DOCSLIB.ORG

Table of Contents

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Table of Contents CONTENTS 1. Anatomy, Histology, and Embryology . 1 Nasal Cavity. 1 Anatomy. 1 Histology . 2 Embryology . 4 Paranasal Sinuses . 5 Anatomy. 5 Histology . 6 Oral Cavity . 6 Anatomy. 6 Histology . 6 Pharynx. 6 Anatomy. 6 Histology . 7 Larynx . 8 Anatomy. 8 Histology . 10 Embryology . 13 2. Staging of Head and Neck Carcinoma . 15 General Rules of Reporting. 15 Histopathologic Grade . 16 Specific Anatomic Sites. 16 Oral Cavity . 16 Pharynx. 17 Larynx . 18 Nasal Cavity and Paranasal Sinuses . 19 Stage Grouping . 20 3. Benign Squamous Proliferations . 21 Squamous Papilloma . 21 Schneiderian Papillomas . 22 Inverted Schneiderian Papilloma. 23 Exophytic Schneiderian Papilloma . 25 Oncocytic Schneiderian Papilloma . 29 Inverted Ductal Papilloma of Minor Salivary Glands. 30 Papillomas of the Larynx and Trachea. 33 Tumor-Like Lesions. 36 Verrucous Hyperplasia. 36 ix Tumors of the Upper Aerodigestive Tract and Ear Pseudoepitheliomatous Hyperplasia . 38 Verruca Vulgaris of the Larynx and Oral Cavity. 40 4. Conventional Squamous Cell Carcinoma. 47 Keratosis. 47 Dysplasia. 48 Grading Systems. 49 Invasive Squamous Cell Carcinoma. 53 Microscopic Findings. 53 Prognostic Indicators. 55 Cytologic Findings . 56 Molecular Findings. 58 Site-Specific Invasive Squamous Cell Carcinoma. 59 Lip . 59 Oral Cavity (General). 60 Oral Tongue . 62 Nasal Cavity/Paranasal Sinuses . 63 Nasopharynx . 65 Oropharynx. 66 Hypopharynx . 67 Larynx. 67 5. Squamous Cell Carcinoma: Diagnostically Problematic Variants . 81 Verrucous Carcinoma . 81 Spindle Cell Carcinoma. 87 Papillary Squamous Cell Carcinoma. 95 Adenosquamous Carcinoma. 98 Acantholytic (Adenoid and Angiosarcoma-Like) Squamous Cell Carcinoma . 103 Basaloid Squamous Cell Carcinoma. 107 Undifferentiated Carcinomas. 114 Epstein-Barr Virus-Associated Carcinoma . 114 Human Papillomavirus-Associated Carcinoma. 123 NUT Midline Carcinoma. 129 6. Glandular Neoplasms . 149 Adenocarcinoma (Nonsalivary Gland Types) . 149 Sinonasal Intestinal-Type Adenocarcinoma. 149 Low-Grade Nonintestinal Adenocarcinoma . 156 High-Grade Nonintestinal Adenocarcinoma . 160 Other Adenocarcinomas. 162 Respiratory Epithelial Adenomatoid (and Seromucinous) Hamartomas. 162 Sinonasal Ameloblastoma . 167 x Contents 7. Neural, Neuroendocrine, and Neuroectoderma Neoplasia. 173 Heterotopic Glial Tissue (Nasal Glioma) . 173 Ectopic Pituitary Tissue and Pituitary Adenoma. 176 Neurofibroma . 177 Neuromas. 181 Palisaded Encapsulated Neuroma (Solitary Circumscribed Neuroma) . 181 Traumatic Neuroma. 182 Mucosal Neuroma (Ganglioneuroma) . 182 Neurilemoma (Schwannoma) . 184 Neurothekeoma . 188 Melanotic Neuroectodermal Tumor of Infancy . 188 Granular Cell Tumor/Congenital Epulis . 191 Craniopharyngioma . 197 Meningioma . 198 Olfactory Neuroblastoma . 201 Sinonasal Undifferentiated Carcinoma. 212 Carcinoid Tumor and Moderately Differentiated Neuroendocrine Carcinoma (Atypical Carcinoid Tumor) . 219 Small Cell Carcinoma. 227 Malignant Melanoma. 232 Peripheral Neuroectodermal Tumor/Extraosseous Ewing Sarcoma . 240 8. Hematopoietic and Lymphoid Disorders. 261 Tonsillitis and Reactive Hyperplasia, Not Otherwise Specified. 263 Infectious Mononucleosis . 264 Hyperplasia of Waldeyer Ring in Human Immunodeficiency Virus Infection. 267 Sinus Histiocytosis with Massive Lymphadenopathy. 269 Mature B-Cell Neoplasms (Excluding Plasmacytoma). 272 Mature T- and NK-Cell Malignancies (Excluding NT-/T-Cell Lymphoma, Nasal Type) . 280 Extranodal NK-/T-Cell Lymphoma, Nasal Type . 283 Precursor Lymphoid Neoplasms. 291 Extraosseous Plasmacytoma . 292.
