DOCSLIB.ORG

Anaerobe 2016, the 13Th Biennial Congress of the Anaerobe 2016 NASHVILLE Nashville, TN, USA Society of the Americas (ASA)

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Anaerobe 2016, the 13Th Biennial Congress of the Anaerobe 2016 NASHVILLE Nashville, TN, USA Society of the Americas (ASA) PROGRAM & ABSTRACT BOOK 2016 NASHVILLE ANAEROBE JULY 11-14, 2016 2016 NASHVILLE ANAEROBE JULY 11-14, 2016 The 13th Biennial Congress of the Anaerobe Society of the Americas Sheraton Nashville Downtown Hotel Nashville, Tennessee PROGRAM & ABSTRACT BOOK 2016 NASHVILLE ANAEROBE JULY 11-14, 2016 CONTENTS Course Directors ii Welcome Letter iii 2016About the SocietiesNASHVILLE iv Patrons JULY 11-14,v 2016 ANAEROBEExhibitors v Keynote Speaker vi Lifetime Achievement Award vii Accreditation viii Curricular Goals & Objectives viii Presenters & Faculty ix Disclosure Information xii Congress Program xv Abstract Table of Contents 1 Abstracts 3 Poster Index 237 Author Index 249 The 13th Biennial Congress of the Anaerobe Society of the Americas Sheraton Nashville Downtown Hotel • Nashville, Tennessee 2016 NASHVILLE 2016 NASHVILLE ANAEROBE JULY 11-14, 2016 Welcome Letter ANAEROBE JULY 11-14, 2016 COURSE DIRECTOR David M. Aronoff, M.D. ASA President Vanderbilt University Medical Center Welcome to ANAEROBE 2016, the 13th biennial Congress of the Anaerobe 2016 NASHVILLE Nashville, TN, USA Society of the Americas (ASA). This forum brings2016 together cliniciansNASHVILLE and Y 11-14, 2016 Y 11-14, 2016 ANAEROBE JUL scientists from around the world to engage in presentations,ANAEROBE dialogues,JUL and ORGANIZING COMMITTEE interactions related to the clinical and microbiological aspects of anaerobic Emma Allen-Vercoe, Ph.D. Brandi Limbago, Ph.D. bacteriology. The Congress will explore the role of anaerobes in both health University of Guelph Centers for Disease Control and disease, while addressing both traditional and emerging technologies Guelph, Canada Atlanta, GA USA for identification and diagnosis. Karen Carroll, M.D. Leandro Araujo Lobo, Ph.D. ANAEROBE 2016 again illustrates the international interest in the field of Johns Hopkins University Federal University of Rio de Janeiro Baltimore, MD USA Rio de Janeiro, Brazil anaerobic bacteriology. 187 abstracts were submitted for presentation, representing the work of 624 scientists from more than 38 countries. Ramyavardhanee Chandrasekaran Jeanne Marrazzo, M.D., M.P.H. Vanderbilt University ASA Vice President The Keynote Address will be given by Dr. Curtis J. Donskey of Case Western Nashville, TN USA University of Alabama Reserve University and the Louis Stokes Cleveland VA Medical Center. Birmingham, AL USA Diane M. Citron Dr. Donskey will challenge traditional models of Clostridium difficile R.M. Alden Research Lab Andrew B. Onderdonk, Ph.D. transmission and present new approaches to infection control. Culver City, CA USA Harvard University Boston, MA USA The Lifetime Achievement Award will be presented to Dr. Bennett Lorber Laura M. Cox, Ph.D. of Temple University. Dr. Lorber is being recognized for his career Harvard University Elisabeth Nagy, M.D., Ph.D. Boston, MA USA University of Szeged contributions to the fields on anaerobic bacteriology and infectious diseases. David Fredericks, M.D. Szeged, Hungary We would like to thank the members of the Organizing Committee and ASA Secretary Carl Erik Nord, M.D. the Session Chairs for their assistance in formulating what promises to University of Washington Karolinska Institute be another exciting program. We also would like to thank those from Seattle, WA USA Stockholm, Sweden industry—both patrons and exhibitors listed on page v—for the financial Dale N. Gerding, M.D. Cynthia L. Sears, M.D. support that makes this Congress possible, as well as grants from the ASA Past President ASA Past President National Institutes of Health, the European Society of Clinical Microbiology Hines VA Hospital Johns Hopkins University and Infectious Diseases, Burroughs Welcome Fund, and the Gut Check Maywood, IL