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As of October 31, 2017 Pfizer Pipeline As of October 31, 2017 Disclaimer ● As some programs are still confidential, some candidates may not be identified in this list. In these materials, Pfizer discloses Mechanism of Action (MOA) information for some candidates in Phase 1 and for all candidates from Phase 2 through regulatory approval. With a view to expanding the transparency of our pipeline, Pfizer is including new indications or enhancements, which target unmet medical need or represent significant commercial opportunities. The information contained on these pages is correct as of October 31, 2017. ● Visit Pfizer.com/pipeline, Pfizer’s online database where you can learn more about our portfolio of new medicines and find out more about our Research and Development efforts around the world. 2 Table of Contents Pfizer Pipeline Snapshot 4 Inflammation and Immunology 5 Metabolic Disease and Cardiovascular Risks 6 Neuroscience 7 Oncology 8-10 Rare Diseases 11 Vaccines 12 Biosimilars and Other Areas of Focus 13 Projects Discontinued Since Last Update 14 Backup: Regulatory Designation Definitions 15-16 3 Pfizer Pipeline Snapshot Pfizer Pipeline 10 programs advanced Snapshot as of or are new Discovery October 31, 2017 Projects Phase 1 Phase 2 Phase 3 Registration Total 38 19 28 10 95 Pipeline represents progress of R&D Recent Approvals programs as of October 31, 2017 - Bavencio (avelumab) for Merkel Cell Carcinoma (EU) 1 project discontinued since - Besponsa (inotuzumab ozogamicin) for Acute Lymphoblastic Leukemia (US) Included are 62 NMEs, 25 additional last update indications, plus 8 biosimilars - Lyrica CR (once a day dosing) (US) - Mylotarg (gemtuzumab ozogamicin) for Acute Myeloid Leukemia (US) 13 programs advanced Pfizer Pipeline or are new Snapshot as of Discovery August 1, 2017 Projects Phase 1 Phase 2 Phase 3 Registration Total 38 17 32 12 99 Pipeline represents progress of R&D programs as of August 1, 2017 Recent Approvals - Bavencio (avelumab) for 2nd Line Urothelial Carcinoma (US) Included are 61 NMEs, 29 additional 5 projects discontinued since indications, plus 9 biosimilars last update - Besponsa (inotuzumab ozogamicin) for Acute Lymphoblastic Leukemia (EU) - Trumenba (meningococcal group B vaccine) for Active Immunization to Prevent Invasive Meningococcal Disease (EU) 4 New Molecular Entity New Indication or Pfizer Pipeline – October 31, 2017 Enhancement Therapeutic Area Compound Name Mechanism of Action Indication Phase ►Xeljanz (tofacitinib) JAK Inhibitor Ulcerative Colitis Registration ►Xeljanz (tofacitinib) JAK Inhibitor Psoriatic Arthritis Registration Rheumatoid Arthritis, *Inflammatory Dekavil IL-10 Phase 2 Bowel Disease (Biologic) PF-04965842 JAK Inhibitor Atopic Dermatitis Phase 2 PF-06480605 TNFSF15 Blocker Ulcerative Colitis (Biologic) Phase 2 PF-06650833 IRAK4 Rheumatoid Arthritis Phase 2 Inflammation Alopecia Areata, Rheumatoid Arthritis, and PF-06651600 JAK3 Phase 2 Ulcerative Colitis Immunology Alopecia Areata, Psoriasis, Ulcerative PF-06700841 TYK2/JAK1 Phase 2 Colitis interleukin 7 receptor precursor PF-06342674 Diabetes Mellitus-Type 1 (Biologic) Phase 1 Modulator acetyl-Coenzyme A carboxylase PF-06423264 