Load more

Recommended publications
  • Case Report Sialadenoma Papilliferum: Clinical Misdiagnosis with a Histological Decree
    Hindawi Publishing Corporation Case Reports in Dentistry Volume 2012, Article ID 356271, 4 pages doi:10.1155/2012/356271 Case Report Sialadenoma Papilliferum: Clinical Misdiagnosis with a Histological Decree A. Anuradha,1, 2 V. V. S. Ram Pr asad, 1 Bina Kashyap,1 and Vijay Srinivas1 1 Department of Oral Pathology, Saint Joseph Dental College and Hospital, Duggirala, Eluru, 534004, India 2 Anuradha ENT Hospital, Eluru Road, Gudivada, Krishna 521301, India Correspondence should be addressed to A. Anuradha, [email protected] Received 28 November 2011; Accepted 15 January 2012 Academic Editor: A. Epivatianos Copyright © 2012 A. Anuradha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Sialadenoma papilliferum is a rare salivary gland tumor clinically resembling papilloma originating probably from the excretory duct. It is characterized by a biphasic growth pattern of exophytic squamous component and endophytic glandular component. We report a rare case of sialadenoma papilliferum in the floor of the mouth with epithelial dysplasia with pertinent review of literature. The present case highlights the importance of keeping sialadenoma papilliferum as a differential diagnosis of exophytic papilliferous oral lesions and the need to explore the etiology and malignant potential of the tumor. 1. Introduction Clinically, the lesion was well circumscribed, white, and 1 cm diameter with a rough papilliferous surface. It was Sialadenoma papilliferum (SP) is a rare, distinctive benign provisionally diagnosed as papilloma and excision of the tumor of salivary gland classified under the ductal papillo- lesion was done under local anesthesia.
    [Show full text]
  • World Journal of Pharmaceutical Research Singh Et Al
    World Journal of Pharmaceutical Research Singh et al . World Journal of Pharmaceutical SJIF Impact Research Factor 7.523 Volume 6, Issue 10, 196-219. Review Article ISSN 2277– 7105 REACTIVE, INFECTIOUS AND BENIGN LESIONS OF SALIVARY GLAND- A REVIEW Dr. Rajeev Bhushan Singh*1, Dr. Rohit Jaiswal2, Dr. Aanchal Tandon3, Dr. Shafia Siddiqui4 1Post Graduate Student, Department of Oral Pathology and Microbiology, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, Uttar Pradesh, India. 2Professor and Head, Department of Oral Pathology and Microbiology, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, Uttar Pradesh, India. 3Senior Lecturer, Department of Oral Pathology and Microbiology, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, Uttar Pradesh, India. 4Reader, Department of Oral Pathology and Microbiology, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, Uttar Pradesh, India. ABSTRACT Article Received on 06 July 2017, Salivary gland tumors are relatively uncommon and account for Revised on 26 July 2017, approximately 3-6 percentage of all neoplasms of the head and neck. Accepted on 16 August 2017 DOI: 10.20959/wjpr201710-9269 Tumors of salivary glands usually occur in the major salivary glands (parotid, submandibular, sublingual), however, a small percentage occur in the minor salivary glands located within the oral mucosa, *Corresponding Author Dr. Rajeev Bhushan Singh palate, uvula, floor of the mouth, tongue, pharynx, larynx and Post Graduate Student, paranasal sinuses. The salivary glands are subject to a number of Department of Oral pathologic conditions. These include inflammatory infective diseases Pathology and such as viral, bacterial, or allergic sialadenitis, a variety of benign Microbiology, Sardar Patel tumors.