USA Baltimore, MD USA Foundation. Ellie J.C. Goldstein, M.D. Casey J. Theriot, Ph.D. ASA Treasurer, Past President North Carolina State University In addition, we are grateful for our continued relationship with Anaerobe R.M. Alden Research Lab / UCLA Raleigh, NC Systems for helping organize the Pre-Congress Workshop, Microbiology Santa Monica, CA USA Educational Services for providing the continuing education accreditation Glenn S. Tillotson, Ph.D. Yiping Han, Ph.D. for laboratory scientists, and to our Anaerobe journal for sponsorship of the Cempra Pharmaceuticals Columbia University Chapel Hill, NC USA Young Investigator’s Competition. New York, NY USA Very special thanks goes to Dr. Ronald and Pamela Goldman, who again Purnima Kumar, D.D.S. Vincent Young, M.D. Ohio State University University of Michigan have done an exemplary job in bringing this meeting together. Ann Arbor, MI USA Columbus, OH USA Lastly, I hope you have an opportunity to explore Nashville, while you are Ronald J. Goldman, Ph.D. here, and savor what makes it the Music Capital of America. ASA Executive Director Los Angeles, CA USA Our hope is that ANAEROBE 2016 serves to foster stimulating discussions, as well as cultivate personal relationships that continue to invigorate the entire ANAEROBE SOCIETY OF THE AMERICAS field beyond the timeframe of this Congress. PO Box 452058, Los Angeles, CA 90045 USA Phone: 310-216-9265 Fax: 310-216-9274 Web: www.anaerobe.org E-mail: [email protected] David M. Aronoff ASA President ©2016 Anaerobe Society of the Americas iv v 2016 NASHVILLE 2016 NASHVILLE ANAEROBE JULY 11-14, 2016 About the Society Patrons & Exhibitors ANAEROBE JULY 11-14, 2016 ABOUT THE ANAEROBE SOCIETY Anaerobe Society of the Americas gratefully acknowledges the following Founded2016 in 1992, theNASHVILLE Anaerobe Society of the Americas, a non-profit foundation, organizations for their generous support of this congress.2016 NASHVILLE ANAEROBE JULY 11-14, 2016 ANAEROBE JULY 11-14, 2016 serves as a forum for those interested in anaerobes, anaerobic infections, and Support for this activity was received in the form of educational grants from: related matters. The Society aims: (1) to stimulate interest in anaerobes and to encourage interchange among anaerobists from all disciplines, including u Burroughs Wellcome Fund medical, dental, veterinary, environmental, and basic sciences; (2) to bring u European Society of Clinical Microbiology and Infectious Diseases together investigators, clinicians, and laboratory scientists interested in u Gut Check Foundation anaerobic infections for formal and informal meetings; (3) to review and assess u National Institute of Health new advances in the field; (4) to discuss areas of controversy; and (5) to mark future directions. Support for this activity from commercial interests include: There are four levels of membership: Doctoral, Non-Doctoral, Verified Student, PLATINUM PATRONS and Retired. Details and application form are available on our web site: www. u Merck anaerobe.org. u Sanofi Pasteur ANAEROBE SOCIETY PRESIDENTS SILVER PATRONS This is the 13th biennial Anaerobe Society Congress. u Pfizer Past Anaerobe Society sponsored programs were: BRONZE PATRONS ANAEROBE 2014 —Chicago, IL USA u Actelion Pharmaceuticals ANAEROBE 2012 —San Francisco, CA USA u Anaerobe Journal / Elsevier u ANAEROBE 2010 —Philadelphia, PA USA Anaerobe Systems u ProViotic ANAEROBE 2008 —Long Beach, CA USA u Rebiotix ANAEROBE 2006 —Boise, ID USA u Seres Therapeutics u Summit Therapeutics ANAEROBE 2004 —Annapolis, MD USA u TechLab ANAEROBE OLYMPIAD 2002 —Park City, UT USA EXHIBITORS 2001: AN ANAEROBE ODYSSEY —Los Angeles, CA USA u Advanced Instruments u Key Scientific Products u u ANAEROBE 2000 —Manchester, England Bio K+ International List Biological Laboratories u bioMérieux u Microbiology International ANAEROBE 1998 —Buenas Aires, Argentina u Bruker Daltonic u Shel Lab ANAEROBE 1996 —Chicago, IL USA u Cepheid u Synthetic Biologics u Coy Laboratory Products u VWR ANAEROBE 1994 —Los Angeles, CA