Annual Report

Contents

PRESIDENT’S FOREWORD 004

SKOLTECH IN BRIEF 006

01 / FOCUS AND GOVERNANCE 012

Human Capital 014

Institutional Development 030

Strategic Communication 040

02 / ACADEMIC & TECHNOLOGY EXCELLENCE 048

Teaching & Learning 053

Research Excellence 061

Integrating Innovation 104

03 / VALUE GENERATION 112

Industry Funded Research 114

New Enterprises & Technology Licensing 118

Professional Training 122

Advisory Services 124

04 / CAMPUS 126

05 / OPERATIONAL MANAGEMENT 132

GLOSSARY 135 3 I am pleased to introduce the Annual are used in the aerospace industry, was Report 2018, the third year of my successfully developed and delivered to Presidency. ISS Reshetnev, allowing for the production The speed and scale of development of materials that were previously imported during 2015 – 2018 required commitment to . The Enhanced Oil Recovery and efforts from our faculty, researchers, Lab is secured with R&D contracts engineers, students, alumni, management by largest companies such as Lukoil, and Trustees – all of whom who made Gazpromneft, Zarubezhneft, Rosneft, Total, Skoltech what it is today. and Schlumberger for a year ahead. The We are a fully operational international specialists of the Center for Energy Science university, attracting for permanent jobs and Technology have set-up a production line specialists with multi-year experience at of cathode materials based on lithium-iron- the world leading universities and high- phosphate сompounds, outdoing the world’s tech companies. We have established best counterparts by 8-10 %. The materials multidisciplinary teams working in the areas will serve for advanced batteries of medium of global science & technology agenda – and large-scale capacities. The first prototypes artificial intelligence, life sciences and of lithium-ion batteries of small capacity health, agrotechnologies, photonics & (for smartphones) have been designed. quantum materials, cutting-edge Joint research in genome editing (CRISPR- engineering and advanced materials. technologies) with Rutgers, MIT and Harvard Our reputation for academic & technology led to cutting-edge results protected with excellence was advanced by a number of three joint patents. The agreement on the remarkable results. Let me give you some joint usage of inventions has already allowed examples. the commercialization of results. An equipment complex for the production Our publication output is on the level of of aluminum honeycomb packs, which international young universities, holding top

4

ANNUAL REPORT // SKOLTECH President’s foreword

positions in the world university rankings – as speakers on the top-international KAIST, Nanyang, HKUST – which is conferences; during the year more than a clear evidence of high qualification of 160 high-profile official delegations, our academic personnel and students. representing foreign ministries, diplomatic I am proud to say that this year we have missions, international universities and seen the highest amount of sponsored global high tech companies visited our research funding – a remarkable 1.1 billion state-of-the-art Campus, located in Skolkovo was raised via contracts with leading national Innovation Center with unique infrastructure and international companies and grant for life and work in the high-tech sector funding – Airbus, Bosch, Bitfury, Huawei, of the Russian economy. LG Electronics, Phillips, Total, Volkswagen, Very recently, Zhores Alferov, a man AM Munich Research Institute, Horizon of great mind and bright personality, 2020, RSF, RFBR and others. 2 billion rubles passed away. Fueled by earnest love for has been secured for the next three years. his motherland, he lived a long life full In 2018, Skoltech graduated its fourth of accomplishments, but above all, he class. About 50% are employed in Russian was an outstanding scholar fully devoted high-tech companies (Sberbank, Yandex, to science. He made world-changing Biocad and others), R&D divisions of discoveries, founded scientific schools international companies (Huawei, Cisco), and nurtured new talents. He was not only research institutions (Kurchatov, Russian a co-Chair of Skolkovo Scientific Advisory Quantum Center, institutes of the Russian Council, but a true believer of Skolkovo Academy of Sciences). 8% of graduates project. This is irreparable loss for all established their own startups, 38% are our community. pursuing PhDs, mostly at Skoltech. In the following pages you will read more We are visible in Russia and abroad. about our inspiring results, achieved by Skoltech scholars are regularly invited individuals and teams – Skoltech community.

Alexander Kuleshov Skoltech President 5 Skoltech In Brief Mission

Skoltech was founded in 2011 with Skoltech forms a part of the Skolkovo the vision of being a world-leading academic community which creates a new, self- institute of science and technology. sustaining innovation ecosystem providing As an academic institution, Skoltech an engine for Russian high-tech industry primary mission is academic & technology and attracting foreign investments. In this excellence in target domains. This includes paradigm, Skoltech acts as a catalyst performing cutting-edge basic and applied to foster cutting-edge research in research and educating next generation the advanced areas of crucial importance of science, technology and business leaders. for Russia, promote entrepreneurial activity Also, as a leading academic institution, and train internationally competitive Skoltech generates value in form of industry- specialists capable of working in the rapidly funded research and results implementation, changing research and technology landscape. new enterprises established by scholars, Further, Skoltech adopts advanced engineers, students and alumni, technology international practices in research, licensing, services of shared facilities, education, innovation & entrepreneurship, professional training, advisory services. and disseminates them to Russian Therefore, Skoltech reinforces Russia’s universities and academic institutions. technology excellence in target domains Therefore, in addition to direct monetary and bridges the gap between applied return, Skoltech creates significant indirect research and industry. long-term economic and social impact.

DMITRY MEDVEDEV, Prime Minister of the Russian Federation: “Most of all, I was impressed not even by state-of-the-art equipment or outstanding Campus architecture, but Skoltech spirit and atmosphere, it is unique.” 6

ANNUAL REPORT // SKOLTECH Snapshot & Trends

Focus Academic Excellence Target Domains 6 MSc and PhD 17 degree programs Centers for Research, 9 Education & Innovation papers in Scopus, 5.8 WoS per faculty Center for Entrepreneurship 1 & Innovation papers in Index journals per faculty 0.5 headcount

grants of Horizon 2020, 68 RSF, RFBR Human Capital growth in grant funding 65% compared to 2017 129 Faculty Postdocs & 229 researchers Value Generation Engineers & 134 technical staff 43 Enterprises Students from 1000 45 countries 26 are Sk residents Alumni 400 108 R&D contracts growth in R&D contracts funding 99% compared to 2017 Funding secured secured under Facilities R&D contracts of state- Rub and grants for 2 bln of-the-art 2019 – 2022 136,000 sq.m Campus

Human Capital: data is provided as of the end of 2018. Academic Excellence: data on publication output is extracted from Nature Index,WoS, Scopus as of March 1,2019. Also see page 28 (Annotation of Institutional KPIs)”. Value Generation: Enterprises established by Skoltech faculty, researchers, students, alumni (cumulative from 2013). Data on enterprises and R&D contracts as of the end of 2018. Funding secured: data as of March 1, 2019. 7 Trends in Figures

Academic & engineering personnel MSc and PhD intake, cohort

600 977

500

129 400 481 514 300 104 229 200 86 219 180 196 60 100 51 112 92 28 74 13 4 20 9 20 67 77 0 3 7 25 27 2012 2013 2014 2015 2016 2017 2018 2012 2013 2014 2015 2016 2017 2018

Engineers & Technicians Intake Cohort Posdocs & Researchers Faculty

Graduates (cumulative) Attracted funding (mln, Rub)

400 1112

224 569 132 389 265 51 61 80

2015 2016 2017 2018 2012 2013 2014 2015 2016 2017 2018

*2015 – Skoltech first graduation Attracted funding includes R&D contracts, grants, consulting services, professional training 8

ANNUAL REPORT // SKOLTECH Papers in Nature Index journals Scopus Field-weighted Citation Impact2 by faculty headcount1 (2018) 2015 – 2018

Caltech 2.7 MIT 2.38 Skoltech 1.51

United States 1.42 MIT 1.6 Germany 1.41 France 1.34 Skoltech World 1.00 Nanyang 0.5 KAIST HKUST 0.3 0.5 BRICS 0.90 0.3 Russian Federation 0.73

Establishment: MIT (1861), Caltech (1891), KAIST (1971), Nanyang (1991), HKUST (1991), Skoltech (2011)

New enterprises (cumulative)

26

19 12 4 17 1 9 6 7 1 1 2013 2014 2015 2016 2017 2018

Non-SK residents SK residents

Sources of financing (mln Rub)

2018

2017

2016

2015

2014

2013

0 1,000 2,000 3,000 4,000 5,000 6,000 7,000

SK Grant Contracts & grants Endowment income distributed Other sources

1 Data is provided as of March 1, 2019. Sources: Nature Index, university web pages. 2 Indicates how the number of citations received by papers compares the average number of citations received by all other similar papers index in Scopus (data as of March 1, 2019. SciVal source) 9 Skoltech Academic Network

Univ. of Calgary (CAN)2 (Joint Hydrocarbon Recovery Lab)

Polytechnique Montréal (CAN)

MIT2

Key: Stage of relationship

Co-Founder/partner 1

Active operational1 31

Formal Interest (MoU) 52

Contact established 77

Faculty collaborators 972 Univ. of Santiago (CHI)

1. E.g., contract, research, academic exchange 2. Stategic relationship as defined by having: extersive Academic exchange, joint R&D investment, global industrial partners, gateway 10 to other institutions

ANNUAL REPORT // SKOLTECH Newcastle Univ. (GBR) Univ. of Southhampton (GBR) Univ. Grenoble (FRA) DLR (GER) Univ. Ulm (GER) TU Munich (GER), (Joint Additive Mfg Lab with Oerlikon)2

Aalto Univ. (FIN) SPbAU (RUS) MIPT (RUS)

KFU (RUS)

TPU (RUS)

FEFU (RUS)

Nat’l Science & Tech Dev. Agency (NSTDA)

Curtin Univ. of Tech. (AUS)

The map designed by freepic.com The 11 12

ANNUAL REPORT // SKOLTECH Focus and Governance /01 Human Capital

14 Skoltech teams at the ceremony “Top Team Performance Award 2018”

ANNUAL REPORT // SKOLTECH ACADEMIC & ENGINEERING PERSONNEL

The strategic priority of 2018 was to hire and faculty network resulted in applications ambitious junior faculty from international from Germany, UK, France, Switzerland, markets, support academic career growth USA, Russia, South Korea, China and other of scholars showing outstanding performance countries. Based on expert review and and contribution to Skoltech development. decisions of the Appointment, Promotion Leveraging favorable environment and Tenure Committee of Skoltech Academic at Skoltech, recruitment efforts through Council, 27 top-candidates became Skoltech advertisement on the international portals faculty.

Geography of faculty hires

Saudi Arabia Japan 1 1

Russia Europe 6 10

USA 9

Europe: University of Leicester, Universität Hamburg, Helmholtz Institut Jena, Bournemouth University, Aberystwyth University, Fritz-Haber-Institut, Technische Universität Darmstadt, Royal Holloway University of London, University of Southampton, Università degli Studi di Roma “La Sapienza” USA: Massachusetts Institute of Technology, University of Michigan, University of North Carolina at Charlotte, University of New Jersey, Schlumberger-Doll Research Center, Schlumberger Reservoir Laboratory Russia: Institute of Bioorganic (RAS), Lebedev Institute (RAS), Institute of Physics of the Earth (RAS), Lukoil Engineering, Integra Group Japan: RIKEN Brain Science Institute Saudi Arabia: King Abdullah University of Science and Technology

1 www.timeshighereducation.com, www.academicpositions.com, www.nature.com, www.jobs.ac.uk. 15

/01 FOCUS AND GOVERNANCE Faculty promotions: • Vladimir Palyulin has impressive postdoc experience, starting as a researcher • Prof. Alexey Frolov promoted to Associate at Technische Universität München for Professor for impressive track record, 5 years, where he received a personal attracting industry funding, including two DFG grant, then one year as a research large contracts with Huawei, contributions associate and a teaching experience at to the field of Information Theory. the Cambridge University. • Dr. Alexander Bernstein promoted to Professor • Dmitry Yarotsky, Dr. of Science (Habilitation), of the Practice for intensive participation in has international experience as a postdoc a number of industrial projects, leading one in University College Dublin and as of them; strong publication activity (30 publi- a Humboldt Fellow in Germany, as well cations in last four years) and developing as industrial experience and a strong an original course on modern statistics. publication record. • Prof. Georgii Bazykin promoted to Associate • Maxim Panov played a key role Professor for excellent publication record in establishing educational portfolio including in Science, Genome Research, of CDISE as coordinator of two MSc Molecular Biology and Evolution journals, and one PhD program, plus a balanced initiation of a number of important research combination of industrial and academic projects, development of original, popular experience. course “Population and Medical Genetics”. • Mikhail Belyaev demonstrated excellence • Prof. Andrei Osiptsov, Dr. of Science in applications of mathematical and (Habilitation), promoted to Associate computer science methods in the area Professor for active development of of neurobiology, in particular, for collaboration with industry, resulting classification of structural connectomes. in establishing the joint laboratory • Maria Sokolova demonstrated teaching with Gazpromneft company. He also excellence by developing curriculum of demonstrated profound teaching activities. the Molecular Biology laboratory course • Prof. Dmitri Koroteev promoted to Associate and Summer school on antibiotics, her Professor for stated immense experience in research on novel RNA polymerases had high-tech segment of oil and gas industry, a clear basic science value and may good publication record, attraction of provide novel enzymes for biotechnology. extensive portfolio of industry-related projects. • Pavlo Gavrylenko stated a solid publication • Prof. Dzmitry Tsetserukou promoted to record in high impactful journals specialized Associate Professor for development of original in mathematical physics, a rapid growth research and educational program in Robotics of scientific productivity, impressive teaching and active work with students (Intelligent experience. Robotics lab has graduated more than 20 • Henni Ouerdane showed excellent students), leads the reSet team, which became publication record, addressing challenged champions of Eurobot Open Russia 2018. and elucidated fundamental problems on thermodynamics and coupled transport The first cohort of postdocs, stated theory of heat and electricity. outstanding performance and potential, • Federico Martin Ibanez demonstrated was promoted to Assistant Professorship: academic performance in power electronics comparable with international peers, in • Maria Pukalchik has a balanced combination addition he contributed to development of industrial and academic experience and of Skoltech Smart Grids Lab. work in the area of Digital Agriculture – a breakthrough technology which may As of the end of 2018, Skoltech had 129 finally transform agriculture into industry, professors. The share of junior and mid-career not surprisingly, she received 5 grants as faculty increased by 5% in comparison with 16 PI from RFBR and RSF. the previous year.

ANNUAL REPORT // SKOLTECH Faculty headcount by Centers Faculty headcount by rank

0 5 10 15 20 25 1% 3% 7%

CDISE 20% 21% CLS 25% CNBR 20% 21% CDMM 22% SC CHR 60% 55% CEST 47% CPQM CAS

CEI 2016 2017 2018

As of beginning of 2018 Senior

Hired Mid-career

Faculty promoted Junior

Researchers promoted Visiting

* For the purpose of calculation the faculty cohort indicated “as of beginning of 2018” does not include faculty promoted during the year.

Skoltech postdocs and researchers selection, installation and commissioning supported the CREIs in implementing of equipment, design and development development plans by conducting R&D and of premises and auxiliary sub-systems, scientific projects, preparing new proposals, maintenance of storage and materials establishing new enterprises. Engineers management, developing procedures and and technical staff contributed on a vast protocols on research equipment, ensuring majority of laboratory activities, e.g. health and safety requirements.

IVAN OSELEDETS, Associate Professor, recipient of 2018 Presidential Award in Science and Innovation: “Today everyone is talking about digital economy and artificial intelligence. We have a strong scholarly tradition in mathematics and physics, which I believe is underutilized. It would be great to have a “Year of Mathematics,” embracing both pure mathematics and computational mathematics, which we actively working on. This would help us in many ways.” 17

/01 FOCUS AND GOVERNANCE Postdocs, researchers, engineers, technical staff

2018 166 63 106 28

2017 128 56 62 15

2016 81 31 21 6

Postdocs Researchers Engineers Technical Staff

The year marked a range of international • Dr. Mikhail Bershtein received and national awards: Government Award for Young Scientists for a series of studies on theory of represen- • Prof. Ivan Oseledets received the President tations of infinite-dimensional algebras, of the Russian Federation Award in Science • Dr. Maria Logacheva received Moscow and Innovation for developing breakthrough Government Award for research computational technologies for solving multi- accomplishments in the functional and dimensional tasks in physics, chemistry, biolo- evolutionary genomics and metagenomics gy, data analysis based on tensor expansions, of the flowering plants, • Prof. Mikhail Finkelberg was invited as • Dr. Sergey Shmakov received Moscow a speaker at the International Mathematical Government Award for discovery of Congress 2018, new types of CRISPR-Cas systems and • Prof. Andrzej Cichocki was awarded by the their use in genome editing and other International Digital Signal Processing Society biotechnological applications. for his pioneering contributions in multiway • Dr. Stanislav Fedotov won the “Energy signal processing and their applications, of Youth” Award from the Global Energy • Prof. Victor Lempitsky was honored with the Association in the all-Russian contest of “Scopus Awards Russia” as the most cited youth research projects in the field of energy scholar in the subject area “Computer Science”, for development of potassium-ion batteries.

SERGEY SHMAKOV, PhD in Life Sciences and winner of the 2018 Moscow Government Award for Young Scientists: “Skoltech is a world-class university, which, as proved by our example, allows for making 18 notable discoveries and effectively disseminating them both to academia and industry.”

ANNUAL REPORT // SKOLTECH Faculty by Centers

President of the Russian Federation presenting the Award to Skoltech professor Ivan Oseledets

Winners of the 2018 Moscow Government Award for Young Scientists 19

/01 FOCUS AND GOVERNANCE STUDENTS & ALUMNI

In 2018, the cohort reached 1000 of regular München, University of Toronto, Danmarks and visiting students. International enrolments Tekniske Universitet, University of York, Higher (regular students) from 45 countries made 22% School of Economics, Moscow Institute of on PhD and 17% on MSc programs. In terms of Physics and Technology and other universities the gender balance, 30% of students are female. participated in Skoltech visiting program. Almost 50 students from Massachusetts In most cases, the students were engaged Institute of Technology, Technische Universität in research projects under faculty supervision.

International students by citizenship Geography of visiting students

Americas Asia Europe 10% 4% 21% Asia Europe Russia 14% 18% 59%

Africa & Middle North East America 26% CIS 19% 29%

Visiting students by university: Russia: Higher School of Economics, New Economic School, Moscow Institute of Physics and Technology, Russian Presidential Academy of National Economy and Public Administration North America: Massachusetts Institute of Technology, University of Toronto Europe: Technische Universität München, Universiteit Hasselt, Imperial College London, Danmarks Tekniske Universitet, Ruhr-Universität Bochum, ISAE-SUPAERO Institut Superieur d`Aeuronautique, Universidad de Alicante, University of York, Università di Pisa Asia: University of Electro-Communications, Sharif University of Technology

In support of maintaining Skoltech provisional agreements with Stanford, Brigham international study environment, a new Young University, State University of New initiative – Global Campus was launched. York, University North Carolina Asheville were It will offer students from the USA and Europe reached for hosting students in summer 2019. hands-on experience in fields of their interests The recruitment campaign to degree by internships at Skoltech labs, classes of programs targeted to attract talented, ambitious Russian, cultural program. The first participants students from Russia and abroad, maintaining 20 of the program were hosted by CDISE. The multi-cultural English-speaking environment.

ANNUAL REPORT // SKOLTECH Foreign Intake from 65 7 applications offline events in media projects from 126 universities in 25 1,6 mln + cities in Russia views 136 32 and abroad countries countries covering 8000+ prospective students

The campaign included outreach, of Economics. The format was successful: application, selection and enrollment activities 9 winners were enrolled to “Statistical Learning supported by Skoltech faculty and facilitated Theory” track of MSc Data Science program by the Student Department. Outreach (total track intake – 17 students). combined “target opportunities”, events held More than 15 000 candidates registered in Skoltech and select universities and cities, in Skoltech admission system, which is 40% and a “broad-brush” approach. higher compared to the previous year. About To ensure a broad coverage of prospective 70% of MSc and 80% of PhD applications students, targeted media projects were came from 135 countries. Selection of developed jointly with Russian portals such applicants included online test and review as postnauka.ru, vc.ru, meduza.ru, nplus1. of academic records followed by ru. The highlight of the year – «Это точно» the “Innovation Challenge” organized by (That’s true) comic book with 13 picture stories the Center of Entrepreneurship & Innovation. inspired by real research. In total, 848 applicants were invited to The recruitment channels were extended faculty panel interviews, 514 accepted with Olympiad held jointly with the Higher School offers and became Skoltech students.

