Targeting Iron Homeostasis Induces Cellular Differentiation and Synergizes with Differentiating Agents in Acute Myeloid Leukemia
Article Targeting iron homeostasis induces cellular differentiation and synergizes with differentiating agents in acute myeloid leukemia Celine Callens,1,2 Séverine Coulon,1,2 Jerome Naudin,1,2,3,4 Isabelle Radford-Weiss,2,5 Nicolas Boissel,4,9 Emmanuel Raffoux,4,9 Pamella Huey Mei Wang,3,4 Saurabh Agarwal,3,4 Houda Tamouza,3,4 Etienne Paubelle,1,2 Vahid Asnafi,1,2,6 Jean-Antoine Ribeil,1,2 Philippe Dessen,10 Danielle Canioni,2,7 Olivia Chandesris,2,8 Marie Therese Rubio,2,8 Carole Beaumont,4,11 Marc Benhamou,3,4 Hervé Dombret,4,9 Elizabeth Macintyre,1,2,6 Renato C. Monteiro,3,4 Ivan C. Moura,3,4 and Olivier Hermine1,2,8 1Centre National de la Recherche Scientifique UMR 8147, Paris 75015, France 2Faculté de Médecine, Université René Descartes Paris V, Institut Fédératif Necker, Paris 75015, France 3Institut National de la Santé et de la Recherche Médicale (INSERM), U699, Paris 75018, France 4Faculté de Médecine, Université Denis Diderot Paris VII, Paris 75018, France 5Laboratoire de cytogénétique, 6Laboratoire d’Hématologie, 7Service d’Anatomo-Pathologie, and 8Service d’Hématologie, Hôpital Necker-Enfants Malades, Assistance Publique Hôpitaux de Paris (AP-HP), Paris 75015, France 9Service d’Hématologie, Hôpital Saint-Louis, AP-HP, Paris 75010, France 10Unité de Génomique Fonctionnelle, Institut Gustave Roussy, Villejuif 94800, France 11INSERM U773, Centre de Recherche Biomédicale Bichat Beaujon CRB3, Paris 75018, France Differentiating agents have been proposed to overcome the impaired cellular differentia- tion in acute myeloid leukemia (AML). However, only the combinations of all-trans retinoic acid or arsenic trioxide with chemotherapy have been successful, and only in treating acute promyelocytic leukemia (also called AML3).
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