The Journal of Osteopathy June 1903
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A Critical Review of Graminex Flower Pollen Extract for Symptomatic Relief of Lower Urinary Tract Symptoms (LUTS) in Men
Flower Pollen Extract and its Effect on the Urinary Tract A Critical Review of Graminex Flower pollen extract for Symptomatic Relief of Lower Urinary Tract Symptoms (LUTS) in Men Walter G. Chambliss, Ph.D. National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi, University, Ms. 38677 January 12, 2003 gave no treatment 77% of the time to men with Objective mild symptoms. Prescription drugs were given 89% of the time and surgery was conducted on To review published data concerning the ability 1% of the time for men with moderate of a Graminex’s Flower Pollen Extract to provide symptoms. The primary therapeutic treatment symptomatic relief in men suffering from lower was alpha(1)-adrenoceptor antagonists such as urinary tract symptoms (LUTS). terazosin hydrochloride (Hytrin®) that provides symptomatic relief but has not be shown to Introduction provide long-term effects on the incidence of surgery, acute urinary obstruction or other The National Institutes of Health (NIH) estimates complications of BPH4. The need exists for safe, 9 million men suffer from symptoms related to effective products that can be used by men to an enlarged prostate and 400,000 surgeries are treat mild to moderate LUTS in lieu of or in conducted each year in the U.S.1 The term lower addition to prescription drugs. This review urinary tract symptoms (LUTS) is used to focuses on the potential for flower pollen extract, describe symptomatology in men who are a dietary supplement, to fill this therapeutic void. experiencing one or more symptoms on the International Prostate Symptom Score (IPSS) Graminex Flower Pollen Extract is a questionnaire that includes urgency, daytime standardized extract of rye pollen (Secale and nighttime urinary frequency, hesitancy, cereale), corn pollen (Zea mays) and timothy intermittency, sensation of incomplete voiding, pollen (Phleum pratense). -
With All the Attention on the Nation's Health Care Policies These Days, It
With all the attention on the nation's health care policies these days, it seems appropriate to look back one hundred and twenty years ago, to 1890 when medical problems of local citizens were treated by health care workers plying their trade in Menomonie. With city's population approaching the 5,000 mark it was necessary to have competent medical doctors to care for everyday ills and more serious medical needs. There was a hospital providing aid for expectant mothers that was operated by a Mrs. Finley, perhaps one of a handful of midwives in town. However most hospitals established in the second half of the 19th century were primarily established to provide care, not treatment, of the inhabitants. Physicians customarily diagnosed and treated illness, delivered babies, and even performed surgery in their patients' homes or in their offices. By the late 1880s and early 1890s Menomonie had eight physicians; E. O Baker, E. H. Grannis, E. P. Wallace, F. R. Reynolds, D. H. Decker, J. V. R. Lyman, W. F. Nichols, and much to the relief of lady patients, there was a woman doctor, Miss Kate Kelsey, ready to serve. However many families at that time relied on home remedies that had been handed down by family tradition, and the newspapers and magazines of the time were filled with advertisements of such products as the Kickapoo Indian Sagwa. It was a blend of roots, herbs, and bark, concoction that "purifies the blood, and cures all diseases of the stomach, liver, and kidneys." A "Dr. Buckland" produced a "Scotch Oats Essence" that would cure, " sleeplessness, paralysis, an opium habit, drunkenness, neuralgia, sick headaches, sciatica, nervous dyspepsia, locomotor ataxia, headache, ovarian neuralgia, nervous exhaustion, epilepsy, and St. -
Therapeutic Results of Defined Pollen-Extract in Patients with Chronic Prostatitis Or BPH Accompanied by Chronic Prostatitis
