Montaudon M, Lederlin M, Reich S, et al. Bronchial 306. Kilding AE, Brown S, McConnell AK. Inspiratory muscle measurements in patients with asthma: comparison of training improves 100 and 200 m swimming performance. Eur J quantitative thin-section CT findings with those in healthy Appl Physiol. 2010 Feb;108(3):505-11. PMID: 19841931. X-2, subjects and correlation with pathologic findings. Radiology. X-3, X-4, X-5 2009 Dec;253(3):844-53. PMID: 19789219. X-2, X-3, X-4

307. Koschel D, Handzhiev S, Wiedemann B, et al. Acute 317. Mochizuki H, Muramatsu R, Hagiwara S, et al. effects of NPPV in interstitial lung disease with chronic Relationship between bronchial hyperreactivity and asthma hypercapnic respiratory failure. Respir Med. 2010 remission during adolescence. Ann Allergy Asthma Immunol. Feb;104(2):291-5. PMID: 19837575. X-2, X-3, X-4, X-5 2009 Sep;103(3):201-5. PMID: 19788016. X-2, X-3, X-4

308. Pupin MK, Riccetto AG, Ribeiro JD, et al. Comparison of 318. Tuppin P, Kusnik-Joinville O, Weill A, et al. Primary the effects that two different respiratory physical therapy health care use and reasons for hospital admissions in dementia techniques have on cardiorespiratory parameters in infants with patients in france: database study for 2007. Dement Geriatr acute viral bronchiolitis. J Bras Pneumol. 2009 Sep;35(9):860-7. Cogn Disord. 2009;28(3):225-32. PMID: 19776574. X-2, X-3, PMID: 19820812. X-2, X-5 X-4, X-5

309. Varela G, Brunelli A, Jimenez MF, et al. Chest drainage 319. Lee CM, Herridge MS, Matte A, et al. Education and suction decreases differential pleural pressure after upper support needs during recovery in acute respiratory distress lobectomy and has no effect after lower lobectomy. Eur J syndrome survivors. Crit Care. 2009;13(5):R153. PMID: Cardiothorac Surg. 2010 Mar;37(3):531-4. PMID: 19819157. X- 19775467. X-2, X-3, X-4, X-5 2, X-3, X-4 320. Dhanasekar G, Simmen D, Briner HR. Breathing straws. J 310. Klein O, Demoulin B, Jean Auque RT, et al. Cerebrospinal Laryngol Otol. 2010 Jan;124(1):73-4. PMID: 19765328. X-1 fluid outflow and intracranial pressure in hydrocephalic patients with external ventricular drainage. Acta Neurol Scand. 2010 321. Chen LH, Zhang X, Li SQ, et al. The risk factors for Aug;122(2):140-7. PMID: 19814755. X-2, X-3, X-4 hypoxemia in children younger than 5 years old undergoing rigid bronchoscopy for foreign body removal. Anesth Analg. 2009 Oct;109(4):1079-84. PMID: 19762735. X-2, X-3, X-4

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322. Ragavan AJ, Evrensel CA, Krumpe P. Interactions of 333. Veiga J, Lopes AJ, Jansen JM, et al. Effects of airway airflow oscillation, tracheal inclination, and mucus elasticity obstruction on albuterol-mediated variations in the resistive and significantly improve simulated cough clearance. Chest. 2010 elastic properties of the respiratory system of patients with Feb;137(2):355-61. PMID: 19762551. X-1 asthma. J Bras Pneumol. 2009 Jul;35(7):645-52. PMID: 19669002. X-1 323. Verges S, Renggli AS, Notter DA, et al. Effects of different respiratory muscle training regimes on fatigue-related variables 334. Kruger J, Shpringer C, Picard E, et al. Thoracic air leakage during volitional hyperpnoea. Respir Physiol Neurobiol. 2009 in the presentation of cast bronchitis. Chest. 2009 Dec 31;169(3):282-90. PMID: 19761874. X-2, X-5 Aug;136(2):615-7. PMID: 19666761. X-2, X-3, X-4

324. Fauroux B, Leboulanger N, Roger G, et al. Noninvasive 335. Krimsky WS, Broussard JN, Sarkar SA, et al. positive-pressure ventilation avoids recannulation and facilitates Bronchoscopic spray cryotherapy: assessment of safety and early weaning from tracheotomy in children. Pediatr Crit Care depth of airway injury. J Thorac Cardiovasc Surg. 2010 Med. 2010 Jan;11(1):31-7. PMID: 19752776. X-2, X-3 Mar;139(3):781-2. PMID: 19664781. X-1

325. Zosky GR, Cannizzaro V, Hantos Z, et al. Protective 336. Yang SC, Lin YF. Airway function and respiratory mechanical ventilation does not exacerbate lung function resistance in Taiwanese coal workers with simple impairment or lung inflammation following influenza A pneumoconiosis. Chang Gung Med J. 2009 Jul-Aug;32(4):438- infection. J Appl Physiol. 2009 Nov;107(5):1472-8. PMID: 46. PMID: 19664351. X-2, X-3, X-4 19745194. X-2, X-3, X-4, X-5 337. Springmeyer SC, Bolliger CT, Waddell TK, et al. 326. Terragni PP, Del Sorbo L, Mascia L, et al. Tidal volume Treatment of heterogeneous emphysema using the spiration IBV lower than 6 ml/kg enhances lung protection: role of valves. Thorac Surg Clin. 2009 May;19(2):247-53, ix-x. PMID: extracorporeal carbon dioxide removal. Anesthesiology. 2009 19662968. X-2, X-3, X-4, X-6 Oct;111(4):826-35. PMID: 19741487. X-2, X-3 338. Fujita A, Murata K, Takamori M. Novel method for sputum 327. Kim HY, Shin YH, Jung da W, et al. Resistance and induction using the Lung Flute in patients with suspected reactance in oscillation lung function reflect basal lung function pulmonary tuberculosis. Respirology. 2009 Aug;14(6):899-902. and bronchial hyperresponsiveness respectively. Respirology. PMID: 19659832. X-2, X-3, X-4, X-5 2009 Sep;14(7):1035-41. PMID: 19740263. X-2, X-3 339. Lee SC, Park JH, Kang SW, et al. External control of 328. Sutton RM, Maltese MR, Niles D, et al. Quantitative exhalation for cough assistance: a method for patients with analysis of chest compression interruptions during in-hospital glottis dysfunction and/or tracheostomy. Arch Phys Med resuscitation of older children and adolescents. Resuscitation. Rehabil. 2009 Aug;90(8):1402-7. PMID: 19651275. X-3, X-4, 2009 Nov;80(11):1259-63. PMID: 19733427. X-2, X-3, X-4 X-5

329. Rouhani FN, Brantly ML, Markello TC, et al. Alveolar 340. Mamiya H, Ichinohe T, Kaneko Y. Negative pressure macrophage dysregulation in Hermansky-Pudlak syndrome type pulmonary edema after oral and maxillofacial surgery. Anesth 1. Am J Respir Crit Care Med. 2009 Dec 1;180(11):1114-21. Prog. 2009 Summer;56(2):49-52. PMID: 19642719. X-1 PMID: 19729668. X-1 341. Yanez-Brage I, Pita-Fernandez S, Juffe-Stein A, et al. 330. Schumann C, Hetzel M, Babiak AJ, et al. Endobronchial Respiratory physiotherapy and incidence of pulmonary tumor debulking with a flexible cryoprobe for immediate complications in off-pump coronary artery bypass graft surgery: treatment of malignant stenosis. J Thorac Cardiovasc Surg. 2010 an observational follow-up study. BMC Pulm Med. 2009;9:36. Apr;139(4):997-1000. PMID: 19716140. X-2, X-3 PMID: 19638209. X-3, X-4

331. Wang JS, Hung WP. The effects of a swimming 342. Nam HS, Um SW, Koh WJ, et al. Clinical application of intervention for children with asthma. Respirology. 2009 the Natural Y stent in the management of benign carinal Aug;14(6):838-42. PMID: 19703065. X-2, X-3, X-4, X-5 stenosis. Ann Thorac Surg. 2009 Aug;88(2):432-9. PMID: 19632389. X-2, X-3, X-4 332. Scholes RL, Browning L, Sztendur EM, et al. Duration of anaesthesia, type of surgery, respiratory co-morbidity, predicted 343. Rosiere J, Vader JP, Cavin MS, et al. Appropriateness of VO2max and smoking predict postoperative pulmonary respiratory care: evidence-based guidelines. Swiss Med Wkly. complications after upper abdominal surgery: an observational 2009 Jul 11;139(27-28):387-92. PMID: 19629766. X-1 study. Aust J Physiother. 2009;55(3):191-8. PMID: 19681741. X-1

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344. Ionescu C, Derom E, De Keyser R. Assessment of Laparoendosc Adv Surg Tech A. 2009 Aug;19(4):555-7. PMID: respiratory mechanical properties with constant-phase models in 19575632. X-2, X-3, X-4 healthy and COPD lungs. Comput Methods Programs Biomed. 2010 Jan;97(1):78-85. PMID: 19628290. X-2, X-3, X-4, X-5 355. Harth L, Stuart J, Montgomery C, et al. Physical therapy practice patterns in acute exacerbations of chronic obstructive 345. Shannon H, Gregson R, Stocks J, et al. Repeatability of pulmonary disease. Can Respir J. 2009 May-Jun;16(3):86-92. physiotherapy chest wall vibrations applied to spontaneously PMID: 19557215. X-2, X-3, X-4, X-5, X-6 breathing adults. Physiotherapy. 2009 Mar;95(1):36-42. PMID: 19627684. X-2, X-4, X-5 356. Forgiarini LA, Jr., Carvalho AT, Ferreira Tde S, et al. Physical therapy in the immediate postoperative period after 346. Zoremba M, Dette F, Gerlach L, et al. Short-term abdominal surgery. J Bras Pneumol. 2009 May;35(5):455-9. respiratory physical therapy treatment in the PACU and PMID: 19547854. X-2, X-3, X-4 influence on postoperative lung function in obese adults. Obes Surg. 2009 Oct;19(10):1346-54. PMID: 19626381. X-2, X-3, X- 357. Murray MP, Pentland JL, Hill AT. A randomised crossover 4, X-5 trial of chest physiotherapy in non-cystic fibrosis bronchiectasis. Eur Respir J. 2009 Nov;34(5):1086-92. PMID: 19541717. X-5 347. Burtin C, Clerckx B, Robbeets C, et al. Early exercise in critically ill patients enhances short-term functional recovery. 358. Rogausch A, Sigle J, Seibert A, et al. Feasibility and Crit Care Med. 2009 Sep;37(9):2499-505. PMID: 19623052. X- acceptance of electronic quality of life assessment in general 2, X-3, X-4 practice: an implementation study. Health Qual Life Outcomes. 2009;7:51. PMID: 19493355. X-2, X-3, X-4, X-5 348. Schroeder JW, Jr., Bhandarkar ND, Holinger LD. Synchronous airway lesions and outcomes in infants with severe 359. Xanthos T, Bassiakou E, Koudouna E, et al. Using the 30:2 laryngomalacia requiring supraglottoplasty. Arch Otolaryngol compression-ventilation ratio: five cycles is easier to follow than Head Neck Surg. 2009 Jul;135(7):647-51. PMID: 19620584. X- 2 min of cardiopulmonary resuscitation. Eur J Emerg Med. 2009 2, X-3, X-4 Dec;16(6):339-41. PMID: 19491691. X-2, X-3, X-4, X-5

349. Forti E, Ike D, Barbalho-Moulim M, et al. Effects of chest 360. Ramos MB, Fernandez-Villar A, Rivo JE, et al. Extraction physiotherapy on the respiratory function of postoperative of airway foreign bodies in adults: experience from 1987-2008. gastroplasty patients. Clinics (Sao Paulo). 2009;64(7):683-9. Interact Cardiovasc Thorac Surg. 2009 Sep;9(3):402-5. PMID: PMID: 19606246. X-4 19491125. X-2, X-3, X-4

350. Bar-Yishay E, Matyashchuk E, Mussaffi H, et al. Use of 361. Brandao DC, Lima VM, Filho VG, et al. Reversal of the forced oscillation technique to detect bronchodilation in bronchial obstruction with bi-level positive airway pressure and children: experience from the Schneider Children's Medical nebulization in patients with acute asthma. J Asthma. 2009 Center of Israel. Isr Med Assoc J. 2009 Apr;11(4):198-200. May;46(4):356-61. PMID: 19484669. X-3, X-4, X-5 PMID: 19603589. X-2, X-3, X-4 362. Ozalevli S, Ilgin D, Kul Karaali H, et al. The effect of in- 351. Simoes RP, Castello V, Auad MA, et al. Prevalence of patient chest physiotherapy in lung cancer patients. Support reduced respiratory muscle strength in institutionalized elderly Care Cancer. 2010 Mar;18(3):351-8. PMID: 19471973. X-2, X- people. Sao Paulo Med J. 2009 May;127(2):78-83. PMID: 6 19597682. X-2, X-3, X-4, X-5 363. von Ungern-Sternberg BS, Erb TO, Habre W, et al. The 352. Taylor JD, Fletcher JP, Tiarks J. Impact of physical impact of oral premedication with midazolam on respiratory therapist-directed exercise counseling combined with fitness function in children. Anesth Analg. 2009 Jun;108(6):1771-6. center-based exercise training on muscular strength and exercise PMID: 19448200. X-2, X-3, X-4 capacity in people with type 2 diabetes: a randomized clinical trial. Phys Ther. 2009 Sep;89(9):884-92. PMID: 19589851. X-2, 364. Hoshino Y, Ayuse T, Kurata S, et al. The compensatory X-3, X-4, X-5 responses to upper airway obstruction in normal subjects under propofol anesthesia. Respir Physiol Neurobiol. 2009 Mar 353. Bilan N, Galehgolab BA, Shoaran M. Medical treatment of 31;166(1):24-31. PMID: 19444926. X-2, X-3, X-4 lung collapse in children. Pak J Biol Sci. 2009 Mar 1;12(5):467- 9. PMID: 19579991. X-2, X-3, X-4, X-6 365. Lawlor M, Kealy S, Agnew M, et al. Early discharge care with ongoing follow-up support may reduce hospital 354. Rothenberg SS, Kuenzler KA, Middlesworth W. readmissions in COPD. Int J Chron Obstruct Pulmon Dis. Thoracoscopic lobectomy for severe bronchiectasis in children. J 2009;4:55-60. PMID: 19436695. X-2, X-3, X-4

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366. Bonilha AG, Onofre F, Vieira ML, et al. Effects of singing Health (London). 2009 May;13(3):337-60. PMID: 19366840. X- classes on pulmonary function and quality of life of COPD 1 patients. Int J Chron Obstruct Pulmon Dis. 2009;4:1-8. PMID: 19436683. X-2, X-3, X-4, X-5 377. Vanoirbeek JA, Rinaldi M, De Vooght V, et al. Noninvasive and invasive pulmonary function in mouse models 367. Fischer MJ, Gutenbrunner C, Ptok M. Intensified voice of obstructive and restrictive respiratory diseases. Am J Respir therapy: a new model for the rehabilitation of patients suffering Cell Mol Biol. 2010 Jan;42(1):96-104. PMID: 19346316. X-2, from functional dysphonias. Int J Rehabil Res. 2009 X-3, X-4, X-5 Dec;32(4):348-55. PMID: 19436216. X-2, X-3, X-4, X-5 378. Sinha P, Fauvel NJ, Singh S, et al. Ventilatory ratio: a 368. Nygren-Bonnier M, Markstrom A, Lindholm P, et al. simple bedside measure of ventilation. Br J Anaesth. 2009 Glossopharyngeal pistoning for lung insufflation in children May;102(5):692-7. PMID: 19346233. X-2, X-3, X-4 with spinal muscular atrophy type II. Acta Paediatr. 2009 Aug;98(8):1324-8. PMID: 19432834. X-2, X-3, X-4, X-5 379. Stolz AJ, Lischke R, Schutzner J, et al. Predisposing factors of atelectasis following pulmonary lobectomy. Acta Chir Belg. 369. Kubota M, Shirai G, Nakamori T, et al. Low frequency 2009 Jan-Feb;109(1):81-5. PMID: 19341202. X-2, X-3, X-4 oscillometry parameters in COPD patients are less variable during inspiration than during expiration. Respir Physiol 380. Vargas F, Boyer A, Bui HN, et al. Effect of intrapulmonary Neurobiol. 2009 Apr 30;166(2):73-9. PMID: 19429522. X-2, X- percussive ventilation on expiratory flow limitation in chronic 3, X-4 obstructive pulmonary disease patients. J Crit Care. 2009 Jun;24(2):212-9. PMID: 19327288. X-6 370. Cameron M, Corner A, Diba A, et al. Development of a tracheostomy scoring system to guide airway management after 381. Mestriner RG, Fernandes RO, Steffen LC, et al. Optimum major head and neck surgery. Int J Oral Maxillofac Surg. 2009 design parameters for a therapist-constructed positive- Aug;38(8):846-9. PMID: 19423295. X-2, X-3, X-4 expiratory-pressure therapy bottle device. Respir Care. 2009 Apr;54(4):504-8. PMID: 19327187. X-2, X-3, X-4, X-5 371. von Ungern-Sternberg BS, Petak F, Hantos Z, et al. Changes in functional residual capacity and lung mechanics 382. Lucangelo U, Antonaglia V, Zin WA, et al. High-frequency during surgical repair of congenital heart diseases: effects of percussive ventilation improves perioperatively clinical preoperative pulmonary hemodynamics. Anesthesiology. 2009 evolution in pulmonary resection. Crit Care Med. 2009 Jun;110(6):1348-55. PMID: 19417600. X-2, X-3, X-4 May;37(5):1663-9. PMID: 19325478. X-2, X-3

372. Almarakbi WA, Fawzi HM, Alhashemi JA. Effects of four 383. Barbalho-Moulim MC, Miguel GP, Forti EM, et al. intraoperative ventilatory strategies on respiratory compliance Silicone-ring Roux-en-Y gastric bypass in the treatment of and gas exchange during laparoscopic gastric banding in obese obesity: effects of laparoscopic versus laparotomic surgery on patients. Br J Anaesth. 2009 Jun;102(6):862-8. PMID: respiration. Obes Surg. 2011 Feb;21(2):194-9. PMID: 19403595. X-2, X-3, X-4 19301079. X-2, X-3, X-4

373. Kelly K, Kittelson J, Franklin WA, et al. A randomized 384. Godoy RF, Teixeira PJ, Becker Junior B, et al. Long-term phase II chemoprevention trial of 13-CIS retinoic acid with or repercussions of a pulmonary rehabilitation program on the without alpha tocopherol or observation in subjects at high risk indices of anxiety, depression, quality of life and physical for lung cancer. Cancer Prev Res (Phila). 2009 May;2(5):440-9. performance in patients with COPD. J Bras Pneumol. 2009 PMID: 19401528. X-2, X-3, X-4, X-5 Feb;35(2):129-36. PMID: 19287915. X-2, X-3, X-4, X-5

374. Zhou Y, Chen D, Ma X, et al. Postconditioning in 385. Carratu P, Spicuzza L, Cassano A, et al. Early treatment cardiopulmonary resuscitation: a better protocol for with noninvasive positive pressure ventilation prolongs survival cardiopulmonary resuscitation. Med Hypotheses. 2009 in Amyotrophic Lateral Sclerosis patients with nocturnal Sep;73(3):321-3. PMID: 19394152. X-2, X-3, X-4 respiratory insufficiency. Orphanet J Rare Dis. 2009;4:10. PMID: 19284546. X-2, X-3, X-4, X-5 375. Lafond D, Dimmock M, Champagne A, et al. Intrasession reliability and influence of breathing during clinical assessment 386. Windisch W, Haenel M, Storre JH, et al. High-intensity of lumbar spine postural control. Physiother Theory Pract. 2009 non-invasive positive pressure ventilation for stable hypercapnic Apr;25(3):218-27. PMID: 19384740. X-2, X-3, X-4 COPD. Int J Med Sci. 2009;6(2):72-6. PMID: 19277252. X-2, X-3, X-4, X-5 376. Nicholls DA, Walton JA, Price K. Making breathing your business: enterprising practices at the margins of orthodoxy.

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437. Patman S, Jenkins S, Stiller K. Physiotherapy does not 448. Blattner C, Guaragna JC, Saadi E. Oxygenation and static prevent, or hasten recovery from, ventilator-associated compliance is improved immediately after early manual pneumonia in patients with acquired brain injury. Intensive Care hyperinflation following myocardial revascularisation: a Med. 2009 Feb;35(2):258-65. PMID: 18813910. X-6 randomised controlled trial. Aust J Physiother. 2008;54(3):173- 8. PMID: 18721120. X-3, X-4 438. Rhee SC, Kim JS. A simple method of fabricating nasal packing armed with ventilation tube. J Craniofac Surg. 2008 449. Herdy AH, Marcchi PL, Vila A, et al. Pre- and Sep;19(5):1385-6. PMID: 18812868. X-2, X-3, X-4 postoperative cardiopulmonary rehabilitation in hospitalized patients undergoing coronary artery bypass surgery: a 439. Petitjean T, Philit F, Germain-Pastenne M, et al. Sleep and randomized controlled trial. Am J Phys Med Rehabil. 2008 respiratory function after withdrawal of noninvasive ventilation Sep;87(9):714-9. PMID: 18716482. X-2, X-3, X-4, X-5, X-6 in patients with chronic respiratory failure. Respir Care. 2008 Oct;53(10):1316-23. PMID: 18811993. X-2, X-3, X-4 450. Jin F, Mu D, Chu D, et al. Severe complications of bronchoscopy. Respiration. 2008;76(4):429-33. PMID: 440. Volpe MS, Adams AB, Amato MB, et al. Ventilation 18716395. X-2, X-3, X-4, X-6 patterns influence airway secretion movement. Respir Care. 2008 Oct;53(10):1287-94. PMID: 18811989. X-1 451. Lofdahl MJ, Roos-Engstrand E, Pourazar J, et al. Increased intraepithelial T-cells in stable COPD. Respir Med. 2008 441. Slats AM, Janssen K, de Jeu RC, et al. Enhanced airway Dec;102(12):1812-8. PMID: 18706796. X-2, X-3, X-4, X-5 dilation by positive-pressure inflation of the lungs compared with active deep inspiration in patients with asthma. J Appl 452. Funk DJ, Lujan E, Moretti EW, et al. A brief report: the use Physiol. 2008 Dec;105(6):1725-32. PMID: 18801966. X-3, X-5 of high-frequency oscillatory ventilation for severe pulmonary contusion. J Trauma. 2008 Aug;65(2):390-5. PMID: 18695477. X-2, X-3, X-4

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453. Yeldan I, Gurses HN, Yuksel H. Comparison study of chest Otorhinolaryngol. 2008 Sep;72(9):1335-43. PMID: 18603307. physiotherapy home training programmes on respiratory X-2, X-3, X-4, X-5 functions in patients with muscular dystrophy. Clin Rehabil. 2008 Aug;22(8):741-8. PMID: 18678574. X-3, X-4, X-5 464. Laffont I, Bensmail D, Lortat-Jacob S, et al. Intermittent positive-pressure breathing effects in patients with high spinal 454. Gayan J, Gonzalez-Perez A, Bermudo F, et al. A method cord injury. Arch Phys Med Rehabil. 2008 Aug;89(8):1575-9. for detecting epistasis in genome-wide studies using case- PMID: 18602082. X-2, X-3, X-4, X-5, X-6 control multi-locus association analysis. BMC Genomics. 2008;9:360. PMID: 18667089. X-2, X-3, X-4, X-5 465. Morris PE, Goad A, Thompson C, et al. Early intensive care unit mobility therapy in the treatment of acute respiratory 455. Cecins N, Geelhoed E, Jenkins SC. Reduction in failure. Crit Care Med. 2008 Aug;36(8):2238-43. PMID: hospitalisation following pulmonary rehabilitation in patients 18596631. X-3, X-4, X-5 with COPD. Aust Health Rev. 2008 Aug;32(3):415-22. PMID: 18666869. X-2, X-3, X-4, X-5, X-6 466. Mutalithas K, Watkin G, Willig B, et al. Improvement in health status following bronchopulmonary hygiene physical 456. Kooi EM, Schokker S, Marike Boezen H, et al. Fluticasone therapy in patients with bronchiectasis. Respir Med. 2008 or montelukast for preschool children with asthma-like Aug;102(8):1140-4. PMID: 18585027. X-5, X-6 symptoms: Randomized controlled trial. Pulm Pharmacol Ther. 2008 Oct;21(5):798-804. PMID: 18647656. X-2, X-3, X-4, X-5 467. Nouraei SA, Giussani DA, Howard DJ, et al. Physiological comparison of spontaneous and positive-pressure ventilation in 457. Reeve JC, Nicol K, Stiller K, et al. Does physiotherapy laryngotracheal stenosis. Br J Anaesth. 2008 Sep;101(3):419-23. reduce the incidence of postoperative complications in patients PMID: 18577538. X-2, X-3, X-4 following pulmonary resection via thoracotomy? a protocol for a randomised controlled trial. J Cardiothorac Surg. 2008;3:48. 468. Greene CL, Reemtsen B, Polimenakos A, et al. Role of PMID: 18634549. X-1, X-4, X-6 clinically indicated transbronchial lung biopsies in the management of pediatric post-lung transplant patients. Ann 458. Celebi S, Koner O, Menda F, et al. Pulmonary effects of Thorac Surg. 2008 Jul;86(1):198-203. PMID: 18573423. X-2, noninvasive ventilation combined with the recruitment X-3, X-4, X-5 maneuver after cardiac surgery. Anesth Analg. 2008 Aug;107(2):614-9. PMID: 18633041. X-2, X-3, X-4 469. Di Meo F, Pedone C, Lubich S, et al. Age does not hamper the response to pulmonary rehabilitation of COPD patients. Age 459. Guessous I, Cornuz J, Stoianov R, et al. Efficacy of clinical Ageing. 2008 Sep;37(5):530-5. PMID: 18565981. X-2, X-3, X- guideline implementation to improve the appropriateness of 4, X-5 chest physiotherapy prescription among inpatients with community-acquired pneumonia. Respir Med. 2008 470. Vilas-Boas F, Feitosa GS, Soares MB, et al. Invasive and Sep;102(9):1257-63. PMID: 18619824. X-2, X-3, X-4 noninvasive correlations of B-type natriuretic peptide in patients with heart failure due to Chagas cardiomyopathy. Congest Heart 460. Ray AD, Pendergast DR, Lundgren CE. Respiratory muscle Fail. 2008 May-Jun;14(3):121-6. PMID: 18550922. X-2, X-3, training improves swimming endurance at depth. Undersea X-4, X-5 Hyperb Med. 2008 May-Jun;35(3):185-96. PMID: 18619114. X-2, X-3, X-4, X-5 471. Lopes AJ, Mogami R, Capone D, et al. High-resolution computed tomography in silicosis: correlation with chest 461. Goosey-Tolfrey V, Foden E, Perret C, et al. Effects of radiography and pulmonary function tests. J Bras Pneumol. 2008 inspiratory muscle training on respiratory function and repetitive May;34(5):264-72. PMID: 18545821. X-2, X-3, X-4, X-5 sprint performance in wheelchair basketball players. Br J Sports Med. 2010 Jul;44(9):665-8. PMID: 18603575. X-3, X-4, X-5 472. Shen KR, Wain JC, Wright CD, et al. Postpneumonectomy syndrome: surgical management and long-term results. J Thorac 462. Bagan P, Le Pimpec-Barthes F, Badia A, et al. Bronchial Cardiovasc Surg. 2008 Jun;135(6):1210-6; discussion 6-9. sleeve resections: lung function resurrecting procedure. Eur J PMID: 18544355. X-2, X-3, X-4, X-5 Cardiothorac Surg. 2008 Sep;34(3):484-7. PMID: 18603442. X- 2, X-3, X-4, X-5 473. Mark Z, Bajzik G, Nagy A, et al. Comparison of virtual and fiberoptic bronchoscopy in the management of airway stenosis. 463. Correa EC, Berzin F. Mouth Breathing Syndrome: cervical Pathol Oncol Res. 2008 Sep;14(3):313-9. PMID: 18543081. X- muscles recruitment during nasal inspiration before and after 2, X-3, X-4, X-5 respiratory and postural exercises on Swiss Ball. Int J Pediatr

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495. Chan AL, Juarez MM, Allen RP, et al. Do airway metallic 507. Morell F, Roger A, Reyes L, et al. Bird fancier's lung: a stents for benign lesions confer too costly a benefit? BMC Pulm series of 86 patients. Medicine (Baltimore). 2008 Med. 2008;8:7. PMID: 18423035. X-2, X-3, X-4, X-5 Mar;87(2):110-30. PMID: 18344808. X-2, X-3, X-4, X-5

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497. Dobosiewicz K, Durmala J, Kotwicki T. Dobosiewicz 509. Erickson JI, Daniels AA, Smith ME, et al. Recognizing method physiotherapy for idiopathic scoliosis. Stud Health clinical excellence at all levels of practice: a multidisciplinary Technol Inform. 2008;135:228-36. PMID: 18401093. X-1 clinical recognition program. J Nurs Adm. 2008 Feb;38(2):68- 75. PMID: 18300838. X-1 498. Bertrand S, Cuny S, Petit P, et al. Traumatic rupture of thoracic aorta in real-world motor vehicle crashes. Traffic Inj 510. Roh JL, Hong SJ. Lung recovery after rigid bronchoscopic Prev. 2008 Jun;9(2):153-61. PMID: 18398779. X-2, X-3, X-4, removal of tracheobronchial foreign bodies in children. Int J X-5 Pediatr Otorhinolaryngol. 2008 May;72(5):635-41. PMID: 18295351. X-2, X-3, X-4 499. Tetzlaff K, Scholz T, Walterspacher S, et al. Characteristics of the respiratory mechanical and muscle function of 511. Alves LA, Pitta F, Brunetto AF. Performance analysis of competitive breath-hold divers. Eur J Appl Physiol. 2008 the Flutter VRP1 under different flows and angles. Respir Care. Jul;103(4):469-75. PMID: 18398589. X-2, X-3, X-4, X-5 2008 Mar;53(3):316-23. PMID: 18291047. X-2, X-3, X-4, X-5, X-6 500. Piirila PL, Meuronen A, Majuri ML, et al. Inflammation and functional outcome in diisocyanate-induced asthma after 512. Marchal F, Schweitzer C, Werts F, et al. Post-exercise cessation of exposure. Allergy. 2008 May;63(5):583-91. PMID: airway narrowing in healthy primary school children. Pediatr 18394133. X-2, X-3, X-5 Res. 2008 Mar;63(3):328-31. PMID: 18287972. X-2, X-3, X-4, X-5 501. Ligabue T, Voltolini L, Ghiribelli C, et al. Abscess of residual lobe after pulmonary resection for lung cancer. Asian 513. Chandra RK, Rohman GT, Walsh WE. Anterior palate Cardiovasc Thorac Ann. 2008 Apr;16(2):112-4. PMID: sensory impairment after septal surgery. Am J Rhinol. 2008 Jan- 18381867. X-2, X-3, X-4 Feb;22(1):86-8. PMID: 18284865. X-2, X-3, X-4

502. Basek P, Bajrami S, Straub D, et al. The pulmonary 514. Tsolaki V, Pastaka C, Karetsi E, et al. One-year non- outcome of long-term survivors after congenital diaphragmatic invasive ventilation in chronic hypercapnic COPD: effect on hernia repair. Swiss Med Wkly. 2008 Mar 22;138(11-12):173-9. quality of life. Respir Med. 2008 Jun;102(6):904-11. PMID: PMID: 18363115. X-2, X-3, X-4 18280131. X-3, X-5

503. Garcia S, Rocha M, Pinto P, et al. Inspiratory muscle 515. Wos M, Sanak M, Soja J, et al. The presence of rhinovirus training in COPD patients. Rev Port Pneumol. 2008 Mar- in lower airways of patients with bronchial asthma. Am J Respir Apr;14(2):177-94. PMID: 18363017. X-2, X-3, X-4, X-5, X-6 Crit Care Med. 2008 May 15;177(10):1082-9. PMID: 18276945. X-3, X-4, X-5 504. Bahraminasab A, Ghasemi F, Stefanovska A, et al. Direction of coupling from phases of interacting oscillators: a 516. Mercat A, Richard JC, Vielle B, et al. Positive end- permutation information approach. Phys Rev Lett. 2008 Feb expiratory pressure setting in adults with acute lung injury and 29;100(8):084101. PMID: 18352623. X-2, X-3, X-4, X-5 acute respiratory distress syndrome: a randomized controlled trial. JAMA. 2008 Feb 13;299(6):646-55. PMID: 18270353. X- 505. Harnisch W, Brosch S, Schmidt M, et al. Breathing and 2, X-3, X-4 voice quality after surgical treatment for bilateral vocal cord paralysis. Arch Otolaryngol Head Neck Surg. 2008 517. Lee YW, Lee J, Warwick WJ. The comparison of three Mar;134(3):278-84. PMID: 18347253. X-2, X-3, X-4 high-frequency chest compression devices. Biomed Instrum Technol. 2008 Jan-Feb;42(1):68-75. PMID: 18257642. X-2, X- 506. Fraga Ade M, Reis MC, Zambon MP, et al. Foreign body 4, X-5 aspiration in children: clinical aspects, radiological aspects and bronchoscopic treatment. J Bras Pneumol. 2008 Feb;34(2):74- 518. Roytman MM, Thomas SM, Jiang CS. Comparison of 82. PMID: 18345450. X-2, X-3, X-4 practice patterns of hospitalists and community physicians in the

Appendix-39 care of patients with congestive heart failure. J Hosp Med. 2008 patients during anesthesia and paralysis. Anesthesiology. 2007 Jan;3(1):35-41. PMID: 18257099. X-2, X-3, X-4 Nov;107(5):725-32. PMID: 18073547. X-2, X-3, X-4, X-5

519. Cowie RL, Conley DP, Underwood MF, et al. A 530. Nakamura M, Iwahashi M, Nakamori M, et al. An analysis randomised controlled trial of the Buteyko technique as an of the factors contributing to a reduction in the incidence of adjunct to conventional management of asthma. Respir Med. pulmonary complications following an esophagectomy for 2008 May;102(5):726-32. PMID: 18249107. X-3, X-4, X-5 esophageal cancer. Langenbecks Arch Surg. 2008 Mar;393(2):127-33. PMID: 18071746. X-2, X-3, X-4, X-6 520. Sartori R, Barbi E, Poli F, et al. Respiratory training with a specific device in cystic fibrosis: a prospective study. J Cyst 531. Fauroux B, Guillemot N, Aubertin G, et al. Physiologic Fibros. 2008 Jul;7(4):313-9. PMID: 18243067. X-2, X-5 benefits of mechanical insufflation-exsufflation in children with neuromuscular diseases. Chest. 2008 Jan;133(1):161-8. PMID: 521. Law RK, Lee EW, Poon PY, et al. The functional capacity 18071020. X-3, X-4, X-5 of healthcare workers with history of severe acute respiratory distress syndrome (SARS) complicated with avascular necrosis-- 532. Mikkola AK, Aro JL, Rannikko AS, et al. A high case report. Work. 2008;30(1):17-26. PMID: 18198435. X-2, X- pretreatment plasma oestradiol level is associated with a low 3, X-4, X-5 risk of acute myocardial infarction in parenteral oestrogen therapy for locally advanced prostate cancer. BJU Int. 2008 522. Lin SM, Lin TY, Chou CL, et al. Metallic stent and flexible May;101(9):1090-5. PMID: 18070186. X-2, X-3, X-4, X-5 bronchoscopy without fluoroscopy for acute respiratory failure. Eur Respir J. 2008 May;31(5):1019-23. PMID: 18184680. X-3 533. Hirschhorn AD, Richards D, Mungovan SF, et al. Supervised moderate intensity exercise improves distance 523. Indinnimeo L, Tancredi G, Barreto M, et al. Effects of a walked at hospital discharge following coronary artery bypass program of hospital-supervised chest physical therapy on lung graft surgery--a randomised controlled trial. Heart Lung Circ. function tests in children with chronic respiratory disease: 1-year 2008 Apr;17(2):129-38. PMID: 18060837. X-2, X-3, X-4, X-5 follow-up. Int J Immunopathol Pharmacol. 2007 Oct- Dec;20(4):841-5. PMID: 18179758. X-5 534. Toussaint M, Soudon P, Kinnear W. Effect of non-invasive ventilation on respiratory muscle loading and endurance in 524. Menon B, Aggarwal B, Iqbal A. Mounier-Kuhn syndrome: patients with Duchenne muscular dystrophy. Thorax. 2008 report of 8 cases of tracheobronchomegaly with associated May;63(5):430-4. PMID: 18057095. X-2, X-3, X-4, X-6 complications. South Med J. 2008 Jan;101(1):83-7. PMID: 18176298. X-2, X-3, X-4, X-5 535. Murgu SD, Colt HG. Complications of silicone stent insertion in patients with expiratory central airway collapse. Ann 525. Harrison RM. Preliminary investigation into the role of Thorac Surg. 2007 Dec;84(6):1870-7. PMID: 18036901. X-2, physiotherapists in disaster response. Prehosp Disaster Med. X-3, X-4, X-5 2007 Sep-Oct;22(5):462-5; discussion 6. PMID: 18087919. X-2, X-3, X-4, X-5 536. Crisafulli E, Coletti O, Costi S, et al. Effectiveness of erdosteine in elderly patients with bronchiectasis and 526. Moeller A, Lehmann A, Knauer N, et al. Effects of hypersecretion: a 15-day, prospective, parallel, open-label, pilot montelukast on subjective and objective outcome measures in study. Clin Ther. 2007 Sep;29(9):2001-9. PMID: 18035199. X- preschool asthmatic children. Pediatr Pulmonol. 2008 3, X-5 Feb;43(2):179-86. PMID: 18085698. X-2, X-3, X-4, X-5 537. Souza Pinto V, Bammann RH. Chest physiotherapy for 527. Carenzio G, Gherardi P, Bardoni MT, et al. Rehabilitation collecting sputum samples from HIV-positive patients suspected of chronic graft versus host disease in children. A clinical series. of having tuberculosis. Int J Tuberc Lung Dis. 2007 Eura Medicophys. 2007 Dec;43(4):445-50. PMID: 18084166. Dec;11(12):1302-7. PMID: 18034950. X-2, X-4, X-5 X-2, X-3, X-4, X-5 538. Dellweg D, Schonhofer B, Haidl PM, et al. Short-term 528. Westwood K, Griffin M, Roberts K, et al. Incentive effect of controlled instead of assisted noninvasive ventilation in spirometry decreases respiratory complications following major chronic respiratory failure due to chronic obstructive pulmonary abdominal surgery. Surgeon. 2007 Dec;5(6):339-42. PMID: disease. Respir Care. 2007 Dec;52(12):1734-40. PMID: 18080608. X-3, X-4 18028564. X-2, X-3, X-4, X-5

529. Valenza F, Vagginelli F, Tiby A, et al. Effects of the beach 539. Korabiewska L, Lewandowska M, Juskowa J, et al. Need chair position, positive end-expiratory pressure, and for rehabilitation in renal replacement therapy involving pneumoperitoneum on respiratory function in morbidly obese

Appendix-40 allogeneic kidney transplantation. Transplant Proc. 2007 550. Cardoso PF, Snell GI, Hopkins P, et al. Clinical application Nov;39(9):2776-7. PMID: 18021985. X-2, X-3, X-4, X-5, X-6 of airway bypass with paclitaxel-eluting stents: early results. J Thorac Cardiovasc Surg. 2007 Oct;134(4):974-81. PMID: 540. Yang P, Frier BC, Goodman L, et al. Respiratory muscle 17903516. X-2, X-3, X-4, X-5 training and the performance of a simulated anti-G straining maneuver. Aviat Space Environ Med. 2007 Nov;78(11):1035- 551. Zhao Y, Jiao J, Shan Z, et al. Effective management of 41. PMID: 18018435. X-2, X-3, X-4, X-5 main bronchial rupture in patients with chest trauma. Thorac Cardiovasc Surg. 2007 Oct;55(7):447-9. PMID: 17902068. X-1 541. Meraz E, Nazeran H, Diong B, et al. Modeling human respiratory impedance in Hispanic asthmatic children. Conf Proc 552. Hess DR. Airway clearance: physiology, pharmacology, IEEE Eng Med Biol Soc. 2007;2007:4251-4. PMID: 18002941. techniques, and practice. Respir Care. 2007 Oct;52(10):1392-6. X-1 PMID: 17894906. X-1, X-2, X-3, X-4, X-5, X-6

542. Lee YW, Lee J, Warwick WJ. Two models of high 553. Coates AL, Green M, Leung K, et al. The challenges of frequency chest compression therapy: interaction of jacket quantitative measurement of lung deposition using 99mTc- pressure and mouth airflow. Conf Proc IEEE Eng Med Biol Soc. DTPA from delivery systems with very different delivery times. 2007;2007:4243-6. PMID: 18002939. X-1 J Aerosol Med. 2007 Fall;20(3):320-30. PMID: 17894538. X-1

543. Talts J, Kivastik J, Jagomagi K. Amplitude analysis of 554. Dreher M, Rauter I, Storre JH, et al. When should home pressure oscillations after interruption of tidal breathing in mechanical ventilation be started in patients with different preschool children. Conf Proc IEEE Eng Med Biol Soc. neuromuscular disorders? Respirology. 2007 Sep;12(5):749-53. 2007;2007:4239-42. PMID: 18002938. X-2, X-3, X-4, X-5 PMID: 17875066. X-2, X-3, X-4, X-5

544. Lee J, Lee YW, Warwick WJ. High frequency chest 555. Romanini W, Muller AP, Carvalho KA, et al. The effects of compression effects heart rate variability. Conf Proc IEEE Eng intermittent positive pressure and incentive spirometry in the Med Biol Soc. 2007;2007:1066-9. PMID: 18002145. X-2, X-3, postoperative of myocardial revascularization. Arq Bras Cardiol. X-4, X-5, X-6 2007 Aug;89(2):94-9, 105-10. PMID: 17874015. X-2, X-3, X-4, X-6 545. Oskoui M, Levy G, Garland CJ, et al. The changing natural history of spinal muscular atrophy type 1. Neurology. 2007 Nov 556. Mihai R, Knottenbelt G, Cook TM. Evaluation of the 13;69(20):1931-6. PMID: 17998484. X-2, X-3, X-4 revised laryngeal tube suction: the laryngeal tube suction II in 100 patients. Br J Anaesth. 2007 Nov;99(5):734-9. PMID: 546. Casati M, Picca M, Marinello R, et al. Safety of use, 17872934. X-2, X-3, X-4, X-5 efficacy and degree of parental satisfaction with the nasal aspirator Narhinel in the treatment of nasal congestion in babies. 557. Garrod R, Lasserson T. Role of physiotherapy in the Minerva Pediatr. 2007 Aug;59(4):315-25. PMID: 17947838. X- management of chronic lung diseases: an overview of systematic 2, X-3, X-4, X-5 reviews. Respir Med. 2007 Dec;101(12):2429-36. PMID: 17870457. X-5, X-6 547. Decalmer S, Woodcock A, Greaves M, et al. Airway abnormalities at flexible bronchoscopy in patients with chronic 558. Engel RM, Vemulpad S. The effect of combining manual cough. Eur Respir J. 2007 Dec;30(6):1138-42. PMID: therapy with exercise on the respiratory function of normal 17928312. X-1 individuals: a randomized control trial. J Manipulative Physiol Ther. 2007 Sep;30(7):509-13. PMID: 17870419. X-2, X-3, X-4, 548. Goto Y, Kohzuki M, Meguro M, et al. Long-term X-5 beneficial effects of lung volume reduction surgery on quality of life in patients with chronic obstructive pulmonary disease. 559. Gregson RK, Stocks J, Petley GW, et al. Simultaneous Tohoku J Exp Med. 2007 Oct;213(2):157-66. PMID: 17917409. measurement of force and respiratory profiles during chest X-2, X-3, X-4, X-5 physiotherapy in ventilated children. Physiol Meas. 2007 Sep;28(9):1017-28. PMID: 17827650. X-2, X-4, X-5, X-6 549. Tendulkar RD, Fleming PA, Reddy CA, et al. High-dose- rate endobronchial brachytherapy for recurrent airway 560. Carone M, Patessio A, Ambrosino N, et al. Efficacy of obstruction from hyperplastic granulation tissue. Int J Radiat pulmonary rehabilitation in chronic respiratory failure (CRF) Oncol Biol Phys. 2008 Mar 1;70(3):701-6. PMID: 17904764. X- due to chronic obstructive pulmonary disease (COPD): The 2, X-3, X-4, X-5 Maugeri Study. Respir Med. 2007 Dec;101(12):2447-53. PMID: 17728121. X-2, X-3, X-4, X-5

