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www.biovision.com Nibs: Protein Kinase Inhibitors Kinase Protein Nibs: formats. >120 structurally diverse “nibs” for research. Many of these nibs are also available as “ready-to-use” “EZSolution” angiogenesis inhibitors, and “rafenib” for rapidly accelerated fibrosarcomakinase (RAF) inhibitors. BioVision offers specifically,“tinib” tyrosine is kinase forused inhibitors, “anib” for (“nib” is verbal shorthand More of for kinase “inhibit”) enzymes. in their names. suffix The “nib” indicates a small-molecule inhibitor inhibitors as drugs. the 52 Of approved drugs, 43 have suffix “nib” So far,enzymes. the U.S. FDA has approved >52 Protein kinase madebeen in developing drugs against protein kinase family of Over the past 20enzymes. years, tremendous progress has due to mutations, overexpression, and dysregulation of these because of their key roles in the pathogenesis of many illnesses targets in oncology and drug discovery in today’s research Protein kinases are one of the most important categories of Toll Free: 800-891-9699 (US Only) Toll Free: 800-891-9699 F:T: 408-493-1801 408-493-1800 CA 95035 Blvd, Milpitas, 155 Milpitas S. Product Name Product Branebrutinib (SKI-606) (MEK-162) Belizatinib (TSR-011) phosphateBaricitinib EZSolution™ Baricitinib (AG-013736) Avitinib , Free base Apatinib Mesylate Anlotinib, Free base Amuvatinib Altiratinib Alpelisib Alofanib Allitinib (CH5424802) hydrochlorideAfuresertib (BIBW2992) Cat. No. Cat. B2999 B1613 B1608 B2156 B1271 B3009 B3002 B1848 B1193 B2998 B2028 B2480 B2995 1584 2254 2841 2842 1581 9458 9563 2867 1616 Size 5 mg, 25mg 1mg, 5mg 5 mg, 25mg 5 mg, 25mg 5 mg, 25mg 10 mg, 50mg 5 mg 10 mg, 50mg 5 mg, 25mg 5mg, 25mg 1mg, 5mg 5 mg, 25mg 5 mg, 25mg 5 mg, 25mg 5 mg, 25mg 5 mg, 25mg 5 mg, 25mg 5mg, 25mg 1mg, 5mg 5 mg, 25mg 5 mg, 25mg 1 mg, 5mg CAS. No.CAS. 1420477-60-6 1912445-55-6 380843-75-4 606143-89-9 1357920-84-3 1187595-84-1 1187594-09-7 1187594-09-7 319460-85-0 1557267-42-1 1703793-34-3 811803-05-1 1218779-75-9 1058156-90-3 850879-09-3 1345847-93-9 1217486-61-7 1612888-66-0 897383-62-9 1256580-46-7 1047645-82-8 439081-18-2 Known Targets Bruton's (BTK) Bruton's tyrosine kinase Bruton's tyrosine kinase (BTK) Bruton's tyrosine kinase BCR-Abl, Src, Lyn, Hck MEK1/2 and TRKC TRKB, TRKA, ALK, JAK1/2 JAK1/2 JAK1/2 VEGFR1/2/3, PDGFRβ EGFR mutations oncogenic KITandPDGFRA VEGFR2 VEGFR2 VEGFR, FGFR,PDGFR forms ofc-KIT, PDGFR&FLT3 c-MET, andthemutant c-RET and TRK MET,VEGFR2 TIE2, PI3-K FGFR2 andEGFR ErbB2 ALK andRET AKT ErbB4 EGFR, ErbB2, Product Name Cat. No. Size CAS. No. Known Targets (AP26113) 9675 5 mg, 25 mg 1197953-54-0 ALK, ROS1, IGF-1R, Flt3, EGFR Brigatinib Analog B2025 