ANAEROBE 1992 —Los Angeles, CA vi vii 2016 NASHVILLE Lifetime 2016 NASHVILLE ANAEROBE JULY 11-14, 2016 Keynote Speaker Achievement Award ANAEROBE JULY 11-14, 2016 CURTIS J. DONSKEY, M.D. BENNETT LORBER, M.D. 2016 NASHVILLE Dr. Lorber studied zoology and art history at 2016 NASHVILLE ANAEROBE JULY 11-14, 2016 ANAEROBE JULY 11-14, 2016 Dr. Donskey is Professor of Medicine at Case Swarthmore College. He received his M.D. degree Western Reserve University. He graduated from the University of Pennsylvania School of from medical school at the Medical College Medicine and completed a residency in internal of Wisconsin in Milwaukee. He completed medicine and a fellowship in infectious diseases at his medical residency and chief residency at Temple University Hospital, following which he Brown University, followed by a fellowship was appointed to the Temple University School of in Infectious Diseases at Case Western Medicine faculty. In 1988, he was named the first Reserve University. recipient of the Thomas M. Durant Chair in Medicine at Temple. He is also a Professor of Microbiology He has been serving as the Hospital and Immunology and served as Chief of the Section Epidemiologist and Chair of the Infection of Infectious Diseases from 1983-2006. Control Committee at the Louis Stokes Cleveland VA Medical Center since 1999. His interest in anaerobic infections emerged during his infectious diseases fel- lowship. He was responsible for a number of early studies regarding the role of His research focuses primarily on infection control of healthcare-associated anaerobic bacteria and their treatment in human respiratory, intra-abdominal, and pathogens, including Clostridium difficile, methicillin-resistant Staphylococcus gynecological infections. Other scholarly interests include human listeriosis,
Load more

Recommended publications
  • Comparative Genomics of the Genus Porphyromonas Identifies Adaptations for Heme Synthesis Within the Prevalent Canine Oral Species Porphyromonas Cangingivalis
    GBE Comparative Genomics of the Genus Porphyromonas Identifies Adaptations for Heme Synthesis within the Prevalent Canine Oral Species Porphyromonas cangingivalis Ciaran O’Flynn1,*, Oliver Deusch1, Aaron E. Darling2, Jonathan A. Eisen3,4,5, Corrin Wallis1,IanJ.Davis1,and Stephen J. Harris1 1 The WALTHAM Centre for Pet Nutrition, Waltham-on-the-Wolds, United Kingdom Downloaded from 2The ithree Institute, University of Technology Sydney, Ultimo, New South Wales, Australia 3Department of Evolution and Ecology, University of California, Davis 4Department of Medical Microbiology and Immunology, University of California, Davis 5UC Davis Genome Center, University of California, Davis http://gbe.oxfordjournals.org/ *Corresponding author: E-mail: ciaran.ofl[email protected]. Accepted: November 6, 2015 Abstract Porphyromonads play an important role in human periodontal disease and recently have been shown to be highly prevalent in canine mouths. Porphyromonas cangingivalis is the most prevalent canine oral bacterial species in both plaque from healthy gingiva and at University of Technology, Sydney on January 17, 2016 plaque from dogs with early periodontitis. The ability of P. cangingivalis to flourish in the different environmental conditions char- acterized by these two states suggests a degree of metabolic flexibility. To characterize the genes responsible for this, the genomes of 32 isolates (including 18 newly sequenced and assembled) from 18 Porphyromonad species from dogs, humans, and other mammals were compared. Phylogenetic trees inferred using core genes largely matched previous findings; however, comparative genomic analysis identified several genes and pathways relating to heme synthesis that were present in P. cangingivalis but not in other Porphyromonads. Porphyromonas cangingivalis has a complete protoporphyrin IX synthesis pathway potentially allowing it to syn- thesize its own heme unlike pathogenic Porphyromonads such as Porphyromonas gingivalis that acquire heme predominantly from blood.
