Charles University Faculty of

in Hradec Králové WWW.LFHK.CUNI.CZ

In the World of Modern Medicine Based upon Special Section published in Scientific American Czech Edition 700 YEARS CHARLES IV FOUNDER OF THE CHARLES UNIVERSITY http://charles700.cuni.cz/ Charles University Faculty of Medicine in Hradec Králové

Charles University Faculty of Medicine in Hradec Králové, www.lfhk.cuni.cz 1 Table of Contents 30 Department of Anesthesiology and 4 Faculty of Medicine in Hradec Králové Intensive Care Medicine 6 Department of Anatomy 31 Department of Dermatology and Venereology 7 Department of Medical Biology and Genetics 32 Department of Infectious Diseases 8 Department of Physiology 33 Department of 26 9 Department of Histology and 34 Department of Rehabilitation Embryology 35 Department of Ophthalmology 10 Department of Hygiene and 36 Department of Otorhinolaryngology 42 Department of and Preventive Medicine and Head and Neck Surgery Radiotherapy 11 Department of Languages 37 The Fingerland Department of 43 Department of Dentistry 12 Department of Medical Biophysics Pathology 44 Department of Clinical Microbiology 13 Department of Medical Biochemistry 38 Department of Pediatrics 45 Department of Clinical 14 Department of Social Medicine 39 Department of Obstetrics and Biochemistry and Diagnostics Gynecology 15 Department of Pharmacology 46 Department of Clinical Immunology 40 Department of Psychiatry and Allergology 16 Department of Pathological Physiology 4 41 Department of Radiology 47 Department of Forensic Medicine 48 Radioisotope Laboratories and 17 Academic Department of Internal Vivarium Medicine 49 Department of Physical Education 18 1st Department of Internal 50 Department of Information Medicine – Cardioangiology Technology 19 2nd Department of Internal 51 Medical Library Medicine – Gastroenterology 20 3rd Department of Internal Medicine – Metabolic Care and Gerontology 21 4th Department of Internal Medicine – Hematology 22 Department of Occupational Medicine 23 Department of Pulmonology 24 Academic Department of Surgery 25 Department of Surgery 26 Department of Cardiosurgery 27 Department of Neurosurgery 28 Department of

6 29 Department of Urology 42 22

2 Based upon Special Section published in Scientific American Czech Edition Charles University Faculty of Medicine in Hradec Králové, www.lfhk.cuni.cz 3 Charles University Faculty of Medicine in Hradec Králové www.lfhk.cuni.cz

In the world of modern medicine International partnership and student mobility

The Faculty of Medicine in Hradec Králové is the oldest school providing uni- The Erasmus student exchange program offers the possibility to spend one or two terms at versity education in Eastern Bohemia. It came into existence on October 13, European universities. Similar programs are also offered by the IFMSA organization. 1945, first of the medical faculties founded after WW II, and became a part of Our faculty has a long-standing and above-standard partnership with the prestigious MAYO the Charles University, the oldest university in central Europe and north of the Clinic in Rochester, USA. This unique long-term cooperation surpasses other faculties of me- Alps. It offers undergraduate and postgraduate education and organizes courses dicine in the Czech Republic and enables us to send approximately 10 undergraduate or post- Undergraduate bachelor´s focused on the continuing education of doctors. graduate students on a three-month study stay in Rochester. The stays are of a scientific nature, degree study program Excellent preparation for practice usually linked to the sphere of interest and a perspective field of the future professional interest Nursing of our students. Such a partnership often brings publication outcomes. All those who have par- Today´s doctors can perform real miracles compared with what they could do just sev- ticipated in this stay at the MAYO Clinic unanimously agree that it is an extraordinarily stimu- “The Faculty can teach us only what we eral years ago. Contemporary medical science is based on a wide interdisciplinary ap- lating activity, which in some cases continued in the form of a fellowship at other prestigious Master’s degree want to learn.” proach and helps make what was once impossible now possible. However, employing such clinics in the USA. study programs Prof. Miroslav Červinka, M.D., Ph.D. new approaches requires great skill and mastery to connect and link in an innovative way Another often used option of cooperation with foreign institutions is the agreements be- Dean of the Faculty of Medicine, Czech and English programs: and to become familiar with the latest devices and equipment. This is why we put stress tween individual faculties. Moreover, there are hundreds of other agreements held between our Charles University in Hradec Králové Dentistry on modern teaching methods using IT technology. The students then strengthen their university and other such institutions which open up avenues of international cooperation for theoretical knowledge by using them in practice. our students and staff. Miroslav Červinka graduated in 1973 from the General Medicine Faculty of Natural Sciences, Charles University in Prague Rich cultural life in the field of animal physiology. In 1984, he graduated from the Faculty of Medicine of Charles University in Doctoral study programs We organize annually a spring concert Hradec Králové and in 1980 he finished his Ph.D. in the The faculty offers 42 doctoral study where well-known artists of the musical field of animal physiology at the Faculty of Medicine in world like P. Šporcl, J. Svěcený, D. Bárta, Hradec Králové. In 1990, he achieved the academic title programs, out of which half are in Czech of associate professor in the field of general biology and and half in English. O. Havelka and the Melody Makers, in 2000 he was appointed professor in the field of histo- J. Suchý and J. Molavcová perform. We logy and embryology. His interests are time-lapse recor- really value our autumn concert where the ding and image analysis, regulation of cell proliferation Study specializations for students of our faculty perform. Our and cell death, apoptosis, assessing toxicity on cells habilitation and professorship medical faculty also contributes to the grown in vitro and mechanisms of chemoresistance in There are 21 accredited specializations selected tumors. He is the main author or co-author of cultural life of the town and organizes var- 400 publications. for habilitation and 18 for professorship. The spirit of cooperation ious exhibitions. Since 1990, we have organized many such exhibitions in the faculty building. Paintings, draw- Possibilities for student We closely cooperate with the University Hospital Hradec Králové, where specialized ings, graphics, art and documentary photographs, textile art or cartoons are exhibited in the Na accommodation classes for students are run by head doctors of individual clinics and by other experts from Hradě Gallery, in the building which also hosts the medical library. Various authors not only the University Hospital Hradec Králové. from East Bohemia but from other regions present their works here. We could see works from Pharmaceuticals are an inseparable part of a doctor’s work. This is why we closely co- artists like O. Zoubek, V. Komárek, L. Jandová, B. Votavová, B. Borovský, J. Anderle, V. Renčín. operate with the Charles University Faculty of Pharmacy in Hradec Králové. There is a The auditorium has also been used for festive academic meetings and various conferences common Department of Physical Education shared by both faculties. and other social events. One such popular event is the Graduates Night, where international students present their cultural traditions. The Faculty of Medicine, together with the Associa- tion of Students of Medicine, organize an annual representative ball. We also organize a faculty Improvements in Mardi Gras carnival. technology continue Contacts: Sports achievements Jan Palach dormitories Charles University Modern technology of the leading world- The Department of Physical Education organiz- Faculty of Medicine renowned companies can be found in all work- es regular and casual sport competitions. One such in Hradec Králové places throughout the faculty. The equipment competition is a football match between academic is continuously updated and modernized. staff and students of the faculty, an event which has Šimkova 870 many followers. The Department of Pathological 500 38 Hradec Králové Inexhaustible source of information Physiology regularly organizes within the rector´s Tel.: +420 495 816 111 day a 20K-walk-run-cycling event to a specified The medical library offers an enormous collection of the latest publications as well as destination in Vysoké Chvojno. Other sport compe- E-mail: [email protected] classical works. In addition, users have access to on-line editions of leading scientific jour- titions like volleyball or golf tournaments are also or- Na Kotli dormitories nals. ganized during this particular day.