Appendix-41

561. Loukanov T, Gorenflo M, Sebening C, et al. Surgical 572. French LC, Wootten CT, Thomas RG, et al. Tracheotomy treatment of long-segment tracheal anomalies in infants and in the preschool population: indications and outcomes. children. Thorac Cardiovasc Surg. 2007 Sep;55(6):375-9. Otolaryngol Head Neck Surg. 2007 Aug;137(2):280-3. PMID: PMID: 17721847. X-1 17666256. X-2, X-3, X-4

562. Strange C, Herth FJ, Kovitz KL, et al. Design of the 573. Sehlin M, Ohberg F, Johansson G, et al. Physiological Endobronchial Valve for Emphysema Palliation Trial (VENT): a responses to positive expiratory pressure breathing: a non-surgical method of lung volume reduction. BMC Pulm comparison of the PEP bottle and the PEP mask. Respir Care. Med. 2007;7:10. PMID: 17711594. X-2, X-3, X-4, X-5 2007 Aug;52(8):1000-5. PMID: 17650355. X-2, X-4

563. Arab AM, Salavati M, Ebrahimi I, et al. Sensitivity, 574. Neben-Wittich MA, Foote RL, Kalra S. External beam specificity and predictive value of the clinical trunk muscle radiation therapy for tracheobronchial amyloidosis. Chest. 2007 endurance tests in low back pain. Clin Rehabil. 2007 Jul;132(1):262-7. PMID: 17625086. X-2, X-3, X-4 Jul;21(7):640-7. PMID: 17702706. X-2, X-3, X-4, X-5 575. Nguyen YT, Demoulin B, Schweitzer C, et al. 564. Zinzi P, Salmaso D, De Grandis R, et al. Effects of an Identification of bronchodilator responsiveness by forced intensive rehabilitation programme on patients with oscillation admittance in children. Pediatr Res. 2007 Huntington's disease: a pilot study. Clin Rehabil. 2007 Sep;62(3):348-52. PMID: 17622963. X-2, X-3, X-4 Jul;21(7):603-13. PMID: 17702702. X-2, X-3, X-4, X-5 576. Patterson JE, Hewitt O, Kent L, et al. Acapella versus 565. Mutluay FK, Demir R, Ozyilmaz S, et al. Breathing- 'usual airway clearance' during acute exacerbation in enhanced upper extremity exercises for patients with multiple bronchiectasis: a randomized crossover trial. Chron Respir Dis. sclerosis. Clin Rehabil. 2007 Jul;21(7):595-602. PMID: 2007;4(2):67-74. PMID: 17621572. X-5 17702701. X-2, X-3, X-4, X-5 577. Manninen PH, Jose GB, Lukitto K, et al. Management of 566. Beeson J. Palliation of tracheobronchial carcinoma: the role the airway in patients undergoing cervical spine surgery. J of cryosurgery. J Perioper Pract. 2007 Jul;17(7):332, 4-6, 8-9. Neurosurg Anesthesiol. 2007 Jul;19(3):190-4. PMID: 17592351. PMID: 17702205. X-1 X-2, X-3, X-4, X-6

567. Ernst A, Majid A, Feller-Kopman D, et al. Airway 578. Haddad SH, Aldawood AS, Arabi YM. The diagnostic stabilization with silicone stents for treating adult yield and clinical impact of a chest X-ray after percutaneous tracheobronchomalacia: a prospective observational study. dilatational tracheostomy: a prospective cohort study. Anaesth Chest. 2007 Aug;132(2):609-16. PMID: 17699133. X-2, X-3, X- Intensive Care. 2007 Jun;35(3):393-7. PMID: 17591135. X-2, 4, X-5 X-3, X-4, X-6

568. Lehrer PM, Karavidas MK, Lu SE, et al. Psychological 579. Budweiser S, Murbeth RE, Jorres RA, et al. Predictors of treatment of comorbid asthma and panic disorder: a pilot study. long-term survival in patients with restrictive thoracic disorders J Anxiety Disord. 2008 May;22(4):671-83. PMID: 17693054. and chronic respiratory failure undergoing non-invasive home X-2, X-3, X-4, X-5 ventilation. Respirology. 2007 Jul;12(4):551-9. PMID: 17587422. X-2, X-3, X-4, X-5 569. Leal RC, Bertelli EC, Soler ZA. Recurrent pneumonia caused by genetic immunodeficiency: a prophylactic and 580. Becker DE, Haas DA. Management of complications rehabilitative approach. Braz J Infect Dis. 2007 Jun;11(3):307- during moderate and deep sedation: respiratory and 10. PMID: 17684629. X-2, X-3, X-4, X-5 cardiovascular considerations. Anesth Prog. 2007 Summer;54(2):59-68; quiz 9. PMID: 17579505. X-1 570. von Ungern-Sternberg BS, Regli A, Frei FJ, et al. Decrease in functional residual capacity and ventilation homogeneity after 581. Holloway EA, West RJ. Integrated breathing and relaxation neuromuscular blockade in anesthetized preschool children in training (the Papworth method) for adults with asthma in the lateral position. Paediatr Anaesth. 2007 Sep;17(9):841-5. primary care: a randomised controlled trial. Thorax. 2007 PMID: 17683401. X-2, X-3, X-4 Dec;62(12):1039-42. PMID: 17573445. X-2, X-3, X-4, X-5

571. Lindholm P, Wylegala J, Pendergast DR, et al. Resistive 582. Nouraei SA, Obholzer R, Ind PW, et al. Results of respiratory muscle training improves and maintains endurance endoscopic surgery and intralesional steroid therapy for airway swimming performance in divers. Undersea Hyperb Med. 2007 compromise due to tracheobronchial Wegener's granulomatosis. May-Jun;34(3):169-80. PMID: 17672173. X-2, X-3, X-4, X-5 Thorax. 2008 Jan;63(1):49-52. PMID: 17573443. X-2, X-3, X-4, X-5

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583. Budweiser S, Jorres RA, Riedl T, et al. Predictors of 594. Unzueta MC, Casas JI, Moral MV. Pressure-controlled survival in COPD patients with chronic hypercapnic respiratory versus volume-controlled ventilation during one-lung ventilation failure receiving noninvasive home ventilation. Chest. 2007 for thoracic surgery. Anesth Analg. 2007 May;104(5):1029-33, Jun;131(6):1650-8. PMID: 17565016. X-2, X-3, X-4, X-5 tables of contents. PMID: 17456648. X-2, X-3, X-4

584. Khaliq AA, Huang CY, Ganti AK, et al. Comparison of 595. Cilli A, Ozkaynak C, Onur R, et al. Lung cancer detection resource utilization and clinical outcomes between teaching and with low-dose spiral computed tomography in chronic nonteaching medical services. J Hosp Med. 2007 May;2(3):150- obstructive pulmonary disease patients. Acta Radiol. 2007 7. PMID: 17549749. X-2, X-3, X-4 May;48(4):405-11. PMID: 17453521. X-2, X-3, X-4, X-5

585. Young B, Raihan S, Ladak H, et al. Rhythmic artifact of 596. Lee HY, Yang HJ, Cho YN. Minimally invasive mandible physiotherapy in intensive care unit EEG recordings. J Clin reduction using Lee's Rasp & Saw. Aesthetic Plast Surg. 2007 Neurophysiol. 2007 Jun;24(3):252-6. PMID: 17545828. X-1 Mar-Apr;31(2):201-5. PMID: 17429561. X-2, X-3, X-4, X-5

586. Lechtzin N, Scott Y, Busse AM, et al. Early use of non- 597. Loring SH, O'Donnell C R, Feller-Kopman DJ, et al. invasive ventilation prolongs survival in subjects with ALS. Central airway mechanics and flow limitation in acquired Amyotroph Lateral Scler. 2007 Jun;8(3):185-8. PMID: tracheobronchomalacia. Chest. 2007 Apr;131(4):1118-24. 17538782. X-2, X-3, X-4 PMID: 17426218. X-2, X-3, X-4, X-5

587. Huber JE. Effect of cues to increase sound pressure level 598. Kim JH, Shin JH, Song HY, et al. Tracheobronchial on respiratory kinematic patterns during connected speech. J laceration after balloon dilation for benign strictures: incidence Speech Lang Hear Res. 2007 Jun;50(3):621-34. PMID: and clinical significance. Chest. 2007 Apr;131(4):1114-7. 17538105. X-2, X-3, X-4, X-5, X-6 PMID: 17426217. X-2, X-3, X-4, X-5

588. Reeve J, Denehy L, Stiller K. The physiotherapy 599. Reilly J, Washko G, Pinto-Plata V, et al. Biological lung management of patients undergoing thoracic surgery: a survey volume reduction: a new bronchoscopic therapy for advanced of current practice in Australia and New Zealand. Physiother emphysema. Chest. 2007 Apr;131(4):1108-13. PMID: Res Int. 2007 Jun;12(2):59-71. PMID: 17536644. X-1 17426216. X-2, X-3, X-4, X-5

589. von Ungern-Sternberg BS, Regli A, Schibler A, et al. The 600. Eaton T, Young P, Zeng I, et al. A randomized evaluation impact of positive end-expiratory pressure on functional residual of the acute efficacy, acceptability and tolerability of flutter and capacity and ventilation homogeneity impairment in active cycle of breathing with and without postural drainage in anesthetized children exposed to high levels of inspired oxygen. non-cystic fibrosis bronchiectasis. Chron Respir Dis. Anesth Analg. 2007 Jun;104(6):1364-8, table of contents. 2007;4(1):23-30. PMID: 17416150. X-2, X-5, X-6 PMID: 17513627. X-2, X-3, X-4 601. Nygren-Bonnier M, Lindholm P, Markstrom A, et al. 590. Deakin CD, O'Neill JF, Tabor T. Does compression-only Effects of glossopharyngeal pistoning for lung insufflation on cardiopulmonary resuscitation generate adequate passive vital capacity in healthy women. Am J Phys Med Rehabil. 2007 ventilation during cardiac arrest? Resuscitation. 2007 Apr;86(4):290-4. PMID: 17413541. X-2, X-3, X-4, X-5 Oct;75(1):53-9. PMID: 17507138. X-2, X-3, X-4, X-5 602. Jeon K, Kim H, Yu CM, et al. Rigid bronchoscopic 591. le Roux FH, Bouic PJ, Bester MM. The effect of Bach's intervention in patients with respiratory failure caused by magnificat on emotions, immune, and endocrine parameters malignant central airway obstruction. J Thorac Oncol. 2006 during physiotherapy treatment of patients with infectious lung May;1(4):319-23. PMID: 17409877. X-2, X-3, X-4 conditions. J Music Ther. 2007 Summer;44(2):156-68. PMID: 17484523. X-2, X-3, X-4 603. Irdesel J, Aydiner SB, Akgoz S. Rehabilitation outcome after traumatic brain injury. Neurocirugia (Astur). 2007 592. Nygren-Bonnier M, Gullstrand L, Klefbeck B, et al. Effects Feb;18(1):5-15. PMID: 17393041. X-3, X-4, X-6 of glossopharyngeal pistoning for lung insufflation in elite swimmers. Med Sci Sports Exerc. 2007 May;39(5):836-41. 604. Su CL, Chiang LL, Chiang TY, et al. Domiciliary positive PMID: 17468583. X-2, X-3, X-4, X-5 expiratory pressure improves pulmonary function and exercise capacity in patients with chronic obstructive pulmonary disease. 593. Butcher SJ, Pasiorowski MP, Jones RL. Effects of changes J Formos Med Assoc. 2007 Mar;106(3):204-11. PMID: in lung volume on oscillatory flow rate during high-frequency 17389164. X-2, X-5 chest wall oscillation. Can Respir J. 2007 Apr;14(3):153-8. PMID: 17464379. X-2, X-4, X-5

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605. Galvan CC, Cataneo AJ. Effect of respiratory muscle surgery. Respir Med. 2007 Jul;101(7):1572-8. PMID: 17257820. training on pulmonary function in preoperative preparation of X-2, X-3, X-4, X-5 tobacco smokers. Acta Cir Bras. 2007 Mar-Apr;22(2):98-104. PMID: 17375214. X-2, X-3, X-4, X-5 616. Hall GL, Sly PD, Fukushima T, et al. Respiratory function in healthy young children using forced oscillations. Thorax. 606. Schokker S, Kooi EM, de Vries TW, et al. Inhaled 2007 Jun;62(6):521-6. PMID: 17251315. X-2, X-3, X-4, X-5 corticosteroids for recurrent respiratory symptoms in preschool children in general practice: randomized controlled trial. Pulm 617. Gulec H, Sayar K. Reliability and validity of the Turkish Pharmacol Ther. 2008;21(1):88-97. PMID: 17350868. X-2, X-3, form of the Somatosensory Amplification Scale. Psychiatry Clin X-4, X-5 Neurosci. 2007 Feb;61(1):25-30. PMID: 17239035. X-2, X-3, X-4, X-5 607. Banjar HH. Clinical profile of Saudi children with bronchiectasis. Indian J Pediatr. 2007 Feb;74(2):149-52. PMID: 618. Athanassiadi K, Kakaris S, Theakos N, et al. Muscle- 17337827. X-2, X-3, X-4, X-5 sparing versus posterolateral thoracotomy: a prospective study. Eur J Cardiothorac Surg. 2007 Mar;31(3):496-9; discussion 9- 608. Rassler B, Hallebach G, Kalischewski P, et al. The effect of 500. PMID: 17236781. X-2, X-3, X-4 respiratory muscle endurance training in patients with myasthenia gravis. Neuromuscul Disord. 2007 May;17(5):385- 619. Mikkola A, Aro J, Rannikko S, et al. Ten-year survival and 91. PMID: 17336068. X-3, X-4, X-5 cardiovascular mortality in patients with advanced prostate cancer primarily treated by intramuscular polyestradiol 609. Grillo HC, Wright CD. Tracheal compression with phosphate or orchiectomy. Prostate. 2007 Mar 1;67(4):447-55. "hairpin" right aortic arch: management by aortic division and PMID: 17219379. X-2, X-3, X-4 aortopexy by right thoracotomy guided by intraoperative bronchoscopy. Ann Thorac Surg. 2007 Mar;83(3):1152-7. 620. Wisbach GG, Sise MJ, Sack DI, et al. What is the role of PMID: 17307479. X-1 chest X-ray in the initial assessment of stable trauma patients? J Trauma. 2007 Jan;62(1):74-8; discussion 8-9. PMID: 17215736. 610. Huitink JM, Balm AJ, Keijzer C, et al. Awake fibrecapnic X-2, X-3, X-4 intubation in head and neck cancer patients with difficult airways: new findings and refinements to the technique. 621. Bernardi L, Passino C, Spadacini G, et al. Reduced hypoxic Anaesthesia. 2007 Mar;62(3):214-9. PMID: 17300296. X-2, X- ventilatory response with preserved blood oxygenation in yoga 3, X-4, X-6 trainees and Himalayan Buddhist monks at altitude: evidence of a different adaptive strategy? Eur J Appl Physiol. 2007 611. Toussaint M, Steens M, Soudon P. Lung function Mar;99(5):511-8. PMID: 17206440. X-2, X-3, X-4, X-5 accurately predicts hypercapnia in patients with Duchenne muscular dystrophy. Chest. 2007 Feb;131(2):368-75. PMID: 622. Wood DE, McKenna RJ, Jr., Yusen RD, et al. A 17296635. X-2, X-3, X-4, X-5 multicenter trial of an intrabronchial valve for treatment of severe emphysema. J Thorac Cardiovasc Surg. 2007 612. de Mesquita Junior JA, Lopes AJ, Jansen JM, et al. Using Jan;133(1):65-73. PMID: 17198782. X-2, X-3, X-4, X-5 the forced oscillation technique to evaluate respiratory resistance in individuals with silicosis. J Bras Pneumol. 2006 May- 623. Pushparajah S, McClellan R, Henry A, et al. Use of a Jun;32(3):213-20. PMID: 17273610. X-2, X-3, X-4, X-5 chronic disease management programme in COPD to reduce hospital admissions. Chron Respir Dis. 2006;3(4):187-93. 613. Moreira Jda S, Camargo Jde J, Felicetti JC, et al. Lung PMID: 17190121. X-3, X-4, X-5 abscess: analysis of 252 consecutive cases diagnosed between 1968 and 2004. J Bras Pneumol. 2006 Mar-Apr;32(2):136-43. 624. Tsuruta R, Kasaoka S, Okabayashi K, et al. Efficacy and PMID: 17273583. X-2, X-3, X-4 safety of intrapulmonary percussive ventilation superimposed on conventional ventilation in obese patients with compression 614. O'Neill B, McKevitt A, Rafferty S, et al. A comparison of atelectasis. J Crit Care. 2006 Dec;21(4):328-32. PMID: twice- versus once-weekly supervision during pulmonary 17175419. X-2, X-3, X-4, X-6 rehabilitation in chronic obstructive pulmonary disease. Arch Phys Med Rehabil. 2007 Feb;88(2):167-72. PMID: 17270513. 625. Chhajed PN, Baty F, Pless M, et al. Outcome of treated X-2, X-3, X-4, X-5 advanced non-small cell lung cancer with and without central airway obstruction. Chest. 2006 Dec;130(6):1803-7. PMID: 615. Perrin C, Jullien V, Venissac N, et al. Prophylactic use of 17167000. X-2, X-3, X-4, X-5, X-6 noninvasive ventilation in patients undergoing lung resectional

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626. Prys-Picard CO, Kellett F, Niven RM. Disproportionate 637. Zeidler MR, Goldin JG, Kleerup EC, et al. Small airways breathlessness associated with deep sighing breathing in a response to naturalistic cat allergen exposure in subjects with patient presenting with difficult-to-treat asthma. Chest. 2006 asthma. J Allergy Clin Immunol. 2006 Nov;118(5):1075-81. Dec;130(6):1723-5. PMID: 17166988. X-1 PMID: 17088132. X-2, X-3, X-4, X-5

627. Hirschberg H, Sun CH, Krasieva T, et al. Effects of ALA- 638. Murry T, Tabaee A, Owczarzak V, et al. Respiratory mediated photodynamic therapy on the invasiveness of human retraining therapy and management of laryngopharyngeal reflux glioma cells. Lasers Surg Med. 2006 Dec;38(10):939-45. PMID: in the treatment of patients with cough and paradoxical vocal 17163479. X-1 fold movement disorder. Ann Otol Rhinol Laryngol. 2006 Oct;115(10):754-8. PMID: 17076097. X-2, X-3, X-4, X-5 628. Wright CD. Sleeve lobectomy in lung cancer. Semin Thorac Cardiovasc Surg. 2006 Summer;18(2):92-5. PMID: 639. Jastrzebski D, Gumola A, Gawlik R, et al. Dyspnea and 17157226. X-1 quality of life in patients with pulmonary fibrosis after six weeks of respiratory rehabilitation. J Physiol Pharmacol. 2006 Sep;57 629. Tomlinson AE, Nysaether J, Kramer-Johansen J, et al. Suppl 4:139-48. PMID: 17072040. X-2, X-3, X-4, X-5 Compression force-depth relationship during out-of-hospital cardiopulmonary resuscitation. Resuscitation. 2007 640. Michelet P, D'Journo XB, Roch A, et al. Protective Mar;72(3):364-70. PMID: 17141936. X-2, X-3, X-4, X-5 ventilation influences systemic inflammation after esophagectomy: a randomized controlled study. Anesthesiology. 630. Budweiser S, Moertl M, Jorres RA, et al. Respiratory 2006 Nov;105(5):911-9. PMID: 17065884. X-2, X-3, X-4 muscle training in restrictive thoracic disease: a randomized controlled trial. Arch Phys Med Rehabil. 2006 Dec;87(12):1559- 641. Yerushalmi R, Fenig E, Shitrit D, et al. Endobronchial stent 65. PMID: 17141634. X-2, X-3, X-4, X-5 for malignant airway obstructions. Isr Med Assoc J. 2006 Sep;8(9):615-7. PMID: 17058411. X-2, X-3, X-4, X-5 631. McCarren B, Alison JA, Herbert RD. Manual vibration increases expiratory flow rate via increased intrapleural pressure 642. Yaegashi M, Yalamanchili VA, Kaza V, et al. The utility of in healthy adults: an experimental study. Aust J Physiother. the forced oscillation technique in assessing bronchodilator 2006;52(4):267-71. PMID: 17132121. X-2, X-3, X-4, X-5 responsiveness in patients with asthma. Respir Med. 2007 May;101(5):995-1000. PMID: 17056244. X-2, X-3, X-4, X-5 632. Klimek AT, Klimek A. The weighted walking test as an alternative method of assessing aerobic power. J Sports Sci. 643. Burini D, Farabollini B, Iacucci S, et al. A randomised 2007 Jan 15;25(2):143-8. PMID: 17127589. X-2, X-3, X-4, X-5 controlled cross-over trial of aerobic training versus Qigong in advanced Parkinson's disease. Eura Medicophys. 2006 633. Kim Y, Kim K, Joe J, et al. Changes in the levels of Sep;42(3):231-8. PMID: 17039221. X-2, X-3, X-4, X-5 interferon-gamma and transforming growth factor-beta influence bronchial stenosis during the treatment of endobronchial 644. Innes AL, Woodruff PG, Ferrando RE, et al. Epithelial tuberculosis. Respiration. 2007;74(2):202-7. PMID: 17124378. mucin stores are increased in the large airways of smokers with X-2, X-3, X-4, X-5 airflow obstruction. Chest. 2006 Oct;130(4):1102-8. PMID: 17035444. X-2, X-3, X-4, X-5 634. Pedreira WL, Jr., de Souza R, Fiks IN, et al. Functional implications of BAL in the presence of restrictive or obstructive 645. Morrison D, Rahman I, MacNee W. Permeability, lung disease. Respir Med. 2007 Jun;101(6):1344-9. PMID: inflammation and oxidant status in airspace epithelium exposed 17118639. X-2, X-3, X-4 to ozone. Respir Med. 2006 Dec;100(12):2227-34. PMID: 17023150. X-2, X-3, X-4, X-5 635. Graham AS, Chandrashekharaiah G, Citak A, et al. Positive end-expiratory pressure and pressure support in peripheral 646. Lo S, Rowe-Jones J. How we do it: Transoral suction airways obstruction : work of breathing in intubated children. diathermy adenoid ablation under direct vision using a 45 degree Intensive Care Med. 2007 Jan;33(1):120-7. PMID: 17111110. endoscope. Clin Otolaryngol. 2006 Oct;31(5):440-2. PMID: X-2, X-3, X-4 17014458. X-1

636. Santillanes G, Gausche-Hill M, Sosa B. Preparedness of 647. von Ungern-Sternberg BS, Hammer J, Schibler A, et al. selected pediatric offices to respond to critical emergencies in Decrease of functional residual capacity and ventilation children. Pediatr Emerg Care. 2006 Nov;22(11):694-8. PMID: homogeneity after neuromuscular blockade in anesthetized 17110859. X-2, X-3, X-4, X-5 young infants and preschool children. Anesthesiology. 2006 Oct;105(4):670-5. PMID: 17006063. X-2, X-3, X-4, X-6

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648. Lange DJ, Lechtzin N, Davey C, et al. High-frequency lung transplantation: Is it worth it? Thorax. 2007 Jan;62(1):57- chest wall oscillation in ALS: an exploratory randomized, 61. PMID: 16928706. X-2, X-3, X-4, X-5 controlled trial. Neurology. 2006 Sep 26;67(6):991-7. PMID: 17000967. X-5 660. Govindarajan R, Ghosh B, Sathyamoorthy MK, et al. Efficacy of ketorolac in lieu of narcotics in the operative 649. Madu CN, Machuzak MS, Sterman DH, et al. High-dose- management of laparoscopic surgery for morbid obesity. Surg rate (HDR) brachytherapy for the treatment of benign Obes Relat Dis. 2005 Nov-Dec;1(6):530-5; discussion 5-6. obstructive endobronchial granulation tissue. Int J Radiat Oncol PMID: 16925285. X-2, X-3, X-4, X-5 Biol Phys. 2006 Dec 1;66(5):1450-6. PMID: 16997502. X-1 661. O'Sullivan PB, Beales DJ. Changes in pelvic floor and 650. Prada Arias M, Jardon Bahia JA, Rodriguez Barca P, et al. diaphragm kinematics and respiratory patterns in subjects with Endobronchial tuberculous granuloma in children. Eur J Pediatr sacroiliac joint pain following a motor learning intervention: a Surg. 2006 Aug;16(4):265-8. PMID: 16981092. X-1 case series. Man Ther. 2007 Aug;12(3):209-18. PMID: 16919496. X-2, X-3, X-4, X-5 651. Ferreira JR, Albuquerque e Sousa J, Foreld P, et al. Abnormal respiratory drive in vibroacoustic disease. Rev Port 662. Rigau J, Montserrat JM, Wohrle H, et al. Bench model to Pneumol. 2006 Jul-Aug;12(4):369-74. PMID: 16969569. X-2, simulate upper airway obstruction for analyzing automatic X-3, X-4, X-5 continuous positive airway pressure devices. Chest. 2006 Aug;130(2):350-61. PMID: 16899832. X-1 652. Altmay E, Karaca P, Yurtseven N, et al. Continuous positive airway pressure does not improve lung function after 663. Lofaso F, Desmarais G, Leroux K, et al. Bench evaluation cardiac surgery. Can J Anaesth. 2006 Sep;53(9):919-25. PMID: of flow limitation detection by automated continuous positive 16960270. X-2, X-3, X-4 airway pressure devices. Chest. 2006 Aug;130(2):343-9. PMID: 16899831. X-1 653. Chiang LL, Wang LY, Wu CP, et al. Effects of physical training on functional status in patients with prolonged 664. Lo Coco D, Marchese S, Pesco MC, et al. Noninvasive mechanical ventilation. Phys Ther. 2006 Sep;86(9):1271-81. positive-pressure ventilation in ALS: predictors of tolerance and PMID: 16959675. X-2, X-3, X-4, X-5 survival. Neurology. 2006 Sep 12;67(5):761-5. PMID: 16899545. X-2, X-3, X-4, X-5 654. Liszner K, Feinberg M. Cough assist strategy for pulmonary toileting in ventilator-dependent spinal cord injured 665. Sjaheim T, Kongerud J, Bjortuft O, et al. Reduced patients. Rehabil Nurs. 2006 Sep-Oct;31(5):218-21. PMID: bronchial CD4+ T-cell density in smokers with occupational 16948444. X-1, X-2, X-4, X-5, X-6 asthma. Eur Respir J. 2006 Dec;28(6):1138-44. PMID: 16899487. X-1 655. Naylor JM, McLean A, Chow CM, et al. A modified postural drainage position produces less cardiovascular stress 666. Pang YK, Liam CK, Leow CH, et al. Tracheobronchial than a head-down position in patients with severe heart disease: stenting is safe and effective in relieving upper airway a quasi-experimental study. Aust J Physiother. 2006;52(3):201- obstruction. Med J Malaysia. 2006 Jun;61(2):147-50. PMID: 9. PMID: 16942455. X-4, X-5, X-6 16898303. X-2, X-3, X-4, X-5

656. Savio C, Garaventa A, Gremmo M, et al. Feasibility of 667. Priftis KN, Anthracopoulos MB, Tsakanika C, et al. integrated home/hospital physiotherapeutic support for children Quantification of siderophages in bronchoalveolar fluid in with cancer. Support Care Cancer. 2007 Jan;15(1):101-4. PMID: transfusional and primary pulmonary hemosiderosis. Pediatr 16941134. X-2, X-3, X-4, X-5 Pulmonol. 2006 Oct;41(10):972-7. PMID: 16871595. X-2, X-3, X-4 657. Hill NS. Neuromuscular disease in respiratory and critical care medicine. Respir Care. 2006 Sep;51(9):1065-71. PMID: 668. Brown R, DiMarco AF, Hoit JD, et al. Respiratory 16934169. X-1 dysfunction and management in spinal cord injury. Respir Care. 2006 Aug;51(8):853-68;discussion 69-70. PMID: 16867197. X- 658. Soler N, Agusti C, Angrill J, et al. Bronchoscopic 1 validation of the significance of sputum purulence in severe exacerbations of chronic obstructive pulmonary disease. Thorax. 669. MacIntyre NR. Muscle dysfunction associated with chronic 2007 Jan;62(1):29-35. PMID: 16928715. X-2, X-3, X-4, X-5 obstructive pulmonary disease. Respir Care. 2006 Aug;51(8):840-7; discussion 8-52. PMID: 16867196. X-1 659. Benden C, Harpur-Sinclair O, Ranasinghe AS, et al. Surveillance bronchoscopy in children during the first year after

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670. Jevon P. Resuscitation skills--part two: clearing the airway. 681. Hasdiraz L, Bicer C, Bilgin M, et al. Turban pin aspiration: Nurs Times. 2006 Jun 27-Jul 3;102(26):26-7. PMID: 16845812. non-asphyxiating tracheobronchial foreign body in young X-1, X-2, X-3, X-4, X-5, X-6 islamic women. Thorac Cardiovasc Surg. 2006 Jun;54(4):273-5. PMID: 16755451. X-1 671. de Oliveira HG, Macedo-Neto AV, John AB, et al. Transbronchoscopic pulmonary emphysema treatment: 1-month 682. Chaisson KM, Walsh S, Simmons Z, et al. A clinical pilot to 24-month endoscopic follow-up. Chest. 2006 Jul;130(1):190- study: high frequency chest wall oscillation airway clearance in 9. PMID: 16840401. X-2, X-3, X-4, X-6 patients with amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2006 Jun;7(2):107-11. PMID: 16753975. X-5 672. Wittmer VL, Simoes GM, Sogame LC, et al. Effects of continuous positive airway pressure on pulmonary function and 683. Polaner DM, Ahuja D, Zuk J, et al. Video assessment of exercise tolerance in patients with congestive heart failure. supraglottic airway orientation through the perilaryngeal airway Chest. 2006 Jul;130(1):157-63. PMID: 16840396. X-2, X-3, X- in pediatric patients. Anesth Analg. 2006 Jun;102(6):1685-8. 4, X-5 PMID: 16717309. X-2, X-3, X-4, X-5

673. Crawford MW, Rohan D, Macgowan CK, et al. Effect of 684. Cavalcanti JV, Lopes AJ, Jansen JM, et al. Detection of propofol anesthesia and continuous positive airway pressure on changes in respiratory mechanics due to increasing degrees of upper airway size and configuration in infants. Anesthesiology. airway obstruction in asthma by the forced oscillation technique. 2006 Jul;105(1):45-50. PMID: 16809993. X-2, X-3 Respir Med. 2006 Dec;100(12):2207-19. PMID: 16713226. X-2, X-3, X-4, X-5 674. Gaissert HA, Grillo HC, Shadmehr MB, et al. Uncommon primary tracheal tumors. Ann Thorac Surg. 2006 Jul;82(1):268- 685. Noppen M, Stratakos G, Amjadi K, et al. Stenting allows 72; discussion 72-3. PMID: 16798228. X-1 weaning and extubation in ventilator- or tracheostomy dependency secondary to benign airway disease. Respir Med. 675. Reychler G, Wallemacq P, Rodenstein DO, et al. 2007 Jan;101(1):139-45. PMID: 16709452. X-2, X-3, X-4 Comparison of lung deposition of amikacin by intrapulmonary percussive ventilation and jet nebulization by urinary 686. Lang SM, Becker A, Fischer R, et al. Acute effects of monitoring. J Aerosol Med. 2006 Summer;19(2):199-207. hemodialysis on lung function in patients with end-stage renal PMID: 16796544. X-2, X-4, X-5 disease. Wien Klin Wochenschr. 2006 Mar;118(3-4):108-13. PMID: 16703255. X-2, X-3, X-4 676. Lindenauer PK, Pekow P, Gao S, et al. Quality of care for patients hospitalized for acute exacerbations of chronic 687. Inoue Y, Tanaka H, Ogura H, et al. A neutrophil elastase obstructive pulmonary disease. Ann Intern Med. 2006 Jun inhibitor, sivelestat, improves leukocyte deformability in 20;144(12):894-903. PMID: 16785478. X-3, X-4, X-6 patients with acute lung injury. J Trauma. 2006 May;60(5):936- 43; discussion 43. PMID: 16688053. X-2, X-3, X-4 677. Saito J, Harris WT, Gelfond J, et al. Physiologic, bronchoscopic, and bronchoalveolar lavage fluid findings in 688. Lechtzin N, Shade D, Clawson L, et al. Supramaximal young children with recurrent wheeze and cough. Pediatr inflation improves lung compliance in subjects with Pulmonol. 2006 Aug;41(8):709-19. PMID: 16779841. X-2, X-3, amyotrophic lateral sclerosis. Chest. 2006 May;129(5):1322-9. X-4, X-5 PMID: 16685025. X-3, X-4

678. De Gracia J, Culebras M, Alvarez A, et al. Bronchoscopic 689. Abou Zeid HA, Arab SA, Al-Ghamdi AM, et al. Airway balloon dilatation in the management of bronchial stenosis management of a rare huge-size supraglottic mass. Saudi Med J. following lung transplantation. Respir Med. 2007 Jan;101(1):27- 2006 May;27(5):711-3. PMID: 16680266. X-1 33. PMID: 16774820. X-2, X-3, X-4, X-5 690. Yuksel M, Ozyurtkan MO, Lacin T, et al. The role of 679. Lumbierres M, Prats E, Farrero E, et al. Noninvasive fluoroscopy in the removal of tracheobronchial pin aspiration. positive pressure ventilation prevents postoperative pulmonary Int J Clin Pract. 2006 Nov;60(11):1451-3. PMID: 16669829. X- complications in chronic ventilators users. Respir Med. 2007 2, X-3, X-4 Jan;101(1):62-8. PMID: 16774819. X-2, X-3, X-4, X-5 691. Kang SW, Kang YS, Sohn HS, et al. Respiratory muscle 680. Schadlich PK, Kentsch M, Weber M, et al. Cost strength and cough capacity in patients with Duchenne muscular effectiveness of enoxaparin as prophylaxis against venous dystrophy. Yonsei Med J. 2006 Apr 30;47(2):184-90. PMID: thromboembolic complications in acutely ill medical inpatients: 16642546. X-2, X-3, X-4, X-5 modelling study from the hospital perspective in Germany. Pharmacoeconomics. 2006;24(6):571-91. PMID: 16761905. X-1

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692. Shiraishi T, Shirakusa T, Miyoshi T, et al. A completely Arch Phys Med Rehabil. 2006 Apr;87(4):468-73. PMID: thoracoscopic lobectomy/segmentectomy for primary lung 16571384. X-2, X-3, X-4, X-5 cancer--technique, feasibility, and advantages. Thorac Cardiovasc Surg. 2006 Apr;54(3):202-7. PMID: 16639684. X-2, 703. Balzar S, Strand M, Nakano T, et al. Subtle X-3, X-4 immunodeficiency in severe asthma: IgA and IgG2 correlate with lung function and symptoms. Int Arch Allergy Immunol. 693. Chhajed PN, Eberhardt R, Dienemann H, et al. Therapeutic 2006;140(2):96-102. PMID: 16557027. X-2, X-3, X-4, X-5 bronchoscopy interventions before surgical resection of lung cancer. Ann Thorac Surg. 2006 May;81(5):1839-43. PMID: 704. Wan IY, Toma TP, Geddes DM, et al. Bronchoscopic lung 16631682. X-2, X-3, X-4, X-6 volume reduction for end-stage emphysema: report on the first 98 patients. Chest. 2006 Mar;129(3):518-26. PMID: 16537847. 694. Rasova K, Havrdova E, Brandejsky P, et al. Comparison of X-2, X-3, X-4 the influence of different rehabilitation programmes on clinical, spirometric and spiroergometric parameters in patients with 705. Slader CA, Reddel HK, Spencer LM, et al. Double blind multiple sclerosis. Mult Scler. 2006 Apr;12(2):227-34. PMID: randomised controlled trial of two different breathing techniques 16629428. X-2, X-3, X-4 in the management of asthma. Thorax. 2006 Aug;61(8):651-6. PMID: 16517572. X-2, X-3, X-4, X-5 695. Ribechini A, Bottici V, Chella A, et al. Interventional bronchoscopy in the treatment of tracheal obstruction secondary 706. Enright SJ, Unnithan VB, Heward C, et al. Effect of high- to advanced thyroid cancer. J Endocrinol Invest. 2006 intensity inspiratory muscle training on lung volumes, Feb;29(2):131-5. PMID: 16610238. X-2, X-3, X-4, X-6 diaphragm thickness, and exercise capacity in subjects who are healthy. Phys Ther. 2006 Mar;86(3):345-54. PMID: 16506871. 696. Young GB, Ives JR, Chapman MG, et al. A comparison of X-2, X-3, X-4, X-5 subdermal wire electrodes with collodion-applied disk electrodes in long-term EEG recordings in ICU. Clin 707. Nava S, Barbarito N, Piaggi G, et al. Physiological Neurophysiol. 2006 Jun;117(6):1376-9. PMID: 16584915. X-2, response to intrapulmonary percussive ventilation in stable X-3, X-4 COPD patients. Respir Med. 2006 Sep;100(9):1526-33. PMID: 16490350. X-6 697. Lucarelli MR, Lucey CR, Mastronarde JG. Survey of current practices in fellowship orientation. Respiration. 708. Nouraei SA, McPartlin DW, Nouraei SM, et al. Objective 2007;74(4):382-6. PMID: 16582534. X-1 sizing of upper airway stenosis: a quantitative endoscopic approach. Laryngoscope. 2006 Jan;116(1):12-7. PMID: 698. Chau-In W, Chinachoti T, Punjasawadi Y, et al. Unplanned 16481801. X-1 intubation during anesthesia: review of 31 cases from the Thai Anesthesia Incidents Study (THAI study). J Med Assoc Thai. 709. Bates JH, Allen GB. The estimation of lung mechanics 2006 Feb;89(2):224-30. PMID: 16579010. X-1 parameters in the presence of pathology: a theoretical analysis. Ann Biomed Eng. 2006 Mar;34(3):384-92. PMID: 16468093. 699. Chin KJ, Chee VW. Laryngeal edema associated with the X-1 ProSeal laryngeal mask airway in upper respiratory tract infection. Can J Anaesth. 2006 Apr;53(4):389-92. PMID: 710. Cox G, Miller JD, McWilliams A, et al. Bronchial 16575039. X-1 thermoplasty for asthma. Am J Respir Crit Care Med. 2006 May 1;173(9):965-9. PMID: 16456145. X-3, X-4, X-5 700. Cardoso AP, Oliveira MJ, Silva AM, et al. Effects of long term exposure to occupational noise on textile industry workers' 711. Slinde F, Kvarnhult K, Gronberg AM, et al. Energy lung function. Rev Port Pneumol. 2006 Jan-Feb;12(1):45-59. expenditure in underweight chronic obstructive pulmonary PMID: 16572256. X-2, X-3, X-4, X-5 disease patients before and during a physiotherapy programme. Eur J Clin Nutr. 2006 Jul;60(7):870-6. PMID: 16452911. X-2, 701. Schweitzer C, Vu LT, Nguyen YT, et al. Estimation of the X-3, X-4, X-5 bronchodilatory effect of deep inhalation after a free run in children. Eur Respir J. 2006 Jul;28(1):89-95. PMID: 16571612. 712. Hartrick CT, Martin G, Kantor G, et al. Evaluation of a X-2, X-3, X-4, X-5 single-dose, extended-release epidural morphine formulation for pain after knee arthroplasty. J Bone Joint Surg Am. 2006 702. Chiara T, Martin AD, Davenport PW, et al. Expiratory Feb;88(2):273-81. PMID: 16452737. X-2, X-3, X-4 muscle strength training in persons with multiple sclerosis having mild to moderate disability: effect on maximal expiratory 713. Budweiser S, Heinemann F, Meyer K, et al. Weight gain in pressure, pulmonary function, and maximal voluntary cough. cachectic COPD patients receiving noninvasive positive-

Appendix-48 pressure ventilation. Respir Care. 2006 Feb;51(2):126-32. in pulmonary lobectomy. Eur J Cardiothorac Surg. 2006 PMID: 16441956. X-2, X-3, X-4 Feb;29(2):216-20. PMID: 16376560. X-3, X-4

714. Xu L, Cai BQ, Zhong X, et al. Respiratory manifestations 725. Woon PY, Curtis AM, Kaisaki PJ, et al. Genomic in amyloidosis. Chin Med J (Engl). 2005 Dec 20;118(24):2027- organization of the rat Clock gene and sequence analysis in 33. PMID: 16438898. X-2, X-3, X-4 inbred rat strains. Genomics. 2006 Feb;87(2):208-17. PMID: 16376516. X-1 715. Moorthy SS, Gupta S, Laurent B, et al. Management of airway in patients with laryngeal tumors. J Clin Anesth. 2005 726. Hailey D, Foerster V, Nakagawa B, et al. Achievements Dec;17(8):604-9. PMID: 16427530. X-2, X-3, X-4 and challenges on policies for allied health professionals who use telehealth in the Canadian Arctic. J Telemed Telecare. 716. Chung YH, Chao TY, Chiu CT, et al. The cuff-leak test is a 2005;11 Suppl 2:S39-41. PMID: 16375792. X-1, X-2, X-3, X-4, simple tool to verify severe laryngeal edema in patients X-5, X-6 undergoing long-term mechanical ventilation. Crit Care Med. 2006 Feb;34(2):409-14. PMID: 16424722. X-2, X-3, X-4, X-5 727. Borghi-Silva A, Mendes RG, Costa Fde S, et al. The influences of positive end expiratory pressure (PEEP) associated 717. Mascia L, Bosma K, Pasero D, et al. Ventilatory and with physiotherapy intervention in phase I cardiac rehabilitation. hemodynamic management of potential organ donors: an Clinics (Sao Paulo). 2005 Dec;60(6):465-72. PMID: 16358136. observational survey. Crit Care Med. 2006 Feb;34(2):321-7; X-4, X-5 quiz 8. PMID: 16424709. X-2, X-3, X-4 728. Ries AL, Make BJ, Lee SM, et al. The effects of pulmonary 718. Marinho PE, Berenguer A, Barros A, et al. Which rehabilitation in the national emphysema treatment trial. Chest. pulmonary volume should be used in physiotherapy to obtain 2005 Dec;128(6):3799-809. PMID: 16354848. X-2, X-3, X-5 higher maximal inspiratory pressure in COPD patients? Physiother Res Int. 2005;10(4):182-9. PMID: 16411613. X-3, 729. Pillastrini P, Bordini S, Bazzocchi G, et al. Study of the X-4 effectiveness of bronchial clearance in subjects with upper spinal cord injuries: examination of a rehabilitation programme 719. Nassar E, Marques IL, Trindade AS, Jr., et al. Feeding- involving mechanical insufflation and exsufflation. Spinal Cord. facilitating techniques for the nursing infant with Robin 2006 Oct;44(10):614-6. PMID: 16344851. X-6 sequence. Cleft Palate Craniofac J. 2006 Jan;43(1):55-60. PMID: 16405375. X-2, X-3, X-4, X-5 730. Passfield L, Dobbins T, Myers S, et al. Acute cardiorespiratory changes induced by hyperpnoea using a respiratory 720. Maher C, Williams M. Factors influencing the use of muscle trainer. Ergonomics. 2005 Sep 15-Nov 15;48(11- outcome measures in physiotherapy management of lung 14):1423-32. PMID: 16338710. X-2, X-3, X-4 transplant patients in Australia and New Zealand. Physiother Theory Pract. 2005 Oct-Dec;21(4):201-17. PMID: 16396432. X- 731. Kitano Y, Nakagawa S, Kuroda T, et al. Liver position in 1 fetal congenital diaphragmatic hernia retains a prognostic value in the era of lung-protective strategy. J Pediatr Surg. 2005 721. Jaquet Y, Monnier P, Van Melle G, et al. Complications of Dec;40(12):1827-32. PMID: 16338299. X-2, X-3, X-4 different ventilation strategies in endoscopic laryngeal surgery: a 10-year review. Anesthesiology. 2006 Jan;104(1):52-9. PMID: 732. Cimbiz A, Bayazit V, Hallaceli H, et al. The effect of 16394690. X-2, X-3, X-4, X-5 combined therapy (spa and physical therapy) on pain in various chronic diseases. Complement Ther Med. 2005 Dec;13(4):244- 722. Naylor JM, Heard R, Chow CM. Physiotherapist attitudes 50. PMID: 16338194. X-2, X-3, X-4, X-5 and practices regarding head-down and modified postural drainage in the presence of heart disease. Physiother Theory 733. Olympia RP, Wan E, Avner JR. The preparedness of Pract. 2005 Apr-Jun;21(2):121-35. PMID: 16392465. X-2, X-3, schools to respond to emergencies in children: a national survey X-4, X-5 of school nurses. Pediatrics. 2005 Dec;116(6):e738-45. PMID: 16322130. X-2, X-3, X-4, X-5 723. Lotti P, Gigliotti F, Tesi F, et al. Respiratory muscles and dyspnea in obese nonsmoking subjects. Lung. 2005 Sep- 734. Lau HM, Ng GY, Jones AY, et al. A randomised controlled Oct;183(5):311-23. PMID: 16389724. X-2, X-3, X-4 trial of the effectiveness of an exercise training program in patients recovering from severe acute respiratory syndrome. 724. Varela G, Ballesteros E, Jimenez MF, et al. Cost- Aust J Physiother. 2005;51(4):213-9. PMID: 16321128. X-2, X- effectiveness analysis of prophylactic respiratory physiotherapy 3, X-4