    [Show full text]
  • Classification of Salivary Gland Disorders
    Salivary Gland Diseases and Disorders Dr. Mahmoud E. Khalifa Prof of OMFS Lecture ILOs At the end of this chapter you should be able to: 1. Distinguish the clinical features of infections of the salivary glands from those in other structures 2. Differentiate on clinical grounds between infection, obstruction, benign and malignant neoplasms of the salivary glands 3. Plan and evaluate the results of the investigation of disorders of the salivary glands 4. List the important/relevant information to be elicited from patients with salivary gland disorders 5. Select cases which require referral for a specialist opinion 6. Describe the causes of a dry mouth and be able to distinguish between organic and functional causes. Anatomy Major glands Minor glands 3 pairs Situated mostly 800 to 1000 in the oral cavity Parotid Submandibular The majority atAlso found in the the junction of pharynx, larynx, the hard and soft trachea, and palates sinuses sublingual Functions These glands function to produce saliva, which serves as Lubricant for speech & swallowing Assists taste Immunologic (antibacterial) Digestive Cleansing properties Based on the type of secretion, the salivary glands may be grouped as: (i) Serous, (ii) Mucous and (iii) Mixed. Parotid gland secretion is serous in nature. The sublingual gland secretes mixed, but predominantly mucous. The submandibular gland secretion is also mixed, but is predominantly serous. The minor glands secrete mucous saliva. Parotid Gland The parotid gland is the largest salivary gland, the secretion of which is serous in nature. It is pyramidal in shape; The base located superficial and apex medially The base is triangular in shape its apex is towards the angle of the mandible, the base at the external acoustic meatus The parotid duct (Stenson‘s duct) Emerges at the anterior part of the gland.
    [Show full text]
  • (12) Patent Application Publication (10) Pub. No.: US 2006/0134109 A1 Gaitanaris Et Al
    US 2006O134109A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2006/0134109 A1 Gaitanaris et al. (43) Pub. Date: Jun. 22, 2006 (54) GPROTEIN COUPLED RECEPTORS AND in-part of application No. 60/461.329, filed on Apr. 9. USES THEREOF 2003. (75) Inventors: George A. Gaitanaris, Seattle, WA Publication Classification (US); John E. Bergmann, Mercer Island, WA (US); Alexander Gragerov, (51) Int. Cl. Seattle, WA (US); John Hohmann, La CI2O I/68 (2006.01) Conner, WA (US); Fusheng Li, Seattle, C7H 2L/04 (2006.01) WA (US); Linda Madisen, Seattle, WA (US); Kellie L. McIlwain, Renton, WA CI2P 2/06 (2006.01) (US); Maria N. Pavlova, Seattle, WA A 6LX 39/395 (2006.01) (US); Demitri Vassilatis, Seattle, WA C07K I4/705 (2006.01) (US); Hongkui Zeng, Shoreline, WA (52) U.S. Cl. ......................... 424/143.1: 435/6: 435/69.1; 435/320.1; 435/325; 530/350; (US) 536/23.5 Correspondence Address: SEED INTELLECTUAL PROPERTY LAW GROUP PLLC (57) ABSTRACT 701 FIFTHAVE SUTE 63OO The present invention provides GPCR polypeptides and SEATTLE, WA 98104-7092 (US) polynucleotides, recombinant materials, and transgenic (73) Assignee: Nura Inc., Seattle, WA (US) mice, as well as methods for their production. The polypep tides and polynucleotides are useful, for example, in meth (21) Appl. No.: 10/527,265 ods of diagnosis and treatment of diseases and disorders. The invention also provides methods for identifying com (22) PCT Fed: Sep. 9, 2003 pounds (e.g., agonists or antagonists) using the GPCR polypeptides and polynucleotides of the invention, and for (86) PCT No.: PCT/USO3/28226 treating conditions associated with GPCR dysfunction with the GPCR polypeptides, polynucleotides, or identified com Related U.S.