4 Based upon Special Section published in Scientific American Czech Edition Charles University Faculty of Medicine in Hradec Králové, www.lfhk.cuni.cz 5 Faculty of Medicine in Hradec Králové Charles University Department of Anatomy Department of Medical Biology and Genetics A basic field of medicine The biggest portion of teaching is concentrated in both terms of the first study year From cells to tissues and organisms in the master´s degree program. Systematic and topographic anatomy are taught to Medical biology is a traditional part of the study programs of General Medicine the students in the Czech program as well as those in the English program. The den- and Dentistry. The classes cover two semesters. The contents of the first semester tistry students have applied anatomy of the head and neck in their third study year and is cell biology; we try to introduce the cell as the basic element of life. At the same the course is taught in cooperation with the Department of Dentistry. We offer an op- time, we emphasize the dynamic aspect of the cell’s life and the interactions of in- tional subject called Clinical Anatomy and Chosen Chapters from Topographic Anato- dividual cell structures and compartments involved in basic cell functions. The stu- my to the second year students of dents have the opportunity to become acquainted with microscopic techniques general medicine. These subjects which enable a long-term observation of living cells, such as phase-contrast “Our brain is what we think are offered in both the Czech and microscopy, time-lapse video microscopy, and fluorescent microscopy using color “The wisest and noblest teacher is nature we use for thinking.” English language programs. The fluorescent proteins. Another important teaching topic is the use of cells grown in itself.” (Leonardo da Vinci) Assoc. Prof. Dáša Slížová, M.D., Ph.D. seminars are organized in coopera- vitro as a biological model for research as well as for testing cytotoxicity. The se- Prof. Emil Rudolf, Pharm.D., Ph.D. Head of the Department of Anatomy tion with teachers from clinical cond semester is devoted to the basics of molecular biology, medical genetics, and Head of the Department of Medical Biology and fields, mostly from surgery, radiolo- the genetics of tumors. The students isolate DNA, carry out gel electrophoresis of Genetics Museum of Anatomy gy, otorhinolaryngology, orthope- nucleic acids, and prepare karyotypes during the practical seminars. Other stu- Fighting tumors To found and build up a museum of anatomy is often a dics and physiotherapy. Anatomy dent activities are focused on practicing the basics of Mendelian genetics, inclu- This part of the research, which consists of several task for many a long year or even decade. According to lessons are also included in the 1st ding analysis of pedigrees, and on using molecular methods for diagnosing heredi- sub-areas, is at present the most prominent for our sources, the basis for the Museum of Anatomy was the year of the bachelor’s degree study tary diseases and for identifying people. In addition, during the course, students collection of bones provided by the courtesy of the first department. First of all, research focuses on mecha­ Lesson in the autopsy room. head of the department, Libuše Fučíková, M.D. This program in General Nursing. have to prepare their own presentation concerning the latest discoveries in the field nisms of effects of substances that can possibly be osteological collection was significantly enriched by a of biomedicine. The follow-up of the mandatory subject Medical Biology is the chemopreventive. We consider both synthetic and large collection of bony material from the XIII. – XVIII. elective subject Clinical Applications of Molecular Biology. natural substances. The activities of these substances centuries which was obtained from the former Ossuary are observed on chosen models of tumors, namely on of the Monastery in Broumov. Although many new mod- To help the students colorectal carcinomas, ovarian carcinomas and on ern methods have been used when teaching anatomy Research microcinematography for observing cell dy- melanomas. With regard to the practical outcome of today, the Museum of Anatomy and its exposition still Through electronic teaching supports the or e-learning courses on more difficult top- namics. In this respect, our department has our research, we focus on the possibilities of inducing various types of cell death, autophagy and senescence. play an irreplaceable role in preparing future doctors. Department of Anatomy offers students of ics, for example neuro-anatomy and topo­ Since the 1960s, the basic research focus of always been a pioneer within the whole of Eu- These experiments have currently been further deve- all study fields a complete groundwork for graphic anatomy. Discussions and feedback the department has been the same: the study rope. Currently, a dynamic time-lapse cyto- loped in the direction of epigenetic regulation by ana- lectures and practical seminars, collections of are ensured by an e-learning forum and a Fa- of the dynamics of basic cell processes. We metry is still our basic experimental approach. lysing chosen small regulating molecules of RNA. photographs from the Museum of Anatomy cebook profile of the department. have always employed phase contrast The knowledge from dynamic cytology is microscopy in connection with time-lapse used for the study of biological characteristics of chosen groups of substances, namely drugs Research activities of the department and food supplements. The focus of this area of toxicology in vitro was both linked with 1. Scanning electron microscope of biologi- 2. Experimental intoxication of the central the research of biological mechanisms of the cal samples: nervous system, inhibitors of cholinester- studied entities and also with another much – Cardiac valves and vascular grafts – ase and observations concerning the ef- wider area of study – the effort to introduce Anthropometric points – a display from the morphological examination of aortic fect of prophylactic administering of an- so-called alternatives to experiments on Co-localization of caspase 3 and Museum of Anatomy valves and pulmonary valves in a tissue tidotes by histochemical methods. laboratory animals. Our department has cytokeratin 18 in dying cells (200x) Contact: bank, explanted pathologic valves, and 3. Research of the permanent cartilage de- been at the forefront of this field of research Contact: valves from experiments on animals. velopment and the importance of calcifi- in the Czech Republic, which is reflected in Charles University Charles University – Teeth and dental implants (in coopera- cation of rib cartilages in men. our close cooperation with similar European Faculty of Medicine tion with the Department of Dentistry). 4. Research of blood supply and vein drain- Microtubules and mitochondria in a tumor cell centers for alternative methods such as Faculty of Medicine in Hradec Králové – Materials implanted into the bones of age of liver. (400x) FRAME, ZEBET, ECVAM. in Hradec Králové experimental animals (in co- Department of Anatomy Department of Medical operation with the Depart- Biology and Genetics Šimkova 870 ment of Orthopedic Surgery). One of the first in the Czech Republic – Examination of biodegradable Šimkova 870 500 38 Hradec Králové esophageal stents, artificial In 1994 the department became one of the and Great Britain. Our department also suc- 500 38 Hradec Králové Tel.: +420 495 816 230 eye lenses, and similar items. first in the Czech Republic to participate in ceeded as one of the few institutions in the Tel.: +420 495 816 494 the prestigious Joint European project. The Czech Republic in gaining accreditation E-mail: [email protected] E-mail: [email protected] project was coordinated by Professor from the Czech Accrediting Institute for the www.lfhk.cuni.cz/anatomy Images from the scanning electron microscope enable detailed observation Červinka. The other participants were top Evaluation of Cytotoxicity and Genotoxicity www.biologie-lfhk.cz of the surfaces of biological samples. departments and institutions from Germany for Legislative Purposes.

6 Based upon Special Section published in Scientific American Czech Edition Charles University Faculty of Medicine in Hradec Králové, www.lfhk.cuni.cz 7 Faculty of Medicine in Hradec Králové Charles University Department of Physiology Department of Histology and Embryology

Modern instruction on how organisms work The traditional approach to practical physiology teaching based upon animal expe- A unique means for studying tissues riments is already a thing of the past. Ethic, legislative, economical as well as scienti- fic reasons have caused a significant limitation to experiments on animal mo­dels not and cells only in our country but worldwide. We either use alternative approaches when mea- A histologic approach is irreplaceable when examining tissues and multicellular suring, observing and carrying out non-invasive experiments on human volunteers, structures grown in 3D cell cultivations. Understanding the histological structures of which means on the students themselves, or other alternatives represented by com- normal tissues is a prerequisite for the study of physiology and pathology. This field puter programs that simulate chosen physiological processes. is demanding on the imagination as we have to link the view of the studied structure from the light microscopic level to its ultrastructure and at the same time we have to “Physiology of today is the medicine of understand the three-dimensional arrangement of its building components. For this “Stem cells are not only the first but also tomorrow.” (Ernest Henry Starling) purpose, we use a three-dimensional reconstruction of cells and tissues. In their prac- the most extraordinary cells of our organism.” Prof. Zuzana Červinková, M.D, Ph.D. tical coursework students now have the chance to make their own digital images of Head of the Department of Physiology tissues and to use them together with interactive e-courses during their self-study. Prof. Jaroslav Mokrý, M.D., Ph.D. Head of the Department of Histology and Embryology

Transplantation of stem cells The spectrum of research A broad interdisciplinary approach To evaluate the extent to which the stem cells or their methods Physiology taught with the help of simulating Highly effective oxygraph Oroboros-2K descendants are involved in tissue regeneration, we use computer programs We prepare histologic samples, slices for the experimental endeavors of students transgenic cells containing green fluorescent protein The laboratory of tissue cultures provides facilities for (for example paraffin-embedded, semi-thin from other fields of natural science, prepa- (GFP) during transplantation. This endogenous marker research into the primo-cultures of hepatocytes isola- or ultrathin for transmission electron ration of their bachelor or diploma theses or makes it possible to distinguish the donor's cells from the ted from rodents. Many fluorometric methods have The team of experimental hepatology microscopy), special staining of tissues (his- even for PhD dissertations. We are also ex- issue of the recipient once the healing has taken place. been introduced to evaluate the functional status of A histologic examination enables the analysis of the cells. Microscopes with phase contrast and fluo- tochemical or immunohistochemical detec- panding our contacts abroad. Our postdoc- changing expression of characteristic features in trans- rescent microscopes enable researchers to evaluate Under the leadership of Professor Čer- toxic liver damage, sensitivity of the liver to tion), microscopic examination, description toral fellows do their research fellowships, planted as well as recipient's cells and allows for the crea- cellular morphology and characteristics. The bioener- vinková, the team has the long term goal of re- hepatotoxic substances and the regenerative and interpretation of findings, image ana- for example, at the University of Oslo, Sin- tion of a three dimensional reconstruction of the trans- getic laboratory, which is equipped with multifunctio- response of the liver when affected by a non- lysis as well as taking micro-photographic gapore or Galway (Ireland) and their re- plant. Another important aspect is the observation of cells nal high-resolution (Oxygraph-2k Oroboros), permits searching toxic liver injury, including mecha- nisms of the impact of model hepatotoxins alcoholic fatty liver disease (NAFLD, NASH), images. We also have laboratories for culti- search topics range from research of stem in time (which informs us whether the transplanted cells simultaneous measurements of mitochondrial respira- are fulfilling only temporary tasks during healing or tion and mitochondrial membrane potential. It is possi- and substances with a possible hepatoprotec- extrahepatic cholestasis induced by ligation of vation of (stem) cells and a laboratory for and cancer cells to the analysis of mito- whether they substitute fully the original damaged popula- ble, in cooperation with other work places, to relativize tive effect. Furthermore, we research liver re- d. choledochus and the further possibility of af- molecular morphology. We provide a base chondrial complexes. tion of cells) and their distribution in the whole organism. immunohistochemical methods and to use radioactive- generation induced by partial hepatectomy or fecting liver damage (for example by statins). ly marked substances for evaluating the proliferation activity of hepatocytes. The methods of proteomic analysis of myocardium in animals has also been intro- Metabolism of proteins and amino acids The first in Central Europe duced. Radio-isotopic methods and HPLC permit the evaluation of proteosynthesis, proteolysis, and the This research is led by Professor Holeček ments recommended to induce positive pro- Traditional research topics at our de- analysis, we study the tissue microenviron- metabolism of amino acids. and is focused on experimental studies into tein balance in costal muscles and the partment are the healing of tissue lesions, ment (niche) of stem cells in the subepen- the metabolism of amino acids in relation to importance of changes of aminoacidemia in including regeneration of axons and angio- dymal layer during the neurodegenerative Kupffer cells (green) generated in the liver 70 days after bone marrow stem cell trans- Contact: the pathogenesis of proteocatabolism in dis- the pathogenesis of liver encephalopathy. In genesis. The appearance of new methods of process in striatum caused by Huntington's plantation (in cooperation with the Clinic of addition, Professor Holeček’s research in- disease. We also use animal models for ob- Charles University eases complicated by cachexia (acute and isolating tissue specific stem cells has ex- Oncology and Radiotherapy). The nuclei of chronic conditions of the liver, renal insuffi- terests for many years have focused on ami- panded this scope. In 1995, we became the serving cell participation in the healing of the cells are labelled blue. Faculty of Medicine ciency, sepsis). A further focus of the re- no acids with branched-chains and glu- first institution in Central Europe to intro- tissues, for example regeneration of muscle Contact: in Hradec Králové search is the side effects of nutrition supple- tamine. duce the method of isolating and cultivating tissue which we induce via local injection of Charles University Department of neural stem cells and characterizing their cardiotoxin, while irradiation (either local Experimental cardiology behavior and differentiation potential in or of the entire body) serves for suppressing Faculty of Medicine Physiology vitro and after transplantation in recipients. a hemopoiesis and immune response of or- in Hradec Králové Associate Professor Adamcová is a lead- dio-toxic and cardio-protective effects of We provided the findings from our research ganism. With the availability of pluripotent Department of Histology Šimkova 870 ing person in this field in our department. new drugs, and on predicting the develop- to other work places and we used them as cells, the possibility of modelling the growth 500 38 Hradec Králové Her work is closely linked with the research ment of anthracycline cardiomyopathy with well during the research of other types of of tissue in 3D cultures has begun to appear, and Embryology Tel.: +420 495 816 124 of the cardiology group from the Depart- the help of biomarkers of cardiac damage. stem cells and progenitor cells, for example as has the study of signalling pathways in- Šimkova 870 E-mail: [email protected] ment of Pharmacology. Her present re- Further research involves the problem of re- cells from bone, dental pulp and periodon- volved in the regulation of self-renewal and 500 38 Hradec Králové search activities are focused on the study of modelling the myocardium under various tal ligaments, and ES and iPS cells. We have the differentiation of cells. The application Tel.: +420 495 816 291 www.lfhk.cuni.cz/ the cardiotoxicity of antineoplastic sub- pathological conditions and the possibility received funding for the research of mesen- of knowledge of such regulation to a guided E-mail: [email protected] physiology stances, namely on the use of cardiac tro- of influencing pharmacologically hypertro- chymal cells within the 7th framework EU differentiation can enable in vitro genera­ ponins T and I in the evaluation of the car- phy and fibrosis. program called Purstem. Besides in vitro tion of any cell type.

