Environmental Factors Affecting Thyroid-Stimulating Hormone and Thyroid Hormone Levels
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Assessment of Iodine Deficiency Disorders and Monitoring Their Elimination
Assessment of iodine deficiency disorders and monitoring their elimination A GUIDE FOR PROGRAMME MANAGERS Third edition Assessment of iodine deficiency disorders and monitoring their elimination A GUIDE FOR PROGRAMME MANAGERS Third edition WHO Library Cataloguing-in-Publication Data Assessment of iodine deficiency disorders and monitoring their elimination : a guide for programme managers. – 3rd ed. 1.Iodine – deficiency. 2.Nutrition disorders – prevention and control. 3.Sodium chloride, Dietary – therapeutic use. 4.Nutrition assessment. 5.Nutrition policy – standards. 6.Guidelines. I.World Health Organization. ISBN 978 92 4 159582 7 (NLM classification: WK 250) This report contains the collective views of an international group of experts, and does not necessarily represent the decisions or the stated policy of the World Health Organization. © World Health Organization 2007 All rights reserved. Publications of the World Health Organization can be obtained from WHO Press, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland (tel.: +41 22 791 3264; fax: +41 22 791 4857; e-mail: [email protected]). Requests for permission to reproduce or translate WHO publications – whether for sale or for noncom- mercial distribution – should be addressed to WHO Press, at the above address (fax: +41 22 791 4806; e-mail: [email protected]). The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organi- zation concerning the legal status of any country, territory, city or area or of its authori- ties, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate border lines for which there may not yet be full agreement. -
Analytical Standards for Human Exposure Analysis
ENVIRONMENTAL STANDARDS Cambridge Isotope Laboratories, Inc. isotope.com Analytical Standards for Human Exposure Analysis Human Personal Care Industrial Products Pollution Dermal Inhalation Ingestion Food Tobacco Products Drinking Water Pharmaceuticals Cambridge Isotope Laboratories, Inc. North America: 1.800.322.1174 [email protected] | International: +1.978.749.8000 [email protected] | fax: 1.978.749.2768 | isotope.com Cambridge Isotope Laboratories, Inc. | Analytical Standards for Human Exposure Analysis Analytical Standards for Human Exposure Analysis Exposomics is the study of the exposome and is a field that has been gaining attention as researchers focus not only on identifying contaminants present in the environment, but their effects on humans. The exposome encompasses an individual’s lifetime exposure to internal and external stresses, including environmental, dietary, and metabolic factors, to name a few. Cambridge Isotope Laboratories, Inc. (CIL) has and continues to produce standards that are used in many leading biomonitoring research projects, such as the US Centers for Disease Control and Prevention (CDC) “National Health and Nutrition Examination Survey (NHANES)” and the Japan National Institute for Environmental Studies (NIES) “Japan Environment and Children’s Study (JECS).” The CDC’s NHANES program is focused on assessing the health and nutritional status of both children and adults in the United States. There are several studies involved in this program, which is notable in that both interviews and physical examinations are factored in when compiling data. The first NHANES study was conducted from 1971-1975 and subsequent studies are continuing to this day. Additional information about the NHANES program can be found at www.cdc.gov/nchs/nhanes/index.htm. -
Thyroid Hormones in Fetal Growth and Prepartum Maturation