Received applications 15,641

Invited to the pre-selection stage 3,596

Invited to the selection stage 848

Enrolled students 514 21

/01 FOCUS AND GOVERNANCE The intake 2018 is presented by 356 MSc With regards to academic background, 75% and 158 PhD students from 126 universities are graduates of the top-300 universities2 and in 32 countries. 20% of newcomers are inter- top-10 Russian universities, the rest are talents national students coming from 38 countries. from all over the world.

2017 2018 MSc PROGRAM INTAKE INTAKE

Data Science 77 116

Information Science and Technology 14 25

Life Sciences 48 44

Advanced Manufacturing Technology 10 24

Petroleum Engineering 17 27

Space and Engineering Systems 24 34

Energy Systems 12 19

Materials Science 19 25

Photonics and Quantum Materials 22 31

Mathematical and Theoretical Physics 12 11

Total 255 356

2017 2018 PhD PROGRAM INTAKE INTAKE

Computational and Data Science and Engineering 32 41

Life Sciences 16 20

Petroleum Engineering 7 26

Materials Science and Engineering 20 23

Engineering Systems 22 21

Physics 12 13

Mathematics and Mechanics 8 14

Total 117 158

ALEXANDER SAFONOV, Vice President for Development: “We widen opportunities for students and enrich experience at Skoltech by double degree and academic mobility programs. For example, for the second year in a row we organize Olympiad in collaboration with HSE, so that winners are enrolled at both universities, shape their study path from variety of courses, work on thesis under co-supervision. It enables faculty-to-faculty collaboration, and help shaping professional community.”

22 2 World University Rankings by Times Higher Education and Quacquarelli Symonds.

ANNUAL REPORT // SKOLTECH Intake academic background 0 30 60 90 120 150 180

Moscow Institute of Physics and Technology

Lomonosov

Higher School of Economics

Other universities in Russia

Other universities abroad

2016 2017 2018

As the first tool to measure recruitment quality and performance of MSc intake campaign efficiency, a survey among faculty positively. Compared to 2017, 32% teaching classes during Fall 20185 was of faculty rated the intake “much better” conducted. The majority of professors rated and “better”.

“How would you rate the level of MSc “How would you rate MSc intake intake enrolled in your course?” in comparison with intake of 2017?”

Poor Excellent Much Worse Much better 2% 16% 3% 3% Fair Worse 7% 11% Better 29% Good 33%

Very Good Same 42% 54%

Skoltech students are highly motivated Ulyanov, D., Vedaldi, A., & Lempitsky, V. (2018). to forge their unique pathways to success, Deep image prior. Proc. of CVPR (pp. 9446-9454). many of their hardworking endeavors turned • MSc team of Georgy Peshkov, Iskander into visible results. To name a few: Ibragimiov (supervisor Prof. Artem Myasnikov), Anna Gubanova, Dmitry Tikhomirov (super • Dmitry Ulyanov (supervisor Prof. Victor visor Prof. Dmitry Koroteev) won the 1st prize Lempitsky) received breakthrough results in Aramco Upstream Solutions Technathon in the area of deep learning and presented organized by the R&D Department of them in the IEEE Conference on Computer Saudi Aramco oil company. Valentina Vision and Pattern Recognition, already Ekimova (supervisor Prof. Evgeny cited 93 times. Chuvilin) became a winner in the national

5 67% response rate. 23

/01 FOCUS AND GOVERNANCE science competition in the area of Arctic Zhugayevych, A.; Stevenson, K. J.; Antipov, E. V.; research. Abakumov, A. M. “The Role of Semi-labile Oxygen .• Anna Maikova (supervisor Prof. Konstantin Atoms for Intercalation Chemistry of the Metal-ion Severinov) is the first-author of the paper Battery Polyanion Cathodes,” J. Amer. Chem. Soc. in the area of CRISPR in Nucleic Acids 2018, 140(11), 3994–4003 Research (Impact Factor 10.162). • Robotics reSET team led by Prof. Dzmitry Maikova, A.*, J. Peltier, P. Boudry, E. Hajnsdorf, Tsetserukou (Nikita Veliev, Evgeny N. Kint, M. Monot, I. Poquet, I. Martin-Verstraete, Safronov, Taras Melnik, Yakov Vasiliev, B. Dupuy and O. Soutourina (2018). “Discovery of Mikhail Kurenkov, Andrey Chemikhin, new type I toxin-antitoxin systems adjacent to CRIS- Sergey Vostrikov, Victor Livinyuk) PR arrays in Clostridium difficile.” Nucleic Acids became champions of Eurobot Open Res 46(9): 4733-4751. Russia 2018 competing with 22 teams • Tekhnologii kardiolog6 startup set by Natalia from top Russian universities and Glazkova’s (supervisor Prof. Tatyana companies and finished fifth at the Podladchikova) received a prestigious award Eurobot Final in France. at the Sevan Startup Summit in Armenia. • Roman Gonin (supervisor Prof. Mikhail • Ivan Tereshchenko (supervisor Prof. Artem Bershtein) became a winner of “Young Abakumov) is the first-author of the paper Russia Mathematics” prize for PhD students. in the area of metal-ion batteries in Journal • Ilya Fradkin (supervisor Prof. Nikolay of the American Chemical Society (Impact Gippius) and Alexey Lunkin (supervisor Factor 14.357) Prof. Mikhail Skvortsov) became “Unique Tereshchenko, I. V.; Aksyonov, D. A.; Drozhzhin, professionals” at Yandex Olympiad “I’m O. A.; Presniakov, I. A.; Sobolev, A. V.; a professional”.

Skoltech robotics team reSET won first place in the Russian round of the international Eurobot competition (April 2018)

4 Sense2Beat – a heart monitoring biosensor with clinical-grade accuracy. 5 Self-governance body representing students’ interests. The membership composed of students representing MSc and PhD programs, double degree programs, foreign students. 24 6 Sense2Beat – a heart monitoring biosensor with clinical-grade accuracy

ANNUAL REPORT // SKOLTECH Skoltech Student Council7 supported during three months after graduation in students on a wide variety of issues aiming Sberbank, Total, Yandex, Huawei Russia, at enriching experience. It organized freshmen Skoltech enterprises and other companies. orientation and community building events, 38% continued studies at Skoltech as well facilitated student clubs covering different as other top international universities, including interests, including sports, startups, culture, Carnegie Mellon, Princeton, Harvard Business languages. School, University of Calgary, Technische In 2018, 176 students became graduates. Universität München, Hong Kong University In terms of career paths, 59% were employed of Science and Technology.

Geography of Сlass 2018 Career paths of Class 2018

USA& Asia Other Other High tech Canada 2% 2% 3% industry 8% 28% Europe 8% Continue studies 38%

Startups 8% Russia Research 80% 23%

Abroad: Companies, startups, academia: Harvard Business School (#3*), ETH Zürich Sberbank, Total, Yandex, Huawei Technologies, (#7), Princeton University (#13), Toronto Megafon, Ozon.ru, Samsung, CISCO, University (#28), University of Manchester Rakuten, Tyler (startup), Lexy (startup), (#29), McGill University (#33), Hong Kong Blokhin Cancer Research Center, Kurchatov University of Science and Technology (#37), Institute, Novosibirsk State University, Carnegie Mellon University (#46), Technische Moscow Institute of Physics and Technology, Universität München (#62), Tohoku University Russian Academy of Sciences, Russian (#77), University of Calgary (#229) Quantum Center, + 20 more companies

7 Self-governance body representing students’ interests. The membership composed of students representing MSc and PhD programs, double degree programs, foreign students. * QS ranking 2019. 25

/01 FOCUS AND GOVERNANCE In 2018, Skoltech had a network of 400 to Skoltech Endowment Fund by founders alumni spread over 26 сountries. For the of Karfidov Lab. “We came to Skoltech in goal of supporting alumni community a set 2012 dreaming of establishing an engineering of events were held (e.g. business-breakfasts, company,” said Karfidov Lab co-founder meeting with 2nd year MSc students Dmitry Vasilyev. “Our dream came true, on sharing experience for career development). so we would like to thank our professors A milestone during the Campus inauguration, and supervisors and everyone else who was was a 1 mil Rub donation there for us for their support”.

Geography of Сlasses 2015 – 2017 Career paths of Сlasses 2015 – 2017

Asia Other Other 4% 3% 3% High tech USA industry 12% 34%

Continue Europe studies 12% 53%

Startups Russia 5% 69% Research 5%

Survey data (Feb, 2019 (response rate 86%).

Abroad: Companies, startups, academia: MIT (#1), Caltech (#4), EPFL (#22), Carnegie Samsung AI Center Moscow, Gazpromneft, Mellon University (#46), Aalborg university, Avito, Gazsurf, Huawei Russia, Megafon, Denmark (#343), KPMG, CISCO, Astro Digital Sberbank, Sbertech, Sputnix, Yandex, Inc and others Visionlabs, Karfidov Lab, TSNIIMASH + 20 more companies

EKATERINA MALYSHEVA, President of Student Council: “Skoltech is a growing university that offers a variety of activities to support a rapidly increasing student body. During this year, we have established eight new student clubs. Skoltech also expanded its presence in the broader student community by taking part 26 in inter-university team sports competitions. ”

ANNUAL REPORT // SKOLTECH // SUCCESS STORY DMITRY VASILYEV Skoltech graduate (2015), Karfidov Lab co-founder and Director for Development

I entered Skoltech in 2012, dreaming of design bureau we had had at MISiS could a technology entre-preneur career. In the two be transformed into a company. In 2014, years I spent here, I received an excellent I part-nered with Alexey (Alexey Karfidov, education and founded an engineering company. co-founder and general designer of Karfidov By the time I joined Skoltech, I had gone Lab – Ed.) to establish Karfidov Lab. through all the standard educational milestones With the knowledge and skillset I acquired and was ready for greater achievements, so at Skoltech, I created an engineering company I eagerly immersed myself in an atmosphere from scratch. At the time, I was only 23 and of enthusiasm, creation and accomplishment. still lacked experience, but I felt strongly Skoltech fully met my expectations I felt that encouraged by Skoltech professors and staff I belonged here and greatly enjoyed working who were always there to offer their guidance in this inspiring environment. and support. As of today, we have created 35 We had a stellar first class of graduates, high quality-jobs, and the company’s revenue where everyone not only excelled in science is approaching 100 million. My dream came but was highly motivated and geared for true, and I felt I ought to thank Skoltech for success. It is thanks to this stimulating this, so at the inauguration of Skoltech’s new environment that my skills gained at MISiS campus on September 1, 2018, Karfidov evolved into commercial undertakings. After Lab’s team made a donation to Skoltech’s I completed my studies at MIT and my first Endowment Fund to contribute to the year at Skoltech, I realized that the small development of quality education.

/01 FOCUS AND GOVERNANCE Skoltech. Gateway to the World // SUCCESS STORY MARIA SOKOLOVA Skoltech graduate (2018), Assistant Professor, Skoltech Center for Life Sciences

It was almost by accident that I found program, I wrote a scientific work, attended myself at Skoltech a few years ago, when major international conferences that helped I was still working at Konstantin Severinov’s to build strong ties with fellow scientists in lab at the St. Petersburg Polytechnic my field that are indispensable for academic University. I followed his advice and enrolled life, and visited multiple institutes and labs, in Skoltech’s PhD program, while having taking note of the best practices that I will a vague idea about the academic career and try to implement in my future lab. post-PhD opportunities. Soon after, I realized Last June, I defended my PhD thesis, that science is something I deeply enjoy and which was marked as “exemplary, stellar, cannot do without. and hard to match.” In August 2018, At Skoltech, I encountered a style of I organized a summer school dedicated learning totally different from what you’ll to the search and study of antibiotic- find in other Russian universities. I attended producing bacteria. Currently, I am preparing the Pedagogy Course by Magnus Gustafsson applications for several research grants and (professor at Chalmers University of working with my MSc students to ensure Technology, Sweden – Ed.) which was that they produce good dissertations. Last a valuable educational experience, both from but not least, I am blazing new trails while the teaching and learning points of view. following the research path I chose for my Thanks to Skoltech’s academic mobility PhD studies.

ANNUAL REPORT // SKOLTECH // SUCCESS STORY NIKITA RODICHENKO Skoltech graduate (2015), Tsuru Robotics founder and CTO

Coming back to Russia after completing the architecture of a complex system. Paired a one-year program at MIT, we (Anastasia with the ability to get things done, systems Uryasheva, founder and CEO of Tsuru Robotics, architecture became a major discipline in Tsuru and myself) realized that we wanted to work Robotics, which I oversee personally as the CTO. on a technology that had not yet developed I have never actually thought of creating a strongly in Russia. At that time, it was drones, business as an end goal, but rather as a way which later gave way to microelectronics and to bring my ideas to fruition and stick to my highly integrated systems. Currently, we are chosen path, working with a team of highly a full-stack robotics R&D company with skilled professionals. This became possible a focus on product development. not least because of Skoltech’s commitment My Skoltech Student MSc has had to encourage and support entrepreneurship. a strong influence on my career. I spent lots It allowed me forego fear and anxiety of early of time broadening my knowledge, making business development and focus on the things procurement decisions, taking care of that mattered. equipment, on maintenance, and trying Over the four years since its foundation, to help others with their tasks. In the our company has gained a firm foothold in meantime, I mastered rapid prototyping, the robotics development market. Last year, which later proved to be an invaluable skill a large portion of our projects were international, in real projects. Alessandro Golkar’s course with customers from Australia, Taiwan, Italy, and on Systems Architecture had a profound effect Ukraine. Since its foundation in 2015, Tsuru on my professional development, helping me Robotics’ turnover has tripled every year, and gain major hard skills, such as the ability the team keeps growing, too. We are continuing to develop, think through and evaluate to expand and address new ambitious goals.

/01 FOCUS AND GOVERNANCE Skoltech. Gateway to the World Institutional Development

KEY PERFORMANCE INDICATORS

The KPIs system measures the Institute’s years’ snapshot of the Institute’s development. output against goals of the Strategic Action In 2018, the Institute fulfilled the majority Plan, approved by the Board of Trustees of targets, exceeding some of them. A minor based on proposals of Senior Leadership and decrease in the number of graduates refers to CREI Directors. The table below indicates the fact that several defenses are postponed results of 2018 as well as provides a three to 2019.

2018 2018 KEY PERFORMANCE INDICATOR8 UNITS 2015 2016 2017 TARGET ACTUAL

Human Capital

Faculty Persons 60 86 104 120 129

Postdocs & Researchers Persons 74 112 184 215 229

MSc & PhD Students Persons 315 481 706 810 977

Academic Excellence

Publications in WoS, Scopus Units / faculty 2.5 4.4 5.6 4.6 5.8

Graduates Persons 51 81 92 180 176

Graduates involved in innovation activities % 51 67 67 65 69

Value Generation

Attracted funding mln. Rub 265 348 554.7 1064 1112

Patent applications Units / faculty NA NA 0.2 0.2 0.5

Skolkovo enterprises Units 9 12 19 25 26

Other

External funding % 15 15 20 25 25

30 8 Starting from 2019 the Institute has a revised KPI system.

ANNUAL REPORT // SKOLTECH Annotation

Faculty faculty having (i) long-term (one year or longer) employment agreements with at least 20% working time or (ii) candidates for faculty positions signed offersJ for employment under such terms. The indicator is calculated as of the end of calendar year

Postdocs & Researchers research personnel with employment agreements as of the end of calendar year

MSc & PhD Students total number of MSc and PhD students as of the end of calendar year

Publications indexed in WoS, Scopus ratio of faculty publications affiliated with Skoltech, indexed in Web of Science and/or Scopus, to the average number of faculty

Graduates total number of MSc and PhD graduates during the reporting year

Graduates involved in innovation activities ratio of MSc and PhD graduates (i) employed in industrial or research organizations in Russia, (ii) established new enterprises or employed in Skolkovo resident companies, (iii) doing intern- ships in the specified organizations & companies; or (iv) continue PhD studies in Skoltech (refer to MSc graduates) to the total number of MSc and PhD graduates during the reporting period; this indicator is calculated based on alumni survey

Attracted funding funding contracted within grants, R&D contracts, subsidies, service agreements (shared facilities, advisory services, professional training), technology licensing (royalty and IP sales)

Skolkovo enterprises (cumulative) enterprises (Skolkovo residents) established by Skoltech faculty, researchers, students or alumni

Patent applications total number of patent applications submitted by academic personnel to the average number of faculty

External funding, % income from external9 sources (grants, R&D contracts, pro-fessional training, services provided by Shared Facilities, income from licensing agreements, etc. to the total Institute’s expenses (excluding capital expenditures for Campus construction) during the reporting year

9 Excluding funding under the Skolkovo Foundation grant. 31

/01 FOCUS AND GOVERNANCE INSTITUTIONAL GOVERNANCE Skoltech governance system is presented of “Digital Petroleum” LLC11 and participation by Assembly of Founders, Board of Trustees, in share capital of “SmartCom”12 LLC. Academic Council and the President. Board of Trustees conducts general Assembly of Founders is the highest collegial oversight of the Institute’s activities. It approves governing body which approves the Charter, the Strategic Action Plan, Financial Plan, appoints Board of Trustees, Academic Council related reporting, also reviews proposals and the President, as well as makes decisions on major structural changes (e.g. launch on Skoltech membership in associations and or reorganization of CREIs). The Board legal entities. In 2018, the Founders approved supports the Founders with recommendations amendments to the Charter, Skoltech member- on Academic Council membership and ship in technology associations10, establishment President’s candidacy. In 2018, the Board

Arkady Dvorkovich Victor Vekselberg Alexander Alexander Tony F. Chan Chair of President of the Abramov Kuleshov President, King the Skolkovo Skolkovo Foundation, Chairman of the Skoltech Abdullah University Foundation, Chairman of the Board of Directors, President of Science and Chairman of the Board of Trustees Evraz Group Technology

BOARDOF TRUSTEES Board of Trustees Executive Committee

Richard Lester Edward Crawley Alexander Alexander Alexey Repik Associate Provost, Ford Professor of Povalko Galitsky Chairman of Massachusetts Engineering, MIT. CEO of Russian Co-Founder and the Board, Institute of Skoltech Founding Venture Capital Managing Partner, “R-Pharm” JSC Technology President Almaz Capital

Andrey Ivanov Chris Skirrow Natalia Kasperskaya Stanislav Smirnov Oleg Kharkhordin Deputy Finance Chairman of the Board President, Professor, University Rector, European Minister of of Trustees Audit InfoWatch, of Geneva University the Russian Committee, former Founder of Skoltech Founding in Saint- Federation partner at PwC Kaspersky Lab faculty Petersburg

Vladislav Valery Katkalo Paul Thompson Nikolay Pekka Surkov Rector, Director, Kudryavtsev Viljakainen Aide to the Sberbank ENIGMA Rector, Moscow Senior Advisor President of Corporate Consortium Institute of to the President the Russian University for Worldwide Physics and of the Skolkovo Federation Medicine Technology Foundation

10 National Supercomputer Technology platform, Association of market participants Internet of Things, BioTech2030, Medicine of the Future. 11 Spin-off of Skoltech Center for Hydrocarbon Recovery. 32 12 Enterprise (Skolkovo resident) established by Skoltech Center for Data-Intensive Science & Engineering.

ANNUAL REPORT // SKOLTECH Chair of the Skolkovo Foundation, Chairman of the Board of Trustees ​Arkady Dvorkovich and President of the Skolkovo Foundation, Chairman of the Board of Trustees Executive Committee ​Victor Vekselberg at the meeting of the Board of Trustees (December, 2018) 33

/01 FOCUS AND GOVERNANCE comprised 20 members – senior management adjustments to the annual budget. of the Skolkovo Foundation, leading Russian In its structure the Board of Trustees has and international universities, governmental the Executive Committee and the Audit bodies, institutes of development, founders Committee. In 2018, the Executive Committee of private high-tech companies. conducted preliminary review of the items required approval of the Board (interim reports In 2018, the Board approved Skoltech on KPIs, proposal on establishment the Annual Report 2017, structural changes in CNBR), while the Audit Committee reviewed “Life Sciences & Health” and “Energy Efficiency” issues related external audit process, control Target Domains, Strategic Action Plan environment and risk management. and Financial plan for 2019 – 2021. The Academic Council oversees Institute’s Board supported the President’s proposal educational, scientific, R&D and innovation on rotating the Academic Council member- activities. In 2018, the Council comprised ship13. Among other items reviewed – CEI 18 members – Skoltech faculty and senior development concept, fundraising strategy, management, external experts.

