Stanford-Duke

STANFORD-DUKE November 29-30, 2018 Li Ka Shing Conference Center Paul Berg Hall Stanford University SCHEDULE THURSDAY, NOVEMBER 29, 2018 INTRODUCTORY REMARKS 1:00 pm Welcome Joseph C. Wu, MD, PhD Director, Stanford Cardiovascular Institute Simon H. Stertzer, MD, Professor, and Professor of Medicine & Radiology Stanford University Howard Rockman, MD Edward S. Orgain Professor of Cardiology Professor of Medicine, Cell Biology, and Molecular Genetics Duke University Sean M. Wu, MD, PhD Associate Professor of Medicine and, by courtesy, Pediatrics Stanford University 1:05 pm Introduction Lloyd Minor, MD The Carl and Elizabeth Naumann Professorship for the Dean of the School of Medicine Professor of Otolaryngology - Head and Neck Surgery, and, by courtesy, of Neurobiology and Bioengineering Stanford University OPENING KEYNOTE 1:10 pm Heart & Brain Sciences, Health Equity and the AHA Ivor Benjamin, MD President, American Heart Association Director, Cardiovascular Center Professor, Department of Medicine, Division of Cardiology Medical College of Wisconsin SCHEDULE GOOGLE BASELINE PROJECT: A STANFORD DUKE COLLABORATION Session Chair: Francois Haddad, MD, Clinical Associate Professor, Cardiovascular Medicine, Stanford University 1:45 pm Project Baseline: Convergence of Data & Healthcare David Maron, MD Director of Preventive Cardiology Clinical Professor, Cardiovascular Medicine Stanford University 2:05 pm Project Baseline: Return of Results - Seek and Ye Shall Find Svati Shah, MD, MHS Vice-Chair of Translational Research Associate Professor of Medicine Duke University 2:25 pm Project Baseline: Participants as Partners - Engage, Educate, Empower Ken Mahaffey, MD Director of Stanford Center for Clinical Research Vice Chair Clinical Research, Department of Medicine Stanford University 2:45 pm Coffee Break G PROTEIN-COUPLED RECEPTOR BIOLOGY ACROSS THE CONTINENT Session Chair: Helen Blau, PhD, Donald E. and Delia B. Baxter Foundation Professor, Director, Baxter Laboratory for Stem Cell Biology, Stanford University 3:05 pm Ubiquitin-dependent regulation of ꞵ-adrenergic receptor trafficking and signaling Sudha Shenoy, PhD Associate Professor in Medicine and in Cell Biology Duke University 3:30 pm New Paradigms for Arrestin-Mediated Signaling at GPCRs and Other Receptors Sudar Rajagopal, MD, PhD Assistant Professor in Cardiology Co-Director of Duke Pulmonary Vascular Disease Center Duke University SCHEDULE 3:50 pm ꞵ-receptor Subtype Regulation of Cardiotoxicity/Cardioprotection: Just When You Thought it was Safe to go Back in the Water Daniel Bernstein, MD Alfred Woodley Salter and Mabel G. Salter Endowed Professor of Pediatrics Stanford University 4:10 pm Biased GPCR Signaling Howard Rockman, MD Edward S. Orgain Professor of Cardiology Professor of Medicine, Cell Biology, and Molecular Genetics Duke University 4:30 pm Conclusion of First Day and Departure FRIDAY, NOVEMBER 30, 2018 7:30 am Arrival and Breakfast 8:00 am Welcome Robert Harrington, MD Chair, Department of Medicine Arthur L. Bloomfield Professor of Medicine Stanford University KEYNOTE LECTURE Chair: Howard Rockman, MD, Edward S. Orgain Professor of Cardiology, Professor of Medicine, Cell Biology, and Molecular Genetics, Duke University 8:05 am Structure-aided Drug Discovery for G Protein Coupled Receptors Brian Kobilka, MD Professor of Molecular and Cellular Physiology 2012 Nobel Laureate Stanford University SCHEDULE BASIC & TRANSLATIONAL APPROACHES TO VASCULAR & MYOCARDIAL BIOLOGY Session Chair: Marlene Rabinovitch, MD, Dwight and Vera Dunlevie Professor in Pediatric Cardiology, Stanford University 8:50 am Genomic Approaches to Discover Novel Drug Targets for Obesity and Insulin Resistance Erik Ingelsson, MD, PhD Professor of Medicine Stanford University 9:10 am TREK-1 Affects the Cardiac Injury Response by Modulating Intercellular Crosstalk Dennis Abraham, MD Assistant Professor of Medicine Director of Duke Cardiovascular Physiology Core Duke University 9:30 am Coffee Break 9:40 am Genetic Mechanisms of Coronary Artery Disease: What Can we Learn From GWAS? Thomas Quertermous, MD William G. Irwin Professor in Cardiovascular Medicine Stanford University 10:00 am The Long and the Short of it: Telomere Length as a Hallmark of Cardiac Failure Helen Blau, PhD Donald E. and Delia B. Baxter Foundation Professor Director, Baxter Laboratory for Stem Cell Biology Stanford University 10:20 am Unfolding the Misfolded: Molecular Insights into Cardiac Amyloidosis Ronglih Liao, PhD Professor of Medicine Co-Director, Stanford Cardiac Amyloid Center Stanford University 10:40 am Coffee Break SCHEDULE HEART FAILURE THERAPIES- PERCUTANEOUS, SURGICAL, AND REGENERATIVE APPROACHES Chair: Sharon Hunt, MD, Professor Emerita of Medicine (Cardiolovascular), Stanford 10:50 am Innovative Therapies for Ischemic