    [Show full text]
  • Salivary Gland Pathology Salivary Gland Pathology 2007 June Cheng-Chung Lin Prof
    Salivary Gland Pathology Salivary Gland Pathology 2007 June Cheng-Chung Lin Prof. in Oral Pathology Kaohsiung Med University E-mail: [email protected] Histological Classification of Salivary Gland Tumors (WHO) 1. Adenomas 2.13. Malignant myoepithelioma 1.2. Pleomorphic Adenoma 2.14. Carcinoma in PA 1.3. Basal cell adenoma (Malignant mixed tumor) 1.4. Warthin tumor 2.15. Squamous cell carcinoma 1.5. Oncocytoma(Oncocytic adenoma) 2.16. Small cell carcinoma 1.6. Canalicular adenoma 2.17. Undifferentiated carcinoma 1.7. Sebaceous adenoma 2.18. Other carcinomas 1.8. Ductal papilloma 3. Non-epithelial tumors 1.8.1 Inverted ductal papilloma 4. Malignant Lymphomas 1.8.2. Intraductal papilloma 5. Secondary tumors 1.8.3. Sialadenoma papilliferum 6. Unclassified tumors 1.9. Cystadenoma 7. Tumor-like lesions 1.9.1. Papillary cystadenoma 7.1. Sialadenosis 1.9.2. Mucinous cystadenoma 7.2. Oncocytosis 2. Carcinomas 7.3. Necrotizing sialometaplasia 7.4. Benign lymphoepithelial lesion 2.2. Mucoepidermoid carcinoma 7.5. Salivary gland cysts 2.3. Adenoid cystic carcinoma 7.6. Chronic sclerosing sialadenitis of sub- mandibular gland (Kuttner tumor) 2.4. Polymorphous low grade 7.7. Cystic lymphoid hyperplasia in AIDS Adenocarcinoma (PLGA) 2.5. Epithelial-myoepithelial carcinoma 2.6. Basal cell adenocarcinoma 2.7. Sebaceous carcinoma 2.8. Papillary cystadenocarcinoma 2.9. Mucinous adenocarcinoma 2.10. Oncocytic carcinoma 2.11. Salivary duct carcinoma 2.12. Adenocarcinoma, NOS 1 Salivary Gland Pathology While the clinical presentation of a salivary gland tumor (SGT) is usually an asymptomatic mass that may occasionally be ulcerated or cause pain, the histologic presentation is far more complex.
    [Show full text]
  • A Rare Case of Intraductal Papilloma Arising from Minor Salivary Gland in the Floor of the Mouth
    Hindawi Case Reports in Pathology Volume 2020, Article ID 8882871, 3 pages https://doi.org/10.1155/2020/8882871 Case Report A Rare Case of Intraductal Papilloma Arising from Minor Salivary Gland in the Floor of the Mouth Agnes Assao,1 Silas Antonio Juvencio de Freitas Filho ,1 Luiz Antônio Simonetti Júnior,2 and Denise Tostes Oliveira 1 1Department of Surgery, Stomatology, Pathology and Radiology (Area of Pathology), Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil 2Private Practice, Bauru, SP, Brazil Correspondence should be addressed to Denise Tostes Oliveira; [email protected] Received 12 July 2020; Revised 9 August 2020; Accepted 16 August 2020; Published 25 August 2020 Academic Editor: Tanja Batinac Copyright © 2020 Agnes Assao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. A 77-year-old woman with a rare oral intraductal papilloma arising from the minor salivary gland located on the floor of the mouth and causing the mucus retention is reported. Microscopically, the lesion was characterized by unicystic cavity exhibiting the lumen partially filled by papillary projections of the ductal epithelium with varying degree of oncocytic metaplasia. Based on the histopathological analysis, the differential diagnosis of oral intraductal papillomas and other ductal neoplasms of salivary origin are discussed. 1. Introduction to the trauma of the complete dentures. The intraoral exam- ination revealed a unique soft nodule, tender to palpation, The incidence of oral tumors arising from the salivary ductal covered with clinically normal mucosa, well-circumscribed, ffi glands, such as intraductal papillomas, is di cult to deter- sessile, located at the floor of the mouth, in the anterior left ff mine because di erent terminology has been used for the region of the mandible, measuring 1:1×0:9×0:7cm.