    [Show full text]
  • The Salivary Microbiome Is Consistent Between Subjects
    www.nature.com/scientificreports OPEN The salivary microbiome is consistent between subjects and resistant to impacts of short-term Received: 19 April 2017 Accepted: 24 August 2017 hospitalization Published: xx xx xxxx Damien J. Cabral1, Jenna I. Wurster1, Myrto E. Flokas2, Michail Alevizakos2, Michelle Zabat1, Benjamin J. Korry1, Aislinn D. Rowan1, William H. Sano1, Nikolaos Andreatos2, R. Bobby Ducharme3, Philip A. Chan3, Eleftherios Mylonakis2, Beth Burgwyn Fuchs2 & Peter Belenky1 In recent years, a growing amount of research has begun to focus on the oral microbiome due to its links with health and systemic disease. The oral microbiome has numerous advantages that make it particularly useful for clinical studies, including non-invasive collection, temporal stability, and lower complexity relative to other niches, such as the gut. Despite recent discoveries made in this area, it is unknown how the oral microbiome responds to short-term hospitalization. Previous studies have demonstrated that the gut microbiome is extremely sensitive to short-term hospitalization and that these changes are associated with signifcant morbidity and mortality. Here, we present a comprehensive pipeline for reliable bedside collection, sequencing, and analysis of the human salivary microbiome. We also develop a novel oral-specifc mock community for pipeline validation. Using our methodology, we analyzed the salivary microbiomes of patients before and during hospitalization or azithromycin treatment to profle impacts on this community. Our fndings indicate that azithromycin alters the diversity and taxonomic composition of the salivary microbiome; however, we also found that short-term hospitalization does not impact the richness or structure of this community, suggesting that the oral cavity may be less susceptible to dysbiosis during short-term hospitalization.
    [Show full text]
  • Thi Na Utaliblat in Un Minune Talk
    THI NA UTALIBLATUS010064900B2 IN UN MINUNE TALK (12 ) United States Patent ( 10 ) Patent No. : US 10 , 064 ,900 B2 Von Maltzahn et al . ( 45 ) Date of Patent: * Sep . 4 , 2018 ( 54 ) METHODS OF POPULATING A (51 ) Int. CI. GASTROINTESTINAL TRACT A61K 35 / 741 (2015 . 01 ) A61K 9 / 00 ( 2006 .01 ) (71 ) Applicant: Seres Therapeutics, Inc. , Cambridge , (Continued ) MA (US ) (52 ) U . S . CI. CPC .. A61K 35 / 741 ( 2013 .01 ) ; A61K 9 /0053 ( 72 ) Inventors : Geoffrey Von Maltzahn , Boston , MA ( 2013. 01 ); A61K 9 /48 ( 2013 . 01 ) ; (US ) ; Matthew R . Henn , Somerville , (Continued ) MA (US ) ; David N . Cook , Brooklyn , (58 ) Field of Classification Search NY (US ) ; David Arthur Berry , None Brookline, MA (US ) ; Noubar B . See application file for complete search history . Afeyan , Lexington , MA (US ) ; Brian Goodman , Boston , MA (US ) ; ( 56 ) References Cited Mary - Jane Lombardo McKenzie , Arlington , MA (US ); Marin Vulic , U . S . PATENT DOCUMENTS Boston , MA (US ) 3 ,009 ,864 A 11/ 1961 Gordon - Aldterton et al. 3 ,228 ,838 A 1 / 1966 Rinfret (73 ) Assignee : Seres Therapeutics , Inc ., Cambridge , ( Continued ) MA (US ) FOREIGN PATENT DOCUMENTS ( * ) Notice : Subject to any disclaimer , the term of this patent is extended or adjusted under 35 CN 102131928 A 7 /2011 EA 006847 B1 4 / 2006 U .S . C . 154 (b ) by 0 days. (Continued ) This patent is subject to a terminal dis claimer. OTHER PUBLICATIONS ( 21) Appl . No. : 14 / 765 , 810 Aas, J ., Gessert, C . E ., and Bakken , J. S . ( 2003) . Recurrent Clostridium difficile colitis : case series involving 18 patients treated ( 22 ) PCT Filed : Feb . 4 , 2014 with donor stool administered via a nasogastric tube .