Acne Phase 1 alpha+beta Inhibitor PF-06817024 Cytokine Modulator Atopic Dermatitis (Biologic) Phase 1 interferon, beta 1, fibroblast PF-06823859 Lupus (Biologic) Phase 1 (IFNB1) Blocker ►PF-06826647 TYK2 Inhibitor Inflammatory Bowel Disease Phase 1 * Note: Additional indications in Phase 1 ►Indicates that the project is either new or has progressed in phase since the previous portfolio update of Pfizer.com 5 New Molecular Entity Pfizer Pipeline – October 31, 2017 (cont’d) Therapeutic Area Compound Name Mechanism of Action Indication Phase ertugliflozin (PF-04971729) SGLT-2 Inhibitor Diabetes Mellitus-Type 2 Registration Acetyl CoA-Carboxylase (ACC) Non-Alcoholic Steatohepatitis (NASH) ►PF-05221304 Phase 2 Inhibitor (FAST TRACK) Diacylglycerol O-Acyltransferase 2 Metabolic Disease PF-06427878 Hyperlipidemia Phase 1 (DGAT2) Inhibitor and Cardiovascular Risks PF-06667272 Myeloperoxidase Inhibitor Non-Alcoholic Steatohepatitis (NASH) Phase 1 PF-06835919 Ketohexokinase (KHK) Inhibitor Non-Alcoholic Steatohepatitis (NASH) Phase 1 Diacylglycerol O-Acyltransferase 2 PF-06865571 Non-Alcoholic Steatohepatitis (NASH) Phase 1 (DGAT2) Inhibitor ►Indicates that the project is either new or has progressed in phase since the previous portfolio update of Pfizer.com Indicates Regulatory Designation – See Definitions in Backup 6 New Molecular Entity Pfizer Pipeline – October 31, 2017 (cont’d) Therapeutic Area Compound Name Mechanism of Action Indication Phase OA Signs and Symptoms (FAST TRACK), tanezumab Nerve Growth Factor Inhibitor Chronic Low Back Pain (FAST TRACK), Phase 3 Cancer Pain (Biologic) PF-06372865 GABA A Receptor Agonist Epilepsy Phase 2 PF-06649751 Dopamine 1 activator Parkinson's Disease Phase 2 PF-04958242 AMPA Ion Channel Schizophrenia Phase 1 Neuroscience Combination: Casein kinase I PF-05251749 Alzheimer’s Disease Phase 1 delta/epsilon Gamma secretase complex PF-06648671 Alzheimer’s Disease Phase 1 Modulator PF-06669571 Dopamine 1 activator Cognitive Disorder Phase 1 PF-06751979 Enzyme Inhibitor Alzheimer’s Disease Phase 1 ►PF-06852231 cholinergic modulator Alzheimer’s Disease Phase 1 ►Indicates that the project is either new or has progressed in phase since the previous portfolio update of Pfizer.com Indicates Regulatory Designation – See Definitions in Backup 7 New Molecular Entity New Indication or Pfizer Pipeline – October 31, 2017 (cont’d) Enhancement Therapeutic Area Compound Name Mechanism of Action Indication Phase 1st Line Chronic Myelogenous Leukemia ►Bosulif (bosutinib) Abl and src-family Kinase Inhibitor Registration (ORPHAN - U.S., E.U., PRIORITY REVIEW) 1st Line Acute Myeloid Leukemia (E.U.) Mylotarg CD33-targeted cytotoxic agent Registration (Biologic) (ORPHAN - E.U.) Sutent (sunitinib) Multiple Tyrosine Kinase Inhibitor Renal Cell Carcinoma Adjuvant Registration 2nd Line Non-Small Cell Lung Cancer Bavencio (avelumab) Anti PD-L1 Inhibitor Phase 3 (Biologic) 1st Line Non-Small Cell Lung Cancer Bavencio (avelumab) Anti PD-L1 Inhibitor Phase 3 (Biologic) Bavencio (avelumab) Anti PD-L1 Inhibitor 1st Line Gastric Cancer (Biologic) Phase 3 Oncology Bavencio (avelumab) Anti PD-L1 Inhibitor 3rd Line Gastric Cancer (Biologic) Phase 3 (1 of 3) Platinum Resistant/Refractory Ovarian