    [Show full text]
  • A Prospective Study on Salivary Gland Swellings – Incidence Clinico Pathological Presentation and Management
    A PROSPECTIVE STUDY ON SALIVARY GLAND SWELLINGS – INCIDENCE CLINICO PATHOLOGICAL PRESENTATION AND MANAGEMENT Dissertation submitted to THE TAMILNADU DR. M.G.R. MEDICAL UNIVERSITY CHENNAI – 600 032 In partial fulfillment of the regulations for the award of the degree of M.S. DEGREE BRANCH - II GENERAL SURGERY GOVERNMENT MOHAN KUMARAMANGALAM MEDICAL COLLEGE, SALEM APRIL 2013 CERTIFICATE BY THE GUIDE This is to certify that this dissertation entitled “A PROSPECTIVE STUDY ON SALIVARY GLAND SWELLINGS INCIDENCE CLINICO PATHOLOGICAL PRESENTATION AND MANAGEMENT” is a bonafide work done by DR.R.RAMESH in partial fulfillment of the requirement for the degree of M.S. in General Surgery, examination to be held in 2013. Date: Prof. Dr. K.SANTHI, M.S., Place: Salem Professor and Unit Chief, Department of General Surgery, Government Mohan Kumaramangalam Medical College Hospital, Salem, Tamil Nadu. CERTIFICATE This is to certify that this dissertation “PROSPECTIVE STUDY ON SALIVARY GLAND SWELLINGS - INCIDENCE CLINICO PATHOLOGICAL PRESENTATION AND MANAGEMENT” is a work done by DR.R.RAMESH under my guidance during the period of 2010-2012 this has been submitted to the partial fulfillment of the award of M.S. degree in General Surgery (Branch II) Tamil Nadu Dr.M.G.R medical university, Chennai-32. Prof. Dr. R. KATTABOMMAN, M.S., Professor & HOD of General Surgery Govt. Mohan Kumaramangalam Medical College, Salem. DEAN Govt. Mohan Kumaramangalam Medical College, Salem. DECLARATION I solemnly declare that this dissertation “PROSPECTIVE STUDY ON SALIVARY GLAND SWELLINGS INCIDENCE CLINICO PATHOLOGICAL PRESENTATION AND MANAGEMENT” was prepared by me at Government Mohan Kumaramangalam Medical College and Hospital, Salem-636030 under the guidance and supervision of Prof.Dr.K.SANTHI, M.S., Professor of General Surgery, Govt.
    [Show full text]
  • P16ink4a Immunoexpression Profile in HPV-Oral Lesions from HIV
    C S & lini ID ca A l f R o e l s Rosales-Terrazas et al., J AIDS Clin Res 2014, 6:1 a e Journal of n a r r DOI: 10.4172/2155-6113.1000411 c u h o J ISSN: 2155-6113 AIDS & Clinical Research Research Article Open Access P16ink4a Immunoexpression Profile in HPV-Oral Lesions from HIV-Infected Patients Rosales-Terrazas Estrella1, Ramírez-Amador Velia1, García-Carrancá Alejandro2,3, Guido-Jiménez Miriam2,3, Irigoyen-Camacho Esther1, Ortíz-Sánchez Elizabeth2 and Anaya-Saavedra Gabriela1* 1Universidad Autónoma Metropolitana-Xochimilco, Mexico 2Unidad de Virus y Cáncer, Instituto Nacional de Cancerología (INCan), Secretaría de Salud, Mexico 3Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad de México Abstract Background: In HIV-patients, a proportion of benign HPV-associated oral lesions (HPV-OLs) contain high risk- HPV (HR-HPV) sequences. Recent studies demonstrated a p16INK4a overexpression in HPV-induced cancer and dysplastic lesions through pRB degradation by the E7-HPV oncoprotein; so, it has been considered a surrogate marker of HR-HPV oncogenic activity. Objective: To establish the p16INK4a expression in HPV-OL from HIV-infected patients. Materials and method: A cross-sectional study was conducted in three HIV/AIDS referral centers in Mexico City. We performed histopathological diagnosis, HPV-DNA amplification, direct sequencing, and p16INK4a immunohistochemical staining in HPV-OLs. The U-Mann-Whitney, X2, and Fisher’s exact tests were used to determine the association between variables. Result: In a total of 849 adult HIV-individuals examined, we found 29 (3.4%) patients with HPV-OLs, being multifocal epithelial hyperplasia (51.7%) the most common.