    [Show full text]
  • Bacterial Diversity of Symptomatic Primary Endodontic Infection by Clonal Analysis
    ORIGINAL RESEARCH Endodontic Therapy Bacterial diversity of symptomatic primary endodontic infection by clonal analysis Abstract: The aim of this study was to explore the bacterial diversity of 10 root canals with acute apical abscess using clonal analysis. Letícia Maria Menezes NÓBREGA(a) Francisco MONTAGNER(b) Samples were collected from 10 patients and submitted to bacterial Adriana Costa RIBEIRO(c) DNA isolation, 16S rRNA gene amplification, cloning, and sequencing. (c) Márcia Alves Pinto MAYER A bacterial genomic library was constructed and bacterial diversity Brenda Paula Figueiredo de Almeida GOMES(a) was estimated. The mean number of taxa per canal was 15, ranging from 11 to 21. A total of 689 clones were analyzed and 76 phylotypes identified, of which 47 (61.84%) were different species and 29 (38.15%) (a) Universidade Estadual de Campinas were taxa reported as yet-uncultivable or as yet-uncharacterized (UNICAMP), Piracicaba Dental School, Endodontics Division, Piracicaba, SP, Brazil. species. Prevotella spp., Fusobacterium nucleatum, Filifactor alocis, and Peptostreptococcus stomatis were the most frequently detected species, (b) Universidade Federal do Rio Grande do Sul (UFRGS), Department of Conservative followed by Dialister invisus, Phocaeicola abscessus, the uncharacterized Dentistry, Porto Alegre, RS, Brazil. Lachnospiraceae oral clone, Porphyromonas spp., and Parvimonas micra. (c) Universidade de São Paulo (USP), Institute Eight phyla were detected and the most frequently identified taxa of Biomedical Science, Department of Oral belonged to the phylum Firmicutes (43.5%), followed by Bacteroidetes Microbiology, São Paulo, SP, Brazil. (22.5%) and Proteobacteria (13.2%). No species was detected in all studied samples and some species were identified in only one case.
    [Show full text]
  • Protease Activities of Vaginal Porphyromonas Species Disrupt Coagulation and Extracellular Matrix in the Cervicovaginal Niche
    bioRxiv preprint doi: https://doi.org/10.1101/2021.07.07.447795; this version posted July 7, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. 1 Protease activities of vaginal Porphyromonas species disrupt coagulation and 2 extracellular matrix in the cervicovaginal niche 3 4 5 Karen V. Lithgow1, Vienna C.H. Buchholz1*, Emily Ku1, Shaelen Konschuh1, Ana D’Aubeterre1†, and Laura 6 K. Sycuro1,2,3,4,# 7 8 9 1Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, AB, 10 Canada 11 2Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB, Canada 12 3Alberta Children’s Hospital Research Institute, University of Calgary, Calgary, AB, Canada 13 4International Microbiome Centre, University of Calgary, Calgary, AB, Canada 14 15 16 #Corresponding author: Laura Sycuro, [email protected] 17 *Present affiliation: 18 Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, Canada 19 †Present affiliation: 20 Department of Biological Sciences, University of Alberta, Edmonton, AB, Canada 21 22 Running Title: Protease activity of vaginal Porphyromonas species 23 24 Abstract: 240 words 25 Importance: 141 words 26 Main Text: 7540 words bioRxiv preprint doi: https://doi.org/10.1101/2021.07.07.447795; this version posted July 7, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. 27 Abstract 28 Porphyromonas asaccahrolytica and Porphyromonas uenonis are frequently isolated from the human 29 vagina and are linked to bacterial vaginosis and preterm labour.