Chairman Prof. Clement Deputy Chairman Prof. Ildar Academic Prof. Grigoriy Prof. Alexander Fortin Prof. Rupert Gabitov Secretary Kabatiansky Kuleshov Interim Gerzer CPQM Dr. Alexander Advisor to Skoltech Provost, Dean Advisor to Safonov, Vice Skoltech President of Faculty Skoltech President for President ACADEMIC COUNCIL (ex-officio) President Development for Science

Prof. Iskander Prof. Nikolay Dr. Jean Prof. Artem Prof. Alexey Prof. Andrei Akhatov Kudryavtsev Botti Oganov Buchachenko Okounkov Director, Rector, Moscow CEO, CEST CEST CAS CDMM Institute of VoltAero Physics and SAS Technology

Prof. Edward Prof. Pavel Dr. Alexander Prof. Valery Prof. Boris Prof. Keith Crawley Pevzner Fertman Rubakov Fine Stevenson Ford Professor University Director on Moscow State CPQM CEST, Dean of Engineering, of California, Science and University, of Research MIT. Skoltech San Diego Education, Russian Founding Skolkovo Academy of President Foundation Sciences

During the year the Council reviewed (CDMM), Hybrid Photonics Laboratory the Strategic Action Plan, focusing on the (CPQM), Shared Facilities (Genomics, CREIs plans and the plans of new units – Advanced Imaging, FabLab and Machine Laboratory of Mass Spectrometry (CDISE), Shop, Micro- and Nanofabrication Laboratory of Cyber-Physical Systems Cleanroom, BioImaging and Spectroscopy).

34 13 Rotation of the Academic Council membership is planned due to expiry of the term of office (3 years).

ANNUAL REPORT // SKOLTECH On procedural side, the Council revised its which the Centers nominated faculty14. The Regulations to ensure a stronger role in oversee- Committees were fully operational, supporting ing R&D and innovation activities, determined the Institute with review and decisions on main principles for rotating membership based on activities.

COMMITTEE MEETINGS MAIN ACTIVITIES

Appointment, Promotion 9 regular • 98 reviewed cases of hiring, promotion and contract & Tenure Committee 1 absentee renewal • 56 positive resolutions taken

Education Committee 7 regular • approval of educational programs portfolio 5 absentee • approval of the academic calendar • approval of PhD Defense Policy • review the proposal on Professional Training Programs Policy • nomination of Final Attestation Committees Chairs • setting principals for partnership programs

Research & Innovation 5 regular • setting procedure to review research equipment requests Committee 6 absentee • screening and recommendations on purchase equipment requests • approval of scope of work and reports on MRAs

Skoltech Strategic Action Plan (SAP) defines 2019 – 2021 kept the goals set earlier, imply- the Institute’s priorities for development, key ing adjustment of the KPIs system to emerging tasks and activities, KPIs. The SAP is updated opportunities and challenges, CREIs develop- annually to adjust targets and scope of tasks ment planning, revision of tasks performed by considering interim results. The update for the Functional Blocks (page 35).

INSTITUTIONAL KPIs UNITS 2019 2020 2021

Academic Excellence

Publications indexed in WoS, Scopus No./faculty 4.1 4.2 4.3

Graduates Persons 240 360 360

Graduates involved in innovation activities % 70 70 70

Value Generation

Attracted funding mln. Rub 1250 1370 1500

Patents applications No./faculty 0.3 0.5 0.6

Skolkovo residents enterprises (cum.) Units 40 55 70

Other

External financing, % to the total of Institute’s % 25 26 27 expenses

14 The new composition of the Academic Council was pre-approved by the Board of Trustees (Dec, 2018) and will be submitted for approval of the Founders in Q1, 2019. 35

/01 FOCUS AND GOVERNANCE The CREIs planning took a few months and ing nominations of CREI Directors, Academic included self-assessment, review conducted Council, members of the Skolkovo Foundation by external Advisory Groups, elaboration and Trustees. In total, 37 experts, represent- of development plans to assure focus and ing international and Russian universities, alignment with the Institute’s vision of being a academic institutions, national labs, high-tech world leading academic institution. companies, innovation centers, supported the The Advisory Groups were formed consider- CREIs in a planning process.

Geography of experts

Russia Europe 27% 30%

USA, Canada 16%

Affiliations: Europe: Cambridge University, ETH Zurich, University of Duisburg-Essen, Institute of Science and Technology Austria. USA, Canada: MIT, University of Pennsylvania, Boston University, University of Colorado Boulder, Rutgers University, Calgary University, Stony Brook, Georgia State University, New Mexico State University, Roswell Park Comprehensive Cancer Center. Russia: Bosch R&D Center Higher School of Economics (Russia), National Research Center for Hematology, Novosibirsk State University, Institute of Solid State Physics, RAS, R&D Center EMC, DeGolyer and MacNaughton.

The Institute’s organizational structure is set in five functional blocks, to support the SAP execution. The chart (page 35) presents management structure, key functions and lines of responsibilities.

36

ANNUAL REPORT // SKOLTECH SHARED SHARED FACILITIES VP Tatyana Zakharova OPERATIONAL OPERATIONAL MANAGEMENT Finance & Operations Finance Legal Finance HR Admin Support IT Procurement CAS STUDIES ADVANCED ADVANCED Igor Krichever VP Gary CAMPUS Wentworth Campus Management Real Estate & Facilities Real CPQM PHOTONICS PHOTONICS & QUANTUM QUANTUM & Franko Kueppers Franko TECHNOLOGIES VP Stein Lawrence Affairs, IP int. Business Entrepre - neurship & Innovation CEST ENERGY ENERGY VALUE EFFICIENCY PRESIDENT Keith Stevenson Keith FOUNDERS GENERATION Alexander Kuleshov VP BOARD OF TRUSTEES OF BOARD Alexey Alexey Industrial Industrial Programs Science & Technology Development Analysis Ponomarev Cooperation Center for Entrepreneurship and Innovation SC Dean Research Keith Stevenson Research Facilities Grant Support CDMM

CHR Anton Ivanov ENGINEERING Iskander Akhatov CUTTING-EDGE Mikhail Spasennykh & ADVANCED MATERIALS ADVANCED & COUNCIL ACADEMIC Dean Education Anna Derevnina MSc & PhD Studies Library ACADEMIC EXCELLENCE Clement Fortin Interim Provost

Dean Faculty Clement Fortin Faculty & Posdocs Affairs Open Learning CLS CNBR & HEALTH & Fabio Macchiardi Fabio LIFE SCIENCES LIFE Konstantin Severinov Konstantin VP & Community Alexey Sitnikov Communications Strategic Strategic Communications STRATEGIC & STRATEGIC ORGANIZATIONAL ORGANIZATIONAL CDISE VP & ARTIFICIAL ARTIFICIAL & Safonov DATA SCIENCE SCIENCE DATA INTELLIGENCE Maxim Federov Alexander DEVELOPMENT, GOVERNANCE DEVELOPMENT, Development TARGET DOMAINS, SHARED FACILITIES SHARED DOMAINS, TARGET Institutional Development Student Affairs 37

/01 FOCUS AND GOVERNANCE In 2018, a few organizational changes into the manufacturing sector a set were made. of methodologies facilitating efficient utilization of developed and prospective • Establishment of the Center of Life design and engineering software and Sciences15 (Life Sciences & Health Target hardware systems. Domain) led by Prof. Konstantin Severinov. The Center will focus on Bioinformatics / • Establishment of Laboratory for Modeling Data-intensive Biology, Bioactive / Biode- of Multiphase Systems (CHR) in a part- rived Products, Agro, Biomed. nership with Gazpromneft. The Lab, led by Prof. Andrey Osiptsov, will develop • Establishment of the Center for Neurobiology advanced models of multiphase systems and Brain Restoration (Life Sciences & for design of new oilfield services tech- Health Target Domain) led by Prof. Fabio nologies. Macciardi. The Center will focus on human cognitive mechanisms and new tools and • Establishment of Hybrid Photonics techniques for restoration, maintenance, Laboratory (CPQM), led by Prof. Pavlos and optimization of brain functions. Lagoudakis, will develop experimental and theoretical tools to devise and test • Establishment of the Center for Energy an in-house analogue simulator utilizing Science and Technology16 (Energy Efficien- polariton graphs. cy Target Domain) led by Prof. Keith Ste- venson. The Center will conduct research • Establishment of Center of Excellence in areas of electrochemical energy storage “Wireless Communication Technologies and conversion, solar energy conversion and Internet of Things”17 (CDISE), led and storage, smart energy grids, energy by Prof. Dmitri Lakontsev. In consortium markets and regulation, computational with universities and high-tech com- energy materials. panies the Center will provide support and expertise to Russian companies for • Appointment of Prof. Franko Kueppers as development and application of technol- Director of the CPQM (Photonics and ogies, usage of products and services in Quantum Technologies Target Domain). the fields of Wireless Technologies and The Center will continue fundamental and Internet of Things. applied research in the area of photonics and quantum materials. • Establishment of Сenter of Competencies “Co-Brain Analytics” (CDISE), which • Establishment of Mass Spectrometry will held activities within the National Laboratory (CDISE) under guidance of Technology Initiative project on developing Prof. Evgeny Nikolaev. The Laboratory will a system for processing large neural data focus on biomedical mass spectrometry to support implementation of NeuroNet and omics technologies, analytical mass technologies. spectrometry and petroleomics, mass spectrometry for space research. • Opening the Center for Open Learning led by Tatyana Nikolenko. The Center will • Establishment of Laboratory of Cyber- coordinate development and implementation Physical Systems (CDMM) under of programs for gifted kids & wider commu- guidance of Prof. Ighor Uzhinsky. nity, including projects for “Skolkovo” gym- The Lab will develop and introduce nasium, “Sirius” Educational Center, park

15 Merge of the CDIBB & CTB. 16 Merge of CEE & CES. 38 17 National Technology Initiative project.

ANNUAL REPORT // SKOLTECH “Zaryadie”, “Kvantorium” Technopark. programs, provides support services, Following the SAP tasks, the Shared engages with alumni. Facilities were established – Genomics Core Facility, FabLab and Machine Shop, • Monitoring & Report Office facilitates Advanced Imaging Core Facility, Micro- Institutional planning and reporting, sub- and Nanofabrication Cleanroom, mits statistics required by the regulators. BioImaging and Spectroscopy Core Facility. • Analytical Department of Science & A few administration units were set to Technology Development organizes and con- support specific functions of the SAP: ducts analytical work and research in the field of science and technology policy for Russian • Student Department implements recruitment governmental agencies, institutes of develop- campaigns, leads activities for developing ment, high-tech companies. It also monitors student community and career advising global science and technology agenda.

39

/01 FOCUS AND GOVERNANCE Strategic Communications

The number of references to Skoltech Targeted media projects were launched exceeded 10 000 (6178 – in federal, 3193 based on original ideas adding traditional – in regional level media, 660 – in foreign scientific communication formats. Among the media). About 9 000 references were marked highlights is “Физически это возможно” in online media, among the rest – about 500 (Horizons of Physics) project in collaboration in news agencies reports and 600 in print with Kommersant. Two materials were selected media, TV, radio and blogs. for “Ogonek” magazine cover page of. The Compared to 2017, the number of breakthrough of the year is the comics book subscribers in VKontakte and Facebook “Это точно” (That’s true) awarded with Diploma increased by 5 000 and 2 000 respectively. of the Russian Prize “For Dedication to Science” Nevertheless, the ratio of audience involve- of the Russian Ministry for Science and Higher ment remained moderate, leaving room for Education. The “Mathematical Walks” were further improvement. Skoltech website traffic awarded with Diploma of Communication Lab amounted to 126 thousand people. of the Russian Venture Company in nomination The most striking Skoltech scientific results “Experiment”; in November 2018 a contract became topics of 38 popular science press with China’s publishing house “Rightol Media” releases prepared for a wide audience result- for publishing the book was signed (pilot circu- ed in increase of Skoltech media coverage. lation of 5,000 copies in Chinese).

Skoltech in media presence

6178 Federal

3193 Regional

660 Foreign

Visitors to Skoltech web page (2018) Delegations by country (2018)

Other Russia 28% 46% Russia 118

France 15 India 4% China 6 South Korea 3 USA 9% Other 27 Europe 13%

ALEXEI SITNIKOV, Vice President for Community Development and Communications: “The year marked a significant increase of Skoltech media coverage, number of faculty interviews on federal television and radio, popular newspapers and magazines, as well 40 as visits of Russian and international high-profile delegations.”

ANNUAL REPORT // SKOLTECH Skoltech hosted CDIO EUROPEAN REGIONAL Director of NMRC PM Oksana Drapkina and Skoltech MEETING 2018, focused on research- and President Alexander Kuleshov pictured at the innovation-based education. Edward Crowley, memorandum signing ceremony (March 2018) the Founding President of Skoltech, made an introductory statement. (January 2018)

European Research Council (ERC) President German billionaire Stefan von Holtzbrinck, co- Jean-Pierre Bourguignon on a visit to Skoltech. owner of Verlagsgruppe Holtzbrinck publishing From left: Stanislav Smirnov, Jean-Pierre company, pictured during his visit to Skoltech Bourguignon and Alexander Kuleshov (May 2018) (September 2018)

Lord John Desmond Waverly, member of the Heads of 50 diplomatic missions received at House of Lords of the UK Parliament, pays a visit Skoltech (December 2018) to Skoltech (October 2018) 41

/01 FOCUS AND GOVERNANCE MEDIA PROJECTS

«Цифророжденные» (Digital Natives) «Физически это возможно» 20,000 copies sold out (The Horizons of Physics) «Это точно!» Kommersant / Ogonek (That’s true) magazine Comic book with 2000 views; longreads / 13 stories featuring interviews with Prof. Vladimir Skoltech faculty research, Zakharov, Prof. Ildar Gabitov 5000 copies sold out and Prof. Valery Rubakov Eksmo Publishing house recognized as the best materials (Editor’s choice)

«Дежурный по планете» «Дежурный (Planet watch) Joint project по планете» with Sirius Educational Center, (Planet watch) «Математические and the Innovation Online media N+1 прогулки» Promotion Foundation Video on N+1 “Selfie (Mathematical walks) Online media OLOGY from the orbit” Publishing house Test “Are you ready to save 2600 views “Paulsen” (Russia) the seals in the White Sea?”, Rightol Media” (PRC) 2200 views Publication and book Longread “Seals on the Ice” 5000 copies for on Ology distribution in PRC over 2000 views

VALERIY RUBAKOV, Member of Skoltech Academic Council: “Amazing things happen in physics all the time. This was true 50 years ago and is even more true today. The topics we are studying now will not only help us to improve our 42 understanding of nature, but also bring about a great change for people.”

ANNUAL REPORT // SKOLTECH «Мастерская будущего» «Мастерская будущего» (Workshop of the Future) (Workshop of the Future) Online science magazine PostNauka Newspaper «Troitsky Variant – Nauka» Сourse covering 7 MSc Programs 6 Publications (71 materials: Lectures by Skoltech 570 000 views professors, videos, interviews, tests, textbooks, thesauri) 903 030 Views (web site, YouTube)

«Мастерская будущего» «Мастерская будущего» (Workshop of the Future) (Workshop of the Future) Online media N+1 Online media N+1 2 tests (RU / EN) 2 tests (RU / EN) on MSc program on MSc program “Energy Systems” “Information Science and Technology” Comic story Comic story

«Пять научных дисциплин, «Как устроено современное которые меняют бизнес» техническое образование и чем оно (Five Scientific Disciplines that are отличается от старого?» Changing Business) (How Modern Technical Education is Online resource for new generation Arranged and how it Differs from the Old) entrepreneurs vc.ru Online media MEDUZA Multimedia longread 10 cards 40 568 views 56 262 views

ILDAR GABITOV, Professor at Skoltech: “Society should be aware of what scientists are doing and scientists should make their research findings known to the broader public. Popular science papers in Russian and foreign editions are the most efficient and accessible science education format.” 43

/01 FOCUS AND GOVERNANCE SERVING WIDER COMMUNITY

Skoltech is strongly devoted to active en- • Turbo-science 2018 (supporting Skoltech gagement with wider community through a Center – Photonics and Quantum Materi- variety of events and programs designed at als, Prof. Boris Fine) – a distant 3-months educating gifted kids and students, science tutoring program aimed at inspiring Sirius popularization. graduates to choose a field of study con- nected with modern science and technol- Since 2017, Skoltech and the Talent and ogy. The program is implemented for the Success Foundation are cooperating to orga- second year. nize lectures and provide overall support to project activities of the Sirius Educational In addition to comprehensive education at Center18. In 2018, Skoltech activities includ- Skolkovo Gymnasium, Skoltech (Supporting ed over 15 lectures given by eight professors, Skoltech Center – Center for Open Learning, five multi-day educational programs, exper- T. Nikolenko) developed 12 science lab pro- tise provided on setting select laboratories. grams which allow students to improve their Among the key projects: practical skills and scientific thinking in the area of molecular biology and engineering. • Planet Watch (supporting Skoltech Center The programs will be introduced to wider – Space, Prof. Anton Ivanov) – a program school networks as advanced educational to attract students to space exploration. practices. The Center also provided Federal The first stage includes five competitions, Quantorium Technoparks Network with which will entail a series of educational scientific and technological expertise at the and learning activities that will enable International Contest of Children Engineering schoolchildren from all over the country Teams. Skoltech academic personnel refereed to gain first-hand experience with select eight tracks of final Quantorium Competition modern space technologies. The project held in Saint-Petersburg. is conducted in collaboration with Bortnik Foundation and RosCosmos. Skoltech welcomed 150 students, scientists and engineers for a three days Neuro • Participation in Big challenges 2018 Hackathon organized by the Centre of (Supporting Skoltech Center – Life Excellence for Wireless Communication Sciences, Prof. Konstantin Severinov; and the Internet of Things in collaboration Center for Entrepreneurship and with Research Centre of Neurology and Innovation, L. Stein.) – Involvement of Philips. The prize fund was awarded to the kids into projects with real life tasks and NeuroteamZero, Syberia, Squirrels per ha, objectives set by leading companies and Garbage Creators, FaRaDenZa and Siny research institutions. Three projects (brain Git. The members of all winning teams regeneration, search for universal markers got the opportunity to intern at the event’s of neural activity, CRISPR-CAS immunity) partner-companies, and take part in the in the “Personalized and prognostic medicine” Skoltech accelerator. Quantum Computing division were successfully carried out. Hackathon was held by Deep Quantum Lab, Two CEI professors delivered open lectures CDISE, jointly with Moscow State University. concerning project management. 14 teams of undergraduate and graduate

18 Established in 2015 in the southern Russian region of Sochi with a mission to identify and develop talented kids 44 & students with a particular emphasis in the natural sciences, arts, sports and technical creativity.

