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184 Integration of the transcriptional regulation of carbon sources, in Escherichial coli K‐12, with their central metabolism and other cellular systems Peralta‐Gil M., Ledezma‐Tejeida D., Gama‐Castro S., Santos‐Zavaleta A. and Collado‐Vides J. UNAM, Mexico

Presenter: Daniela Ledezma‐Tejeida

RegulonDB is a database that integrates mainly the biological knowledge of the mechanisms that regulate transcription initiation in Escherichia coli and, eventually, the knowledge on its complete regulatory network. Thus, we have followed different strategies in order to better describe the complexity of the biology within the database, such as curating by publication date, on the bases of regulons and sigmulons, by functional class, by biological system, by binding sites of a particular transcription factor (TF), including other regulatory mechanisms, and finally by elementary genetic sensory response unit, or Gensor unit (GU). In this sense, to attain an understanding of bacterial metabolic adaptations to carbon source availability, currently we have curated about 40 regulons related to carbon source utilization, and we have diagrammed 15 GUs involved in the uptake and degradation of different carbon sources. Our main goal of this specific integration is to facilitate understanding of E. coli metabolic adaptations to carbon source availability and the coupling between the different genetic regulatory layers within the central metabolism. We are integrating and modeling the information on the metabolic pathways for the different carbon sources with the available information at the molecular level, including the interplay between transcriptional regulation and regulatory mechanisms, such as allosteric interactions and the effects of secondary products. Thus, these interactions at the molecular level lead to adjustments in metabolism between glycolytic and gluconeogenic carbon sources and the efficient adaptation between the electron transport chain, different two‐component systems, and the acid stress response, among other cellular systems. The unified view of transport, metabolism and gene regulation help to better understand both metabolism and the regulation adaptation to alternative carbon sources encoded in the genome of E.coli K‐12.