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Malacoplakia of Urinary Bladder Malacoplakia of Urinary Bladder Vinaya Shah*, Asha Rupani**, Hemant R Pathak*** Abstract Malacoplakia is a rare chronic inflammatory condition of the urinary tract frequently involving the urinary bladder. We present a case of 35 year old female with malacoplakia of the urinary bladder which was thought to be malignant on the cystoscopic examination. The diagnosis of malacoplakia was made on the biopsy. Since clinical and cystoscopic features closely simulate bladder malignancy, it is not possible to make an accurate diagnosis of malacoplakia without the histopathological examination. Genitourinary malacoplakia has to be considered in patients with recurring urinary tract infections and mass lesions as it can avoid unnecessary radical surgical treatment. Introduction large macrophages. The basophilic inclusions were alacoplakia is an uncommon chronic positive for Prussian blue and Von-Kossa, confirming the presence of iron and calcium deposits (Fig. 1). M inflammatory condition of the urinary The diagnosis of malacoplakia was made and the tract with 40 per cent of the cases involving patient was put on antibiotic treatment. Her symptoms the urinary bladder.1,2 We hereby present a resolved and she currently is on regular follow up. case of malacoplakia of the urinary bladder Discussion which was thought to be malignant on the Malacoplakia is a rare inflammatory cystoscopic examination. condition of the urinary tract observed more Case Report often in females in fifth decade.1,2 In nearly A 35 year old female presented with pain in the 75% of the reported cases, the genitourinary right flank, fever, weight loss and anorexia since 2 tract is involved.3 Other organs like months. Urine examination showed numerous pus gastrointestinal tract, retroperitoneum, skin, cells. On ultrasonography, the right kidney showed pyonephrosis with dilated, tortuous upper right ureter lungs, brain and tonsils can also be 1,2,3 and a vesical calculus. Percutaneous nephrostomy involved. Patients of malakoplakia of was performed and frank pus was aspirated from the urinary bladder usually present with lower right kidney, however the culture did not show any urinary tract irritative symptoms like growth. Cystoscopy revealed multiple whitish tiny frequency, dysuria and haematuria. Fever nodules in the bladder mucosa with both ureteric and flank mass usually indicate renal orifices normal. Malignancy was suspected and a biopsy was performed. Sections showed hyperplastic involvement which could be a possibility in urothelium and underlying lamina propria showed our case also.3,4 Association of hydronephrosis, numerous large macrophages with abundant foamy hydroureter, pyonephrosis and malakoplakia eosinophilic cytoplasm, lymphocytes, plasma cells and of urinary bladder with vesicoureteral reflux neutrophils. Few of the macrophages also showed is also reported.1,2,4,5 Radiology of the affected basophilic inclusions with a halo around it in the cytoplasm resembling Michaelis-Gutmann bodies. organ may show poorly enhancing infiltrating 1,4 Special stains were performed. Positivity for Per-iodic parenchymal masses. On cystoscopy, urinary acid Schiff was noted within the cytoplasm of the bladder may be small and contracted with multiple polypoid masses or plaques of yellow *Assoc Prof, **Lecturer, Dept of Pathology; ***Prof or fleshy red colour with areas of hyperaemia and Head, Dept of Urology; TN Medical College and and ulceration. This can lead to the BYL Nair Ch. Hospital, Mumbai - 400 008. misdiagnosis of malignancy on cystoscopy.1,2 144 Bombay Hospital Journal, Vol. 52, No. 1, 2010 Generally, upper urinary tract involve- ment requires surgical intervention, while most cases of urinary bladder involvement can be managed with antibiotics and endoscopic resection.3 Ascorbic acid and bethanechol chloride are also administered postoperatively, but the results have been variable.3,5 Our patient responded well to the antibiotic treatment. Though benign, malacoplakia can be recurring and requires Fig. 1 : a) Microphotograph showing numerous close follow up. It is also known to be histiocytes and other inflammatory cells in the associated with urothelial carcinoma.7 Since lamina propria of the urinary bladder along with clinical and cystoscopic features closely the distinct cytoplasmic basophilic inclusions in the simulate bladder malignancy, it is not possible macrophages (arrow, H&E, 400X). b) PAS positivity to establish a correct diagnosis of of the histiocytes (arrow, PAS, 400X). c) Prussian malacoplakia except by the histopathological Blue stain positivity of the inclusions (arrow, PB, examination. This could also be due to 100X). d) Von-Kossa positivity of the intra- variable appearance of the lesions on cytoplasmic inclusions (arrow, Von- Kossa, 400X). cystoscopy. Hence urinary bladder Microscopically, the characteristic cells are malacoplakia should be considered in patients the large eosinophilic von Hansemann with recurring urinary tract infections and macrophages with presence of basophilic mass lesions and its early identification can inclusions, the pathognomonic Michaelis- help to avoid unnecessary surgical treatment. 1-3 Gutmann bodies within the cytoplasm. References These intracellular inclusions represent 1. Minor L, Lindgren BW. Malacoplakia of the bladder phagocytosed bacterial components which in a 16-year-old girl. J Urol 2003; 170 : 568-9. result from the inadequate killing of bacteria 2. Dubey NK, Tavadia HB, Hehir M. Malacoplakia: a by macrophages that exhibit defective case involving epididymis and a case involving a phagolysosomal activity. Partially digested bladder complicated by calculi. J Urol 1988; 139 : bacteria accumulate in the macrophages 359-61. 3. Long JP Jr, Althausen AF. Malacoplakia: a 25- leading to the deposition of calcium and iron year experience with a review of the literature. J 2, 3 on residual bacterial glycolipid. This can be Urol 1989; 141 : 1328-31. demonstrated by special stains as in our case. 4. Cury J, Coelho RF, Franco M, Srouqi M. Renal Almost 72-90% of cases are associated with parenchymal malacoplakia with pleural effusion. coliform infection, predominantly Escherichia Clinics 2007; 62 : 87-8. 5. Koroku M, Tanda H, Katoh S , Onishi S, Nakajima coli.1,3 An increased frequency of malakoplakia H, Nanbu A, et al. Malacoplakia in the ureter and in immunocompromised patients is also well bladder. Hinyokika Kiyo 2005; 51 : 183-5. established and noted in upto 40% of the 6. Wu IW, Yu CC, Wu CT, Jung SM, Huang JY. cases.1 There is also a report with Xanthogranulomatous pyelonephritis and synchronous appearance of xanthogranulo- malacoplakia of the bladder in a middle aged female. matous pyelonephritis and malacoplakia of J Nephrol 2006; 19 : 222-4. 7. Darvishian F, Teichberg S, Meyersfield S, the bladder, suggesting a common patho- Urmacher CD. Concurrent malacoplakia and genesis for these two diseases in which the papillary urothelial carcinoma of the urinary urinary obstruction is the promoting factor.6 bladder. Ann Clin Lab Sci 2001; 31 : 147-50. Bombay Hospital Journal, Vol. 52, No. 1, 2010 145.
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