ANNUAL REPORT // SKOLTECH Skoltech students and young scientists taking part Skoltech students and young scientists taking part in the project session at Sirius (July 2018) in the project session at Sirius (July 2018)

Schoolkids honored for their personalized and First-graders of the Skolkovo Gymnasium visiting practical healthcare research projects performed the Skoltech Hydrocarbon Recovery Laboratory at the Sirius Educational Center with the support (April 2018) of Skoltech students (July 2018)

First-graders of the Skolkovo Gymnasium visiting First-graders of the Skolkovo Gymnasium visiting the Skoltech Hydrocarbon Recovery Laboratory the Skoltech Hydrocarbon Recovery Laboratory (April 2018) (April 2018) 45

/01 FOCUS AND GOVERNANCE students specializing in Physics, Computer different parts of Russia, Belarus, Science, Mathematics and Engineering Kazakhstan, Uzbekistan. Apart from participated in the event. lectures and seminars, the participants gained research experience in the Skoltech Lecture Hub was opened at the molecular biology teaching laboratory. brand-new Moscow Zaryadye Park. The first The school was a highly successful one three lectures were delivered by the President, according to students’ enthusiastic and Prof. Alexander Kuleshov, on the long-term excited responses. ‘It was the best Summer impacts of robotization and artificial intelli- School in my life. It was great, interesting gence, Prof. Philipp Khaitovich on evolution and fascinating! I have learned many and development of the human brain, and useful molecular biology skills and listened Prof. Konstantin Severinov on bacterial immu- to lectures by outstanding professors!’, nity and genomic editing. Over 250 people says one of the participants, Diana attended the lectures and thousands more Koldasbaeva from Kazakhstan. joined live broadcasting. Media and social networks coverage exceeded 30 and hundreds Under the guidance of Prof. Artem Oganov, of items, respectively. a group of Skoltech scientists prepared and delivered an intense Materials Science For the third year in a row Skoltech and course for gifted schoolchildren from across Independent Moscow of University organized Russia. The course included lectures on Young Mathematics in Russia Call for topics outside standard school curriculum – talented young scholars pursuing research Computational Design of Materials, Chemical in mathematics and its applications. An Communication Theory and Numerical international jury composed of leading scien- Methods and Scientific Programming. tists reviewed the applications and selected winners from St. Petersburg State University, The 3rd School of Young Scientists “Topical Skoltech, Higher School of Economics, Stek- Issues of Modern Electrochemistry and lov Mathematical Institute, St. Petersburg Electrochemical Materials Science” was held Academic University of the Russian Academy by the CEST. The school encountered >70 of Sciences. students from Russia, Kazakhstan and Belgium. The lecturing team comprised prominent The Undergraduate Summer School in zscientists from Japan, France, Belgium, USA, molecular biology was held by the CLS. UK, Switzerland, Luxembourg and Russia. The curriculum was developed by recent PhD graduate, Maria Sokolova, and A series of courses was delivered by CDISE is a unique combination of theoretical faculty and researchers during “Ostrov 10-21” expertise balanced with practice. event in the framework of University 2035 The school united 13 students from initiative in Vladivostok in summer 2018.

PAVEL TREHLEB, Director of Zaryadye Park: “We are happy to help children in gaining knowledge, discovering new gifts, and devel- oping creative abilities as well as a passion for science. Together with Skoltech, we will create new educational outreach programs to make the science learning process more 46 fascinating and easy-to-follow, even for elementary school kids.”

ANNUAL REPORT // SKOLTECH Skoltech President Alexander Kuleshov delivering Following Kuleshov’s lecture, Professor Dmitry an open lecture «Impacts of robotization and Teteryukov of the Skoltech Space Robotics Lab artificial intelligence on our future” in Zaryadye tells the audience about the lab’s latest research Park (November 2018) (November 2018)

The dataset for Neurohackaton’s scientific track Russia’s first Neurohackaton dedicated to was put together using CoBrain-Analytics data multi-ple sclerosis took place at Skoltech (November 2018) (November 2018)

Professor Konstantin Severinov giving an open Professor Philipp Khaitovich giving an open lec- lecture “From bacterial immunity to genomic ture “Human brain evolution” in Zaryadye Park editing” in Zaryadye Park (December 2018) (December 2018) 47

/01 FOCUS AND GOVERNANCE 48

ANNUAL REPORT // SKOLTECH Academic & Technology Excellence /02 CLEMENT FORTIN, Professor, Interim Provost, Dean of Faculty: “Academic and technology excellence are Skoltech raison d’être and great progress has been achieved since its foundation.” 50

ANNUAL REPORT // SKOLTECH The Institute’s framework for driving Russia and the world, Centers for Research, academic & technology excellence is built on Education and Innovation (CREIs), labs set the Target Domains and focus areas which in collaboration with industrial partners, address critical scientific, technological, and Center for Entrepreneurship and and innovation challenges and gaps facing Innovation (CEI).

DATA SCIENCE LIFE SCIENCES CUTTING-EDGE ENERGY PHOTONICS ADVANCED & ARTIFICIAL & HEALTH ENGINEERING EFFICIENCY & QUANTUM STUDIES INTELLIGENCE & ADVANCED TECHNOLOGIES MATERIALS

Center for Center for Life Center for Center for Center for Center for Data Intensive Science Design, Energy Science Photonics Advanced Science and Manufacturing & Technology & Quantum Studies Engineering Center for & Materials Materials Neurobiology & Brain Space Center Restoration Center for Hydrocarbon Recovery

Center for Entrepreneurship and Innovation

Centers for Research, Education development, and innovation potential and Innovation are main integrators of the Institute. In pursuing academic and drivers for implementing long- and technology excellence, the Centers term programs for developing human, conduct cutting-edge basic and applied education, science, research and research in the areas of specialization.

CDISE Artificial Intelligence, especially machine learning, data science, deep learning, quantum enhanced computation & Internet of Things.

CLS Bioinformatics / data-intensive biology, bioactive / bioderived products, agro science, and biomed.

CNBR Developmental neurobiology, molecular neurobiology, computational neurobiology, and brain restorations.

CDMM Materials, technologies, processes, digital engineering and management: polymer-based composite materials, 3D-printing technologies, thermal spray processes, digital design and manufacturing, and product lifecycle management.

CHR Geomechanics, enhanced oil recovery, geophysics and petrophysics of unconventional reservoirs, gas hydrates and permafrost, advanced reservoir simulations and data science in application to the oil and gas industry. 51

/02 ACADEMIC & TECHNOLOGY EXCELLENCE SC New approaches for system concepts, implementation and operating of complex systems through their lifecycle. Strategic thinking (technology design and management), advanced engineering (space hardware and robotic systems), complex systems applications (commercial applications and scientific exploration).

CEST Electrochemical energy storage, electrochemical energy conversion, solar energy conversion and storage, smart energy grids: systems and devices, energy markets and regulation and a cross-cutting thrust on computational materials.

CPQM Quantum materials (2D materials, superconductors, semiconductors, quantum-coherent systems). Photonics include basics of light-matter interaction, nano-plasmonics, metamaterials, polariton Bose-Einstein condensates, physics of optical communications, and biophotonics.

CAS Areas of geometric representation theory, string theory, conformal and gauge field theory, integrable models, combinatorics and singularity theory, symplectic geometry, topology, statistical physics, dynamical systems, and hyperbolic geometry.

The Centers lead development of educa- Huawei Innovation Lab was signed; the Lab tional domain, e.g. conduct globally competi- will focus on artificial intelligence including tive programs, participate in student outreach machine learning, neuron networks, computer and selection, supervise research projects vision, language processing, recommendation and thesis. With regards to value generation, systems. The agreements on setting labs with the CREIs contribute by establishing project Samsung, TopCon Global Positioning and teams and new enterprises, creating intel- Russian Post are in the pipeline. lectual property, conducting industry-funded Center for Entrepreneurship and Innovation R&D projects, advisory services. (CEI) is the Institute’s core element in fostering In support of the strategic initiative to and linking Centers’ research and education set industry-oriented labs, during the year with innovation and entrepreneurship. The CEI Skoltech opened Joint Laboratory on Additive nurtures a unique Skoltech culture of innova- Manufacturing (CDMM) with Oerlikon (Swit- tion and entrepreneurship by developing spe- zerland) and Technical University of Munich, cialized courses, involving Skoltech personnel, Joint Laboratory for Modeling of Multiphase students and alumni in establishing and devel- Systems (CHR) with Gazpromneft JSC. oping new enterprises. The CEI manages the The agreement on establishing Skoltech & Institute’s IP and leads technology licensing.

ISKANDER AKHATOV, Professor, Director of Skoltech Center for Design, Manufacturing and Materials: “Successful collaboration projects, such as the Skoltech and Oerlikon joint Additive Manufacturing Lab, and commitment to attain the challenging research goals helps push the boundaries of international cooperation. Oerlikon and Skoltech will expand their strategic 52 partnership to cover both the additive manufacturing and protective coating technologies.”

ANNUAL REPORT // SKOLTECH Teaching & Learning

Skoltech delivers and continues the year of graduation – 151 students suc- development of 10 MSc and 7 doctoral cessfully completed MSc studies and 25 programs. Almost 1000 full-time students PhD graduates received state diplomas. study at Skoltech: 594 MSc and 383 Total number of graduates – 391: 358 PhD. In 2018, Skoltech had its fourth MSc and 33 PhD.

MSc MSc MSc MSc MSc PROGRAM STUDENTS STUDENTS GRADUATES GRADUATES (2017) (2018) (2017) (2018)

Life Sciences 83 93 11 29

Data Science 130 177 25 50

Information Science and Technology 27 44 8 9

Space and Engineering Systems 53 67 12 18

Advanced Manufacturing Technologies 19 30 - 8

Materials Science 22 44 7 3

Petroleum Engineering 24 43 4 7

Energy Systems 19 27 10 6

Photonics and Quantum materials 29 48 7 11

Mathematical and Theoretical Physics 21 21 - 10

Total 427 594 84 151

PhD PhD PhD PhD PhD PROGRAM STUDENTS STUDENTS GRADUATES GRADUATES (2017) (2018) (2017) (2018)

Life Sciences 47 51 5 14

Computational and Data Science and Engineering 61 89 2 4

Engineering Systems 67 76 1 2

Materials Science and Engineering 34 51 - 3

Petroleum Engineering 27 51 - 1

Physics 27 36 - -

Mathematics and Mechanics 14 29 - 1

Total 277 383 8 25

Skoltech has developed and approved a to the Russian higher education sphere. In PhD Thesis Defense Policy in accordance with 2018, 17 Skoltech PhD students from 6 PhD high international standards, which is unique programs successfully defended their theses. 53

/02 ACADEMIC & TECHNOLOGY EXCELLENCE Life Sciences 5 8 Computational and Data Science and Engineering 1 4 Engineering Systems 1

Materials Science and Engineering 3

Petroleum Engineering 1

Mathematics and Mechanics 1

PhD thesis defenses (2017) PhD thesis defenses (2018)

All PhD thesis defenses was carried out successfully:

Life Sciences doctoral Program

Maria Sokolova Thesis title: Functional and Structural Analysis of a Non-canonical Multisubunit RNA Polymerase Encoded by Giant Bacteriophage AR9. Supervisor Prof. Severinov, Skoltech

Alexander Tyshkovskiy Thesis title: Molecular Signatures and Mechanisms behind Lifespan Extension. Supervisor Prof. Khaitovich, Skoltech. Co-supervisor: Prof. Gladyshev, Harvard Medical School

Aleksei Mikhalchenko Thesis title: Comparative Biology of Aging Through the Lens of Induced Pluripotent Stem Cells. Supervisor Prof. Khaitovich, Skoltech. Co-supervisor: Prof. Gladyshev, Harvard Medical School

Alexander Martynov Thesis title: Using Mathematical Modeling to Understand Prokaryotic Adaptive Immunity. Supervisor Prof. Severinov, Skoltech. Co-supervisor: Prof. Ispolatov, University of Santiago Chile

Ilia Kurochkin Thesis title: Comparative Analysis of Human Brain based on Mass Spectrometry Data. Supervisor Prof. Khaitovich, Skoltech.

Andrey Krivoy Thesis title: Primed CRISPR-Cas Adaptation in Type I-E System of Escherichia Coli: Use of Single-Molecule and Biochemical Assays to Verify Models of the Phenomenon at Molecular Level. Supervisor Prof. Severinov, Skoltech

Anna Moroz Thesis title: Preclinical Testing of New Modalities for PET Visualization and Treatment of RAS-Driven Cancers. Supervisor Prof. Severinov, Skoltech. 54 Co-supervisor: Prof. Evans, University of California.

ANNUAL REPORT // SKOLTECH Computational and Data Science and Engineering doctoral program:

Alexander Fonarev Thesis title: Matrix Factorization Methods for Training Embeddings in Selected Machine Learning Problems. Supervisor Prof. Oseledets, Skoltech.

Evgeny Frolov Thesis title: Low-Rank Models for Recommender Systems with Limited Preference Information. Supervisor Prof. Oseledets, Skoltech

Vadim Lebedev Thesis title: Algorithms for Speeding up Convolutional Neural Networks. Supervisor Prof. Lempitsky, Skoltech

Petroleum Engineering doctoral program:

Tatiana Bondarenko Thesis title: Evaluation of High-Pressure Air Injection Potential for In-Situ Synthetic Oil Generation from Oil Shale: Bazhenov Formation. Supervisor Prof. Cheremisin, Skoltech

Materials Science and Engineering doctoral program:

Evgeniya Gilshteyn Thesis title: Components for Stretchable Electronics based on Single-Walled Carbon Nanotubes. Supervisor Prof. Nasibulin, Skoltech

Aliya Glagoleva Thesis title: Development of kW Scale Hydrogen Energy Storage System. Supervisor Prof. Stevenson, Skoltech. Co-supervisor: Dr. Borzenko, Joint Institute for High Temperatures of RAS

ILIAS GIANNAKOPOULOS, PhD student in Computational and Data Science and Engineering: “I decided to study under the Skoltech PhD program, because I was impressed by professors’ approach for novel and innovative ideas that support solid research. Moreover, Skoltech environment and facilities are favorable to international students. Last but not least, I enjoy working on challenging projects, and Skoltech provides this opportunity.” 55

/02 ACADEMIC & TECHNOLOGY EXCELLENCE Four graduates defended thesis outside Skoltech in compliance with requirements of host institu- tion or Russian State standards:

Andrey Chekannikov Thesis title: Electrode Materials for Sodium-ion Batteries Based on Polyanion-type Compounds. Supervisor Head of laboratory, T. Kulova, A.N. Frumkin Institute of Physical Chemistry and Electrochemistry RAS. Place of defense – A.N. Frumkin Institute of Physical Chemistry and Electrochemistry RAS

Andrey Kuzmin Thesis title: Fast Methods for Dense Omage Correspondence. Supervisor Prof. Lempitsky, Skoltech. Place of defense – Federal Research Center “Computer Science and Control” of the RAS.

Pavlo Gavrylenko Thesis title: Isomonodromic Deformations and Conformal Field Theory with W-symmetry. Supervisor Prof. Opdam, University of Amsterdam, Prof. Marshakov, Skoltech. Place of defense – University of Amsterdam

Yulia Naraykina Thesis title: Coding Non-coding Human Telomerase RNA. Supervisor Prof. Dontsova, Skoltech, Prof. Rubtsova, MSU. Place of defense – MSU.

Each PhD Defense Jury consists of scientists with specific expertise relevant to the topic of the thesis. At least two of them are international experts from recognized universities and companies.

The list of institutions is presented below:

Russia Skoltech, Lomonosov Moscow State University, Institute of Molecular Genetics RAS, Dmitry Rogachev National Research Center for Pediatric Hematology, Oncology and Immunology, Higher School of Economics, A.V. Topichev Institute of Petrochemical Synthesis of the RAS, Kemerovo State University, Joint Institute for High Temperatures

Europe University College London, Max Planck Institute for Biology of Ageing, Max Planck Institute of Psychiatry, University of Zagreb, University of Bonn, Free University of Bozen-Bolzano, Technical University Darmstadt, University of Oulu, Lithuanian Energy Institute, University of Exeter, prudSys AG, Gravity R&D

Asia National University of Singapore, Tel Aviv University, RIKEN Center for Life Science Technologies

USA and Canada University of Illinois Urbana–Champaign, University of Georgia, Memorial Sloan Kettering Cancer Center, New York University, University of Houston, University of Calgary, University of the Western Cape, University of Rochester, Buck Institute for Research on Aging, NVIDIA 56

ANNUAL REPORT // SKOLTECH The international accreditation of graduate As it is mentioned in the evaluation report programs by French High Council for Evaluation of the Hcéres Experts Committee, “the of Research and Higher Education (Hcéres) establishment of Skoltech Life Sciences in compliance with Standards and Guidelines PhD program has been executed at highest for Quality Assurance in the European Higher international standards.” This high praise Education Area was launched in 2018. The Life is particularly important for Skoltech as a Sciences program was selected for accreditation young international university and allows it as one of the first PhD programs with the larg- to serve as an example to follow for other est number of graduates and thesis defenses. Russian institutions.

The key results in programs development for • two new courses were offered to develop 2018/2019 academic year are: skills of 1st year MSc students: English Toolkit and Mathematics for Engineers, • the range of courses was expanded to 207 • Entrepreneurship and Innovation (E&I) curriculum elements, stream was expanded to 10 courses, • introductory courses were woven into the number of courses focused on soft curricula to assist students with different skills development increased to 13, backgrounds to overview research areas, • the new course Pedagogy of Higher choose educational track and organize Education for PhD students was devel- rotation via laboratories: Introduction oped by Prof. M. Gustafsson (Chalmers to “Life Sciences” program; Introduction University, Sweden). The course is an to Petroleum Engineering; Introduction essential element of doctoral study to AMT; Introduction to Data Science; focuses on practical pedagogical skills Introduction to IoT; Introduction to useful for academic career. So far, 44 The Quantum Field Theory; Survey PhD students have successfully passed of Materials, the course.

2018 184 10 13

2017 155 8 7

2016 99 6 2

Courses in curriculum (total) Entrepreneurship and Innovation courses (E&I) Soft skills courses

The quality of courses and teaching is Department collected student feedback on measured by student satisfaction at the 180 courses. The average response rate has end of each course. The anonymous online gradually increased from 40% in 2017 to survey includes 10 questions with quali- 75% during 2018. Almost all courses were tative assessment of the course for further highly evaluated: >95% positive student improvement. During 2018, the Education feedback. 57

/02 ACADEMIC & TECHNOLOGY EXCELLENCE Fulfillment of the accreditation criteria

THE POSITIONING OF “The Life Sciences PhD Program is perfectly integrated into the THE DOCTORATE general strategy of Skoltech as a part of the Institute in creating excellence in research and teaching”

ORGANIZATION AND “The organization of the PhD program is flawless. It is organized MANAGEMENT OF based on meritocratic values that are in full agreement with the THE DOCTORATE institution’s and PhD program’s aim to become one of the leading research and teaching institutions in Russia and the world”

SUPERVISION “The supervision and training of students is conducted at AND TRAINING FOR highest international levels” DOCTORAL STUDENTS

INTEGRATION “Specific problems with respect to the job market have been OF DOCTORS INTO identified and the Skoltech team works on their part to facilitate THE JOB MARKET the integration of the doctors into the job market”

FINAL ASSESSMENT “Considering the accreditation criteria analysis detailed above, the accreditation committee issues the following decision: “FIVE-YEAR UNRESERVED ACCREDITATION DECISION”

58

ANNUAL REPORT // SKOLTECH Independent Study Period (ISP) is a unique each student has an opportunity to partici- practice in the Russian higher education land- pate in academic mobility from short pro- scape. The Skoltech community and invited grams, such as international conferences or instructors are encouraged to create and de- summer schools, to long-term visits to part- liver new courses to make the learning process ner host universities to conduct research. interdisciplinary and to enhance professional Academic mobility aims to immerse students and personal skills of Skoltech students. More into a global international ecosystem of sci- than 300 Skoltech students participated in 31 ence, research and innovations during study selected ISP courses: Pilot School, Science in at Skoltech. A high participation of 417 stu- Contemporary Art, Lean on Linux, Mysterious dents were supported for academic mobility, Russian Soul, Quantum Hackers Course, The including 144 long-term trips for research. Art of Public Relations, From Idea to Start-up, More than 80 universities and research cen- Introduction to Artificial Humor, and others. ters hosted Skoltech students: MIT, California Institute of Technology, Technical University Academic mobility is a special facet of of Munich, Max Plank Institute, Pasteur Insti- Skoltech education in the Russian context: tute, Airbus, Facebook, etc.