Flower Pollen Extract and its Effect on the Prostate PROSTATE SUPPORT: Therapeutic Results of Defined Pollen-Extract in Patients with Chronic Prostatitis or BPH Accompanied by Chronic Prostatitis L. Ebeling Pharma Stroschein Hamburg, FRG Introduction In a double-blind study with 61 patients and a simultaneously carried out open examination Depending mainly upon analysis of prostatic with 118 patients Leadner (9) stated in the fluid and angloamerican classification divides verum-group a normalization of initially the benign painful diseases of the prostate into pathological palpation findings and leucocytosis four categories: Acute bacterial prostatitis, of prostatic fluid in 94% of patients with chronic chronic bacterial prostatitis, non-bacterial prostatitis who were treated with pollen-extract. prostatitis, and prostatodynia (1). 6% of the patients showed unchanged results, aggravations were not observed. In the placebo- According to findings of Weidner (2) the largest group 48% showed normalization, 34% group, the prostatodynia (vegetative urogenital demonstrated an unchanged status and in 18% syndrome), covers 52.4%. Besides clinical of the patients the findings were deteriorated. symptoms and normal laboratory findings the The results of treatment in the open trial following urodynamics changes are revealed only small differences in comparison to characteristic: Elevation of the maximum therapeutic effects in the verum-group which can urethral closure and reduced peak urine flow be rated as accidental. Takeuchi (10) rates (3,4,5). demonstrated in a clinical study with 25 BPH- In approximately 40% of non-bacterial prostatitis patients in stage 1 or 2 under treatment with the microbiological examination is negative (2) pollen-extract besides the elevation of peak whereas by definition leucocytosis in the urine flow rate a significant (p < 0.05) decrease prostatic fluid can be demonstrated. -
WITH SUPPLEMENT. SATURDAY, JULY 17, 1920. the SURGERY Of
s1~ M-1- t1t Br Med J: first published as on 17 July 1920. Downloaded from The Journal of the British Medical Associaton. INCLUDING AN EPITOME OF CURRENT MEDICAL LITERATUfhr WITH SUPPLEMENT. No. 3107.- SATURDAY, JULY 17, 1920. Price 1/- ~~ ~ ~ ~ ~ ~ ~ NEW EDITION, THOROUGHLY REviSED. By FREDERICK W. PRICE, M.D., F.R.S.(Edln.), The SURGERY of the HEART. Physieian to the Great Northern Central HospitaL http://www.bmj.com/ By Sir CHARLES A BALLANCE, K.C.M.G., THE ESSENTIALS OF HISTOLOGY: Physician to the National Hospital for Diseases C.B., M.V.O., M.S., F.IC.C.S., Deseriptive and Practieal. of the Heart, London. Conisulting Surgeon to St. Thomas's Hospital, etc. For the Use of Students. 8 vo. net. By Sir EDWARD SHARPEY SCHAFER, LL.D., DISEASES OF THE HEART. Illustrated by 48 figures. Demy 10/6 D.Sc., M.D., F.R.S., Professor of Physiology Their Diagnosis, Prognosis, and Treatment MACMILLAN & CO. and Histology in Edinburgh University. by Modern Methods. With many Illustrations, several of which are With a Chapter on the Blectro-Cardiograph. By A. C. MAGIAN, M.D., Coloured. ELEVENTH EDITION. 8vo. 14s. net. Surgeon to the Manchester Prench Hospital and to Deny 8vo, 484 pp. Veryfully Illustrated. 218. net- the Wood Clinic for Genito-Urinary Diseases. LONGMANS, GREEN & CO Lancet.-"By great care, and by the use of an MANUAL OF VENEREAL DISEASES. 39, Paternoster Rtow, London, B C. 4. amazing amounit of material, he has accomplished 2ND EDITION. With 61 Illustrations. 10s. 6fd. net. what many readers have been waiting for, giving on 26 September 2021 by guest. -
9Th Srca Symposium on the Cerebellum Taipei, May 2018
The Cerebellum (2019) 18:1–21 https://doi.org/10.1007/s12311-018-0953-2 ABSTRACTS 9TH SRCA SYMPOSIUM ON THE CEREBELLUM TAIPEI, MAY 2018 PP1 1Departments of Neurology, Maynei Hayeshua Medical Center , Bnei Barak , Israel Different types of multiple-synapse boutons in the cerebellar cortex 2 Meir Medical Center, Kfar-Saba, Israel between physically enriched and ataxic mutant mice 3 The Sackler Faculty of Medicine, Tel-Aviv University, Israel Kim H. 1,OhS.1, Lee S.1,NaJ.1, Lee K.J.2, Rhyu I.J.1 Corresponding author’s e-mail: [email protected] 1Department of Anatomy, Korea University College of Medicine, Seoul Objective: To describe the clinical and epidemiological features of the 02841, Korea Jewish Yemenite pocket of Machado-Joseph disease in Israel 2 Laboratory of Synaptic Circuit Plasticity, Department of Structure & Background: Machado-Joseph Disease known also as SCA3 is an Function of Neural Network, Korea Brain Research Institute, Daegu 