Cardiomyopathy Y. Joseph Woo, MD Norman E. Shumway Professor Chair, Department of Cardiothoracic Surgery Stanford University 11:10 am Man vs. Machine: Will Mechanically Assisted Circulation Achieve Its Goals? Joseph Rogers, MD Professor of Medicine Chief Medical Officer, Duke University 11:30 am Personalized Medicine in Heart Transplantation Kiran Khush, MD, MAS Associate Professor of Medicine Stanford University 11:50 am Vascular Approaches to Innate Heart Regeneration Ravi Karra, MD Assistant Professor of Medicine Duke University 12:10 pm Lunch and Poster Viewing / Meet the Professors Lunch GENOME, TRANSCRIPTOME, AND PRECISION HEALTH Chair: Nigam Shah, MBBS, PhD, Associate Professor of Medicine (Biomedical Informatics) and of Biomedical Data Science, Stanford University 1:10 pm Pharmacogenomics for Precision Cardiovascular Health Latha Palaniappan, MD, MS Professor of Medicine Stanford University 1:30 pm Unexpected Biology of snoRNAs in the Heart Chris Holley, MD, PhD Assistant Professor of Medicine and Molecular Genetics and Microbiology Duke University SCHEDULE 1:50 pm Population, Medical, and Functional Genomics in the Personal Genome Era Carlos Bustamante, PhD Professor of Biomedical Data Science, of Genetics and, by courtesy, of Biology Stanford University 2:10 pm Coffee Break STATE-OF-THE-ART APPROACHES TO THE DETECTION AND TREATMENT OF EP DISEASES Chair: Sanjiv Narayan, MSc, MD, Professor of Medicine (Cardiovascular Medicine), Stanford University 2:20 pm Wearables and Arrhythmias: Where are we Headed? Mintu Turakhia, MD, MAS Executive Director, Stanford Center for Digital Health Associate Professor of Medicine Palo Alto Veterans Affairs Health Care System 2:40 pm Innovation and the Future of Arrhythmia Therapy Paul Wang, MD Professor of Medicine Stanford University Editor of Circulation: Arrhythmia and Electrophysiology BEST ABSTRACT TRAINEE PRESENTATIONS Chair: Elan Burton, MD, Clinical Assistant Professor, Cardiothoracic Surgery, Stanford 3:00 pm Molecular Mechanisms of Angiotensin Receptor Activation and Biased Signaling Laura Wingler Duke University - Lefkowitz Lab 3:13 pm Parental Disease and Over-transmission of Genetic Risk for Diabetes are Related to Congenital Heart Disease in Offspring Catherine Tcheandjieu Stanford University - Priest Lab 3:26 pm On the Intertwined Nature of Endothelium and Muscle: Defining New Signaling Paradigms in Peripheral Artery Disease Hasan Abbas Duke University - Kontos Lab SCHEDULE 3:38 pm Modeling hypertrophic cardiomyopathy caused by mutations in beta-myosin using human induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs) Alison Schroer Stanford University - Bernstein Lab / Pruitt Lab (UCSB) 3:50 pm Coffee Break POPULATIONS, QUALITY, AND OUTCOMES IN CARDIOVASCULAR CARE Chair: Paul Heidenreich, MD, Professor of Medicine (Cardiovascular), and, by courtesy, of Health Research and Policy, Palo Alto Veterans Affairs Health Care System, Stanford 4:00 pm Evaluating Precision Medicine Mark Hlatky, MD Professor of Health Research and Policy and of Medicine Stanford University 4:20 pm Closing the Gaps in Care: What’s Next in Implementation Science? Eric Peterson, MD Fred Cobb Distinguished Professor of Medicine Duke University 4:40 pm Controversies in Economics of Precision Medicines Kevin Schulman, MD Professor of Medicine Associate Chair of Business Development and Strategy Stanford University 5:00 pm Wine and Cheese Reception and Poster Session with Presentation of Poster Awards KEYNOTE SPEAKERSCHEDULE BIOS Ivor Benjamin, MD Ivor Benjamin, MD, is the Director of the Cardiovascular Center (CVC) and a co-leader of the CVC program in Precision Cardiovascular Medicine at the Medical College of Wisconsin. He received his bachelor’s degree from Hunter College in New York and his MD from Johns Hopkins University School of Medicine. Dr. Benjamin is a certified specialist in internal medicine and cardiology. His research interests are in cardiology, inheritable heart failure, and myocardial infarctions, with a focus on the genes encoding heat shock proteins and oxido-reductive stress-response pathways and their relationship to genetic forms of heart disease, cardiotoxicological science, and precision medicine. Dr. Benjamin is an Established Investigator of the American Heart Association (AHA). He has received the AHA Award of Merit, the Daniel Savage Memorial Service Award from the Association of Black Cardiologists, and the NIH Director’s Pioneer Award from the National Heart, Lung, and Blood Institute. Dr. Benjamin serves as Editor-in-Chief of Cecil Essential Medicine 9th Edition. He is also the founding member of the Journal of the American Heart Association, and serves on the editorial boards of Circulation and Circulation Research. Brian Kobilka,

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