The graduates of PhD Life Sciences program

ANNA DEREVNINA, Associate Provost and Dean of Education: “In 2018, Skoltech began attaining international recognition of its education programs in compliance with Quality Assurance in the European Higher Education Area. The first Skoltech Life Science PhD program was successfully accredited by the High Council for Education of Research and Higher Education (HCERES, Paris, France). As mentioned in the evaluation report, “the establishment of the Skoltech Life Science PhD program has been executed at the highest international standards.” This high praise is particularly important for Skoltech as a young international university and allows it to serve as an example to follow for other Russian institutions.” 59

/02 ACADEMIC & TECHNOLOGY EXCELLENCE The role of e-library and virtual resources, called ProQuest Dissertations, which allows digital tools, and eLearning to encourage access to one of the world’s largest global Digital Learning Commons, significantly archives of dissertations and theses. Addition- expanded in 2018. At the moment, students ally, the research performance analytical tool have access to 16 universal and topic-specific SciVal was subscribed at the end of 2018. scientific databases, including Science Direct, The basic needs for a broader range of scien- Springer and IEEE, 4 bibliographic databases tific literature are covered by Springer e-books (Scopus, Web of Science, etc.) and patent da- collection, which is provided by Russian tabase Cipher. A new product was introduced Foundation for Basic Research (RFBR) grant.

2016 2017 2018

Print books collection, numbers 400 700 930

E-books, numbers 0 220 370

Springer e-books provided by Russian Foundation for Basic 32 000 70 000 85 000 Research (RFBR) grant, numbers

Full-text documents downloads from library data-bases, numbers 8 400 50 000 110 000

The number of full text scientific databases, The online course catalog (https://www. available for the students is growing con- skoltech.ru/en/education/course-catalog/) contains stantly. It is reflected in full-text documents the full syllabi of more than 200 courses and is downloads grow. E-books versions of most of now publicly accessible for all internal and exter- required books are available directly via course nal customers; the number of visits to the web- syllabi pages hosted on the Canvas LMS. page is almost 3 times more than a year before.

2016 2017 2018

Page views, number 41 000 70 000 186 000

Page views, % of total 11 11 28

Average page views/day, number 112 190 510

Canvas LMS is an instrument of teaching 60%, while in the Fall terms – about 90% of management and a useful tool of self-study courses used Canvas as an essential part of for students. During Spring terms of 2018, the their active learning approach. number of courses using Canvas was about

60

ANNUAL REPORT // SKOLTECH Research Excellence

Centers for Research, Education and Inno- Wos, Scopus)19, 60% are co-authored with vation contributed to strengthening Institute’s international partners. For the second year exposure in terms of publication input. in row Skoltech keeps the 3rd place among The six years’ record is presented with Russian academic institutions in Nature In- about 2 000 papers cited more than 16 dex (Subject “Life Sciences”) after the Rus- 000 times, the output of 2018 includes sian Academy of Sciences and Lomonosov 711 Skoltech affiliated papers (indexed in Moscow State University.

Papers in Nature Index journals Scopus Field-weighted Citation Impact by faculty headcount (2018) (2015 – 2018)

Caltech 2.7 MIT 2.38

Caltech 2.22

MIT HKUST 2.0 1.6 Nanyang 1.86

Skoltech Skoltech 1.51 Nanyang 0.5 KAIST HKUST 0.3 0.5 KAIST 1.25 0.3

Year of establishment: MIT (1861), Caltech (1891), KAIST (1971), Nanyang (1991), HKUST (1991), Skoltech (2011)

Scopus Field-weighted Citation Impact (2015 – 2018)

0 100 200 300 400 500 600

United States Germany United Kingdom China France Belgium Italy Finland Japan Netherlands Spain

19 Scopus data as of March 1, 2019. 61

/02 ACADEMIC & TECHNOLOGY EXCELLENCE The year of 2018 witnessed a significant • project of Prof. Evgeny Burnaev “Making growth of the Institute’s research income Machine Learning on Static and Dynamic raised on national and international grants. 3D Data Practical” will establish a mutually The grant funding in 2018 reached 234 mln beneficial collaboration between Tech- Rub, 65% higher compared to the previous nische Universität München and Skoltech. year. The total funding awarded on new pro- TUM will gain access to expertise and posals during 2018 is 370 mln Rub. Adding innovative machine learning and deep new grants awarded by March 1, 2019 the learning algorithms, while Skoltech will Institute secured 650 mln Rub for the period benefit from significant expertise of TUM of 2019 – 2022. in visual computing (sponsored by Russian Science Foundation), • for the 4th time Skoltech received direct EU funding in the framework of Horizon 2020. • project of Prof. Timofey Zatsepin will Project name: “Integrating High Resolution target to form the basis for the new Solar Physic” (2019-2022), approach in the cutting-edge technology PI: Prof. Tatyana Podladchikova, of RNA therapy, which can be used also for orphan diseases and in personalized • Russian Science Foundation grants within medicine (sponsored by Russian Science the President’s program for supporting Foundation), world-class laboratories were awarded to Prof. Artem Oganov (Laboratory • “My first grants” (Russian Foundation for of Computer l Design of New Materials) Basic Research) were received by Trofimov and Prof. Vladimir Zakharov (Laboratory Anton, Aksenov Dmitry, Musharova Olga, “Turbulence and coherent structures in Shmakov Sergey, Isaev Artem, Panov integral and non-integral systems”), Maksim, Frolov Aleksey.

Grant portfolio, mln Rub

74.4 CDISE 114.2 25.4 CLS 105.3 CNBR 6.0 CDMM 6.0 3.5 20.5 CHR 30.0 SC 10.4 30.1 CEST 189.9 34.0 CPQM 44.5 CAS 131.0 CEI 10.0 GCF 6.0

Grant portfolio as of Jan 1, 2018 Grant portfolio as of March, 2019

62 The chart presents grant portfolio, e.g. total amount of funds secured for the upcoming period.

ANNUAL REPORT // SKOLTECH Skoltech continued a range of internal re- the cross-CREI Biomedical Initiative designed to search initiatives. The Next Generation Program get ready for collaboration with Moscow Interna- (NGP) projects were carried out in a broad range tional Medical Cluster Skolkovo. The results were of areas by Skoltech faculty and their MIT peers presented at the 3rd Annual Skoltech – MIT Con- resulted in joint papers in high impactful jour- ference “Collaborative Solutions for Next Genera- nals (Nature Biotechnology, Nature Physics, tion Education, Science and Technology”. Science, etc.), invention disclosures, students’ The highlights of the CREIs research are pre- internships. Four projects were supported within sented further.

KEITH STEVENSON, Associate Provost and Dean of Research: “The third annual MIT-Skoltech conference was structured predominately around 19 fund- ed projects that support peer-to-peer and faculty-to-faculty research relationships. MIT remains a key partner and continues to develop strong relationships with Skoltech.” 63

/02 ACADEMIC & TECHNOLOGY EXCELLENCE CENTER FOR COMPUTATIONAL AND DATA-INTENSIVE SCIENCE AND ENGINEERING

Director Prof. Maxim Fedorov

Human Capital 2018 Overall research performance20 (2015 – 2018)

Faculty 23 Scholarly Output 299

Postdocs & 67 Researchers Citation Count 2246 Engineers & 49 Citations per Publication 7.5 Technical staff Students under 308 Field-Weighted Citation Impact 1.96 supervision Graduates 63

Papers in collaboration (2015 – 2018)

International collaboration 44%

Papers by subject area (2015 – 2018)

Computer Science Mathematics Chemistry Physics and Astronomy Engineering Materials Science Biochemistry, Genetics and Molecular Biology Neuroscience Other

64 20 Data on publication output in the CREIs is extracted from SciVal (as of March 1, 2019).

ANNUAL REPORT // SKOLTECH Key results 2018 CDISE is leading in the area of development The strategic plan of CDISE is to become of AI/Big Data-focused computational systems a national leader in HPC/AI and Big Data. and algorithms. The Center hosts and Another strategic area of CDISE is maintains all major HPC/Big Data installations application of AI and Big Data techniques in Skoltech. In accordance to its strategic in Internet of Things and Wireless development plan, CDISE team has recently Communications. As was noted earlier, CDISE (November 2018) installed the first AI-HPC has been recognized as national leader in these cluster in Russia, “Zhores”. The system has areas and awarded a large (1 bln RUB) grant a novel hybrid architecture specifically from National Technology Initiative Platform designed for AI&Big Data tasks and in terms for setting up National Centre of Competence of computing power it is currently #6 in Russia. in these areas (led by Prof. Lakontsev).

The main results of the CREI are as follows: Mytishi and Kazan Russia for developing deep neural networks. • Biomedicine: development of machine learning (ML) approaches for the analysis • Digital Pharma: a significant progress has of biomedical data, e.g. 2D and 3D medical been achieved in ML and MM applications images, have been elaborated. Provisional for the discovery and development of new clinical testing of these new methods has bioactive compounds with requested prop- been performed; the latter was accompanied erties (including prediction of their toxicity). by implementation of elements of new These results led to launching a start-up computational techniques for advanced company “Syntelli”. biomedical methods, e.g. high-resolution MRI. • E-Sports: several problems of automated • Digital Agriculture: new approaches and scene recognition with the use of ML as well as algorithms based on mathematical modelling implementation of Artificial Intelligent Agents (MM) and ML have been developed for the for games-related applications have been application in smart agriculture, with the solved. CDISE researchers designed advanced focus on yield prediction, smart soil analysis architecture for data collection systems and in- and remote observation of plant fields. vestigation on the problems of sensors connec- tivity, synchronization, and sensor fusion. Two • Computer vision and visual analytics: a set E-Sports-oriented startups – “Head Kraken” and of new technologies, namely, the auto- “E-sports academy LLC” have been launched. segmentation of complex scenes, analysis of 3D/4D images has been elaborated and • Internet of Things: New non-orthogonal provisionally tested during the projects coding schemes for mMTC scenarios of supported by Aeronet platform of National 5G were developed, which is especially Technology Initiative. These technologies important in the context of massive Internet include: (i) Urban Analytics project – of Things applications; the approach allows models for buildings instance segmentation to significantly improve the performance of and height estimation, models for buildings 5G LDPC codes for short length regime. classification by type; (ii) Emergency mapping project – algorithm for analyzing • Mobile Devices: a new algorithm based on satellite images of areas affected by fires tensor decompositions has been developed and other natural disasters; (iii) Training for compression of deep neural networks dataset with more than 20 000 objects without loss of accuracy; this provides a great of 5 classes labeled on VHR satellite and potential impact for mobile applications, aerial images for territory of California US, where the memory and flops are crucial. 65

/02 ACADEMIC & TECHNOLOGY EXCELLENCE • Automated Machine Learning: a family jointly with IEEE International Conference on of algorithms and software have been Data Mining series ICDM 2018. The ICDM developed that automatically construct ma- has established itself as the world’s premier chine-learning models of interatomic interac- research conference in data mining. The tion on-the-fly, reducing by tens to hundreds workshop had high international impact and time the manual work, traditionally required increased visibility of Skoltech. for constructing such models. The results open new avenues for AI-based technologies CDISE faculty received a number of national in many areas, from financial sector to pre- and international awards, including RF dictive technical maintenance in aerospace Presidential Award in Science &Innovation, and oil&gas industry. Scopus Russia Award 2018, International Digital Signal Processing Society award. • Mathematical Modelling: a number of Prof. Ivan Oseledets received a SIAM award fundamental results were obtained in mod- for Outstanding Paper prize in 2018 and elling of granular flows, nonlinear plasma, Huawei award on best project implemented and soft matter systems. Some of these in production; several prize-winning awards results have been disseminated through have been obtained by CDISE members national and international mass media, see (mostly from the group of Prof. Evgeny e.g. https://phys.org/news/2018-01-team- Burnaev) on hackathons and competitions mysteries-saturn.html (International Data Science Game in Paris, International anomaly detection contest, CDISE researchers publish papers in most Cyber security contest, etc.). prestigious journals in the field highest( rate of Q1 publications on AI/Big Data-related CDISE is involved in world-wide scientific col- topics in Russia) and present their results laborations with many leading research institutes on most prestigious international conferences (largest in Russia and abroad. Among these are the fol- number of papers presented on A/A* conferences in lowing: MIT and TUM, Technion, Tel-Aviv univer- AI/Big Data among Russian research and educational sity, University of Maryland, Ecole Polytechnique organizations). Among the most notable conference Paris, WIAS Berlin, Poznan University of Econom- papers – a breakthrough paper in deep learning in ics and Business, Boston University, University of CVPR by Prof. Victor Lempitsky and PhD student Leicester, Potsdam University, University of Oulu, Dmitry Ulyanov already cited 93 times; another Moscow State University, High School of Eco- paper with Valentin Khrulkov published in ICLR nomics, Ioffe Institute of RAS, National Research 2018, cited 20 times. Centre “Kurchatov Institute”, Taiwan Technological University, Institute of Catalysis of the Siberian Prof. Andzej Cichocki, Prof. Evgeny Burnaev, Section of RAS, Ohio State University, University Prof. Ivan Oseledets, Prof. Alexander Bernstein of Geneve, Stanford University and others. and Prof. Dmitry Dylov won the competition and were invited to organize the International CDISE is also active in developing professional Workshop on “Deep Learning and Tensor/ education courses for leading Russian Matrix Decomposition for Applications in Neu- companies including Gazpromneft and roscience” in November 2018 in Singapore Sberbank.

MAXIM FEDOROV, professor, Director CDISE: “Our center solves a broad range of interdisciplinary problems at a juncture with machine learning, artificial intelligence, data science and mathematical modeling. The idea to create a powerful, energy-efficient supercomputer with a hybrid architecture specially for machine learning and simulation based on data was conceptualized in 2017 as an answer to modern challenges in these fields. We hope that our creation of a modern computing infrastructure will help develop cooperation between Skoltech and a whole range of 66 high-technology companies that are Skolkovo residents.”

ANNUAL REPORT // SKOLTECH CDISE Director Maxim Fedorov handing over the symbolic key to the supercomputer to Nobel laureate Zhores Alferov (1930-2019)

Zhores Supercomputer housed in Skoltech 67

/02 ACADEMIC & TECHNOLOGY EXCELLENCE CENTER FOR LIFE SCIENCES

Director Prof. Konstantin Severinov

Human Capital 2018 Overall research performance (2015 – 2018)

Faculty 13 Scholarly Output 304 Postdocs & 33 Researchers Citation Count 2927 Engineers & 7 Citations per Publication 9.6 Technical staff Students under 149 Field-Weighted Citation Impact 1.76 supervision Graduates 44

Papers in collaboration (2015 – 2018)

International collaboration 44%

Papers by subject area (2015 – 2018)

Biochemistry, Genetics Multidisciplinary and Molecular Biology Chemical Engineering Chemistry Pharmacology, Medicine and Phatmaceutics Immunology and Neuroscience Microbiology Engineering Physics and Astronomy Environmental Science Agricultural and Biological Science Other 68

ANNUAL REPORT // SKOLTECH Key results 2018 Functional and comparative genomics 4) Holospora are bacterial endosymbionts liv- ing in the nuclei of cililate infusoria. Sequenc- 1) It was demonstrated that the desicca- ing and genome annotation of a member of tion-rehydration cycle in a unique object, this genus and its comparison with other African midge surviving 97% dehydration, is Holospora genomes resulted in description of regulated by the transcription factor Hsf that the Holospora metabolic features and iden- in other insects is the heat shock response tification of Holospora-specific genes likely factor. This is an example of evolutionary ex- responsible for its unique lifestyle. haptation of an existing mechanism for a new task. The study combined generation of large- scale transcriptomic data, bioinformatic analy- Adaptive bacterial immunity CRISPR-Cas systems sis (performed by Skoltech researchers), and experimental validation of specific predictions. Ongoing work on basic biology of CRISPR and their practical use by the Severinov group result- 2) The lactose operon of Escherichia coli is ed in several publications in top scientific jour- a textbook example of an operon that once nals. Research in this direction is supported by a earned its discoverers, Jacob and Monod, large MES subsidy, a contract from JSC Biocad, the Nobel prize. Nobody has suspected that Skoltech NGP and SBI and several RFBR grants. E. coli might have an additional lactose The patent rights of Skoltech for prior inventions degradation locus. A study with participa- of Severinov group have been secured. tion of Prof Mikhail Gelfand and his group showed that the locus initially described as Antibiotics involved in the sulphoquinovase catabolism indeed is involved in lactose utilization. An Structural and functional analysis of bio- interesting twist is that several co-authors synthesis of several novel oxazole-thiazole have been high school students at the time containing antibacterial peptides carried out of the research. by Severinov group and published in top in- ternational journals (JACS, Mol. Cell). 3) Bacterial species are routinely defined A new high throughput platform for screening using arbitrary criteria such as 97% identity of antibiotic producers in complex microbiota of 16S rRNA. A study with participation of samples carried out by Severinov group in Prof Mikhail Gelfand and his group suggested collaboration with RAS Institute of Bioorganic a new, evolutionarily meaningful definition Chemistry scientists (published in PNAS). of bacterial species based on identification of Sergiev’s group successfully applied CRIS- monophyletic, species-specific components PR-Cas9 genome engineering method to of pan-genomes. Application of this criterion make cell and mouse lines deficient in several resulted in identification of cryptic species RNA methyltransferase genes. Additionally, currently lumped under Prochlorococcus they studied a functional role of the small marinus, the latter being the most important mammalian mitochondrial peptide, overlooked source of oxygen. by genome annotation.

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/02 ACADEMIC & TECHNOLOGY EXCELLENCE Teaching lab at Skoltech Center for Life Sciences

70 Teaching lab at Skoltech Center for Life Sciences

ANNUAL REPORT // SKOLTECH Notable publications (in journals with IF ≥ 10), students are marked by *:

Davey, M. S., C. R. Willcox, S. Hunter, S. ing as a transcription elongation roadblock.” A. Kasatskaya*, E. B. M. Remmerswaal, M. Nucleic Acids Res 46(20): 10810-10826. Salim, F. Mohammed, F. J. Bemelman, D. M. Journal Impact Factor 10.162 Chudakov, Y. H. Oo and B. E. Willcox (2018). “The human Vδ2(+) T-cell compartment com- Krivoy, A.*, M. Rutkauskas, K. Kuznedelov, prises distinct innate-like Vγ9(+) and adaptive O. Musharova, C. Rouillon, K. Severinov and Vγ9(-) subsets.” Nat Commun 9(1): 1760. R. Seidel (2018). “Primed CRISPR adaptation Journal Impact Factor 12.353 in Escherichia coli cells does not depend on conformational changes in the Cascade Ferreira, P. G., M. Munoz-Aguirre, F. Reverter, effector complex detected in Vitro.” Nucleic C. P. Sa Godinho, A. Sousa, A. Amadoz, R. Acids Res 46(8): 4087-4098. Journal Impact Sodaei, M. R. Hidalgo, D. Pervouchine, J. Factor 10.162 Carbonell-Caballero, R. Nurtdinov, A. Breschi, R. Amador, P. Oliveira, C. Cubuk, J. Curado, Radovcic, M., T. Killelea, E. Savitskaya, F. Aguet, C. Oliveira, J. Dopazo, M. Sammeth, L. Wettstein, E. L. Bolt and I. Ivancic-Bace K. G. Ardlie and R. Guigo (2018). “The (2018). “CRISPR-Cas adaptation in Esche- effects of death and post-mortem cold isch- richia coli requires RecBCD helicase but not emia on human tissue transcriptomes.” Nat nuclease activity, is independent of homolo- Commun 9(1): 490. Journal Impact Factor gous recombination, and is antagonized by 12.353 5’ ssDNA exonucleases.” Nucleic Acids Res 46(19): 10173-10183. Journal Impact Factor Hu, H., J. M. Liu, Z. Hu, X. Jiang, X. Yang, J. 10.162 Li, Y. Zhang, H. Yu and P. Khaitovich (2018). “Recently Evolved Tumor Suppressor Tran- Sergiev, P. V., N. A. Aleksashin, A. A. Chu- script TP73-AS1 Functions as Sponge of Hu- gunova*, Y. S. Polikanov and O. A. Dontsova man-Specific miR-941.” Mol Biol Evol 35(5): (2018). “Structural and evolutionary insights 1063-1077. Journal Impact Factor 10.217 into ribosomal RNA methylation.” Nat Chem Biol 14(3): 226-235. Journal Impact Factor Hunter, S., C. R. Willcox, M. S. Davey, S. A. 13.843 Kasatskaya*, H. C. Jeffery, D. M. Chudakov, Y. H. Oo and B. E. Willcox (2018). “Human Travin, D. Y., M. Metelev, M. Serebryako- liver infiltrating gammadelta T cells are com- va, E. S. Komarova*, I. A. Osterman, D. posed of clonally expanded circulating and Ghilarov and K. Severinov (2018). “Biosyn- tissue-resident populations.” J Hepatol 69(3): thesis of Translation Inhibitor Klebsazolicin 654-665. Journal Impact Factor 14.911 Proceeds through Heterocyclization and N-Terminal Amidine Formation Catalyzed Khrameeva, E., I. Kurochkin*, K. Bozek, P. by a Single YcaO Enzyme.” J Am Chem Soc Giavalisco and P. Khaitovich (2018). “Lipi- 140(16): 5625-5633. Journal Impact Factor dome Evolution in Mammalian Tissues.” Mol 14.357 Biol Evol 35(8): 1947-1957. Journal Impact Factor 10.217 Yu, Q., Z. He, D. Zubkov*, S. Huang, I. Kurochkin*, X. Yang, T. Halene, L. Willmitzer, Klimuk, E., E. Bogdanova, M. Nagornykh, P. Giavalisco, S. Akbarian and P. Khaitovich A. Rodic, M. Djordjevic, S. Medvedeva*, O. (2018). “Lipidome alterations in human pre- Pavlova and K. Severinov (2018). “Controller frontal cortex during development, aging, and protein of restriction-modification system cognitive disorders.” Mol Psychiatry. Journal Kpn2I affects transcription of its gene by act- Impact Factor 11.64 71