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735. Shah S, Fung K, Brim S, et al. An in vitro evaluation of the Urol Nephrol. 2005;39(4):294-300. PMID: 16261661. X-2, X-3, effectiveness of endotracheal suction catheters. Chest. 2005 X-4, X-5 Nov;128(5):3699-704. PMID: 16304336. X-1 746. Seren E. Web-based analysis of nasal sound spectra. 736. Shitrit D, Valdsislav P, Grubstein A, et al. Accuracy of Telemed J E Health. 2005 Oct;11(5):578-82. PMID: 16250822. virtual bronchoscopy for grading tracheobronchial stenosis: X-2, X-3, X-4, X-5 correlation with pulmonary function test and fiberoptic bronchoscopy. Chest. 2005 Nov;128(5):3545-50. PMID: 747. Servera E, Sancho J, Zafra MJ, et al. Alternatives to 16304311. X-3, X-4 endotracheal intubation for patients with neuromuscular diseases. Am J Phys Med Rehabil. 2005 Nov;84(11):851-7. 737. Westerdahl E, Lindmark B, Eriksson T, et al. Deep- PMID: 16244522. X-4, X-6 breathing exercises reduce atelectasis and improve pulmonary function after coronary artery bypass surgery. Chest. 2005 748. Nakagawa NK, Franchini ML, Driusso P, et al. Mucociliary Nov;128(5):3482-8. PMID: 16304303. X-3, X-4 clearance is impaired in acutely ill patients. Chest. 2005 Oct;128(4):2772-7. PMID: 16236954. X-2, X-3, X-4 738. Boogaard R, Huijsmans SH, Pijnenburg MW, et al. Tracheomalacia and bronchomalacia in children: incidence and 749. Porta R, Vitacca M, Gile LS, et al. Supported arm training patient characteristics. Chest. 2005 Nov;128(5):3391-7. PMID: in patients recently weaned from mechanical ventilation. Chest. 16304290. X-2, X-3, X-4, X-5, X-6 2005 Oct;128(4):2511-20. PMID: 16236917. X-2, X-3, X-4

739. Giarraffa P, Berger KI, Chaikin AA, et al. Assessing 750. Krause MF, von Bismarck P, Oppermann HC, et al. efficacy of high-frequency chest wall oscillation in patients with Bronchoscopic surfactant administration in pediatric patients familial dysautonomia. Chest. 2005 Nov;128(5):3377-81. with persistent lobar atelectasis. Respiration. 2008;75(1):100-4. PMID: 16304287. X-5 PMID: 16205052. X-2, X-3, X-4, X-6

740. Poggi R, Appendini L, Polese G, et al. Noninvasive 751. Riedel T, Richards T, Schibler A. The value of electrical proportional assist ventilation and pressure support ventilation impedance tomography in assessing the effect of body position during arm elevation in patients with chronic respiratory failure. and positive airway pressures on regional lung ventilation in A preliminary, physiologic study. Respir Med. 2006 spontaneously breathing subjects. Intensive Care Med. 2005 Jun;100(6):972-9. PMID: 16303296. X-2, X-3, X-4 Nov;31(11):1522-8. PMID: 16195908. X-2, X-3, X-4

741. Patterson JE, Bradley JM, Elborn JS. Airway clearance in 752. Lagerkvist AL, Sten G, Westerberg B, et al. Positive bronchiectasis: a randomized crossover trial of active cycle of expiratory pressure (PEP) treatment in children with multiple breathing techniques (incorporating postural drainage and severe disabilities. Acta Paediatr. 2005 May;94(5):538-42. vibration) versus test of incremental respiratory endurance. PMID: 16188740. X-2, X-3, X-4, X-6 Chron Respir Dis. 2004;1(3):127-30. PMID: 16281653. X-5 753. Trappenburg JC, Troosters T, Spruit MA, et al. 742. Nava S, Gregoretti C, Fanfulla F, et al. Noninvasive Psychosocial conditions do not affect short-term outcome of ventilation to prevent respiratory failure after extubation in high- multidisciplinary rehabilitation in chronic obstructive pulmonary risk patients. Crit Care Med. 2005 Nov;33(11):2465-70. PMID: disease. Arch Phys Med Rehabil. 2005 Sep;86(9):1788-92. 16276167. X-2, X-3 PMID: 16181944. X-2, X-3, X-4, X-5

743. Malfatto G, Facchini M, Branzi G, et al. Reverse 754. Lunn W, Garland R, Ashiku S, et al. Microdebrider ventricular remodeling and improved functional capacity after bronchoscopy: a new tool for the interventional bronchoscopist. ventricular resynchronization in advanced heart failure. Ital Ann Thorac Surg. 2005 Oct;80(4):1485-8. PMID: 16181894. X- Heart J. 2005 Jul;6(7):578-83. PMID: 16274020. X-2, X-3, X-4, 1 X-5 755. Howarth PH, Babu KS, Arshad HS, et al. Tumour necrosis 744. Elkins MR, Lane T, Goldberg H, et al. Effect of airway factor (TNFalpha) as a novel therapeutic target in symptomatic clearance techniques on the efficacy of the sputum induction corticosteroid dependent asthma. Thorax. 2005 procedure. Eur Respir J. 2005 Nov;26(5):904-8. PMID: Dec;60(12):1012-8. PMID: 16166100. X-2, X-3, X-4, X-5 16264054. X-2, X-4 756. Fregonezi GA, Resqueti VR, Guell R, et al. Effects of 8- 745. Mikkola A, Aro J, Rannikko S, et al. Cardiovascular week, interval-based inspiratory muscle training and breathing complications in patients with advanced prostatic cancer treated retraining in patients with generalized myasthenia gravis. Chest. by means of orchiectomy or polyestradiol phosphate. Scand J 2005 Sep;128(3):1524-30. PMID: 16162753. X-3, X-4, X-5

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757. Frei J, Jutla J, Kramer G, et al. Impulse oscillometry: 768. Kennedy TC, Franklin WA, Prindiville SA, et al. High reference values in children 100 to 150 cm in height and 3 to 10 prevalence of occult endobronchial malignancy in high risk years of age. Chest. 2005 Sep;128(3):1266-73. PMID: patients with moderate sputum atypia. Lung Cancer. 2005 16162717. X-2, X-3, X-4, X-5 Aug;49(2):187-91. PMID: 16022912. X-2, X-3, X-4

758. van der Wiel EC, Hofhuis W, Holland WP, et al. Predictive 769. Jain N, Covar RA, Gleason MC, et al. Quantitative value of infant lung function testing for airway malacia. Pediatr computed tomography detects peripheral airway disease in Pulmonol. 2005 Nov;40(5):431-6. PMID: 16161085. X-2, X-3, asthmatic children. Pediatr Pulmonol. 2005 Sep;40(3):211-8. X-4 PMID: 16015663. X-2, X-3, X-4, X-5

759. Kang SW, Shin JC, Park CI, et al. Relationship between 770. Caramez MP, Borges JB, Tucci MR, et al. Paradoxical inspiratory muscle strength and cough capacity in cervical spinal responses to positive end-expiratory pressure in patients with cord injured patients. Spinal Cord. 2006 Apr;44(4):242-8. airway obstruction during controlled ventilation. Crit Care Med. PMID: 16151446. X-2, X-3, X-4 2005 Jul;33(7):1519-28. PMID: 16003057. X-2, X-3, X-4, X-6

760. Frank GE, Trimmel H, Fitzgerald RD. Inspiratory 771. Vinograd I, Keidar S, Weinberg M, et al. Treatment of oscillatory flow with a portable ventilator: a bench study. Crit airway obstruction by metallic stents in infants and children. J Care. 2005 Aug;9(4):R315-22. PMID: 16137343. X-2, X-3, X-4 Thorac Cardiovasc Surg. 2005 Jul;130(1):146-50. PMID: 15999055. X-2, X-3, X-4 761. Masuda Y, Sekimoto M, Nambu M, et al. An unconstrained monitoring system for home rehabilitation. A wireless 772. Balachandran A, Shivbalan S, Thangavelu S. Chest heart/respiratory rate sensor accessible to home-visit therapists. physiotherapy in pediatric practice. Indian Pediatr. 2005 IEEE Eng Med Biol Mag. 2005 Jul-Aug;24(4):43-7. PMID: Jun;42(6):559-68. PMID: 15995272. X-1 16119212. X-1 773. Pons AR, Sauleda J, Noguera A, et al. Decreased 762. Di Mango AM, Lopes AJ, Jansen JM, et al. Changes in macrophage release of TGF-beta and TIMP-1 in chronic respiratory mechanics with increasing degrees of airway obstructive pulmonary disease. Eur Respir J. 2005 Jul;26(1):60- obstruction in COPD: detection by forced oscillation technique. 6. PMID: 15994390. X-2, X-3, X-4, X-5 Respir Med. 2006 Mar;100(3):399-410. PMID: 16115754. X-3, X-4, X-5 774. Newall C, Stockley RA, Hill SL. Exercise training and inspiratory muscle training in patients with bronchiectasis. 763. Nakatsuchi T, Otani M, Osugi H, et al. The necessity of Thorax. 2005 Nov;60(11):943-8. PMID: 15994254. X-2, X-3, chest physical therapy for thoracoscopic oesophagectomy. J Int X-4, X-5 Med Res. 2005 Jul-Aug;33(4):434-41. PMID: 16104447. X-2, X-4, X-6 775. Naylor JM, Chow CM, McLean AS, et al. Cardiovascular responses to short-term head-down positioning in healthy young 764. Windisch W, Kostic S, Dreher M, et al. Outcome of and older adults. Physiother Res Int. 2005;10(1):32-47. PMID: patients with stable COPD receiving controlled noninvasive 15991485. X-2, X-3, X-4, X-6 positive pressure ventilation aimed at a maximal reduction of Pa(CO2). Chest. 2005 Aug;128(2):657-62. PMID: 16100151. X- 776. Windisch W, Dreher M, Storre JH, et al. Nocturnal non- 3, X-4, X-5 invasive positive pressure ventilation: physiological effects on spontaneous breathing. Respir Physiol Neurobiol. 2006 Feb 765. van Rensen EL, Sont JK, Evertse CE, et al. Bronchial CD8 28;150(2-3):251-60. PMID: 15990366. X-2, X-3, X-4 cell infiltrate and lung function decline in asthma. Am J Respir Crit Care Med. 2005 Oct 1;172(7):837-41. PMID: 16085937. X- 777. Hunt A, Karela M, Robb PJ. Day-case adenoidectomy: 2, X-3, X-4, X-5 outcomes are improved using suction coagulation and prophylactic anti-emetic treatment. Int J Pediatr 766. Battisti A, Michotte JB, Tassaux D, et al. Non-invasive Otorhinolaryngol. 2005 Dec;69(12):1629-33. PMID: 15979161. ventilation in the recovery room for postoperative respiratory X-2, X-3, X-4, X-5 failure: a feasibility study. Swiss Med Wkly. 2005 Jun 11;135(23-24):339-43. PMID: 16059788. X-1 778. Kohler M, Clarenbach CF, Boni L, et al. Quality of life, physical disability, and respiratory impairment in Duchenne 767. Fowler R. King LT-D to the rescue. JEMS. 2005 muscular dystrophy. Am J Respir Crit Care Med. 2005 Oct Jul;30(7):90, 2. PMID: 16027669. X-1, X-2, X-3, X-4, X-5, X-6 15;172(8):1032-6. PMID: 15961695. X-3, X-4, X-5

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779. Lau HM, Lee EW, Wong CN, et al. The impact of severe 790. Trubel H, Banikol WK. Variability analysis of oscillatory acute respiratory syndrome on the physical profile and quality of airway resistance in children. Eur J Appl Physiol. 2005 life. Arch Phys Med Rehabil. 2005 Jun;86(6):1134-40. PMID: Jul;94(4):364-70. PMID: 15915353. X-2, X-3, X-4, X-5 15954051. X-2, X-3, X-4, X-5 791. de Oliveira LR, Albertini Yagi CS, Figueiredo AC, et al. 780. Sekine Y, Chiyo M, Iwata T, et al. Perioperative Short-term effects of nCPAP on nasal mucociliary clearance and rehabilitation and physiotherapy for lung cancer patients with mucus transportability in healthy subjects. Respir Med. 2006 chronic obstructive pulmonary disease. Jpn J Thorac Cardiovasc Jan;100(1):183-5. PMID: 15907380. X-2, X-3, X-4, X-5 Surg. 2005 May;53(5):237-43. PMID: 15952314. X-3, X-4 792. Fernandez-de-Las-Penas C, Alonso-Blanco C, Morales- 781. Broeders ME, Molema J, Hop WC, et al. Bronchial Cabezas M, et al. Two exercise interventions for the challenge, assessed with forced expiratory manoeuvres and management of patients with ankylosing spondylitis: a airway impedance. Respir Med. 2005 Aug;99(8):1046-52. randomized controlled trial. Am J Phys Med Rehabil. 2005 PMID: 15950147. X-2, X-3, X-4 Jun;84(6):407-19. PMID: 15905654. X-2, X-3, X-4

782. Lunn W, Feller-Kopman D, Wahidi M, et al. Endoscopic 793. Sohn K, Warwick WJ, Lee YW, et al. Investigation of non- removal of metallic airway stents. Chest. 2005 Jun;127(6):2106- uniform airflow signal oscillation during high frequency chest 12. PMID: 15947327. X-2, X-3, X-4 compression. Biomed Eng Online. 2005;4(1):34. PMID: 15904523. X-1 783. Asimakopoulos G, Beeson J, Evans J, et al. Cryosurgery for malignant endobronchial tumors: analysis of outcome. Chest. 794. Inal-Ince D, Savci S, Coplu L, et al. Factors determining 2005 Jun;127(6):2007-14. PMID: 15947313. X-2, X-3, X-4 self-efficacy in chronic obstructive pulmonary disease. Saudi Med J. 2005 Apr;26(4):542-7. PMID: 15900356. X-2, X-3, X-4, 784. Ko FW, Diba C, Roth M, et al. A comparison of airway and X-5 serum matrix metalloproteinase-9 activity among normal subjects, asthmatic patients, and patients with asthmatic mucus 795. Ward C, De Soyza A, Fisher AJ, et al. A descriptive study hypersecretion. Chest. 2005 Jun;127(6):1919-27. PMID: of small airway reticular basement membrane thickening in 15947303. X-2, X-3, X-4 clinically stable lung transplant recipients. J Heart Lung Transplant. 2005 May;24(5):533-7. PMID: 15896749. X-2, X-3, 785. Patterson JE, Bradley JM, Hewitt O, et al. Airway X-4 clearance in bronchiectasis: a randomized crossover trial of active cycle of breathing techniques versus Acapella. 796. Delclaux C, Zerah-Lancner F, Mahut B, et al. Alveolar Respiration. 2005 May-Jun;72(3):239-42. PMID: 15942291. X- nitric oxide and effect of deep inspiration during methacholine 5, X-6 challenge. Chest. 2005 May;127(5):1696-702. PMID: 15888848. X-2, X-3, X-4, X-5 786. Reardon CC, Christiansen D, Barnett ED, et al. Intrapulmonary percussive ventilation vs incentive spirometry 797. van den Toorn LM, Prins JB, de Jongste JC, et al. Benefit for children with neuromuscular disease. Arch Pediatr Adolesc from anti-inflammatory treatment during clinical remission of Med. 2005 Jun;159(6):526-31. PMID: 15939850. X-5 atopic asthma. Respir Med. 2005 Jun;99(6):779-87. PMID: 15878496. X-2, X-3, X-4, X-5 787. Duiverman ML, Bladder G, Meinesz AF, et al. Home mechanical ventilatory support in patients with restrictive ventilatory disorders: a 48-year experience. Respir Med. 2006 Jan;100(1):56-65. PMID: 15939581. X-2, X-3, X-5 798. Hsu LL, Batts BK, Rau JL. Positive expiratory pressure device acceptance by hospitalized children with sickle cell 788. Arjomandi M, Witten A, Abbritti E, et al. Repeated disease is comparable to incentive spirometry. Respir Care. 2005 exposure to ozone increases alveolar macrophage recruitment May;50(5):624-7. PMID: 15871756. X-2, X-3, X-4 into asthmatic airways. Am J Respir Crit Care Med. 2005 Aug 15;172(4):427-32. PMID: 15937293. X-2, X-3, X-4 799. D'Ovidio F, Mura M, Tsang M, et al. Bile acid aspiration and the development of bronchiolitis obliterans after lung 789. Kyle UG, Janssens JP, Rochat T, et al. Body composition transplantation. J Thorac Cardiovasc Surg. 2005 in patients with chronic hypercapnic respiratory failure. Respir May;129(5):1144-52. PMID: 15867792. X-2, X-3, X-4 Med. 2006 Feb;100(2):244-52. PMID: 15927457. X-2, X-3, X- 4, X-5 800. Kang SW, Kang YS, Moon JH, et al. Assisted cough and pulmonary compliance in patients with Duchenne muscular

Appendix-52 dystrophy. Yonsei Med J. 2005 Apr 30;46(2):233-8. PMID: Surg. 2005 Mar-Apr;20(2):142-6. PMID: 15725138. X-2, X-3, 15861496. X-3, X-4 X-4

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Appendix-54 tissue mechanics following surgical repair of congenital heart 856. Hemmila MR, Rowe SA, Boules TN, et al. Extracorporeal diseases. Pediatr Pulmonol. 2004 Dec;38(6):470-6. PMID: life support for severe acute respiratory distress syndrome in 15514973. X-2, X-3, X-4 adults. Ann Surg. 2004 Oct;240(4):595-605; discussion -7. PMID: 15383787. X-2, X-3, X-4 845. Sawy MS, Jayakrishnan B, Behbehani N, et al. Flexible fiberoptic bronchoscopy. Diagnostic yield. Saudi Med J. 2004 857. Faager G, Larsen FF. Performance changes for patients Oct;25(10):1459-63. PMID: 15494822. X-2, X-3, X-4 with chronic obstructive pulmonary disease on long-term oxygen therapy after physiotherapy. J Rehabil Med. 2004 846. Mandell DL, Yellon RF. Endoscopic KTP laser excision of Jul;36(4):153-8. PMID: 15370730. X-2, X-3, X-4, X-5 severe tracheotomy-associated suprastomal collapse. Int J Pediatr Otorhinolaryngol. 2004 Nov;68(11):1423-8. PMID: 858. Dutau H, Toutblanc B, Lamb C, et al. Use of the Dumon Y- 15488975. X-2, X-3, X-4 stent in the management of malignant disease involving the carina: a retrospective review of 86 patients. Chest. 2004 847. Chaboyer W, Gass E, Foster M. Patterns of chest Sep;126(3):951-8. PMID: 15364778. X-2, X-3, X-4 physiotherapy in Australian Intensive Care Units. J Crit Care. 2004 Sep;19(3):145-51. PMID: 15484174. X-1 859. Ioos C, Leclair-Richard D, Mrad S, et al. Respiratory capacity course in patients with infantile spinal muscular 848. Ip SP, Leung YF, Choy KL. Short-stay in-patient atrophy. Chest. 2004 Sep;126(3):831-7. PMID: 15364763. X-2, rehabilitation of elderly patients with chronic obstructive X-3, X-4 pulmonary disease: prospective study. Hong Kong Med J. 2004 Oct;10(5):312-8. PMID: 15479959. X-2, X-3, X-4 860. Winck JC, Goncalves MR, Lourenco C, et al. Effects of mechanical insufflation-exsufflation on respiratory parameters 849. Skowronski MD, Harris JG. Exploiting independent filter for patients with chronic airway secretion encumbrance. Chest. bandwidth of human factor cepstral coefficients in automatic 2004 Sep;126(3):774-80. PMID: 15364756. X-6 speech recognition. J Acoust Soc Am. 2004 Sep;116(3):1774- 80. PMID: 15478444. X-1 861. Ozdilekcan C, Songur N, Berktas BM, et al. Risk factors associated with postoperative pulmonary complications 850. Weiss HR. Rehabilitation of scoliosis patients with pain following oncological surgery. Tuberk Toraks. 2004;52(3):248- after surgery. Stud Health Technol Inform. 2002;88:250-3. 55. PMID: 15351938. X-2, X-3, X-4 PMID: 15456044. X-1 862. Sancho J, Servera E, Marin J, et al. Effect of lung 851. Sorin A, McCarthy JG, Bernstein JM. Predicting mechanics on mechanically assisted flows and volumes. Am J decannulation outcomes after distraction osteogenesis for Phys Med Rehabil. 2004 Sep;83(9):698-703. PMID: 15314534. syndromic micrognathia. Laryngoscope. 2004 X-2, X-3, X-4, X-5 Oct;114(10):1815-21. PMID: 15454778. X-2, X-3, X-4 863. Mayse ML, Greenheck J, Friedman M, et al. Successful 852. Kulik A, Ruel M, Bourke ME, et al. Postoperative bronchoscopic balloon dilation of nonmalignant naproxen after coronary artery bypass surgery: a double-blind tracheobronchial obstruction without fluoroscopy. Chest. 2004 randomized controlled trial. Eur J Cardiothorac Surg. 2004 Aug;126(2):634-7. PMID: 15302755. X-2, X-3, X-4 Oct;26(4):694-700. PMID: 15450559. X-2, X-3, X-4 864. Lehrer PM, Vaschillo E, Vaschillo B, et al. Biofeedback 853. Pontoppidan H. From continuous positive-pressure treatment for asthma. Chest. 2004 Aug;126(2):352-61. PMID: breathing to ventilator-induced lung injury. Anesthesiology. 15302717. X-2, X-3, X-4, X-5 2004 Oct;101(4):1015-7. PMID: 15448536. X-2, X-3, X-4 865. Turna A, Solak O, Cetinkaya E, et al. Lactate 854. Praetel C, Banner MJ, Monk T, et al. Isoflurane inhalation dehydrodgenase levels predict pulmonary morbidity after lung enhances increased physiologic deadspace volume associated resection for non-small cell lung cancer. Eur J Cardiothorac with positive pressure ventilation and compromises arterial Surg. 2004 Sep;26(3):483-7. PMID: 15302039. X-2, X-3, X-4 oxygenation. Anesth Analg. 2004 Oct;99(4):1107-13, table of contents. PMID: 15385359. X-2, X-3, X-4 866. Di Stefano A, Caramori G, Capelli A, et al. STAT4 activation in smokers and patients with chronic obstructive 855. Pasquina P, Merlani P, Granier JM, et al. Continuous pulmonary disease. Eur Respir J. 2004 Jul;24(1):78-85. PMID: positive airway pressure versus noninvasive pressure support 15293608. X-2, X-3, X-4 ventilation to treat atelectasis after cardiac surgery. Anesth Analg. 2004 Oct;99(4):1001-8, table of contents. PMID: 867. Bitzikas G, Didilis V, Mikroulis D, et al. Air-mattress 15385340. X-2, X-3, X-4 motion therapy for respiratory failure after cardiothoracic

Appendix-55 surgery. Surg Today. 2004;34(8):645-7. PMID: 15290391. X-2, and bronchoalveolar lavage profiles. J Investig Allergol Clin X-3, X-4 Immunol. 2004;14(1):26-33. PMID: 15160439. X-2, X-3, X-4, X-5 868. Shelledy DC, LeGrand TS, Peters JI. An assessment of the appropriateness of respiratory care delivered at a 450-bed acute 880. Zafiropoulos B, Alison JA, McCarren B. Physiological care Veterans affairs hospital. Respir Care. 2004 Aug;49(8):907- responses to the early mobilisation of the intubated, ventilated 16. PMID: 15271230. X-1, X-2, X-3, X-4, X-6 abdominal surgery patient. Aust J Physiother. 2004;50(2):95- 100. PMID: 15151493. X-2, X-3, X-4 869. Mandanmohan, Jatiya L, Udupa K, et al. Effect of yoga training on handgrip, respiratory pressures and pulmonary 881. Inal-Ince D, Savci S, Topeli A, et al. Active cycle of function. Indian J Physiol Pharmacol. 2003 Oct;47(4):387-92. breathing techniques in non-invasive ventilation for acute PMID: 15266949. X-2, X-3, X-4, X-5 hypercapnic respiratory failure. Aust J Physiother. 2004;50(2):67-73. PMID: 15151490. X-3 870. Sakamoto T, Nishio W, Okada M, et al. Management of air leak after pulmonary resection. Jpn J Thorac Cardiovasc Surg. 882. Miyazawa T, Miyazu Y, Iwamoto Y, et al. Stenting at the 2004 Jun;52(6):292-5. PMID: 15242082. X-2, X-3, X-4 flow-limiting segment in tracheobronchial stenosis due to lung cancer. Am J Respir Crit Care Med. 2004 May 871. Thill PJ, McGuire JK, Baden HP, et al. Noninvasive 15;169(10):1096-102. PMID: 15132959. X-2, X-3, X-4 positive-pressure ventilation in children with lower airway obstruction. Pediatr Crit Care Med. 2004 Jul;5(4):337-42. 883. Antonelli Incalzi R. Management of chronic obstructive PMID: 15215002. X-2, X-3, X-4 pulmonary disease in the elderly. Aging Clin Exp Res. 2004 Feb;16(1):13-21. PMID: 15132286. X-1 872. Tang LF, Du LZ, Chen ZM, et al. Extracellular matrix remodeling in children with airway foreign-body aspiration. 884. Walser EM, Robinson B, Raza SA, et al. Clinical outcomes Pediatr Pulmonol. 2004 Aug;38(2):140-5. PMID: 15211698. X- with airway stents for proximal versus distal malignant 2, X-3, X-4 tracheobronchial obstructions. J Vasc Interv Radiol. 2004 May;15(5):471-7. PMID: 15126657. X-2, X-3, X-4 873. Wenneberg S, Gunnarsson LG, Ahlstrom G. Using a novel exercise programme for patients with muscular dystrophy. Part 885. Dimauro S, Mancuso M, Naini A. Mitochondrial II: a quantitative study. Disabil Rehabil. 2004 May encephalomyopathies: therapeutic approach. Ann N Y Acad Sci. 20;26(10):595-602. PMID: 15204513. X-3, X-4, X-5 2004 Apr;1011:232-45. PMID: 15126300. X-1

874. Bourke SC, McColl E, Shaw PJ, et al. Validation of quality 886. Hetzel M, Hetzel J, Schumann C, et al. Cryorecanalization: of life instruments in ALS. Amyotroph Lateral Scler Other a new approach for the immediate management of acute airway Motor Neuron Disord. 2004 Mar;5(1):55-60. PMID: 15204025. obstruction. J Thorac Cardiovasc Surg. 2004 May;127(5):1427- X-3, X-4, X-5 31. PMID: 15116003. X-2, X-3, X-4

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985. Nauffal D, Domenech R, Martinez Garcia MA, et al. 996. Felekis VA. The suction mechanism as a factor in Noninvasive positive pressure home ventilation in restrictive intrathoracic oedema, connective tissue or pleural effusion. Med disorders: outcome and impact on health-related quality of life. Hypotheses. 2002 Oct;59(4):462-7. PMID: 12208189. X-1 Respir Med. 2002 Oct;96(10):777-83. PMID: 12412976. X-2, X-3, X-4, X-5 997. Goldman MD, Carter R, Klein R, et al. Within- and between-day variability of respiratory impedance, using impulse 986. Sharp HR, Hartley BE. KTP laser treatment of suprastomal oscillometry in adolescent asthmatics. Pediatr Pulmonol. 2002 obstruction prior to decannulation in paediatric tracheostomy. Oct;34(4):312-9. PMID: 12205573. X-2, X-3, X-4, X-5 Int J Pediatr Otorhinolaryngol. 2002 Nov 11;66(2):125-30. PMID: 12393245. X-2, X-3, X-4 998. Brimacombe J, Keller C, Brimacombe L. A comparison of the laryngeal mask airway ProSeal and the laryngeal tube airway 987. Trottier SJ, Ritter S, Lakshmanan R, et al. Percutaneous in paralyzed anesthetized adult patients undergoing pressure- tracheostomy tube obstruction: warning. Chest. 2002 controlled ventilation. Anesth Analg. 2002 Sep;95(3):770-6, Oct;122(4):1377-81. PMID: 12377868. X-2, X-3, X-4 table of contents. PMID: 12198070. X-2, X-3, X-4

988. Clini E, Sturani C, Rossi A, et al. The Italian multicentre 999. Windisch W, Vogel M, Sorichter S, et al. Normocapnia study on noninvasive ventilation in chronic obstructive during nIPPV in chronic hypercapnic COPD reduces subsequent pulmonary disease patients. Eur Respir J. 2002 Sep;20(3):529- spontaneous PaCO2. Respir Med. 2002 Aug;96(8):572-9. 38. PMID: 12358325. X-2, X-3, X-4, X-5 PMID: 12195837. X-2, X-3, X-4

989. Deakins K, Chatburn RL. A comparison of intrapulmonary 1000. Chalumeau M, Foix-L'Helias L, Scheinmann P, et al. Rib percussive ventilation and conventional chest physiotherapy for fractures after chest physiotherapy for bronchiolitis or the treatment of atelectasis in the pediatric patient. Respir Care. pneumonia in infants. Pediatr Radiol. 2002 Sep;32(9):644-7. 2002 Oct;47(10):1162-7. PMID: 12354335. X-4 PMID: 12195303. X-2, X-6

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1001. Hsu LH, Liu CC, Lin CY, et al. Self-expandable metallic 1012. Hila J, Ellis E, Holmes W. Feedback withdrawal and tracheobronchial stent insertion and endobronchial changing compliance during manual hyperinflation. Physiother electrocautery with flexible bronchoscopy: preliminary results at Res Int. 2002;7(2):53-64. PMID: 12109235. X-2, X-3, X-4, X-5 a cancer center. J Formos Med Assoc. 2002 Jun;101(6):399-405. PMID: 12189645. X-2, X-3, X-4 1013. Schweitzer C, Moreau-Colson C, Marchal F. Respiratory impedance response to a deep inhalation in asthmatic children 1002. Abdel-Rahman U, Ahrens P, Fieguth HG, et al. Surgical with spontaneous airway obstruction. Eur Respir J. 2002 treatment of tracheomalacia by bronchoscopic monitored Jun;19(6):1020-5. PMID: 12108851. X-2, X-3, X-4, X-5 aortopexy in infants and children. Ann Thorac Surg. 2002 Aug;74(2):315-9. PMID: 12173806. X-2, X-3, X-4 1014. Baudon JJ, Renault F, Goutet JM, et al. Motor dysfunction of the upper digestive tract in Pierre Robin sequence as assessed 1003. Gomez-Merino E, Sancho J, Marin J, et al. Mechanical by sucking-swallowing electromyography and esophageal insufflation-exsufflation: pressure, volume, and flow manometry. J Pediatr. 2002 Jun;140(6):719-23. PMID: relationships and the adequacy of the manufacturer's guidelines. 12072876. X-2, X-3, X-4 Am J Phys Med Rehabil. 2002 Aug;81(8):579-83. PMID: 12172066. X-2, X-3, X-4, X-5 1015. Turner P. Multidimensional scaling analysis of techniques used by physiotherapists in Southeast Australia: a cross-national 1004. Cahill P, Finan E, Loftus BG. Management of replication. Aust J Physiother. 2002;48(2):123-30. PMID: bronchiolitis: current practices in Ireland. Ir Med J. 2002 12047210. X-2, X-3, X-4, X-5 Jun;95(6):167-9. PMID: 12171262. X-2, X-3, X-4, X-5 1016. Faul JL, Demers EA, Burke CM, et al. Alterations in 1005. Romer LM, McConnell AK, Jones DA. Effects of airway inflammation and lung function during corticosteroid inspiratory muscle training on time-trial performance in trained therapy for atopic asthma. Chest. 2002 May;121(5):1414-20. cyclists. J Sports Sci. 2002 Jul;20(7):547-62. PMID: 12166881. PMID: 12006422. X-2, X-3, X-4, X-5 X-2, X-3, X-4, X-5 1017. Malmberg LP, Pelkonen A, Poussa T, et al. Determinants 1006. Kleinman BS, Frey K, VanDrunen M, et al. Motion of the of respiratory system input impedance and bronchodilator diaphragm in patients with chronic obstructive pulmonary response in healthy Finnish preschool children. Clin Physiol disease while spontaneously breathing versus during positive Funct Imaging. 2002 Jan;22(1):64-71. PMID: 12003103. X-2, pressure breathing after anesthesia and neuromuscular blockade. X-3, X-4, X-5 Anesthesiology. 2002 Aug;97(2):298-305. PMID: 12151916. X- 2, X-3, X-4, X-5 1018. Bassols A, Bosch F, Banos JE. How does the general population treat their pain? A survey in Catalonia, Spain. J Pain 1007. Hartung TK, Maulu A, Nash J, et al. Suspected pulmonary Symptom Manage. 2002 Apr;23(4):318-28. PMID: 11997201. tuberculosis in rural South Africa--sputum induction as a simple X-2, X-3, X-4, X-5 diagnostic tool? S Afr Med J. 2002 Jun;92(6):455-8. PMID: 12146131. X-2, X-3, X-4 1019. Tusman G, Bohm SH, Melkun F, et al. Alveolar recruitment strategy increases arterial oxygenation during one- 1008. Shimizu J, Watanabe Y, Oda M, et al. Evaluation of lung ventilation. Ann Thorac Surg. 2002 Apr;73(4):1204-9. sleeve segmentectomy for early hilar lung cancer. Int Surg. 2002 PMID: 11996264. X-2, X-3, X-4 Jan-Mar;87(1):53-9. PMID: 12144191. X-2, X-3, X-4, X-5 1020. Berney S, Stockton K, Berlowitz D, et al. Can early 1009. Winck JC, Delgado L, Vanzeller M, et al. Broncho- extubation and intensive physiotherapy decrease length of stay alveolar inflammation in cork worker's asthma. Allerg Immunol of acute quadriplegic patients in intensive care? A retrospective (Paris). 2002 Jun;34(6):199-203. PMID: 12134642. X-2, X-3, case control study. Physiother Res Int. 2002;7(1):14-22. PMID: X-4, X-5 11992981. X-2, X-3, X-4

1010. Wan IY, Lee TW, Lam HC, et al. Tracheobronchial 1021. Borm PJ, Jetten M, Hidayat S, et al. Respiratory stenting for tuberculous airway stenosis. Chest. 2002 symptoms, lung function, and nasal cellularity in Indonesian Jul;122(1):370-4. PMID: 12114385. X-2, X-3, X-4 wood workers: a dose-response analysis. Occup Environ Med. 2002 May;59(5):338-44. PMID: 11983850. X-2, X-3, X-4, X-5 1011. Karakoc F, Karadag B, Akbenlioglu C, et al. Foreign body aspiration: what is the outcome? Pediatr Pulmonol. 2002 1022. Thompson CS, Harrison S, Ashley J, et al. Randomised Jul;34(1):30-6. PMID: 12112794. X-2, X-3, X-4 crossover study of the Flutter device and the active cycle of breathing technique in non-cystic fibrosis bronchiectasis. Thorax. 2002 May;57(5):446-8. PMID: 11978924. X-5

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1023. Jouveshomme S, Fardeau C, Finet JF, et al. Alveolar 1034. Venn RM, Grounds RM. Comparison between lymphocytosis in patients with chronic uveitis: relationship to dexmedetomidine and propofol for sedation in the intensive care sarcoidosis. Lung. 2001;179(5):305-17. PMID: 11976898. X-2, unit: patient and clinician perceptions. Br J Anaesth. 2001 X-3, X-4, X-5 Nov;87(5):684-90. PMID: 11878517. X-2, X-3, X-4

1024. Al-Khafaji A, Manning HL. Inappropriate ventilator 1035. Karadag F, Ozhan MH, Akcicek E, et al. Is it possible to triggering caused by an in-line suction catheter. Intensive Care detect ulcerative colitis-related respiratory syndrome early? Med. 2002 Apr;28(4):515-9. PMID: 11967610. X-2, X-3, X-4, Respirology. 2001 Dec;6(4):341-6. PMID: 11844126. X-2, X-3, X-5 X-4, X-5

1025. Jevon P. Cardiopulmonary resuscitation. Airway 1036. Rigau J, Farre R, Roca J, et al. A portable forced management. Nurs Times. 2001 Oct 18-24;97(42):41-2. PMID: oscillation device for respiratory home monitoring. Eur Respir J. 11966126. X-1, X-2, X-3, X-4, X-5, X-6 2002 Jan;19(1):146-50. PMID: 11843313. X-2, X-3, X-4, X-5

1026. Tanaka H, Yukioka T, Yamaguti Y, et al. Surgical 1037. Janssens JP. When and how to assess quality of life in stabilization of internal pneumatic stabilization? A prospective chronic lung disease. Swiss Med Wkly. 2001 Nov 10;131(43- randomized study of management of severe flail chest patients. J 44):623-9. PMID: 11835109. X-1 Trauma. 2002 Apr;52(4):727-32; discussion 32. PMID: 11956391. X-2, X-3, X-4 1038. Brooks D, Parsons J, Newton J, et al. Discharge criteria from perioperative physical therapy. Chest. 2002 1027. Chhajed PN, Aboyoun C, Malouf MA, et al. Management Feb;121(2):488-94. PMID: 11834662. X-2, X-3, X-4, X-5 of acute hypoxemia during flexible bronchoscopy with insertion of a nasopharyngeal tube in lung transplant recipients. Chest. 1039. O'Neill B, Bradley JM, McArdle N, et al. The current 2002 Apr;121(4):1350-4. PMID: 11948074. X-2, X-3, X-4 physiotherapy management of patients with bronchiectasis: a UK survey. Int J Clin Pract. 2002 Jan-Feb;56(1):34-5. PMID: 1028. Morley R. Respiratory physiotherapy. Nurs Times. 2002 11831830. X-1 Mar 21-27;98(12):58-60. PMID: 11933787. X-1, X-2, X-3, X-4, X-5, X-6 1040. Saaresranta T, Polo-Kantola P, Rauhala E, et al. Medroxyprogesterone in postmenopausal females with partial 1029. Eltzschig HK, Posner M, Moore FD, Jr. The use of readily upper airway obstruction during sleep. Eur Respir J. 2001 available equipment in a simple method for intraoperative Dec;18(6):989-95. PMID: 11829107. X-2, X-3, X-4 monitoring of recurrent laryngeal nerve function during thyroid surgery: initial experience with more than 300 cases. Arch Surg. 1041. Ekatodramis G, Min K, Cathrein P, et al. Use of a double 2002 Apr;137(4):452-6; discussion 6-7. PMID: 11926951. X-2, epidural catheter provides effective postoperative analgesia after X-3, X-4 spine deformity surgery. Can J Anaesth. 2002 Feb;49(2):173-7. PMID: 11823396. X-2, X-3, X-4 1030. Ward C, Pais M, Bish R, et al. Airway inflammation, basement membrane thickening and bronchial 1042. Swift RD, Kiraly AP, Sherbondy AJ, et al. Automatic axis hyperresponsiveness in asthma. Thorax. 2002 Apr;57(4):309-16. generation for virtual bronchoscopic assessment of major airway PMID: 11923548. X-2, X-3, X-4, X-5 obstructions. Comput Med Imaging Graph. 2002 Mar- Apr;26(2):103-18. PMID: 11818189. X-1 1031. Valentine VG, Taylor DE, Dhillon GS, et al. Success of lung transplantation without surveillance bronchoscopy. J Heart 1043. Walker P. Pediatric adenoidectomy under vision using Lung Transplant. 2002 Mar;21(3):319-26. PMID: 11897519. X- suction-diathermy ablation. Laryngoscope. 2001 2, X-3, X-4 Dec;111(12):2173-7. PMID: 11802020. X-2, X-3, X-4

1032. Wolkove N, Kamel H, Rotaple M, et al. Use of a mucus 1044. Chen D, Han L, Hu Y, et al. Diagnosis and treatment of clearance device enhances the bronchodilator response in bronchial rupture from blunt thoracic trauma. Chin Med J patients with stable COPD. Chest. 2002 Mar;121(3):702-7. (Engl). 2001 May;114(5):540-1. PMID: 11780422. X-2, X-3, X- PMID: 11888949. X-2, X-4, X-5, X-6 4

1033. Boisseau N, Rabary O, Padovani B, et al. Improvement of 1045. Hotchkiss JR, Jr., Adams AB, Stone MK, et al. 'dynamic analgesia' does not decrease atelectasis after Oscillations and noise: inherent instability of pressure support thoracotomy. Br J Anaesth. 2001 Oct;87(4):564-9. PMID: ventilation? Am J Respir Crit Care Med. 2002 Jan 1;165(1):47- 11878725. X-2, X-3, X-4 53. PMID: 11779729. X-1

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1046. Suzuki R, Freed AN. Heparin inhibits hyperventilation- 1057. Kim CW, Kim JS, Park JW, et al. Clinical applications of induced late-phase hyperreactivity in dogs. Am J Respir Crit forced oscillation techniques (FOT) in patients with bronchial Care Med. 2002 Jan 1;165(1):27-33. PMID: 11779726. X-1 asthma. Korean J Intern Med. 2001 Jun;16(2):80-6. PMID: 11590906. X-2, X-3 1047. Pifferi M, Cangiotti AM, Ragazzo V, et al. Primary ciliary dyskinesia: diagnosis in children with inconclusive 1058. Delacourt C, Lorino H, Fuhrman C, et al. Comparison of ultrastructural evaluation. Pediatr Allergy Immunol. 2001 the forced oscillation technique and the interrupter technique for Oct;12(5):274-82. PMID: 11737674. X-1 assessing airway obstruction and its reversibility in children. Am J Respir Crit Care Med. 2001 Sep 15;164(6):965-72. PMID: 1048. Schonhofer B, Von Sydow K, Bucher T, et al. Sexuality in 11587980. X-2, X-3 patients with noninvasive mechanical ventilation due to chronic respiratory failure. Am J Respir Crit Care Med. 2001 Nov 1059. Reber A, Paganoni R, Frei FJ. Effect of common airway 1;164(9):1612-7. PMID: 11719298. X-2, X-3, X-4 manoeuvres on upper airway dimensions and clinical signs in anaesthetized, spontaneously breathing children. Br J Anaesth. 1049. John M, Fietze I, Borges AC, et al. Quantification of the 2001 Feb;86(2):217-22. PMID: 11573663. X-2, X-3, X-4 effect of inhaled budesonide on airway inflammation in intermittent asthma by bronchitis index. J Asthma. 2001 1060. Goodchild CS, Robinson A, Nadeson R. Antinociceptive Oct;38(7):593-9. PMID: 11714082. X-2, X-3, X-4, X-5 properties of neurosteroids IV: pilot study demonstrating the analgesic effects of alphadolone administered orally to humans. 1050. Mohr AM, Rutherford EJ, Cairns BA, et al. The role of Br J Anaesth. 2001 Apr;86(4):528-34. PMID: 11573627. X-2, dead space ventilation in predicting outcome of successful X-3, X-4, X-5 weaning from mechanical ventilation. J Trauma. 2001 Nov;51(5):843-8. PMID: 11706329. X-2, X-3 1061. Klefbeck B, Svartengren K, Camner P, et al. Lung clearance in children with Duchenne muscular dystrophy or 1051. Hall GL, Hantos Z, Sly PD. Altered respiratory tissue spinal muscular atrophy with and without CPAP (continuous mechanics in asymptomatic wheezy infants. Am J Respir Crit positive airway pressure). Exp Lung Res. 2001 Sep;27(6):469- Care Med. 2001 Oct 15;164(8 Pt 1):1387-91. PMID: 11704583. 84. PMID: 11558965. X-2, X-3, X-4, X-5, X-6 X-2, X-3 1062. Pelosi P, Chiumello D, Calvi E, et al. Effects of different 1052. Farias JA, Retta A, Alia I, et al. A comparison of two continuous positive airway pressure devices and periodic methods to perform a breathing trial before extubation in hyperinflations on respiratory function. Crit Care Med. 2001 pediatric intensive care patients. Intensive Care Med. 2001 Sep;29(9):1683-9. PMID: 11546965. X-2, X-3, X-4, X-6 Oct;27(10):1649-54. PMID: 11685307. X-2, X-3, X-4 1063. Nielsen KG, Bisgaard H. Discriminative capacity of 1053. Nava S, Karakurt S, Rampulla C, et al. Salbutamol bronchodilator response measured with three different lung delivery during non-invasive mechanical ventilation in patients function techniques in asthmatic and healthy children aged 2 to with chronic obstructive pulmonary disease: a randomized, 5 years. Am J Respir Crit Care Med. 2001 Aug 15;164(4):554-9. controlled study. Intensive Care Med. 2001 Oct;27(10):1627-35. PMID: 11520714. X-2, X-3, X-4, X-5 PMID: 11685304. X-2, X-3 1064. van Veldhoven NH, Vermeer A, Bogaard JM, et al. 1054. Jackson CE, Rosenfeld J, Moore DH, et al. A preliminary Children with asthma and physical exercise: effects of an evaluation of a prospective study of pulmonary function studies exercise programme. Clin Rehabil. 2001 Aug;15(4):360-70. and symptoms of hypoventilation in ALS/MND patients. J PMID: 11518437. X-2, X-3, X-4, X-5 Neurol Sci. 2001 Oct 15;191(1-2):75-8. PMID: 11676995. X-3 1065. Covey MK, Larson JL, Wirtz SE, et al. High-intensity 1055. Stewart H, Eisen A, Road J, et al. Electromyography of inspiratory muscle training in patients with chronic obstructive respiratory muscles in amyotrophic lateral sclerosis. J Neurol pulmonary disease and severely reduced function. J Cardiopulm Sci. 2001 Oct 15;191(1-2):67-73. PMID: 11676994. X-3 Rehabil. 2001 Jul-Aug;21(4):231-40. PMID: 11508185. X-2, X- 4, X-5 1056. Mudway IS, Stenfors N, Blomberg A, et al. Differences in basal airway antioxidant concentrations are not predictive of 1066. Miller PR, Croce MA, Bee TK, et al. ARDS after individual responsiveness to ozone: a comparison of healthy and pulmonary contusion: accurate measurement of contusion mild asthmatic subjects. Free Radic Biol Med. 2001 Oct volume identifies high-risk patients. J Trauma. 2001 15;31(8):962-74. PMID: 11595381. X-1 Aug;51(2):223-8; discussion 9-30. PMID: 11493778. X-2, X-3, X-4