8 Based upon Special Section published in Scientific American Czech Edition Charles University Faculty of Medicine in Hradec Králové, www.lfhk.cuni.cz 9 Faculty of Medicine in Hradec Králové Charles University Department of Hygiene and Preventive Medicine Department of Languages For the better health of the population The field of hygiene and preventive medicine is an inseparable part of curricula at all The basic means of communication medical schools. It deals primarily with specific and nonspecific primary prevention, The Department of Languages is responsible for specialized language preparation including the evaluation of health risks. Specific primary prevention focuses on specific of students of medicine in all master’s degree and bachelor’s degree programs. In ad- risks and diseases (health prevention). Nonspecific primary prevention includes the over- dition, we organize examinations of students in the doctoral study program and tests all strengthening and development of health (support of health). The objective of hy- of language skills for applicants who want to participate in the fellowship program at giene and preventive medicine is to protect and support health in terms of activities and the prestigious Mayo Clinic, Rochester, USA or other in- measures that will create and protect healthy living conditions, prevent the occurrence ternships within Erasmus and other EU programs. We and spread of infectious diseases and epidemics and other significant health disorders. also regularly organize tailored evening language class- “Fools keep making the same old mistakes; The field closely cooperates with other branches aimed at epidemiology as well as with es for employees and students. “It is never too late to start.” clever people keep making new ones.” fields focused on diagnosis and treating diseases which appear on a mass scale and An important role which the Department of Languag- Jan Comorek, Ph.D., Ph.Dr. Prof. Zdeněk Fiala, M.Sc., Ph.D. which are preventable and of a determined nature. es plays, in addition to teaching, is expert translations Head of the Department of Languages Head of the Department of Hygiene and proofreading of various articles, essays or other texts and Preventive Medicine for the staff of the Faculty of Medicine or the University Czech in the hospital, medical Hospital and other specialists from all fields of medicine. Czech and Czech for advanced Cooperation Though the work of the department is very diverse students and wide, its basis has always been and still is the man- A large part of our research is undertaken in cooperation Subjects lasting one term (Czech in the Hospital, with theoretical and clinical worksites at the Faculty of datory language preparation of students. In Czech pro- Medical Czech, Advanced Medical Czech) are a follow- Medicine in Hradec Králové and the University Hospital grams, mandatory courses of English are taught and, up of a basic two year course of Czech for international Hradec Králové. Other significant cooperation involves vice versa, in English language programs Czech is students. These courses practice and deepen language skills and focus on doctor–patient communication. The the Department of Physical Education at the University taught. In both the Czech and English language pro- topics correspond with topics in the specialized sub- of Hradec Králové, the School of Health Studies at the grams students must take mandatory courses in Latin University of Pardubice, the Regional Hygienic Station jects taught at the hospital. The aim is to develop good of the Hradec Králové Region and the Health Institute in medical terminology. language competence in students so that they can be Hradec Králové. able to communicate with patients and take the patient’s history. We consider speaking, active usage English – indispensable at every step of language and listening to be the most important language skills. To improve the language competence English is taught as a mandatory subject read bibliographies in English, and present re- of students and widen the word stock the latest teach- and is taught as ESP (English for Specific Pur- sults of scientific work in English. The courses ing technologies are used during the classes. Toxicological laboratory poses). The focus of the course is specialized are held in the third study year and thus the medical vocabulary in all basic medical fields. student can bring to the study of Medical Eng- Everyone who finishes the course will be an lish knowledge gained in theoretical subjects Assessment of the level of health risks active user of medical English, will be able to during the first two years of study. Analysis of chromosomal aberrations of We are focused in the long term on the the function of the immune system. Other Latin – the basis for medical terminology peripheral lymphocytes (50x). toxicology of polycyclic aromatic hydrocar- research directions that have to be men- bons. The research is aimed at the study of tioned are the study of biological interactions Latin has always been a traditional part of classes for all programs in the first year of Contact: their absorption and how they influence in mixtures of substances, the parameters of medical education. Even today Latin medical study. The contents are the medical Latin and Charles University genotoxic and epigenetic mechanisms of mu- the kinetics of dermal absorption, the eval­ terminology is an inseparable part of the stu- Greek necessary for a good understanding of Contact: tagenesis and carcinogenesis through bio­ uation of low frequency noise and their effect dents´ knowledge – the knowledge of future theoretical subjects like anatomy and later for Faculty of Medicine Charles University transformation. In addition, we focus on the on health and also mathematical models for doctors and nurses. The department organizes successful use in the medical practice. Faculty of Medicine in Hradec Králové observation of post-exposition changes in substances carried on the air. in Hradec Králové Department of Hygiene Department of and Preventive Medicine Population study Languages Šimkova 870 We focus on perceiving and objectifying stress. The studies we perform are also Šimkova 870 500 38 Hradec Králové health risks resulting from specific life- aimed at observing the quality of life in var- 500 38 Hradec Králové Tel.: +420 495 816 244 styles, personal or family strain, and/or ious profession groups of healthy patients. Tel.: +420 495 816 536 E-mail: [email protected] work. Within the study on work risks, we Particular attention is devoted to parame- E-mail: [email protected] www.lfhk.cuni.cz/hygiene use questionnaires – a traditional method – ters evaluating the quality of treatment and and we quantify it by analyzing the level of preventive care and their effect on the qual- www.jazyky-lfhk.cz/en saliva cortisol as an indicator of chronic ity of life of senior citizens.