5 mg, 25 mg 1197958-12-5 ALK Brivanib B1325 1 mg, 5 mg 649735-46-6 VEGFR and FGFR Brivanib Alaninate B1326 1 mg, 5 mg 649735-63-7 VEGFR and FGFR dihydrochloride(CI-1033, 1617 5 mg, 25 mg 289499-45-2 EGFR and ErbB2 PD-183805) B3005 5mg, 25mg 1029712-80-8 c-MET kinase RET, Met, VEGFR1/2/3, Kit, Carbozantinib 1935 5 mg, 25 mg 849217-68-1 TrkB, Flt3, Axl, Tie2, ROS1 (AZD2171) 1613 1 mg, 5 mg 288383-20-0 VEGFR and c-Kit (LDK-378) B1928 5 mg, 25 mg 1032900-25-6 ALK, IGF-1R, InsR, ROS1 B1689 5 mg, 25 mg 934660-93-2 MEK1/2 EZSolution™ Cobimetinib B2489 5 mg 934660-93-2 MEK1/2 9679 5 mg, 25 mg 670220-88-9 FLT3 EZSolution™ Creolanib B2626 5 mg 670220-88-9 FLT3 ALK, c-Met (HGFR), ROS1, 1934 5 mg, 25 mg 877399-52-5 MST1R mesylate 2800 5 mg, 25 mg 1195768-06-9 B-Raf (GSK-2118436 mesylate) (PF299804) 2678 5 mg, 25 mg 1110813-31-4 EGFR/ErbB2/ErbB4 BCR-Abl, EGFR, Src, Lck, Yes, EZSolution™ 2029 25 mg 302962-49-8 Fyn, Kit, EphA2, PDGFRβ BCR-Abl, EGFR, Src, Lck, Yes, Dasatinib (BMS-354825, Spryel) 1586 25 mg, 100 mg 302962-49-8 Fyn, Kit, EphA2, PDGFRβ Derazantinib B2222 1 mg, 5 mg 1234356-69-4 FGFR Desmethyl (OSI-420) B2201 1 mg, 5 mg 183320-51-6 EGFR FLT3/c-Kit, FGFR1/3, VEG- Dovintinib Lactate B1615 5 mg, 25 mg 915769-50-5 FR1-4) FLT3/c-Kit, FGFR1/3, VEG- Dovitinib B1614 5 mg, 25 mg 405169-16-6 FR1-4) Dubermatinib (TP-0903) 9590 5 mg, 25 mg 1341200-45-0 AXL Encorafeinb B2103 5 mg, 25 mg 1269440-17-6 B-RafV600E/K Ensartinib B1946 5 mg, 25 mg 1365267-27-1 ALK ROS1+ NSCLC; solid tumors B1324 5 mg, 25 mg 1108743-60-7 with NTRK fusion proteins B2458 5 mg, 25 mg 1346242-81-6 FGFR1/2/3/4 Erdafitinib B2458 5 mg, 25 mg 1346242-81-6 FGFR1/2/3/4 Erlotinib hydrochloride 1588 100 mg, 1 g 183319-69-9 EGFR Erlotinib, Free base 2048 100 mg, 1 g 183321-74-6 EGFR Evobrutinib B2379 5 mg, 25 mg 1415823-73-2 Bruton’s tyrosine kinase (BTK) (TG101348) 2314 1 mg, 5 mg 936091-26-8 JAK2 EZSolution™ Fedratinib B2487 5 mg 936091-26-8 JAK2 (TG101348) Fenebrutinib (GDC-0853) B2074 5 mg, 25 mg 1434048-34-6 Bruton’s tyrosine kinase (BTK) 9476 5 mg, 25 mg 849217-64-7 c-Met and VEGFR2 www.biovision.com www.biovision.com Fostamatinib disodium 1936 1 mg, 5 mg 1025687-58-4 Syk, Spleen tyrosine kinase Fruquintinib B1979 5 mg, 25 mg 1194506-26-7 VEGFR1/2/3 2 Product Name Cat. No. Size CAS. No. Known Targets 1589 5 mg, 25 mg 184475-35-2 EGFR EZSolution™ Gefitinib 2030 5 mg 184475-35-2 EGFR B1294 5 mg, 25 mg 1254053-43-4 FLT3 Glumetinib B2561 5 mg, 25 mg 1642581-63-2 c-Met Golvatinib 2655 5 mg, 25 mg 928037-13-2 c-Met and VEGFR2 Bruton's tyrosine kinase (PCI-32675) 2298 5 mg, 25 mg 936563-96-1 (BTK) B3003 5mg, 25mg 610798-31-7 EGFR Idealisib (CAL-101) 2613 5 mg, 25 mg 870281-82-6 PI3K catalytic subunit p110δ Mesylate (CGP-57148B, 1625 100 mg, 1 g 220127-57-1 BCR-Abl, Kit, PDGFR STI-571) Imatinib, Free base 2141 100 mg, 1 g 152459-95-5 BCR-Abl, Kit, PDGFR Ditosylate 1624 25 mg, 100 mg 388082-78-8 EGFR, ErbB2 EZSolution™ Lapatinib Ditosylate 2807 10 mg 388082-78-8 EGFR, ErbB2 Lapatinib, Free base 2138 25 mg, 100 mg 231277-92-2 EGFR, ErbB2 (LOXO-101) B2291 5 mg, 25 mg 1223403-58-4 TRKA/B/C Larotrectinib (Sulfate) (LOXO-101 B2545 5 mg, 25 mg 1223405-08-0 TRKA/B/C sulfate) Lazertinib B2348 5 mg, 25 mg 1903008-80-9 EGFR VEGFRs, FGFRs, PDGFR, Kit, B1157 5 mg, 25 mg 417716-92-8 RET 1805 500 µg, 1 mg 111358-88-4 FLT3, JAK2, and TrkA Linifanib (ABT-869) 1615 1 mg, 5 mg 796967-16-3 VEGFR and PDGFR , Free base 2294 5 mg, 25 mg 867160-71-2 IGF-1R and InsR (PF0643922) B1169 10 mg, 50 mg 1454846-35-5 ALK 2007 5 mg, 25 mg 790299-79-5 c-KIT, PDGF and FGFR Merestinib B3007 1mg, 5mg 1206799-15-6 MET 2022 5 mg, 25 mg 453562-69-1 VEGFR1/2/3 and PDGFR Motesanib diphosphate B2196 5 mg, 25 mg 857876-30-3 VEGFR1/2/3 and PDGFR (TAK-165) 1961 1 mg, 5 mg 1086062-66-9 PI3-K Naquotinib B1317 5 mg, 25 mg 448232-80-1 EGFR T790M Nazartinib B2288 5 mg, 25 mg 1508250-71-2 EGFR T790M 2023 5 mg, 25 mg 698387-09-6 ErbB2/HER2 1750 25 mg, 100 mg 641571-10-0 BCR-Abl, PDGFR, DDR1 FGFR1/2/3, PDGFRα/β, VEG- (BIBF1120) 2167 5 mg, 25 mg 656247-17-5 FR1/2/3, Flt3 B1218 5 mg, 25 mg 1353550-13-6 EGFR T790M (AZD-9291) 2674 5 mg, 25 mg 1421373-65-0 EGFR T790M EZSolution™ Osimertinib B2490 5 mg 1421373-65-0 EGFR T790M (AZD-9291) Osimertinib (Mesylate) (AZD-9291 B1899 5 mg 1421373-66-1 EGFR T790M Mesylate) (SB1518) 2450 1 mg, 5 mg 937272-79-2 EGFR T790M EZSolution™ Pacritinib (SB1518) B2485 1 mg 937272-79-2 EGFR T790M

www.biovision.com VEGFR1/2/3, PDGFRα/β, (GW-786034) 1916 5 mg, 25 mg 444731-52-6 FGFR1/3, Kit, Lck, Fms, Itk Pelitinib (EKB-569) 2676 5 mg, 25 mg 257933-82-7 EGFR 2 3 Product Name Cat. No. Size CAS. No. Known Targets (PLX-3397) 9617 10 mg, 50 mg 1029044-16-3 CSFR1/Kit Pexmetinib B1711 5 mg, 25 mg 945614-12-0 MAPK and Tie2/Tek BCR-Abl, BCR-Abl T315I, VEGFR, PDGFR, FGFR, EphR, 2712 50 mg, 10 mg 943319-70-8 Src family kinases, Kit, RET, Tie2, Flt3 Poziotinib 9519 10 mg, 50 mg 1092364-38-9 HER1, HER2, and HER4 2008 1 mg, 5 mg 950769-58-1 FLT3 VEGFR1/2/3, BCR-Abl, B-Raf, 2891 5 mg, 25 mg 755037-03-7 B-Raf(V600E), Kit, PDGFRα/β, RET, FGFR1/2, Tie2, Eph2A VEGFR1/2/3, BCR-Abl, B-Raf, Regorafenib monohydrate B1621 5 mg, 25 mg 1019206-88-2 B-Raf(V600E), Kit, PDGFRα/β, RET, FGFR1/2, Tie2, Eph2A Repotrectinib (TPX-0005) B2027 5 mg, 25 mg 2058227-19-1 ALK Roblitinib B3008 1mg, 5mg 1708971-55-4 FGFR4 (CO-1686) 2794 5 mg, 25 mg 1374640-70-6 EGFRL858R/T790M EZSolution™ B2477 5 mg 941678-49-5 JAK1/2 Ruxolitinib Phosphate