    [Show full text]
  • Porphyromonas Spp. Have an Extensive
    Porphyromonas spp. have an extensive host range in ill and healthy individuals and an unexpected environmental distribution: A systematic review and meta-analysis Luis Acuña-Amador, Frédérique Barloy-Hubler To cite this version: Luis Acuña-Amador, Frédérique Barloy-Hubler. Porphyromonas spp. have an extensive host range in ill and healthy individuals and an unexpected environmental distribution: A systematic review and meta-analysis. Anaerobe, Elsevier Masson, 2020, 66, pp.102280. 10.1016/j.anaerobe.2020.102280. hal-02974793 HAL Id: hal-02974793 https://hal.archives-ouvertes.fr/hal-02974793 Submitted on 16 Nov 2020 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. 1 Porphyromonas spp. have an extensive host range in ill and healthy individuals and an 2 unexpected environmental distribution: a systematic review and meta-analysis. 3 4 Luis Acuña-Amadora,* and Frédérique Barloy-Hublerb 5 6 aLaboratorio de Investigación en Bacteriología Anaerobia, Centro de Investigación en 7 Enfermedades Tropicales, Facultad de Microbiología, Universidad de Costa Rica, San José, 8 Costa Rica 9 bInstitut de Génétique et Développement de Rennes, IGDR-CNRS, UMR6290, Université de 10 Rennes 1, Rennes, France 11 * [email protected], +506 2511-8616 1 12 ABSTRACT 13 Studies on the anaerobic bacteria Porphyromonas, mainly focused on P.
    [Show full text]
  • 79493C7788c18ce2e14c5a36e8
    GBE Comparative Genomics of the Genus Porphyromonas Identifies Adaptations for Heme Synthesis within the Prevalent Canine Oral Species Porphyromonas cangingivalis Ciaran O’Flynn1,*, Oliver Deusch1, Aaron E. Darling2, Jonathan A. Eisen3,4,5, Corrin Wallis1,IanJ.Davis1,and Stephen J. Harris1 1The WALTHAM Centre for Pet Nutrition, Waltham-on-the-Wolds, United Kingdom 2The ithree Institute, University of Technology Sydney, Ultimo, New South Wales, Australia 3Department of Evolution and Ecology, University of California, Davis 4Department of Medical Microbiology and Immunology, University of California, Davis 5UC Davis Genome Center, University of California, Davis *Corresponding author: E-mail: ciaran.ofl[email protected]. Accepted: November 6, 2015 Abstract Porphyromonads play an important role in human periodontal disease and recently have been shown to be highly prevalent in canine mouths. Porphyromonas cangingivalis is the most prevalent canine oral bacterial species in both plaque from healthy gingiva and plaque from dogs with early periodontitis. The ability of P. cangingivalis to flourish in the different environmental conditions char- acterized by these two states suggests a degree of metabolic flexibility. To characterize the genes responsible for this, the genomes of 32 isolates (including 18 newly sequenced and assembled) from 18 Porphyromonad species from dogs, humans, and other mammals were compared. Phylogenetic trees inferred using core genes largely matched previous findings; however, comparative genomic analysis identified several genes and pathways relating to heme synthesis that were present in P. cangingivalis but not in other Porphyromonads. Porphyromonas cangingivalis has a complete protoporphyrin IX synthesis pathway potentially allowing it to syn- thesize its own heme unlike pathogenic Porphyromonads such as Porphyromonas gingivalis that acquire heme predominantly from blood.
    [Show full text]
  • WO 2014/121304 Al 7 August 2014 (07.08.2014) P O P C T
    (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2014/121304 Al 7 August 2014 (07.08.2014) P O P C T (51) International Patent Classification: 1A, Cambridge, MA 02142 (US). GOODMAN, Brian; c/o C12N 1/00 (2006.01) Seres Health, Inc., 161 First Street, Suite 1A, Cambridge, MA 02 142 (US). (21) International Application Number: PCT/US2014/014747 (74) Agents: HUBL, Susan T. et al; Fenwick & West LLP, Silicon Valley Center, 801 California Street, Mountain (22) International Filing Date: View, CA 94041 (US). 4 February 2014 (04.02.2014) (81) Designated States (unless otherwise indicated, for every English (25) Filing Language: kind of national protection available): AE, AG, AL, AM, (26) Publication Language: English AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, (30) Priority Data: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, 61/760,574 4 February 2013 (04.02.2013) US HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, 61/760,585 4 February 2013 (04.02.2013) US KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, 61/760,606 4 February 2013 (04.02.2013) us MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, 61/760,584 4 February 2013 (04.02.2013) us OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, 61/798,606 15 March 2013 (15.03.2013) us SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, 61/926,918 13 January 2014 (13.01.2014) us TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, (71) Applicant: SERES HEALTH, INC.