10 Based upon Special Section published in Scientific American Czech Edition Charles University Faculty of Medicine in Hradec Králové, www.lfhk.cuni.cz 11 Faculty of Medicine in Hradec Králové Charles University Department of Medical Biophysics Department of Medical Biochemistry Rich clinical coursework We have succeeded in introducing clinical biophysics classes that focus on clini- The chemistry of life cal examination and evaluation in which students have the opportunity to examine Chemistry and biochemistry have always been and perform medical evaluations on each other with the use of diagnostic devices like among the basic theoretical subjects from the be- perimeters, audiometers, refractometers, ultrasound, EKG, and others. This type of ginning of the Faculty of Medicine. Because of the clinical class has been introduced within the last ten years with the help of several de- worldwide development in this field, biochemistry velopment projects. The student laboratory represents a virtual doctor´s office in has come to dominate and the role of chemistry which students are in the role of patients as well as examining doctors. Each labora- has diminished to the basic necessary of under- tory examination and measurement thus simulates one examination, including writ- standing the biochemical processes. We have “Words are not counted but weighed” ing notes in the patient´s file in an outpatient information system. The data obtained gradually introduced seminars into the classes “He who knows nothing, doubts nothing.” are processed by the students and then stored into this system in the format that is which, together with laboratory classes, provide Assoc. Prof. Josef Hanuš, M.Sc., Ph.D. Prof. Martina Řezáčová, M.D., Ph.D. Head of the Department of Medical Biophysics usual and common in normal medical practice. the students basic information on metabolic pro- Head of the Department of Medical Biochemistry cesses in organisms and give a good foundation for understanding pathology. Biochem- We cooperate istry is a dynamically developing field and a lot of new crucial information must be in- The study of new troduced into classes. For this reason, we welcome the possibility of introducing elec- antineoplastic substances and We cooperate with the ELLA-CS company, which was tive subjects. In cooperation with clinical workplaces we have introduced a subject founded by a former department member, Assoc. Prof. their drug combinations Karel Volenec, M.Sc., Ph.D., and together we have par- devoted to the pathobiochemistry and metabolic disorders. Other subjects include The effort to find more efficient antineoplastic treatment ticipated in a research and development of special pathobiochemistry of cells and toxicology. All of these elective courses are avilable in or to lower the side effects of traditional therapeutic treatment products (stents from materials with a English as well. To make up for any lack of knowledge from secondary school, we offer drugs means searching for other approaches, including shape memory) and miniature multi-thermic cells for our students the elective subject of Basics of Chemistry. the study of new potentially effective substances and hyperthermy. Large measurements for the company their combinations with already well-established treat- Another aspect of our department is the teaching of future dentists. A portion of the ELLA-CS have been accomplished in cooperation with ment methods. The antineoplastic effect is also observed the Institute of Metallic Materials and Corrosive biochemistry hours is dedicated to the newly introduced subject Materials for Dental systemically on laboratory animals. Furthermore, the Engineering at the University of Chemical Engineering Medicine. First, the students experiment and work in the chemical laboratory with ba- pharmacokinetics of substances is observed in experi- in Prague. We have measured mechanic characteris- sic stomatology materials. They then continue to work in the phantom laboratories of mental animals during physiological and pathological View of student laboratory and examples of examination tasks. Top-left view – “measuring tics of wires from materials with shape-memory the Department of Dentistry. states. To evaluate such observations, we use liquid exposed to heat and chemicals for the purpose of opti- erythrocytes”, bottom-left – “audiometry”, top-right – “perimetry”, bottom-right – “refractometry”. chromatography analysis or mass spectrometry. For many years we have also organized secondary school competitions at various mizing the technology of their thermic processing dur- ing vessel reinforcement production. levels. We also participate in preparatory courses for study at our medical school. Research Mechanisms of cell death and reparation of DNA As for research, the department focuses complex structures with the use of fluores- namely on applied research and development cence. The measuring systems are fully auto- Our interest in the problematics of mo- lecular damage can be seen in our long-term in cooperation with clinical working places matic and computer controlled with the use lecular mechanisms initiated by DNA mo- cooperation with the Department of Radio- and regional producers of medical and health of our own software or the use of a modular biology at the Faculty of Military Medicine technology (ELLA-CS). We have gradually system from National Instruments and the at the University of Defense. The effort to ex- succeeded in constructing and equipping a LabVIEW laboratory. For the purpose of pand our knowledge on the molecular basis Detection of premature senescence of stem Associate Professor Karel Volenec, M.Sc., laboratory specialized in measurements and modelling and simulations, we use compati- of the reaction of living organisms to ioniz- cells induced by ionizing radiation. Ph.D. – A common seminar with the company ELLA-CS research and equipped with unique devices ble programs such as Comsol, Matlab and ing radiation exposure has resulted in re- Contact: and measuring systems or apparatuses of our Simulink. The outcome of our research work search focusing on the study of intracellular Contact: Charles University own construction, specifically the Instron in this field is, besides many publications, 6 signalization as a reaction to DNA damage Faculty of Medicine Charles University system for measuring the load characteristics industrial designs which were accepted and by ionizing radiation or by cytostatics, re- Faculty of Medicine of materials or medical and medicinal proto- recognized by the Industrial Property Office search on observing repairs of double-strand in Hradec Králové in Hradec Králové types made of such materials. Examples of in 2009, 2010, and 2014. breaks in DNA caused by these noxae, cell Department of Medical such products are various reinforcements, fil- Detection of double-strand breaks in DNA in cycle regulation, and the induction of apop- Biochemistry Department of Medical ters or orthodontic springs and arches. The lymphocytes of a patient after radiotherapy tosis and senescence. Biophysics system is complemented by a special heated Šimkova 870 air chamber with a Julabo thermostat for test- 500 38 Hradec Králové Šimkova 870 ing materials with shape-memory. In addi- Proteins of connective tissue and expression of Tel.: +420 495 816 295 tion, we have developed a special measuring 500 38 Hradec Králové appropriate genes E-mail: [email protected] device of our own construction for measuring Tel.: +420 495 816 247 the load characteristics of stents, a Nikon Our third traditional research area is the metabolism in connective tissues. We study www.lfhk.cuni.cz/ E-mail: [email protected] ima­ging system for analyzing the surface A NIKON microscope – measuring the geometry study of connective tissue and fibrogenesis. the influence of extracellular matrix on the biochemistry characteristics of materials or studying more of orthodontic devices from intelligent materials. Many diseases are connected with a changed behavior of normal and carcinoma cells.

12 Based upon Special Section published in Scientific American Czech Edition Charles University Faculty of Medicine in Hradec Králové, www.lfhk.cuni.cz 13 Faculty of Medicine in Hradec Králové Charles University Department of Social Medicine Department of Pharmacology For a healthier society Social medicine is an interdisciplinary medical field which connects the health sta- Teaching in the digital age tus of an individual patient or a group of patients with a certain disease. It studies the We have gradually created and continuously upgrade study texts available to our health of the population and the care of health within the framework of the whole soci- students at the webpages of our department, and have introduced three supporting ety. It asks three basic questions: What is the health of the population? Why is it so? computer applications. The first such appli- What can improve it? cations were interactive presentations pur- When we began to teach this subject field in English, we had to adapt the curriculum chased from the companies Pharmac-a-logy so that it was culturally sensitive and provided students with the opportunity to study and Pharmatutor. They provide students various approaches to systems of health care so that the students could show fellow illustrative presentations of indivi­dual pro- “Health is not everything, but anything classmates the specifics of the health care in their home country. blems in the field. This has been closely rela- “Primum non nocere.” without health is worthless.” We endeavored to highlight three important aspects. The first concerned linking so- ted with the usage of computer simulations Prof. Stanislav Mičuda, M.D., Ph.D. Assoc. Prof. Svatopluk Býma, Ph.D. cial medicine with clinical medicine and clinical fields. The second was close coopera- which have gradually replaced demanding Head of the Department of Pharmacology Head of the Department of Social Medicine tion with preventive medicine (see the topic of the type of citizen´s heath) and the third experiments on animals or on isolated or- was, and still is, how the patient or individual views his or her own state of health and Cardiovascular pharmacology laboratory gans and help demonstrate the mechanisms The role of chosen enzymes National standards healthcare. The interest of students had been gradually of the effect of the chosen drugs or their and transporters in and recommendations rising, and when some 95% of students signed up for the pharmacokinetics. The third supporting pharmacokinetics and the optional state exam in social medicine (involving defend- application are case reports from clinical pharmacodynamics of drugs. National accreditation standards have been created ing of a thesis – not a very common practice at other practice which were prepared in coopera­ for medical institutions which provide preventive We deal mostly with the problem of the excretory func- healthcare in the field of general practice. We continu- medical schools), the management of our faculty decid- tion with specialists from individual clinics tions of the liver and kidneys and their alternations ously work on individual guidelines (recommenda- ed that the state exam in this subject will again become and presented in the form of interactive web during various liver or systemic diseases. In connec- tion with this we also evaluate the potential protective tions) for general practitioners in terms of the treat- compulsory for all students, including those from abroad. A classroom for teaching nursing applications describing solutions to specific ment of serious illnesses. effect of certain statin drugs, corticosteroids or pharmaco-therapeutic situations. All the antagonists of IL-1 receptors as well as natural sub- elective in the summer term of the 5th study created teaching materials are at present stances, for example resveratrol or epigallocatechin General medicine gallate. New methods year. At the end of the 5th study year, the Analysis of drugs and metabolites on a fluid available on our faculty´s secure server – chromatography with a mass detector moodle.lfhk.cuni.cz. Recently, new electronic versions of patient question- The Department of Social Medicine pro- students go for a week-long stay at a general naires have been introduced into clinical practice. vides instruction for students of general med- practitioner of their own choosing. At the These questionnaires con- icine. Classes are held in the winter terms of end of the 6th study year, the whole subject is Cardiovascular pharmacology cern the patient’s percep- the 2nd and 5th study year. For those who are reviewed and appears as part of the state tion of his or her illness (IPQ-RCZ), the meaning of interested, we also offer this subject as an exam on preventive medicine. We study cardiovascular toxicity of anti- the illness (MIQ-SRCZ), neoplastic drugs with the potential of phar- and an original question- Nursing macologic cardioprotection. While in the past naire on the quality of life cal program and, in cooperation with the we have focused on clinically significant car- in women with physiologi- The Department of Social Medicine, University Hospital, in the first through diotoxicity of anthracycline antineoplastics cal gravidity (QOL-GRAV). within the framework of a separate division, third year of the bachelor’s degree program in (for example, doxorubicin or daunorubicin), teaches students in the 2nd year of the medi- General Nursing. recently we have chosen to investigate specific Contact: biologically-aimed drugs (for example, Suni- tinib or inhibitors of proteasome). We are fo- Charles University Principal research programs Evaluating the presence of Mdr1 transport cusing mainly on in vivo research into the protein in the liver Faculty of Medicine The main research program is the psycho- The third research program, begun in chronic forms of cardiovascular toxicity of Contact: in Hradec Králové social and medical problems of children and 2012 and still being undertaken, is financed these abovementioned drugs in laboratory an- adolescents. We do research on pain in chil- by the PRVOUK 37/09 project of the Anthracycline cardiotoxicity in an experiment imals (rabbits, rats and mice). Charles University Department dren, how adolescents and children cope with Charles University. It focuses on the psy- Faculty of Medicine of Social Medicine difficult situations, social support for children chosocial and health problems of senior cit- Research in clinical pharmacology in Hradec Králové and adolescents, and the quality of life in chil- izens. Šimkova 870 dren and adolescents. Another focus of re- The fourth research program, begun in We focus on the usage of individual and University Hospital Hradec Králové on the Department 500 38 Hradec Králové search is a broad international study financed 2007 and still active, is devoted to improving population modelling of pharmacokinetics, topic of methotrexate in curing focal psoriasis. of Pharmacology Tel.: +420 495 816 426 by the World Health Organization – Health the work of practicing doctors. We studied pharmacodynamics, and bio-indicators of Other areas of clinical pharmacology research Šimkova 870 E-mail: [email protected] Behavior in School-Aged Children, 2010. the approach of general practitioners to the therapeutic and toxic effects of drugs for are the treatment of idiopathic juvenile 500 38 Hradec Králové The second research program, which ran prevention of cardiovascular and gastroin- individualization in pharmacotherapy. In the arthritis, Crohn’s disease, and the usage of www.lfhk.cuni.cz/ Tel.: +420 495 816 233 social‑medicine from 2009 to 2011, concerned psychosocial testinal diseases (an international compara- field of clinical pharmacology, we have been non-invasive methods of examining bio- problems in the adult population, specifically tive study in the countries of Middle and cooperating for 15 years with the Department indicators in respiratory tract disease with E-mail: [email protected] how individuals viewed their own illnesses. Eastern Europe). of Dermatology and Venereology at the inflammation.