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1067. Reber A, Bobbia SA, Hammer J, et al. Effect of airway fluoroscopy. Chest. 2001 Jun;119(6):1910-2. PMID: 11399723. opening manoeuvres on thoraco-abdominal asynchrony in X-2, X-3, X-4 anaesthetized children. Eur Respir J. 2001 Jun;17(6):1239-43. PMID: 11491171. X-2, X-3, X-4, X-5 1079. Ekberg-Jansson A, Andersson B, Bake B, et al. Neutrophil-associated activation markers in healthy smokers 1068. Westerdahl E, Lindmark B, Almgren SO, et al. Chest relates to a fall in DL(CO) and to emphysematous changes on physiotherapy after coronary artery bypass graft surgery--a high resolution CT. Respir Med. 2001 May;95(5):363-73. comparison of three different deep breathing techniques. J PMID: 11392577. X-2, X-3, X-4, X-5 Rehabil Med. 2001 Mar;33(2):79-84. PMID: 11474953. X-2, X- 3, X-4 1080. Macsween A, Johnson NJ, Armstrong G, et al. A validation of the 10-meter incremental shuttle walk test as a 1069. Wetter TJ, St Croix CM, Pegelow DF, et al. Effects of measure of aerobic power in cardiac and rheumatoid arthritis exhaustive endurance exercise on pulmonary gas exchange and patients. Arch Phys Med Rehabil. 2001 Jun;82(6):807-10. airway function in women. J Appl Physiol. 2001 Aug;91(2):847- PMID: 11387587. X-2, X-3, X-4, X-5 58. PMID: 11457802. X-2, X-3, X-4, X-5 1081. Okada S, Ishimori S, Sato M, et al. Endoscopic surgery 1070. Tsai CF, Tsai JJ. Effectiveness of a positive expiratory with use of a laryngeal mask and a fiberoptic flexible pressure device in conjunction with beta2-agonist nebulization bronchoscope. J Thorac Cardiovasc Surg. 2001 therapy for bronchial asthma. J Microbiol Immunol Infect. 2001 Jun;121(6):1196-7. PMID: 11385389. X-2, X-3, X-4 Jun;34(2):92-6. PMID: 11456366. X-2, X-3, X-4, X-5 1082. Takizawa H, Tanaka M, Takami K, et al. Increased 1071. Patman S, Jenkins S, Smith K. Manual hyperinflation: expression of transforming growth factor-beta1 in small airway consistency and modification of the technique by epithelium from tobacco smokers and patients with chronic physiotherapists. Physiother Res Int. 2001;6(2):106-17. PMID: obstructive pulmonary disease (COPD). Am J Respir Crit Care 11436671. X-2, X-3, X-4, X-5 Med. 2001 May;163(6):1476-83. PMID: 11371421. X-2, X-3, X-4, X-5 1072. Dhole S, Mehta Y, Saxena H, et al. Comparison of continuous thoracic epidural and paravertebral blocks for 1083. Athanassiadi K, Kalavrouziotis G, Karydakis K, et al. postoperative analgesia after minimally invasive direct coronary Treatment of thoracic outlet syndrome: long-term results. World artery bypass surgery. J Cardiothorac Vasc Anesth. 2001 J Surg. 2001 May;25(5):553-7. PMID: 11369978. X-2, X-3, X- Jun;15(3):288-92. PMID: 11426357. X-2, X-3, X-4 4, X-5

1073. Prieto D, Bernardo J, Matos MJ, et al. Surgery for 1084. Sivasothy P, Brown L, Smith IE, et al. Effect of manually bronchiectasis. Eur J Cardiothorac Surg. 2001 Jul;20(1):19-23, assisted cough and mechanical insufflation on cough flow of discussion -4. PMID: 11423268. X-2, X-3 normal subjects, patients with chronic obstructive pulmonary disease (COPD), and patients with respiratory muscle weakness. 1074. Ishikawa S, Ohtaki A, Takahashi T, et al. PEEP therapy Thorax. 2001 Jun;56(6):438-44. PMID: 11359958. X-5, X-6 for patients with pleurotomy during coronary artery bypass grafting. J Card Surg. 2000 May-Jun;15(3):175-8. PMID: 1085. Aboussouan LS, Khan SU, Banerjee M, et al. Objective 11414602. X-2, X-3, X-4, X-5 measures of the efficacy of noninvasive positive-pressure ventilation in amyotrophic lateral sclerosis. Muscle Nerve. 2001 1075. Kabra SK, Lodha R, Singhal T. Chronic obstructive Mar;24(3):403-9. PMID: 11353427. X-2, X-3, X-4, X-5 pulmonary disease in children. Indian J Pediatr. 2001 Apr;68 Suppl 2:S50-4. PMID: 11411378. X-1 1086. Park C, Bahk JH, Ahn WS, et al. The laryngeal mask airway in infants and children. Can J Anaesth. 2001 1076. Chugh K. Clinical approach to a patient with cough. Apr;48(4):413-7. PMID: 11339788. X-2, X-3, X-4, X-5 Indian J Pediatr. 2001 Apr;68 Suppl 2:S11-9. PMID: 11411372. X-1 1087. Kaczka DW, Ingenito EP, Body SC, et al. Inspiratory lung impedance in COPD: effects of PEEP and immediate impact of 1077. Birch M, MacLeod D, Levine M. An analogue instrument lung volume reduction surgery. J Appl Physiol. 2001 for the measurement of respiratory impedance using the forced May;90(5):1833-41. PMID: 11299274. X-2, X-3, X-4 oscillation technique. Physiol Meas. 2001 May;22(2):323-39. PMID: 11411243. X-1 1088. Davis K, Jr., Johannigman JA, Campbell RS, et al. The acute effects of body position strategies and respiratory therapy 1078. Herth F, Becker HD, LoCicero J, 3rd, et al. Successful in paralyzed patients with acute lung injury. Crit Care. bronchoscopic placement of tracheobronchial stents without 2001;5(2):81-7. PMID: 11299066. X-3

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1089. Lorenz IH, Kolbitsch C, Hormann C, et al. Increasing 1100. Osunsanya T, Prescott G, Seaton A. Acute respiratory mean airway pressure reduces functional MRI (fMRI) signal in effects of particles: mass or number? Occup Environ Med. 2001 the primary visual cortex. Magn Reson Imaging. 2001 Mar;58(3):154-9. PMID: 11171927. X-2, X-3, X-4, X-5 Jan;19(1):7-11. PMID: 11295340. X-2, X-3, X-4, X-5 1101. Gosselink R, Schrever K, Cops P, et al. Incentive 1090. Buchner AM, Sonnenberg A. Medical diagnoses and spirometry does not enhance recovery after thoracic surgery. procedures associated with clostridium difficile colitis. Am J Crit Care Med. 2000 Mar;28(3):679-83. PMID: 10752814. X-2, Gastroenterol. 2001 Mar;96(3):766-72. PMID: 11280548. X-2, X-3, X-4, X-5 X-3, X-4, X-5 1102. Wrigge H, Zinserling J, Stuber F, et al. Effects of 1091. Kriebel D, Myers D, Cheng M, et al. Short-term effects of mechanical ventilation on release of cytokines into systemic formaldehyde on peak expiratory flow and irritant symptoms. circulation in patients with normal pulmonary function. Arch Environ Health. 2001 Jan-Feb;56(1):11-8. PMID: Anesthesiology. 2000 Dec;93(6):1413-7. PMID: 11149435. X-2, 11256851. X-2, X-3, X-4, X-5 X-3, X-4

1092. Morice RC, Ece T, Ece F, et al. Endobronchial argon 1103. Ritz T, Steptoe A. Emotion and pulmonary function in plasma coagulation for treatment of hemoptysis and neoplastic asthma: reactivity in the field and relationship with laboratory airway obstruction. Chest. 2001 Mar;119(3):781-7. PMID: induction of emotion. Psychosom Med. 2000 Nov- 11243957. X-2, X-3, X-4, X-5 Dec;62(6):808-15. PMID: 11139001. X-2, X-3, X-4, X-5

1093. Fuwa N, Matsumoto A, Kamata M, et al. External 1104. Hall GL, Hantos Z, Wildhaber JH, et al. Methacholine irradiation and intraluminal irradiation using middle-dose-rate responsiveness in infants assessed with low frequency forced iridium in patients with roentgenographically occult lung cancer. oscillation and forced expiration techniques. Thorax. 2001 Int J Radiat Oncol Biol Phys. 2001 Mar 15;49(4):965-71. PMID: Jan;56(1):42-7. PMID: 11120903. X-2, X-3, X-4 11240237. X-2, X-3, X-4, X-5 1105. Tan HK, Brown K, McGill T, et al. Airway foreign bodies 1094. Verbraak AF, Rijnbeek PR, Beneken JE, et al. A new (FB): a 10-year review. Int J Pediatr Otorhinolaryngol. 2000 approach to mechanical simulation of lung behaviour: pressure- Dec 1;56(2):91-9. PMID: 11115682. X-2, X-3, X-4 controlled and time-related piston movement. Med Biol Eng Comput. 2001 Jan;39(1):82-9. PMID: 11214278. X-1 1106. Casanova C, Celli BR, Tost L, et al. Long-term controlled trial of nocturnal nasal positive pressure ventilation in patients 1095. Tanaka H, Tajimi K, Endoh Y, et al. Pneumatic with severe COPD. Chest. 2000 Dec;118(6):1582-90. PMID: stabilization for flail chest injury: an 11-year study. Surg Today. 11115443. X-2, X-3, X-4, X-5 2001;31(1):12-7. PMID: 11213036. X-2, X-3, X-4, X-5 1107. Chalut DS, Ducharme FM, Davis GM. The Preschool 1096. Sathyaprabha TN, Murthy H, Murthy BT. Efficacy of Respiratory Assessment Measure (PRAM): a responsive index naturopathy and yoga in bronchial asthma--a self controlled of acute asthma severity. J Pediatr. 2000 Dec;137(6):762-8. matched scientific study. Indian J Physiol Pharmacol. 2001 PMID: 11113831. X-2, X-3, X-4, X-5 Jan;45(1):80-6. PMID: 11211575. X-2, X-3, X-4, X-5 1108. Navajas D, Alcaraz J, Peslin R, et al. Evaluation of a 1097. Linden V, Palmer K, Reinhard J, et al. High survival in method for assessing respiratory mechanics during noninvasive adult patients with acute respiratory distress syndrome treated by ventilation. Eur Respir J. 2000 Oct;16(4):704-9. PMID: extracorporeal membrane oxygenation, minimal sedation, and 11106216. X-2, X-3, X-4, X-5 pressure supported ventilation. Intensive Care Med. 2000 Nov;26(11):1630-7. PMID: 11193269. X-2, X-3, X-4, X-5 1109. Biro P, Layer M, Becker HD, et al. Influence of airway- occluding instruments on airway pressure during jet ventilation 1098. Lee JH, Chung HS. Bronchoscopic, radiologic and for rigid bronchoscopy. Br J Anaesth. 2000 Sep;85(3):462-5. pulmonary function evaluation of endobronchial tuberculosis. PMID: 11103191. X-2, X-3, X-4 Respirology. 2000 Dec;5(4):411-7. PMID: 11192556. X-2, X-3, X-4, X-5 1110. Kostianev S, Liistro G, Veriter C, et al. Effect of CPAP on breathlessness perception in healthy subjects during 1099. Green RH, Singh SJ, Williams J, et al. A randomised methacholine induced bronchoconstriction. Acta Physiol controlled trial of four weeks versus seven weeks of pulmonary Pharmacol Bulg. 1999;24(4):113-8. PMID: 11098298. X-2, X-3, rehabilitation in chronic obstructive pulmonary disease. Thorax. X-4, X-5 2001 Feb;56(2):143-5. PMID: 11209104. X-2, X-3, X-4, X-5

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1111. Menzies D, Fanning A, Yuan L, et al. Hospital ventilation ventilation. Intensive Care Med. 2000 Aug;26(8):1057-64. and risk for tuberculous infection in canadian health care PMID: 11030161. X-2, X-3, X-4 workers. Canadian Collaborative Group in Nosocomial Transmission of TB. Ann Intern Med. 2000 Nov 1122. Nielsen KG, Bisgaard H. The effect of inhaled budesonide 21;133(10):779-89. PMID: 11085840. X-2, X-3, X-4, X-5 on symptoms, lung function, and cold air and methacholine responsiveness in 2- to 5-year-old asthmatic children. Am J 1112. Matsuo T, Colt HG. Evidence against routine scheduling Respir Crit Care Med. 2000 Oct;162(4 Pt 1):1500-6. PMID: of surveillance bronchoscopy after stent insertion. Chest. 2000 11029368. X-2, X-3, X-4, X-5 Nov;118(5):1455-9. PMID: 11083701. X-2, X-3, X-4 1123. Yap JC, Moore DM, Cleland JG, et al. Effect of supine 1113. Vitacca M, Nava S, Confalonieri M, et al. The appropriate posture on respiratory mechanics in chronic left ventricular setting of noninvasive pressure support ventilation in stable failure. Am J Respir Crit Care Med. 2000 Oct;162(4 Pt 1):1285- COPD patients. Chest. 2000 Nov;118(5):1286-93. PMID: 91. PMID: 11029332. X-2, X-3, X-4, X-5 11083676. X-2, X-3, X-4, X-5 1124. Tenling A, Joachimsson PO, Tyden H, et al. Thoracic 1114. Schulze-Neick I, Ho SY, Bush A, et al. Severe airflow epidural analgesia as an adjunct to general anaesthesia for limitation after the unifocalization procedure: clinical and cardiac surgery. Effects on pulmonary mechanics. Acta morphological correlates. Circulation. 2000 Nov 7;102(19 Suppl Anaesthesiol Scand. 2000 Oct;44(9):1071-6. PMID: 11028725. 3):III142-7. PMID: 11082377. X-2, X-3, X-4 X-2, X-3, X-4, X-5

1115. Riedel M, Stein HJ, Mounyam L, et al. Influence of 1125. Klug B, Nielsen KG, Bisgaard H. Observer variability of simultaneous neoadjuvant radiotherapy and chemotherapy on lung function measurements in 2-6-yr-old children. Eur Respir J. bronchoscopic findings and lung function in patients with 2000 Sep;16(3):472-5. PMID: 11028662. X-2, X-3, X-4, X-5 locally advanced proximal esophageal cancer. Am J Respir Crit Care Med. 2000 Nov;162(5):1741-6. PMID: 11069806. X-2, X- 1126. Tanigawa N, Sawada S, Okuda Y, et al. Symptomatic 3, X-4 improvement in dyspnea following tracheobronchial metallic stenting for malignant airway obstruction. Acta Radiol. 2000 1116. Putinati S, Ballerin L, Piattella M, et al. Is it possible to Sep;41(5):425-8. PMID: 11016759. X-2, X-3, X-4 predict the success of non-invasive positive pressure ventilation in acute respiratory failure due to COPD? Respir Med. 2000 1127. . Medical devices; effective date of requirement for Oct;94(10):997-1001. PMID: 11059955. X-2, X-3, X-4 premarket approval for three preamendment class III devices. Food and Drug Administration, HHS. Final rule. Fed Regist. 1117. Schoenmakers MA, Gulmans VA, Bax NM, et al. 2000 Apr 13;65(72):19833-4. PMID: 11010634. X-1 Physiotherapy as an adjuvant to the surgical treatment of anterior chest wall deformities: a necessity? A prospective 1128. Norrenberg M, Vincent JL. A profile of European descriptive study in 21 patients. J Pediatr Surg. 2000 intensive care unit physiotherapists. European Society of Oct;35(10):1440-3. PMID: 11051146. X-2, X-3, X-4, X-5 Intensive Care Medicine. Intensive Care Med. 2000 Jul;26(7):988-94. PMID: 10990117. X-2, X-3, X-4, X-5 1118. Nava S, Compagnoni ML. Controlled short-term trial of fluticasone propionate in ventilator-dependent patients with 1129. Deslee G, Brichet A, Lebuffe G, et al. Obstructive COPD. Chest. 2000 Oct;118(4):990-9. PMID: 11035668. X-2, fibrinous tracheal pseudomembrane. A potentially fatal X-3, X-4 complication of tracheal intubation. Am J Respir Crit Care Med. 2000 Sep;162(3 Pt 1):1169-71. PMID: 10988148. X-2, X-3, X-4 1119. Weill D, Mack M, Roth J, et al. Adenoviral-mediated p53 gene transfer to non-small cell lung cancer through 1130. Yu HR, Niu CK, Su YT, et al. Flexible bronchoscopic endobronchial injection. Chest. 2000 Oct;118(4):966-70. PMID: diagnosis of airway injuries after intubation in children. J 11035664. X-1 Formos Med Assoc. 2000 Aug;99(8):618-22. PMID: 10969504. X-2, X-3, X-4 1120. Miyazawa T, Yamakido M, Ikeda S, et al. Implantation of ultraflex nitinol stents in malignant tracheobronchial stenoses. 1131. Umesaki N, Tanaka T, Miyama M, et al. Effect of Chest. 2000 Oct;118(4):959-65. PMID: 11035663. X-2, X-3, X- adjuvant chemotherapy using pirarubicin, cisplatin, and 4 etoposide (PEP) for stage IVB endometrial carcinoma: a case report. Eur J Gynaecol Oncol. 2000;21(3):303-4. PMID: 1121. Vassiliou MP, Petri L, Amygdalou A, et al. Linear and 10949401. X-1 nonlinear analysis of pressure and flow during mechanical

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1132. Coulter TD, Mehta AC. The heat is on: impact of 1143. Ekberg-Jansson A, Andersson B, Avra E, et al. The endobronchial electrosurgery on the need for Nd-YAG laser expression of lymphocyte surface antigens in bronchial biopsies, photoresection. Chest. 2000 Aug;118(2):516-21. PMID: bronchoalveolar lavage cells and blood cells in healthy smoking 10936149. X-2, X-3, X-4, X-5 and never-smoking men, 60 years old. Respir Med. 2000 Mar;94(3):264-72. PMID: 10783938. X-2, X-3, X-4, X-5 1133. Garstang SV, Kirshblum SC, Wood KE. Patient preference for in-exsufflation for secretion management with 1144. Campbell RS, Davis K, Jr., Johannigman JA, et al. The spinal cord injury. J Spinal Cord Med. 2000 Summer;23(2):80- effects of passive humidifier dead space on respiratory variables 5. PMID: 10914345. X-4, X-6 in paralyzed and spontaneously breathing patients. Respir Care. 2000 Mar;45(3):306-12. PMID: 10771799. X-2, X-3, X-4, X-5 1134. Szalados JE, Noe FE, Busby MG, et al. Single-breath measurements of pulmonary oxygen uptake and gas flow rates 1145. O'Regan A, Fenlon HM, Beamis JF, Jr., et al. for ventilator management in ARDS. Chest. 2000 Tracheobronchial amyloidosis. The Boston University Jun;117(6):1805-9. PMID: 10858423. X-1 experience from 1984 to 1999. Medicine (Baltimore). 2000 Mar;79(2):69-79. PMID: 10771705. X-2, X-3, X-4, X-5 1135. Liaw MY, Lin MC, Cheng PT, et al. Resistive inspiratory muscle training: its effectiveness in patients with acute complete 1146. Ugalde V, Breslin EH, Walsh SA, et al. Pursed lips cervical cord injury. Arch Phys Med Rehabil. 2000 breathing improves ventilation in myotonic muscular dystrophy. Jun;81(6):752-6. PMID: 10857519. X-2, X-3, X-4 Arch Phys Med Rehabil. 2000 Apr;81(4):472-8. PMID: 10768538. X-2, X-3, X-4, X-5, X-6 1136. Gosselink R, Kovacs L, Ketelaer P, et al. Respiratory muscle weakness and respiratory muscle training in severely 1147. Shorr AF, Hnatiuk OW. Circulating D dimer in patients disabled multiple sclerosis patients. Arch Phys Med Rehabil. with sarcoidosis. Chest. 2000 Apr;117(4):1012-6. PMID: 2000 Jun;81(6):747-51. PMID: 10857518. X-3, X-5 10767232. X-2, X-3, X-4, X-5

1137. Hodgson C, Denehy L, Ntoumenopoulos G, et al. An 1148. Guell R, Casan P, Belda J, et al. Long-term effects of investigation of the early effects of manual lung hyperinflation outpatient rehabilitation of COPD: A randomized trial. Chest. in critically ill patients. Anaesth Intensive Care. 2000 2000 Apr;117(4):976-83. PMID: 10767227. X-3, X-4, X-5 Jun;28(3):255-61. PMID: 10853205. X-3, X-6 1149. Bingol Karakoc G, Yilmaz M, Sur S, et al. The effects of 1138. Nielsen KG, Bisgaard H. Lung function response to cold daily pulmonary rehabilitation program at home on childhood air challenge in asthmatic and healthy children of 2-5 years of asthma. Allergol Immunopathol (Madr). 2000 Jan-Feb;28(1):12- age. Am J Respir Crit Care Med. 2000 Jun;161(6):1805-9. 4. PMID: 10757852. X-5 PMID: 10852748. X-2, X-3, X-4, X-5 1150. Lo CP, Hsu AA, Eng P. Endobronchial stenting in patients 1139. Biro P, Layer M, Wiedemann K, et al. Carbon dioxide requiring mechanical ventilation for major airway obstruction. elimination during high-frequency jet ventilation for rigid Ann Acad Med Singapore. 2000 Jan;29(1):66-70. PMID: bronchoscopy. Br J Anaesth. 2000 May;84(5):635-7. PMID: 10748968. X-2, X-3, X-4 10844843. X-2, X-3, X-4 1151. Malki D, Quine SM, Pfleiderer AG. Nasal splints, 1140. Annane D, Quera-Salva MA, Lofaso F, et al. Mechanisms revisited. J Laryngol Otol. 1999 Aug;113(8):725-7. PMID: underlying effects of nocturnal ventilation on daytime blood 10748847. X-2, X-3, X-4 gases in neuromuscular diseases. Eur Respir J. 1999 Jan;13(1):157-62. PMID: 10836341. X-3, X-5 1152. Kurabayashi H, Machida I, Tamura K, et al. Breathing out into water during subtotal immersion: a therapy for chronic 1141. Heikkila S, Viitanen JV, Kautiainen H, et al. Sensitivity to pulmonary emphysema. Am J Phys Med Rehabil. 2000 Mar- change of mobility tests; effect of short term intensive Apr;79(2):150-3. PMID: 10744189. X-2, X-3, X-4, X-5 physiotherapy and exercise on spinal, hip, and shoulder measurements in spondyloarthropathy. J Rheumatol. 2000 1153. Ringbaek TJ, Broendum E, Hemmingsen L, et al. May;27(5):1251-6. PMID: 10813296. X-2, X-3, X-4, X-5 Rehabilitation of patients with chronic obstructive pulmonary disease. Exercise twice a week is not sufficient! Respir Med. 1142. Bellone A, Lascioli R, Raschi S, et al. Chest physical 2000 Feb;94(2):150-4. PMID: 10714421. X-2, X-3, X-4, X-5 therapy in patients with acute exacerbation of chronic bronchitis: effectiveness of three methods. Arch Phys Med Rehabil. 2000 1154. Weiner P, Berar-Yanay N, Davidovich A, et al. Specific May;81(5):558-60. PMID: 10807091. X-5 inspiratory muscle training in patients with mild asthma with

Appendix-68 high consumption of inhaled beta(2)-agonists. Chest. 2000 1165. Stephens KE, Jr., Wood DE. Bronchoscopic management Mar;117(3):722-7. PMID: 10712997. X-2, X-3, X-4, X-5 of central airway obstruction. J Thorac Cardiovasc Surg. 2000 Feb;119(2):289-96. PMID: 10649204. X-2, X-3, X-4 1155. Delacourt C, Lorino H, Herve-Guillot M, et al. Use of the forced oscillation technique to assess airway obstruction and 1166. Stayer SA, Bent ST, Campos CJ, et al. Comparison of reversibility in children. Am J Respir Crit Care Med. 2000 NAD 6000 and servo 900C ventilators in an infant lung model. Mar;161(3 Pt 1):730-6. PMID: 10712315. X-2, X-3, X-4, X-5 Anesth Analg. 2000 Feb;90(2):315-21. PMID: 10648313. X-1

1156. Chowbey PK, Sharma A, Khullar R, et al. Laparoscopic 1167. Burke AJ, Vining DJ, McGuirt WF, Jr., et al. Evaluation subtotal cholecystectomy: a review of 56 procedures. J of airway obstruction using virtual endoscopy. Laryngoscope. Laparoendosc Adv Surg Tech A. 2000 Feb;10(1):31-4. PMID: 2000 Jan;110(1):23-9. PMID: 10646710. X-2, X-3, X-4 10706300. X-1 1168. Friedman O, Chidekel A, Lawless ST, et al. Postoperative 1157. Oguz F, Citak A, Unuvar E, et al. Airway foreign bodies bilevel positive airway pressure ventilation after tonsillectomy in childhood. Int J Pediatr Otorhinolaryngol. 2000 Jan and adenoidectomy in children--a preliminary report. Int J 30;52(1):11-6. PMID: 10699234. X-2, X-3, X-4 Pediatr Otorhinolaryngol. 1999 Dec 15;51(3):177-80. PMID: 10628544. X-2, X-3, X-4 1158. Jackson AW, Dishman RK. Perceived submaximal force production in young adult males and females. Med Sci Sports 1169. Brooks D, Solway S, Graham I, et al. A survey of Exerc. 2000 Feb;32(2):448-51. PMID: 10694130. X-2, X-3, X- suctioning practices among physical therapists, respiratory 4, X-5 therapists and nurses. Can Respir J. 1999 Nov-Dec;6(6):513-20. PMID: 10623788. X-1 1159. D'A Honey RJ, Luymes J, Weir MJ, et al. Mechanical percussion inversion can result in relocation of lower pole stone 1170. Bhalla KS, Wilczynski SW, Abushamaa AM, et al. fragments after shock wave lithotripsy. Urology. 2000 Pulmonary toxicity of induction chemotherapy prior to standard Feb;55(2):204-6. PMID: 10688079. X-2, X-3, X-4 or high-dose chemotherapy with autologous hematopoietic support. Am J Respir Crit Care Med. 2000 Jan;161(1):17-25. 1160. Savci S, Ince DI, Arikan H. A comparison of autogenic PMID: 10619792. X-2, X-3, X-4, X-5 drainage and the active cycle of breathing techniques in patients with chronic obstructive pulmonary diseases. J Cardiopulm 1171. Engstrom CP, Persson LO, Larsson S, et al. Long-term Rehabil. 2000 Jan-Feb;20(1):37-43. PMID: 10680096. X-5 effects of a pulmonary rehabilitation programme in outpatients with chronic obstructive pulmonary disease: a randomized 1161. Tsunezuka Y, Sato H, Tsubota M, et al. Significance of controlled study. Scand J Rehabil Med. 1999 Dec;31(4):207-13. percutaneous cardiopulmonary bypass support for volume PMID: 10599897. X-2, X-3, X-4, X-5 reduction surgery with severe hypercapnia. Artif Organs. 2000 Jan;24(1):70-3. PMID: 10677160. X-2, X-3, X-4 1172. Moloney E, Kiely JL, McDonnell T, et al. Nocturnal nasal intermittent positive pressure ventilation (NIPPV) therapy for 1162. Matte P, Jacquet L, Van Dyck M, et al. Effects of chronic respiratory failure: long-term effects. Ir Med J. 1999 conventional physiotherapy, continuous positive airway pressure Sep-Oct;92(6):401-3. PMID: 10598422. X-2, X-3 and non-invasive ventilatory support with bilevel positive airway pressure after coronary artery bypass grafting. Acta 1173. Klug B, Bisgaard H. Lung function and short-term Anaesthesiol Scand. 2000 Jan;44(1):75-81. PMID: 10669276. outcome in young asthmatic children. Eur Respir J. 1999 X-2, X-3, X-4 Nov;14(5):1185-9. PMID: 10596711. X-2, X-3, X-4, X-5

1163. Griffiths TL, Burr ML, Campbell IA, et al. Results at 1 1174. Melo J, Homma A, Iturriaga E, et al. Pulmonary year of outpatient multidisciplinary pulmonary rehabilitation: a evaluation and prevalence of non-invasive ventilation in patients randomised controlled trial. Lancet. 2000 Jan 29;355(9201):362- with amyotrophic lateral sclerosis: a multicenter survey and 8. PMID: 10665556. X-2, X-3, X-5 proposal of a pulmonary protocol. J Neurol Sci. 1999 Oct 31;169(1-2):114-7. PMID: 10540018. X-1 1164. Cox CM, Ascione R, Cohen AM, et al. Effect of cardiopulmonary bypass on pulmonary gas exchange: a 1175. Criner GJ, Cordova FC, Furukawa S, et al. Prospective prospective randomized study. Ann Thorac Surg. 2000 randomized trial comparing bilateral lung volume reduction Jan;69(1):140-5. PMID: 10654503. X-2, X-3, X-4 surgery to pulmonary rehabilitation in severe chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1999 Dec;160(6):2018-27. PMID: 10588623. X-2, X-3, X-5

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1176. O'Donnell DE, D'Arsigny C, Raj S, et al. Ventilatory 1187. Kurabayashi H, Machida I, Yoshida Y, et al. Clinical assistance improves exercise endurance in stable congestive analysis of breathing exercise during immersion in 38 degrees C heart failure. Am J Respir Crit Care Med. 1999 water for obstructive and constrictive pulmonary diseases. J Dec;160(6):1804-11. PMID: 10588589. X-2, X-3, X-5 Med. 1999;30(1-2):61-6. PMID: 10515241. X-2, X-3, X-5

1177. Mozes G, Bickels J, Ovadia D, et al. The use of three- 1188. Buck MM, Tilson ER, Andersen JC. Implementation and dimensional computed tomography in evaluating snapping evaluation of an interdisciplinary health professions core scapula syndrome. Orthopedics. 1999 Nov;22(11):1029-33. curriculum. J Allied Health. 1999 Fall;28(3):174-8. PMID: PMID: 10580821. X-2, X-3, X-4, X-5 10507501. X-1

1178. Diaz-Jimenez JP, Martinez-Ballarin JE, Llunell A, et al. 1189. Farre R, Peslin R, Rotger M, et al. Forced oscillation total Efficacy and safety of photodynamic therapy versus Nd-YAG respiratory resistance and spontaneous breathing lung resistance laser resection in NSCLC with airway obstruction. Eur Respir J. in COPD patients. Eur Respir J. 1999 Jul;14(1):172-8. PMID: 1999 Oct;14(4):800-5. PMID: 10573224. X-2, X-3, X-4 10489847. X-2, X-3, X-4, X-5

1179. Lavergne F, Clerici C, Sadoun D, et al. Airway 1190. Wenzel SE, Schwartz LB, Langmack EL, et al. Evidence obstruction in bronchial sarcoidosis: outcome with treatment. that severe asthma can be divided pathologically into two Chest. 1999 Nov;116(5):1194-9. PMID: 10559075. X-2, X-3, X- inflammatory subtypes with distinct physiologic and clinical 4, X-5 characteristics. Am J Respir Crit Care Med. 1999 Sep;160(3):1001-8. PMID: 10471631. X-2, X-3, X-4 1180. Weiner P, Waizman J, Magadle R, et al. The effect of specific inspiratory muscle training on the sensation of dyspnea 1191. Baubin M, Sumann G, Rabl W, et al. Increased frequency and exercise tolerance in patients with congestive heart failure. of thorax injuries with ACD-CPR. Resuscitation. 1999 Clin Cardiol. 1999 Nov;22(11):727-32. PMID: 10554688. X-2, Jun;41(1):33-8. PMID: 10459590. X-2, X-3, X-4 X-3, X-4, X-5 1192. Friedlander P, Aygene E, Kraus DH. Prevention of airway 1181. Pelosi P, Ravagnan I, Giurati G, et al. Positive end- complications in thyroplasty patients requiring endotracheal expiratory pressure improves respiratory function in obese but intubation. Ann Otol Rhinol Laryngol. 1999 Aug;108(8):735-7. not in normal subjects during anesthesia and paralysis. PMID: 10453779. X-2, X-3, X-4, X-5 Anesthesiology. 1999 Nov;91(5):1221-31. PMID: 10551570. X- 2, X-3, X-4, X-5 1193. Blomberg A, Mudway IS, Nordenhall C, et al. Ozone- induced lung function decrements do not correlate with early 1182. Damm M, Eckel HE, Jungehulsing M, et al. Management airway inflammatory or antioxidant responses. Eur Respir J. of acute inflammatory childhood stridor. Otolaryngol Head 1999 Jun;13(6):1418-28. PMID: 10445622. X-2, X-3, X-4, X-5 Neck Surg. 1999 Nov;121(5):633-8. PMID: 10547485. X-2, X- 3, X-4 1194. Fuchs-Climent D, Le Gallais D, Varray A, et al. Quality of life and exercise tolerance in chronic obstructive pulmonary 1183. Cecins NM, Jenkins SC, Pengelley J, et al. The active disease: effects of a short and intensive inpatient rehabilitation cycle of breathing techniques--to tip or not to tip? Respir Med. program. Am J Phys Med Rehabil. 1999 Jul-Aug;78(4):330-5. 1999 Sep;93(9):660-5. PMID: 10542981. X-2, X-5, X-6 PMID: 10418838. X-2, X-3, X-4, X-5, X-6

1184. Clarke RC, Kelly BE, Convery PN, et al. Ventilatory 1195. Jones A, Jones RD, Kwong K, et al. Effect of positioning characteristics in mechanically ventilated patients during manual on recorded lung sound intensities in subjects without hyperventilation for chest physiotherapy. Anaesthesia. 1999 pulmonary dysfunction. Phys Ther. 1999 Jul;79(7):682-90. Oct;54(10):936-40. PMID: 10540056. X-4, X-6 PMID: 10416577. X-1

1185. Boxem T, Muller M, Venmans B, et al. Nd-YAG laser vs 1196. Nakajima Y, Kurihara Y, Niimi H, et al. Efficacy and bronchoscopic electrocautery for palliation of symptomatic complications of the Gianturco-Z tracheobronchial stent for airway obstruction: a cost-effectiveness study. Chest. 1999 malignant airway stenosis. Cardiovasc Intervent Radiol. 1999 Oct;116(4):1108-12. PMID: 10531180. X-2, X-3, X-4 Jul-Aug;22(4):287-92. PMID: 10415217. X-2, X-3, X-4, X-6

1186. Liu EH, Gillbe CE, Watson AC. Anaesthetic management 1197. Kerem E, Bistritzer T, Hanukoglu A, et al. Pulmonary of patients undergoing lung volume reduction surgery for epithelial sodium-channel dysfunction and excess airway liquid treatment of severe emphysema. Anaesth Intensive Care. 1999 in pseudohypoaldosteronism. N Engl J Med. 1999 Jul Oct;27(5):459-63. PMID: 10520384. X-2, X-3, X-4, X-6 15;341(3):156-62. PMID: 10403853. X-1

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1198. Zayas JG, Rubin BK, York EL, et al. Bronchial mucus amputation. Angiology. 1999 Apr;50(4):283-8. PMID: properties in lung cancer: relationship with site of lesion. Can 10225463. X-2, X-3, X-4 Respir J. 1999 May-Jun;6(3):246-52. PMID: 10393286. X-2, X- 3, X-4 1210. Lam S, leRiche JC, Zheng Y, et al. Sex-related differences in bronchial epithelial changes associated with tobacco smoking. 1199. Gabbay E, Williams TJ, Griffiths AP, et al. Maximizing J Natl Cancer Inst. 1999 Apr 21;91(8):691-6. PMID: 10218506. the utilization of donor organs offered for lung transplantation. X-2, X-3, X-4 Am J Respir Crit Care Med. 1999 Jul;160(1):265-71. PMID: 10390410. X-2, X-3, X-4 1211. Brooks D, Lacasse Y, Goldstein RS. Pulmonary rehabilitation programs in Canada: national survey. Can Respir 1200. Hensel M, Kox WJ. Increased intrapulmonary oxygen J. 1999 Jan-Feb;6(1):55-63. PMID: 10202221. X-1 consumption in mechanically ventilated patients with pneumonia. Am J Respir Crit Care Med. 1999 Jul;160(1):137- 1212. Janssens JP, Cicotti E, Fitting JW, et al. Non-invasive 43. PMID: 10390391. X-2, X-3 home ventilation in patients over 75 years of age: tolerance, compliance, and impact on quality of life. Respir Med. 1998 1201. Kleopa KA, Sherman M, Neal B, et al. Bipap improves Dec;92(12):1311-20. PMID: 10197223. X-2, X-3, X-4, X-5 survival and rate of pulmonary function decline in patients with ALS. J Neurol Sci. 1999 Mar 15;164(1):82-8. PMID: 10385053. 1213. Agho AO, Mosley BW, Williams AM. A national survey X-2, X-3 of current admission practices in selected allied health educational programs. J Allied Health. 1999 Spring;28(1):8-14. 1202. Raoof S, Chowdhrey N, Feuerman M, et al. Effect of PMID: 10189605. X-1 combined kinetic therapy and percussion therapy on the resolution of atelectasis in critically ill patients. Chest. 1999 1214. Reis Ferreira JM, Couto AR, Jalles-Tavares N, et al. Jun;115(6):1658-66. PMID: 10378565. X-3 Airway flow limitation in patients with vibroacoustic disease. Aviat Space Environ Med. 1999 Mar;70(3 Pt 2):A63-9. PMID: 1203. Farre R, Rotger M, Marchal F, et al. Assessment of 10189158. X-2, X-3, X-4, X-5 bronchial reactivity by forced oscillation admittance avoids the upper airway artefact. Eur Respir J. 1999 Apr;13(4):761-6. 1215. Lee KW, Im JG, Han JK, et al. Tuberculous stenosis of PMID: 10362037. X-2, X-3, X-4 the left main bronchus: results of treatment with balloons and metallic stents. J Vasc Interv Radiol. 1999 Mar;10(3):352-8. 1204. Olsen MF, Lonroth H, Bake B. Effects of breathing PMID: 10102202. X-2, X-3, X-4 exercises on breathing patterns in obese and non-obese subjects. Clin Physiol. 1999 May;19(3):251-7. PMID: 10361616. X-2, X- 1216. Rosingh HJ, Peek SH. Swallowing and speech in infants 3, X-5 following tracheotomy. Acta Otorhinolaryngol Belg. 1999;53(1):59-63. PMID: 10102041. X-2, X-3, X-4, X-5 1205. Belleguic C, Lena H, Briens E, et al. Tracheobronchial stenting in patients with esophageal cancer involving the central 1217. Sanya AO, Adesina AT. Relationship between estimated airways. Endoscopy. 1999 Mar;31(3):232-6. PMID: 10344427. body fat and some respiratory function indices. Cent Afr J Med. X-2, X-3, X-4 1998 Oct;44(10):254-8. PMID: 10101435. X-2, X-3, X-4, X-5

1206. Lucas C, Rodgers H. Variation in the management of 1218. Beer M, Wittenberg G, Sandstede J, et al. Treatment of dysphagia after stroke: does SLT make a difference? Int J Lang inoperable tracheobronchial obstructive lesions with the Palmaz Commun Disord. 1998;33 Suppl:284-9. PMID: 10343707. X-1 stent. Cardiovasc Intervent Radiol. 1999 Mar-Apr;22(2):109-13. PMID: 10094989. X-2, X-3, X-4 1207. Perrigault PF, Pouzeratte YH, Jaber S, et al. Changes in occlusion pressure (P0.1) and breathing pattern during pressure 1219. Doering TJ, Fieguth HG, Steuernagel B, et al. External support ventilation. Thorax. 1999 Feb;54(2):119-23. PMID: stimuli in the form of vibratory massage after heart or lung 10325915. X-2, X-3, X-4 transplantation. Am J Phys Med Rehabil. 1999 Mar- Apr;78(2):108-10. PMID: 10088583. X-2, X-3, X-4, X-6 1208. Faul JL, Leonard CT, Burke CM, et al. Fluticasone propionate induced alterations to lung function and the 1220. Moghissi K, Dixon K, Stringer M, et al. The place of immunopathology of asthma over time. Thorax. 1998 bronchoscopic photodynamic therapy in advanced unresectable Sep;53(9):753-61. PMID: 10319057. X-2, X-3 lung cancer: experience of 100 cases. Eur J Cardiothorac Surg. 1999 Jan;15(1):1-6. PMID: 10077365. X-2, X-3, X-4, X-5 1209. Chomard D, Habault P, Ledemeney M, et al. Prognostic aspects of TcPO2 in iloprost treatment as an alternative to

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1221. Chen HC, Liu CY, Cheng HF, et al. Chest physiotherapy 1232. Connolly CK, Mamun M, Alcock SM, et al. The does not exacerbate gastroesophageal reflux in patients with Darlington and Northallerton Prospective Asthma Study: best chronic bronchitis and bronchiectasis. Changgeng Yi Xue Za function predicts mortality during the first 10 years. Respir Med. Zhi. 1998 Dec;21(4):409-14. PMID: 10074726. X-3, X-4, X-6 1998 Nov;92(11):1274-80. PMID: 9926140. X-2, X-3, X-4, X-5

1222. Hung TC, Lin HC, Lin KJ, et al. 133Xenon ventilation 1233. Das AK, Davanzo LD, Poiani GJ, et al. Variable scan as a functional assessment in bronchiectasis. Changgeng Yi extrathoracic airflow obstruction and chronic laryngotracheitis Xue Za Zhi. 1998 Dec;21(4):403-8. PMID: 10074725. X-2, X-3, in Gulf War veterans. Chest. 1999 Jan;115(1):97-101. PMID: X-4 9925068. X-2, X-3, X-4, X-5

1223. Starr J, Zawacki BE. Voices from the silent world of 1234. Santoli F, Zerah F, Vasile N, et al. Pulmonary function in doctor and patient. Camb Q Healthc Ethics. 1999 sickle cell disease with or without acute chest syndrome. Eur Spring;8(2):129-38. PMID: 10067184. X-1, X-2, X-3, X-4, X-5, Respir J. 1998 Nov;12(5):1124-9. PMID: 9864008. X-2, X-3, X- X-6 4, X-5