    [Show full text]
  • PPAD, Porphyromonas Gingivalis and the Subgingival Microbiome in Periodontitis and Autoantibody-Positive Individuals at Risk Of
    PPAD, Porphyromonas gingivalis and the Subgingival Microbiome in Periodontitis and Autoantibody-positive Individuals at Risk of Rheumatoid Arthritis Zijian Cheng Submitted in accordance with the requirements for the degree of Doctor of Philosophy The University of Leeds School of Dentistry September, 2018 The candidate confirms that the work submitted is his own and that appropriate credit has been given where reference has been made to the work of others. - ii - Acknowledgements It is a pleasure to thank a number of people who have supported me through my PhD study. This thesis could not have been completed without their support. Firstly, I would like to express my sincere gratitude and appreciation to my supervisors, Dr. Thuy Do, Dr. Josephine Meade, Prof. Paul Emery and Prof. Deirdre Devine for their valuable guidance, support and encouragement throughout my study. I am grateful to my colleagues and all staff in the Division of Oral Biology who are friendly and supportive, for making an enjoyable environment during this study period. Special thanks are extended to Shabnum Rashid from Oral Microbiology group and David Sharples from Faculty of Biological Science for the training and help with my lab work. Additionally, my appreciation is extended to Prof. Phil Marsh for his valuable help and suggestions. This research has been carried out by a team and I would like to thank all the clinicians, nurses and technicians from School of Dentistry, Leeds Dental Institute and Leeds Musculoskeletal Biomedical Research Unit, who have contributed to this project. I also wish to extend my special appreciation to the volunteers and patients who participated in this study.
    [Show full text]
  • Supplementary Table 1. Descriptive Data Dataset 1 Dataset 2 PD
    Supplementary Table 1. Descriptive Data Dataset 1 Dataset 2 PD Control P PD Control P Enrolled with complete data 212 136 - 323 184 - Number of Passed sequence QC* 201 132 - 323 184 - subjects Passed sequence and metadata QC* 199 132 - 323 184 - Number of unique ASVs detected 4,863 3,315 - 9,188 6,667 - Microbiome Number of genera detected 404 333 - 527 441 - 1 Stool sample travel time in days, mean (SD) 3.3 (1.9) 2.6 (1.5) 2E-03 5.2 (3.3) 5.0 (2.6) ns 2 Age, mean (SD) 68.3 ( 9.2) 70.2 (8.6) 0.04 67.7 (9.0) 66.4 (8.3) 0.05 Age & Sex 3 Sex (male) 67% 39% 1E-06 64% 30% 2E-13 Seattle, WA 93 58 - 0 0 - Albany, NY 75 62 - 0 0 - 4 Geography Atlanta, GA 31 12 - 0 0 - Birmingham, AL 0 0 - 323 184 - 5 Race (%White) 99% 100% ns 99% >99% ns Ancestry 6 Jewish - - - 7% 7% ns 7 BMI, mean (SD) 26.6 (5.5) 28.3 (5.7) 0.02 27.4 (5.0) 27.9 (5.9) ns 8 Weight Lost >10 pounds in past year 23% 12% 0.01 25% 12% 3E-04 9 Gained >10 pounds in past year 13% 8% ns 15% 11% ns 10 Fruits or vegetables 78% 89% 0.02 - - - 11 Meat, fish, poultry 57% 63% ns - - - 12 Nuts 22% 28% ns - - - 13 Yogurt 36% 45% ns - - - Daily Diet 14 Grains 69% 67% ns - - - 15 Alcohol 60% 71% 0.04 42% 56% 3E-03 16 Tobacco 7% 4% ns 4% 7% ns 17 Caffeine 71% 76% ns 86% 88% ns 18 Constipation in ³3 days prior to stool collection 15% 2% 3E-05 18% 5% 2E-05 19 Diarrhea on the day of stool collection 3% 2% ns 4% 3% ns 20 GI pain on the day of stool collection 9% 7% ns 9% 2% 1E-03 21 Gas on the day of stool collection 14% 2% 9E-05 16% 4% 2E-04 22 Bloating on the day of stool collection 10% 2% 7E-03 12%
