Expression of Genes Related to Anti-Inflammatory Pathways Are Modified Among Farmers’ Children
CORE Metadata, citation and similar papers at core.ac.uk Provided by edoc Expression of Genes Related to Anti-Inflammatory Pathways Are Modified Among Farmers’ Children Remo Frei1,2*., Caroline Roduit2,3., Christian Bieli3, Susanne Loeliger2,3, Marco Waser4,5, Annika Scheynius6, Marianne van Hage7,Go¨ ran Pershagen8, Gert Doekes9, Josef Riedler10, Erika von Mutius11, Felix Sennhauser3, Cezmi A. Akdis1,2, Charlotte Braun-Fahrla¨nder4,5, Roger P. Lauener2,12,as part of the PARSIFAL study team" 1 Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland, 2 Christine Ku¨hne-Center for Allergy Research and Education, Zurich, Switzerland, 3 Children’s Hospital, University of Zurich, Zurich, Switzerland, 4 Swiss Tropical and Public Health Institute, Basel, Switzerland, 5 University of Basel, Basel, Switzerland, 6 Translational Immunology Unit, Department of Medicine Solna, Karolinska Institute and University Hospital, Stockholm, Sweden, 7 Clinical Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institute and University Hospital, Stockholm, Sweden, 8 Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, 9 Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands, 10 Children’s Hospital Schwarzach, Schwarzach, Austria, 11 Dr. von Hauner Children’s Hospital, Ludwig Maximilians University Munich, Munich, Germany, 12 Kantonsspital St.Gallen, St.Gallen, Switzerland Abstract Background: The hygiene hypothesis states that children exposed to higher loads of microbes such as farmers’ children suffer less from allergies later in life. Several immunological mechanisms underpinning the hygiene hypothesis have been proposed such as a shift in T helper cell balance, T regulatory cell activity, or immune regulatory mechanisms induced by the innate immunity.
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