1224. Zalacain R, Sobradillo V, Amilibia J, et al. Predisposing 1235. Kurabayashi H, Machida I, Kubota K. Improvement in factors to bacterial colonization in chronic obstructive ejection fraction by hydrotherapy as rehabilitation in patients pulmonary disease. Eur Respir J. 1999 Feb;13(2):343-8. PMID: with chronic pulmonary emphysema. Physiother Res Int. 10065679. X-2, X-3, X-4 1998;3(4):284-91. PMID: 9859136. X-2, X-3, X-4, X-5

1225. Bohadana AB, Peslin R, Megherbi SE, et al. Dose- 1236. Golijanin D, Katz R, Verstandig A, et al. The supracostal response slope of forced oscillation and forced expiratory percutaneous nephrostomy for treatment of staghorn and parameters in bronchial challenge testing. Eur Respir J. 1999 complex kidney stones. J Endourol. 1998 Oct;12(5):403-5. Feb;13(2):295-300. PMID: 10065671. X-2, X-3, X-4 PMID: 9847059. X-2, X-3, X-4

1226. Fagevik Olsen M, Josefson K, Lonroth H. Chest 1237. Blackwood B. The practice and perception of intensive physiotherapy does not improve the outcome in laparoscopic care staff using the closed suctioning system. J Adv Nurs. 1998 fundoplication and vertical-banded gastroplasty. Surg Endosc. Nov;28(5):1020-9. PMID: 9840873. X-2, X-3, X-4 1999 Mar;13(3):260-3. PMID: 10064759. X-2, X-3 1238. Neve V, Cremer R, Leclerc F, et al. Measurement of 1227. Rajendran AJ, Pandurangi UM, Murali R, et al. Pre- respiratory mechanics in paediatric intensive care: in vitro operative short-term pulmonary rehabilitation for patients of assessment of a pulmonary function device. Intensive Care Med. chronic obstructive pulmonary disease undergoing coronary 1998 Oct;24(10):1083-8. PMID: 9840244. X-2, X-3, X-4, X-5 artery bypass graft surgery. Indian Heart J. 1998 Sep- Oct;50(5):531-4. PMID: 10052279. X-3

1228. Gruhn J, Leggat P, Muller R. Injuries presenting to Army 1239. Montuschi P, Ciabattoni G, Paredi P, et al. 8-Isoprostane physiotherapy in north Queensland, Australia. Mil Med. 1999 as a biomarker of oxidative stress in interstitial lung diseases. Feb;164(2):145-52. PMID: 10050575. X-2, X-3, X-4, X-5 Am J Respir Crit Care Med. 1998 Nov;158(5 Pt 1):1524-7. PMID: 9817703. X-2, X-3, X-4, X-5 1229. ten Hacken NH, Postma DS, Bosma F, et al. Vascular adhesion molecules in nocturnal asthma: a possible role for 1240. Lorino AM, Lofaso F, Duizabo D, et al. Respiratory VCAM-1 in ongoing airway wall inflammation. Clin Exp resistive impedance as an index of airway obstruction during Allergy. 1998 Dec;28(12):1518-25. PMID: 10024223. X-2, X-3, nasal continuous positive airway pressure titration. Am J Respir X-4, X-5 Crit Care Med. 1998 Nov;158(5 Pt 1):1465-70. PMID: 9817694. X-2, X-3, X-4, X-5 1230. Gallon A. Pneumothorax. Nurs Stand. 1998 Nov 25-Dec 1;13(10):35-9. PMID: 9987403. X-1 1241. Tantucci C, Duguet A, Similowski T, et al. Effect of salbutamol on dynamic hyperinflation in chronic obstructive 1231. Blomberg A, Krishna MT, Helleday R, et al. Persistent pulmonary disease patients. Eur Respir J. 1998 Oct;12(4):799- airway inflammation but accommodated antioxidant and lung 804. PMID: 9817148. X-2, X-3, X-4, X-5 function responses after repeated daily exposure to nitrogen dioxide. Am J Respir Crit Care Med. 1999 Feb;159(2):536-43. 1242. Dojat M, Ramaux N, Fontaine D. Scenario recognition for PMID: 9927370. X-2, X-3, X-4, X-5 temporal reasoning in medical domains. Artif Intell Med. 1998 Sep-Oct;14(1-2):139-55. PMID: 9779887. X-1

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1243. Prater ME, Deskin RW. Bronchoscopy and laryngoscopy 1254. Hohlfeld JM, Tiryaki E, Hamm H, et al. Pulmonary findings as indications for tracheotomy in the burned child. Arch surfactant activity is impaired in lung transplant recipients. Am J Otolaryngol Head Neck Surg. 1998 Oct;124(10):1115-7. PMID: Respir Crit Care Med. 1998 Sep;158(3):706-12. PMID: 9776189. X-2, X-3, X-4 9730994. X-2, X-3, X-4

1244. Garry B, Woo P, Perrault DF, Jr., et al. Jet ventilation in 1255. Hellinckx J, De Boeck K, Bande-Knops J, et al. upper airway obstruction: description and model lung testing of Bronchodilator response in 3-6.5 years old healthy and stable a new jetting device. Anesth Analg. 1998 Oct;87(4):915-20. asthmatic children. Eur Respir J. 1998 Aug;12(2):438-43. PMID: 9768794. X-2, X-3, X-4 PMID: 9727798. X-2, X-3, X-4, X-5

1245. Zehr KJ, Dawson PB, Yang SC, et al. Standardized 1256. Remy-Jardin M, Remy J, Artaud D, et al. Volume clinical care pathways for major thoracic cases reduce hospital rendering of the tracheobronchial tree: clinical evaluation of costs. Ann Thorac Surg. 1998 Sep;66(3):914-9. PMID: bronchographic images. Radiology. 1998 Sep;208(3):761-70. 9768951. X-2, X-3, X-4 PMID: 9722857. X-2, X-3, X-4

1246. Kraft M, Striz I, Georges G, et al. Expression of epithelial 1257. Weiner P, Gross D, Meiner Z, et al. Respiratory muscle markers in nocturnal asthma. J Allergy Clin Immunol. 1998 training in patients with moderate to severe myasthenia gravis. Sep;102(3):376-81. PMID: 9768576. X-2, X-3, X-4, X-5 Can J Neurol Sci. 1998 Aug;25(3):236-41. PMID: 9706726. X- 2, X-3, X-4, X-5 1247. Burioka N, Sugimoto Y, Suyama H, et al. Clinical efficacy of the FLUTTER device for airway mucus clearance in 1258. Frey U, Jackson AC, Silverman M. Differences in airway patients with diffuse panbronchiolitis. Respirology. 1998 wall compliance as a possible mechanism for wheezing Sep;3(3):183-6. PMID: 9767617. X-5, X-6 disorders in infants. Eur Respir J. 1998 Jul;12(1):136-42. PMID: 9701428. X-2, X-3, X-4 1248. Laurikka JO, Toivio I, Tarkka MR. Effects of a novel pneumatic vest on postoperative pain and lung function after 1259. Christian DL, Chen LL, Scannell CH, et al. Ozone- coronary artery bypass grafting. Scand Cardiovasc J. induced inflammation is attenuated with multiday exposure. Am 1998;32(3):141-4. PMID: 9764428. X-3, X-4, X-6 J Respir Crit Care Med. 1998 Aug;158(2):532-7. PMID: 9700132. X-2, X-3, X-4, X-5 1249. ten Hacken NH, Timens W, Smith M, et al. Increased peak expiratory flow variation in asthma: severe persistent 1260. Frey U, Silverman M, Kraemer R, et al. High-frequency increase but not nocturnal worsening of airway inflammation. respiratory impedance measured by forced-oscillation technique Eur Respir J. 1998 Sep;12(3):546-50. PMID: 9762777. X-2, X- in infants. Am J Respir Crit Care Med. 1998 Aug;158(2):363- 3, X-4, X-5 70. PMID: 9700108. X-2, X-3, X-4, X-5

1250. Norgaard MA, Andersen CB, Pettersson G. Does 1261. Kristensen MS, Milman N, Jarnvig IL. Pulse oximetry at bronchial artery revascularization influence results concerning fibre-optic bronchoscopy in local anaesthesia: indication for bronchiolitis obliterans syndrome and/or obliterative postbronchoscopy oxygen supplementation? Respir Med. 1998 bronchiolitis after lung transplantation? Eur J Cardiothorac Surg. Mar;92(3):432-7. PMID: 9692101. X-2, X-3, X-4 1998 Sep;14(3):311-8. PMID: 9761443. X-2, X-3, X-4, X-5 1262. Lubrano E, Butterworth M, Hesselden A, et al. An audit 1251. Dolovich M, Rushbrook J, Churchill E, et al. Effect of of anthropometric measurements by medical and physiotherapy continuous lateral rotational therapy on lung mucus transport in staff in patients with ankylosing spondylitis. Clin Rehabil. 1998 mechanically ventilated patients. J Crit Care. 1998 Jun;12(3):216-20. PMID: 9688037. X-2, X-3, X-4, X-5 Sep;13(3):119-25. PMID: 9758026. X-6 1263. Pursnani KG, Bazza Y, Calleja M, et al. Laparoscopic 1252. Ayappa I, Norman RG, Hosselet JJ, et al. Relative cholecystectomy under epidural anesthesia in patients with occurrence of flow limitation and snoring during continuous chronic respiratory disease. Surg Endosc. 1998 Aug;12(8):1082- positive airway pressure titration. Chest. 1998 Sep;114(3):685- 4. PMID: 9685547. X-2, X-3, X-4 90. PMID: 9743151. X-2, X-3, X-4 1264. Nava S. Rehabilitation of patients admitted to a 1253. Mayne ST, Redlich CA, Cullen MR. Dietary vitamin A respiratory intensive care unit. Arch Phys Med Rehabil. 1998 and prevalence of bronchial metaplasia in asbestos-exposed Jul;79(7):849-54. PMID: 9685104. X-3, X-4 workers. Am J Clin Nutr. 1998 Sep;68(3):630-5. PMID: 9734740. X-2, X-3, X-4, X-5 1265. Mlcak R, Desai MH, Robinson E, et al. Lung function following thermal injury in children--an 8-year follow up.

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Burns. 1998 May;24(3):213-6. PMID: 9677023. X-2, X-3, X-4, 1276. Tarnoff M, Moncure M, Jones F, et al. The value of X-5 routine posttracheostomy chest radiography. Chest. 1998 Jun;113(6):1647-9. PMID: 9631806. X-2, X-3, X-4, X-5 1266. . Medical devices; effective date of requirement for premarket approval for three class III preamendments devices-- 1277. Ducharme FM, Davis GM. Respiratory resistance in the FDA. Proposed rule; opportunity to request a change in emergency department: a reproducible and responsive measure classification. Fed Regist. 1998 Aug 18;63(159):44177-81. of asthma severity. Chest. 1998 Jun;113(6):1566-72. PMID: PMID: 10184983. X-1 9631795. X-2, X-3, X-4, X-5

1267. Dasgupta A, Dolmatch BL, Abi-Saleh WJ, et al. Self- 1278. Pinson P, Klastersky J. The value of lung function expandable metallic airway stent insertion employing flexible measurements for the assessment of chemotherapy in lung bronchoscopy: preliminary results. Chest. 1998 Jul;114(1):106- cancer patients. Lung Cancer. 1998 Mar;19(3):179-84. PMID: 9. PMID: 9674455. X-2, X-3, X-4 9631365. X-2, X-3, X-4, X-5

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1270. Borelli M, Benini A, Denkewitz T, et al. Effects of 1281. Spain DA, Bergamini TM, Hoffmann JF, et al. continuous negative extrathoracic pressure versus positive end- Comparison of sequential compression devices and foot pumps expiratory pressure in acute lung injury patients. Crit Care Med. for prophylaxis of deep venous thrombosis in high-risk trauma 1998 Jun;26(6):1025-31. PMID: 9635650. X-3, X-4 patients. Am Surg. 1998 Jun;64(6):522-5; discussion 5-6. PMID: 9619172. X-2, X-3, X-4 1271. Phillips GE, Thomas S, Heather S, et al. Airway response of children with primary ciliary dyskinesia to exercise and 1282. Reper P, Dankaert R, van Hille F, et al. The usefulness of beta2-agonist challenge. Eur Respir J. 1998 Jun;11(6):1389-91. combined high-frequency percussive ventilation during acute PMID: 9657584. X-3, X-5 respiratory failure after smoke inhalation. Burns. 1998 Feb;24(1):34-8. PMID: 9601588. X-1, X-6 1272. . Medical devices; retention in class III and effective date of requirement for premarket approval for three preamendments 1283. Yim AP, Abdullah V, Izzat MB, et al. Video-assisted class III devices--FDA. Proposed rule; opportunity to request a interventional bronchoscopy. The Hong Kong experience. Surg change in classification. Fed Regist. 1998 Jul 30;63(146):40673- Endosc. 1998 May;12(5):444-7. PMID: 9569367. X-2, X-3, X-4 7. PMID: 10181520. X-1 1284. Vandenberg JT, Rudman NT, Burke TF, et al. Large- 1273. Hoshino M, Nakamura Y, Sim JJ, et al. Inhaled diameter suction tubing significantly improves evacuation time corticosteroid reduced lamina reticularis of the basement of simulated vomitus. Am J Emerg Med. 1998 May;16(3):242-4. membrane by modulation of insulin-like growth factor (IGF)-I PMID: 9596423. X-2, X-3, X-4, X-5 expression in bronchial asthma. Clin Exp Allergy. 1998 May;28(5):568-77. PMID: 9645593. X-2, X-3, X-4, X-5 1285. Gillinov AM, Heitmiller RF. Strategies to reduce pulmonary complications after transhiatal esophagectomy. Dis 1274. Bergmann M, Tiroke A, Schafer H, et al. Gene expression Esophagus. 1998 Jan;11(1):43-7. PMID: 9595232. X-3, X-4, X- of profibrotic mediators in bronchiolitis obliterans syndrome 6 after lung transplantation. Scand Cardiovasc J. 1998;32(2):97- 103. PMID: 9636965. X-2, X-3, X-4, X-5 1286. Conacher ID, Paes LL, McMahon CC, et al. Anesthetic management of laser surgery for central airway obstruction: a 1275. Klug B, Bisgaard H. Specific airway resistance, 12-year case series. J Cardiothorac Vasc Anesth. 1998 interrupter resistance, and respiratory impedance in healthy Apr;12(2):153-6. PMID: 9583544. X-1 children aged 2-7 years. Pediatr Pulmonol. 1998 May;25(5):322- 31. PMID: 9635934. X-2, X-3, X-4, X-5 1287. Bardoczky GI, d'Hollander AA, Rocmans P, et al. Respiratory mechanics and gas exchange during one-lung

Appendix-74 ventilation for thoracic surgery: the effects of end-inspiratory 1298. Neumann P, Zinserling J, Haase C, et al. Evaluation of pause in stable COPD patients. J Cardiothorac Vasc Anesth. respiratory inductive plethysmography in controlled ventilation: 1998 Apr;12(2):137-41. PMID: 9583541. X-2, X-3, X-4, X-5 measurement of tidal volume and PEEP-induced changes of end-expiratory lung volume. Chest. 1998 Feb;113(2):443-51. 1288. Sivasothy P, Smith IE, Shneerson JM. Mask intermittent PMID: 9498965. X-3, X-4 positive pressure ventilation in chronic hypercapnic respiratory failure due to chronic obstructive pulmonary disease. Eur Respir 1299. Perrin C, El Far Y, Vandenbos F, et al. Domiciliary nasal J. 1998 Jan;11(1):34-40. PMID: 9543267. X-3, X-4 intermittent positive pressure ventilation in severe COPD: effects on lung function and quality of life. Eur Respir J. 1997 1289. Hutzler Y, Chacham A, Bergman U, et al. Effects of a Dec;10(12):2835-9. PMID: 9493670. X-2, X-3, X-4, X-5 movement and swimming program on vital capacity and water orientation skills of children with cerebral palsy. Dev Med Child 1300. Hayden MJ, Petak F, Hantos Z, et al. Using low- Neurol. 1998 Mar;40(3):176-81. PMID: 9566654. X-2, X-3, X- frequency oscillation to detect bronchodilator responsiveness in 4, X-5 infants. Am J Respir Crit Care Med. 1998 Feb;157(2):574-9. PMID: 9476875. X-2, X-3, X-4, X-5 1290. Weiner P, Zeidan F, Zamir D, et al. Prophylactic inspiratory muscle training in patients undergoing coronary 1301. Lutchen KR, Sullivan A, Arbogast FT, et al. Use of artery bypass graft. World J Surg. 1998 May;22(5):427-31. transfer impedance measurements for clinical assessment of PMID: 9564282. X-3 lung mechanics. Am J Respir Crit Care Med. 1998 Feb;157(2):435-46. PMID: 9476855. X-2, X-3, X-4, X-5 1291. Kurabayashi H, Machida I, Handa H, et al. Comparison of three protocols for breathing exercises during immersion in 38 1302. Slonim SM, Razavi M, Kee S, et al. Transbronchial degrees C water for chronic obstructive pulmonary disease. Am Palmaz stent placement for tracheo-bronchial stenosis. J Vasc J Phys Med Rehabil. 1998 Mar-Apr;77(2):145-8. PMID: Interv Radiol. 1998 Jan-Feb;9(1 Pt 1):153-60. PMID: 9468411. 9558016. X-2, X-3, X-4, X-5 X-2, X-3, X-4, X-5

1292. Perry RJ, Man GC, Jones RL. Effects of positive end- 1303. Rathgeber J, Schorn B, Falk V, et al. The influence of expiratory pressure on oscillated flow rate during high- controlled mandatory ventilation (CMV), intermittent mandatory frequency chest compression. Chest. 1998 Apr;113(4):1028-33. ventilation (IMV) and biphasic intermittent positive airway PMID: 9554642. X-2, X-5, X-6 pressure (BIPAP) on duration of intubation and consumption of analgesics and sedatives. A prospective analysis in 596 patients 1293. Peslin R, Duvivier C. Evaluation of a forced oscillation following adult cardiac surgery. Eur J Anaesthesiol. 1997 method to measure thoracic gas volume. J Appl Physiol. 1998 Nov;14(6):576-82. PMID: 9466092. X-2, X-3, X-4 Mar;84(3):862-7. PMID: 9480944. X-2, X-3, X-4, X-5 1304. Daddi G, Puma F, Avenia N, et al. Resection with curative 1294. Park IW, Choi BW, Hue SH. Prospective study of intent after endoscopic treatment of airway obstruction. Ann corticosteroid as an adjunct in the treatment of endobronchial Thorac Surg. 1998 Jan;65(1):203-7. PMID: 9456118. X-2, X-3, tuberculosis in adults. Respirology. 1997 Dec;2(4):275-81. X-4 PMID: 9525297. X-2, X-3, X-4, X-5 1305. Gray RF, Todd NW, Jacobs IN. Tracheostomy 1295. Rutchik A, Weissman AR, Almenoff PL, et al. Resistive decannulation in children: approaches and techniques. inspiratory muscle training in subjects with chronic cervical Laryngoscope. 1998 Jan;108(1 Pt 1):8-12. PMID: 9432059. X-2, spinal cord injury. Arch Phys Med Rehabil. 1998 X-3, X-4 Mar;79(3):293-7. PMID: 9523781. X-3, X-5 1306. Horowitz MB, Mahler DA. Dyspnea ratings for 1296. Yonan NA, el-Gamel A, Egan J, et al. Single lung prescription of cross-modal exercise in patients with COPD. transplantation for emphysema: predictors for native lung Chest. 1998 Jan;113(1):60-4. PMID: 9440569. X-2, X-3, X-4, hyperinflation. J Heart Lung Transplant. 1998 Feb;17(2):192- X-5 201. PMID: 9513858. X-2, X-3, X-4 1307. Atsuta S, Majima Y. Nasal mucociliary clearance of 1297. Ludwigs U, Philip A. Pulmonary epithelial permeability chronic sinusitis in relation to rheological properties of nasal and gas exchange: a comparison of inverse ratio ventilation and mucus. Ann Otol Rhinol Laryngol. 1998 Jan;107(1):47-51. conventional mechanical ventilation in oleic acid-induced lung PMID: 9439388. X-2, X-3, X-4, X-5 injury in rabbits. Chest. 1998 Feb;113(2):459-66. PMID: 9498967. X-1 1308. Tayama K, Takamori S, Mitsuoka M, et al. Experience of expandable metallic stents for central airway obstruction. Jpn J

Appendix-75

Clin Oncol. 1997 Dec;27(6):401-5. PMID: 9438002. X-2, X-3, 1320. Phagoo SB, Watson RA, Pride NB. Use of nasal peak X-4, X-5 flow to assess nasal patency. Allergy. 1997 Sep;52(9):901-8. PMID: 9298174. X-2, X-3, X-4, X-5 1309. David WS, Bundlie SR, Mahdavi Z. Polysomnographic studies in amyotrophic lateral sclerosis. J Neurol Sci. 1997 1321. Downs CS, Cooper MG. Continuous extrapleural Oct;152 Suppl 1:S29-35. PMID: 9419051. X-3, X-4, X-5 intercostal nerve block for post thoracotomy analgesia in children. Anaesth Intensive Care. 1997 Aug;25(4):390-7. PMID: 1310. Mathieu J, Allard P, Gobeil G, et al. Anesthetic and 9288383. X-2, X-3, X-4 surgical complications in 219 cases of myotonic dystrophy. Neurology. 1997 Dec;49(6):1646-50. PMID: 9409361. X-2, X- 1322. Nishida M, Inaba Y, Tanishita K. Gas dispersion in a 3, X-4, X-5 model pulmonary bifurcation during oscillatory flow. J Biomech Eng. 1997 Aug;119(3):309-16. PMID: 9285344. X-2, X-3, X-4, 1311. Plebani A, Pinzani R, Startari R, et al. Usefulness of chest X-5 physiotherapy with positive expiratory pressure (PEP)-mask in HIV-infected children with recurrent pulmonary infections. Acta 1323. Hoshino M, Nakamura Y, Shin Z, et al. Effects of Paediatr. 1997 Nov;86(11):1195-7. PMID: 9401512. X-5 ketotifen on symptoms and on bronchial mucosa in patients with atopic asthma. Allergy. 1997 Aug;52(8):814-20. PMID: 1312. Ellerman A, Bisgaard H. Longitudinal study of lung 9284980. X-2, X-3, X-4, X-5 function in a cohort of primary ciliary dyskinesia. Eur Respir J. 1997 Oct;10(10):2376-9. PMID: 9387968. X-3, X-5 1324. Kondo T, Uhlig T, Pemberton P, et al. Laser monitoring of chest wall displacement. Eur Respir J. 1997 Aug;10(8):1865- 1313. Takeda S, Nakanishi K, Takano T, et al. External high- 9. PMID: 9272932. X-2, X-3, X-4, X-5 frequency oscillation for hypercapnia after upper abdominal surgery. Nihon Ika Daigaku Zasshi. 1997 Oct;64(5):440-5. 1325. Persons K, Palisson P, Manduca A, et al. An analytical PMID: 9366148. X-2, X-3, X-4, X-5 look at the effects of compression on medical images. J Digit Imaging. 1997 Aug;10(3 Suppl 1):60-6. PMID: 9268841. X-1 1314. Keman S, Willemse B, Tollerud DJ, et al. Blood interleukin-8 production is increased in chemical workers with 1326. Horiuchi K, Jordan D, Cohen D, et al. Insights into the bronchitic symptoms. Am J Ind Med. 1997 Dec;32(6):670-3. increased oxygen demand during chest physiotherapy. Crit Care PMID: 9358925. X-2, X-3, X-4, X-5 Med. 1997 Aug;25(8):1347-51. PMID: 9267948. X-4, X-6

1315. Sidebotham D, Dijkhuizen MR, Schug SA. The safety and 1327. Goldstein RS, Gort EH, Guyatt GH, et al. Economic utilization of patient-controlled analgesia. J Pain Symptom analysis of respiratory rehabilitation. Chest. 1997 Manage. 1997 Oct;14(4):202-9. PMID: 9379067. X-2, X-3, X-4 Aug;112(2):370-9. PMID: 9266871. X-2, X-3, X-4, X-5

1316. Masaoka Y, Homma I. Anxiety and respiratory patterns: 1328. Fligiel SE, Roth MD, Kleerup EC, et al. Tracheobronchial their relationship during mental stress and physical load. Int J histopathology in habitual smokers of cocaine, marijuana, and/or Psychophysiol. 1997 Sep;27(2):153-9. PMID: 9342646. X-2, X- tobacco. Chest. 1997 Aug;112(2):319-26. PMID: 9266864. X-2, 3, X-4, X-5 X-3, X-4, X-5

1317. Ofiara L, Roman T, Schwartzman K, et al. Local 1329. Cahalin LP, Semigran MJ, Dec GW. Inspiratory muscle determinants of response to endobronchial high-dose rate training in patients with chronic heart failure awaiting cardiac brachytherapy in bronchogenic carcinoma. Chest. 1997 transplantation: results of a pilot clinical trial. Phys Ther. 1997 Oct;112(4):946-53. PMID: 9377957. X-2, X-3, X-4 Aug;77(8):830-8. PMID: 9256871. X-2, X-3, X-4, X-5

1318. Nystrom UM, Nystrom NA. Continuous cervical epidural 1330. Nitzkin JL, Zhu N, Marier RL. Reliability of telemedicine anesthesia in reconstructive hand surgery. J Hand Surg Am. examination. Telemed J. 1997 Summer;3(2):141-57. PMID: 1997 Sep;22(5):906-12. PMID: 9330153. X-2, X-3, X-4 10168280. X-2, X-3, X-4, X-5

1319. Emad A, Rezaian GR. The diversity of the effects of 1331. Roth EJ, Lu A, Primack S, et al. Ventilatory function in sulfur mustard gas inhalation on respiratory system 10 years cervical and high thoracic spinal cord injury. Relationship to after a single, heavy exposure: analysis of 197 cases. Chest. level of injury and tone. Am J Phys Med Rehabil. 1997 Jul- 1997 Sep;112(3):734-8. PMID: 9315808. X-2, X-3, X-4, X-5 Aug;76(4):262-7. PMID: 9267184. X-2, X-3

1332. Pasker HG, Peeters M, Genet P, et al. Short-term ventilatory effects in workers exposed to fumes containing zinc

Appendix-76 oxide: comparison of forced oscillation technique with in non-smoking subjects. Occup Environ Med. 1997 spirometry. Eur Respir J. 1997 Jul;10(7):1523-9. PMID: May;54(5):296-300. PMID: 9196449. X-2, X-3, X-4, X-5 9230241. X-2, X-3, X-4, X-5 1344. Ohrstrom M, Holmer C, Larsson M, et al. Indirect 1333. Hauck RW, Lembeck RM, Emslander HP, et al. calorimetry during treadmill walking--a study of two methods. Implantation of Accuflex and Strecker stents in malignant Clin Physiol. 1997 May;17(3):237-45. PMID: 9171964. X-1 bronchial stenoses by flexible bronchoscopy. Chest. 1997 Jul;112(1):134-44. PMID: 9228369. X-2, X-3, X-4 1345. Korst RJ, Humphrey CB. Complete lobar collapse following pulmonary lobectomy. Its incidence, predisposing 1334. Henrich DE, Blythe WR, Weissler MC, et al. factors, and clinical ramifications. Chest. 1997 Tracheotomy and the intensive care unit patient. Laryngoscope. May;111(5):1285-9. PMID: 9149584. X-2, X-3, X-4 1997 Jul;107(7):844-7. PMID: 9217117. X-2, X-3, X-4 1346. Kraft M, Wenzel SE, Bettinger CM, et al. The effect of 1335. Bowman RV. Recent advances in managing non-small- salmeterol on nocturnal symptoms, airway function, and cell lung cancer: 5. Endobronchial palliative therapy. Med J inflammation in asthma. Chest. 1997 May;111(5):1249-54. Aust. 1997 Jun 2;166 Suppl:S17-20. PMID: 9201200. X-1 PMID: 9149578. X-2, X-3

1336. Rozyk KJ, Plusa T, Kuna P, et al. Monocyte chemotactic 1347. Porcellini M, Selvetella L, Del Viscovo L, et al. Aortic and activating factor/monocyte chemoattractant protein in blisters: diagnosis and evolution. Int Surg. 1997 Apr- bronchoalveolar lavage fluid from patients with atopic asthma Jun;82(2):187-9. PMID: 9331850. X-1 and chronic bronchitis. Relationship to lung function tests, bronchial hyper-responsiveness and cytology of bronchoalveolar 1348. Keatings VM, Evans DJ, O'Connor BJ, et al. Cellular lavage fluid. Immunol Lett. 1997 Jun;58(1):47-52. PMID: profiles in asthmatic airways: a comparison of induced sputum, 9436469. X-2, X-3, X-4 bronchial washings, and bronchoalveolar lavage fluid. Thorax. 1997 Apr;52(4):372-4. PMID: 9196522. X-2, X-3, X-4, X-5 1337. Balmes JR, Aris RM, Chen LL, et al. Effects of ozone on normal and potentially sensitive human subjects. Part I: Airway 1349. Michel R, Hauroder B. Isolation of an Acanthamoeba inflammation and responsiveness to ozone in normal and strain with intracellular Burkholderia pickettii infection. asthmatic subjects. Res Rep Health Eff Inst. 1997 Jun(78):1-37; Zentralbl Bakteriol. 1997 Apr;285(4):541-57. PMID: 9144916. discussion 81-99. PMID: 9387195. X-2, X-3, X-4 X-1

1338. Finlay GA, Russell KJ, McMahon KJ, et al. Elevated 1350. Klug B, Bisgaard H. Repeatability of methacholine levels of matrix metalloproteinases in bronchoalveolar lavage challenges in 2- to 4-year-old children with asthma, using a new fluid of emphysematous patients. Thorax. 1997 Jun;52(6):502-6. technique for quantitative delivery of aerosol. Pediatr Pulmonol. PMID: 9227714. X-2, X-3, X-4 1997 Apr;23(4):278-86. PMID: 9141113. X-2, X-3, X-4, X-5, X-6 1339. Hewitson JP, Von Oppell UO. Role of thoracic surgery for childhood tuberculosis. World J Surg. 1997 Jun;21(5):468- 1351. Dolmage TE, Goldstein RS. Proportional assist ventilation 74. PMID: 9204732. X-2, X-3, X-4 and exercise tolerance in subjects with COPD. Chest. 1997 Apr;111(4):948-54. PMID: 9106574. X-2, X-3 1340. Ducharme FM, Davis GM. Measurement of respiratory resistance in the emergency department: feasibility in young 1352. Lehrer P, Generelli P, Hochron S. The effect of facial and children with acute asthma. Chest. 1997 Jun;111(6):1519-25. trapezius muscle tension on respiratory impedance in asthma. PMID: 9187167. X-2, X-3, X-4, X-5 Appl Psychophysiol Biofeedback. 1997 Mar;22(1):43-54. PMID: 9287254. X-1 1341. Ing AJ, Breslin AB. The patient with chronic cough. Med J Aust. 1997 May 5;166(9):491-6. PMID: 9152345. X-1 1353. Oberstein A, von Zitzewitz H, Schweden F, et al. Non invasive evaluation of the inflammatory activity in sarcoidosis 1342. Kurabayashi H, Kubota K, Machida I, et al. Effective with high-resolution computed tomography. Sarcoidosis Vasc physical therapy for chronic obstructive pulmonary disease. Diffuse Lung Dis. 1997 Mar;14(1):65-72. PMID: 9186991. X-2, Pilot study of exercise in hot spring water. Am J Phys Med X-3, X-4, X-5 Rehabil. 1997 May-Jun;76(3):204-7. PMID: 9207705. X-3, X-5 1354. Joris JL, Sottiaux TM, Chiche JD, et al. Effect of bi-level 1343. Akbar-Khanzadeh F, Mlynek JS. Changes in respiratory positive airway pressure (BiPAP) nasal ventilation on the function after one and three hours of exposure to formaldehyde postoperative pulmonary restrictive syndrome in obese patients

Appendix-77 undergoing gastroplasty. Chest. 1997 Mar;111(3):665-70. 1367. Cambach W, Chadwick-Straver RV, Wagenaar RC, et al. PMID: 9118706. X-2, X-3 The effects of a community-based pulmonary rehabilitation programme on exercise tolerance and quality of life: a 1355. Weiner P, Man A, Weiner M, et al. The effect of incentive randomized controlled trial. Eur Respir J. 1997 Jan;10(1):104- spirometry and inspiratory muscle training on pulmonary 13. PMID: 9032501. X-2, X-3, X-4, X-5 function after lung resection. J Thorac Cardiovasc Surg. 1997 Mar;113(3):552-7. PMID: 9081102. X-3, X-4 1368. Timonen KL, Randell JT, Salonen RO, et al. Short-term variations in oscillatory and spirometric lung function indices 1356. Walner DL, Holinger LD. Supraglottic stenosis in infants among school children. Eur Respir J. 1997 Jan;10(1):82-7. and children. A preliminary report. Arch Otolaryngol Head PMID: 9032497. X-2, X-3, X-4, X-5 Neck Surg. 1997 Mar;123(3):337-41. PMID: 9076242. X-2, X- 3, X-4 1369. Gust R, Gottschalk A, Schmidt H, et al. Effects of continuous (CPAP) and bi-level positive airway pressure 1357. Davies L, Mister R, Spence DP, et al. Cardiovascular (BiPAP) on extravascular lung water after extubation of the consequences of fibreoptic bronchoscopy. Eur Respir J. 1997 trachea in patients following coronary artery bypass grafting. Mar;10(3):695-8. PMID: 9073008. X-2, X-3, X-4 Intensive Care Med. 1996 Dec;22(12):1345-50. PMID: 8986484. X-2, X-3, X-4, X-5 1358. Noppen M, Meysman M, D'Haese J, et al. Interventional bronchoscopy: 5-year experience at the Academic Hospital of 1370. Koch SM, Fogarty S, Signorino C, et al. Effect of passive the Vrije Universiteit Brussel (AZ-VUB). Acta Clin Belg. range of motion on intracranial pressure in neurosurgical 1997;52(6):371-80. PMID: 9489133. X-2, X-3, X-4 patients. J Crit Care. 1996 Dec;11(4):176-9. PMID: 8977993. X- 2, X-3, X-4 1359. Kips JC. Preoperative pulmonary evaluation. Acta Clin Belg. 1997;52(5):301-5. PMID: 9489124. X-1 1371. Boldt J, Muller M, Uphus D, et al. Cardiorespiratory changes in patients undergoing pulmonary resection using 1360. Takach TJ, Gregoric I, Campbell JD. Extrapleural suction different anesthetic management techniques. J Cardiothorac buttress of primary esophageal repair. Tex Heart Inst J. Vasc Anesth. 1996 Dec;10(7):854-9. PMID: 8969390. X-2, X-3, 1997;24(4):356-8. PMID: 9456491. X-1 X-4

1361. Thumerelle M. Prescription of child respiratory 1372. Tunkel DE, Fisher QA. Pediatric flexible fiberoptic physiotherapy. Pediatr Pulmonol Suppl. 1997;16:230. PMID: bronchoscopy through the laryngeal mask airway. Arch 9443286. X-1, X-2, X-3, X-4, X-5, X-6 Otolaryngol Head Neck Surg. 1996 Dec;122(12):1364-7. PMID: 8956751. X-2, X-3, X-4 1362. van der Schans CP, de Jong W, de Vries G, et al. Respiratory muscle activity and pulmonary function during 1373. Fridrich P, Krafft P, Hochleuthner H, et al. The effects of acutely induced airways obstruction. Physiother Res Int. long-term prone positioning in patients with trauma-induced 1997;2(3):167-77. PMID: 9421821. X-2, X-3, X-4 adult respiratory distress syndrome. Anesth Analg. 1996 Dec;83(6):1206-11. PMID: 8942587. X-2, X-3, X-4 1363. Turner PA, Whitfield TW. A multidimensional scaling analysis of the techniques that physiotherapists use. Physiother 1374. Marchesan IQ, Krakauer LR. The importance of Res Int. 1997;2(4):237-54. PMID: 9408934. X-2, X-3, X-4, X-5 respiratory activity in myofunctional therapy. Int J Orofacial Myology. 1996 Nov;22:23-7. PMID: 9487822. X-1, X-2, X-3, 1364. Robert M, Marotta J, Rakotomalala E, et al. Piezoelectric X-4, X-5, X-6 extracorporeal shock-wave lithotripsy of lower pole nephrolithiasis. Eur Urol. 1997;32(3):301-4. PMID: 9358217. 1375. Little AF, Phelan EM, Boldt DW, et al. Paediatric X-2, X-3, X-4, X-5 tracheobronchomalacia and its assessment by tracheobronchography. Australas Radiol. 1996 Nov;40(4):398- 1365. Hsu HS, Hsu WH, Huang BS, et al. Surgical treatment of 403. PMID: 8996899. X-1 endobronchial tuberculosis. Scand Cardiovasc J. 1997;31(2):79- 82. PMID: 9211594. X-1 1376. Gavaghan DJ, Hahn CE. A tidal breathing model of the forced inspired inert gas sinewave technique. Respir Physiol. 1366. Gross CW, Zachmann GC, Becker DG, et al. Follow-up 1996 Nov;106(2):209-21. PMID: 8971994. X-1 of University of Virginia experience with the modified Lothrop procedure. Am J Rhinol. 1997 Jan-Feb;11(1):49-54. PMID: 1377. Bolliger CT, Heitz M, Hauser R, et al. An Airway 9065347. X-2, X-3, X-4, X-5 Wallstent for the treatment of tracheobronchial malignancies.

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1378. Barbe F, Quera-Salva MA, de Lattre J, et al. Long-term 1389. Blaski CA, Clapp WD, Thorne PS, et al. The role of atopy effects of nasal intermittent positive-pressure ventilation on in grain dust-induced airway disease. Am J Respir Crit Care pulmonary function and sleep architecture in patients with Med. 1996 Aug;154(2 Pt 1):334-40. PMID: 8756803. X-2, X-3, neuromuscular diseases. Chest. 1996 Nov;110(5):1179-83. X-4, X-5 PMID: 8915217. X-2, X-3, X-4, X-5 1390. Perez A, Mulot R, Vardon G, et al. Thoracoabdominal 1379. Kraft M, Djukanovic R, Wilson S, et al. Alveolar tissue pattern of breathing in neuromuscular disorders. Chest. 1996 inflammation in asthma. Am J Respir Crit Care Med. 1996 Aug;110(2):454-61. PMID: 8697851. X-3 Nov;154(5):1505-10. PMID: 8912772. X-2, X-3, X-4, X-5 1391. Alexander E, Weingarten S, Mohsenifar Z. Clinical 1380. Ratnayake B, Langford RM. A survey of emergency strategies to reduce utilization of chest physiotherapy without airway management in the United Kingdom. Anaesthesia. 1996 compromising patient care. Chest. 1996 Aug;110(2):430-2. Oct;51(10):908-11. PMID: 8984861. X-1, X-2, X-3, X-4, X-5 PMID: 8697846. X-1, X-2, X-3, X-4, X-5, X-6

1381. Fujimoto K, Kubo K, Miyahara T, et al. Effects of muscle 1392. Pelletier-Fleury N, Lanoe JL, Fleury B, et al. The cost of relaxation therapy using specially designed plates in patients treating COPD patients with long-term oxygen therapy in a with pulmonary emphysema. Intern Med. 1996 Oct;35(10):756- French population. Chest. 1996 Aug;110(2):411-6. PMID: 63. PMID: 8933182. X-2, X-3, X-4, X-5 8697843. X-2, X-3, X-4, X-5

1382. Keman S, Willemse B, Wesseling GJ, et al. A five year 1393. Smedley J, Inskip H, Wield G, et al. Work related follow-up of lung function among chemical workers using flow- respiratory symptoms in radiographers. Occup Environ Med. volume and impedance measurements. Eur Respir J. 1996 1996 Jul;53(7):450-4. PMID: 8704868. X-1 Oct;9(10):2109-15. PMID: 8902475. X-2, X-3, X-4, X-5 1394. Dolmage TE, Eisenberg HA, Davis LL, et al. Chest wall 1383. Smith IE, Laroche CM, Jamieson SA, et al. Kyphosis oscillation at 1 Hz reduces spontaneous ventilation in healthy secondary to tuberculosis osteomyelitis as a cause of ventilatory subjects during sleep. Chest. 1996 Jul;110(1):128-35. PMID: failure. Clinical features, mechanisms, and management. Chest. 8681616. X-2, X-3, X-4, X-5 1996 Oct;110(4):1105-10. PMID: 8874277. X-2, X-3, X-4, X-5 1395. Scannell C, Chen L, Aris RM, et al. Greater ozone- 1384. Lehrer PM, Hochron S, Carr R, et al. Behavioral task- induced inflammatory responses in subjects with asthma. Am J induced bronchodilation in asthma during active and passive Respir Crit Care Med. 1996 Jul;154(1):24-9. PMID: 8680687. tasks: a possible cholinergic link to psychologically induced X-2, X-3, X-4, X-5 airway changes. Psychosom Med. 1996 Sep-Oct;58(5):413-22. PMID: 8902893. X-2, X-3, X-4, X-5 1396. Pelosi P, Solca M, Ravagnan I, et al. Effects of heat and moisture exchangers on minute ventilation, ventilatory drive, 1385. Smeltzer SC, Lavietes MH, Cook SD. Expiratory training and work of breathing during pressure-support ventilation in in multiple sclerosis. Arch Phys Med Rehabil. 1996 acute respiratory failure. Crit Care Med. 1996 Jul;24(7):1184-8. Sep;77(9):909-12. PMID: 8822685. X-3, X-4, X-5 PMID: 8674333. X-3

1386. Mathur PN, Wolf KM, Busk MF, et al. Fiberoptic 1397. Kesavanathan J, Swift DL, Fitzgerald TK, et al. bronchoscopic cryotherapy in the management of Evaluation of acoustic rhinometry and posterior tracheobronchial obstruction. Chest. 1996 Sep;110(3):718-23. rhinomanometry as tools for inhalation challenge studies. J PMID: 8797417. X-1 Toxicol Environ Health. 1996 Jun 28;48(3):295-307. PMID: 8656451. X-2, X-3, X-4, X-5 1387. Newman B, Meza MP, Towbin RB, et al. Left pulmonary artery sling: diagnosis and delineation of associated 1398. Barbe F, Togores B, Rubi M, et al. Noninvasive tracheobronchial anomalies with MR. Pediatr Radiol. 1996 ventilatory support does not facilitate recovery from acute Sep;26(9):661-8. PMID: 8781107. X-2, X-3, X-4 respiratory failure in chronic obstructive pulmonary disease. Eur Respir J. 1996 Jun;9(6):1240-5. PMID: 8804944. X-3, X-4 1388. Lin CC. Comparison between nocturnal nasal positive pressure ventilation combined with oxygen therapy and oxygen 1399. Gay PC, Hubmayr RD, Stroetz RW. Efficacy of nocturnal monotherapy in patients with severe COPD. Am J Respir Crit nasal ventilation in stable, severe chronic obstructive pulmonary

Appendix-79 disease during a 3-month controlled trial. Mayo Clin Proc. 1996 numbers of lymphocytes and neutrophils in BAL fluid. Eur Jun;71(6):533-42. PMID: 8642881. X-2, X-3, X-4, X-5 Respir J. 1996 Mar;9(3):524-30. PMID: 8730014. X-1

1400. Wang CH, Lin HC, Huang TJ, et al. Differential effects of 1410. Balmes JR, Chen LL, Scannell C, et al. Ozone-induced nasal continuous positive airway pressure on reversible or fixed decrements in FEV1 and FVC do not correlate with measures of upper and lower airway obstruction. Eur Respir J. 1996 inflammation. Am J Respir Crit Care Med. 1996 May;9(5):952-9. PMID: 8793457. X-2, X-3, X-5 Mar;153(3):904-9. PMID: 8630571. X-2, X-3, X-4, X-5

