Lupus and Dermatitis

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QUICK GUIDE Lupus and Dermatitis Lupus Foundation of America, Indiana Chapter 9302 N Meridian St, Indianapolis, IN 46260 I (317) 225-4400 Facts & Statistics About Treatment Skin conditions comprise 4 of the 11 criteria used by the American College of Steroid ointments Rheumatology for classifying lupus. Corticosteroids (e.g., prednisone) Mission Antimalarials (e.g., Plaquenil) Approximately one-third of all people with Anti-malarials The Lupus Foundation of America, lupus experience a condition called Immunosuppressants: Indiana Chapter is part of a national Raynaud’s phenomenon in which the Mycophenolate mofetil, force devoted to solving the cruel blood vessels supplying the fingers and azathioprine, methotrexate mystery of lupus while providing toes constrict. Thalidomide: Another long-term caring support to those who suffer About 10% of all people with lupus will option for cutaneous lupus- from its brutal impact. experience hives (urticaria) decrease the severity of the immune response. Symptoms of Lupus Physical therapy Immunomodulators Efforts Dermatitis Support research and conduct Malar rash education programs so everyone Photosensitivity affected by lupus can have an Livedo reticularis improved quality of life and get Alopecia answers and health professionals Oral and nasal ulcers know about new means to diagnose Hives and manage the disease. Purpura- discoloration under skin Cutaneous Vasculitis Conduct activities to increase Raynaud’s Phenomenon awareness of lupus, rally public support for those who are affected by lupus, and advocate on their behalf. If you have lupus "With passion and dermatitis, you should… perseverance, we will About Lupus Dermatitis Find healthy ways to cope. fulfill our purpose as Lupus is a chronic autoimmune Lifestyle changes disease that can damage any part an organization. That Limiting sun exposure through of the body. Most people with lupus use of sunscreens and sun- purpose is to be a experience some sort of skin protective clothing. resource for and involvement during their disease. Understand and process your Three forms of specific skin disease support to lupus emotions. occur in people with lupus: Chronic Engage a positive self-talk. patients, and to Cutaneous Lupus Erythematosus (CCLE) / Discoid Lupus Avoid sunbathing, tanning salons, ultimately live in a Erythematosus (DLE), Subacute travel to regions near the world without lupus." Cutaneous Lupus Erythematosus equator, outdoor jobs, and light (SCLE), and Acute Cutaneous Lupus bulbs with high UV irradiance - La Toija Snodgrass, CEO Erythematosus (ACLE). .

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Seborrheic Dermatitis: an Overview ROBERT A
Seborrheic Dermatitis: An Overview ROBERT A. SCHWARTZ, M.D., M.P.H., CHRISTOPHER A. JANUSZ, M.D., and CAMILA K. JANNIGER, M.D. University of Medicine and Dentistry at New Jersey-New Jersey Medical School, Newark, New Jersey Seborrheic dermatitis affects the scalp, central face, and anterior chest. In adolescents and adults, it often presents as scalp scaling (dandruff). Seborrheic dermatitis also may cause mild to marked erythema of the nasolabial fold, often with scaling. Stress can cause flare-ups. The scales are greasy, not dry, as commonly thought. An uncommon generalized form in infants may be linked to immunodeficiencies. Topical therapy primarily consists of antifungal agents and low-potency steroids. New topical calcineurin inhibitors (immunomodulators) sometimes are administered. (Am Fam Physician 2006;74:125-30. Copyright © 2006 American Academy of Family Physicians.) eborrheic dermatitis can affect patients levels, fungal infections, nutritional deficits, from infancy to old age.1-3 The con- neurogenic factors) are associated with the dition most commonly occurs in condition. The possible hormonal link may infants within the first three months explain why the condition appears in infancy, S of life and in adults at 30 to 60 years of age. In disappears spontaneously, then reappears adolescents and adults, it usually presents as more prominently after puberty. A more scalp scaling (dandruff) or as mild to marked causal link seems to exist between seborrheic erythema of the nasolabial fold during times dermatitis and the proliferation of Malassezia of stress or sleep deprivation. The latter type species (e.g., Malassezia furfur, Malassezia tends to affect men more often than women ovalis) found in normal dimorphic human and often is precipitated by emotional stress.