/02 ACADEMIC & TECHNOLOGY EXCELLENCE CENTER FOR DESIGN, MANUFACTURING AND MATERIALS

Director Prof. Iskander Akhatov

Human Capital 2018 Overall research performance (2015 – 2018)

Faculty 7 Scholarly Output 123 Postdocs & 14 Researchers Citation Count 348 Engineers & 17 Citations per Publication 2.8 Technical staff Students under 57 Field-Weighted Citation Impact 0.92 supervision Graduates 8

Papers in collaboration (2015 – 2018)

International collaboration 50%

Papers by subject area (2015 – 2018)

Engineering Computer Science

Materials Science Earth and Planetary Science Physics and Astronomy

Energy Chemical Engineering

Mathematics Other

72

ANNUAL REPORT // SKOLTECH Key results 2018 • Several excellent faculty, researchers, approved by the National Technology and postdoctoral students have been recruit- Initiative office (Technet) with the funding ed. Five research laboratories have been es- planned for 2018 – 2020. tablished: Composite Materials and Structures Laboratory, Additive Manufacturing Laborato- • Project «Development of industrial ry, Mechanical Testing and Materials Charac- production technology of lightweight perforat- terization Laboratory, Information Technologies ed honeycomb core aluminum foil structures for Advanced Manufacturing Laboratory, and for spacecraft» is being executed according to Micro- and Nano-Mechanics Laboratory. the Contract with JSC ISS Reshetnev. This is first successful experience in developing R&D • Two synergetic educational programs collaboration with Russian High-Tech Industry. have been developed and fully accredited: MSc program in Advanced Manufacturing Technolo- • Skoltech-Oerlikon Additive Manufacturing gies and PhD in Mathematics and Mechanics. Laboratory has been established in 2018. Full curriculum for these programs consisting The Cooperative Research Agreement and of over 20 MSc and PhD level courses, taught Contract with Oerlikon have been signed. Oer- by CDMM faculty, is developed. The number of likon is going to fund three research projects PhD (MS) students has steadily grown. over three years (2018 – 2020) with total funding 864 000 Euro, cover basic charges • Several R&D initiatives and industrial for rent and furniture with total funding 164 projects are launched and/or executed by 000 Euro. On top of this Oerlikon is going the Center with two highly visible profes- to contribute to the joint laboratory with the sional advisory services initiatives currently equipment for a total of about 1 mln Euro.

73

/02 ACADEMIC & TECHNOLOGY EXCELLENCE 74 CDMM Additive Manufacturing Laboratory (high tech 3D printing equipment)

ANNUAL REPORT // SKOLTECH CDMM Laboratory of Cyber Physical Systems

CDMM Mechanical Testing Laboratory 75

/02 ACADEMIC & TECHNOLOGY EXCELLENCE CENTER FOR HYDROCARBON RECOVERY

Director Prof. Mikhail Spasennykh

Human Capital 2018 Overall research performance (2015 – 2018)

Faculty 13 Scholarly Output 120 Postdocs & 22 Researchers Citation Count 163 Engineers & 22 Citations per Publication 1.4 Technical staff Students under 94 Field-Weighted Citation Impact 0.62 supervision Graduates 7

Papers in collaboration (2015 – 2018)

International collaboration 17%

Papers by subject area (2015 – 2018)

Energy Engineering

Earth and Planetary Science Chemical Engineering

Physics and Astronomy Environmental Science

Chemistry Materials Science

76

ANNUAL REPORT // SKOLTECH Key results 2018 • CHR commissioned and maintains running • In 2018, CHR has significantly expanded 24/7 a state-of-the-art laboratory with a its industrial R&D program. By year end, world class equipment for development, the portfolio included 45 contracts with testing and validation of new technologies total funding exceeding 380M Rub. for exploration and production of uncon- ventional and hard to recover hydrocarbon • CHR research results have been presented reserves. Several unique experimental in more than 100 industry research reports, setups were installed and commissioned and the related scientific results were pub- in 2018, such as X-ray micro-CT scanner lished in more than 150 research papers, with incorporated high-pressure and most of which are indexed in Scopus, Web high-temperature filtration system, and of Science, and One Petro (the major data high-pressure high-temperature miscible base covering publications in areas related gas core flood system and other. to oil and gas exploration and production).

77

/02 ACADEMIC & TECHNOLOGY EXCELLENCE Hydrocarbon Recovery laboratory

78 Hydrocarbon Recovery laboratory

ANNUAL REPORT // SKOLTECH Hydrocarbon Recovery laboratory

Hydrocarbon Recovery laboratory 79

/02 ACADEMIC & TECHNOLOGY EXCELLENCE SPACE CENTER

Director Prof. Anton Ivanov

Human Capital 2018 Overall research performance (2015 – 2018)

Faculty 6 Scholarly Output 60 Postdocs & 7 Researchers Citation Count 162 Engineers & 5 Citations per Publication 2.7 Technical staff Students under 94 Field-Weighted Citation Impact 1.28 supervision Graduates 18

Papers in collaboration (2015 – 2018)

International collaboration 53%

Papers by subject area (2015 – 2018)

Engineering Mathematics

Computer Science Decision Science

Earth and Planetary Science Other

Physics and Astronomy

80

ANNUAL REPORT // SKOLTECH Key results 2018

In 2018 the Space Center has advanced its projects in its three key areas, with focus on collab- orations in Europe and Russia. Development focus was on industrial projects, which can benefit from the Center’s experience in systems engineering.

Strategic Thinking Advanced engineering

• The Concurrent Design Engineering Lab • The Satellite Technology Lab has initiated a performed business case studies for project on swarm satellite systems. Im- Russian industry and external customers. portant stakeholders were identified and Industrial studies included preparation of preliminary requirements for the project a financial assessment for a worldwide were drafted. Planned launch for the first internet distribution from space assets. prototype is targeted 2020. Key partners Study report was used when laying plans are RosCosmos, Moscow State University, for a future Russian national constellation. Tomsk Polytechnic Universtiy, Far East Space advertisement business case was Federal University. evaluated for a commercial customer, thus celebrating the first paid study in CEDL. • The robotics group has demonstrated Methodology and key results were present- a number of technologies at IROS confer- ed at the International Astronautical Union ence, including swarm of drones, featured in Bremen (IAC 2018). later in IEEE publication.

• Lunar project of a small science satellite was completed with consortium of universi- Applications ties including PolyMilan, TU Delft and European Space Agency. • Prof. Podladchikova has received a highly competitive H2020 grant as a part of con- • Active debris removal (ADR) from congested sortium (led by TU Graz, Austria) studying orbits is a solution to pollution of space. space weather. The Space Center participates jointly with Ecole Polytechnique Federale de Lausanne • A number of industrial contracts was started, (EPFL) in preparation of a strategy to including application of hyperspectral remote finance ADR service. sensing to forest taxation (with Perm Uni- versity) and creation of distributed ground • The research project for Airbus provides stations for satellite telecommunications support for the corporate technology (with Samara Universtiy). These projects are roadmapping to maximize the potential supporting a country wide program “Planet return of Research and Technology Watch” to attract companies and students investments through optimization of prod- to utilization of data from space services ucts and services in the group. The proj- (remote sensing, navigation, telecommunica- ect is set to complete in 2019 to provide tions). This program is supported by “Talents recommendations to improve corporate and Success” Foundation, Foundation to sup- bottom line. port innovations (Bortnik) and RosCosmos.

81

/02 ACADEMIC & TECHNOLOGY EXCELLENCE SC Intelligent Space Robotics Laboratory

82 SC Intelligent Space Robotics Laboratory

ANNUAL REPORT // SKOLTECH SC Intelligent Space Robotics Laboratory

SC Intelligent Space Robotics Laboratory 83

/02 ACADEMIC & TECHNOLOGY EXCELLENCE CENTER FOR ENERGY SCIENCE AND TECHNOLOGY

Director Prof. Keith Stevenson

Human Capital 2018 Overall research performance (2015 – 2018)

Faculty 21 Scholarly Output 338 Postdocs & 43 Researchers Citation Count 3145 Engineers & 6 Citations per Publication 9.3 Technical staff Students under 138 Field-Weighted Citation Impact 1.87 supervision Graduates 14

Papers in collaboration (2015 – 2018)

International collaboration 69%

Papers by subject area (2015 – 2018)

Chemisty Computer Science

Materials Science Mathematics Physics and Astronomy Multidisciplinary Engineering Biochemistry, Genetics Energy and Molecular Biology

Chemical Engineering Other 84

ANNUAL REPORT // SKOLTECH Key results 2018 Over 167 publications indexed in Web of Science were published or in press in high impact factor journals. 61% of these publications are published in the top 10% of journals worldwide.

• “The Role of Semilabile Oxygen Atoms oped a novel approach to power system for Intercalation Chemistry of the Metal-Ion operation when using electrochemical Battery Polyanion Cathodes,” Tereshchen- batteries. ko, I.V., Aksyonov, D.A., Drozhzhin, O.A., Presniakov, I.A., Sobolev, A.V., Zhuga- • “2D materials worth their salt,” Oganov, yevych, A., Striukov, D., Stevenson, K.J., A.R. 2018 Nature Chemistry with a field Antipov, E., Abakumov, A.M. 2018 Journal weighted citation index of 28; and “Accel- of the American Chemical Society with a erating high-throughput searches for new field weighted citation index of 15. alloys with active learning of interatomic potentials,” Gubaev, K., Podryabinkin, E.V., • Developed detailed techno-economic Hart, G.L.W., Shapeev, A.V.2019 Com- models of Li-ion batteries (Gonzalez, putational Materials Science with a field Bischi, Pozo) In this research it is devel- weighted citation index of 34.38

85

/02 ACADEMIC & TECHNOLOGY EXCELLENCE CEST Energy Storage Laboratory

86 CEST Energy Storage Laboratory

ANNUAL REPORT // SKOLTECH CEST Energy Storage Laboratory

CEST Energy Storage Laboratory 87

/02 ACADEMIC & TECHNOLOGY EXCELLENCE CENTER FOR PHOTONICS & QUANTUM MATERIALS

Director Prof. Franko Kueppers

Human Capital 2018 Overall research performance (2015 – 2018)

Faculty 15 Scholarly Output 203 Postdocs & 29 Researchers Citation Count 975 Engineers & 14 Citations per Publication 4.8 Technical staff Students under 93 Field-Weighted Citation Impact 1.00 supervision Graduates 14

Papers in collaboration (2015 – 2018)

International collaboration 84%

Papers by subject area (2015 – 2018)

Physics and Astronomy Multidisciplinary

Materials Science Biochemistry, Genetics and Molecular Biology Engineering Chemistry Mathematics

Chemical Engineering Other

88

ANNUAL REPORT // SKOLTECH Key results 2018

Over 50 plenary and invited talks were given at international conferences. The main scientific achievements are as follows:

• A Charge Quantum Interference Device • A new approach for detection of (CQUID) complementary to SQUID is im- degradation drug delivery carriers in vivo plemented for the first time. A new device by fluorescent tomography has suggested. is based on coherent tunneling of vortices It allows us to realize remote-controlled across a dirty superconducting wire. release of bioactive substances under CQUID may be used for a future quantum control of fluorescent tomography in vivo current standard (V. Antonov) (Nature (D. Gorin). Physics) • Spin polarization switching in polariton • The light-induced melting of a charge condensates in an optical trap was density wave is investigated by time-resolved achieved via illumination with laser light probes. Re-establishment of phase coher- (P. Lagoudakis). ence is associated with annihilation of topo- logical defects (B. Fine) (Nature Physics) • New designs allowing predominant emission of circularly polarized light from • A novel wet pulling technique to fabricate an unpolarized source in the absence of carbon nanotube fibers is developed. The an external magnetic field are suggested method is easily adaptive to different kinds (N. Gippius). of carbon nanotubes and allows rapid fab- rication of both active and passive flexible • The response of a superconductor to electronic components (A. Nasibulin). a weak microwave signal is calculated at arbitrary temperatures and radiation • The design of passive and active frequencies. The approach generalizing components of microwave photonics based the old Eliashberg theory meets the needs on Si/ITO structures have been developed of modern superconducting applications (V. Drachev). (M. Skvortsov).

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/02 ACADEMIC & TECHNOLOGY EXCELLENCE CPQM Laboratory of Nanomaterials

90 CPQM Laboratory of Nanomaterials

ANNUAL REPORT // SKOLTECH CPQM Laboratory of Nanomaterials

CPQM Laboratory of Nanomaterials 91

/02 ACADEMIC & TECHNOLOGY EXCELLENCE CPQM Hybrid Photonics Laboratories

92 CPQM Hybrid Photonics Laboratories

ANNUAL REPORT // SKOLTECH CPQM Hybrid Photonics Laboratories

CPQM Hybrid Photonics Laboratories 93

/02 ACADEMIC & TECHNOLOGY EXCELLENCE CENTER FOR ADVANCED STUDIES

Director Prof. Igor Krichever

Human Capital 2018 Overall research performance (2015 – 2018)

Faculty 18 Scholarly Output 42 Postdocs & Researchers 8 Citation Count 58 Students Citations per Publication 1.54 supervised 33

Graduates 2018 7 Field-Weighted Citation Impact 0.87

Papers in collaboration (2015 – 2018)

International collaboration 76%

Papers by subject area (2015 – 2018)

Mathematics

Physics and Astronomy

Computer Science

Other 94

ANNUAL REPORT // SKOLTECH Key results 2018 In 2018, the research achievements of CAS members and students were recognized by the awards (Prof. M. Finkelberg, Roman Gonin, Prof. Mikhail Bershtein) Igor Makhlin is a winner of “Young Russia Mathematics” prize for young researches.

Over 25 publications indexed in Web of O. V. Ogievetskii, S. B. Shlosman, “Plane Science were published in high impact factor Partitions and Their Pedestal Polynomials”, journals in 2018 and 30 preprints prepared. Mat. Zametki, 103:5 (2018), 745–749 Selected examples include:

M. Bershtein, P. Gavrylenko, A. Marshakov, CAS faculty are highly visible organizers “Cluster integrable systems, q-Painleve and participants in international conferences equations and their quantization”, J. High (over 50 invited talks). In 2018, Energ. Phys. (2018) 2018: 77 the following conferences and workshops were organized: M. Finkelberg, J. Kamnitzer, K. Pham, L. Rybnikov, A. Weekes, “Comultiplication Research Meeting “Infinite Dimensional for shifted Yangians and quantum open Algebras, Geometry and Integrable Systems”, Toda lattice”, Adv. Math. 327 (2018) 349-389 November 1-6, 2018 / Kyoto, Japan Moscow-Pisa Colloquium, October 1-5, 2018; A. A. Gaifullin, Y. A. Neretin, “Infinite International conference “Topology and symmetric group, pseudomanifolds, and Physics”, September 5-6, 2018; combinatorial cobordism-like structures”, International Conference “Conformal Field J. Topol. Anal., 10(3) 605-625 (2018) Theories in Higher Dimensions”, August 6-17, 2018; A. Liashyk, N. A. Slavnov, “On Bethe vec- Pre-CQIS Summer School on Theoretical and tors in gl3-invariant integrable models”, Mathematical Physics, June 25-30, 2018 J. High Energ. Phys. 6 (2018) 018 6th Workshop “Combinatorics of Moduli Spaces, Cluster Algebras, and Topological A. Losev, I. Polyubin, A. Rosly, “Ultraviolet Recursion” June 4-9, 2018; Properties of the Self-Dual Yang-Mills Theory”, Conference “Algebraic Topology, Combina- J. High Energ. Phys. (2018) 2018: 41 torics, and Mathematical Physics”, May 24–30, 2018; M. Semenyakin, G. Falkovich, “Alternating Third school-conference “String Theory, currents and shear waves in viscous electronics”, Integrable Models and Representation Phys. Rev. B 97, 085127 (2018) Theory”, Moscow, January 21 – 27, 2018.

MIKHAIL BERSHTEIN, Associate Professor at Skoltech, winner of the 2018 Moscow Government Award for Young Scientists: “Skoltech has a lot of bright students that inspire you to hone your skills and learn new things.” 95

/02 ACADEMIC & TECHNOLOGY EXCELLENCE Igor Krichever, Professor, Director of Skoltech Center for Advanced Studies, at the conference “Algebraic Topology, Combinatorics, and Mathematical Physics” (May, 2018)

96 At the conference “Algebraic Topology, Combinatorics, and Mathematical Physics” (May, 2018)

ANNUAL REPORT // SKOLTECH At the conference “Algebraic Topology, Combinatorics, and Mathematical Physics” (May, 2018)

At the conference “Algebraic Topology, Combinatorics, and Mathematical Physics” (May, 2018) 97

/05 TARGET DOMAINS AND CREIs Research Infrastructure

The Institute’s research infrastructure is a dynamic and vibrant part of development, the year was marked with establishing new laboratories as well as expansion of existing ones.

Data Science & Artificial Intelligence • Several state of the art HPC clusters were installed. One of these is our flagship (AI-HPC) cluster for artificial intelligence and data-driven modeling “Zhores”, which boasts 0.5 Pflop/s performances (#6 in Russia) – a supercomputer with special- ized architecture (104 NVIDIA Tesla V100 GPUs) tailored for deep learning applications.

Life Sciences & Health • Teaching Lab (Technopark) became operational. This lab enables delivery of two practical teaching courses (core curriculum of the CLS educational programs) and also allows limited research activity of CLS faculty members.

Cutting-edge Engineering & • Composite Materials and Structures Laboratory, Advanced Materials Additive Manufactur-ing Laboratory, Mechanical Testing and Materials Characterization Laboratory, Cyber-Physical Laboratory, and Micro- and Nano-Me- chanics Laboratory (CDMM) became fully operational. • Laboratory of unconventional petrophysics, Laboratory of reservoir geochemistry, Laboratory of geomechanics, Laboratory of enhanced oil recov- ery (chemical, thermal, gas and hybrid methods), Laboratory of gas hydrates and permafrost (CHR) became fully operational (Renova Lab building). • Robotics lab invested heavily in precise positioning systems to control drones and other robots (SC).

Energy Efficiency • Smartgrids Lab for testing microgrid novel control technologies • Thermal Lab for hardware study the meteorological impacts on the reliability of overhead power lines • Computational facilities • Pilot scale facility for solution chemistry and hydrothermal synthesis of cathode materials (LFP, LFMP, NMC) in small kg batch quantities • Dielectric Lab for experiments to elucidate the fundamental atomic-molecular mechanisms of ionic transport and charge separation • Indoor Microclimate Lab (Polygon room) serves as the data acquisition system to control room cli- mate in an energy efficient way and test optimized control strategies.

Photonics & Quantum Materials • Nanoplasmonics Lab (V. Drachev) (under installation) . • Biophotonics Lab (D. Gorin) (under development) • Time and Frequency Research (Atomic Clock) 98 laboratory (under development)

ANNUAL REPORT // SKOLTECH Skoltech Shared Facilities were further developed to support the Institute in performing cutting-edge basic and applied research as well as delivering educational excellence. With over seven state-of-the art laboratories stretched across more than 10 000 sq. meters, when fully relocated and started up in Campus, Skoltech shared facilities will generate value and bring expertise to internal as well external customers and partners.