    [Show full text]
  • Dec76dc4293ede47e9f0f3977e8
    07/01/2012 Oral Pathology Lecture Series :: Salivary Gland Tumours Oral Pathology Lecture Series :: Salivary Gland Tumours Salivary Glands Intro • Salivary glands are exocrine SALIVARY glands • 3 pairs of large glands GLAND located extra-orally • Major salivary glands – Parotid (serous) TUMOURS – Submandibular (mixed) – Sublingual (mucous) Prof R V SUBRAMANYAM • Minor salivary glands – Labial, lingual, palatal, Oral & Maxillofacial Pathology buccal, glossopalatine & retro molar glands • Function: Production of saliva 4/20/2008 2 Oral Pathology Lecture Series :: Salivary Gland Tumours Oral Pathology Lecture Series :: Salivary Gland Tumours Salivary Glands Intro Normal Salivary Gland Structure 4/20/2008 R V SUBRAMANYAM 3 4/20/2008 R V SUBRAMANYAM 4 Oral Pathology Lecture Series :: Salivary Gland Tumours Oral Pathology Lecture Series :: Salivary Gland Tumours Cells in Salivary Glands and Ducts CLASSIFICATION (Foote & Frazell, 1954) BENIGN MALIGNANT • Pleomorphic adenoma • Malignant mixed tumor (mixed tumor) • Mucoepidermoid tumor • Papillary cystadenoma • Squamous cell carcinoma lymphomatosa • Adenocarcinoma • Oxyphil adenoma – Adenoid cystic • Sebaceous cell – Trabecular or solid adenoma – Anaplastic – Mucous cell • Benign lymphoepithelial – Pseudoadamantine lesion – Acinic cell • Unclassified – Unlassified 4/20/2008 R V SUBRAMANYAM 5 4/20/2008 R V SUBRAMANYAM 6 1 07/01/2012 Oral Pathology Lecture Series :: Salivary Gland Tumours Oral Pathology Lecture Series :: Salivary Gland Tumours CLASSIFICATION (Thackray & Lucas, 1974) CLASSIFICATION
    [Show full text]
  • Cowden Syndrome and the PTEN Hamartoma Tumor
    Tsavaris, Laiko University Hospital, Athens, Greece; and Mitsuru Sasako, Hyogo Cancer Research Institute, Seoul National University College of Medicine, College of Medicine, Nishinomiya, Japan. Seoul, Korea (Y-JB); SWOG Statistical Center, Seattle, WA (JB); Brussels, The GASTRIC Group thanks all the patients who took part in the trials and Belgium (HB); Department of Biostatistics and Computational Biology, Dana- contributed to this research. The meta-analysis would not have been possible Farber Cancer Institute and Department of Biostatistics, Harvard School of without the active participation of the collaborating institutions that provided Public Health, Boston, MA (PC); University Clinic Leipzig, University Cancer trial data: Eastern Cooperative Oncology Group, European Organization of Center, Leipzig, Germany (FL); Biostatistics and Epidemiology department, Research and Treatment of Cancer, Fédération Francophone de Cancérologie Institut Gustave-Roussy, Universite Paris XI, Villejuif, France (SMi, J-PP); Digestive, Gastro-intestinal Tumour Study Group, International Collaborative Cancer Group, Italian Trials in Medical Oncology, Japan Clinical Oncology Department of Biostatistics, Yokohama City University, Yokohama, Japan Group, North Central Cancer Treatment Group, South West Oncology Group, (SMo); Department of Biostatistics, School of Public Health, Graduate Hospital Clinic Villarroel of Barcelona, Metaxa Cancer Hospital, Jagiellonian School of Medicine, The University of Tokyo, Tokyo, Japan (YO); Gastro- of Pireus University, and Medical College of Cracow. We thank Nicolas enterology department, University Hospital Europeen Georges Pompidou, Thamavong for his help in data management. Paris, France (PR); Department of Surgery, Hyogo College of Medicine, The first draft of this manuscript was developed at a meeting of investigators Nishinomiya, Japan (MS); Tokai Central Hospital, Kakumuhara, Japan (JS); in Sapporo, Japan, September 24–28, 2010.
