Archive of SID Anesth Pain Med. 2019 April; 9(2):e87415. doi: 10.5812/aapm.87415. Published online 2019 April 27. Research Article Comparison of the Sedation Quality of Etomidate, Propofol, and Midazolam in Combination with Fentanyl During Phacoemulsification Cataract Surgery: A Double-Blind, Randomized, Controlled, Clinical Trial Leili Adinehmehr 1, Hamidreza Shetabi 1, *, Darioush Moradi Farsani 1, Ali Salehi 2 and Mohadese Noorbakhsh 3 1Anesthesiology and Critical Care Department, Isfahan University of Medical Sciences, Isfahan, Iran 2Ophthalmology Department, Isfahan University of Medical Sciences, Isfahan, Iran 3Isfahan University of Medical Sciences, Isfahan, Iran *Corresponding author: Anesthesiology Department, Al Zahra Medical Center, Isfahan University of Medical Sciences, Sofeh Blvd., Isfahan, Iran. Email:
[email protected] Received 2018 December 11; Revised 2019 March 23; Accepted 2019 March 28. Abstract Background: According to the favorable effects of combination therapy to provide better sedation during phacoemulsification and lack of any studies investigating the sedative effect of etomidate, propofol, and midazolam in combination with fentanyl during the procedure. Objectives: The current study aimed at comparing the sedative properties of the mentioned three combination therapies in this field. Methods: The current double-blind, randomized, controlled clinical trial was conducted on patients referred for elective pha- coemulsification surgery under sedation. They were randomly allocated to the three groups to receive fentanyl plus one of the following medications: Propofol, midazolam, and etomidate. Demographic characteristics, medical condition, and hemodynamic parameters before, during, and after surgery,sedation level, anesthetic complications, sedation-related adverse events, and patients’ and surgeons’ satisfaction were evaluated and recorded by the anesthesiologist and compared in the three studied groups.