A J FORHEAD and A L FOWDEN Thyroid hormones and fetal 221:3 R87–R103 Review development Thyroid hormones in fetal growth and prepartum maturation A J Forhead1,2 and A L Fowden1 Correspondence should be addressed 1Department of Physiology, Development and Neuroscience, University of Cambridge, Physiology Building, to A L Fowden Downing Street, Cambridge CB2 3EG, UK Email 2Department of Biological and Medical Sciences, Oxford Brookes University, Oxford OX3 0BP, UK [email protected] Abstract The thyroid hormones, thyroxine (T4) and triiodothyronine (T3), are essential for normal Key Words growth and development of the fetus. Their bioavailability in utero depends on " thyroid hormones development of the fetal hypothalamic–pituitary–thyroid gland axis and the abundance " intrauterine growth of thyroid hormone transporters and deiodinases that influence tissue levels of bioactive " maturation hormone. Fetal T4 and T3 concentrations are also affected by gestational age, nutritional and " neonatal adaptation endocrine conditions in utero, and placental permeability to maternal thyroid hormones, which varies among species with placental morphology. Thyroid hormones are required for the general accretion of fetal mass and to trigger discrete developmental events in the fetal brain and somatic tissues from early in gestation. They also promote terminal differentiation of fetal tissues closer to term and are important in mediating the prepartum maturational effects of the glucocorticoids that ensure neonatal viability. Thyroid hormones act directly through anabolic effects on fetal metabolism and the stimulation of fetal oxygen Journal of Endocrinology consumption. They also act indirectly by controlling the bioavailability and effectiveness of other hormones and growth factors that influence fetal development such as the catecholamines and insulin-like growth factors (IGFs). -
Priority Pollutant, Endocrine Disruptor, and Chemical Contaminant Standards Solutions for a Greener World Introduction
Priority Pollutant, Endocrine Disruptor, and Chemical Contaminant Standards Solutions for a Greener World Introduction Priority Pollutant, Endocrine Disruptor, and Chemical Contaminant Standards isotope.com Pharmaceutical and Personal Care Product Halogenated and Substituted Benzene Standards and Phenol Standards Concern about environmental and human exposure to Many industrial and consumer products are composed of pharmaceuticals and personal care products (PPCPs) has grown chemicals that contain halogenated or substituted benzene significantly. This classification encompasses a broad range of or phenol functional groups. Resistant to decomposition and chemicals, ranging from antibiotics to hormones to pesticides. metabolism, these chemicals may persist even after the parent One common theme among these groups is the need for molecule has undergone partial decomposition, or they may high-quality isotopically labeled standards to strengthen the exist as a product or an industrial byproduct. The increased analysis of PPCPs in difficult matrices such as sewage sludge use of brominated compounds is expected to lead to more and wastewater. CIL, with guidance from leading laboratories brominated benzenes and phenols in the environment, and around the world, works diligently to produce representative the continued presence of chlorinated compounds ensures standards for the analysis of PPCPs. that chlorinated benzenes and phenols will be found in the environment for years to come. Food and Drinking Water Analysis Standards Bisphenol Standards Increased attention to possible contamination of food and Bisphenol A (BPA) is a synthetic compound that has long been water has caused analysts to broaden the scope of trace food used in the production of polycarbonate plastics and epoxy and water testing by IDMS. -
Metabolism of Reverse Triiodothyronine by Isolated Rat Hepatocytes
Metabolism of reverse triiodothyronine by isolated rat hepatocytes. S J Rooda, … , M A van Loon, T J Visser J Clin Invest. 1987;79(6):1740-1748. https://doi.org/10.1172/JCI113014. Research Article Reverse triiodothyronine (rT3) is metabolized predominantly by outer ring deiodination to 3,3'-diiodothyronine (3,3'-T2) in the liver. Metabolism of rT3 and 3,3'-T2 by isolated rat hepatocytes was analyzed by Sephadex LH-20 chromatography, high performance liquid chromatography, and radioimmunoassay, with closely agreeing results. Deiodinase activity was inhibited with propylthiouracil (PTU) and sulfotransferase activity by sulfate depletion or addition of salicylamide or dichloronitrophenol. Normally, little 3,3'-T2 production from rT3 was observed, and 125I- was the main product of both 3, [3'-125I]T2 and [3',5'-125I]rT3. PTU inhibited rT3 metabolism but did not affect 3,3'-T2 clearance as explained by accumulation of 3,3'-T2 sulfate. Inhibition of sulfation did not affect rT3 clearance but 3,3'-T2 metabolism was greatly diminished. The decrease in I- formation from rT3 was compensated by an increased recovery of 3,3'-T2 up to 70% of rT3 metabolized. In conclusion, significant production of 3,3'-T2 from rT3 by rat hepatocytes is only observed if further sulfation is inhibited. Find the latest version: https://jci.me/113014/pdf Metabolism of Reverse Triiodothyronine by Isolated Rat Hepatocytes Sebo Jan Eelkman Rooda, Maria A. C. van Loon, and Thoo J. Vissef Department ofInternal Medicine III and Clinical Endocrinology, Erasmus University Medical School, Rotterdam, The Netherlands Abstract It deiodinates only the outer ring of substrates such as T4 and rT3 (2-4). -