Bavencio (avelumab) Anti PD-L1 Inhibitor Phase 3 Cancer (Biologic) Bavencio (avelumab) Anti PD-L1 Inhibitor 1st Line Ovarian Cancer (Biologic) Phase 3 Bavencio (avelumab) Anti PD-L1 Inhibitor 1st Line Urothelial Cancer (Biologic) Phase 3 1st Line Renal Cell Carcinoma (Biologic) Bavencio (avelumab) Anti PD-L1 Inhibitor Phase 3 (Combo w/ Inlyta (axitinib)) Locally Advanced Squamous Cell Carcinoma Bavencio (avelumab) Anti PD-L1 Inhibitor Phase 3 of the Head and Neck (Biologic) 1st Line EGFR-activating mutant Non-Small dacomitinib (PF-00299804) pan-HER Inhibitor Phase 3 Cell Lung Cancer (ORPHAN - U.S.) ►Indicates that the project is either new or has progressed in phase since Indicates Regulatory Designation – See Definitions in Backup the previous portfolio update of Pfizer.com 8 New Molecular Entity New Indication or Pfizer Pipeline – October 31, 2017 (cont’d) Enhancement Therapeutic Area Compound Name Mechanism of Action Indication Phase Ibrance (palbociclib) CDK 4,6 Kinase Inhibitor High Risk Early Breast Cancer Phase 3 Early Breast Cancer in Adjuvant Setting, Ibrance (palbociclib) CDK 4,6 Kinase Inhibitor Phase 3 *Cancer Ibrance (palbociclib) CDK 4,6 Kinase Inhibitor HER2+ Breast Cancer Phase 3 Renal Cell Carcinoma Adjuvant, *Cancer combo w/ Merck’s Keytruda (PD-1, Inlyta (axitinib) VEGF Tyrosine Kinase Inhibitor Phase 3 pembrolizumab), *Combo w/ Xalkori for RCC 1st Line ALK Non-Small Cell Lung Cancer lorlatinib (PF-06463922) ALK Inhibitor Phase 3 (ORPHAN - U.S.) Germline BRCA Mutated Metastatic Breast talazoparib (MDV3800) PARP inhibitor Phase 3 Cancer Metastatic Hormone Sensitive Prostate Xtandi (enzalutamide) Androgen receptor inhibitor Phase 3 Cancer Non-metastatic Castrate Resistant Prostate Oncology Xtandi (enzalutamide) Androgen receptor inhibitor Phase 3 Cancer (2 of 3) Non-metastatic High Risk Hormone Xtandi (enzalutamide) Androgen receptor inhibitor Phase 3 Sensitive Prostate Cancer 1st Line Merkel Cell Carcinoma (E.U.), Combo w/ PF-04518600 (OX40) for: Squamous Cell Carcinoma of the Head and Neck, Combo w/ PF-05082566 (41BB) for: Bavencio (avelumab) Anti PD-L1 Inhibitor Phase 2 Melanoma, Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Squamous Cell Carcinoma of the Head and Neck, Triple- Negative Breast Cancer, *Cancer (Biologic) glasdegib (PF-04449913) SMO (smoothened) antagonist Acute Myeloid Leukemia, *Cancer Phase 2 2nd Line ALK Non-Small Cell Lung Cancer lorlatinib (PF-06463922) ALK Inhibitor Phase 2 (BREAKTHROUGH, ORPHAN - U.S.) Xtandi (enzalutamide) Androgen receptor inhibitor Hepatocellular Carcinoma Phase 2 Indicates Regulatory Designation – See Definitions in Backup * Note: Additional indications in Phase 1 9 New Molecular Entity Pfizer Pipeline – October 31, 2017 (cont’d) Therapeutic Area Compound Name Mechanism of Action Indication Phase Phosphatidyl inositol-3 kinase catalytic sub-unit α inhibitor / gedatolisib (PF-05212384) Cancer Phase 1 mammalian target of rapamycin inhibitor (PI3K/mTOR) CCR2 (Chemokine receptor 2) PF-04136309 Pancreatic Cancer Phase 1 Antagonist PF-04518600 OX40 receptor Agonist Cancer (Biologic) Phase 1 protein tyrosine kinase 7 (PTK7) PF-06647020 Cancer (Biologic) Phase 1 Targeted
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