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DOS RR Full 2005.Pdf Carlos A. Pellegrini, M.D. The Henry N. Harkins Professor and Chairman non-profit org. u.s. postage University of Washington p a i d Department of Surgery seattle, wa Box 356410 permit no. 62 Seattle, WA 98195-6410 2 0 0 5 0 0 2 university of washington school of medicine of school washington of university surgery of department the in research surgery department of surgery research 2 0 0 5 r e p o r t Research in the Department of Surgery University of Washington School of Medicine 2 0 0 5 r e p o r t university of washington department of surgery box 356410 seattle, wa 98195-6410 chairman: carlos a. pellegrini, m.d. editor: alexander w. clowes, m.d. associate editor: siobhan brown managing editor: eileen herman Additional copies of this publication may be obtained by calling Eileen Herman at (206) 523-6841, [email protected] cover photos: dan lamont, photodisc 1 2 table of contents report from the chairman .......................................... 4 reports grouped by division Cardiothoracic Surgery ................................................................ 7 HMC/Trauma Surgery ............................................................... 21 Pediatric Surgery ......................................................................... 63 Plastic and Reconstructive Surgery ............................................ 67 Transplant Service ...................................................................... 81 UWMC/General Surgery .......................................................... 91 VAPSHCS/General Surgery .................................................... 115 Vascular Surgery ........................................................................ 123 individual investigators Aldea, Gabriel S. M.D. ................................................................ 8 Anderson, Benjamin O. M.D. .................................................. 92 Beach, Kirk W. M.D., Ph.D. .................................................. 124 Bulger, Eileen M.D. ................................................................... 22 Clowes, Alexander W. M.D. .................................................... 129 Cuschieri, Joseph M.D. ............................................................. 26 Daum, Gunter Ph.D. ............................................................... 132 Engrav, Loren M.D. ................................................................... 68 Flum, David R. M.D., MPH ..................................................... 95 Gibran, Nicole M.D. .................................................................. 29 Hatsukami, Thomas M.D. ...................................................... 135 Hocking, Anne Ph.D. ................................................................ 76 Hopper, Richard A. M.D., M.S. .............................................. 73 Horvath, Karen D. M.D. ........................................................... 99 Isik, F. Frank M.D. ..................................................................... 76 Jurkovich, Gregory J. M.D. ....................................................... 32 Karmy-Jones, Riyad M.D. ......................................................... 11 Kohler, Ted R. M.D. ................................................................ 140 Kuhr, Christian S. M.D. ........................................................... 82 Langdale, Lorrie M.D. ............................................................ 116 Leotta, Daniel F. Ph.D. ........................................................... 143 Li, Wei M.D., Ph.D. ................................................................... 84 Maier, Ronald V. M.D. .............................................................. 36 Mock, Charles M.D., Ph.D. ...................................................... 41 Mulligan, Michael S. M.D. ....................................................... 14 Nathens, Avery M.D., Ph.D., MPH .......................................... 50 Oelschlager, Brant K. M.D. .................................................... 102 O’Keefe, Grant M.D., MPH ..................................................... 55 Pellegrini, Carlos A. M.D. ...................................................... 102 Perkins, James D. M.D. ............................................................. 87 Satava, Richard M.D. ............................................................... 107 Sawin, Robert S. M.D. ............................................................... 64 Sinanan, Mika M.D., Ph.D. .................................................... 109 Sobel, Michael M.D. ................................................................ 120 Verrier, Edward D. M.D. ........................................................... 17 Waldhausen, John M.D. ............................................................ 65 Winn, Robert K. Ph.D. ............................................................. 59 Yeung, Raymond S. M.D. ........................................................ 112 3 report from the chairman Clinical Treatment Begins in the Research Laboratory Medical research unravels the mysteries of life and helps Nevertheless, research possibilities do not exist in us understand how even the smallest components of the a vacuum. Technological advances offer choices and body work and how the body reacts to the environment. demand decisions that were unheard of only a few years However important that is, research really “hits home” ago; at the same time, fewer dollars are available to when its findings can be applied directly to improve our support such services. Societal pressures have led us ability in preventing, diagnosing, or curing disease and, more and more into the field of quality of care, which is thus, directly helping people improve their lives. This broadly defined as doing what is right for the right is frequently referred to as translational research — the individual at the right time and within the economic clinical application of new knowledge. Certainly there is constraints of society. Consequently, we are actively no specific line separating basic science research from involved in the emerging field of outcomes research. translational research as, by its very nature, basic science This discipline addresses the impact of surgery on an research eventually provides the foundation for the individual’s life and on society as a whole. It paints an translation into clinical applications. The scientific overview that helps the surgeon and patient determine community holds our department investigators’ what should be done instead of what could be done. A research in high regard and I can easily point to an valuable tool when used properly, outcomes research impressive array of credentials, honors, awards, and ensures that investigative endeavors continue to provide peer-reviewed funding sources as testimony of this the very best in comprehensive patient care. Under esteem. Yet the real reason I know that our work matters David Flum’s leadership our department is developing a is because I see and hear from the people whose lives major center dedicated to Outcomes Research which have been transformed because of it. Their stories should be fully developed by mid 2005. confirm that our work makes a difference. Above all, our primary mission is to provide you The benefits of research are most obvious and and your loved ones with the very best in surgical care. valuable in those areas of life over which we have no I invite you to learn how traumatic injury and other control. For example, we are all getting older and it is a illnesses will be treated tomorrow by reading this report well-documented fact that the incidence of vascular in which our faculty explain some of their ground- disease increases with age. The intimate pathophysiology breaking studies. Our investigators are listed in alpha- of atherosclerosis, the formation and evolution of betical order by division to make it easier for you to plaque, and the natural history of revascularization are locate either a particular individual or specialty. If you processes that have been studied for years by our vascular are interested in supporting our efforts to discover surgeons. They have found many answers which have tomorrow’s cures, please contact Eileen Herman, Public brought substantial acknowledgment to this group from Information Specialist, at (206) 522-7076, email: within and outside of the University of Washington. [email protected]. More recently, they have been recognized by their integration into a major vascular research initiative at the new UW research campus. This state-of-the-art facility concentrates all the UW’s research expertise in vascular disease in one location at South Lake Union. These new arrangements will foster greater interdisci- plinary collaboration and benefit the aging patient Carlos A. Pellegrini population with innovative treatment protocols. The Henry N. Harkins Professor and Chairman 4 research honors & awards alexander w. clowes, m.d., chief, division of vascular kimberly riehle, m.d.; (then) r3: awarded a two-year, surgery: winner of The Sheen Award. Nominated by the $30,000 American College of Surgeons research scholar- American College of Surgeons and reviewed by a committee ship for work entitled, “Liver Regeneration in SOCS-3 of physicians from Atlantic County, NJ, this illustrious Knockout Mice.” Dr. Riehle will work in the laboratory of award honors doctors who have made outstanding contri- Dr. Nelson Fausto, Professor & Chairman of the Department butions to mankind through the fields
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