Early Effects of Iodine Deficiency on Radial Glial Cells of the Hippocampus of the Rat Fetus
Early effects of iodine deficiency on radial glial cells of the hippocampus of the rat fetus. A model of neurological cretinism. J R Martínez-Galán, … , G Morreale de Escobar, A Ruiz-Marcos J Clin Invest. 1997;99(11):2701-2709. https://doi.org/10.1172/JCI119459. Research Article The most severe brain damage associated with thyroid dysfunction during development is observed in neurological cretins from areas with marked iodine deficiency. The damage is irreversible by birth and related to maternal hypothyroxinemia before mid gestation. However, direct evidence of this etiopathogenic mechanism is lacking. Rats were fed diets with a very low iodine content (LID), or LID supplemented with KI. Other rats were fed the breeding diet with a normal iodine content plus a goitrogen, methimazole (MMI). The concentrations of -thyroxine (T4) and 3,5,3'triiodo-- thyronine (T3) were determined in the brain of 21-d-old fetuses. The proportion of radial glial cell fibers expressing nestin and glial fibrillary acidic protein was determined in the CA1 region of the hippocampus. T4 and T3 were decreased in the brain of the LID and MMI fetuses, as compared to their respective controls. The number of immature glial cell fibers, expressing nestin, was not affected, but the proportion of mature glial cell fibers, expressing glial fibrillary acidic protein, was significantly decreased by both LID and MMI treatment of the dams. These results show impaired maturation of cells involved in neuronal migration in the hippocampus, a region known to be affected in cretinism, at a stage of development equivalent to mid gestation in humans. -
United States Patent (10) Patent N0.: US 7,288,257 B2 Powell (45) Date of Patent: Oct
US007288257B2 (12) United States Patent (10) Patent N0.: US 7,288,257 B2 Powell (45) Date of Patent: Oct. 30, 2007 (54) DIAGNOSIS AND TREATMENT OF HUMAN 5,342,788 A 8/1994 Kunst et a1. .............. .. 436/500 DORMANCY SYNDROME 5,691,456 A 11/1997 AdamcZyk et al. ....... .. 530/405 6,087,090 A 7/2000 Mascarenhas ................ .. 435/4 (76) Inventor: Michael Powell, 150 Catherine Lance, 2003/0007941 A1 1/2003 Cornelius et a1, Suite 1, Grass Valley, CA (US) 95945 ( * ) Notice: Subject to any disclaimer, the term of this patent is extended or adjusted under 35 OTHER PUBLICATIONS U.S.C. 154(b) by 199 days. _ Hannah V. Carey, The American Physiological Society, Physical _ Rev 83; Mammalian Hibernation: Cellular and Molecular (21) Appl' NO" 10/444’845 Responses to Depressed Metabolism and Low Temperature, 2003, (22) Filed: May 23, 2003 PP' 1153'1181' _ _ _ Primary ExamineriRuth A Davis (65) Pnor Pubhcatlon Data (74) Attorney, Agent, or F irmiBorson LaW Group, PC; D. US 2003/0228628 A1 Dec. 11, 2003 Benjamin Borson Related US. Application Data (57) ABSTRACT (60) Provisional application No. 60/382,913, ?led on May $112002’ provlslonal apphcanon NO‘ 60/383’271’ New methods for diagnosis of human dormancy syndrome e on May 24’ 2002' are provided. Human dormancy syndrome is characterized (51) Int C1 by elevated serum ratio of rT3/iT 3 compared to a population 1462K 3'9/00 (2006 01) of normal subjects from Which subjects suffering from A 61K 38/22 (200601) ?bromyalgia, chronic fatigue, obesity, dementias including A 61K 38/27 (200601) AlZheimer’s Disease and related dormancy conditions are C1 2 Q 1/00 (200601) excluded, and the presence of one or more ?ndings related ' A / A / A to reduced activity including torpor, chronic fatigue, insulin (52) US. -
Endocrinology Review – Adrenal and Thyroid Disorders