700- autosomal dominant progressive neurologic disorder due to a hetero- 010, Korea zygous (CAG)n trinucleotide repeat expansion encoding glutamine repeats in the ataxin-3 gene (ATXN3; on chromosome 14q32 , char- Corresponding author’s e-mail: [email protected] acterized principally by ataxia, spasticity, and ocular movement ab- normalities (OMIM # 109150). Traditionally, all patients were consid- Objectives: Experience-dependent synapse remodeling is associated with ered as the offspring of two Portuguese families who lived in the information storage in the nervous system. Neuronal synapses show alter- Azorean islands i.e. the Machado and the Joseph families. Therefore, ation in various neurological and cognitive disorders in their structure and the disease was first known as Azorean Degeneration. -
Study Protocol
2017N317982_00 CONFIDENTIAL 2018N388745_00 GlaxoSmithKline group of companies 206899 TITLE PAGE Protocol Title: A Phase IIa Single-Center, Open-Label Study Evaluating the Pharmacokinetics of Repeat Oral Doses of Gepotidacin (GSK2140944) in Adult Female Participants With Uncomplicated Urinary Tract Infection (Acute Cystitis) Protocol Number: 206899 Short Title: Phase IIa Pharmacokinetic Study of Oral Gepotidacin (GSK2140944) in Participants With Uncomplicated Urinary Tract Infection (Acute Cystitis) Compound Number: GSK2140944 Sponsor Name and Legal Registered Address: GlaxoSmithKline Research & Development Limited 980 Great West Road Brentford Middlesex, TW8 9GS UK Sponsor Contact Address: GlaxoSmithKline 1250 South Collegeville Road PO Box 5089 Collegeville, PA 19426-0989 USA Medical Monitor Name and Contact Information can be found in the Study Reference Manual Regulatory Agency Identifying Number: IND 111885 Approval Date: 10-MAY-2018 Copyright 2018 the GlaxoSmithKline group of companies. All rights reserved. Unauthorized copying or use of this information is prohibited. 1 2018N388745_00 PPD PPD 2017N317982_00 CONFIDENTIAL 2018N388745_00 206899 TABLE OF CONTENTS PAGE 1. SYNOPSIS...............................................................................................................6 2. SCHEDULE OF ACTIVITIES ...................................................................................8 3. INTRODUCTION....................................................................................................11 3.1. Study Rationale -
A Simulation Case for Emergency Medicine Residents
Open Access Technical Report DOI: 10.7759/cureus.2984 Neurosyphilis: A Simulation Case for Emergency Medicine Residents Chana Rich 1 , Dimitrios Papanagnou 2 , David Curley 3 , Xiao Chi Zhang 2 1. Emergency Medicine, Alpert Medical School of Brown University , Providence, USA 2. Emergency Medicine, Thomas Jefferson University, Philadelphia, USA 3. Emergency Medicine, Alpert Medical School of Brown University, Providence, USA Corresponding author: Xiao Chi Zhang, [email protected] Abstract Neurosyphilis is a dangerous and increasingly more prevalent sexually transmitted infection of the central nervous system caused by the bacterium Treponema pallidum that can present during the advanced stages of the disease (tertiary syphilis). Health care providers must remain vigilant in screening for syphilis in patients with high-risk behaviors as a delay in diagnosis and treatment may lead to symptom progression and debilitating sequelae years later. To date, there have been no published simulation case studies on neurosyphilis. This simulation case, based on a real patient encounter, is written for emergency medicine residents to diagnose and manage a patient presenting with the sequelae of neurosyphilis. This case was run for four separate iterations at a simulation center with two residents and an attending physician acting as confederates. Following the case, learners were provided with bedside debriefing, and a question and answer session. Based on post-simulation qualitative assessment, junior residents alone were less likely to perform a comprehensive integumentary exam without the presence of senior residents, although both groups failed to elicit pertinent sexual history until they discovered syphilitic lesions. After case completion and debriefing, all learners were able to demonstrate the understanding of the primary learning objectives. -