1401. Klug B, Bisgaard H. Measurement of lung function in 1411. Richmond I, Booth H, Ward C, et al. Intrasubject awake 2-4-year-old asthmatic children during methacholine variability in airway inflammation in biopsies in mild to challenge and acute asthma: a comparison of the impulse moderate stable asthma. Am J Respir Crit Care Med. 1996 oscillation technique, the interrupter technique, and Mar;153(3):899-903. PMID: 8630570. X-2, X-3, X-4, X-5 transcutaneous measurement of oxygen versus whole-body plethysmography. Pediatr Pulmonol. 1996 May;21(5):290-300. 1412. Remacle M, Lawson G, Minet M, et al. Endoscopic PMID: 8726154. X-2, X-3, X-4, X-5 treatment of tracheal stenosis using the carbon dioxide laser and the Gianturco stent: indications and results. Laryngoscope. 1996 1402. Gonzalez O, Smith RL, Goodman SB. Effect of size, Mar;106(3 Pt 1):306-12. PMID: 8614194. X-2, X-3, X-4, X-5 concentration, surface area, and volume of polymethylmethacrylate particles on human macrophages in 1413. Fernandez L, Norwood S, Roettger R, et al. Bedside vitro. J Biomed Mater Res. 1996 Apr;30(4):463-73. PMID: percutaneous tracheostomy with bronchoscopic guidance in 8847354. X-1 critically ill patients. Arch Surg. 1996 Feb;131(2):129-32. PMID: 8611067. X-2, X-3, X-4, X-5 1403. Hall JC, Tarala RA, Hall JL. A case-control study of postoperative pulmonary complications after laparoscopic and 1414. Mathru M, Esch O, Lang J, et al. Magnetic resonance open cholecystectomy. J Laparoendosc Surg. 1996 Apr;6(2):87- imaging of the upper airway. Effects of propofol anesthesia and 92. PMID: 8735045. X-2, X-3, X-4, X-5, X-6 nasal continuous positive airway pressure in humans. Anesthesiology. 1996 Feb;84(2):273-9. PMID: 8602656. X-2, 1404. Borm PJ, Schins RP, Derhaag TJ, et al. Cross-shift X-3, X-4, X-5 changes in blood inflammatory markers occur in the absence of airway obstruction in workers exposed to grain dust. Chest. 1415. Di Stefano A, Turato G, Maestrelli P, et al. Airflow 1996 Apr;109(4):1078-85. PMID: 8635333. X-1 limitation in chronic bronchitis is associated with T-lymphocyte and macrophage infiltration of the bronchial mucosa. Am J 1405. Vigil AR, Clevenger FW. The effects of positive end- Respir Crit Care Med. 1996 Feb;153(2):629-32. PMID: expiratory pressure of intrapulmonary shunt and ventilatory 8564109. X-2, X-3, X-4, X-5 deadspace in nonhypoxic trauma patients. J Trauma. 1996 Apr;40(4):618-22; discussion 22-3. PMID: 8614043. X-2, X-3, 1416. Hall JC, Tarala RA, Tapper J, et al. Prevention of X-4 respiratory complications after abdominal surgery: a randomised clinical trial. BMJ. 1996 Jan 20;312(7024):148-52; discussion 1406. Cohen D, Horiuchi K, Kemper M, et al. Modulating 52-3. PMID: 8563533. X-3, X-4 effects of propofol on metabolic and cardiopulmonary responses to stressful intensive care unit procedures. Crit Care Med. 1996 1417. Skold CM, Barck C, Johard U, et al. The immotile cilia Apr;24(4):612-7. PMID: 8612412. X-2, X-3, X-4 syndrome: characterization of the inflammatory response in nonsmoking patients with dysfunction of the cilia. Respiration. 1407. Poole GV, Thomae KR. Thoracic outlet syndrome 1996;63(6):325-32. PMID: 8933649. X-2, X-3, X-4, X-5 reconsidered. Am Surg. 1996 Apr;62(4):287-91. PMID: 8600849. X-2, X-3, X-4, X-5 1418. Khargi K, Duurkens VA, Versteegh MI, et al. Lung function and perfusion after bronchial and pulmonary arterial 1408. Wilson GE, Walshaw MJ, Hind CR. Treatment of large sleeve resection. Eur J Cardiothorac Surg. 1996;10(9):717-21. airway obstruction in lung cancer using expandable metal stents PMID: 8905272. X-2, X-3, X-4, X-5 inserted under direct vision via the fibreoptic bronchoscope. Thorax. 1996 Mar;51(3):248-52. PMID: 8779125. X-2, X-3, X- 1419. Elliott MJ, Haw MP, Jacobs JP, et al. Tracheal 4, X-5 reconstruction in children using cadaveric homograft trachea. Eur J Cardiothorac Surg. 1996;10(9):707-12. PMID: 8905270. 1409. Pedersen B, Iversen M, Bundgaard Larsen B, et al. Pig X-1 farmers have signs of bronchial inflammation and increased

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1420. Voyagis GS, Papakalou EP. A comparison of the 1432. Phagoo SB, Wilson NM, Silverman M. Evaluation of the laryngeal mask and tracheal tube for controlled ventilation. Acta interrupter technique for measuring change in airway resistance Anaesthesiol Belg. 1996;47(2):81-4. PMID: 8869675. X-2, X-3, in 5-year-old asthmatic children. Pediatr Pulmonol. 1995 X-4, X-5 Dec;20(6):387-95. PMID: 8649919. X-2, X-3, X-4, X-5

1421. Cogliati AA, Menichetti A, Tritapepe L, et al. Effects of 1433. al-Saady NM, Fernando SS, Petros AJ, et al. External high three techniques of lung management on pulmonary function frequency oscillation in normal subjects and in patients with during cardiopulmonary bypass. Acta Anaesthesiol Belg. acute respiratory failure. Anaesthesia. 1995 Dec;50(12):1031-5. 1996;47(2):73-80. PMID: 8869674. X-2, X-3, X-4, X-5 PMID: 8546281. X-2, X-3, X-4, X-6

1422. Balkan ME, Ozdulger A, Tastepe I, et al. Clinical 1434. Brooks D, Thomas J. Interrater reliability of auscultation experience with minitracheotomy. Scand J Thorac Cardiovasc of breath sounds among physical therapists. Phys Ther. 1995 Surg. 1996;30(2):93-6. PMID: 8857682. X-1 Dec;75(12):1082-8. PMID: 7501711. X-2, X-3, X-4, X-5

1423. Harvey LA, Ellis ER. The effect of continuous positive 1435. Servera E, Perez M, Marin J, et al. Noninvasive nasal airway pressures on lung volumes in tetraplegic patients. mask ventilation beyond the ICU for an exacerbation of chronic Paraplegia. 1996 Jan;34(1):54-8. PMID: 8848324. X-2, X-3, X- respiratory insufficiency. Chest. 1995 Dec;108(6):1572-6. 4, X-5 PMID: 7497763. X-3, X-4

1424. Pasker HG, Schepers R, Clement J, et al. Total respiratory 1436. Beydon L, Lorino AM, Verra F, et al. Topical upper impedance measured by means of the forced oscillation airway anaesthesia with lidocaine increases airway resistance by technique in subjects with and without respiratory complaints. impairing glottic function. Intensive Care Med. 1995 Eur Respir J. 1996 Jan;9(1):131-9. PMID: 8834346. X-2, X-3, Nov;21(11):920-6. PMID: 8636524. X-2, X-3, X-4, X-5, X-6 X-4, X-5 1437. Sydow M, Golisch W, Buscher H, et al. Effect of low- 1425. Arnstein FE. A practical evaluation of four human- level PEEP on inspiratory work of breathing in intubated powered portable airway aspirators. Anaesthesia. 1996 patients, both with healthy lungs and with COPD. Intensive Care Jan;51(1):63-8. PMID: 8669569. X-1 Med. 1995 Nov;21(11):887-95. PMID: 8636520. X-2, X-3, X-4, X-5 1426. Yoshimasu T, Miyoshi S, Maebeya S, et al. Evaluation of effect of lung resection on lobar ventilation and perfusion using 1438. Lawhorn CD, Boop FA, Brown RE, Jr., et al. Continuous intrabronchial capnography. Chest. 1996 Jan;109(1):25-30. epidural morphine/butorphanol infusion following selective PMID: 8549192. X-2, X-3, X-4, X-5 dorsal rhizotomy in children. Childs Nerv Syst. 1995 Nov;11(11):621-4. PMID: 8608576. X-2, X-3, X-4, X-5 1427. Clark TJ, McKenna LS, Jewell MJ. Physical therapists' recognition of battered women in clinical settings. Phys Ther. 1439. Carvalhaes-Neto N, Lorino H, Gallinari C, et al. Cognitive 1996 Jan;76(1):12-8; discussion 8-9. PMID: 8545489. X-1 function and assessment of lung function in the elderly. Am J Respir Crit Care Med. 1995 Nov;152(5 Pt 1):1611-5. PMID: 1428. Heijdra YF, Dekhuijzen PN, van Herwaarden CL, et al. 7582303. X-2, X-3, X-4, X-5 Nocturnal saturation improves by target-flow inspiratory muscle training in patients with COPD. Am J Respir Crit Care Med. 1440. Jarjour NN, Busse WW. Cytokines in bronchoalveolar 1996 Jan;153(1):260-5. PMID: 8542126. X-2, X-3, X-4, X-5 lavage fluid of patients with nocturnal asthma. Am J Respir Crit Care Med. 1995 Nov;152(5 Pt 1):1474-7. PMID: 7582279. X-2, 1429. Girgis RE, Reichenspurner H, Robbins RC, et al. The X-3, X-4, X-5 utility of annual surveillance bronchoscopy in heart-lung transplant recipients. Transplantation. 1995 Dec 1441. Ackerman V, Carpi S, Bellini A, et al. Constitutive 27;60(12):1458-61. PMID: 8545874. X-3, X-4, X-5 expression of endothelin in bronchial epithelial cells of patients with symptomatic and asymptomatic asthma and modulation by 1430. Beck R, Odeh M, Oliven A, et al. The acoustic properties histamine and interleukin-1. J Allergy Clin Immunol. 1995 of snores. Eur Respir J. 1995 Dec;8(12):2120-8. PMID: Nov;96(5 Pt 1):618-27. PMID: 7499678. X-2, X-3, X-4, X-5 8666109. X-1 1442. Yazigi A, Madi-Jebara S, Haddad F, et al. Hemodynamic 1431. Bisgaard H, Klug B. Lung function measurement in effects of pressure support ventilation following cardiac surgery. awake young children. Eur Respir J. 1995 Dec;8(12):2067-75. Middle East J Anesthesiol. 1995 Oct;13(3):315-23. PMID: PMID: 8666102. X-2, X-3, X-4, X-5 8849987. X-2, X-3, X-4, X-5

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1443. Tan AK. Incentive spirometry for tracheostomy and 1455. Roth EJ, Nussbaum SB, Berkowitz M, et al. Pulmonary laryngectomy patients. J Otolaryngol. 1995 Oct;24(5):292-4. function testing in spinal cord injury: correlation with vital PMID: 8537988. X-3, X-4, X-6 capacity. Paraplegia. 1995 Aug;33(8):454-7. PMID: 7478739. X-2, X-3, X-4, X-5 1444. Shaver JR, O'Connor JJ, Pollice M, et al. Pulmonary inflammation after segmental ragweed challenge in allergic 1456. Lengacher CA, Mabe PR, Kent K, et al. Design, asthmatic and nonasthmatic subjects. Am J Respir Crit Care implementation, and evaluation of an educational program for a Med. 1995 Oct;152(4 Pt 1):1189-97. PMID: 7551369. X-2, X-3, new practice model. J Nurs Staff Dev. 1995 Jul-Aug;11(4):195- X-4, X-5 200. PMID: 7643228. X-1

1445. Bach JR. Amyotrophic lateral sclerosis: predictors for 1457. Zerah F, Lorino AM, Lorino H, et al. Forced oscillation prolongation of life by noninvasive respiratory aids. Arch Phys technique vs spirometry to assess bronchodilatation in patients Med Rehabil. 1995 Sep;76(9):828-32. PMID: 7668953. X-2, X- with asthma and COPD. Chest. 1995 Jul;108(1):41-7. PMID: 3, X-4, X-5 7606989. X-3

1446. Patton MD, Schaerf R. Thoracotomy, critical pathway, 1458. Booth H, Richmond I, Ward C, et al. Effect of high dose and clinical outcomes. Cancer Pract. 1995 Sep-Oct;3(5):286-94. inhaled fluticasone propionate on airway inflammation in PMID: 7663547. X-1, X-2, X-3, X-4, X-5, X-6 asthma. Am J Respir Crit Care Med. 1995 Jul;152(1):45-52. PMID: 7599861. X-2, X-3, X-4, X-5 1447. Bouros D, Pare P, Panagou P, et al. The varied manifestation of pulmonary artery agenesis in adulthood. Chest. 1459. Takiguchi SA, Myers SA, Yu M, et al. Clinical and 1995 Sep;108(3):670-6. PMID: 7656614. X-2, X-3, X-4, X-5 financial outcomes of lateral rotation low air-loss therapy in patients in the intensive care unit. Heart Lung. 1995 Jul- 1448. Traver GA, Tyler ML, Hudson LD, et al. Continuous Aug;24(4):315-20. PMID: 7591799. X-2, X-3, X-4, X-6 oscillation: outcome in critically ill patients. J Crit Care. 1995 Sep;10(3):97-103. PMID: 7496451. X-3 1460. Brimacombe J, Tucker P, Simons S. The laryngeal mask airway for awake diagnostic bronchoscopy. A retrospective 1449. Ali J, Qi W. Pulmonary function and posture in traumatic study of 200 consecutive patients. Eur J Anaesthesiol. 1995 quadriplegia. J Trauma. 1995 Aug;39(2):334-7. PMID: Jul;12(4):357-61. PMID: 7588664. X-2, X-3, X-4, X-5 7674404. X-2, X-3, X-4, X-5 1461. Viitanen JV, Lehtinen K, Suni J, et al. Fifteen months' 1450. Bailey CR, Jones RM, Kelleher AA. The role of follow-up of intensive inpatient physiotherapy and exercise in continuous positive airway pressure during weaning from ankylosing spondylitis. Clin Rheumatol. 1995 Jul;14(4):413-9. mechanical ventilation in cardiac surgical patients. Anaesthesia. PMID: 7586977. X-2, X-3, X-4, X-5 1995 Aug;50(8):677-81. PMID: 7645695. X-3, X-4, X-5 1462. Watkin DS, Wainwright AM, Thompson MH, et al. 1451. Nozaki-Taguchi N, Isono S, Nishino T, et al. Upper Infection after laparoscopic cholecystectomy: are antibiotics airway obstruction during midazolam sedation: modification by really necessary? Eur J Surg. 1995 Jul;161(7):509-11. PMID: nasal CPAP. Can J Anaesth. 1995 Aug;42(8):685-90. PMID: 7488665. X-2, X-3, X-4, X-5 7586106. X-2, X-3, X-4, X-5 1463. Senekal M, Eales C, Becker PJ. Penetrating stab wounds 1452. Wijkstra PJ, Ten Vergert EM, van Altena R, et al. Long of the chest--when should chest physiotherapy commence? A term benefits of rehabilitation at home on quality of life and comparative study. S Afr J Surg. 1995 Jun;33(2):61-6. PMID: exercise tolerance in patients with chronic obstructive 8545725. X-3, X-4 pulmonary disease. Thorax. 1995 Aug;50(8):824-8. PMID: 7570431. X-2, X-3, X-4, X-5 1464. Blair E, Ballantyne J, Horsman S, et al. A study of a dynamic proximal stability splint in the management of children 1453. Ambrosino N, Vitacca M, Rampulla C. Standards for with cerebral palsy. Dev Med Child Neurol. 1995 rehabilitative strategies in respiratory diseases. Monaldi Arch Jun;37(6):544-54. PMID: 7789663. X-1 Chest Dis. 1995 Aug;50(4):293-318. PMID: 7550210. X-1, X-2, X-3, X-4, X-5, X-6 1465. Harding J, Kemper M, Weissman C. Pressure support ventilation attenuates the cardiopulmonary response to an acute 1454. Pham QT, Bourgkard E, Chau N, et al. Forced oscillation increase in oxygen demand. Chest. 1995 Jun;107(6):1665-72. technique (FOT): a new tool for epidemiology of occupational PMID: 7781365. X-3 lung diseases? Eur Respir J. 1995 Aug;8(8):1307-13. PMID: 7489795. X-2, X-3, X-4, X-5

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1466. Simonds AK, Elliott MW. Outcome of domiciliary nasal Monaldi Arch Chest Dis. 1995 Apr;50(2):150-3. PMID: intermittent positive pressure ventilation in restrictive and 7613548. X-1 obstructive disorders. Thorax. 1995 Jun;50(6):604-9. PMID: 7638799. X-2, X-3, X-4, X-5 1478. Weyland W, Schuhmann M, Rathgeber J, et al. Oxygen cost of breathing for assisted spontaneous breathing modes: 1467. Cuijpers CE, Swaen GM, Wesseling G, et al. Acute investigation into three states of pulmonary function. Intensive respiratory effects of low level summer smog in primary school Care Med. 1995 Mar;21(3):211-7. PMID: 7790606. X-2, X-3, children. Eur Respir J. 1995 Jun;8(6):967-75. PMID: 7589385. X-4, X-5 X-2, X-3, X-4, X-5 1479. Jorres R, Nowak D, Grimminger F, et al. The effect of 1 1468. Richter Larsen K, Ingwersen U, Thode S, et al. Mask ppm nitrogen dioxide on bronchoalveolar lavage cells and physiotherapy in patients after heart surgery: a controlled study. inflammatory mediators in normal and asthmatic subjects. Eur Intensive Care Med. 1995 Jun;21(6):469-74. PMID: 7560489. Respir J. 1995 Mar;8(3):416-24. PMID: 7789487. X-2, X-3, X- X-6 4, X-5

1469. Sonett JR, Keenan RJ, Ferson PF, et al. Endobronchial 1480. Wu RS, Wu KC, Tsai YH, et al. Inhaled fenoterol management of benign, malignant, and lung transplantation pretreatment attenuates airway resistance response to airway stenoses. Ann Thorac Surg. 1995 Jun;59(6):1417-22. endotracheal intubation. Acta Anaesthesiol Sin. 1995 PMID: 7539606. X-2, X-3, X-4, X-5 Mar;33(1):7-14. PMID: 7788204. X-2, X-3, X-4, X-5

1470. Lin M, Yang YF, Chiang HT, et al. Reappraisal of 1481. Silverberg R, Johnson J, Gorga D, et al. A survey of the continuous positive airway pressure therapy in acute cardiogenic prevalence and application of chest physical therapy in U.S. pulmonary edema. Short-term results and long-term follow-up. burn centers. J Burn Care Rehabil. 1995 Mar-Apr;16(2 Pt Chest. 1995 May;107(5):1379-86. PMID: 7750335. X-2, X-3, 1):154-9. PMID: 7775511. X-1 X-4, X-5 1482. Morrell NW, Nijran KS, Biggs T, et al. Regional 1471. Bross MH, Clark JL. Near-drowning. Am Fam Physician. matching of ventilation and perfusion during lobar bronchial 1995 May 1;51(6):1545-51, 55. PMID: 7732954. X-1 occlusion in man. Clin Sci (Lond). 1995 Feb;88(2):179-84. PMID: 7720342. X-2, X-3, X-4, X-5 1472. Gustafson G, Vicini F, Freedman L, et al. High dose rate endobronchial brachytherapy in the management of primary and 1483. Dumont P, Wihlm JM, Hentz JG, et al. Respiratory recurrent bronchogenic malignancies. Cancer. 1995 May complications after surgical treatment of esophageal cancer. A 1;75(9):2345-50. PMID: 7712446. X-2, X-3, X-4, X-5 study of 309 patients according to the type of resection. Eur J Cardiothorac Surg. 1995;9(10):539-43. PMID: 8562096. X-2, 1473. Hidding A, van der Linden S. Factors related to change in X-3 global health after group physical therapy in ankylosing spondylitis. Clin Rheumatol. 1995 May;14(3):347-51. PMID: 1484. Remacle M, Lawson G, Minet M, et al. CO2 laser and 7641514. X-2, X-3, X-4, X-5 Gianturco stent for endoscopic treatment of tracheal stenosis. Acta Otorhinolaryngol Belg. 1995;49(4):351-7. PMID: 1474. van Heerden PV, Jacob W, Cameron PD, et al. 8525833. X-2, X-3, X-4, X-5 Bronchoscopic insufflation of room air for the treatment of lobar atelectasis in mechanically ventilated patients. Anaesth Intensive 1485. Finlay G, Concannon D, McDonnell TJ. Treatment of Care. 1995 Apr;23(2):175-7. PMID: 7793588. X-1 respiratory failure due to kyphoscoliosis with nasal intermittent positive pressure ventilation (NIPPV). Ir J Med Sci. 1995 1475. Elburjo M, Gani EA. Surgical management of pulmonary Jan;164(1):28-30. PMID: 7890530. X-1 hydatid cysts in children. Thorax. 1995 Apr;50(4):396-8. PMID: 7785014. X-2, X-3, X-4, X-5 1486. Cuijpers CE, Swaen GM, Wesseling G, et al. Adverse effects of the indoor environment on respiratory health in 1476. Redington AE, Springall DR, Ghatei MA, et al. primary school children. Environ Res. 1995 Jan;68(1):11-23. Endothelin in bronchoalveolar lavage fluid and its relation to PMID: 7729382. X-2, X-3, X-4, X-5 airflow obstruction in asthma. Am J Respir Crit Care Med. 1995 Apr;151(4):1034-9. PMID: 7697227. X-2, X-3, X-4, X-5 1487. Yiallouros PK, Milner AD. Effective argon-FRC with a rebreathing technique in children with acute asthma. Pediatr 1477. Christensen EF, Jensen RH, Schonemann NK, et al. Flow- Pulmonol. 1995 Jan;19(1):46-51. PMID: 7675556. X-2, X-3, X- dependent properties of positive expiratory pressure devices. 4, X-5

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1488. Agho AO, Williams AM. Actual and desired computer 1499. Ogawa A, Brown CL, Schlueter MA, et al. Lung function, literacy among allied health students. J Allied Health. 1995 surfactant apoprotein content, and level of PEEP in prematurely Spring;24(2):117-26. PMID: 7642439. X-2, X-3, X-4, X-5 delivered rabbits. J Appl Physiol. 1994 Oct;77(4):1840-9. PMID: 7836208. X-1 1489. Vinograd I, Klin B, Efrati Y, et al. Airway obstruction in neonates and children: surgical treatment. J Cardiovasc Surg 1500. Leru P, Bistriceanu G, Ibraim E, et al. Flutter-VRP1 (Torino). 1994 Dec;35(6 Suppl 1):7-12. PMID: 7775560. X-2, Desitin--a new physiotherapeutic device for the treatment of X-3, X-4 chronic obstructive bronchitis. Rom J Intern Med. 1994 Oct- Dec;32(4):315-20. PMID: 7613505. X-5, X-6 1490. Abbott CA, Helliwell PS, Chamberlain MA. Functional assessment in ankylosing spondylitis: evaluation of a new self- 1501. Gaillard D, Jouet JB, Egreteau L, et al. Airway epithelial administered questionnaire and correlation with anthropometric damage and inflammation in children with recurrent bronchitis. variables. Br J Rheumatol. 1994 Nov;33(11):1060-6. PMID: Am J Respir Crit Care Med. 1994 Sep;150(3):810-7. PMID: 7981994. X-1 8087356. X-2, X-3, X-4

1491. Nussbaum E. Usefulness of miniature flexible fiberoptic 1502. Hoheisel G, Chan BK, Chan CH, et al. Endobronchial bronchoscopy in children. Chest. 1994 Nov;106(5):1438-42. tuberculosis: diagnostic features and therapeutic outcome. PMID: 7956397. X-2, X-3, X-4 Respir Med. 1994 Sep;88(8):593-7. PMID: 7991884. X-2, X-3, X-4 1492. Weissman C, Kemper M, Harding J. Response of critically ill patients to increased oxygen demand: hemodynamic 1503. Bohadana AB, Massin N, Teculescu D, et al. Tracheal subsets. Crit Care Med. 1994 Nov;22(11):1809-16. PMID: wheezes during methacholine airway challenge (MAC) in 7956286. X-3, X-4, X-6 workers exposed to occupational hazards. Respir Med. 1994 Sep;88(8):581-7. PMID: 7991882. X-1 1493. Vitacca M, Clini E, Foglio K, et al. Hygroscopic condenser humidifiers in chronically tracheostomized patients 1504. Higgins R, McNeil K, Dennis C, et al. Airway stenoses who breathe spontaneously. Eur Respir J. 1994 Nov;7(11):2026- after lung transplantation: management with expanding metal 32. PMID: 7875277. X-2, X-3, X-4, X-5 stents. J Heart Lung Transplant. 1994 Sep-Oct;13(5):774-8. PMID: 7803417. X-1 1494. Conti G, Rocco M, De Blasi RA, et al. A new device to remove obstruction from endotracheal tubes during mechanical 1505. Chapman CM, Zwillich SH. Olsalazine in ankylosing ventilation in critically ill patients. Intensive Care Med. 1994 spondylitis: a pilot study. J Rheumatol. 1994 Sep;21(9):1699- Nov;20(8):573-6. PMID: 7706570. X-2, X-3, X-4 701. PMID: 7799352. X-2, X-3, X-4, X-5

1495. Wirth-Pattullo V, Hayes KW. Interrater reliability of 1506. Riise GC, Larsson S, Lofdahl CG, et al. Circulating cell craniosacral rate measurements and their relationship with adhesion molecules in bronchial lavage and serum in COPD subjects' and examiners' heart and respiratory rate patients with chronic bronchitis. Eur Respir J. 1994 measurements. Phys Ther. 1994 Oct;74(10):908-16; discussion Sep;7(9):1673-7. PMID: 7527787. X-1 17-20. PMID: 8090842. X-2, X-3, X-4, X-5 1507. Van Noord JA, Smeets J, Clement J, et al. Assessment of 1496. Angueira CE, Kadakia SC. Effects of large-volume reversibility of airflow obstruction. Am J Respir Crit Care Med. paracentesis on pulmonary function in patients with tense 1994 Aug;150(2):551-4. PMID: 8049845. X-2, X-3, X-4 cirrhotic ascites. Hepatology. 1994 Oct;20(4 Pt 1):825-8. PMID: 7927222. X-2, X-3, X-4 1508. Soo Hoo GW, Santiago S, Williams AJ. Nasal mechanical ventilation for hypercapnic respiratory failure in chronic 1497. Weaver LK, Howe S. Arterial oxygen tension of patients obstructive pulmonary disease: determinants of success and with abnormal lungs treated with hyperbaric oxygen is greater failure. Crit Care Med. 1994 Aug;22(8):1253-61. PMID: than predicted. Chest. 1994 Oct;106(4):1134-9. PMID: 7924485. 8045145. X-3 X-2, X-3, X-4 1509. Fisher EW, Lund VJ, Scadding GK. Acoustic rhinometry 1498. Arnold JH, Hanson JH, Toro-Figuero LO, et al. in rhinological practice: discussion paper. J R Soc Med. 1994 Prospective, randomized comparison of high-frequency Jul;87(7):411-3. PMID: 8046730. X-1 oscillatory ventilation and conventional mechanical ventilation in pediatric respiratory failure. Crit Care Med. 1994 1510. Harding J, Kemper M, Weissman C. Midazolam Oct;22(10):1530-9. PMID: 7924362. X-2, X-3, X-4 attenuates the metabolic and cardiopulmonary responses to an

Appendix-84 acute increase in oxygen demand. Chest. 1994 Jul;106(1):194- 1521. Jones DT, Jonas RA, Healy GB. Innominate artery 200. PMID: 8020271. X-3, X-4, X-6 compression of the trachea in infants. Ann Otol Rhinol Laryngol. 1994 May;103(5 Pt 1):347-50. PMID: 8179249. X-1 1511. Olseni L, Midgren B, Hornblad Y, et al. Chest physiotherapy in chronic obstructive pulmonary disease: forced 1522. Rossi A, Santos C, Roca J, et al. Effects of PEEP on expiratory technique combined with either postural drainage or VA/Q mismatching in ventilated patients with chronic airflow positive expiratory pressure breathing. Respir Med. 1994 obstruction. Am J Respir Crit Care Med. 1994 Jul;88(6):435-40. PMID: 7938794. X-2, X-5, X-6 May;149(5):1077-84. PMID: 8173744. X-2, X-3, X-4

1512. Chalmers RM, Howard RS, Wiles CM, et al. Use of the 1523. Cohen KP, Panescu D, Booske JH, et al. Design of an rocking bed in the treatment of neurogenic respiratory inductive plethysmograph for ventilation measurement. Physiol insufficiency. QJM. 1994 Jul;87(7):423-9. PMID: 7922294. X- Meas. 1994 May;15(2):217-29. PMID: 8081197. X-1 3, X-4, X-5, X-6 1524. Iwatsubo Y, Lorino H, Hubert C, et al. Measurement of 1513. Cuijpers CE, Swaen GM, Wesseling G, et al. Acute respiratory impedance by forced oscillation: comparison of the respiratory effects of summer smog in primary school children. standard and head generator methods. Eur Respir J. 1994 Toxicol Lett. 1994 Jun;72(1-3):227-35. PMID: 8202936. X-2, May;7(5):901-6. PMID: 8050547. X-2, X-3, X-4, X-5 X-3, X-4, X-5 1525. van den Elshout FJ, van Herwaarden CL, Folgering HT. 1514. Hasani A, Pavia D, Agnew JE, et al. Regional lung Oscillatory respiratory impedance and lung tissue compliance. clearance during cough and forced expiration technique (FET): Respir Med. 1994 May;88(5):343-7. PMID: 8036302. X-1 effects of flow and viscoelasticity. Thorax. 1994 Jun;49(6):557- 61. PMID: 8016793. X-5 1526. Barker RN, Thomas DP. A practical intervention to address ear and lung disease in Aboriginal primary school 1515. Brunet F, Mira JP, Belghith M, et al. Extracorporeal children of central Australia. J Paediatr Child Health. 1994 carbon dioxide removal technique improves oxygenation Apr;30(2):155-9. PMID: 8198851. X-5 without causing overinflation. Am J Respir Crit Care Med. 1994 Jun;149(6):1557-62. PMID: 8004313. X-2, X-3, X-4, X-5 1527. Kraft M, Beam WR, Wenzel SE, et al. Blood and bronchoalveolar lavage endothelin-1 levels in nocturnal asthma. 1516. Sabanathan S, Mearns AJ, Richardson J. Self-expanding Am J Respir Crit Care Med. 1994 Apr;149(4 Pt 1):946-52. tracheobronchial stents in the management of major airway PMID: 8143060. X-2, X-3, X-4, X-5 problems. J R Coll Surg Edinb. 1994 Jun;39(3):156-61. PMID: 7932334. X-2, X-3, X-4 1528. Everson RB, Schreinemachers DM, Devlin RB, et al. Host determinants of cellular and biochemical constituents of 1517. Ceugniet F, Cauchefer F, Gallego J. Do voluntary changes bronchoalveolar lavage fluids. Implications for design of in inspiratory-expiratory ratio prevent exercise-induced asthma? epidemiologic studies. Am J Respir Crit Care Med. 1994 Biofeedback Self Regul. 1994 Jun;19(2):181-8. PMID: Apr;149(4 Pt 1):899-904. PMID: 8143053. X-1 7918755. X-2, X-3, X-4, X-5 1529. Dawson KP, Steinberg A, Capaldi N. The lateral 1518. Hidding A, van der Linden S, Gielen X, et al. radiograph of neck in laryngo-tracheo-bronchitis (croup). J Qual Continuation of group physical therapy is necessary in Clin Pract. 1994 Mar;14(1):39-43. PMID: 8199758. X-2, X-3, ankylosing spondylitis: results of a randomized controlled trial. X-4, X-5 Arthritis Care Res. 1994 Jun;7(2):90-6. PMID: 7857999. X-2, X-3, X-4, X-5 1530. Lee CM, Wu JL. Fiberoptic bronchoscopic Nd-YAG laser therapy in obstructive airway diseases. Zhonghua Yi Xue Za Zhi 1519. de Souza AC, Keal R, Hudson NM, et al. Use of (Taipei). 1994 Mar;53(3):135-40. PMID: 8174007. X-2, X-3, X- expandable wire stents for malignant airway obstruction. Ann 4, X-5 Thorac Surg. 1994 Jun;57(6):1573-7; discussion 7-8. PMID: 7516647. X-2, X-3, X-4, X-5 1531. Yamazaki Y, Yamakage M, Ujike Y, et al. Changes in work of breathing during continuous positive airway pressure 1520. Henderson A. Chronic respiratory failure. Practitioner. with increased airway resistance. Chest. 1994 Mar;105(3):860-3. 1994 May;238(1538):345-50. PMID: 8183822. X-1, X-2, X-3, PMID: 8131552. X-1 X-4, X-5, X-6 1532. Stiller K, Montarello J, Wallace M, et al. Efficacy of breathing and coughing exercises in the prevention of

Appendix-85 pulmonary complications after coronary artery surgery. Chest. 1544. Swift GL, Rainer T, Saran R, et al. Use of flutter VRP1 in 1994 Mar;105(3):741-7. PMID: 8131535. X-6 the management of patients with steroid-dependent asthma. Respiration. 1994;61(3):126-9. PMID: 8047714. X-2, X-3, X-5 1533. Pairon JC, Iwatsubo Y, Hubert C, et al. Measurement of bronchial responsiveness by forced oscillation technique in 1545. Cuijpers CE, Wesseling GJ, Swaen GM, et al. Asthma- occupational epidemiology. Eur Respir J. 1994 Mar;7(3):484-9. related symptoms and lung function in primary school children. PMID: 8013606. X-2, X-3, X-4, X-5 J Asthma. 1994;31(4):301-12. PMID: 8040154. X-2, X-3, X-5

1534. Mehta AC, Suh JH. Nd:YAG improves outlook for 1546. Inoue H, Aizawa H, Takata S, et al. Ipratropium bromide endobronchial radiation therapy. Clin Laser Mon. 1994 protects against bronchoconstriction during bronchoscopy. Mar;12(3):39-40. PMID: 10146767. X-2, X-3, X-4, X-6 Lung. 1994;172(5):293-8. PMID: 7934153. X-2, X-3, X-4

1535. Vianello A, Bevilacqua M, Salvador V, et al. Long-term 1547. Callaghan SP, Doremus KA, Wilson DJ, et al. nasal intermittent positive pressure ventilation in advanced Minitracheostomy: an alternative to "blind" endotracheal Duchenne's muscular dystrophy. Chest. 1994 Feb;105(2):445-8. suctioning. Dimens Crit Care Nurs. 1994 Jan-Feb;13(1):38-43. PMID: 8306744. X-3 PMID: 7882864. X-1

1536. Macnaughton PD, Evans TW. The effect of exogenous 1548. Milman N, Faurschou P, Grode G, et al. Pulse oximetry surfactant therapy on lung function following cardiopulmonary during fibreoptic bronchoscopy in local anaesthesia: frequency bypass. Chest. 1994 Feb;105(2):421-5. PMID: 8306739. X-3 of hypoxaemia and effect of oxygen supplementation. Respiration. 1994;61(6):342-7. PMID: 7824815. X-2, X-3, X-4 1537. Nathan SD, Ross DJ, Zakowski P, et al. Utility of inhaled pentamidine prophylaxis in lung transplant recipients. Chest. 1549. Brooks D, Wilson L, Kelsey C. Accuracy and reliability 1994 Feb;105(2):417-20. PMID: 8306738. X-1 of 'specialized' physical therapists in auscultating tape-recorded lung sounds. Physiother Can. 1993 Winter;45(1):21-4. PMID: 1538. Tsang KW, Roberts P, Read RC, et al. The concentrations 10124337. X-2, X-3, X-4, X-5 of clarithromycin and its 14-hydroxy metabolite in sputum of patients with bronchiectasis following single dose oral 1550. Webster AC, Morley-Forster PK, Dain S, et al. administration. J Antimicrob Chemother. 1994 Feb;33(2):289- Anaesthesia for adenotonsillectomy: a comparison between 97. PMID: 8182010. X-1 tracheal intubation and the armoured laryngeal mask airway. Can J Anaesth. 1993 Dec;40(12):1171-7. PMID: 8281594. X-2, 1539. Wijkstra PJ, Van Altena R, Kraan J, et al. Quality of life X-3, X-4 in patients with chronic obstructive pulmonary disease improves after rehabilitation at home. Eur Respir J. 1994 Feb;7(2):269-73. 1551. Berry CB, Butler PJ, Myles PS. Lung management during PMID: 8162979. X-3, X-5 cardiopulmonary bypass: is continuous positive airways pressure beneficial? Br J Anaesth. 1993 Dec;71(6):864-8. PMID: 1540. Giffin F, Greenough A. Effect of positive end expiratory 8280555. X-2, X-3, X-4, X-5 pressure and mean airway pressure on respiratory compliance and gas exchange in children with liver disease. Eur J Pediatr. 1552. Kriebel D, Sama SR, Cocanour B. Reversible pulmonary 1994 Jan;153(1):28-33. PMID: 8313921. X-2, X-3 responses to formaldehyde. A study of clinical anatomy students. Am Rev Respir Dis. 1993 Dec;148(6 Pt 1):1509-15. 1541. Jarjour NN, Calhoun WJ. Enhanced production of oxygen PMID: 8256892. X-2, X-3, X-4, X-5 radicals in asthma. J Lab Clin Med. 1994 Jan;123(1):131-6. PMID: 8288953. X-1 1553. Harding J, Kemper M, Weissman C. Alfentanil attenuates the cardiopulmonary response of critically ill patients to an acute 1542. Putensen C, Lingnau W, Hormann C, et al. Subglottic increase in oxygen demand induced by chest physiotherapy. positive end-expiratory pressure in extubated patients recovering Anesth Analg. 1993 Dec;77(6):1122-9. PMID: 8250301. X-3, from acute lung injury. Crit Care Med. 1994 Jan;22(1):67-73. X-4 PMID: 8124977. X-1 1554. Kato R, Kakizaki T, Hangai N, et al. Bronchoplastic 1543. Girard JP, Terki N. The Flutter VRP1: a new personal procedures for tuberculous bronchial stenosis. J Thorac pocket therapeutic device used as an adjunct to drug therapy in Cardiovasc Surg. 1993 Dec;106(6):1118-21. PMID: 8246548. the management of bronchial asthma. J Investig Allergol Clin X-2, X-3, X-4, X-5 Immunol. 1994 Jan-Feb;4(1):23-7. PMID: 8081537. X-2, X-3, X-5 1555. Nagamoto N, Saito Y, Sato M, et al. Clinicopathological analysis of 19 cases of isolated carcinoma in situ of the

Appendix-86 bronchus. Am J Surg Pathol. 1993 Dec;17(12):1234-43. PMID: 1567. Christiani DC, Kern DG. Asthma risk and occupation as a 8238730. X-2, X-3, X-4, X-5 respiratory therapist. Am Rev Respir Dis. 1993 Sep;148(3):671- 4. PMID: 8368639. X-2, X-3, X-4, X-5 1556. Jaeger RJ, Turba RM, Yarkony GM, et al. Cough in spinal cord injured patients: comparison of three methods to produce 1568. Putensen C, Baum M, Hormann C. Selecting ventilator cough. Arch Phys Med Rehabil. 1993 Dec;74(12):1358-61. settings according to variables derived from the quasi-static PMID: 8018145. X-1, X-2, X-3, X-4, X-5, X-6 pressure/volume relationship in patients with acute lung injury. Anesth Analg. 1993 Sep;77(3):436-47. PMID: 8368542. X-2, X- 1557. Daglio SD, Schwitzer R, Wuthrich J, et al. Treating 3, X-4, X-5 orofacial dyskinesia with functional physiotherapy in the case of frontal open bite. Int J Orofacial Myology. 1993 Nov;19:11-4. 1569. Hidding A, van der Linden S, de Witte L. Therapeutic PMID: 9601227. X-1 effects of individual physical therapy in ankylosing spondylitis related to duration of disease. Clin Rheumatol. 1993 1558. Petrou M, Kaplan D, Goldstraw P. Bronchoscopic Sep;12(3):334-40. PMID: 8258231. X-2, X-3, X-4, X-5 diathermy resection and stent insertion: a cost effective treatment for tracheobronchial obstruction. Thorax. 1993 1570. Govaerts E, Demedts M, Van de Woestijne KP. Total Nov;48(11):1156-9. PMID: 8296261. X-2, X-3, X-4, X-5 respiratory impedance and early emphysema. Eur Respir J. 1993 Sep;6(8):1181-5. PMID: 8224134. X-2, X-3, X-4, X-5 1559. Bach JR. Mechanical insufflation-exsufflation. Comparison of peak expiratory flows with manually assisted and 1571. Hidding A, van der Linden S, Boers M, et al. Is group unassisted coughing techniques. Chest. 1993 Nov;104(5):1553- physical therapy superior to individualized therapy in 62. PMID: 8222823. X-5, X-6 ankylosing spondylitis? A randomized controlled trial. Arthritis Care Res. 1993 Sep;6(3):117-25. PMID: 8130287. X-2, X-3, X- 1560. Carpi S, Marini M, Vittori E, et al. Bronchoconstrictive 4, X-5 responses to inhaled ultrasonically nebulized distilled water and airway inflammation in asthma. Chest. 1993 Nov;104(5):1346- 1572. Soopramanien A. Red Cross spinal injury project in 51. PMID: 8222786. X-2, X-3, X-4, X-5 Bucharest, Romania. Paraplegia. 1993 Aug;31(8):521-6. PMID: 8414637. X-1 1561. Merilainen P, Hanninen H, Tuomaala L. A novel sensor for routine continuous spirometry of intubated patients. J Clin 1573. Saroea HG. Chronic obstructive pulmonary disease. Major Monit. 1993 Nov;9(5):374-80. PMID: 8106891. X-1 objectives of management. Postgrad Med. 1993 Aug;94(2):113- 6, 21-2. PMID: 8341621. X-1, X-2, X-3, X-4, X-5, X-6 1562. Whitman J, Van Beusekom R, Olson S, et al. Preliminary evaluation of high-frequency chest compression for secretion 1574. Gross D, Meiner Z. The effect of ventilatory muscle clearance in mechanically ventilated patients. Respir Care. 1993 training on respiratory function and capacity in ambulatory and Oct;38(10):1081-7. PMID: 10145892. X-4 bed-ridden patients with neuromuscular disease. Monaldi Arch Chest Dis. 1993 Aug;48(4):322-6. PMID: 8257974. X-3, X-4, 1563. Clarkson K, Power CK, O'Connell F, et al. A comparative X-5, X-6 evaluation of propofol and midazolam as sedative agents in fiberoptic bronchoscopy. Chest. 1993 Oct;104(4):1029-31. 1575. Henke KG, Sullivan CE. Effects of high-frequency PMID: 8404160. X-2, X-3, X-4, X-5 oscillating pressures on upper airway muscles in humans. J Appl Physiol. 1993 Aug;75(2):856-62. PMID: 8226491. X-2, X-3, X- 1564. Aris R, Christian D, Tager I, et al. Effects of nitric acid 4 gas alone or in combination with ozone on healthy volunteers. Am Rev Respir Dis. 1993 Oct;148(4 Pt 1):965-73. PMID: 1576. Sanna A, Veriter C, Stanescu D. Upper airway obstruction 8214952. X-2, X-3, X-4, X-5 induced by negative-pressure ventilation in awake healthy subjects. J Appl Physiol. 1993 Aug;75(2):546-52. PMID: 1565. Marsh BR, Colvin DP, Zinreich ES, et al. Clinical 8226452. X-2, X-3, X-4, X-5 experience with an endobronchial implant. Radiology. 1993 Oct;189(1):147-50. PMID: 7690488. X-2, X-3, X-4, X-5 1577. Chadelat K, Baculard A, Grimfeld A, et al. Pulmonary sarcoidosis in children: serial evaluation of bronchoalveolar 1566. Wang DY, Pomfrett CJ, Healy TE. Respiratory sinus lavage cells during corticosteroid treatment. Pediatr Pulmonol. arrhythmia: a new, objective sedation score. Br J Anaesth. 1993 1993 Jul;16(1):41-7. PMID: 8414740. X-2, X-3, X-4 Sep;71(3):354-8. PMID: 8398514. X-2, X-3, X-4, X-5 1578. Gimeno F, van der Weele LT, Koeter GH, et al. Variability of forced oscillation (Siemens Siregnost FD 5)