FOCUS: ENDOCRINOLOGY Endocrinology Review – Adrenal and Thyroid Disorders LINDA S. GORMAN, JANELLE M. CHIASERA LEARNING OBJECTIVES This article represents the first of three articles focusing 1. Define endocrinology and list the major endocrine on the endocrine system. The first article will provide glands of the body. you with fundamental theory regarding the endocrine system that will serve as a basis for understanding the 2. Explain how feedback (positive and negative) Downloaded from promotes maintenance of normal levels of next two articles focusing on two specific endocrine hormones. glands, the thyroid and adrenal glands. 3. Differentiate between steroid and peptide hormones with regard to their mechanism of Endocrinology is the branch of medical science that action. deals with the endocrine system, a system that consists 4. Provide examples of peptide and steroid hormones. of several glands located in different parts of the body http://hwmaint.clsjournal.ascls.org/ 5. Explain how endocrine disorders are categorized. that secrete hormones directly into the bloodstream. Although every organ system in the body may respond ABBREVIATIONS: ACTH - adrenocorticotropic hor- to hormones, endocrinology focuses specifically on mone; ADH - antidiuretic hormone; CRH – cortico- endocrine glands whose primary function is hormone tropin releasing hormone; DHEA – dehydroepian- secretion. Major endocrine glands include the pituitary drosterone; FSH - follicle stimulating hormone; GHRH (anterior and posterior), hypothalamus, thyroid, - growth hormone -
Recommendation on Perfluorinated Compound Treatment Options for Drinking Water
Recommendation on Perfluorinated Compound Treatment Options for Drinking Water New Jersey Drinking Water Quality Institute Treatment Subcommittee June 2015 Laura Cummings, P.E., Chair Anthony Matarazzo Norman Nelson, P.E. Fred Sickels Carol T. Storms Background At the request of the Commissioner of the New Jersey Department of Environmental Protection the Drinking Water Quality Institute (DWQI) is working to develop recommended Maximum Contaminant Levels (MCL) for three long-chain perfluorinated compounds (PFC): Perfluorononanoic acid (PFNA), Perfluorooctanoic acid (PFOA) and Perfluorooctanesulfonic acid (PFOS). The Treatment Subcommittee of the Drinking Water Quality Institute is responsible for identifying available treatment technologies or methods for removal of hazardous contaminants from drinking water. The subcommittee has met several times over the last year beginning in July 2014 to discuss and investigate best available treatment options for the long-chain (8 – 9 carbon) PFCs identified above. The subcommittee decided to research and report on treatment options for all three compounds, as the treatment options are not expected to differ from compound to compound due to their similar properties (e.g. persistence, water solubility, similar structure, strong carbon-fluorine bonds, and high polarity). This approach contrasts with the other two subcommittees which will address the three compounds separately. The subcommittee has gathered and reviewed data from several sources in order to identify widely-accepted and well-performing strategies for removal of long-chain PFCs, including use of alternate sources. This report is intended to present the subcommittee’s findings. At this time, there are no Federal drinking water standards for PFNA, PFOA or PFOS; however in 2009 the United State Environmental Protection Agency (USEPA, 2009) established a Provisional Health Advisory (PHA) level of 0.4 µg/L for PFOA and 0.2 µg/L PHA for PFOS for short-term exposure. -
Comprehensive Thyroid Plus Adrenal Report
Comprehensive Thyroid Plus Adrenal Report Jane Doe SAMPLEDate Collected: 2/13/2017 Comprehensive Thyroid Plus Adrenal Report Patient Name: Doe, Jane Batch Number: B0000 Patient DOB: 12/10/1960 Accession Number: Q00000 Gender: F Date Received: 2/14/2017 Physician Jon Doe, ND Report Date: 2/22/2017 Test Patient Results Reference Value DHEAS µg/dL 0 125 250 375 500 107 35 - 430 TSH µIU/mL 0.020 1.260 2.500 3.740 4.980+ 7.030 0.358 - 3.74 T4, Total µg/dL 0.5 4.4 8.3 12.1 16.0 7.2 4.5 - 12.5 T3, Free pg/mL 0.5 1.9 3.3 4.6 6.0 3.6 2.2 - 4.0 T4, Free ng/dL 0.10 0.83 1.55 2.28 3.00 0.87 0.76 - 1.46 Cortisol µg/dL 0.2 11.4 22.6 33.8 45.0 6.5 3.1 - 22.4 AntiTPO Ab IU/mL 10.0 20.0 30.0 40.0 50.0 + > 1000.0 0.0 - 35.0 AntiThyroglobulin Ab IU/mL 20 30 40 50 60 + 97 ND - 40 Thyroglobulin ng/mL 0 20 40 60 80 38 <= 55 Thyroxinebinding globulin, TBG µg/mL SAMPLE0 11 23 34 45 20 14 - 31 10401 Town Park Drive, Houston, Texas 77072 USA CLIA# 45D0710715 (800)227-LABS(5227) / (713)-621-3101 James W. Jacobson, Ph.D., Laboratory Director Comprehensive Thyroid Plus Adrenal Report Patient Name: Doe, Jane Batch Number: B0000 Patient DOB: 12/10/1960 Accession Number: Q00000 Gender: F Date Received: 2/14/2017 Physician Jon Doe, ND Report Date: 2/22/2017 Test Component Flag Result Reference Range DHEA-S µg/dL 107 35 - 430 TSH µIU/mL H 7.030 0.358 - 3.74 T4, Total µg/dL 7.2 4.5 - 12.5 T3, Free pg/mL 3.6 2.2 - 4.0 T4, Free ng/dL 0.87 0.76 - 1.46 Cortisol µg/dL 6.5 3.1 - 22.4 Anti-TPO Ab IU/mL H > 1000.0 0.0 - 35.0 Anti-Thyroglobulin Ab IU/mL H 97 ND - 40 Thyroglobulin ng/mL 38 <= 55 Thyroxine-binding globulin, TBGSAMPLE µg/mL 20 14 - 31 10401 Town Park Drive, Houston, Texas 77072 USA CLIA# 45D0710715 (800)227-LABS(5227) / (713)-621-3101 James W. -
Evolution of Hypothyroidism in Familialgoitre Due to Deiodinase
Postgraduate Medical Journal (1986) 62, 477-480 Postgrad Med J: first published as 10.1136/pgmj.62.728.477 on 1 June 1986. Downloaded from Evolution ofhypothyroidism in familial goitre due to deiodinase deficiency: report of a family and review ofthe literature Harry J. Hirsch, Shmuel Shilo and Irving M. Spitz Department ofEndocrinology andMetabolism, Shaare Zedek Hospital and Hadassah Hebrew University Medical School, Jerusalem, Israel and The Centerfor Biomedical Research, The Population Council, New York, N. Y., USA Summary: We studied two sisters who developed large non-toxic goitres in adolescence. Deiodinase deficiency was diagnosed by a rapid thyroid uptake ofradioactive iodine (RAI) at 2 hours associated with a marked fail in thyroidal 131I by 24 hours. Serial RAI scans in the second patient documented evolution of the iodine-deficient state. Conservation of intra-thyroidal iodine stores was maintained by avid iodine uptake and failure to release organified 1311. With progressive loss of inorganic iodine, hypothyroidism developed, associated with a rise in serum TSH which further exacerbated the loss of iodine. Treatment with L-thyroxine resulted in an improvement ofthyroid function, but normalization was achieved only after small doses of Lugol's iodine were administered. These studies illustrate the variable nature and late onset ofan inborn error ofthyroid metabolism. This family supports an autosomal recessive mode of inheritance for deiodinase deficiency. We have documented progression from a euthyroid to hypothyroid state resulting from decompensation of iodine conservation mechanisms. copyright. Introduction We have studied two sisters who developed large non- The mean ± s.d. basal TSH levels in 14 female controls toxic goitres in adolescence. -
Role of Thyroid Hormones in the Development of Gonadal Sex, External Morphology and Intestinal System of Zebrafish (Danio Rerio)
ROLE OF THYROID HORMONES IN THE DEVELOPMENT OF GONADAL SEX, EXTERNAL MORPHOLOGY AND INTESTINAL SYSTEM OF ZEBRAFISH (DANIO RERIO) by PRAKASH SHARMA, B.S., M.S. A Dissertation In BIOLOGY Submitted to the Graduate Faculty of Texas Tech University in Partial Fulfillment of the Requirements for the Degree of DOCTOR OF PHILOSOPHY Approved Dr. Reynaldo Patiño Chair of Committee Dr. Gregory D. Mayer Dr. James Carr Dr. Lauren Gollahon Dr. Nathan Collie Dr. Richard Strauss Dominick Joseph Casadonte Dean of the Graduate School December, 2012 Copyright 2012, Prakash Sharma Texas Tech University, Prakash Sharma, December 2012 ACKNOWLEDGMENTS First, I am privileged to thank Dr. Reynaldo Patiño, my major advisor and mentor for his guidance and encouragement which have been of immense support. He has been there to help and extend his guidance, anywhere, anytime, even at wee hours despite his busy schedule. Through him, I have not only picked up skills and a sense of responsibility, but also a whole new level of dedication. It is definitely a lifetime opportunity to have worked with an efficient and resourceful scientist like him. I am honored to thank my Committee Members for their enthusiasm to scrutinize my research. Thanks to Drs. Gregory D. Mayer, James Carr, Lauren Gollahon, Nathan Collie, and Richard Strauss. Their suggestions, ideas and information on the analysis of my study were of great significance. I could not have asked for a better cooperating team. Also, a million thanks to Dr. Gregory D. Mayer for supporting and guiding me immensely throughout my research program and for allowing me the opportunity to work in his lab.