14 Based upon Special Section published in Scientific American Czech Edition Charles University Faculty of Medicine in Hradec Králové, www.lfhk.cuni.cz 15 Faculty of Medicine in Hradec Králové Charles University Department of Pathological Physiology Academic Department of Internal Medicine

When and how disorders occur in the body In the curriculum of General Medicine at our Faculty, pathophysiology comprises For healthy viscera 157 instruction hours in the 3rd study year before students move on to clinical course- The department provides instruction for the Charles University Faculty of Medicine work in the fourth year. Pathophysiology is quite unique as it does not have to introduce in Hradec Králové. It includes eleven divisions pertaining to the particular fields of inter- many new facts but has to teach (force!) the students to integrate their theoretical nal medicine and six departments. The Academic Department of Internal Medicine cur- knowledge to understand the origins (etiology) and development (pathogenesis) of dis- rently has 18 professors, 15 associate professors, 30 assistant professors, and 51 teach- eases so that those diseases (or their complications) may be prevented or adequately ers with a scientific degree (Ph.D. or D.Sc.). treated. In our instruction a comprehensive (global, holistic) approach is maximally applied Divisions blood clotting and all the factors that con- “Laws should not force us to act against to help students understand the basics of the disease. Such an approach is often mis- tribute to clotting. Prof. Jan Bureš, M.D., Ph.D. common sense!“ takenly considered to be the exclusive domain of alternative / complementary medi- Head of the Academic Department of Internal Clinical Biochemistry Prof. Miroslav Kuba, M.D., D.Sc. cine. Pathophysiology is a field that can be very unpleasant for students who are accus- Angiology Medicine Head of the Department of Pathological Physiology tomed mainly to memorizing facts. However, it is always better for the patient if the doc- Head: Associate Professor Radovan Malý, Head: Associate Professor Pavel Živný, M.D., tor does not mechanically apply the “best clinical practices“ (guidelines). During the M.D., Ph.D. Ph.D. Departments: From research to practice final oral exam, students are evaluated not only in terms of their knowledge but also in We teach diagnostics and non-surgical Our interest lies in the fundamental bio- 1st Department of Internal Medicine – chemical processes in the human body in Cardioangiology In the context of the 36th worldwide symposium of terms of how trustworthy they would seem to be as doctors. treatment of diseases of arteries, veins, and ISCEV (International Society for Clinical lymphatic vessels. terms of human health, treatment of dis- 2nd Department of Internal Medicine – Electrophysiology of Vision) which took place in 1998 eases, their diagnostics and prevention. Gastroenterology in Hradec Králové, we gave a presentation on imple- Diabetology 3rd Department of Internal Medicine – Metabolic Cardiology menting “motion-onset visual evoked potentials” in Electrophysiology Head: Associate Professor Alena Šmahelová, Care and Gerontology Head: Associate Professor Josef Šťásek, M.D., diagnostics. We have obtained three patents (EN 303 M.D., Ph.D. 4th Department of Internal Medicine – Hematology 192, EN 304 875, EN 304882) and have registered a of vision Ph.D. Our division specializes in the prevention, Department of Pulmonology utility model for a device allowing a wider application The electrophysiology laboratory current- diagnostics, and treatment of diabetes mel- Our responsibilities involve the diagnostics of this method. Currently, we are trying to ensure its Department of Occupational Medicine ly represents the main aim of the depart- and of heart defects, ischemic dis- mass production. litus, including potential complications as- ease, heart failure, disorders of heart rhythm, Individual departments are introduced in the following ment’s research and involves pursuing new sociated with the disease. pages. variants of visual evoked potentials and cog- and other heart diseases. Endocrinology nitive brain potentials, especially during dif- In December 2014, Head: Professor Jan Čáp, M.D., Ph.D. Nephrology ferent variants of motion stimulation, with a new edition of We deal with the diagnostics and treat- Head: Professor Sylvie Dusilová Sulková, testing of their new diagnostic applications. our Textbook of ment of hormonal disorders resulting from D.Sc., MBA Internal Medicine The importance of the laboratory in Czech Examination of visual evoked potentials the malfunction of glands with internal se- We deal with the diagnostics of kidney dis- (two volumes, clinical neurophysiology is documented by 1275 pages) was cretion (directly into the bloodstream). The eases and their treatment, kidney trans- the fact that Assoc. Prof. Kremláček is the of the Czech Medical Association of J.E. published. The most common problems of this sort include plants, and dialysis. We pay attention to the president of the Neurophysiological Society Purkyně. authors of the thyroid disorders. systemic conditions that affect the kidneys textbook were (such as diabetes or autoimmune diseases) associate Mobile device to monitor brain functions Immunotoxicology analysis (methylation of the p53 protein), and Gastroenterology and systemic problems that result from im- professors and protective capacity (25-hydroxes of D vita- Head: Professor Stanislav Rejchrt, M.D., Ph.D. proper kidney function. professors of the Charles University Faculty of Medicine in CONTACTS: Since 1997, research in immunotoxicology min). Furthermore, we investigate the patho- We focus on the diagnostics and treatment Pulmonology Hradec Králové and University Hospital Hradec Charles University has been the responsibility of Associate Pro- physiology of inflammation in patients suf- of diseases of the digestive tract - from the Králové. fessor Lenka Borská, M.D., Ph.D. It takes fering from psoriasis and associated comor- esophagus to the rectum, including liv- Head: Associate Professor František Salajka, Faculty of Medicine place in cooperation with a number of theo- bidities, focusing on the risks arising from M.D., Ph.D. er disease, diseases of the biliary tract, and CONTACTS: in Hradec Králové retical and clinical departments of the metabolic syndrome. glands such as the pancreas, where digestive We are engaged in research, diagnostics, Charles University Charles University Faculty of Medicine and enzymes are produced. prevention, and treatment of diseases and Department of University Hospital and also foreign institu- disorders of the respiratory system, partic- Faculty of Medicine Gerontology Pathological Physiology tions (Faculté de Médecine – Université de ularly the lower respiratory tract (trachea, in Hradec Králové Head: Božena Jurašková, M.D.,Ph.D. Montréal, National Institute of Occupation- bronchi, and lungs), as well as diseases of We specialize in the causes and effects of Academic Department of Šimkova 870 al Health, Oslo). In the last ten years, re- the pleura and mediastinum. aging, specific diseases associated with aging, Internal Medicine 500 38 Hradec Králové search has focused specifically on assessing Rheumatology and diagnosis and treating such diseases. Tel.: +420 495 816 223 the benefits and risks arising from the Goeck- Head: Associate Professor Petr Bradna, M.D., Šimkova 870 E-mail: [email protected] erman method of psoriasis treatment (phar- Hematology Ph.D. 500 38 Hradec Králové maceutical coal tar with a high content of www.lfhk.cuni.cz/ Head: Associate Professor Pavel Žák, M.D., We deal with the diagnostics and treatment Tel.: +420 495 834 924 polycyclic aromatic hydrocarbons + UV radi- Ph.D. of rheumatic diseases affecting the muscu- pathological-physiology/ E-mail: [email protected] ation). This research includes tests such as The Goeckerman regimen for the treatment of Our focus is on blood and its components, loskeletal system (joints, bones, spine, liga- psoriasis. genotoxicity, oxidative stress, epigenetic especially blood cells. We also deal with ments, and tendons).

16 Based upon Special Section published in Scientific American Czech Edition Charles University Faculty of Medicine in Hradec Králové, www.lfhk.cuni.cz 17 Faculty of Medicine in Hradec Králové Charles University

1st Department of Internal Medicine – Cardioangiology 2nd Department of Internal Medicine – Gastroenterology