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Pompholyx Factsheet Pompholyx Eczema (Also Known As Dyshidrotic Eczema/Dermatitis) Is a Type of Eczema That Usually Affects the Hands and Feet
12 Pompholyx factsheet Pompholyx eczema (also known as dyshidrotic eczema/dermatitis) is a type of eczema that usually affects the hands and feet. In most cases, pompholyx eczema involves the development of intensely itchy, watery blisters, mostly affecting the sides of the fingers, the palms of the hands and soles of the feet. Some people have pompholyx eczema on their hands and/or feet with other types of eczema elsewhere on the body. This condition can occur at any age but is usually seen in adults under 40, and is more common in women. The skin is initially very itchy with a burning sensation of heat and prickling in the palms and/or soles. Then comes a sudden crop of small blisters (vesicles), which turn into bigger weepy blisters, which can become infected, causing redness, pain, swelling and pustules. There is often subsequent peeling as the skin dries out, and then the skin can become red and dry with painful cracks (skin fissures). Pompholyx eczema can also affect the nail folds and skin around the nails, causing swelling (paronychia). What causes it? A reaction could be the result of contact with potential irritants such as soap, detergents, solvents, acids/alkalis, The exact causes of pompholyx eczema are not known, chemicals and soil, causing irritant contact dermatitis. Or although it is thought that factors such as stress, there could be an allergic reaction to a substance that is sensitivity to metal compounds (such as nickel, cobalt or not commonly regarded as an irritant, such as rubber or chromate), heat and sweating can aggravate this nickel, causing allergic contact dermatitis.
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Skin Manifestation of SARS-Cov-2: the Italian Experience
Journal of Clinical Medicine Article Skin Manifestation of SARS-CoV-2: The Italian Experience Gerardo Cazzato 1 , Caterina Foti 2, Anna Colagrande 1, Antonietta Cimmino 1, Sara Scarcella 1, Gerolamo Cicco 1, Sara Sablone 3, Francesca Arezzo 4, Paolo Romita 2, Teresa Lettini 1 , Leonardo Resta 1 and Giuseppe Ingravallo 1,* 1 Section of Pathology, University of Bari ‘Aldo Moro’, 70121 Bari, Italy; [email protected] (G.C.); [email protected] (A.C.); [email protected] (A.C.); [email protected] (S.S.); [email protected] (G.C.); [email protected] (T.L.); [email protected] (L.R.) 2 Section of Dermatology and Venereology, University of Bari ‘Aldo Moro’, 70121 Bari, Italy; [email protected] (C.F.); [email protected] (P.R.) 3 Section of Forensic Medicine, University of Bari ‘Aldo Moro’, 70121 Bari, Italy; [email protected] 4 Section of Gynecologic and Obstetrics Clinic, University of Bari ‘Aldo Moro’, 70121 Bari, Italy; [email protected] * Correspondence: [email protected] Abstract: At the end of December 2019, a new coronavirus denominated Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was identified in Wuhan, Hubei province, China. Less than three months later, the World Health Organization (WHO) declared coronavirus disease-19 (COVID-19) to be a global pandemic. Growing numbers of clinical, histopathological, and molecular findings were subsequently reported, among which a particular interest in skin manifestations during the course of the disease was evinced. Today, about one year after the development of the first major infectious foci in Italy, various large case series of patients with COVID-19-related skin Citation: Cazzato, G.; Foti, C.; manifestations have focused on skin specimens.
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Shingles (Herpes Zoster) Hives (Urticaria) Psoriasis
Shingles (Herpes Zoster) Shingles starts with burning, tingling, or very sensitive skin. A rash of raised dots develops into painful blisters that last about two weeks. Shingles often occurs on the trunk and buttocks, but can appear anywhere. Most people recover, but pain, numbness, and itching linger for many -- and may last for months, years, or the rest of their lives. Treatment with antiviral drugs, steroids, antidepressants, and topical agents can help. Hives (Urticaria) A common allergic reaction that looks like welts, hives are often itchy, and sometimes stinging or burning. Hives vary in size and may join together to form larger areas. They may appear anywhere and last minutes or days. Medications, foods, food additives, temperature extremes, and infections like strep throat are some causes of hives. Antihistamines can provide relief. Psoriasis A non-contagious rash of thick red plaques covered with white or silvery scales, psoriasis usually affects the scalp, elbows, knees, and lower back. The rash can heal and recur throughout life. The cause of psoriasis is unknown, but the immune system triggers new skin cells to develop too quickly. Treatments include medications applied to the skin, light therapy, and medications taken by mouth, injection or infusion. Eczema Eczema describes several non-contagious conditions where skin is inflamed, red, dry, and itchy. Stress, irritants (like soaps), allergens, and climate can trigger flare-ups though they're not eczema's exact cause, which is unknown. In adults, eczema often occurs on the elbows and hands, and in "bending" areas, such as inside the elbows. Treatments include topical or oral medications and shots.
