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Bulletin L'académie Nationale De Médecine Tome 202 — Mai et Juin — N os 5-6 2018 BULLETIN DE L’ACADÉMIE NATIONALE DE MÉDECINE publié par MM. Daniel C, Secrétaire perpétuel et Jean François A , Secrétaire adjoint Rédacteur en chef : Professeur Jean-Noël F Adjointe à la Rédaction : Sibylle du C ACADÉMIE NATIONALE DE MÉDECINE 16, RUE BONAPARTE — 75272 PARIS CEDEX 06 http://www.academie-medecine.fr 2018 — Tome 202 — Mai-Juin — N os 5-6 Sommaire BULLETIN DE L’ACADÉMIE NATIONALE DE MÉDECINE publié par MM. Daniel C, Secrétaire perpétuel et Jean François A , Secrétaire adjoint Rédacteur en chef : Professeur Jean-Noël F Adjointe à la Rédaction : Sibylle du C sommaire Rapports 817 Rapport 18-03. Efficacité et effets indésirables des statines : évidences et polémiques Efficacy and side effects of statin therapy: a reappraisal Michel Komajda, au nom de la Commission IV (Maladies cardiovasculaires) 837 Rapport 18-04. La place de la France dans les essais cliniques à promotion industrielle Yvon Lebranchu (Rapporteur), Au nom d’un groupe de travail rattaché à la Commission II (Thérapeutique-Pharmacologie-Toxicologie-Médicaments et autres produits de santé) 859 Rapport 18-05. La biologie médicale face aux défis de l’évolution des besoins de santé Medical biology in the face of the evolution of health care needs Claude Dreux, François-Xavier Maquart (rapporteurs), au nom du groupe de travail inter-académique de l’Académie nationale de médecine et de l’Aca- démie nationale de Pharmacie. 873 Rapport 18-06. La demande d’une nouvelle orientation (rhumatologie) par l’établissement thermal de Vals-les-Bains Daniel Bontoux et Christian Roques 811 Académie nationale de Médecine Communiqué 883 À propos de la dépénalisation de la consommation de cannabis Jean-Pierre. Goullé, Jean Costentin, Claude-Pierre Giudicelli, Jean-Pierre Olié au nom de la commission V (Santé Mentale-Neurosciences-Addictions) Séance dédiée : « Les complications cardiovasculaires du diabète » Communications 887 Le risque cardiovasculaire du diabétique : les évidences Cardiovascular risk of the diabetic patient ; which evidence? Fabrice Bonnet 897 Le contrôle glycémique réduit-il les complications cardiovasculaires du dia- bète de type 2 ? Does blood glucose control prevent macrovascular complications of type 2 diabetes? Bernard Charbonnel 909 Diabète et insuffisance cardiaque : données épidémiologiques et implications thérapeutiques. Diabetes mellitus and heart failure: epidemiology and therapeutic implica- tions. Michel Komajda Séance dédiée : « Le myélome » Éditorial 919 Myélome multiple : introduction Multiple Myeloma : introduction Jean-Louis Michaux Communications 923 Biologie du myélome multiple : utilité clinique Multiple myeloma biology: clinical utility Hervé Avet-Loiseau 935 De la radiographie standard à l’IRM corps entier : 30 ans de progrès en imagerie du myélome multiple From the radiographic skeletal survey to whole body MRI : 30 year- advances in imaging of multiple myeloma Frédéric Lecouvet, Bruno Vandeberg, Jacques Malghem, Baudouin Mal- dagie, Augustin Ferrant et Jean-Louis Michaux 953 Guérison du myélome multiple : un objectif envisageable à court terme ? Is curing myeloma feasible in the near future? Thierry Facon 963 Présentation de l’Association Française des Malades du Myélome Multiple (AF3M) Bernard Delcour 812 Sommaire Séance dédiée : « Les coûts des médicaments des cancers » 975 Éditorial Jacques Rouëssé Communications 977 Modalités et déterminants de la fixation des prix des médicaments des cancers en France Prices of cancer drugs in France: pricing system and determining factors Gilles Bouvenot 989 Le coût des anti-cancéreux : un défi pour les systèmes de santé des pays de l’OCDE Cost of anticancer drugs: a challenge for health systems of OCDE countries Valérie Paris 1003 Enjeux et difficultés de la gestion des médicaments onéreux non intégrés dans la liste en sus pour un hôpital traitant des cancers Jean-Yves Blay, David Perol, Thomas Bachelot, Philippe Zrounba, Pierre Meeus, Sophie Beaupere, Bertrand Favier 1013 Prix et coûts des traitements anticancéreux : réalités, enjeux et perspectives Prices and costs of anticancer drugs: realities, issues and perspectives Éric Baseilhac, Caroline Heng, Damien Dorizon 1025 Conclusion de la séance dédiée : « Les coûts des médicaments des cancers » Michel Huguier Séance délocalisée à Lille Communications 1027 Le fœtus et son environnement : rôle des professionnels pour préserver le capital santé des adultes de demain The first 1 000 days of life: Role of healthcare providers to preserve the health capital of tomorrow’s adults Laurent Storme, Sylvie Deghilage, Julia Tepel, Dominique Turck, Vincent Prevot, Michel Cosson, Frédéric Gottrand, Philippe Deruelle 1037 Quel est le poids des gènes dans l’obésité ? Obesity genes in obesity