In direct contact with the patient The 1st Department of Internal Medicine – Cardioangiology has a long tradition of Top European department teaching internal propedeutics and internal medicine. It has a long tradition of high qual- The department provides education in the master’s degree program in General ity bedside teaching with special emphasis on cardiology and angiology. Echocardio­ Medicine and Dentistry (in Czech and English) and the bachelor‘s degree program graphy and cardiac catheterization lab visits are also part of the curriculum. Postgradu- (Nursing/General Nursing; Physiotherapy). The department was among the first to be ate seminars and workshops are held on a regular basis for physicians not only from the engaged in e-learning and the use of modern information and communication tech- region but from the entire country, such as the popular international workshop held by nologies (projects MEFANET, Moodle, IT-medic). An elective subject “Gastroenterol- the Association of Interventional Cardiology of the Czech Society of Cardiology, week- ogy – Virtual case reports and digestive endoscopy” was opened for interested stu- ly cardiology refresher courses and others. The annual Rokitanski day provides updates dents. The department is a training cen­ “A heart incapable of joy is on recent developments in cardiology in general and on services provided by the de- ter for students in the internal medicine Prof. Marcela Kopáčová, M.D., Ph.D. a wretched heart.” partment. It is organized on a multidisciplinary basis and is always very well attended, doctoral program and offers medical Head of the 2nd Department of Internal Medicine – Gastroenterology Assoc. Prof. Josef Šťásek, M.D., Ph.D. not only by GPs and cardiologists. professionals the highest level of spe- Head of the 1st Department of Internal Medicine – cialized training in internal medicine, Superiority in the Czech Cardioangiology gastroenterology and rheumatology. Republic All for a healthy heart Teachers at the 2nd Department of In- Together with the Department of Radiology at the Faculty of Medicine and University Hospital, we have The Department The department operates with ternal Medicine – Gastroenterology played a significant part in creating a introduced transjugular intrahepatic portosystemic of Sports Medicine two general cardiology wards, one shunt (TIPS) in patients with severe liver disease and student textbook for internal medicine The department plays a significant contributory role in angiology ward, and intensive portal hypertension. This program is exceptional not (2nd revised and expanded edition pub- the cardiology services by providing specialized stress, and high dependency units. We only in terms of longevity (since 1992) but also in tests including CPET for professional athletes and for treat cardiac rhythm disorders Examination of the small intestine (enteroscopy), lished by Galen in 2014). terms of breadth of experience, both here in the Czech Republic and Europe as a whole. rescue team employees like fire fighters, mountain res- and perform cardiostimulator im- mucosal villous protrusions evident cue workers, etc. It is a highly demanded service in the We introduced into practice breath tests using natu- plants, cardiac pacemakers, whole region. ral non-radioactive isotopes of carbon (e.g. for the diag- cardioverter-defibrillator­ im- nosis of Helicobacter pylori infection or gastric evacua- plants, and invasive treatment of Gastroenterology the main areas of interest is comprehensive tion examination), as well as breath tests based on the various arrhythmias with modern diagnostics and therapy of diseases of the determination of hydrogen and methane in the exhaled air. As the first in the Czech Republic, we started to per- equipment such as the CARTO Our department is among the largest small intestine. In 2015, we introduced new form double balloon enteroscopy for examination and system. The Department of Inter- and most technically and technologically methods for treating esophageal achalasia treatment of the small intestine. We are the most expe- ventional Cardiology performs a advanced centers in the Czech Republic. It (POEM – Peroral Endoscopic Myotomy) rienced in the country at using this method. In addition, comprehensive range of the latest diagnostic partment of Non-invasive Cardiology and uses all available tools for modern diagnos- and premalignant conditions of the eso­ we were the first to use biodegradable stents for the and therapeutic procedures at the highest lev- Department of Angiology perform EKG ex- tics. We perform almost 8,000 endoscopic phageal mucosa (radiofrequency ablation) treatment of benign stenoses of the small and large intestines in patients with Crohn´s disease. el. Coronary interventions, bilateral cardiac aminations, Doppler and 2D studies of blood surgical procedures a year, including all the as well as a sophisticated examination of the Capillaroscopy catheterizations and other invasive interven- vessels, stress echo tests including CPET and basic methods of digestive endoscopy and biliary system (SpyGlass cholangioscopy). (microscopic exam- tions like atrial septal defects/PFO, paraval- other investigations. It is equipped with a all therapeutic methods, abdominal ultra- Among non-invasive gastroenterological ination of blood vular leaks and left atrial appendage closures modern 3D echocardiography system. We sonography, linear and radial endoscopic diagnostics, we perform esophageal vessels of the nail are part of routine practice. Furthermore, we also have counselling units which provide ultrasonography, biopsies, and analgesic pH‑metry and impedance, electrogastro­ bed) in a patient with systemic scle- perform endovascular interventions on aortic specialized care. There has recently been a sig- therapy. The endoscopic workplace also graphy, esophageal and anorectal mano­ roderma – irregular arrangement and ecta- and on mitral valves (aortic valve dilation, nificant development in the treatment of pa- provides comprehensive treatment of chole- metry, anorectal biofeedback, breath tests, sia of capillaries (200x magnification). CONTACTS: TAVI and Mitralclip implantation). The De- tients with peripheral vessels disorders. docholithiasis and performs percutaneous liver function tests, liver elastography, and Contacts: Charles University endoscopic gastrostomies (PEG). One of indirect energometry. Charles University Faculty of Medicine Research Faculty of Medicine in Hradec Králové Rheumatology in Hradec Králové 1st Department The department participates in We focus on the diagnostics and treat- or intensive treatment. Rheumatology pro- 2nd Department of Internal Medicine – a number of prestigious interna- ment of systemic connective tissue disorders. vides comprehensive care which includes of Internal Medicine – Cardioangiology tional clinical trials. Clinical re- The work (diagnostics and therapy, research specialized examinations (joint ultrasound search concentrates on, amongst and teaching) of our rheumatologists con- and synovial fluid analysis, capillaroscopy) Gastroenterology Sokolská 581 others, biomarkers in acute coro- cerns systemic lupus erythematosus, system- and the prevention and treatment of osteopo- Sokolská 581 500 05 Hradec Králové nary syndromes, circulation sup- ic scleroderma, inflammatory muscle diseases rosis. The workplace has become a pioneer in 500 05 Hradec Králové port systems, CMR in myocardial (polymyositis / dermatomyositis), autoim- intense pulse treatment of severe rheumatic Tel.: +420 495 834 695 Tel.: +420 495 834 924 and valvular disorders, secondary mune vasculitis, rheumatoid arthritis, anky- diseases, both with the usage of glucocorti- E-mail: [email protected] hypertensions, and out-of-hospital losing spondylitis and other systemic diseas- coids and immunosuppressive drugs or im- E-mail: [email protected] cardiac arrest. Intracardial EKG es requiring highly professional diagnostics munomodulating immunoglobulins.

18 Based upon Special Section published in Scientific American Czech Edition Charles University Faculty of Medicine in Hradec Králové, www.lfhk.cuni.cz 19 Faculty of Medicine in Hradec Králové Charles University

3rd Department of Internal Medicine – Metabolic Care and Gerontology 4th Department of Internal Medicine – Hematology

How does the human body work? Having been established in 1990, the department offers standard instruction in inter- Our team of hematologists and nal medicine. Simultaneously, we teach gerontology, diabetology, and intensive meta- bolic care. The field of intensive metabolic care is new and the instruction is at a very high endocrinologists level and unique in the Czech Republic. Metabolic care, diabetology, and gerontology are The Department of Internal Medicine provides the basis for the sub-department of also taught in the context of specialized and postgraduate training of doctors. hematology and endocrinology at the Charles University Faculty of Medicine. In 2014, board certification exams began to be carried out in both sub-departments. We also provide facilities for instruction and research activities for the Department of Military Versatile care Internal Medicine, University of Defense in Brno. “Wisdom, knowledge and practice.” The department consists of two intensive • diagnostics and treatment of acute condi- “Difficult does not mean insurmountable.” Prof. Luboš Sobotka, M.D., Ph.D. care units, internal and geriatric, and four tions in old age In the hands of a well-coordinated team Assoc. Prof. Pavel Žák, M.D., Ph.D. Head of the 3rd Department of Internal Medicine – standard inpatient wards – metabolic, geri­ • diagnostics and treatment of internal dis- Head of the 4th Department of Internal Medicine – Hematology Metabolic Care and Gerontology atric, diabetological and follow-up care. The eases with a special focus on internal dis- Currently, our department comprises a lymphomas; myeloma; center for hemosta- Developed with us department is a professional and technical eases in old age and the problem of prema- ward for standard hematological, endo- sis; endocrinology). The hemapheresis In new directions base for the Interdisciplinary Diabetes Center ture aging crinological and general-internal care. In center furnishes platelet concentrate, stem Autologous and allogeneic transplant programs and We provide a range of solutions for parenteral and and provides outpatient and inpatient medical • diagnosis and treatment of kidney disease addition, we have a ward section for lower cell collections and performs therapeutic the related treatment of associated complications are enteral nutrition. We have developed methods for paren- also among our research priorities. This research is teral and enteral nutrition into the central and peripheral care with a particular focus on: in patients who require hospitalization, in- level intensive care with isolation for he- plasmapheresis. Clinical hematology is an aimed at early diagnosis of opportunistic infections vasculature, a method of indirect calorimetry for clinical • acute diagnostics and treatment of pa- cluding treatment of patients with acute matologic/oncologic patients following accredited center for therapeutic care of and treating graft versus host reactions. We are one of usage, a unique probe for enteral nutrition (patented, tients with metabolic and nutrition disor- and chronic renal failure undergoing he- chemotherapy and stem cell transplanta- hemophilic patients and specialized hema- the few centers in the Czech Republic which uses extra- manufactured in the former Czechoslovakia), methods ders modialysis and peritoneal dialysis (in co- tion. The personnel are divided into ten to-oncologic care. The laboratories per- corporeal photophoresis to treat such reactions. We for modified starvation in the treatment of type 2 diabe- • intensive metabolic care operation with the Hemodialysis Center, working teams according to their expertise form both routine and highly specialized are also engaged in the treatment of hemophilia, throm- tes, methods for early nutritional support and rehabilita- botic events of unusual localization, and the introduc- tion in acutely ill elderly patients, usage of a two-way • care of critically ill patients with internal University Hospital) (acute leukemia; transplantation; support- hematological examinations. Beds with ra- tion of new anticoagulants drugs. The endocrinology catheter in the treatment of gastrointestinal fistulas of diagnoses and internal complications of • monitoring and managing hospitalized ive care; hemapheresis center; myelodys- dio-hygienic regimes allow for treatment team focuses on the treatment of thyroid diseases the gastrointestinal tract, an ASTRIS dietary computer surgical and traumatology disorders patients following renal transplantation plastic syndrome and myeloproliferative with radioactive medication. We are also a using radioiodine, on pituitary adenomas, and on acro- system, clinical software for intensive care metabolic • caring for patients who require parenteral • treatment of plasmapheresis (in coopera- disorders; chronic lymphatic leukemia; center for nuclear accidents. megaly therapy. The hemapheresis center plays an units, bicarbonate solutions for extracorporeal elimina- and enteral nutrition, particularly in com- tion with HDS) and other extracorporeal interdisciplinary role. In addition to the aforemen- tion methods, new ways to treat wounds, and apheretic tioned routine interventions, therapeutic lipapheresis methods in the treatment of numerous metabolic dis- plicated situations elimination methods, including continu- is used to treat congenital hyperlipidemias. eases. • specialized diagnostics and therapy of ous methods of patients in intensive care metabolic and nutrition diseases (diabe- units tology, obesity, disorders of lipid metabo- • treating intoxicated patients who require lism) elimination methods

Contacts: Hemapheresis Center Charles University Myeloblasts with Auer rods Faculty of Medicine How to treat patients even better Contacts: in Hradec Králové Admission of seriously ill patient Metabolic care and rehabilitation The main research in hemato-oncology is the establishment of a data center. An im- Charles University 3rd Department of focused on developing more refined diag- portant overall change in the field was the Faculty of Medicine Internal Medicine – nostics and treatment using immunological necessity of using molecular-genetic meth- in Hradec Králové Metabolic Care and Research and molecular-genetic methods. Important ods in diagnosing hematological and onco- 4th Department of Internal Gerontology therapeutic advances have been introduced logical diseases. Therefore, even here at the Since the establishment of the depart- in the form of tyrosine kinase inhibitors in University Hospital we have seen rapid de- Medicine – Hematology Sokolská 581 ment in 1990, research has focused on nutri- the treatment of chronic myeloid leukemia, velopment of such methods. In 1997, be- Sokolská 581 500 05 Hradec Králové tion support, metabolic care, and geriatrics. antibodies in lymphoproliferative diseases, sides the ongoing routine autologous trans- 500 05 Hradec Králové This program has been gradually extended and immunomodulation in the treatment of plantation program, the allogeneic trans- Tel.: +420 495 832 271 Tel.: +420 495 834 695 for diabetology, nephrology, and transplan- myeloma. The financial demands in such plant program was launched. In 2015, one E-mail: [email protected] tology. These topics constitute the current procedures have led to an increased number thousand patients underwent transplanta- E-mail: [email protected] research priorities of the department. Research laboratory at the department of patients placed into clinical studies and to tion therapy at our department.