Differential Diagnosis and Medical Therapeutics a Treatise on Clinical Medicine
DIFFERENTIAL DIAGNOSIS AND MEDICAL THERAPEUTICS A Treatise on Clinical Medicine Third Edition P Siva Rama Krishna Rao BSc MBBS (Madra) MD (Andhr) FRCP (Glasg) FRSM (London) FICA (NY) FCCP (USA) FIMSA (India) FIAMS (India) FICP (India) Formerly Professor and Head Department of Medicine Andhra Medical College First Physician King George Hospital Visakhapatnam, Andhra Pradesh, India Additional Director in the office ofBrothers Directorate of Medical Education Government of Andhra Pradesh Forewords IV Rao David R London Jaypee The Health Sciences Publisher New Delhi | London | Philadelphia | Panama Jaypee Brothers Medical Publishers (P) Ltd Headquarters Jaypee Brothers Medical Publishers (P) Ltd 4838/24, Ansari Road, Daryaganj New Delhi 110 002, India Phone: +91-11-43574357 Fax: +91-11-43574314 Email: [email protected] Overseas Offices J.P. Medical Ltd Jaypee-Highlights Medical Publishers Inc Jaypee Medical Inc 83, Victoria Street, London City of Knowledge, Bld. 237, Clayton 325 Chestnut Street SW1H 0HW (UK) Panama City, Panama Suite 412, Philadelphia, PA 19106, USA Phone: +44 20 3170 8910 Phone: +1 507-301-0496 Phone: +1 267-519-9789 Fax: +02 03 0086180 Fax: +1 507-301-0499 Email: [email protected] Email: [email protected] Email: [email protected] Jaypee Brothers Medical Publishers (P) Ltd Jaypee Brothers Medical Publishers (P) Ltd 17/1-B Babar Road, Block-B, Shaymali Bhotahity, Kathmandu Mohammadpur, Dhaka-1207 Nepal Bangladesh Phone: +977-9741283608 Mobile: +08801912003485 Email: [email protected] Email: [email protected] Website: www.jaypeebrothers.com Website: www.jaypeedigital.com Brothers © 2015, Jaypee Brothers Medical Publishers The views and opinions expressed in this book are solely those of the original contributor(s)/author(s) and do not necessarily represent those of editor(s) of the book. -
Overview of Gynecologic Oncology
Overview of Gynecologic Oncology “The Blue Book” R. Kevin Reynolds, MD 11th Edition, Revised February 2010 www.med.umich.edu/obgyn/gynonc Gyn Oncology.......................................................................734-764-9106 Cancer Center Answer Line ...............................................800-865-1125 Contents Gyn Tumors Page Breast Cancer ......................................................................... 1 Cervical Cancer 6 Endometrial Cancer................................................. 17 Gestational Trophoblastic Neoplasia 24 Ovarian Cancer ....................................................... 29 Sarcomas 44 Vaginal Cancer........................................................ 51 Vulvar Cancer 53 Associated Treatment Modalities Nutrition, Fluid and Electrolytes 66 Radiation Therapy ................................................... 71 Chemotherapy 75 Perioperative Management ..................................... 94 Tools and Equipment for the Art of Surgery 108 Appendix Out-of-Date Staging Rules .................................... 123 GOG Toxicity Criteria 125 Performance Status............................................... 129 Web Resources 130 Special thanks to William Burke, MD, and to Catherine Christen, PharmD Favorite Quotes "Statistics are no substitute for judgment." Henry Clay "A leading authority is anyone who has guessed right more than once." Frank A. Clark "Well done is better than well said." Ben Franklin "Trust me. I'm a doctor" Donald H. Chamberlain, MD "To err is human; to repeat the -
The Incidence of Venereal Diseasein Interwar
Medical History, 1993, 37: 167-186. MEASURING "THE SOCIAL EVIL": THE INCIDENCE OF VENEREAL DISEASE IN INTERWAR SCOTLAND by ROGER DAVIDSON * THE CONTEXT The celebrated conclusion of the Royal Commission on Venereal Diseases in 1916 that "the number of persons... infected with syphilis, acquired or congenital, cannot fall below 10 per cent of the whole population in the large cities, and the percentage affected by gonorrhoea must greatly exceed this proportion"' continued to inform the social politics surrounding the administration of sexually transmitted diseases in Scotland for much of the interwar period. It fuelled contemporary crisis perceptions of the incidence of the "social evil" and of its implications for the health, efficiency, and