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1583. Weissman C, Kemper M. Stressing the critically ill 1595. Schiffman PL, Belsh JM. Pulmonary function at diagnosis patient: the cardiopulmonary and metabolic responses to an of amyotrophic lateral sclerosis. Rate of deterioration. Chest. acute increase in oxygen consumption. J Crit Care. 1993 1993 Feb;103(2):508-13. PMID: 8432145. X-2, X-3, X-4, X-5 Jun;8(2):100-8. PMID: 8343862. X-3, X-4, X-6 1596. Bach JR, Smith WH, Michaels J, et al. Airway secretion 1584. Thompson AB, Huerta G, Robbins RA, et al. The clearance by mechanical exsufflation for post-poliomyelitis bronchitis index. A semiquantitative visual scale for the ventilator-assisted individuals. Arch Phys Med Rehabil. 1993 assessment of airways inflammation. Chest. 1993 Feb;74(2):170-7. PMID: 8431102. X-5, X-6 May;103(5):1482-8. PMID: 8486031. X-2, X-3, X-4, X-5 1597. McCarthy FM. Emergency drugs and devices--less is 1585. Zerah F, Harf A, Perlemuter L, et al. Effects of obesity on more. J Calif Dent Assoc. 1993 Feb;21(2):19-25. PMID: respiratory resistance. Chest. 1993 May;103(5):1470-6. PMID: 7693888. X-1 8486029. X-2, X-3, X-4, X-5 1598. Marcant D, Rapin CH. Role of the physiotherapist in 1586. Hall JC, Tapper J, Tarala R. The cost-efficiency of palliative care. J Pain Symptom Manage. 1993 Feb;8(2):68-71. incentive spirometry after abdominal surgery. Aust N Z J Surg. PMID: 7684058. X-1 1993 May;63(5):356-9. PMID: 8481135. X-1 1599. Frey U, Schibler A, Kraemer R. The interrupter 1587. Johansen B, Bjortuft O, Boe J. Static lung volumes in technique--a renaissance of a non-invasive approach for lung healthy subjects assessed by helium dilution during occlusion of function testing in infants and children. Agents Actions Suppl. one mainstem bronchus. Thorax. 1993 Apr;48(4):381-4. PMID: 1993;40:64-72. PMID: 8480556. X-2, X-3, X-4, X-5 8511736. X-2, X-3, X-4, X-5 1600. Jindani A, Aps C, Neville E, et al. Postoperative cardiac 1588. Spinelli P, Meroni E, Cerrai FG. A new technique of surgical care: an alternative approach. Br Heart J. 1993 endoscopic implantation of self-expanding mesh stents for Jan;69(1):59-63; discussion -4. PMID: 8457397. X-1, X-2, X-3, inoperable tracheo-bronchial malignancies. Endosc Surg Allied X-4, X-5, X-6 Technol. 1993 Apr;1(2):82-4. PMID: 8055305. X-1 1601. Linder SH. Functional electrical stimulation to enhance 1589. Bien MY, Zadai CC, Kigin CM, et al. The effect of cough in quadriplegia. Chest. 1993 Jan;103(1):166-9. PMID: selective drainage positions on oxygen saturation in obese 8417872. X-3, X-4, X-6 patients after upper abdominal surgery. Zhonghua Yi Xue Za Zhi (Taipei). 1993 Mar;51(3):183-92. PMID: 8490792. X-3, X- 1602. Peters SG, McDougall JC, Douglas WW, et al. Colchicine 4, X-6 in the treatment of pulmonary fibrosis. Chest. 1993 Jan;103(1):101-4. PMID: 8417861. X-2, X-3, X-4, X-5

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1603. Ingwersen UM, Larsen KR, Bertelsen MT, et al. Three Phys Ther. 1992 Nov;72(11):763-9. PMID: 1409873. X-2, X-3, different mask physiotherapy regimens for prevention of post- X-4, X-5 operative pulmonary complications after heart and pulmonary surgery. Intensive Care Med. 1993;19(5):294-8. PMID: 1615. McCaughan JS, Jr., Hawley PC, Brown DG, et al. Effect 8408940. X-6 of light dose on the photodynamic destruction of endobronchial tumors. Ann Thorac Surg. 1992 Oct;54(4):705-11. PMID: 1604. Albertario F, Mapelli A. Considerations on 200 cases of 1417228. X-2, X-3, X-4, X-5 percutaneous cricothyroidotomy (minitracheotomy). Monaldi Arch Chest Dis. 1993;48(3):272-4. PMID: 8369794. X-2, X-3, 1616. al-Arfaj AL, Shahab K, al-Ghassab G, et al. Drainage X-4, X-5 after cholecystectomy. A prospective randomized clinical trial. Int Surg. 1992 Oct-Dec;77(4):274-6. PMID: 1478809. X-2, X-3, 1605. Westaby S, Pillai R, Parry A, et al. Does modern cardiac X-4, X-5 surgery require conventional intensive care? Eur J Cardiothorac Surg. 1993;7(6):313-8; discussion 8. PMID: 8347357. X-1 1617. Tumwine JK. Lung abscess in children in Harare, Zimbabwe. East Afr Med J. 1992 Oct;69(10):547-9. PMID: 1606. Griffith DE, Garcia JG, Dodson RF, et al. Airflow 1473506. X-2, X-3, X-4, X-5 obstruction in nonsmoking, asbestos- and mixed dust-exposed workers. Lung. 1993;171(4):213-24. PMID: 8341088. X-2, X-3, 1618. Shikora SA, MacDonald GF, Bistrian BR, et al. Could the X-4, X-5 oxygen cost of breathing be used to optimize the application of pressure support ventilation? J Trauma. 1992 Oct;33(4):521-6; 1607. Hammon WE, Connors AF, Jr., McCaffree DR. Cardiac discussion 6-7. PMID: 1433397. X-2, X-3, X-4, X-5 arrhythmias during postural drainage and chest percussion of critically ill patients. Chest. 1992 Dec;102(6):1836-41. PMID: 1619. Ohar JA, Jackson F, Dettenmeier PA, et al. 1280190. X-6 Bronchoalveolar lavage cell count and differential are not reliable indicators of amiodarone-induced pneumonitis. Chest. 1608. Cauberghs M, Van de Woestijne KP. Changes of 1992 Oct;102(4):999-1004. PMID: 1395816. X-2, X-3, X-4, X-5 respiratory input impedance during breathing in humans. J Appl Physiol. 1992 Dec;73(6):2355-62. PMID: 1490943. X-2, X-3, 1620. Jarjour NN, Busse WW, Calhoun WJ. Enhanced X-4, X-5 production of oxygen radicals in nocturnal asthma. Am Rev Respir Dis. 1992 Oct;146(4):905-11. PMID: 1329592. X-2, X-3, 1609. Jubran A, Tobin MJ. The effect of hyperinflation on rib X-4, X-5 cage-abdominal motion. Am Rev Respir Dis. 1992 Dec;146(6):1378-82. PMID: 1456551. X-2, X-3, X-4, X-5 1621. Low RB, Giancola MS, King TE, Jr., et al. Serum and bronchoalveolar lavage of N-terminal type III procollagen 1610. George PJ, Irving JD, Khaghani A, et al. Role of the peptides in idiopathic pulmonary fibrosis. Am Rev Respir Dis. Gianturco expandable metal stent in the management of 1992 Sep;146(3):701-6. PMID: 1519851. X-2, X-3, X-4, X-5 tracheobronchial obstruction. Cardiovasc Intervent Radiol. 1992 Nov-Dec;15(6):375-81. PMID: 1477862. X-1 1622. Lynch DA, Rose CS, Way D, et al. Hypersensitivity pneumonitis: sensitivity of high-resolution CT in a population- 1611. Hachenberg T, Brussel T, Roos N, et al. Gas exchange based study. AJR Am J Roentgenol. 1992 Sep;159(3):469-72. impairment and pulmonary densities after cardiac surgery. Acta PMID: 1503007. X-2, X-3, X-4, X-5 Anaesthesiol Scand. 1992 Nov;36(8):800-5. PMID: 1466218. X- 1 1623. Molfino NA, Slutsky AS, Hoffstein V, et al. Changes in cross-sectional airway areas induced by methacholine, 1612. Vittori E, Marini M, Fasoli A, et al. Increased expression histamine, and LTC4 in asthmatic subjects. Am Rev Respir Dis. of endothelin in bronchial epithelial cells of asthmatic patients 1992 Sep;146(3):577-80. PMID: 1519831. X-2, X-3, X-4, X-5 and effect of corticosteroids. Am Rev Respir Dis. 1992 Nov;146(5 Pt 1):1320-5. PMID: 1443891. X-2, X-3, X-4, X-5 1624. Chalker RB, Celli BR, Habib RH, et al. Respiratory input impedance from 4 to 256 Hz in normals and chronic airflow 1613. Ross J, Dean E, Abboud RT. The effect of postural obstruction: comparisons and correlations with spirometry. Am drainage positioning on ventilation homogeneity in healthy Rev Respir Dis. 1992 Sep;146(3):570-6. PMID: 1519830. X-1 subjects. Phys Ther. 1992 Nov;72(11):794-9. PMID: 1409876. X-2, X-5 1625. Fortenberry JD, Mariscalco MM, Louis PT, et al. Severe laryngotracheobronchitis complicating measles. Am J Dis Child. 1614. Derrickson J, Ciesla N, Simpson N, et al. A comparison of 1992 Sep;146(9):1040-3. PMID: 1514548. X-2, X-3, X-4, X-5 two breathing exercise programs for patients with quadriplegia.

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1626. Pozniak AL, Latif AS, Neill P, et al. Pulmonary Kaposi's 1637. Wagner EM, Bleecker ER, Permutt S, et al. Peripheral sarcoma in Africa. Thorax. 1992 Sep;47(9):730-3. PMID: airways resistance in smokers. Am Rev Respir Dis. 1992 1440469. X-2, X-3, X-4, X-5 Jul;146(1):92-5. PMID: 1626822. X-2, X-3, X-4, X-5

1627. Mitchell DM, McCarty M, Fleming J, et al. 1638. Merkle NM, Schluter M, Foitzik T. Minitracheotomy: a Bronchopulmonary Kaposi's sarcoma in patients with AIDS. new interventional technique for treatment of sputum retention. Thorax. 1992 Sep;47(9):726-9. PMID: 1440468. X-2, X-3, X-4, Surg Endosc. 1992 Jul-Aug;6(4):199-204. PMID: 1519152. X-1 X-5 1639. Colt HG, Meric B, Dumon JF. Double stents for 1628. Hoeper MM, Hamm M, Schafers HJ, et al. Evaluation of carcinoma of the esophagus invading the tracheo-bronchial tree. lung function during pulmonary rejection and infection in heart- Gastrointest Endosc. 1992 Jul-Aug;38(4):485-9. PMID: lung transplant patients. Hannover Lung Transplant Group. 1380932. X-2, X-3, X-4, X-5 Chest. 1992 Sep;102(3):864-70. PMID: 1325340. X-1 1640. Brimacombe J, Newell S, Swainston R, et al. A potential 1629. Leung CM, Lee ST. Morbidity and mortality in new technique for awake fibreoptic bronchoscopy--use of the respiratory burns--a prospective study of 240 cases. Ann Acad laryngeal mask airway. Med J Aust. 1992 Jun 15;156(12):876-7. Med Singapore. 1992 Sep;21(5):619-23. PMID: 1292389. X-1, PMID: 1603015. X-2, X-3, X-4, X-5 X-2, X-3, X-4, X-6 1641. Chetta A, Foresi A, Bertorelli G, et al. Lung function and 1630. Popp W, Rauscher H, Ritschka L, et al. Prediction of bronchial responsiveness after bronchoalveolar lavage and interstitial lung involvement in rheumatoid arthritis. The value bronchial biopsy performed without premedication in stable of clinical data, chest roentgenogram, lung function, and asthmatic subjects. Chest. 1992 Jun;101(6):1563-8. PMID: serologic parameters. Chest. 1992 Aug;102(2):391-4. PMID: 1600774. X-2, X-3, X-4, X-5 1643920. X-2, X-3, X-4, X-5 1642. Soldatov NM. Molecular diversity of L-type Ca2+ 1631. Oudjhane K, Bowen A, Oh KS, et al. Pulmonary edema channel transcripts in human fibroblasts. Proc Natl Acad Sci U S complicating upper airway obstruction in infants and children. A. 1992 May 15;89(10):4628-32. PMID: 1316612. X-1 Can Assoc Radiol J. 1992 Aug;43(4):278-82. PMID: 1638426. X-1 1643. Aitken ML, Vincent JM, Pierson DJ. Effects of pulmonary function of oral high frequency oscillation in normal 1632. Thompson AB, Mueller MB, Heires AJ, et al. Aerosolized and asthmatic subjects. Respir Med. 1992 May;86(3):211-4. beclomethasone in chronic bronchitis. Improved pulmonary PMID: 1620908. X-2, X-3, X-5 function and diminished airway inflammation. Am Rev Respir Dis. 1992 Aug;146(2):389-95. PMID: 1489129. X-2, X-3, X-4, 1644. van Belle AF, Wesseling GJ, Penn OC, et al. X-5 Postoperative pulmonary function abnormalities after coronary artery bypass surgery. Respir Med. 1992 May;86(3):195-9. 1633. Berry RB, Light RW. Effect of hyperoxia on the arousal PMID: 1620905. X-2, X-3, X-5 response to airway occlusion during sleep in normal subjects. Am Rev Respir Dis. 1992 Aug;146(2):330-4. PMID: 1489120. 1645. Verra F, Hmouda H, Rauss A, et al. Bronchoalveolar X-2, X-3, X-4, X-5 lavage in immunocompromised patients. Clinical and functional consequences. Chest. 1992 May;101(5):1215-20. PMID: 1634. Guyatt G, Keller J, Singer J, et al. Controlled trial of 1582274. X-2, X-3, X-4, X-6 respiratory muscle training in chronic airflow limitation. Thorax. 1992 Aug;47(8):598-602. PMID: 1412115. X-2, X-3, X-4, X-5 1646. Inderbitzi R, Flueckiger K, Ris HB. Pain relief and respiratory mechanics during continuous intrapleural 1635. Rebeiz EE, Beamis JF, Jr., Vergos K, et al. bupivacaine administration after thoracotomy. Thorac Tracheobronchial obstruction from esophageal carcinoma: Cardiovasc Surg. 1992 Apr;40(2):87-9. PMID: 1631878. X-2, bronchoscopic treatment with neodymium: yttrium-aluminum- X-3, X-4, X-6 garnet laser. Ann Otol Rhinol Laryngol. 1992 Jul;101(7):556-9. PMID: 1378256. X-2, X-3, X-4, X-5 1647. Mayer-Oakes SA, Hoenig H, Atchison KA, et al. Patient- related predictors of rehabilitation use for community-dwelling 1636. Bailey AG, Valley RD, Azizkhan RG, et al. Anaesthetic older Americans. J Am Geriatr Soc. 1992 Apr;40(4):336-42. management of infants requiring endobronchial argon laser PMID: 1556360. X-2, X-3, X-4, X-5 surgery. Can J Anaesth. 1992 Jul;39(6):590-3. PMID: 1643683. X-2, X-3, X-4, X-5 1648. von Knorring J, Lepantalo M, Lindgren L, et al. Cardiac arrhythmias and myocardial ischemia after thoracotomy for lung

Appendix-90 cancer. Ann Thorac Surg. 1992 Apr;53(4):642-7. PMID: impaired immune function. Scand J Infect Dis. 1992;24(1):29- 1554274. X-2, X-3, X-4, X-5 34. PMID: 1350375. X-2, X-3, X-4, X-5

1649. Moores C, Hudson NE, Davies A. The effect of high- 1660. Naumann CP, Ruetsch YA, Fleckenstein W, et al. pO2- frequency ventilation on non-Newtonian properties of bronchial profiles in human muscle tissue as indicator of therapeutical mucus. Respir Med. 1992 Mar;86(2):125-30. PMID: 1615178. effect in septic shock patients. Adv Exp Med Biol. X-1 1992;317:869-77. PMID: 1288215. X-2, X-3

1650. Conway JH, Fleming JS, Perring S, et al. Humidification 1661. Jackson NC. Pulmonary rehabilitation for mechanically as an adjunct to chest physiotherapy in aiding tracheo-bronchial ventilated patients. Crit Care Nurs Clin North Am. 1991 clearance in patients with bronchiectasis. Respir Med. 1992 Dec;3(4):591-600. PMID: 1777195. X-1 Mar;86(2):109-14. PMID: 1615175. X-5, X-6 1662. Strumpf DA, Millman RP, Carlisle CC, et al. Nocturnal 1651. Gimeno F, van der Weele LT, Koeter GH, et al. Forced positive-pressure ventilation via nasal mask in patients with oscillation technique. Reference values for total respiratory severe chronic obstructive pulmonary disease. Am Rev Respir resistance obtained with the Siemens Siregnost FD5. Ann Dis. 1991 Dec;144(6):1234-9. PMID: 1741532. X-2, X-3, X-4, Allergy. 1992 Feb;68(2):155-8. PMID: 1739190. X-1 X-5

1652. Bone RC, Balk R, Slotman G, et al. Adult respiratory 1663. Demetriades D, Breckon V, Breckon C, et al. Antibiotic distress syndrome. Sequence and importance of development of prophylaxis in penetrating injuries of the chest. Ann R Coll Surg multiple organ failure. The Prostaglandin E1 Study Group. Engl. 1991 Nov;73(6):348-51. PMID: 1759762. X-2, X-3, X-4 Chest. 1992 Feb;101(2):320-6. PMID: 1735248. X-2, X-3, X-4 1664. Coleman RF, Schechter GL. A basic model to study 1653. Gerber L, Lampert M, Wood C, et al. Comparison of pain, acoustic evaluation of airway obstruction. Arch Otolaryngol motion, and edema after modified radical mastectomy vs. local Head Neck Surg. 1991 Oct;117(10):1144-9. PMID: 1910701. X- excision with axillary dissection and radiation. Breast Cancer 1 Res Treat. 1992;21(2):139-45. PMID: 1627817. X-2, X-3, X-4 1665. Pollock ML, Carroll JF, Graves JE, et al. Injuries and 1654. Burke C, Power CK, Norris A, et al. Lung function and adherence to walk/jog and resistance training programs in the immunopathological changes after inhaled corticosteroid elderly. Med Sci Sports Exerc. 1991 Oct;23(10):1194-200. therapy in asthma. Eur Respir J. 1992 Jan;5(1):73-9. PMID: PMID: 1758297. X-2, X-3, X-4, X-5 1577153. X-2, X-3, X-5 1666. Elliott MW, Mulvey DA, Moxham J, et al. Domiciliary 1655. Viitanen JV, Suni J, Kautiainen H, et al. Effect of nocturnal nasal intermittent positive pressure ventilation in physiotherapy on spinal mobility in ankylosing spondylitis. COPD: mechanisms underlying changes in arterial blood gas Scand J Rheumatol. 1992;21(1):38-41. PMID: 1570486. X-2, X- tensions. Eur Respir J. 1991 Oct;4(9):1044-52. PMID: 1756837. 3, X-4, X-5 X-2, X-3, X-5

1656. Crozier TA, Sydow M, Siewert JR, et al. Postoperative 1667. van Noord JA, Cauberghs M, Van de Woestijne KP, et al. pulmonary complication rate and long-term changes in Total respiratory resistance and reactance in ankylosing respiratory function following esophagectomy with spondylitis and kyphoscoliosis. Eur Respir J. 1991 esophagogastrostomy. Acta Anaesthesiol Scand. 1992 Sep;4(8):945-51. PMID: 1783085. X-2, X-3, X-4, X-5 Jan;36(1):10-5. PMID: 1539470. X-2, X-3, X-4 1668. Spurzem JR, Thompson AB, Daughton DM, et al. Chronic 1657. Stewart AG, Howard P. Indications for long-term oxygen inflammation is associated with an increased proportion of therapy. Respiration. 1992;59 Suppl 2:8-13. PMID: 1513974. X- goblet cells recovered by bronchial lavage. Chest. 1991 1 Aug;100(2):389-93. PMID: 1864112. X-2, X-3, X-4, X-5

1658. Bagshaw ON, Anaes FR, Hutchinson A. Continuous 1669. Mancebo J, Amaro P, Lorino H, et al. Effects of albuterol arteriovenous haemofiltration and respiratory function in inhalation on the work of breathing during weaning from multiple organ systems failure. Intensive Care Med. mechanical ventilation. Am Rev Respir Dis. 1991 Jul;144(1):95- 1992;18(6):334-8. PMID: 1469160. X-2, X-3, X-4 100. PMID: 2064145. X-2, X-3, X-4

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2002. King M, Zidulka A, Phillips DM, et al. Tracheal mucus airway lesions. Down with the good lung? Chest. 1993 clearance in high-frequency oscillation: effect of peak flow rate Mar;103(3):787-91. PMID: 8449069. X-2, X-3, X-4 bias. Eur Respir J. 1990 Jan;3(1):6-13. PMID: 2311733. X-1 2014. Bjorkqvist M, Wiberg B, Bodin L, et al. Bottle-blowing in 2003. Velmahos GC, Chan LS, Tatevossian R, et al. High- hospital-treated patients with community-acquired pneumonia. frequency percussive ventilation improves oxygenation in Scand J Infect Dis. 1997;29(1):77-82. PMID: 9112303. X-3, X-4 patients with ARDS. Chest. 1999 Aug;116(2):440-6. PMID: 10453874. X-2, X-3, X-4 2015. Clemmer TP, Green S, Ziegler B, et al. Effectiveness of the kinetic treatment table for preventing and treating pulmonary 2004. Fink MP, Helsmoortel CM, Stein KL, et al. The efficacy complications in severely head-injured patients. Crit Care Med. of an oscillating bed in the prevention of lower respiratory tract 1990 Jun;18(6):614-7. PMID: 2344752. X-3 infection in critically ill victims of blunt trauma. A prospective study. Chest. 1990 Jan;97(1):132-7. PMID: 2295232. X-3 2016. Gattinoni L, Tognoni G, Pesenti A, et al. Effect of prone positioning on the survival of patients with acute respiratory 2005. Kirschenbaum L, Azzi E, Sfeir T, et al. Effect of failure. N Engl J Med. 2001 Aug 23;345(8):568-73. PMID: continuous lateral rotational therapy on the prevalence of 11529210. X-2, X-3, X-4 ventilator-associated pneumonia in patients requiring long-term ventilatory care. Crit Care Med. 2002 Sep;30(9):1983-6. PMID: 2017. Romero S, Martin C, Hernandez L, et al. Effect of body 12352030. X-3 position on gas exchange in patients with unilateral pleural effusion: influence of effusion volume. Respir Med. 1995 2006. Tzeng AC, Bach JR. Prevention of pulmonary morbidity Apr;89(4):297-301. PMID: 7597270. X-2, X-3, X-4 for patients with neuromuscular disease. Chest. 2000 Nov;118(5):1390-6. PMID: 11083691. X-2, X-3, X-4, X-5 2018. Chumillas S, Ponce JL, Delgado F, et al. Prevention of postoperative pulmonary complications through respiratory 2007. Ciesla ND. Chest physical therapy for patients in the rehabilitation: a controlled clinical study. Arch Phys Med intensive care unit. Phys Ther. 1996 Jun;76(6):609-25. PMID: Rehabil. 1998 Jan;79(1):5-9. PMID: 9440408. X-4 8650276. X-1, X-2, X-6 2019. Noll DR, Shores J, Bryman PN, et al. Adjunctive 2008. Moiz JA KK, Belsare DR. A comparison of autogenic osteopathic manipulative treatment in the elderly hospitalized drainage and the active cycle of breathing techniques in patients with pneumonia: a pilot study. J Am Osteopath Assoc. 1999 with acute exacerbation of chronic obstructive pulmonary Mar;99(3):143-6, 51-2. PMID: 10217908. X-3, X-4 disease. Indian Journal of Physiotherapy and Occupational Therapy. 2006;1(2):4-6. X-6 2020. Noll DR, Degenhardt BF, Morley TF, et al. Efficacy of osteopathic manipulation as an adjunctive treatment for 2009. Skaria S AA, Sethi J. Effect of positive expiratory hospitalized patients with pneumonia: a randomized controlled pressure technique over forced expiratory technique on trial. Osteopath Med Prim Care. 2010;4:2. PMID: 20302619. X- bronchial hygiene in patients with moderate chronic bronchitis. 3, X-4 Indian Journal of Physiotherapy and Occupational Therapy. 2008;2(3):35-41. X-5 2021. Nicholas KJ, Dhouieb MO, Marshall TG, et al. An Evaluation of Chest Physiotherapy in the Management of Acute 2010. Badr C, Elkins MR, Ellis ER. The effect of body position Bronchiolitis: Changing clinical practice. Physiotherapy. 1999 on maximal expiratory pressure and flow. Aust J Physiother. 12//;85(12):669-74. X-2 2002;48(2):95-102. PMID: 12047207. X-2, X-5, X-6 2022. Felcar JM, Guitti JC, Marson AC, et al. Preoperative 2011. Stiller K, Montarello J, Wallace M, Daff M, Grant R, physiotherapy in prevention of pulmonary complications in Jenkins S, Hall B, Yates H. Are breathing and coughing pediatric cardiac surgery. Rev Bras Cir Cardiovasc. 2008 Jul- exercises necessary after coronary artery surgery? Physiotherapy Sep;23(3):383-8. PMID: 19082328. X-4 Theory and Practice. 1994;10(3):143-52. X-6

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E. Evidence Tables

Intervention(s)/ Study Description Patient Population Outcomes (definition) and Effect Comparator(s) Author: Intervention: IPV for 3 cycles Description of population: Mean Difference G1a vs. G1b (95% CI), p Paneroni et al., 2011 (low pressure/high frequency, Diagnosis of bronchiectasis based on high pressure/low frequency) CT, sputum volume >20 mL/day for 2 Sputum volume (mL): Country: Italy followed by coughing or CPT days, normal gas exchange -0.68 (-3.80 to 2.43), NS (forced expiration, postural drainage, percussion, Baseline measures comparable Sputum (wet weight, g): Intervention setting: vibration in prone or right or between groups: Yes 3.00 (-8.48 to 14.48), NS Hospital respiratory left lateral decubitus positions) department followed by coughing; each Age, mean years ± SD: Sputum (dry weight, g): intervention given for 30 mins G1a +G1b: 64.4 ±8.9 -0.31 (-0.87 to 0.26), NS on 2 consecutive days Study Design: Underlying condition(s), %: Respiratory rate (breaths/min): RCT--crossover Comparator: IPV vs. CPT Bronchiectasis -1.6 (-3.2 to -0.02), p=.047 G1a+G1b: 100 Groups/n: Heart rate (beats/min): G1a (IPV) + G1b (CPT): 22 Mechanical ventilation, %: -0.4 (-3.6 to 2.9), NS G1a+G1b: 0 Followup: 4 hours post- SpO2 (%): treatment 0.6 (-0.7 to 2.0), NS

% available at follow-up: Adverse Effects, %: G1a + G1b: 100 Dry throat, nausea, fatigue G1a+G1b: 27

Post-treatment discomfort (mean ± SD): G1a: 23 ± 17 G1b: 40 ± 27 G1a vs. G1b: p=.03

Dyspnea improved with G1a at T3 (23 ± 20) % from BL (p=0.004) but not with G1b at T3 (27 ± 26) % from BL (p=0.09). No significant difference between Rx groups (p=0.35)

Appendix-108

Study Description Intervention(s)/ Comparator(s) Patient Population Outcomes (definition) and Effect Author: Intervention: High frequency chest Description of population: Adults (≥ Dyspnea (change in Borg score**), median Mahajan et al., 2011 wall compression (inflatable vest)*, 18 yrs of age) hospitalized with (range): 15 minutes 4x/day for total of 60 physician-diagnosed acute asthma or G1 (n=24): -1.5 (-3.5 to 0) Country: US minutes COPD and with FEV1/FVC < 70% G2 (n=26): 0 (-2 to 0) G1 vs. G2: p=0.048 Intervention setting: Comparator: Placebo vest Baseline measures comparable Inpatient medical service between groups: Yes Pulmonary function (Post-bronchodilator FEV1 Groups/n: predicted), % (range): Study Design: G1: Compression/25 Age, median years (range): G1 (n=22): 0 (-2 to 8) RCT G2: Placebo/27 G1: 46.5 (38.6 to 52.8) G2 (n=23): 2 (-3 to 9) G2: 50.4 (43.9 to 60.7) G1 vs. G2: p=NS Followup: Immediately post- treatment for pulmonary and Underlying condition, n (%): Expectorated sputum (wet volume in mL), sputum outcomes, 30 days post- Acute asthma median (range): treatment for exacerbation G1: 15 (60) G1 (n=25): 10 (8 to 20) G2: 16 (59) G2 (n=27): 11 (6 to 45) % available at 30-day follow-up: G1 vs. G2: p=NS G1: 92 Acute COPD G2: 89 G1: 9 (36) Length of stay-hospital (days), median G2: 10 (37) (range): G1 (n=25): 2 (1 to 3) Acute asthma+COPD G2 (n=27): 2 (1 to 4) G1: 1 (4) G1 vs. G2: p= NS G2: 1 (4) Exacerbation (acute care visit—hospitalization Mechanical ventilation, n: or ED visit), n (%): G1+G2: 0 G1 (n=23): 4 (17) G2 (n=24): 4 (17) G1 vs. G2: p=NS

*Study uses term “high frequency chest wall oscillation”; however, we have used “compression” for consistency. ** ≥1 unit reduction defined as clinically meaningful change

Appendix-109

Study Description Intervention(s)/ Comparator(s) Patient Population Outcomes (definition) and Effect Author: Intervention: Flutter valve for two Description of population: Sputum production (sputum volume in mL Chicayban et al., 2011 15-minute periods during pressure Mechanically ventilated adults (>18 collected in each 15-min period): controlled ventilation yrs) with clinical and radiologic G1a: 5.1 ± .5 mL Country: Brazil diagnosis of pulmonary infection and G1b: 3.3 ± .3 mL Comparator: Identical control hypersecretion (need for suctioning in G1a vs. G1b: p<.001 Intervention setting: intervention minus flutter valve <2 hrs) ICU Peak expiratory flow (liters/min), mean ± SEM: Groups/n: Baseline measures comparable G1a: 45.4 ± 4.9 (baseline vs. followup: p<.05) Study Design: G1a: Flutter phase /10 between groups: Similar respiratory G1b: 44.3 ± 4.1 RCT—crossover G1b: Control phase /10 characteristics, but other characteristics NR Peak expiratory flow, percentage variation Followup: Immediately after (liters/min), mean ± SEM*: treatment Age, mean years (SE): G1a: 16.7 ± 6.1 (G1a vs. G1b: p<.05) G1a+G1b: 48.4 (4.3) G1b: 4.5 ± 4.9 % available at follow-up: G1a+G1b: 100, 50% for blood Underlying condition(s), n (%): PaO2 /FiO2 (mm Hg), mean ± SEM* : gases VAP: 15 (75) G1a: 331.6 ± 33.6 (baseline vs. followup: p<.05) Aspiration pneumonia: 5 (25) G1b: 295.5 ± 32.8 Abdominal sepsis: 4 (20) COPD: 7 (35) PaO2 /FiO2 percentage variation (mm Hg), mean Asthma: 2 (10) ± SEM*: Stroke: 4 (20) G1a: 26.5 ± 6.3 (G1a vs. G1b: p <.05) Upper abdominal surgery: 7 (35) G1b: 5.2 ± 2.9 Septic shock: 4 (20) Burn: 1 (5) PaCO2*, mean ± SEM: Heart block: 1 (5) G1a: 38.0 ± 3.5 G1b: 35.3 ± 2.6 (baseline vs. followup: p<.05) Mechanical ventilation, %: G1a+G1b: 100 PaCO2 percentage variation*, mean ± SEM: G1a: -2.7 ± 2.4 APACHE II, mean (SE): G1b: -7.1 ± 3.5 G1a+G1b: 21.7 (2.3) SpO2 (12th minute of 2nd 15 min control or intervention period), mean ± SEM: G1a: 96.1 ± .8 (G1a vs. G1b: p<.05) G1b: 95.8 ± .5

MAP (mm Hg, 12th minute of 2nd 15 min control or intervention period), mean ± SEM: G1a: 85.4 ± 4.7 (rating at first intervention period vs. second period: p<.05) G1b: 95.2 ± 6.9

Appendix-110

Study Description Intervention(s)/ Comparator(s) Patient Population Outcomes (definition) and Effect HR (bpm, 12th minute of 2nd 15 min control or intervention period), mean ± SEM: G1a: 107.2 ± 4.1 G1b: 95.2 ± 4.0 Note: 6 hour washout period between intervention and control *Based on measures from 10 participants with arterial lines (3 measurements/person)

Appendix-111

Intervention(s)/ Study Description Patient Population Outcomes (definition) and Effect Comparator(s) Author: Intervention: Acapella (10 Description of population: Adults Mean difference, G1a vs. G1b (95% CI) Naraparaju et al., 2010 breaths through device with bronchiectasis and history of inhaling to ¾ maximum sputum expectoration of >30 mL/day Sputum volume (mL): Country: India capacity, followed by breath 0.70 (0.13 to 1.27), p=0.014 hold, active exhalation, and Baseline measures comparable Intervention setting: coughing/huffing after every 5 between groups: NR Hospital physical breaths) therapy department Age, mean years ± SD: Comparator: Inspiratory G1a+G1b: 50.7 ± 6.4 Study Design: muscle trainer (IMT; 10 RCT--crossover breaths through devices at Underlying condition(s), n: maximal inspiratory effort, G1a+G1b followed by breath hold, active Bronchiectasis: 30 exhalation, and Tuberculosis: 17 coughing/huffing after every 5 Repeated infections: 13 breaths) Mechanical ventilation, %: Treatments using either the G1a+G1b: 0 Acapella or the IMT were crossed over 2 consecutive days (days 2 and 3)

Groups/n: G1a (Acapella)+G1b (IMT): 30

Followup: 2 hours post- treatment

% available at follow-up: G1a+G1b: 100

Appendix-112

Intervention(s)/ Study Description Patient Population Outcomes (definition) and Effect Comparator(s) Author: Intervention: Manual CPT Description of population: Adults Effect size: Mean Difference (95% CI)** Cross et al., 2010 (percussion, vibration, hospitalized with COPD (British thoracic expansion exercises, Thoracic Society diagnostic criteria) Quality of Life Country: UK FET) + active cycle of exacerbation SGRQ total score: breathing (ACBT) Unadjusted analysis: -0.02 (-0.22 to 0.19) Intervention setting: Baseline measures comparable *Adjusted analysis: 0.03 (-0.14 to 0.19) Secondary hospitals Comparator: Advice on between groups: Yes positioning and ACBT SGRQ symptom score: Study Design: Age, mean years ± SD: Unadjusted analysis: 0.00 (-0.20 to 0.21) RCT Groups/n: G1: 69.08 ± 9.85 Adjusted analysis: 0.04 (-0.15 to 0.23) G1: CPT/261 G2: 69.58 ± 9.51 G2: Control/265 SGRQ activity score: Underlying condition(s), %: Unadjusted analysis: -0.08 (-0.29 to 0.12) Followup: 6 months post- COPD Adjusted analysis: -0.02 (-0.20 to 0.16) treatment G1+G2: 100 SGRQ impact score: % available at follow-up: Mechanical ventilation, %: Unadjusted analysis: 0.00 (-0.20 to 0.2) G1: 71 G1+G2: 0 Adjusted analysis: 0.02 (-0.15 to 0.18) G2: 70 Mean Difference (95% CI) EQ-VAS Unadjusted analysis: 0.96 (-3.37 to 5.29), NS Adjusted analysis: 2.65 (-2.35 to 7.65), NS

EQ-5D Unadjusted analysis: -0.03 (-0.10 to 0.04), NS Adjusted analysis: -0.01 (-0.07 to 0.06), NS

Breathlessness Cough and Sputum Scale: Unadjusted analysis: 0.06 (-0.55 to 0.66), NS Adjusted analysis: 0.01 (-0.54 to 0.56), NS

Exercise tolerance (6 min walk test), meters: Unadjusted analysis: 83.23 (13.09 to 153.37), p=0.02 Adjusted analysis: NR

Length of Stay-hospital (days), mean ± SD: G1 (n=258): 15.95 ± 16.49 G2 (n=264): 16.98 ± 18.04 Adjusted Mean difference : 1.07 (95%CI: 0.91 to 1.24), p=0.42

Appendix-113

Intervention(s)/ Study Description Patient Population Outcomes (definition) and Effect Comparator(s)

Number of hospital admissions in 6-month follow-up period (mean): G1: 3.47 G2: 3.89 p=NR

Adverse Events, n: G1 Increased shortness of breath: 5 Pain: 5 Arrhythmia: 3 Bronchospasm: 1 Thoracic hematoma: 1 *Analyses adjusted for baseline values and hospital site **Numbers per comparison differ. At 6 months: SGRQ, n: G1, G2: 186 each: EQ-5D, n: G1:208, G2:209

Appendix-114

Study Description Intervention(s)/ Comparator(s) Patient Population Outcomes (definition) and Effect Author: Intervention: Description of population: Adults (20- Between group comparisons, mean ± SD Syed et al., 2009 Active cycle of breathing (ACBT) / 60 years) with productive (>30ml Wet sputum weight: CPT (percussion, vibration, cough sputum / day) bronchiectasis 0.96 ± 17.71, t=0.320, p=NS Country: India and breathing techniques) on successive days Baseline measures comparable Sputum volume: Intervention setting: between groups: NR, study notes -1.68 ± 20.50, t= - 0.486, p=NS Hospital Treatment duration for both ACBT varied amount of sputum (30-120 ml), and CPT was 20-30 min every 3 hr type of sputum, and dyspnea grading FVC (1 second), mean ± SD: Study Design: during waking hrs+postural G1a: 1.46 9.14 RCT (crossover) drainage for a maximum of 30 ± minutes with a washout period of12 Age, years (mean ± SD): G1b: -1.80 ± 0.23 hrs between 2 treatments G1a+G1b: 45.8 ± 11.2 G1 vs. G2: p=NS FEV1 (1 second), mean ± SD: Groups/n: Underlying condition, n (%): G1a: -1.49 ± 0.29 G1a: ACBT+CPT/18 G1b: -1.20 ± 0.15 G1b: CPT+ACBT/17 G1a+G1b: G1 vs. G2: p=NS Tuberculosis : 17 (48.6) FEV1/FVC, mean ± SD: Followup: End of therapy Mechanical ventilation, n: G1a: -6.48 ± 9.85 % available at follow-up: G1a+G1b: 0 G1b: -3.84 ± 10 G1+G2: 100 G1 vs. G2: p=NS Significant difference in FEV1/FVC % between pre-post therapy in both groups (p≤0.032)

Appendix-115

Intervention(s)/ Study Description Patient Population Outcomes (definition) and Effect Comparator(s) Author: Intervention: Bronchial Description of population: Adults Mean ± SD: Kodric et al., 2009 drainage via expiration with hospitalized with acute COPD glottis open in lateral posture exacerbation as defined by clinical FEV1/FVC (%): Country: Italy (ELTGOL) for 30-40 mins history, physical exam, and chest x- G1: 52.9 ± 14.6 2x/day for 7 days + medical ray G2: 47.4 ± 14.2 Intervention setting: therapy (steroids, G1 vs. G2: p=NS Hospital bronchodilators, antibiotics) Baseline measures comparable between groups: NR SPO2 (%): Study Design: Comparator: Medical therapy G1: 93.1 ± 2.9 RCT only Age, mean years ± SD: G2: 92.1 ± 3.4 G1: 71.3 ± 8.4 G1 vs. G2: p=NS Groups/n: G2: 69.1 ± 8.3 G1: ELTGOL/30 Sputum (mL/day): G2: Medical therapy only/29 Underlying condition(s), %: G1: 6.8 ± 7.6 COPD G2: 8.2 ± 9.4 Followup: Immediately G1+G2: 100 G1 vs. G2: p=NS following 7 days of treatment; 1 month post-discharge Mechanical ventilation, %: Borg score (10 steps): (QOL), 6 months post- G1+G2: 0 G1: 3.0 ± 1.8 discharge (# exacerbations, G2: 4.3 ± 1.5 admissions) G1 vs. G2: p=0.004

% available at follow-up: Medical Research Council score (5 steps): At 7 days and 1 month: G1: 2.5 ± 1.4 G1: 100 G2: 2.9 ± 1.1 G2: 100 G1 vs. G2: NS

At 6 months: St. George Respiratory Questionnaire (SGRQ): G1: 37 G1: 54.7 ± 17.7 G2: 38 G2: 54.4 ± 19.2 G1 vs. G2: NS

Length of stay (LOS)-hospital (days): G1: 9.5 ± 3.2 G2: 10.0 ± 2.4 G1 vs. G2: NS

One month follow-up QOL (SGRQ): G1: 54.9 ± 17.3 G2: 57.2 ± 19.8 G1 vs. G2: NS

Appendix-116

Intervention(s)/ Study Description Patient Population Outcomes (definition) and Effect Comparator(s) Six month follow-up

*COPD exacerbations: G1 (n=11): 2.8 ± 3.0 G2 (n=11): 3.4 ± 1.7 G1 vs. G2: NS

*Number hospitalizations: G1 (n=11): 1.9 ± 2.5 G2 (n=11): 1.5 ± 1.6 G1 vs. G2: NS

*Group not clearly reported but seems to be as noted

Appendix-117

Study Description Intervention(s)/ Comparator(s) Patient Population Outcomes (definition) and Effect* Author: Intervention: CPT (percussion) Description of population: Children No change in airway resistance (AR) in both DiDario et al., 2009 One ~25 min session every 4 hours with status asthmaticus groups and no difference between groups over over 24 hours time Country: US Baseline measures comparable Comparator: Standard medical between groups: Yes Normal oxygen saturation over time Intervention setting: therapy Phase angle (PA) decreased (p<0.005) in both Study Design: Groups/n: Age, years, n (%): groups over time RCT Standard medical therapy + 4-11 : G1: CPT/20 G1: 15 (75) Peak flow improved (p<0.005) in both groups and G2: No CPT/20 G2: 12 (60) over time

Followup: End of treatment 12-18 : All endpoints improved independent of CPT G1: 5 (25) % available at follow-up: G2: 8 (40) G1: 95 G2: 95 Underlying condition, n (%): Asthma severity: Intermittent: G1: 9 (45) , G2: 7 (35) Moderate-persistent: G1: 11 (55), G2: 13 (65)

Mechanical ventilation: NR

*Note: Data presented graphically only

Appendix-118

Intervention(s)/ Study Description Patient Population Outcomes (definition) and Effect Comparator(s) Author: Intervention: Positioning plus Description of population: Critically Sputum volume (dry weight, mg/24 hr), mean ± Chen et al., 2009 mechanical chest vibration 6 ill adults ages 20-85 years with SD: times/day (once every 4 hrs APACHE II score of 15-40, expected G1: 4.04 ± 3.43 Country: China (Taiwan) for 72 hrs) to need ventilator for >3 days G2: 3.56 ± 3.10 G1 vs. G2: p=NS Intervention setting: ICU Comparator: Routine Baseline measures comparable positioning with position between groups: Yes Generalized Estimating Equation change every 2 hrs Sputum Volume (dry weight, 72 hr post-test Study Design: Age, mean years ± SD: vs. pre-test): RCT Groups/n: G1: 73 ± 15.6 β ± std err: 0.159 ± 1.008, p=NS G1: Vibration/50 G2: 66.8 ± 19.8 G2: Positioning only/45 Underlying condition(s), n (%): Followup: Immediately post- Sepsis intervention G1: 20 (40) G2: 16 (35.6) % available at follow-up: G1: 100 Respiratory failure G2: 100 G1: 19 (38.0) G2: 16 (35.6)

Surgery G1: 11 (22.0) G2: 18 (40.0)

Mechanical ventilation, %: G1+G2: 100

Appendix-119

Intervention(s)/ Study Description Patient Population Outcomes (definition) and Effect Comparator(s) Author: Intervention: 30 minute Description of population: Time to clinical resolution, median days Paludo et al., 2008 session of CPT (postural Hospitalized children (29 days to 12 (interquartile range): drainage, thoracic squeezing, yrs) with a diagnosis of acute G1: 4.0 (2.0 to 7.0) Country: Brazil percussion, vibration, cough pneumonia G2: 4.0 (3.0 to 6.0) stimulation, aspiration of G1 v. G2: p=NS secretions) + standard therapy Baseline measures comparable Intervention setting: for pneumonia until discharge between groups: Yes Length of stay-hospital (days): Tertiary Pediatric hospital G1: 6.0 (4.0 to 9.0) units Comparator: Standard Age, mean months (range): G2: 6.0 (4.0 to 8.0) pneumonia treatment G1: 44.0 (31.6 to 56.4) G1 v. G2: p=NS G2: 32.2 (22.5 to 41.9) Study Design: Groups/n: Time to normal respiratory rate: RCT G1: CPT/51 Underlying condition(s), %: G1: 3.0 (0 to 7.0) G2: Standard care/47 Pneumonia G2: 3.0 (1.0 to 6.0) G1+G2: 100 G1 v. G2: p=NS Followup: Up to hospital discharge Mechanical ventilation, %: Time to normal arterial O2 saturation (≥95%): G1+G2: 0 G1: 1.0 (0 to 2.0) % available at follow-up: G2: 0.5 (0 to 2.0) G1: 92 G1 v. G2: p=NS G2: 89 Time to normal lung auscultation: G1: 4.0 (3.0 to 6.0) G2: 4.0 (2.0 to 6.0) G1 v. G2: p=NS