Advanced Imaging Core Facility FabLab and Machine Shop Shared Facility

FabLab and Machine Shop Shared Facility FabLab and Machine Shop Shared Facility​ 99

/02 ACADEMIC & TECHNOLOGY EXCELLENCE In 2018 Skoltech established: projects were implemented at GCF, both for in- ternal and external customers. The GCF provided • Genomics Core Facility (headed by Dr. Maria regular sequencing service for biomed MSc and Logacheva); PhD students. In October 2018, the Facility • FabLab and Machine Shop (headed by participated in the program of large research Vladimir Kalyaev); infrastructure facilities organized by RSF and re- • Advanced Imaging Core Facility (headed by ceived 24 applications from potential customers. Prof. Artem Abakumov); • Micro- and Nanofabrication Cleanroom FabLab and Machine Shop Shared Facility (headed by Prof. Vladimir Antonov); (FabLab) was established in October 2018 • BioImaging and Spectroscopy Core Facility based on Student Masterskaya. The Facility (headed by Prof. Dmitry Gorin). is equipped with a wide range of machines, tools, and technological chains to fabricate, Shared Facilities Development Plans, spec- analyze, repair, and improve broad range of ifying equipment, space, staffing structure, as materials, parts and pieces. The precision well as planned budget were developed and quality of certain characterization tools is presented to the Academic Council. Each Fa- better than 2um. Professional quality rapid cility established its Expert Council (governing manufacturing and technical consulting are committee) presented by Skoltech and exter- the key features to succeed in both research nal experts, who provide recommendations and educational activities. Unlike external on issues of strategic planning (focus areas, facilities, for requests of moderate complexity infrastructure, services). FabLab and Machine Shop Shared Facility As of December 2018, Genomics, FabLab operates on the “next day delivery” principle, and Machine Shop, BioImaging and Spectros- bringing researchers, industry and students copy were fully functional at Skoltech interim flexibility when planning their activities. campus. Advanced Imaging, Micro-and Nano- FabLab was actively involved in education, fabrication Cleanroom would start their opera- providing working space, personnel, tools, ma- tions in Campus directly. The establishment of chines and all supplies necessary for student Advanced Mass Spectrometry was in progress. courses; R&D works for both internal and ex- ternal customers, ranging from the consulting Genomics Core Facility (GCF), was es- stage to implementation of customer ideas tablished in March 2018 by spun off from based on knowledge and experience of Facility the CLS, to coordinate and support genomic staff; manufacturing; hosting competitions and research programs carried out by Skoltech hackathons; supporting start-up companies. researchers, participants of Skolkovo eco- system as well as external customers. The Advanced Imaging Core Facility (AICF) was Facility is equipped with high-throughput Il- established in September 2018 to provide lumina sequencers HiSeq4000 and MiniSeq, top-level advanced electron microscopy ser- equipment for nucleic acid extraction, library vices to support research in both academic preparation and quality control (Illumina cBot and industrial sectors at Skoltech, within 2, Biomek NXp Span-8, Covaris M220, Bio- the Skolkovo ecosystem, and for external analyzer 2100 etc.), auxiliary sample prepara- partners. AICF is equipped with three electron tion tools as well as computational resources microscopes, including an aberration-correct- for data storage and analysis. ed FEI Titan Themis Z transmission electron microscope with a monochromated electron GCF became the Institute’s first unit and a source, Super-X system for energy-disper- model for others in terms of operation. The CLS sive X-ray analysis, a high-resolution EELS faculty along with the Shared Facilities Office spectrometer, electron tomography setup were spearheading this effort while guided by and versatile set of sample holders. Dual best international research universities practices. beam system FEI Helios G4 Plasma focused 100 Since its establishment, multiple sequencing ion beam machine and Quattro S scanning

ANNUAL REPORT // SKOLTECH electron microscope provide possibilities for BioImaging and Spectroscopy Core Facility site-specific TEM sample preparations, slice- (BISCF) was established in October 2018 and-view tomography, surface imaging, mor- to provide cutting edge technologies for in phology studies and compositional analysis. vitro/in vivo imaging and spectral analysis using photonic tools for Skoltech researchers, After starting-up in Skoltech Campus in Q1- members of Skolkovo ecosystem as well as Q2 2019, the Facility will provide services to external customers. The formation of BISCF is customers according to the highest interna- a result of collaboration between CPQM (Plas- tional standards. monics laboratory headed by Prof. Vladimir Drachev and Biophotonics laboratory headed Micro- and Nanofabrication Cleanroom by Prof. Dmitry Gorin) and CLS (Prof. Kon- (Nanofab) was further developed to sup- stantin Lukyanov and Prof. Timofey Zasepin). port high-tech R&D projects carried out by Skoltech researchers, participants of Skolkovo The expertise of BioImaging and Spectroscopy ecosystem and external customers. The Core Facility covers several fields, including pho- Facility will be equipped with nanofabrication tonic and plasmonic tools for spectroscopy and equipment of high specification and it will imaging as well as materials science, chemistry be managed by a team of experts enabling and biology for targeted delivery and biosensing. efficient research and development in the The broad range of capabilities as well as exten- fields of modern semiconductor photonics, sive experience of Facility staff allow solving wide processing of 2D materials and superconduct- variety of scientific, research and practical tasks in ing coherent circuits. The Facility is expected the fields of biology, medicine, pharmacology, cos- to start operation by the end of 2020. metology, food industry, and advanced technology. Over the course of 2018 BioImaging and Spec- The Nanofab is designed as a flexible tech- troscopy Core Facility was actively involved in R&D nological platform for fundamental research projects for both internal (Skoltech) and external and a prototype industrial manufacturing. The customers. Since its start and over the period of knowledge database will be developed as a less than two months, the Facility contributed to synergy of technological and intellectual input 1 external and 4 internal projects. The Facility from the fundamental science and indus- participated in the program of large research infra- try-oriented research. Ph.D students, postdocs, structure facilities organized by RSF and received researchers, engineers and technicians will 7 applications from potential customers. be the intellectual foundation of the Nanofab knowledge base. Facilities will be open 24/7 Identification and establishment of new shared for users, ensuring efficient usage of equip- facilities is an ongoing process, reflecting cur- ment and intensive R&D. With a world level rent and prospective needs of Skoltech CREIs in of equipment, expertise and scale Skoltech terms of acquiring research equipment as well Nanofab will respond to the need in modern as starting collaboration with academic and R&D of components for high-tech products industrial partners. In order to coordinate the as well as fundamental scientific research. Its establishment and later manage successful op- broad range of capabilities as well as extensive erations as well as oversee future development experience of Facility staff will be unique in of Skoltech Shared Facilities, Shared Facilities Russia and will allow solving wide variety of Office (headed by Dr. Alexey Denisov) was es- scientific, research and practical tasks. tablished subordinated to the Dean of Research.

MARIA LOGACHEVA, Director of Genomics Core Facility and winner of 2018 Moscow Government Award for Young Scientists: “Managing the Skoltech Genomics Core Facility sets new goals that help to broaden our horizons in genomic research and work on exciting projects. While further developing our Facility, I expect to explore new methods, such as monomolecular sequencing.” 101

/02 ACADEMIC & TECHNOLOGY EXCELLENCE Genomics Core Facility

102 FabLab and Machine Shop Shared Facility

ANNUAL REPORT // SKOLTECH FabLab and Machine Shop Shared Facility

Genomics Core Facility 103

/02 ACADEMIC & TECHNOLOGY EXCELLENCE Integrating Innovation

In pursuing its mission, Skoltech fosters and • VIP lectures from such noted personalities links education and research with innovation as Dr. Charles Cantor, a world-renowned and entrepreneurship. The overarching goal expert in biophysical chemistry; Thierry is to instill a culture of innovation and entre- Chevalier, who leads the digital design preneurship in research and education across manufacturing activities at Airbus; Simon traditional disciplinary boundaries. Bradley, Senior Vice President of Cyber Security at Siemens; renowned Finnish en- Serving as an introduction to Skoltech trepreneur, Pekka Viljakainen; and, Munich approach to education and entrepreneurship, based incubator and founder, Dr. Johann the Innovation Workshop (IW) is generally Fuller – among many others. the first course that students take when • Leadership and teamwork exercises, starting their experience at Skoltech. • English-language and presentation-skills The Innovation Workshop 2018 featured training, many new elements including, for the first • Presentations on project topics by select time, the active participation of over 30 Skoltech faculty members, international mentors and speakers; • An extensive curriculum, including the a customer-centric organizational team; “Innovating” textbook by MIT Professor Luis and, a substantial networking and social Perez-Breva, and media program. • The innovation project (one team project involving daily teamwork). During this “boot camp” style, month-long learning experience, students were challenged Student feedback about the IW is very pos- to work with technological innovation in a col- itive. Participants evaluated it as useful for laborative environment – something that is es- developing practical skills (80%). More than sential to the Skoltech reality. In 2018, more 75% of students mentioned that the atmo- than 350 incoming students learned from sphere of IW was inspiring for active learning distinguished Skoltech professors, specialists while the course content was challenging and mentors from around the world, and enough. worked under their guidance to develop the knowledge and skills essential for both their Providing hands-on experience in high-tech experience at Skoltech and the post-graduate companies for students in the middle of MSc future in their prospective career fields. programs, the Industrial Immersion resulted in 147 projects completed by 213 students Far from an abstract idea, the innovative in 102 companies such as Astra Zeneca, projects developed during the IW were BIOCAD, Bosch, British Petroleum, Deloitte, meant to tackle a “real world” problem and Gazpromneft, Google, Huawei, Lukoil, Mega- prepare students for the spirit of innovation fon, NVIDIA, Philips, Rosneft, Rostelecom, and entrepreneurship they will be immersed RusHydro, Samsung, Sberbank, Siemens, in throughout their time at Skoltech. Going Tinkoff Bank, Yandex, Zarubezhneft, and forward, students will be able to continue many others. developing their successful ideas, with the help of Skoltech. The number of student team projects grew to 21%, e.g. 8% higher than in the previous The learning of Innovation Workshop takes year. 90% of projects were located in Russia, place through a combination of: mostly in Moscow and Moscow Region, and also in Astrakhan, Krasnodar, Novosibirsk, • Quick Success projects (three one-day Saint Petersburg, Sochi, and Vladimir. Some team projects during the first week), students experience industry immersion • Morning and evening “glue lectures,” abroad – Athens, Bengaluru, Berlin, Ham- • Lectures on business fundamentals and burg, Hannover, Havana, Islamabad, Leiden, 104 innovation, Madrid, Neuchâtel, San Francisco, Sendai,

ANNUAL REPORT // SKOLTECH Stockholm, Tel Aviv, Toronto, Toulouse, Win- NVidia). For example, Samsung took the nipeg, Zurich. biggest number of Data Science students in 2018, while in the previous year among dom- Interest to host Skoltech students for industrial inated companies were Yandex, Datadvance, immersion among high-tech companies in- S7, Mimimax94. creased: 75% of companies in 2018 were new, comparing the list of 2017. For example, in Industry Day 2018, a large conference of Energy Systems educational program there was Industrial Immersion program included poster an absolutely new set of partners, compared sessions, industrial tables and seminars on with 2017 (System Operator, RusHydro, Siberi- top technological topics, with participation of an generating company, Siemens). In Materials Skoltech professors, students and representa- Science, Bosch and InEnergy were comple- tives of 110 high-tech companies. mented with 6 new companies including Liotech, the biggest on the Russian market. A Created in 2012 in collaboration with MIT, new set of strong private companies appeared Skoltech Translational Research and in Photonics, such as Skontel and Avesta. Innovation Program (STRIP) provides Skoltech startups also began to take students critical support for translational research for industrial immersion, e.g. Tsuru Robotics. and funding for Institute based early stages At the same time some programs kept is a projects. Aimed to bridge the gap between stable portfolio of partners – for the second laboratory and marketplace, and to drive year in a row Gazpromneft and Zarubezhneft innovation and entrepreneurship, the program are successfully hosting students of Petroleum supports project teams to help establish proof Engineering program for team projects. of concept and advance their technology towards commercialization, including pre- More foreign companies (R&D departments startup identification of high potential market in Russia) became partners for Industrial opportunities, intellectual property management, Immersion program (e.g. Phillips, Samsung, and, if appropriate, team development.

LAWRENCE STEIN, Vice President for International Business Affairs, Intellectual Property: “The Innovation Workshop is key to Skoltech’s mandate as an applied research institute with a strong emphasis on entrepreneurship and commercialization. In addition to our own faculty, who are supported by researchers and PhD students, this year’s workshop brings in more than 20 international mentors – providing unique perspective on how to succeed in today’s business environment.” 105

/02 ACADEMIC & TECHNOLOGY EXCELLENCE Skoltech Innovation Workshop (September 2018)

106 Skoltech Innovation Workshop (September 2018)

ANNUAL REPORT // SKOLTECH Skoltech Innovation Workshop (September 2018)

Skoltech Innovation Workshop (September 2018) 107

/02 ACADEMIC & TECHNOLOGY EXCELLENCE In 2018, the following seven projects have completed the Program 2017 – 2018:

Magic carpets • marker design / marker detection algorithm for VR applications Prof. Victor Lempitsky (CDISE) is developed • system design with a slanted mirror developed • 2 RU patents • 1 PCT application

Flexible ultrasound module • prototype of thermoacoustic ultrasound generator is developed Prof. Albert Nasibulin (CPQM) • 1 RU patent application • communication with Spetsmash, Marvel Minds

Components for stretchable • temperature sensor based on nanomaterials is developed skin-like electronics • application software is developed Prof. Albert Nasibulin (CPQM) • 1 RU patent application • communication with Star Tech Ventures

Development of new • new measuring equipment and technology for both hydrocarbon method and technology and geothermal reservoir characterization developed for investigations of traditional • 2 RU patent applications and unconventional • attracted 5,8 mln RUB from Lukoil hydrocarbon reservoirs • startup Thermal Petrophysics created and supported by FASIE Prof. Yuri Popov (CHR) (1,0 mln. RUB)

Sense2beat (previous Cardiolog) • prototype of a wearable ECG patch for cardiac arrhythmia Prof. Tatiana Podladchikova monitoring is developed (SC) • noise cancellation algorithm of an ECG signal is developed • detection algorithm of an ECG waveform characteristics for further cardiac arrhythmia analysis is developed • 3-d place in Sevan Startup Summit, awarded by the President of Armenia • Shortlisted to 100 best startups to participate in SLUSH-2018 • received Skolkovo residency • startup Sense2beat created

PickToGo: Development • prototype of robotic platform is developed of picking robotic platform • localization and navigation algorithms in dynamic environment for warehouse auto-mation are implemented Prof. Dzmitry Tsetserukou (SC) • communication with Sberbank, Decathlon, Ozon, Okey

Advance Ion-exchange • 5-stack cell prototype is developed Membranes for Redox-flow • 1 RU patent application batteries • communication with Solar Systems, Teemp, Russian Prof. Keith Stevenson (CEST) Railways, Fumatech. 108

ANNUAL REPORT // SKOLTECH In 2018 the following new seven projects were selected to the Program 2018-2019:

Development of potassium-ion • new K-ion electrolyte and cathode materials are developed batteries • applied for Skolkovo residency Prof. Artem Abakumov (CEST) • first commercial contract with LG Chem • communication with LG, Liotech, Saturn, InEnergy

Pultrusion structural profiles • thermoplastic reinforced material is developed based on fibre reinforced • received Skolkovo residency thermoplastic pre-impregnated • startup T-Tech created materials • communication with Invest-Trade Prof. Iskander Akhatov (CDMM)

Metagenomic approach for oil • 147 samples from Rosneft well are obtained and analyzed and gas industry Prof. Mikhail • communication with Rosneft, Sibur, Lukoil Gelfand (CLS)

Platform for Detection • the design of the microfluidic chip is developed, chip assembled of Human Health Markers • passed preliminary expertise for Skolkovo residency at Point-of-Care (POC): • communication with N.N. Blokhin Cancer Research Center An Interface of the Physical and Life Sciences Prof. Dmitry Gorin (CPQM)

Strong coaxial filament • prototype of coaxial extrusion head is developed for 3D printing • first coaxial filament samples are 3D printed Prof. Albert Nasibulin (CPQM) • received Skolkovo residency • startup Novaprint 3D created

G(ame)-psycho • hardware platform with external sensors is developed Prof. Andrey Somov (CDISE) • passed preliminary expertise for Skolkovo residency • received RFBR funding (4 mln RUB) for 1 year • communication with Nike and MTS

Syntelly – Computer aided • deep neural network-based system for acute toxicity profiling organic synthesis of organic compounds is developed Prof. Maxim Fedorov (CDISE) • received Skolkovo residency • startup Syntelly created • communication with Elsevier, ImG, Orgsyn, Migo-Group

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/02 ACADEMIC & TECHNOLOGY EXCELLENCE The patent activity in 2018 showed a signifi- • Superplastic Aluminium Alloy (Variants), cant increase. 38 applications were submitted Use Thereof And Product Made Therefrom to the national and international patent offic- (PCT/RU2015/000731) Mikhaylovskaya es, among international applications: A., Kotov A., Portnoy V., Kishchik A., Kishchik M. (STRIP) • Virtual Reality System Based on Smartphone with Slanted Mirror (PCT/ • A nanoelectrode for detecting cu(ii) RU2018/000452) V.Lempitskiy (CDISE) ions and a method of producing and using thereof (PCT/RU2015/000958) • Calibration method and system (PCT/ Erofeev A., Gorelkin P., Majouga A., RU2015/000378) Kirsanov D., Panchuk V., Usmanov A., Yaminsky I., Korchev Y. Khaydukova M., Legin A. (STRIP) (STRIP)

Patent applications 2016 – 2018

CDISE 3 4 13

CLS 2 2

CNBR 2

CDMM 1 1

SC 2

CEST 1 5 6

CHR 3 4

CPQM 2 1 4

STRIP 1 1 3

GCF 2

2016 2017 2018

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ANNUAL REPORT // SKOLTECH 111

/02 ACADEMIC & TECHNOLOGY EXCELLENCE 112

ANNUAL REPORT // SKOLTECH Value Generation /03 Industry Funded Research

In comparison with the previous year, Ireland, enterprise «Elita», Institute for 2018 showed a double increase in the Animal Husbandry (VIZh) (led by Prof.Philipp annual amount of funding under R&D Khaitovich, CNBR). In parallel, negotiations contracts. The amount of work performed regarding the further expansion of by the Institute totaled to 857 mln Rub. genotyping with several major players in The portfolio of CREIs contracts included the industry are ongoing. 108 R&D projects covering a variety of • A pilot project «Digital ship” with the Sredne- specializations; among the contractors are Nevskiy Shipyard, involving the creation Russian and international companies – Total of a platform for monitoring the vessel E&P Recherche Developpement, Airbus SAS, life cycle and processes associated with Huawei, Gazpromneft, Lukoil Engineering, its operation was implemented by a joint Phillips Innovation Labs, National Technology team of IoT Center (Prof. Dmitry Lakontsev, Initiative, Russian Venture Company and Serafim Novichkov) and CPQM (Prof. Arkady others. New contracts were signed for 1,5 Shipulin) billion Rub, ~1,4 bln Rub of which are • Skoltech was awarded the title “The Best secured for period of 2019 – 2022. Scientific Partner” by Gazpromneft. Research collaboration contracts with Among completed projects are: Gazpromneft and other oil companies were expanded focusing on applied • Techniques developed by Applied research results and development of Information Theory group (CDISE) will be new technologies for exploration and implemented in future wireless networks as production of hydrocarbons, including well as fiber optics lines and cloud storage advanced modeling, artificial intelligence systems through cooperation with industrial and materials design technologies partners, including Huawei. Among the highlights: creation of New • Advances in approaches to data analysis Superhard Materials for drill bit cutters, achieved by Scientific Computing, Advanced Multiphase Systems Modeling Advanced Data Analytics and Deep Technologies, AI-based Digital Reservoir Learning groups (CDISE) are implemented Models using Machine Learning methods, by various companies including Huawei, Advanced Digital Rock technologies Yandex, Sberbank, and LG. • Projects with Philips on detection of • The project on perforated honeycomb structure pathologies in radiological medical records for space devices construction successfully to improve the methods of agnostic training completed with Roskosmos and NPO PM in the analysis of medical images (led by MKB. As a result, batches of 6-sided and Prof. Dmitry Dylov, CDISE). flexible honeycomb structures of aluminum • establishment of the Center of Excellence foil were created (led by Gennady “Wireless Communications and Internet Rudensky and Prof. Ighor Uzhinsky, of Things” in consortium with more than Laboratory for Cyber-Physical Systems 50 industrial and academic partners (CDMM). (MIET, HSE, SUAI, SPBSTU, Huawei, • Project on cattle genotyping in Tatarstan in Sberbank, Rosseti, Philips, Cherkisovo, partnership with Sustainable Food Systems Nordgold etc).