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BETA Betamethasone Valerate Cream 0.1% W/W Betamethasone Valerate Ointment 0.1% W/W
NEW ZEALAND CONSUMER MEDICINE INFORMATION BETA Betamethasone valerate cream 0.1% w/w Betamethasone valerate ointment 0.1% w/w discoid lupus Some of the symptoms of an What is in this leaflet erythematosus (recurring allergic reaction may include: scaly rash) shortness of breath; wheezing or This leaflet answers some common prickly heat skin reaction difficulty breathing; swelling of the questions about BETA Cream and insect bite reactions face, lips, tongue or other parts of Ointment. prurigo nodularis (an itching the body; rash, itching or hives on and thickening of the skin the skin. It does not contain all the available with lumps or nodules) information. It does not take the contact sensitivity reactions Do not use BETA Cream or place of talking to your doctor or an additional treatment for Ointment to treat any of the pharmacist. an intense widespread following skin problems as it reddening and inflammation could make them worse: All medicines have risks and of the skin, infected skin (unless the benefits. Your doctor has weighed when milder topical corticosteroids infection is being treated the risks of you using BETA Cream cannot treat the skin condition with an anti-infective or Ointment against the benefits effectively. medicine at the same time) they expect it will have for you. acne BETA Cream is usually used to rosacea (a facial skin If you have any concerns about treat skin conditions on moist condition where the nose, taking this medicine, ask your surfaces; BETA Ointment is usually cheeks, chin, forehead or doctor or pharmacist. used to treat skin conditions on dry, entire face are unusually scaly skin.
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Atopic Dermatitis 101 for Adults
TRIGGER TRACKER Atopic Dermatitis 101 for Adults WHAT IS ATOPIC DERMATITIS? IS THERE A CURE? Atopic dermatitis (AD) is the most common type There is no cure for of eczema. It often appears as a red, itchy rash or atopic dermatitis yet, dry, scaly patches on the skin. AD usually begins but there are treatments in infancy or childhood but can develop at any available and more are on the way. point in a person’s lifetime. It commonly shows up on the face, inside of the elbows or behind the WHAT ARE MY TREATMENT OPTIONS? knees, but it can appear anywhere on the body. It is important to have a regular schedule with AD care that includes bathing with a gentle IS IT CONTAGIOUS ? cleanser and moisturizing to lock water into the You can’t catch atopic dermatitis or spread it to skin and repair the skin barrier. Moisturized skin others. helps control flares by combating dryness and keeping out irritants and allergens. WHAT CAUSED IT? Depending on severity of symptoms and age, AD While the exact cause is unknown, researchers do treatments include lifestyle changes, over-the- know that people develop atopic dermatitis counter (OTC) and natural remedies, prescription because of a combination of genes and a trigger. topical medications, which are applied to the People with AD tend to have an over-reactive immune system that when triggered by skin; biologics, given by injection; something outside or inside the body, responds immunosuppressants, usually taken by mouth in by producing inflammation. It is this inflammation the form of a pill; and phototherapy, a form of that causes red, itchy and painful skin symptoms.
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Erythema Annulare Centrifugum ▪ Erythema Gyratum Repens ▪ Exfoliative Erythroderma Urticaria ▪ COMMON: 15% All Americans
Cutaneous Signs of Internal Malignancy Ted Rosen, MD Professor of Dermatology Baylor College of Medicine Disclosure/Conflict of Interest ▪ No relevant disclosures ▪ No conflicts of interest Objectives ▪ Recognize common disorders associated with internal malignancy ▪ Manage cutaneous disorders in the context of associated internal malignancy ▪ Differentiate cutaneous signs of leukemia and lymphoma ▪ Understand spidemiology of cutaneous metastases Cutaneous Signs of Internal Malignancy ▪ General physical examination ▪ Pallor (anemia) ▪ Jaundice (hepatic or cholestatic disease) ▪ Fixed erythema or flushing (carcinoid) ▪ Alopecia (diffuse metastatic disease) ▪ Itching (excoriations) Anemia: Conjunctival pallor and Pale skin Jaundice 1-12% of hepatocellular, biliary tree or pancreatic cancer PRESENT with jaundice, but up to 40-60% eventually develop it World J Gastroenterol 2003;9:385-91 For comparison CAN YOU TELL JAUNDICE FROM NORMAL SKIN? JAUNDICE Alopecia Neoplastica Most common report w/ breast CA Lung, cervix, desmoplastic mm Hair loss w/ underlying induration Biopsy = dermis effaced by tumor Ann Dermatol 26:624, 2014 South Med J 102:385, 2009 Int J Dermatol 46:188, 2007 Acta Derm Venereol 87:93, 2007 J Eur Acad Derm Venereol 18:708, 2004 Gastric Adenocarcinoma: Alopecia Ann Dermatol 2014; 26: 624–627 Pruritus: Excoriation ▪ Overall risk internal malignancy presenting as itch LOW. OR =1.14 ▪ CTCL, Hodgkin’s & NHL, Polycythemia vera ▪ Biliary tree carcinoma Eur J Pain 20:19-23, 2016 Br J Dermatol 171:839-46, 2014 J Am Acad Dermatol 70:651-8, 2014 Non-specific (Paraneoplastic) Specific (Metastatic Disease) Paraneoplastic Signs “Curth’s Postulates” ▪ Concurrent onset (temporal proximity) ▪ Parallel course ▪ Uniform site or type of neoplasm ▪ Statistical association ▪ Genetic linkage (syndromal) Curth HO.