Philippe Froguel 1041 Oxygène et cicatrisation Oxygen and wound healing Daniel Mathieu 1049 Émergence de la simple surveillance du cancer de prostate et des traitements partiels. Rôle clé de l’IRM. Emergence of simple surveillance of prostate cancer and partial treat- ments. Key role of MRI. Prostate cancer: emergence of surveillance or partial therapy Arnauld Villers, Jonathan Olivier, Arthur Annoot, Philippe Puech, Xavier Leroy 813 Académie nationale de Médecine Séance des correspondants de la 2 e division : « Résultats à long terme des grandes prothèses articulaires des membres » 1059 Éditorial Jacques Caton, Patrice Papin Communications 1063 Les prothèses totales de hanche Total hip arthroplasties Philippe Hernigou 1071 Résultats à long terme des prothèses du genou. Long term results of Total Knee Arthroplasties. Sébastien Lustig, Cécile Batailler, Elvire Servien 1087 Les prothèses d’épaule : résultats à moyen et long terme Shoulder arthroplasties: mid and long term results Jean-François Kempf 1101 Surveillance radiologique des grandes prothèses des membres Radiological monitoring of the major joint prostheses Gérard Morvan, Henri Guerini, Valérie Vuillemin Séance dédiée : « Allergologie : une nouvelle spécialité pour lutter contre une épidémie liée à notre environnement » Communications 1117 Pollution de l’air et baisse de la biodiversité : quels enjeux pour le patient allergique ? Air pollution and biodiversity loss: what are the concerns for the allergic patient? Isabella Annesi-Maesano 1127 Nouveaux phénotypes et endotypes des maladies allergiques respiratoires New phenotypes and endotypes of allergy-related respiratory conditions Jocelyne Just 1139 Allergologie aujourd’hui. Un livre blanc pour enseignement et pratiques Allergology today. A white paper for teaching and practising Pascal Demoly, en partenariat avec la FFAL Communications 1147 DocaMED : Application numérique d’enseignement et de documentation sur les médicaments et leurs indications thérapeutiques DocaMED: Numeric application for teaching and documentation on medicines and their therapeutic indications Philippe Lechat, Sophie Ravoire 814 Sommaire 1159 Syndrome catatonique de l’enfant et de l’adolescent: une pathologie rare fréquemment associée à une cause organique Catatonic syndrome in child and adolescent: a rare condition with fre- quent underlying organic condition David Cohen, Marie Raffin, Xavier Benarou, Vladimir Ferrafiat, Angèle Consoli 1179 Place des substituts de l’os dans les pertes de substances osseuses What bone substitutes for what bone loss Didier Mainard, Patrick Netter Information 1201 Experts, expertises, et liens d’intérêt en médecine Experts, expertises, and conflict of interest Michel Huguier, Jean-Paul Tillement, Didier Houssin, Gérard Milhaud, au nom de la commission VIII (Dépenses de santé, assurance maladie). Conférence invitée 1211 Bilan et perspectives de la réforme de l’État dans le secteur de la santé (1996-2018) Frédéric Salat-Baroux Chroniques historiques 1221 Robert Debré (1882-1978) une vocation française Patrice Debré 1229 Les grands Académiciens lillois The great academicians of Lille, France Jean-Louis Wémeau, Gilles Crépin, Gérard Dubois, Jean-Pierre Triboulet, Francis Wattel Éloge 1259 Éloge de M. Christian Cabrol (1925-2017) Iradj Gandjbakhch Vie de l’Académie 1265 Présentations d’ouvrages Oxford Textbook of Geriatric Medicine par Jean-Pierre Michel, B. Lynn Beattie, Finbarr C. Martin, Jeremy D. Walston. Editions Oxford Univer- sity Press, 3 e edition, 2017. Présentation par André Vacheron 1267 Santé : explosion programmée. Il faut agir maintenant ! par Patrick Bouet. Éditions de l’Observatoire 2018. Présentation par Jean Dubousset 815 Académie nationale de Médecine 1271 La médecine thermale ¢ Données scientifiques par Patrice Queneau et Christian Roques. Éditions John Libbey Eurotext 2018. Présentation par Daniel Bontoux 1275 L’Homme glial : une révolution dans les sciences du cerveau par Yves Agid et Pierre Magistretti. Éditions Odile Jacob, 2018. Présentation par Emmanuel Alain Cabanis 1282 Jacques Rouëssé. Le Bien-Aimé se meurt. Louis XV, le malade et ses médecins. Éditions Fiacre, 2018. Présentation par Pierre Bégué 1287 Actes Recommandations aux auteurs 1307 Instructions Abonnements au Bulletin de l’Académie nationale de médecine 000 Tarifs et modalités 816 Bull. Acad. Natle Méd., 2018, 202, n os 5-6, 817-835, séance du 22 mai 2018 RAPPORT 18-03 Un rapport exprime une prise de position officielle de l’Académie. L’Académie, saisie dans sa séance du mardi 22 mai 2018, a adopté le texte de ce rapport avec 43 voix pour, 14 voix contre et 19 abstentions . Efficacité et effets indésirables des statines : évidences et polémiques MOTS CLÉS : S TATINES. P RÉVENTION. R ISQUE CARDIO-VASCULAIRE. E FFETS INDÉSIRABLES . EFFICACITÉ
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