B2631 5 mg, 25 mg 1092939-17-7 JAK1/2 Ruxolitinib, Free base 2139 5 mg, 25 mg 941678-49-5 JAK1/2 EGFR (ErbB-1), Neu (ErbB-2) Sapitinib (AZD-8931) 9659 5 mg, 25 mg 848942-61-0 and ErbB-3 EZSolution™ Saracatinib B2625 5 mg 379231-04-6 c-Src and Bcr-ABL Saracatinib (AZD-0530) 1582 5 mg, 25 mg 379231-04-6 c-Src and Bcr-ABL B3006 1mg, 5mg 1313725-88-0 c-MET B2996 1mg, 5mg 2152628-33-4 RET Kinase 9491 5 mg 204005-46-9 VEGFR2 EZSolution™ Semaxanib 9492 5 mg 204005-46-9 VEGFR2 Axl, MER, VEGFR3, VEGFR2, Sitravatinib B2539 5 mg, 25 mg 1123837-84-2 VEGFR1, KIT , FLT3, DDR2, DDR1, TRKA, TRKB B/C-Raf, B-Raf (V600E), (BAY 43-9006), Free 2142 25 mg, 100 mg 284461-73-0 Kit, Flt3, RET, VEGFR1/2/3, base PDGFRβ B/C-Raf, B-Raf (V600E), Sorafenib Tosylate 1594 25 mg, 100 mg 475207-59-1 Kit, Flt3, RET, VEGFR1/2/3, PDGFRβ B/C-Raf, B-Raf (V600E), EZSolution™ Sorafenib(Tosylate) 2031 25 mg 475207-59-1 Kit, Flt3, RET, VEGFR1/2/3, PDGFRβ PDGFRα/β, VEGFR1/2/3, Kit, EZSolution™ Malate 1804 25 mg 341031-54-7 Flt3, CSF-1R, RET 25 mg, 100 mg, PDGFRα/β, VEGFR1/2/3, Kit, Sunitinib, Free base 2097 557795-19-4 1 g Flt3, CSF-1R, RET PDGFRα/β, VEGFR1/2/3, Kit, Sunitinib, Malate (Sutent) 1611 25 mg, 100 mg 341031-54-7 Flt3, CSF-1R, RET Tandutinib 2024 5 mg, 25 mg 387867-13-2 FLT kinase, PDGFRβ and c-Kit EZSolution™ Tandutinib B2627 5 mg 387867-13-2 FLT kinase, PDGFRβ and c-Kit www.biovision.com www.biovision.com

4 Product Name Cat. No. Size CAS. No. Known Targets VEGFR2, VEGFR3, PDGFα, Telatinib B2054 5 mg, 25 mg 332012-40-5 and c-Kit Theliatinib B3004 1mg, 5mg 1353644-70-8 EGFR Tirabrutinib hydrochlolride B2556 5 mg, 25 mg 1439901-97-9 Bruton's Tyrosine Kinase (BTK) B1546 5 mg, 25 mg 905854-02-6 c-Met VEGFR-1, VEGFR-2, and B1545 5 mg, 25 mg 475108-18-0 VEGFR-3 B1542 5 mg, 25 mg 356068-94-5 VEGFR, FGFR, PDGFR, and Kit Tofacitinib (CP-690550) 1622 5 mg, 25 mg 477600-75-2 JAK1/3 EZSolution™ Tofacitinib B2478 5 mg 477600-75-2 JAK1/3 (CP-690550) Tofacitinib (CP-690550) citrate 9428 5 mg, 25 mg 540737-29-9 JAK1/3 (GSK-1120212) 1960 1 mg, 5 mg 871700-17-3 MEK1/2 B3025 5 mg, 25 mg 937263-43-9 ErbB2 (HER2) EZSolution™ B2486 5 mg 1310726-60-3 JAK1 Upadacitinib (ABT-494) B1947 5 mg, 25 mg 1310726-60-3 JAK1 EGFRs, VEGFRs, RET, Brk, Tie2, 1751 25 mg, 100 mg 443913-73-3 EphRs, Src family kinases EGFR (ErbB-1) and Her-2/neu Varlitinib 2656 5 mg, 25 mg 845272-21-1 (ErbB-2 Vatalanib, dihydrochloride 2025 5 mg, 25 mg 212141-51-0 VEGFR1/2 Vatalanib, Free base 2026 5 mg, 25 mg 212141-54-3 VEGFR1/2 1029872-54-5, A/B/C-Raf, B-Raf (V600E), (PLX-4032) 2235 5 mg, 25 mg 918504-65-1 SRMS, ACK1, MAP4K5, FGR B2512 1 mg, 5 mg 1691249-45-2 Bruton's tyrosine kinase (BTK)

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