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Drug Eruptions.Pdf
Drug eruptions & reactions What are drug eruptions? Drug reactions are unwanted and unexpected reactions occurring in the skin (and sometimes other organ systems) that may result from taking a medication for the prevention, diagnosis or treatment of a medical problem. They may appear after the correct use of the medication or drug. It may also appear due to overdose (wrong dose is taken), following accumulation of drugs in the body over time, or by interactions with other medications being taken or used by the person. Drug eruptions could be caused by an allergy or hypersensitivity to the drug, by a direct toxic effect of the drug or medication on the skin, or by other mechanisms. Drug eruptions vary in severity – from a minor nuisance to a more severe problem – and may even cause death. Drug eruptions occur in up to 15% of courses of drug prescribed by medical or natural therapy practitioners. What causes drug eruptions? Drug eruptions are caused by medications which are prescribed by your doctor, purchased over-the- counter or purchased as compounded herbal/naturopathic medicines. Drugs taken orally, injected, delivered by patch application, rubbed onto the skin (e.g. creams, ointments and lotions) can all cause reactions. The potential to develop an adverse reaction to a drug is influenced by the age, gender and genetic makeup of the person; the nature of the condition being treated; and the possible interactions with other medications being taken. Some classes of drugs are known to cause drug eruptions more commonly than others. What do drug eruptions look like in the skin? The appearance of drug eruptions varies depending on the mechanism of the drug reaction.
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Allergic Contact Dermatitis Handout
#30: ALLERGIC CONTACT DERMATITIS PATIENT PERSPECTIVES Allergic contact dermatitis Contact dermatitis is an itchy rash that is caused by something touching (contacting) your skin. The rash is usually red, bumpy, and itchy. Sometimes there are blisters filled with fluid. THERE ARE TWO TYPES OF CONTACT DERMATITIS: COMMON FORMS OF ALLERGIC CONTACT DERMATITIS: 1. Some things that contact skin are very irritating and will cause a rash in most people. This rash is called irritant contact dermatitis. Examples are acids, soaps, cold weather, and friction. » ALLERGIC CONTACT DERMATITIS TO HOMEMADE SLIME 2. Some things that touch your skin give you a rash because you are allergic to them. This rash is called allergic contact dermatitis. » Slime is a homemade gooey These are items that do not bother everyone’s skin. They only substance that many young people cause a rash in people who are allergic to those items. make and play with. » There are several recipes for making WHAT ARE COMMON CAUSES OF ALLERGIC slime. Common ingredients include CONTACT DERMATITIS IN CHILDREN AND boric acid, contact lens solution, WHERE ARE THEY FOUND? laundry detergent, shaving cream, and school glue. Many ingredients » Homemade slime: often irritation (irritant contact dermatitis) being used can cause irritation results from soap or detergent but can have allergic contact (“irritant contact dermatitis”) and some dermatitis to glues and other ingredients can cause allergic contact dermatitis. » Plants: poison ivy, poison oak, poison sumac » Children playing with slime may get » Metals (especially nickel): snaps, jewelry, an itchy rash on their hands. There belt buckles, electronics, toys can be blisters, flaking, peeling, and cracking.