20 Based upon Special Section published in Scientific American Czech Edition Charles University Faculty of Medicine in Hradec Králové, www.lfhk.cuni.cz 21 Faculty of Medicine in Hradec Králové Charles University Department of Occupational Medicine Department of Pulmonology Work and health The department serves as a center for assessing occupational diseases in the Hra- In the interest of lungs dec Králové region. Furthermore, we provide our clients with high quality comprehen- The department is involved in the instruction of students at the Faculty of Medicine sive occupational services, care in the field of travel medicine, and the comprehensive in Hradec Králové and serves also as a postgraduate training center for some special- curative-preventive care of general practitioners. Good health is of the utmost impor- ized procedures. It performs comprehensive diagnostics and treatment of diseases of tance for all human beings and we try to ensure it by preventing its deterioration due to the respiratory system, including intensive care. In addition, it provides specialized coun- unfavorable work environment fac- seling for severe forms of chronic obstructive pulmonary disease (COPD), severe forms tors. We have fully qualified medi- of bronchial asthma, cystic fibrosis in adults, interstitial lung processes and sarcoidosis, cal and nursing staff with many and patients treated with oxygen. The pulmonary oncology care center is part of the “We use our knowledge and experience for years of experience in the field and Comprehensive Cancer Center. The Department of Pulmonology is heavily involved in “I breathe, therefore I am. “ the benefit of the clients“ we have at our disposal quality and the National Research Database of COPD, as well as in COPD research in multicenter Assoc. Prof. František Salajka, M.D., Ph.D. Assoc. Prof. Jiři Chaloupka, M.D., Ph.D. validated diagnostic methods. Our projects of European significance. Doctors at the department are the authors of several Head of the Department of Pulmonology Head of the Department of Occupational Medicine surgeries are therefore equipped recommended procedures for diagnostics and treatment of lung diseases in the Czech with the latest technologies neces- Republic. sary for a comprehensive examina- Bronchology division Center for Travel Medicine tion within preventive care. We In addition to diagnostic bronchoscopies, the broncho- We provide counseling for those planning to travel to provide instruction for students at Pulmonary Intensive Care Unit logy division determines the proper diagnosis for a areas of epidemic risk and areas of problematic variety of diseases of the airways or lung parenchyma the Charles University Faculty of health conditions. We provide health assessment of The Pulmonary Intensive Care Unit is monitors to observe basic life functions by means of methods such as autofluorescence or employees traveling abroad on business, their com- Medicine in Hradec Králové in the designed to care for patients at risk for lung and ventilators to provide invasive and endobronchial ultrasound. Interventional procedures plete care, including mandatory and optional vaccina- field of occupational medicine and failure. In particular, it specializes in the non-invasive ventilation. Doctors at the with laser treatment or electrocautery, endobronchial tions before traveling, medical examination of the stents, and bronchial valves are performed as well. occupational diseases, and post- treatment of acute hypercapnic respiratory ICU have introduced a technique of ultra- state of the traveler’s health upon arriving at his / her graduate training for doctors in the destination, treatment of uncomplicated tropical failure from various causes, in the treat- sound navigated drainages, biopsies, and field of occupational medicine. infectious and parasitic diseases (possible collabora- ment of severe pulmonary infections, and cannulations. A sleep lab monitors pa- tion with the Department of Infectious Diseases), and in thoracic drainage of inflammatory dis- tients with sleep disorders and is a compo- the assessment of tropical occupational illnesses. eases of the pleura. It is equipped with nent of the unit. Outpatient department Standard department We provide occupational health services of medical fitness of employees to perform (preventive care) for contractors (enterprises, work activities, counseling on health risks and We provide diagnostic tests and therapy Examinations for the indication of long- companies, institutions, schools, etc.). We opportunities of preventing occupational dis- for patients with diseases of the airways, term oxygen therapy or prior to transplanta- perform examinations of the health condition eases, supervision of the working environ- lung parenchyma, pleura, and mediastinum. tion are also performed here. of their employees in accordance with the de- ment and working conditions of employees. cision of the public health authority (hygiene The department cooperates with public Oncological Counseling and Cancer Center services) concerning entry, periodic, ordinary, health authorities when assessing occupa- extraordinary, exit and follow-up preventive tional risks and investigating occupational The center provides diagnosis and treatment in patients with lung cancer. There are 5 beds check-ups, workplace inspections, assessment diseases. in which chemotherapy is applied during normal working hours. The patients are in a pleas- ant environment and can spend the time required for drug administration in the company of Bronchology workplace friends and family. After the Contacts: Accurate methods, close cooperation medicine has been adminis- Contacts: Charles University tered, they may return home Charles University Faculty of Medicine In terms of the physiological examination Hospital and outpatient specialists in inter- with their family or be taken Faculty of Medicine in Hradec Králové methods, the department performs EKG, nal medicine, infectious medicine, neurology, home in an ambulance. in Hradec Králové spirometry using the flow-volume curve orthopedics, pulmonary medicine, allergolo- Diagnosis of lung cancer Department of method, water cooling tests and plethysmo­ gy and immunology, angiology, otorhino­ Department Occupational Medicine graphy of peripheral vessels of the upper ex- laryngology, radiology, nuclear medicine, of Pulmonology tremities, screening of hearing with threshold psychiatry, and others. The department also Functional laboratory diffuse lung capacity. We also perform bron- Nezvalova 265 tone audiometry with hearing loss calcula- closely cooperates with a consultant physi­ chial provocation tests as part of the diagno- Sokolská 581 500 05 Hradec Králové tions based on Fowler, otoscopic examina- cian, Jaroslava Vaněčková, M.D., for occupa- The laboratory provides basic examina- sis of bronchial asthma. When desaturation 500 05 Hradec Králové tions, eye examinations using optotypes, and tional skin diseases. tions of pulmonary function using spirome- on exertion has been determined or when Tel.: +420 495 837 514 Tel.: +420 495 834 695 examinations of color perception. When assessing the conditions for the on- try (flow-volume curve, bronchodilator test), long-term, in-home liquid oxygen therapy is E-mail: [email protected] E-mail: [email protected] The department closely cooperates with set of occupational diseases, the department and a complete lung function examination indicated, a six-minute walk test (6MWT) is other medical professionals at the University cooperates with public health authorities. with pulmonary plethysmography, including performed.

22 Based upon Special Section published in Scientific American Czech Edition Charles University Faculty of Medicine in Hradec Králové, www.lfhk.cuni.cz 23 Faculty of Medicine in Hradec Králové Charles University Academic Department of Surgery Department of Surgery How to fix what is wrong in the body The Academic Department of Surgery provides training for the Charles University Treating and curing Faculty of Medicine in Hradec Králové. It consists of 5 departments and one ward. We The Department of Surgery in Hradec Králové, with its size and range of activities, teach surgery of the abdominal organs, especially malignancies and benign diseases of is among the largest departments in the Czech Republic. It is an accredited center for the colon and its anorectal region. We deal with peripheral arterial and venous diseases, the education of young surgeons and a research center of national importance. surgery of neck, heart, spine and chest injuries, and bone fractures and other injuries of the limbs. We are interested in new trends in surgery of the skeleton, breast surgery and surgical intensive care. In addition, we teach general methodology of surgery and phys- General surgery and oncosurgery ical examinations of the entire body. The instruction also focuses on diseases of the cen- Assoc. Prof. Milan Kaška, M.D., Ph.D. tral nervous system, its vascular diseases and infection. The students are introduced to We provide care for surgical diseases all types of hernias and stomach surgeries to “Our main goal is the education of young Head of the Academic Department of Surgery the basic issues of and burn treatment, orthopedics, and urology. throughout the digestive tract. We perform treat obesity. We carry out standard operations promising surgeons.” operations both for benign and malignant dis- on the neck for thyroid disorders and malig- Assoc. Prof. Zdeněk Šubrt, M.D., Ph.D. Departments Head of the Department of Surgery Department of Surgery Nursing practice in surgical fields eases. We perform standard operations on the nant thyroid disease as well as operations on Department of Cardiac and Thoracic Surgery esophagus, stomach, duodenum, small intes- the parathyroid glands. We offer specialized Better against bacteria Department of Neurosurgery The subject is approached as a theoreti- troduces the students with basic clinical tine, colon, and rectum. Standard operations care for both male and female patients with Department of Orthopedics We try to predict individually the adequate dosage of cal and practical whole. It is part of a com- conditions and diseases in the surgical on the liver, gallbladder, bile duct, and pancre- mammary gland diseases. In 2015, robotic Department of Urology the particular antibiotics in a dynamically changing Department of Pediatric Surgery plex of subjects on clinical nursing. It in- fields. as are also performed, as well as operations on surgery was launched. volume of body fluids and in the presence of a series of co-variables so as to achieve effective concentra- Particular departments are introduced on the follow- tions against sensitive bacteria. ing pages. Summer program at the University Hospital – Surgery Degenerative spine disease Accident surgery For more effective treatment Students in their 4th study year attend a wards in the Czech Republic and abroad. We evaluate the effectiveness of multimodal therapy in This elective subject helps develop basic knowledge of 10-day (2-week) program at the clinical Students get to know standard wards, out- We provide acute treatment, and check- tics, operating theaters, intensive care the anatomy, physiology, pathologic physiology, and patients with liver metastases from colorectal malig- biomechanics of the spine. In addition, it expands stu- workplaces of the Academic Department of patient departments, operating rooms, and -ups of adult patients with injuries. For the units, and standard inpatient wards. After nancies and we compare it with the national data. We dent knowledge on clinical examinations of the spine, Surgery or, by agreement, at other surgical intensive care units. treatment of serious injuries, the surgical securing life functions and initial assess- monitor parametrically the quality of TME in order to radiological examinations methods, and the essentials core team is extended by specialists of ment, patients are admitted to expert work­ reduce local recurrence after operations on rectal car- of indications for neurosurgical treatment. The teachers cinomas. We look for adequate, easily accessible and focus on clinical examinations of the spine, synthesis of other expertise in order to build a multidis- places according to the type of injury and Pre-state examination program in surgery non-invasive laboratory indicators which will be pos- the clinical findings and its imaging using radiological ciplinary team with defined tasks and com- the type of care needed. When discharged, sible to use for testing the demands of operations or methods, and provide instruction on the principles of In the 6th study year, students prepare dents are actively involved in the work at the petences for which the trauma surgeon the patients come to the outpatient injury good choice and the scope of surgical treatment. other procedures on intestinal tissue, the functional for the state exam in the individual depart- bed side, in the outpatient ward, and they bares the responsibility. The admission ward or the specialized counseling ward for reserve of the intestinal mucosa, and the course of Course on suturing and ments of the Academic Department of Sur- assist at operations. They obtain profession- ward is complemented by sites for diagnos- check-ups. regeneration and healing of the small intestine. surgical skills gery and in some regional clinics and de- al experience in the running of the surgical This course, open for 10–15 students in the General partments led by senior consultants. The department and discuss their diagnostic and Medicine program, takes place in the 4th study year pre-state examination program is in the therapeutic knowledge with the teachers. Plastic surgery dical care for complicated hand and facial during the summer semester. The participants have the form of a 2-week stay in which students ac- They also gain knowledge concerning the injury and their consequences. We surgical- possibility to practice the basic suturing techniques on synthetic skin or on the skin or organs of domestic tively attend the wards of general surgery, organization of surgical practice, managing We are involved in the specialized diag- ly treat congenital and acquired tumors, animals within the framework of traditional and endo- traumatology, and vascular and plastic sur- patient care, and have the opportunity to nostics and therapeutic care of congenital both benign and malignant, which mainly scopic operating procedures. At the end of the course gery. One week is spent at the Departments look into some economic concerns associat- and acquired defects, damage and deformi- affect the skin. We treat burns to the extent the students assist in the operating room. of Urology, Cardiac, and Thoracic Surgery, ed with daily surgical practice. Their place- ties, treatment of fresh injuries and their specified by the professional company with- Department of Surgery Contacts: Neurosurgery and Orthopedics. The other ment at the surgical workplaces allows bet- consequences in so far as these conditions in the accreditation of the department. Es- Charles University week is devoted to seminars led by tutor spe- ter preparation for the state exam and helps necessitate plastic surgery. We provide me- thetic surgery is also a part of our workload. Contacts: Faculty of Medicine cialists of the abovementioned fields and smooth the transition from their studies Charles University pediatric surgery and intensive care. Stu- into their eventual careers as physicians. in Hradec Králové Vascular surgery Faculty of Medicine Academic Department Surgery under extreme conditions in Hradec Králové of Surgery We are involved in the specialized diag- arteries due to atherosclerosis. Vascular sur- Department of Surgery In this elective subject, physicians of the assistance. The subject does not repeat top- nostics and therapeutic care for patients with gery also deals with patients suffering from Sokolská 581 Academic Department of Military Surgery ics presented in the lectures on surgery, but chronic and acute disorders of the arteries and varicose complex of the lower limbs and dial- Sokolská 581 500 05 Hradec Králové inform the interested students about possi- rather complements information about veins (including injuries) throughout the ysis patients with chronic renal insufficiency, 500 05 Hradec Králové ble emergency situations that may occur in skills necessary for medical procedures pro- body, with the exception of the coronary ar- for whom we perform arteriovenous fistulas Tel.: +420 495 832 108 Tel.: +420 495 832 108 our country or any other location in which vided in exceptional circumstances or under teries, the ascending aorta and the aortic arch, for connection to the artificial kidney. Our E-mail: [email protected] E-mail: [email protected] our medical experts are often placed in the extreme conditions, e.g. war or natural dis- which are the domain of cardiac surgery. The department provides comprehensive care and context of internationally provided aid and asters. most typical problem we treat is injury to the counseling for patients and their relatives.