Duration of coughing: G1: 5.0 (4.0 to 8.0) G2: 4.0 (3.0 to 6.0) G1 v. G2: p=0.04

Duration of parent-reported wheezing: G1: 1.5 (0 to 5.0) G2: 1.0 (0 to 3.5) G1 v. G2: p=NS

Duration of fine crackles: G1: 0 (0 to 2.0) G2: 0 (0 to 2.0) G1 v. G2: p=NS Duration of coarse crackles: G1: 2.0 (0 to 4.0)

Appendix-120

Intervention(s)/ Study Description Patient Population Outcomes (definition) and Effect Comparator(s) G2: 1.0 (0 to 3.0) G1 v. G2: p=NS

Duration of wheezes: G1: 0 (0 to 5.0) G2: 0 (0 to 4.0) G1 v. G2: p=NS

Duration of rhonchi: G1: 2.0 (0 to 4.0) G2: 0.5 (0 to 2.0) G1 v. G2: 0.03

Duration of chest indrawing: G1: 2.0 (0 to 3.0) G2: 2.0 (0 to 3.0) G1 v. G2: p=NS

Appendix-121

Intervention(s)/ Study Description Patient Population Outcomes (definition) and Effect Comparator(s) Author: Intervention: Incentive Description of population: Adults 7-day Followup Haeffener et al., 2008 spirometry (IS) + expiratory (>50 yrs) with Ischemic heart disease Total lung capacity (liters): positive airway pressure undergoing CABG with mammary G1: 4.5 ± 1.1 (baseline vs. 1 week: p<.001) Country: Brazil (EPAP)—IS/EPAP protocol artery graft G2: 4.7 ± 1.1 (baseline vs. 1 week: p<.001) included breathing exercises Intervention setting: using volumetric spirometry Baseline measures comparable Peak expiratory flow (liters): Hospital and progressively increasing between groups: Yes G1: 4.7 ± 1.4 (5-10 cm H20) EPAP, 15-20 G2: 5.2 ± 1.8 minutes/session twice/day Age, mean years ± SD: Study Design: until hospital discharge + G1: 62 ± 6 Functional residual capacity (liters): RCT continuation at home post- G2: 60 ± 7 G1: 2.8 ± 0.8 discharge G2: 3.0 ± 0.9 Underlying condition(s), %: Comparator: Control-- Ischemic heart disease Exercise tolerance (6-minute walk test): coughing and breathing G1+G2: 100 G1>G2, p<.0001 exercises + early mobilization Mechanical ventilation, n: Groups/n: G1+G2: 0 One-month Followup G1: IS/EPAP/21 Total lung capacity (liters): G2: Control/22 G1: 5.5 ± 1.2 (1 week vs. 1month: p<0.01) G2: 5.1 ± 0.8 (baseline vs. 1 month: p<.05) Followup: 7 days, 1 month post-CABG Peak expiratory flow (liters): G1: 6.5 ± 1.9 % available at 1-month G2: 6.1 ± 2.0 follow-up: G1: 81 Functional residual capacity (liters): G2: 77 G1: 3.1 ± 0.9 G2: 3.2 ± 0.7

Exercise tolerance (6-minute walk test): G1>G2, p<.0001

Length of stay-hospital (mean days): G1: 7 G2: 7.47 G1 vs. G2: p<.002

Appendix-122

Intervention(s)/ Study Description Patient Population Outcomes (definition) and Effect Comparator(s) Author: Intervention: CPT (thoracic Description of population: Elective Median time (50% of pts in each group) to Templeton et al., 2007 and pulmonary expansion, and emergency adult patients become ventilator free, days (range): respiratory muscle exercise, intubated and ventilated for >48 hrs G1: 15 (3-82) Country: UK mobilization, and secretion and likely to remain ventilated G2: 11 (3-76) removal via manual G1 vs. G2: p=0.045 Intervention setting: hyperinflation, vibration, Baseline measures comparable ICU positioning, and suctioning) between groups: Yes Median length of ICU stay, days (range): G1: 13 (3-82) Study Design: Comparator: Suctioning, Age, mean years ± SD: G2: 12 (4-76) RCT general decubitus care and G1: 57.7 ± 16.5 G1 vs G2: p=NS mobilization as needed G2: 58.2 ± 18.0 Patients requiring re-ventilation after Groups/n: Underlying condition(s), n: becoming ventilator free, n (%): G1: CPT/91 Respiratory insufficiency G1: 11 (12.6) G2: Suctioning only/89 G1: 13 G2: 12 (14.1) G2: 8 G1 vs G2: p=NS Followup: Up to ICU discharge or death Cardiac insufficiency Median time to become re-ventilated, days G1: 9 (range): % available at follow-up: G2: 8 G1: 1 (1-9) G1: 96 G2: 3.5 (1-6) G2: 96 Head trauma G1 vs G2: p=NS G1: 2 G2: 3

Intracerebral hemorrhage G1: 22 G2: 13

Multiple trauma G1: 2 G2: 5

Sepsis G1: 16 G2: 16

Peripheral vascular surgery G1: 2 G2: 4

Hemorrhagic shock

Appendix-123

Intervention(s)/ Study Description Patient Population Outcomes (definition) and Effect Comparator(s) G1: 11 G2: 14

GI bleed, perforation, obstruction, or surgery G1: 8 G2: 10

Acute pancreatitis G1: 0 G2: 1

Viral encephalitis G1: 1 G2: 1

Seizures G1: 1 G2: 2

Mechanical ventilation, %: G1+G2: 100

Appendix-124

Intervention(s)/ Study Description Patient Population Outcomes (definition) and Effect Comparator(s) Author: Intervention: Intrapulmonary Description of population: Mean difference (95% CI), p Clini et al., 2006 Percussive Ventilation (IPV) Tracheostomized adults recently 10 mins twice/day + CPT (60 weaned from mechanical ventilation, PaO2 (mmHg): Country: Italy min session twice/day) for 15 breathing spontaneously for 72 hrs, 2.32 (-6.91 to 11.56), NS days and with sputum production >40 Intervention setting: ml/day PaCO2 (mmHg): Ventilator weaning unit Comparator: CPT, two 60 -5.54 (-12.73 to 1.65), NS min sessions/day for 15 days Baseline measures comparable Study Design: between groups: Yes PaO2/FIO2: RCT Groups/n: 21.65 (-11.75 to 55.05), p=0.038 G1: IPV+CPT/24 Age, mean years ± SD: G2: CPT only/22 G1: 68 ± 10 Maximal expiratory pressure (cmH2O): G2: 70 ± 8 9.26 (1.98 to 16.54), p=0.014 Followup: after 15 days of treatment (pulmonary and Underlying condition(s), n (%): 30-day followup oxygenation outcomes), COPD Adverse events, n: 1month post-treatment G1: 6 (25) Acute hemorrhage (respiratory complications) G2: 5 (23) G1: 0 G2: 0 % available at follow-up: Chronic respiratory insufficiency G1: 96 G1: 6 (25) Nosocomial pneumonia G2: 95 G2: 5 (23) G1: 0 G2: 2 Pulmonary fibrosis G1: 2 (8) Atelectasis G2: 1 (4) G1: 0 G2: 0 Cardiac surgery G1: 3 (13) G2: 3 (14)

Pneumonectomy/lobectomy G1: 2 (8) G2: 2 (9)

Sepsis G1: 1 (4) G2: 2 (9)

Neurologic events/diseases G1: 4 (17) G2: 4 (18)

Appendix-125

Intervention(s)/ Study Description Patient Population Outcomes (definition) and Effect Comparator(s)

Mechanical ventilation, n: G1+G2: 0

Appendix-126

Intervention(s)/ Study Description Patient Population Outcomes (definition) and Effect Comparator(s) Author: Antonaglia et Intervention: IPV (two 25 to Description of population: Adults PaCO2 (mmHg), mean ± SD: al., 2006 30-min sessions) + helmet with acute COPD exacerbation G1: 58 ± 5.4 NPPV requiring ventilatory assistance G2: 64 ± 5.2 Country: Brazil Comparator: CPT (chest Baseline measures comparable PaO2/FiO2 (def), mean ± SD: Intervention setting: clapping, postural drainage between groups: Yes G1: 274 ± 14.8 ICU and mobilization, expiration G2: 218 ± 34.2 with glottis open, 10 mins Age, mean years ± SD: Study Design: each for total of 25-30 mins) + G1: 72 ± 7 Mean arterial pressure (mmHg), mean ± SD: RCT helmet NPPV G2: 69 ± 7 G1: 82 ± 3.6 G2: 81 ± 3.4 Groups/n*: Underlying condition(s), n: G1: IPV+NPPV/20 COPD Respiratory rate (min), median (25th-75th G2: CPT+NPPV/20 G1: 20 percentile): G2: 20 G1: 24 (22-24) Followup: Until ICU G2: 25 (24-26) discharge Hypersecretion (≥30 mL secretions/day) Heart rate (min), median (25th-75th percentile): % available at follow-up: G1: 14 G1: 81 (80-85) G1: 65 G2: 13 G2: 81 (79-89) G2: 65 Mechanical ventilation, %: Duration of ventilatory assistance (hours), G1+G2: 100 median (25th-75th percentile): G1: 61 (60-71) G2: 89 (82-96)

Length of ICU stay (days), median (25th-75th percentile): G1: 7 (6-8) G2: 9 (7.75-9.5)

*Note: Study also includes a historical control group; data not extracted here.

Appendix-127

Intervention(s)/ Study Description Patient Population Outcomes (definition) and Effect Comparator(s) Author: Intervention: Intrapulmonary Description of population: Adults Mean ± SD: Vargas et al., 2005 Percussive Ventilation (IPV), with acute COPD exacerbation and 30 mins twice/day + standard mild respiratory acidosis PaCO2 (Torr): Country: France care (mean duration 3 ± 1 G1: 53.5 ± 2.3 (baseline vs. followup: p<0.05) days) Baseline measures comparable G2: NR Intervention setting: between groups: Yes ICU Comparator: Standard care PaO2 (Torr): G1: 61.0 ± 0.8 (baseline vs. followup: p<0.05) Study Design: Groups/n: Age, mean years ± SD: G2: NR RCT G1: Standard Rx + IPV/16 G1: 69.2 ± 6.0 G2: Standard care/17 G2: 70.2 ± 5.0 Respiratory rate (breath/min): G1: 31 ± 2 (baseline vs. followup: p<0.05) Followup: Immediate post Underlying condition(s), %: G2: NR first IPV session COPD G1+G2: 100 Length of stay-hospital (days): % available at follow-up: G1: 6.8 ± 1.0 G1: 100 Mechanical ventilation (NIV), n: G2: 7.9 ± 1.3 G2: 100 G1: 0 G1 vs. G2: p <0.05 G2: 6

Appendix-128

Intervention(s)/ Study Description Patient Population Outcomes (definition) and Effect Comparator(s) Author: Unoki et al., Intervention: Chest Description of population: ICU Mean ± SD 2005 compression + patients likely to require mechanical suctioning/Suctioning without ventilation >48 hours PaO2/FIO2 (mm Hg): Country: Japan compression (G1a) G1a: 300.2 ± 86.7 Baseline measures comparable G1b: 301.9 ± 82.0 Intervention setting: Comparator: Suctioning between groups: NR G1a vs. G1b: p=NS ICU without compression/Compression + PaCO2 (mm Hg): Study Design: suctioning (G1b) Age, mean years ± SD: G1a: 38.6 ± 7.4 RCT—crossover G1a+G1b: 56.7 ± 17.6 G1b: 39.3 ± 6.8 Both sequences performed on G1a vs. G1b: p=NS the same day with minimum 3 hour interval Underlying condition(s), n (%): Respiratory compliance (L/cm H2O): G1+G1b G1a: 39.8 ± 14.4 Groups/n: Intracerebral hemorrhage: 6 (19.4) G1b: 41 ± 14.1 G1a+G1b: 31 Cardiac arrest: 6 (19.4) G1a vs. G1b: p=NS Pneumonia: 4 (12.9) Followup: 25 minutes Cerebral infarction: 4 (12.9) Sputum clearance (weight in grams)*: following intervention or Aneurysmal Subarachnoid G1a vs. G1b: NS control sequence hemorrhage: 3 (9.7) Sepsis: 3 (9.7) % available at follow-up: Head injury: 2 (6.5) G1a+G1b: 100 Other: 3 (9.7)

Mechanical ventilation, n: G1a+G1b: 31

*Data reported in figure only

Appendix-129

Study Description Intervention(s)/ Comparator(s) Patient Population Outcomes (definition) and Effect Author: Intervention: Deep breathing Description of population: Adults (29- Mackay et al., 2005 exercises and coughing + 91 years) undergoing open abdominal Length of stay (days), mean ± SD, (range): mobilization , 3 times daily on surgery G1: 10.4 ± 3.0 (6-21) Country: Australia postoperative day 1 and 2, twice G2: 13.3 ± 4.5 (5-23) daily on days 3 and 4, then daily Baseline measures comparable Difference: 2.9 , p=0.008 Intervention setting: until patient was able to move between groups: yes 95%CI: (0.77 to 5.03) Hospital surgical independently and had clear chest department for 3 consecutive days. Age, years (mean ± SD): ICU stay (days), mean (n patients) : G1: 63 ± 13 G1: 2.5 (2) Study Design: Comparator: Mobilization only G2: 69 ± 15 G2: 2.0 (3) RCT (walk, active ankle plantar flexion G1 vs. G2: p=NS and dorsiflexion exercise at least 20 Underlying condition, n (%): times every waking hour) Cardiac disease: Mechanical ventilation (days), mean (n G1:11 (38) patients): Groups/n: G2:9 (43) G1: 0.75 (2) G1: Deep breathing and G2: 2.0 (n2) coughing/29 Liver disease: G1 vs. G2: p=NS G2: Mobilization only/21* G1: 4 (14) G2: 4 (19) Postoperative pulmonary complications, n Followup: At discharge (%): Renal disease: G1: 5 (17) % available at follow-up: G1: 4 (14) G2: 3 (14) G1: 100 G2: 2 (10) Difference between means: -0.03 G2: 100* (95%CI: -0.22 to 0.19) History of cancer: G1: 16 (55) G2: 12 (57)

Musculoskeletal problems: G1: 10 (35) G2: 7 (33)

Stroke/TIA: G1: 2(7) G2: 1 (5)

Diabetic: G1: 5 (17) G2: 4 (19)

Mechanical ventilation, %: G1+G2: Percent NR; at least 2 patients in each group required mechanical

Appendix-130

Study Description Intervention(s)/ Comparator(s) Patient Population Outcomes (definition) and Effect ventilation during the study

* Includes data from one patient who mistakenly received deep breathing exercises on Day 1 post-surgery. The investigators note that this patient was retained in the mobilization group and the data analyzed by ITT.

Appendix-131

Study Description Intervention(s)/ Comparator(s) Patient Population Outcomes (definition) and Effect Author: Intervention: Combinations of Description of population: Adults (21- Mean ± SD Tsang et al., 2003 postural drainage, breathing and 65 years) with acute exacerbation of coughing manoeuvres or Flutter; bronchiectasis Duration of hospital stay (days): Country: Hong Kong postural drainage for 15 minutes+ G1: 7.2 ± 3.3 breathing/coughing every 3 Baseline measures comparable G2: 6.2 ± 3.83 Intervention setting: minutes. Flutter for 15 between groups: Yes G3: 5.2 ± 0.84 Hospital minutes+breathing/coughing every No significant difference between groups 3 minutes. Breathing/coughing Study Design: alone consisted of deep Age, years (mean ± SD): No significant differences in sputum production RCT breaths+cough every 3 minutes for G1: 66.80 ± 15.48 (wet weight) or lung function parameters (FVC, 15 minutes. All protocols done 3 G2: 72.40 ± 5.27 FEV1, PEFR) among the 3 groups times / day from day 2 to discharge G3: 74.20 ± 6.37 Day of discharge: Groups/n: Underlying condition, %: Wet sputum weight (g): G1: Postural Bronchiectasis G1: 34.99 ± 34.65 drainage+breathing/coughing / 5 G1+G2+G3:100 G2: 13.96 ± 12.60 G2: Flutter+breating/coughing / 5 G3: 19.48 ± 18.97 G3: Breathing/coughing alone/ 5 Mechanical ventilation, n: G1+G2+G3: 0 PEFR (L/min): Followup: at discharge G1: 141.2 ± 49.65 G2: 118 ± 51.59 % available at follow-up: G3: 138.6 ± 79.8 G1+G2+G3: 100 FEV1 (L): G1: 0.83 ± 0.43 G2: 0.65 ± 0.19 G3: 0.61 ± 0.31

FVC (L): G1: 1.19 ± 0.68 G2: 1.07 ± 0.28 G3: 0.89 ± 0.45

No changes in heart rate or oxygen saturation in any of the groups

Appendix-132

Study Description Intervention(s)/ Comparator(s) Patient Population Outcomes (definition) and Effect Author: Intervention: Flutter therapy 15-20 Description of population: Children Mean ± SEM Samransamruajkit et al., minutes daily for 3 days + standard (6-16 years) with uncomplicated acute 2003 medical therapy Asthma Oxygen saturation, %: G1, n=5: 97.8 ± 0.4 Country: US Comparator: Standard medical Baseline measures comparable G2, n=5: 96.4 ± 0.8 therapy only between groups: Yes except for initial Intervention setting: asthma score (p<0.01) and oxygen FiO2, %: Tertiary care hospital Groups/n: requirement (FiO2, p<0.05) which were G1, n=5: 21 ± 0.00 G1: Flutter + standard /20 higher in G1 G2, n=5: 21.5 ± 0.5 Study Design: G2: Standard therapy/20 RCT (open label) Age, years (mean ± SEM): Followup: At discharge G1: 9.19 ± 0.42 Length of stay (days): G2: 10.82 ± 0.7 G1: 2.27 ± 0.13 % available at follow-up: G2: 2.47 ± 0.13 G1:25 Underlying condition, n (%): p=NS G2:25 Atelectasis: G1: 5 (25) Adverse events: G2: 5 (25) G1: 0 G2: NA Lung hyperinflation: G1: 9 (45) Pulmonary Function: G2: 8 (40) FVC, FEV1 significantly increased in G1 compared to G2 in the 1st and 2nd hospital days (p<0.05), but not significant on the 3rd day of Mechanical ventilation, n: hospitalization (n=5 in each group). G1+G2: 0 Data reported only in graphs

Appendix-133

Intervention(s)/ Study Description Patient Population Outcomes (definition) and Effect Comparator(s) Author : Intervention: CPT (drainage Description of population: Ventilation duration (days), median (range): Ntoumenopoulos et al., or sidelying positioning for at Intubated, mechanically ventilated (≥ G1: 4.4 (2-31) 2002 least 20 mins, four sets of six 48 hours) adult ICU patients G2: 5.2 (2.2-20) cycles of expiratory chest wall G1 vs. G2: p=NS Country: Australia vibrations, and airway Baseline measures comparable suctioning (at least three between groups: Yes for VAP risk ICU duration (days), median (range): Intervention setting: times) 2x/day factors but ASA score significantly G1(n=18): 5.6 (2-35) ICU higher in G2 G2 (n=33): 5.8 (2.6-25) Comparator: Sham CPT Study Design: (cardiopulmonary Age, mean years ± SD: RCT assessment, musculoskeletal G1: 65.0 ± 14.3 PT) G2: 65.1 ± 14.6

Groups/n: Underlying condition(s), n (%): G1: CPT/24 Chronic obstructive airway disease G2: Control/sham CPT/36 G1: 6 (25.6) G2: 11 (30.6) Followup: ICU discharge and at 28 days* Cardiomyopathy G1: 1 (4.2) % available at follow-up G2: 3 (8.3) (ventilation outcome): G1: 100 Cardiac arrest G2: 100 G1: 3 (12.5) G2: 5 (13.9)

Mechanical ventilation, %: G1: 100 G2: 100 *followed up for any mortality at 28 days

Appendix-134

Intervention(s)/ Study Description Patient Population Outcomes (definition) and Effect Comparator(s) Author: Berney et al., Intervention: Postural Description of population: Sputum production (grams), mean difference 2002 drainage + manual Intubated, ventilated, cardiovascularly (95% CI): hyperinflation+ suctioning in stable patients 2.65 (1.79 to 3.54) Country: Australia sidelying position (6 sets of 6 p=NS manual hyperinflation breaths) Baseline measures comparable Intervention setting: between groups: NR Sputum wet weight (grams), mean (95% CI): ICU Comparator: Postural G1a: 6.53 (5.86 to 7.20) drainage + ventilator Age, mean years (range): G1b: 6.01 (4.83 to 7.19) Study Design: hyperinflation+ suctioning in G1a + G1b: 45.2 (16-86) G1a vs. G2b: p=NS RCT—Double sidelying position (6 sets of 6 crossover ventilator hyperinflation Underlying condition(s), n: Static pulmonary compliance (ml/cm H2O), breaths) G1a+G1b mean, mean percentage improvement (95% Respiratory failure: 1 CI): Patients received each Spinal injury: 12 G1a: 50.7, 9.7% (46.5 to 54.9) sequence once, 2 hours apart, Multiple trauma: 4 G1b: 50.1, 11.6% (45.5 to 54.7) on 2 consecutive days Guillain-Barre: 1 p (G1a, G1b vs. baseline): <0.001 Sepsis/pneumonia: 1 Groups/n: Gastrectomy: 1 G1a: Manual hyperinflation G1b: Ventilator hyperinflation Mechanical ventilation, %: G1a+G1b=20 G1a+G1b: 100

Followup: 30 minutes post- treatment

% available at follow-up: G1a+G1b: 100

Appendix-135

Intervention(s)/ Study Description Patient Population Outcomes (definition) and Effect Comparator(s) Author: Bellone et al., Intervention*: PEP + assisted Description of population: Adults Sputum production (grams), mean ± SD: 2002 coughing (2 min tidal volume+ with acute hypercapnic respiratory G1: 13.2 ± 4.1 assisted coughing + 2 min failure due to COPD exacerbation G2: 5.2 ± 1.9 Country: Italy undisturbed breathing and copious bronchial secretions G1 vs. G2: NR repeated 5-7 times for a total Intervention setting: of 30-40 min over 72 hrs) Baseline measures comparable Time to ventilator weaning (days), mean ± SD: Respiratory ICU between groups: Yes G1: 4.9 ± 0.8 Comparator: Assisted G2: 7.0 ± 0.7 Study Design: coughing alone Age, mean years ± SD: G1 vs. G2: p<0.01 RCT G1: 65 ± 7.8 Groups/n: G2: 64 ± 7.7 Need for intubation, n: G1: PEP + Assisted coughing G1: 0 /13 Underlying condition(s): G2: 1 G2: Assisted coughing/14 Chronic corpulmonale, n (%): G1 vs. G2: p=NS G1: 10 (77) Followup: 1 hour after end of G2: 12 (86) SaO2: treatment No significant change in SaO2 in either group (no Mechanical ventilation (NPPV), %: data provided) % available at follow-up: G1: 100 G1: 100 G2: 100 Adverse events, n (%): G2: 100 Discomfort related to PEP mask G1: 2 (15.3) G2: NA

*All patients also received standard medical therapy including nebulized salbutamol and ipratropium bromide, methylprednisolone, and antibiotics

Appendix-136

Study Description Intervention(s)/ Comparator(s) Patient Population Outcomes (definition) and Effect

Author: Intervention: Positioning (left and Description of population: PaCO2 (mmHg), mean: Barker et al., 2002 right lateral decubitus, no Mechanically ventilated adults with G1: 46.436 elevation)+suctioning OR positioning acute lung injury G2: 47.3 Country: UK (left and right lateral decubitus, no G3: 42.378 elevation)+suctioning+manual Baseline measures comparable p (among groups, within groups)=NS Intervention setting: hyperinflation (6 breaths prior to between groups: Yes ICU suctioning) Dynamic pulmonary compliance Age, mean years ± SD: (ml/cmH2O), mean: Study Design: Comparator: Supine G1: 70 ± 7.4 G1: 27.326 RCT positioning+suctioning G2: 70 ± 16.3 G2: 35 G3: 73 ± 2.6 G3: 45.436 Groups/n: p (among groups, within groups)=NS G1: Decubitus Underlying condition(s), n: positioning+suctioning/5 G1+G2+G3: Heart rate (BPM), mean: G2: Decubitus Sepsis: 7 G1: 91.2 positioning+suctioning+hyperinflation/7 Aspiration pneumonia: 5 G2: 96.3 G3: Supine positioning+suctioning/5 Community-acquired pneumonia: 4 G3: 89.8 Pancreatitis: 1 p (among groups, within groups)=NS Followup:1 hour post-treatment (mean treatment time across Mechanical ventilation, %: Mean arterial pressure (mmHg), mean: groups=12.9 min ± 5.9 ) G1+G2+G3: 100 G1: 87.18 G2: 74.6 % available at follow-up: G3: 83.64 G1: 100 p (among groups, within groups)=NS G2: 100 G3: 100

Appendix-137

Study Description Intervention(s)/ Comparator(s) Patient Population Outcomes (definition) and Effect Author: Intervention: 2 doses of Periodic Description of population: Adults (58- 5th postoperative day, mean ± SD : Denehy et al., 2001 Continuous Positive Airway 83 years) admitted for elective upper Pressure (PCPAP) , 4 times daily abdominal surgery and with FEV1 Pulmonary function: Country: Australia for 3 days + traditional >50% of predicted value Functional residual capacity: physiotherapy, 2 times daily for 3 G1 (n=15): 88.2 ± 18.2 Intervention setting: post operative days Baseline measures comparable G2 (n=12): 90.5 ± 20.7 Inpatient hospital (Surgical between groups: Yes G3 (n=13): 78.0 ± 19.5 admissions) Comparator: Traditional No significant difference between groups and for physiotherapy (PT) only (deep Age, mean years ± SD: group X time interaction Study Design: breathing instruction, FET, G1: 72.5 ± 6.5 Significant change across time: p=0.002 RCT supported coughing), twice daily for G2: 70.5 ± 6.3 a minimum of 10 minutes for 3 post- G3: 73.3 ± 5.8 Vital capacity: operative days G1 (n=15): 82.5 ± 13.7 Underlying condition, n (%): NR G2 (n=12): 77.1 ± 10.2 Groups/n*: G3 (n=13): 86.8 ± 17.1 G1: PCPAP for 15 minutes +PT/17 Mechanical ventilation: Between group difference =ns G2: PCPAP for 30 minutes +PT/15 G1-G3: NR Significant change across time: p<0.001 G3: PT only/18 Oxygen saturation, SpO2: Followup: 5th postoperative day G1 (n=14): 96 ± 1.7 G2 (n=13): 95 ± 1.3 % available at follow-up: G3 (n=16): 94 ± 2.2 G1-G3: 87.7 Between group differences =ns Significant change across time: p=0.0001

Length of stay (LOS)-hospital (days): G1 (n=17): 11.5 ± 4.1 G2 (n=15): 12.5 ± 4.8 G3 (n=18): 123 ± 4.8 No between group difference in mean LOS (p=0.71) Longer LOS (13 vs.11 days) in those with pulmonary complications: p=0.02

Incidence of Post-operative pulmonary complications (%): Overall: 14 G1:11 G2: 6 G3: 22 *(N=58 enrolled)

Appendix-138

Study Description Intervention(s)/ Comparator(s) Patient Population Outcomes (definition) and Effect Author: Intervention: Rx-twice daily- Description of population: Intubated Median difference (baseline to post-final Krause et al., 2000 postural drainage for 15 min, children and adults with acute lobar treatment, as reported in study*) percussion for 5 min, followed by atelectasis Country: South Africa suction procedure. Drainage PaO : position based on the collapsed Baseline measures comparable 2 Intervention setting: ICU lung lobe between groups: Yes G1: 21,00 G2: 1,00 Study Design: Comparator: Modified postural Age, years (range): RCT drainage position, followed by 13-85 SaO2 : treatment identical to intervention G1: 2,15 group Underlying condition, n : G2: 0,10 Guillian-Barre Syndrome:

Groups/n: G1: 0 G1: Postural drainage + percussion G2: 1 + suction /9 No statistical significance reported G2: Modified postural drainage + Obstruction of bronchi/bronchioles: percussion + suction / 8 G1: 1 G2: 1

Followup: Immediately post- Pleural effusion: treatment G1:1 G2: 2 % available at follow-up: G1+G2: 100 Pneumothorax / hemothorax: G1: 2 G2: 1

Mechanical ventilation, n: G1+G2: 0

*data not clearly reported

Appendix-139

Study Description Intervention(s)/ Comparator(s) Patient Population Outcomes (definition) and Effect Author: Intervention: Cough assist, walk Description of population: Children Mean ± SD Charmoy et al., 2000 assist and breathing exercises and adults (11-63 years) with given twice daily on post-op day 1 uncomplicated cardiac valvular surgery Respiratory rate (breaths/min): Country: South Africa and 2 and once daily on 3rd and 4th G1: 21.86 ± 6.59 post-op days Baseline measures comparable G2: 22.86 ± 4.62 Intervention setting: between groups: Yes p=NR Hospital surgical ward Comparator: Instructions for coughing after surgery, mobilization Age, years (mean ± SD): PaO2: Study Design: on 2nd day after surgery G1: 31 ± 15.21 G1: 60.35 ± 14.10 RCT G2: 28.43 ± 11.12 G2: 58.91 ± 9.27 Groups/n: G1 vs. G2: p=NS G1: Cough assist+breathing Underlying condition, n (%): exercise / 16 NR % Saturation: G2: Instructions for coughing / 14 G1: 91.98 ± 4.09 Mechanical ventilation: G2: 92.02 ± 4.64 Followup: day 4 post-op NR p=NR

% available at follow-up: P(alveolar-arterial)02: G1+G2: 100 G1: 54.24 ± 7.87 G2: 53.13 ± 8.83 p=NR

Length of stay (LOS)-hospital: Not significantly different between groups (data not reported)

Pulmonary complications: G1+G2: 0 participants developed pulmonary complications (fever > 38.5 degrees, evidence of consolidation or collapse on X-ray and infection clinically)

Appendix-140

Study Description Intervention(s)/ Comparator(s) Patient Population Outcomes (definition) and Effect Author: Intervention: Manual hyperinflation Description of population: Adult, Pulmonary Function (mean ± SD): Ntoumenopoulos et al., (MHI) twice daily with postural intubated, mechanically ventilated Worst daily PaO2 / FiO2, day 4 : 1998 drainage (PD) for 20 minutes, twice trauma patients G1 (n=12): 258.2 ± 93.1 daily G2 (n=9): 305 ± 176.9 Country: Australia Baseline measures comparable G1 vs. G2: p=NS Comparator: No MHI / PD unless between groups: Yes Intervention setting: developed nosocomial pneumonia Days in ICU (mean ± SD): Trauma ICU Age, years (mean ± SD): G1: 7.4 ± 5.7 Both groups received 2 hourly G1: 38.95 ± 16.62 G2: 6.8 ± 4.6 Study Design: patient turns, airway suctioning and G2: 41.20 ± 20.15 G1 vs. G2: p=NR RCT musculoskeletal physiotherapy Underlying condition, n (%): Groups/n: NR G1: Chest Physiotherapy/22 G2: Control/24 Mechanical ventilation, %: G1+G2: 100 Follow-up: Until ICU discharge

% available at follow-up: G1: 81.8 G2: 66.7

Appendix-141

Study Description Intervention(s)/ Comparator(s) Patient Population Outcomes (definition) and Effect Author: Intervention: CPT (information on Description of population: Adult Duration of hospital stay (days): Olsen et al., 1997 early mobilization, breathing (19-92 years) patients undergoing G1(n=172): 8.8 ± 4.5 exercise (30 deep breaths), huffing, elective abdominal surgery G2 (n=192): 9.0 ± 5.1 Country: Sweden coughing and PEP for high risk G1 vs. G2: p=NS patients* for 10-15 min before and Baseline measures comparable Intervention setting: 15-20 min after operation between groups: Yes Oxygen saturation: Gastroenterological unit G1 >G2 on day 1 (p<0.001) and days 2 and 3 Comparator: No information / Age, years (mean ± SD): (p<0.05) Study Design: treatment except for those with G1: 53.5 ± 17.4 RCT pulmonary complication G2: 52.9 ± 17.5 O2 saturation=89%, n: G1: 1 Groups/n: Underlying condition, n (%): G2: 19 G1: CPT /174 Overweight: G2: Control / 194 G1: 37 (21) Pulmonary function: G2: 48 (25) Reduction in FVC and PEFR post-operatively in Follow-up: 6 days after surgery both groups (p=NS) Lung disease: % available at follow-up: G1: 18 (10) Postoperative pulmonary complications, %: G1: 98.9 G2: 23 (12) G1 (n=172): 6 G2: 99.0 G2 (n=192): 27 High risk patients: G1 vs. G2: p<0.001 G1: 40 (23) G2: 39 (20) G1 high risk/n: 6/40 G2 high risk/n: 20/39 Mechanical ventilation: G1 vs. G2: p<0.001 NR G1 low risk/n: 4/132 G2 low risk/n: 32/153 G1 vs. G2: p<0.001

Diagnosis of pneumonia, n: G1: 1 G2: 13 G1 vs. G2: p<0.05

* high risk patients (age >50 years and at least one of the following: smoker/ex-smoker for <12 months, BMI > 30kg/m2, pulmonary disease with a need for daily medication and a history of other medical condition causing reduced ventilator function); PEP=positive expiratory pressure

Appendix-142

Study Description Intervention(s)/ Comparator(s) Patient Population Outcomes (definition) and Effect Author: Intervention: Early mobilization + Description of population: Adults Pulmonary function: Johnson et al., 1996 deep breathing + sustained undergoing elective cardiac valve FVC, L (mean ± SD): maximal inspiration* surgery G1: 2.1 ± 1.0 Country: Canada G2: 1.7 ± 0.5 Comparator: Early mobilization + Baseline measures comparable Intervention setting: deep breathing + sustained between groups: Yes, except for age FRC, L (mean ± SD): Tertiary care hospital maximal inspiration + single-handed (higher in G2 by approximately 5 years) G1: 3.1 ± 0.7 percussion, 2 sessions daily** G2: 2.4 ± 0.7 Study Design: Age, years (mean ± SD): RCT Groups/n: G1: 63 ± 12 FEV1, L (mean ± SD): G1: Early mobilization + deep G2: 68 ± 10 G1: 1.6 ± 0.8 breathing + sustained maximal G1 vs. G2: p=0.044 G2: 1.3 ± 0.4 inspiration / 41 G2: Early mobilization + deep Underlying condition, n (%): No group difference in post operative FVC and breathing + sustained maximal Stroke : FEV1 reduction inspiration + percussion /34 G1: 3 (7.3 ) G2: 4 (11.8) Dco, mL/min/mm Hg (mean ± SD): Followup: Until discharge G1: 15 ± 5 Mechanical ventilation, n: G2: 10 ± 2.4 % available at follow-up: G1+G2: 0 G1 vs. G2: p<0.05 G1+G2: 100 Negative inspiratory pressure (cm H2O): G1: 39 ± 19 G2: 33 ± 14 G1 vs. G2: p<0.05

Length of hospital stay (days) (mean ± SD): G1: 8.3 ± 2.8 G2: 8.3 ± 1.3 P=ns

Elevated heart rate (>120 beats/min), n: G1: 0 G2: 1 G1 vs. G2: p=ns * Stacked inhalations to total lung capacity with a five-second breath hold for five repetitions and conducted once each waking hour ** One to two cupped hand percussions/second to the chest wall during the total lung capacity phase of a sustained maximal inspiration

Appendix-143

Study Description Intervention(s)/ Comparator(s) Patient Population Outcomes (definition) and Effect Author: Minimal atelectasis: Description of population: Adults Pulmonary function: Johnson et al., 1995 Early ambulation plus deep undergoing elective aortocoronary At discharge, lung volumes and spirometry values breathing OR early ambulation plus artery bypass surgery similar between groups (p>0.05) Country: Canada deep breathing plus sustained maximal inspiration* Baseline measures comparable FVC, L (mean ± SD): Intervention setting: ICU between groups: Yes G1: 2.7 ± 0.7 Marked atelectasis: G2: 2.8 ± 0.5 Study Design: Early ambulation plus deep Age, years (mean ± SD): G3: 2.8 ± 0.6 RCT breathing plus sustained maximal G1: 60± 10 G4: 3.0 ± 0.6 inspiration OR early ambulation G2: 64 ± 11 Note: see related study plus deep breathing plus sustained G3: 66 ± 8 FRC, L (mean ± SD): Johnson et al., 199618 maximal inspiration plus G4: 64 ± 11 G1: 2.9 ± 0.8 percussion** G2: 3.4 ± 0.8 Underlying condition, n (%): G3: 3.3 ± 0.8 Groups/n: Stroke : G4: 3.8 ± 1.0 G1: early mobilization + deep G1: 1 (2.1 ) breathing / 48 G2: 1 (2.0) FEV1, L (mean ± SD): G2: early mobilization + deep G3: 4 (6.3 ) G1: 1.8 ± 0.5 breathing + sustained maximal G4: 1 (1.6 ) G2: 1.7 ± 0.5 inspiration (minimal atelectasis / 49 G3: 1.8 ± 0.5 G3: early mobilization + deep Diabetes, n (%): G4: 2.0 ± 0.6 breathing + sustained maximal G1: 10 (20.8) inspiration (marked atelectasis) / 64 G2: 5 (10.2) DLco, mL/min/mm Hg (mean ± SD): G4: early mobilization + deep G3: 15 (23.4) G1: 15 ± 3.5 breathing + sustained maximal G4: 7 (11.1) G2: 15 ± 2.9 inspiration + percussion / 63 G3: 15 ± 3.3 Mechanical ventilation: G4: 15 ± 3.9 Followup: Until discharge NR Negative inspiratory pressure (cm H2O): % available at follow-up: G1: 57 ± 22 G1+G2+G3+G4: 96.4 G2: 54 ± 30 G3: 60 ± 31 G4: 58 ± 31

Length of hospital stay (days), (mean ± SD): G1: 8 ± 1.5 G2: 8 ± 1.6 G3: 9 ± 2.7 G4: 10 ± 8.5 G1,G2 vs. G3, G4: p<0.05

ICU, days, (mean ± SD): G1: 2.0 ± 0.5

Appendix-144

Study Description Intervention(s)/ Comparator(s) Patient Population Outcomes (definition) and Effect G2: 2.1 ± 0.5 G3: 2.3 ± 0.8 G3: 2.3 ± 0.6 G1, G2 vs. G3, G4: p<0.05

Pneumonia (n meeting criteria): G1: 8 G2: 10 G3: 14 G4: 13 P=NS

* Stacked inhalations to total lung capacity with a five-second breath hold for five repetitions and conducted once each waking hour ** One to two cupped hand percussions/second to the chest wall during the total lung capacity phase of a sustained maximal inspiration, 3 sessions/day

Appendix-145

Study Description Intervention(s)/ Comparator(s) Patient Population Outcomes (definition) and Effect

Author: Intervention: Oscillatory PEP Description of population: Adult in- FEV1 (liters), mean ± SD: Ambrosino et al., 1995 (flutter VRP1), 2 sessions to a patients with high sputum (>25 ml / G1a: 1.03 ± 0.6 maximum of 30 minutes day) production due to diseases other G1b: 1.07 ± 0.6 Country: Italy than cystic fibrosis G1 vs. G2: p=NS Comparator: Postural drainage + Intervention setting: percussion, 2 sessions Baseline measures comparable FVC (liters), mean ± SD: Hospital between groups: Yes G1a: 1.85 ± 0.7 Sessions occurred over 8 days with G1b: 1.83 ± 0.6 Study Design: washout day between each Age, years (mean ± SD): G1 vs. G2: p=NS RCT-crossover G1a+G1b: 65 ± 16 Groups/n: Peak expiratory flow rate (liters min-1), mean ± G1a: Oscillatory PEP Underlying condition, n (%): SD: G1b: Postural drainage + COPD: 8 ( 57.1) G1a: 148 ± 89 percussion Bronchiectasis: 2 (14.3) G1b: 163 ± 92 G1a+G1b: n=14 Silicosis: 1 (7.1) G1 vs. G2: p=NS Chronic bronchitis: 3 (21.4) Followup: 60 minutes after Oxygen saturation, %: completing each treatment Mechanical ventilation: G1a: 93 ± 3 NR G1b: 94 ± 2 % available at follow-up: G1 vs. G2: p=NS G1a+G1b=100 Sputum production (ml), mean ± SD: G1a: 3.4 ± 2.3 G1b: 4.9 ± 5.3 Significant reduction in both groups at followup vs. immediately after treatment (p<0.001)

Improvement in chest unpleasantness due to sputum (25 cm VAS), mean ± SD:* G1a: 37.5 ± 11 (Time 0 to immediately after treatment, p<0.001) G1b: 35 ± 16 (Time 0 to immediately after treatment, p<0.001)

Adverse effects: None observed during treatments

*Values reported are for immediately post-treatment; study notes that values at 60 mins post-treatment were “still observed” but actual data not reported

Appendix-146

Study Description Intervention(s)/ Comparator(s) Patient Population Outcomes (definition) and Effect Author: Asher et al., 1990 Intervention: CPT (positioning, Description of population: Children Mean ± SD breathing exercises, relaxation, (6-13 years) with acute severe asthma Country: New Zealand coughing, FET, vibration, wing Peak expiratory flow rate (L/min):* flapping, percussion, thoracic mobility Baseline measures comparable G1: 278 ± 87 Intervention setting: exercises, postural correction between groups: Yes G2: 298 ± 87 Pediatric hospital ward exercises) G1 vs. G2: p=NS 2 60-min treatments/day for 2 days + Age, years (mean ± SD): Study Design: nebulized salbutamol G1: 9.5 ± 2.7 Peak expiratory flow rate, %**: RCT G2: 10.0 ± 2.6 G1: 97 ± 16 Comparator: Placebo (psychological G2: 97 ± 29 / emotional support, 20 mins ) + Underlying condition, (mean ± SD): G1 vs. G2: p=NS nebulized salbutamol NA FVC , %: Groups/n: Mechanical ventilation: G1: 95 ± 19 G1: CPT/19 NR G2: 100 ± 18 G2: Placebo/19 G1 vs. G2: p=NS

Followup: Immediately after 4th Functional residual capacity, %: treatment G1: 126 ± 17 G2: 132 ± 23 % available at follow-up: G1 vs. G2: p=NS G1: 84.2 G2: 94.7 Residual volume,%: G1: 159 ± 43 G2: 169 ± 53 G1 vs. G2: p=NS

Total lung capacity, %: G1: 121 ± 13 G2: 115 ± 16 G1 vs. G2: p=NS

Maximum mid-expiratory flow (FEF25-75), %: G1: 67 ± 22 G2: 59 ± 26 G1 vs. G2: p=NS

FEV1, %: G1: 87 ± 18 G2: 86 ± 21 G1 vs. G2: p=NS Length of stay (LOS)-hospital: G2 > G1 p=NS (data not clearly reported) *At hospital discharge; **After 4th treatment/placebo No statistical difference in lung function among the most severe patients (n=7/group) between treatment groups

Appendix-147

F. Abbreviations and Acronyms

AARC American Association of Respiratory Care ACBT Active Cycle of Breathing Technique APACHE Acute Physiology and Chronic Health Evaluation ASA American Association of Anesthesiologists CABG Coronary Artery Bypass Grafting CER Comparative Effectiveness Review CI Confidence Interval CINAHL Cumulative Index of Nursing and Allied Health Literature COPD Chronic Obstructive Pulmonary Disease CPAP Continuous Positive Airway Pressure CPT Chest Physical Therapy/Physiotherapy ED Emergency Department EPC Evidence-Based Practice Center EQ-5D European Quality of Life-Five Dimensions EQ-VAS European Quality of Life-Visual Analog Scales FET Forced Expiratory Technique

FEV1 Forced Expiratory Volume in 1 second FVC Forced Vital Capacity G Group HFCWC High Frequency Chest Wall Compression HR Heart Rate ICU Intensive Care Unit IPV Intrapulmonary Percussion Ventilation ITT Intention to treat KQ Key Question LOS Length of Stay (in hospital) MATREX Management of Exacerbations of COPD n Number NPPV Noninvasive Positive Pressure Ventilation NR Not reported NS Not significant

Appendix-148

PEF Peak expiratory flow PEP Positive Expiratory Pressure PICO Population, intervention, comparator(s), outcomes QOL Quality of Life RCT Randomized Controlled Trial SGRQ St. George’s Respiratory Quality Questionnaire SMI Sustained Maximal Inspiration VAP Ventilator acquired pneumonia

Appendix-149

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