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Drug Eruptions
DRUG ERUPTIONS http://www.aocd.org A drug eruption is an adverse skin reaction to a drug. Many medications can cause reactions, especially antimicrobial agents, sulfa drugs, NSAIDs, chemotherapy agents, anticonvulsants, and psychotropic drugs. Drug eruptions can imitate a variety of other skin conditions and therefore should be considered in any patient taking medications or that has changed medications. The onset of drug eruptions is usually within 2 weeks of beginning a new drug or within days if it is due to re-exposure to a certain drug. Itching is the most common symptom. Drug eruptions occur in approximately 2-5% of hospitalized patients and in greater than 1% of the outpatient population. Adverse reactions to drugs are more prevalent in women, in the elderly, and in immunocompromised patients. Drug eruptions may be immunologically or non-immunologically mediated. There are 4 types of immunologically mediated reactions, with Type IV being the most common. Type I is immunoglobulin-E dependent and can result in anaphylaxis, angioedema, and urticaria. Type II is cytotoxic and can result in purpura. Type III reactions are immune complex reactions which can result in vasculitis and type IV is a delayed-type reaction which results in contact dermatitis and photoallergic reactions. This is important as different medications are associated with different types of reactions. For example, insulin is related with type I reactions whereas penicillin, cephalosporins, and sulfonamides cause type II reactions. Quinines and salicylates can cause type III reactions and topical medications such as neomycin can cause type IV reactions. The most common drugs that may potentially cause drug eruptions include amoxicillin, trimethoprim sulfamethoxazole, ampicillin, penicillin, cephalosporins, quinidine and gentamicin sulfate.
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PE2342 Seborrheic Dermatitis
Seborrheic Dermatitis What is seborrheic Seborrheic dermatitis is a common skin condition. It causes redness, dermatitis? scaling, or flaky patches in infants, teens and adults. What parts of the • Scalp (this is known as dandruff, or cradle cap in infants) body are usually • Eyebrows affected? • Eyelids • Ears • Nose • Skin fold areas (such as armpits or thighs) What causes The cause of seborrheic dermatitis is not known. Some believe that it is seborrheic caused by an overgrowth of yeast. It is not related to what you eat and it is dermatitis? not contagious. Stress and sickness often make seborrheic dermatitis symptoms worse, but they do not cause it. Symptoms can get better or worse for no reason. What are the Symptoms include: symptoms of • Redness seborrheic • Itching dermatitis? • Scaly patches on your skin that may look greasy or oily • Scales or flakes on the head or in the hair • Crusty yellow flakes on the eyelids or eyelashes What are the There is no cure for seborrheic dermatitis, but there are ways to keep it treatment options? under control. Treatment options for seborrheic dermatitis depend on what part of the body is showing symptoms. Skin Seborrheic dermatitis of the skin can usually be controlled by putting on steroid or antifungal creams to the skin (topical). These medicines help with the redness and itching of your child’s skin. Check with your child’s healthcare provider before giving your child any type of topical medicine. They will help you determine which treatment option would be best. 1 of 2 To Learn More Free Interpreter Services • Dermatology • In the hospital, ask your nurse.
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Understanding Eczema / Atopic Dermatitis
Understanding Atopic Dermatitis An educational health series from National Jewish Health If you would like further information about National Jewish Health, please write to: National Jewish Health 1400 Jackson Street Denver, Colorado 80206 or visit: njhealth.org Understanding Atopic Dermatitis An educational health series from National Jewish Health IN THIS ISSUE About Atopic Dermatitis 2 What Causes Atopic Dermatitis? 3 Do You Have Atopic Dermatitis? 3 Should You Go to an Expert? 4 What Are Your Goals? 4 Avoiding Things that Make Itching and Rash Worse 5 Treatment and Medication Therapy 9 Soak and Seal 9 What Medicines Will Help? 10 Action Plan for Atopic Dermatitis 13 What to Do When Symptoms Are Severe 14 Living with Atopic Dermatitis 15 Remember Your Goals 15 Glossary 16 Note: This information is provided to you as an educational service of National Jewish Health. It is not meant as a substitute for your own doctor. © Copyright 2018, National Jewish Health About Atopic Dermatitis Atopic dermatitis is a common chronic skin disease. It is also called atopic eczema. Atopic is a term used to describe allergic conditions such as asthma and hay fever. Both dermatitis and eczema mean inflammation of the skin. People with atopic dermatitis tend to have dry, itchy and easily irritated skin. They may have times when their skin is clear and other times when they have rash. INFANTS AND SMALL CHILDREN In infants and small children, the rash is often present on face, as well as skin around the knees and elbows. TEENAGERS AND ADULTS In teenagers and adults, the rash is often present in the creases of the wrists, elbows, knees or ankles, and on the face or neck.
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