social morality of the nation, and continued to be quoted by Scottish public health administrators well into the 1920s.2 In the Scottish popular and medical press, in the proceedings of Scottish local authorities and the Convention of Royal Burghs, and in the representations of medico-moral pressure groups operating north of the Border, VD remained for many years a menacing "scourge" and "hidden plague" sapping the vitality of the race.3 Similar perceptions served in part to underpin the sustained campaign in interwar Scotland for more stringent local authority powers to combat the spread of venereal disease, including the introduction of compulsory notification and/or compulsory treatment for those infected.4 Armed with the rhetoric of "national efficiency" and * Roger Davidson, Ph.D., F.R.Hist.S., Senior Lecturer in Economic and Social History, University of Edinburgh, 50 George Square, Edinburgh EH8 9JY. I am indebted to Dr Michael Barfoot, Archivist of Lothian Health Board's Medical Archive Centre, for his generous advice on primary sources, and to Dr A. -
PROSTATIC SURGERY by T
Postgrad Med J: first published as 10.1136/pgmj.25.286.373 on 1 August 1949. Downloaded from 373 PROSTATIC SURGERY By T. J. D. LANE, M.D. Surgeon to Meath Hospital, Dublin This communication presents a critical survey There is no place for radiation or the use of the of the developtments in the treatment of prostatic sex hormones in the treatment of the adeno- obstruction since they were last reviewed by matous or fibrous prostate. Because of the Clifford Morson (I935) in 1935. The opportunity possibility of latent cancer, the administration of is also taken to give a fairly detailed account of testosterone may not be free from risk and I have our present practice at the Urological Department never seen it do any objective good. On the of the Meath Hospital. other hand the control of such coincidental lesions While the last 14 years have indeed been vintage as diabetes mellitus or urinary infection may years for the urologist, unfortunately they have not greatly benefit the patient. brought us nearer the discovery of the cause of The questions which arise regarding the various bladder neck obstruction, whether this be aspects of surgical intervention in prostatic adenomatous,* fibrous, or malignant. But when obstruction will be discussed in the following Huggins (194I) showed the dependence of the order : Protected by copyright. prostatic cancer cell on male sex hormone, i. Who should operate ? although he did not find the cause of these 2. What are the indications for operation ? tumours, he certainly transformed our outlook on the disease and brought hope to the hopeless. -
Journal of Postgraduate Medicine N
President, Staff Society Journal of Postgraduate Medicine N. A. Kshirsagar Volume 49, Issue 2, April-June, 2003 Editor Atul Goel Print ISSN 0022-3859 CD ISSN 0972-2823 Contents Associate Editors Sandeep Bavdekar Editorial Lakshmi Rajgopal Antibiotic resistance: Unless we act soon! Consulting Editors Bavdekar SB ...................................................................................................................................... 107 Nithya Gogtay Original Article Original Articles Sanjay Mehta Recruitment of subjects for clinical trials after informed consent: Does gender and Vinita Salvi educational status make a difference? Managing Editor Gitanjali B, Raveendran R, Pandian DG, Sujindra S .......................................................................... 109 D. K. Sahu Brief Reports Members Human immunodeficiency virus type 1 infection in patients with severe falciparum Amita Athavale malaria in urban India Abhay Dalvi Khasnis AA, Karnad DR ..................................................................................................................... 114 Sucheta Dandekar Hemant Deshmukh Antimicrobial-induced endotoxaemia in patients with sepsis in the field of acute Anil Patwardhan pyelonephritis Preeti Mehta Giamarellos-Bourboulis EJ, Perdios J, Gargalianos P, Kosmidis J, Giamarellou H ............................. 118 Nalini Shah A comparison of intravenous ketoprofen versus pethidine on peri-operative analgesia Lalita Tuteja and post-operative nausea and vomiting in paediatric vitreoretinal surgery Pradeep