    [Show full text]
  • The Gut Microbiome, Aging, and Longevity: a Systematic Review
    nutrients Review The Gut Microbiome, Aging, and Longevity: A Systematic Review Varsha D. Badal 1,2, Eleonora D. Vaccariello 1, Emily R. Murray 1, Kasey E. Yu 1, Rob Knight 3,4,5,6, 1,2,6,7, 1,2,8, , Dilip V. Jeste y and Tanya T. Nguyen * y 1 Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA; [email protected] (V.D.B.); [email protected] (E.D.V.); [email protected] (E.R.M.); [email protected] (K.E.Y.); [email protected] (D.V.J.) 2 Sam and Rose Stein Institute for Research on Aging, University of California San Diego, La Jolla, CA 92093, USA 3 Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA; [email protected] 4 Department of Computer Science and Engineering, University of California San Diego, La Jolla, CA 92093, USA 5 Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA 6 Center for Microbiome Innovation, University of California San Diego, La Jolla, CA 92093, USA 7 Department of Neurosciences, University of California San Diego, La Jolla, CA, 92093, USA 8 VA San Diego Healthcare System, La Jolla, CA 92161, USA * Correspondence: [email protected] These authors contributed equally to this work. y Received: 19 November 2020; Accepted: 3 December 2020; Published: 7 December 2020 Abstract: Aging is determined by complex interactions among genetic and environmental factors. Increasing evidence suggests that the gut microbiome lies at the core of many age-associated changes, including immune system dysregulation and susceptibility to diseases.
    [Show full text]
  • Human Papillomavirus Infection and Cervical Intraepithelial Neoplasia
    Chen et al. BMC Infectious Diseases (2020) 20:629 https://doi.org/10.1186/s12879-020-05324-9 RESEARCH ARTICLE Open Access Human papillomavirus infection and cervical intraepithelial neoplasia progression are associated with increased vaginal microbiome diversity in a Chinese cohort Yulian Chen1,2,3†, Xingdi Qiu1,2,3†, Wenjing Wang1,2,3, Dong Li1,2,3, Anyue Wu1,2,3, Zubei Hong1,2,3, Wen Di1,2,3* and Lihua Qiu1,2,3* Abstract Background: In this study, the association between human papillomavirus (HPV) infection and related cervical intraepithelial neoplasia (CIN) or cervical cancer and vaginal microbiome was evaluated in Chinese cohorts. Methods: The vaginal bacterial composition of five groups, HPV-infected women without CINs (HPV, n =78),women with low-grade squamous intraepithelial lesions (LSIL, n = 51), women with high-grade squamous intraepithelial lesions (HSIL, n = 23), women with invasive cervical cancer (Cancer, n = 9) and healthy women without HPV infection (Normal, n = 68), was characterized by deep sequencing of barcoded 16S rRNA gene fragments (V3–4) using Illumina MiSeq. Results: HPV infection increased vaginal bacterial richness and diversity regardless of the status of CINs. The vaginal bacterial richness and diversity were further augmented in women with cervical cancer. Lactobacillus was the most abundant genus in all groups. HPV infection had a negative influence on the abundances of Lactobacillus, Gardnerella and Atopobium. Accordingly, HPV infection increased the relative abundance of Prevotella, Bacillus, Anaerococcus, Sneathia, Megasphaera, Streptococcus and Anaerococcus. The increased proportions of Bacillus, Anaerococcus and the reduced abundance of Gradnerella vaginalis were probably related with the progression of CINs severity.
    [Show full text]