    [Show full text]
  • Slow Growing Palatal Swelling- a Diagnostic Dilemma a Case Report and Indepthreview of Contemporary Literature
    IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-ISSN: 2279-0853, p-ISSN: 2279-0861.Volume 11, Issue 4.Ver. V. (Nov.- Dec. 2013), PP 110-112 www.iosrjournals.org Slow Growing Palatal Swelling- A Diagnostic Dilemma A Case Report and IndepthReview of Contemporary Literature Shrivastava K, Bailoor DN, Naidu G, Raghuvanshi V, Handa H Abstract :The adenoid cystic carcinoma is a relatively rare epithelial tumor more than half of these occur in the parotid and submandibular glands. The most common intraoral site is the palate. Its peak incidence occurs predominantly among women, between the 5th and 6th decades of life. The clinical and pathological findings typical of this tumor include slow growth, perineural invasion, potential local recurrence and distant metastasis. Histopathologically it is composed of basaloid cells with primarily myoepithelial/basal cell differentiation. It presents three patterns, cribriform, tubular and solid; the solid type is related to a poor prognosis contrary to the cribriform type, which has a better prognosis. We presented herein the case of a 26 year old male patient who presented a palatal lesion with an indepth review of literature. Keywords: Carcinoma, Adenoid cystic, Palate I. Introduction Adenoid cystic carcinoma is a rare epithelial tumor affecting the salivary glands and was first described in 18561 and at the time was referred to as cylindroma due to its unique histologic appearance.In 1928 it was renamed adenoid cystic carcinoma (ACC) and since then has been the generally accepted term for this neoplasm2.It comprises less than 1% of all malignancies of the head and neck and is the fifth most common malignancy of salivary gland origin, representing 10% of salivary gland malignancies3.As per ICD-O code 8200/3.The parotid and submandibular glands are the two most common sites for ACC accounting for 55% of the cases.
    [Show full text]
  • Histomorphological Study of Salivary Gland Neoplasms: Fifteen Year Study
    International Journal of Research in Medical Sciences Hemalata M et al. Int J Res Med Sci. 2020 Jul;8(7):2469-2476 www.msjonline.org pISSN 2320-6071 | eISSN 2320-6012 DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20202881 Original Research Article Histomorphological study of salivary gland neoplasms: fifteen year study M. Hemalata, C. P. Manjula*, Rishitha Nandi Department of Pathology, Kempegowda Institute of Medical Sciences, Bengaluru, Karnataka, India Received: 28 April 2020 Accepted: 28 May 2020 *Correspondence: Dr. C. P. Manjula, E-mail: [email protected] Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Background: The neoplasms of salivary glands are relatively uncommon and represent less than 2% of all human tumors. They are morphologically diverse, with marked heterogeneity among the different subtypes and even within the same tumor. The unpredictability in the long term outcome imposes a significant challenge in the clinical management. Methods: This is a descriptive study done in a tertiary care teaching hospital over a period of 15 years. Patient details were collected from medical case records. All specimens were evaluated for site, laterality, size, nature of the cut surface and intactness of the capsule. Two to 5 representative bits were taken from each specimen and subjected to routine fixation, processing and section cutting followed by Haematoxylin and Eosin staining. Results: A total of 138 salivary gland tumors were diagnosed from patients in the age group of 13 to 90 years with a mean age of 41.8 years.
    [Show full text]