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ANNUAL REPORT // SKOLTECH Portfolio of R&D contracts funding, mln rub

178.5 CDISE 783.9

CLS 87.0 26.6

CNBR 21.8

10.0 CDMM 158.4

22.0 SC 14.4

132.2 CHR 301.7

13.5 CEST 45.5

141.5 CPQM 74.5

R&D contracts portfolio as of 1 Jan, 2018 R&D contracts portfolio as of March, 2019

The chart presents R&D contract portfolio, e.g. total amount of funds secured for the upcoming period.

ALEXEY PONOMAREV, Vice President for Industrial Cooperation: “This year, we have achieved tangible results in various applied research projects that run a gamut, ranging from a manufacturing technology for spacecraft structures to a livestock genetic monitoring system. This is a good basis for moving on to more formi- dable challenges.” 115

/03 VALUE GENERATION 116

ANNUAL REPORT // SKOLTECH // TRANSLATING SCIENCE INTO TECHNOLOGY ALUMINUM FOIL FOR SPACE

The collaborative endeavor of Skoltech high-precision assembly and enhanced stress- and Academician M.F. Reshetnev strain performances. Information Satellite Systems (ISS- High-accuracy sheet positioning in Reshetnev) has materialized in a new the honeycomb assembly was the project’s key composite technology for manufacturing engineering challenge; the designers addressed the aluminum foil honeycomb core. this using machine vision technologies and Honeycomb structures are widely used in high-speed video processing algorithms the aerospace, shipbuilding, automotive, developed at Skoltech. and consumer sectors. The aluminum honeycomb core is The new product was developed under an indispensable element in high-specific- contract with Roscosmos State Corporation. strength structures that should withstand Used primarily in spacecraft structures, large loads while having the lowest possible the aluminum foil honeycomb core is a weight. These are in high demand in a variety high-strength lightweight composite material of sectors, particularly in the space industry with 23 micron thick foil and a 2.5 mm where the costs increase manifold with every long cell face. extra kilogram. Skoltech engineers developed unique In October 2018, an aluminum-honeycomb equipment leveraging on the capabilities of core production line was launched at NPO laser and machine vision technology and PM‒Small Design Bureau, which makes part cutting-edge automation solutions and were of ISS-Reshetnev. This unique and complex the first to propose and implement a novel facility, unrivaled in Russia, was built from adhesive strip positioning method ensuring scratch and tested within the space of a year.

/03 VALUE GENERATION Skoltech. Gateway to the World New Enterprises & Technology Licensing At the end of December 2018, Skoltech seed funding from Draper Associates and had established 43 start-ups from 2013 is selling its geospatial data to architects, by faculty, researchers, students and alumni; municipalities and others. Nataliya Glazkova, of these companies, 26 companies have founder of Cardiolog, was given a special established Skolkovo residency. Several start- award of appreciation by the President ups received international recognition. of Armenia during a start-up competition The total income generated from Skoltech challenge. start-ups in 2018 reached more than 100 mln Rub. Of this figure, start-up Rustor generated 15 mln Rub, Cyber Academy – Start-up activity at-a-glance: 30 mln Rub and Inspector Cloud – more than 40 mln Rub. • ProctorEdu LLC (Adeny Adebayo (Class of 2016) and Inspector Cloud (Pavel At one of the Russia’s most prestigious Boyko) were selected by international start-up events, known as ‘Accelerator of startup accelerator 500Startups and Sberbank and 500 Startups’, Skoltech start- Sberbank for a joint accelerator at the ups performed very well and with 10%, had end of an initial review stage. Each of the the largest share of entries as finalists at selected teams will receive investments this country-wide competition whereby the in the form of a convertible loan of up selection process began during Q3, 2018. to 10 million rubles, and the seven best Skoltech companies chosen as finalists were: companies will go to Silicon Valley for Shipitto, Zenome, and ProctorEdu. acceleration during 2019. • SENSE2BEAT was selected as a During the course of the year, individual distinguished start-up at the Samsung Skoltech entrepreneurs were also recognized Connection Day in Moscow; and, it its with distinction outside Russia. Hripsime founder was rated among 10 young Matevosyan, a former Skoltech PhD student, innovators from around the world at the Wish was named among Forbes USA “30 under Summit held in Qatar. Also awarded the 3rd 30: manufacturing & industry”. Matevosyan place winner from over 125 entrees at Sevan co-founded Swiftera, a high-altitude imaging Start-up Summit during July in Armenia and company that uses a floating camera to go selected for the IDTechEx Launchpad, with above what drones can reach but below the the opportunity to showcase prototypes and level of satellites. Her company has raised demonstrations of their new products”

118

ANNUAL REPORT // SKOLTECH Enterprises by founders Enterprises (SK clusters)

Engineering Biomed

Students, Academic alumni staff 49% 51% Energy

IT

Enterprises established by Skoltech faculty, researchers, students & alumni (cumulative from 2013)

26

19 12 17 9 1 4 5 6 2013 2014 2015 2016 2017 2018

Non-Sk residents Sk residents

Several Skolkovo startups are collaborating the equipment where possible. Among the with Skoltech in terms of using the Institute’s partners are – “Геро” (Gero), “Реал Таргет” resources – space for rent, help of legal\ (Real Target), “ЛП ТЕХНОЛОГИИ” (LP accounting operations, IP support (owned Technologies), “Клайбер бионикс” (Clyber by Skoltech or jointly) in order to license it Bionics), the majority of companies are to a startup further on, startup’s access to collaborated within the Cobrain Center.

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/03 VALUE GENERATION The highlight of the year was Skoltech’s availability of CRISPR biological science. entering into a joint invention administration In particular, the CRISPR C2c2 system agreement with the Broad Institute (MIT), provides an important addition to the suite Harvard and Rutgers University to make of molecular biology tools, allowing for jointly-developed intellectual property related targeting of RNA, which helps with crucial to CRISPR systems. The IP, also co-owned steps in protein synthesis, for example. by Harvard and the MIT, relates to CRISPR “This technology represents a transformative systems referred to as C2c1 (Cas12b) and opportunity to improve human health,” C2c2 (Cas13). Beginning in 2015, a team said Issi Rozen, chief business officer of collaborators announced the discovery of the Broad Institute. “We are proud to and characterization of these CRISPR partner with Skoltech and many other systems. This international cooperative effort collaborating institutions to share these has strengthened the understanding and tools openly.”

2 licensing agreements were signed (СDISE): designed to perform functional testing of the ERA-GLONASS emergency call devices and • Non-Exclusive License Agreement for it is a GSM base station emulator, a GSM Software MARIE++ Interactions modelling of core emulator (MSC / HLR), a voice SIP electromagnetic waves with biological tissues server, an SMS message processing server in next-generation MRI systems. and emulator of the server for receiving Authors: A.Polimeridis, M.Litsarev, G.Guriev, and processing of the Minimum Data Set I.Georgakis (MND) from the UEEP – PSAP (Public-Safety Licensed to the international company: Qbio, Answering Point). Inc., USA Authors: D.Lakontsev, S.Novichkov, A.Ivanov • Exclusive License Agreement for Licensed to Russian company: NOVYE Software ERA-GLONASS. The program is INZHENERNYE TEKHNOLOGII, LLC

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ANNUAL REPORT // SKOLTECH Natalia Glazkova – CEO of the Sense2beat project, winner of the summer competition “Sevan Startup Summit 2018” received the special prize of the President of Armenia Armen Sarkissian

ISSI ROZEN, chief business officer of the Broad Institute: “This technology represents a transformative opportunity to improve human health. We are proud to partner with Skoltech and many other collaborating institutions to share these tools openly.” 121

/03 VALUE GENERATION Professional Training

The activities on professional training • Introduction to Additive Manufacturing programs started in 2018 with defining key Technologies (CDMM), areas of product portfolio. About 60 courses • Intelligent Systems for Electrical Heating covering artificial intelligence, data science, Energy Consumption Management (CEST) hydrocarbon recovery, additive technologies, for representatives of energy industry composite materials, systems engineering, companies. PLM were identified for promotion on professional education market. The special landing page on available courses was launched on Skoltech web page. The first The courses were delivered to high-tech B2C marketing campaign resulted in enrolling companies, institutes of development. Among attendees for five courses. the clients – Gazpromneft, Russian Railways, Bitfury, Novartis, Boeing Russia, Titan In 2018 Skoltech also established Avangard, VNIINeft (Zarubezhneft), Sberbank, collaboration with the Russian Federation Rostelekom, Libelium, University 2035, Ministry of Health. Within the framework Moscow Business School. of collaboration Skoltech (Supporting Skoltech Center – Center for Open Learning) Select examples of courses and seminars delivered: developed 80 modules for obligatory additional medical education for clinical • Machine learning (CDISE) for Sberbank, doctors and pharmacists. Although medical • Artificial Intelligence (CDISE) for Central competencies aren’t within its core Bank of the Russian Federation, expertise, Skoltech introduced modern • Technology block chain (CDISE) for medical data analyses into routing health Corporate University of Russian Railways, care practices. Programs were created for • Sensors and Embedded systems for the Ministry portal for continuous medical Internet of Things (CDISE) for Gazpromneft, education in partnership with Russian • Fundamental scientific principles of Federal Research Center for Medical genome editing (CLS) for Novartis Pharma Genetics and N.N. Blokhin National Medical & Pharm-Sintez, Research Center of Oncology.

ALEXEY LYAKIN, Vice President and Director of Sberbank’s Treasury: “The ability to embed technology in the bank management and business processes is the key to staying fully operational and competitive over the five-year horizon and beyond. There is an apparent need to implement blockchain technology in transactions, biometrics in client identification and machine learning methods; this includes neural networks and surrogate modeling, to facilitate customer relations and optimize internal decision-making with regard to the impact of the rapidly changing market and macro- economic environment on the bank’s profits and risks. Decision-making already benefits 122 from an impact assessment process based on machine learning models.”

ANNUAL REPORT // SKOLTECH //SKOLTECH & SBERBANK SKOLTECH COURSE FOR SBERBANK CORPORATE UNIVERSITY

Skoltech’s course, tailored for Sberbank, The lectures focus on various covers data analysis and machine learning. mathematics-related topics. The curriculum The course is 40 academic hours and covers 5 also includes a lecture on recommender topics with four lectures and four workshops. systems. The average group size is 20 participants.

/03 VALUE GENERATION Skoltech. Gateway to the World Advisory Services

Development of analytical • White Book “Internet of Things: Promising Markets and materials and policy briefs Technologies” on science, technology & • Materials on strategy for development of radio electronic and innovation electronic industries in Russia and telecom market (including perspectives for photonics applications and 5G network deployment) • Technological review on Multi-beam electron lithography

Analytical support to • Participation in road mapping for AeroNet, SpaceNet, development of strategies, TechNet (NTI working groups) programs, standards in • Participation in R&D initiatives in energy storage (NTI science & technology e-mobility project) development • Participation in work for improving the Concept and Plan for the International Scientific-Technological Cooperation developed by the Ministry of Science and Higher Education • Proposals on the Digital Economy Program (Federal project “Regulatory Framework” and “Digital Technologies”)

Advising and • 1st BRICS Working Group on Photonics (Ministry of Science analytical research for and Higher Education) defining priority areas for governmental bodies, collaboration within Joint Calls 2019, institutes for development • Addressing queries from the governmental bodies, including suggestions on mechanisms of open access to platforms to be used by research organizations and high-tech companies; amendments to the Concept of development of standards in the RF; proposals to the Ministry of Economic Development on creation and functioning of technology transfer centers; proposals on technical requirements to the Roadmap for Development of cross-sectoral key enabling digital technologies • Report on prospects for usage of domestic telecom equipment (presented at a working meeting chaired by the Deputy Prime Minister M.A. Akimov) • Analytical support to the Skolkovo Foundation (potential markets for professional development training, current state of online learning in the area of professional education, potential markets for advisory services)

Advisory services • scientific and technological expertise for Lukoil, for high tech companies Zarubezhneft, SuperOks, Agrogenetika, “Systems MFM” • consulting services to VneshEkonomBank (VEB) on investing to space telecommunications infrastructure • consulting to URALCHEM – analytics on Soil Phosphorus- solubilizing microorganisms • Technology audit of Mapper LLC, Netherlands (Rusnano portfolio company) was performed for Rusnano. Results of the report led to global strategic decisions and considerable budget saving. • Advisory to Vnesheconombank (VEB) on Energy and Space projects 124

ANNUAL REPORT // SKOLTECH Skoltech is presented in a range of Federation President, governmental boards, advisory groups and • Russian Federation Board on prioritization R&D councils of high-tech companies: of research and technological directions in the . area of oil and gas industry, • Council on Science and Education under • Board of the Digital Economy Program, the President of the Russian Federation, • Working group “Standardization” of the • Economics Council under the President of Digital Economy Program, the Russian Federation, • Working Group on Cyber-physical systems • Commission on Technological Development in Rosstandart. of Russia’s Economy under the Russian

Meeting of the 1st BRICS Working Group on Photonics (March, 2018)

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ANNUAL REPORT // SKOLTECH Campus

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ANNUAL REPORT // SKOLTECH Opening of Skoltech’s new campus took place on September 1, 2018 129

/04 CAMPUS Campus

The new campus was partially delivered lectures on a regular basis. CDMM academic in October 2018 with enough space to begin personnel were set up in their new space, and teaching activities for about 400 students, preparatory works required to relocate CDMM office space for roughly 120 staff and labs was commenced and will be complete by seminar/conference space for 500+ guests the end of Q1 2019. and a seating capacity of 250. The remainder The Advanced Imaging and Masterskaya of teaching and learning spaces, cohort/ facilities have also commenced relocation project-based space, seminar and conference activities. The Masterskaya facilities will be rooms, and office space will be delivered to stood up by the end of February 2019, and Skoltech during Q1 2019. the Advanced Imaging facilities by the end of Building engineering systems are installed March 2019. and operating manually while automation The remainder of the administrative staff systems testing and commissioning is being and some faculty will be relocated to the new completed. In accordance with schedules building by the end of Q1 2019. As Institute confirmed by the Foundation/ODPS, building facilities are relocated to the new campus, automation will be completed and delivered to we continue to consolidate faculty and staff Skoltech during Q1 2019. into TPOC-3, and free up space in TPOC-4 Logistics and chemical storage facilities in accordance with both approved relocation were under construction and planned for schedules and the Institute budget. delivery in Q1 2019. For the time being, The lab/research facilities design and Skoltech continues to use TPOC-3 as the construction program continues to move primary delivery and distribution point for all according to schedule and will be completed incoming materials required for the Institute by the end of 2021. operations. Skoltech’s new campus is located just Dining and kitchen facilities also remained east of the Technopark, and across from under construction with an expected delivery the Matreshka and Hypercube buildings, of end of Q1 2019, and a food service adjacent to future playing fields and a operator has been selected. Over the course sports complex, which is currently under of 2019, as critical mass is achieved in the development by the Foundation. More than building, other amenities such as cafes, a just a technology and research park, the bookstore, banking machines and a restaurant Skolkovo Innovation Center complete work/ will be opened. study/live environment, offering world-class Relocation of the Institute was commenced facilities for living, research, business and in October of 2018. As of end of 2018, a socializing, with rich and comfortable urban total of 120 staff members were relocated, environment (map with indication of main and just under 400 students were attending locations).

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ANNUAL REPORT // SKOLTECH Prime Minister of the Russian Federation Dmitry Medvedev visited Skoltech’s new campus 131

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ANNUAL REPORT // SKOLTECH Operational Management /05 The Operational Management Block • reengineering of business processes provides the Institute with a variety of completed, the new ERP (Microsoft Dymanics services, including financial planning and AX 2012 R3) launched, controlling, accounting, human resources • internal controls, addressing risks and management, IT and legal support, precisely described in Risk Control Matrices, procurement, internal control, safety. are being embedded into business processes Among major activities of the year: during implementation of the ERP and further integration with IT infrastructure, • implementation of International Financial • online reporting and automated budget Reporting Standards (IFRS), transfer system (EPS Cognos) implemented, • completed audit made by the Skolkovo • Directum (EDMS) launched, Foundation (KPMG) for target use of the • Student Information System (SIS) project Foundation Grant; audit according to launched, IFRS and Russian accounting standards • Service Level Agreement launched in (unqualified (positive) opinion received), a number of services, • legal support on the Institute’s activities, • project for Information Security support on establishing Skoltech enterprises, Management launched to mitigate • procurement routine implemented to cyber security risks and ensure legal ensure value for money, compliance with the Federal Law • archive solution (digital and hard-copy) “On Personal Data”, implemented, • approach for warehousing developed • migration to a new travel provider completed, (to be implemented in 2019).

TATYANA ZAKHAROVA, Vice President for Finance & Operations: “We are constantly working on improving operational activities and are aimed at opti- mization and automatization of business processes at all levels. On-line reporting and automated budget transfer system has been successfully implemented, the new ERP 134 system has been developed for further implementation.”

ANNUAL REPORT // SKOLTECH GLOSSARY

GRANT AGREEMENT СTB SC Agreement between the Institute Center for Translational Space Center and Non-commercial organization Biomedicine “Foundation for Development SKOLTECH, INSTITUTE of the Center for Elaboration CPQM Autonomous Non-Profit and Commercialization Center for Photonics and Organization for Higher of New Technologies” (Skolkovo Quantum Materials Education “Skolkovo Institute Foundation) of Science and Technology” CREI (CENTER) СAS Institute’s structural unit STRATEGIC ACTION PLAN Center for Advanced Studies implementing a long-term (SAP) (at least three years) Institutional Plan for CDIBB development program, aimed Development which sets Center for Data-Intensive at integration of research vision, strategic goals Biomedicine & Biotechnology and education activities, and initiatives, KPIs, tasks value generation (Centers and actions, responsibilities, СDISE for Research, Education budget. The SAP is developed Center for Computational and Innovation (CREIs), for a three years’ cycle, Data-Intensive Science Center for Advanced Studies) annually updated and and Engineering approved by the Board GCF of Trustees. The SAP serves CDMM Genomics Core Facility a basis for the Grant Center for Design, Agreement, reporting to Manufacturing and Materials SKOLKOVO FOUNDATION the stakeholders Non-Commercial Organization CEE “Foundation for Development STRATEGIC KPI Сenter for Electorchemical of the Center for Elaboration Institutional key performance Energy Storage and Commercialization of New indicator, established in the Technologies” Subprogram and / or Grant CEI Agreement Center for Entrepreneurship KPI and Innovation key performance indicator of SUBPROGRAM the Institute’s development Subprogram “Establishment CES and Development of the Center for Energy Systems LEARNING COMMONS Skolkovo Innovation Center” special Campus spaces that in the frames of the State CEST integrate computing and Program of the Russian Center for Energy Science library services, makerspaces, Federation “Economic and Technology equipment, tools, shared for Development and Innovative tutoring, reading, team-work, Economy” CHR aimed at stimulating active Center for Hydrocarbon Recovery learning (available 24/7) TARGET DOMAIN strategic focus area of CLS RFBR the Institute’s education, Center for Life Sciences Russian Foundation for Basic scientific, research and Research development and (or) CNBR innovation activities. Center for Neurobiology RSF Approved by the Board and Brain Restoration Russian Science Foundation of Trustees within the SAP.

135 SKOLKOVO INSTITUTE OF SCIENCE AND TECHNOLOGY (Skoltech) 143026, Moscow, Bolshoy boulevard 30, build. 1. Tel. +7 (495) 280 14 81 www.skoltech.ru

The information in this report was correct at the time of printing (March 2019). The University reserves the right to alter or amend the material contained in this report.