24 Based upon Special Section published in Scientific American Czech Edition Charles University Faculty of Medicine in Hradec Králové, www.lfhk.cuni.cz 25 Faculty of Medicine in Hradec Králové Charles University Department of Cardiosurgery Department of Neurosurgery We have only one heart The Department of Cardiosurgery provides a full range of care for patients with How to fix the brain, spine, and nerves problems concerning adult cardiac and thoracic surgery. We provide care for the en- Our teaching focuses primarily on issues of traumatology, tumors, and spondylo- tire region, an area with an overall population between 1 to 1.5 million. The range of surgery. This allows overlapping of topics shared with neurology. The postgraduate cardiac surgeries includes also the latest trends. In recent years we have annually per- students attend the department during compulsory pre-board certification placement formed 800 to 900 surgical procedures. programs. The department is involved in the system of board examinations that take One of the primary responsibilities we have is the teaching of medical students and place at various university departments. We are active in training doctoral students. postgraduate students pursuing specialization in cardiac and thoracic surgery. Seven students at the department are currently involved in scientific research (issues Prof. Dominik and Assoc. Prof. Žáček have published several textbooks. The book on of vascular spasms, gliomas, hydrocephalus, trauma, and brain metastases). “Cardiac surgery teaches humility.” surgery of heart valves has also been published in English and Chinese. In cooperation with doctoral programs of the Academy of Sciences we investigate “Ideas have no borders except those The department has a long-term accreditation for habilitation and professorship problems of ischemic spinal cord lesions using the application of human mesenchy- determined by you.“ Prof. Jan Harrer, M. D., Ph.D. Head of the Department of Cardiosurgery in cardiac surgery and it participates in specialized training (including for board cer- mal stem cells. Prof. Svatopluk Řehák, M.D., Ph.D. tification). Head of the Department of Neurosurgery Advanced techniques and The field of thoracic surgery, led by Petr Habal, M.D., Ph.D., has received accredi- Supporting research programs research programs tation for training in thoracic surgery. Annually, there are about 250 operations on the lungs, mediastinum, and chest wall. Our department has organized several international In recent years the department has fo- procedures for intracranial tumors. Other New options in treatment training events dealing with endoscopic surgery for cused especially on clinical programs of research (lead by Dr. Bartoš) involves resec- In the last 20 years, new technological options have atrial fibrilation. We monitor the inflammatory electrophysiologically controlled navigated tion of gliomas in conscious patients and significantly changed the structure of neurosurgical patients. Rapid development of interventional radio- response during heart surgery with extracorporeal their comprehensive treatment in coopera- circulation and compare them with operations without logy and treatment possibilities in the field of vascu- extracorporeal circulation. We monitor tissue metabo- tion with Dr. Pleskačová from the Depart- lar neurosurgery mean that a greater number of these lism in patients operated with or without extracorpor- ment of Oncology. In cooperation with the patients are treated in cooperation with this field. eal circulation based on the methods using microdialy- Department of Radiology (Prof. Krajina), There has also been a significant increase in spinal sis. We perform mini-invasive video-assisted surgeries we specialize in vascular issues (Dr. Česák, disorder operations owing to improved MRI diagnos- tics and great development in surgical approaches in on the mitral valve (minimally invasive mitral valve Dr. Hobza). In the area of spondylosurgery procedures via right minithoracotomy). We provide backbone implants. This means that many spinal short-term and medium-term mechanical cardiac sup- (Dr. Málek, Prof. Řehák), the Department conditions are now able to be resolved surgically. port for heart failure and ECMO (extracorporeal oxy- of Neurosurgery is among the best. genation for respiratory failure; extracorporal mem- Operation on the aortic valve according to the Restorative surgery of the bicuspid aortic valve brane oxygenation). David procedure (remodelling) Modern examination methods Coronary surgery circulation and procedures using mini-inva- Neurosurgeries are unthinkable without majority of cases, it allowed us to specify the sive (heart friendly) approaches. In this field, good diagnostic imaging. Therefore, during etiology of the lesion as well. In the treatment of ischemic heart disease our workplace participates in the interna- the construction of the new neurosurgical Another major advance in the diagnos- we focus on mini-invasive procedures. These tional grant study CORONARY, organized pavilion in 1971, a large area was dedicated tics allowed the introduction of magnetic include operations without extracorporeal by McMaster University, Canada. to the neuroradiologic ward. resonance imaging (MRI). In comparison In 1978, computed tomography (CT) was with CT scans, MRI reveals significantly Reconstructive surgery of the aortic valve installed here as the first in the Czech Re- more anatomical detail in the brain and spi- Transapical aortic valve implantation public. It enabled us to obtain information nal cord. Nowadays, we cannot imagine sur- These are the so-called valve sparing our department, we have started up the concerning the size, location, and patho­ gery of the brain, spinal cord, and spine Contacts: procedures, out of which the most com- program of the Ross procedure (the re- logical vascularization of brain pathologies, without the information we receive from Contacts: Charles University mon are various repairs of incompetent bi- placement of the aortic valve by autograft which at that time was unthinkable. In the MRI. Charles University Faculty of Medicine cuspid and tricuspid aortic valves and fur- from the pulmonary artery and pulmonary Faculty of Medicine in Hradec Králové ther extensive reconstruction of the aortic valve replacement by homograft). Prof. Jan Technological advances in operating theaters in Hradec Králové valve according to the Yacoub procedure Vojáček, M.D., Ph.D., deserves much Department (remodelling) or operations according to credit for the successful development of We use modern operating microscopes, possible to shift the radicalization of the sur- Department of Cardiosurgery the David procedure (reimplantation). At this program. which allow patient-friendly physiological geries and thus increase the safety of the pa- of Neurosurgery operations during mini-operational ap- tient. A significant shift in the radicalization Sokolská 581 Catheter aortic valve implantation proaches. Electrophysiological monitoring of the surgeries has meant computer neuro- Sokolská 581 500 05 Hradec Králové (Dr. Mužíková) is also important. Extensive navigation, which enables precise localiza- 500 05 Hradec Králové Transapical aortic valve implantation (in- use of extracorporeal circulation and without neutralization operations on the brachial tion of intracranial structures. Endoscopic Tel.: +420 495 833 277 Tel.: +420 495 832 680 troduction of a catheter-based technology into cardiac arrest. This method is the priority of plexus are also performed at the department operations, which are safer for nerve tissue E-mail: [email protected] the valve via the apex of the heart) is a gentle our workplace in cooperation with the 1st De- (Dr. Kanta). Devices such as an ultrasound compared to the traditional neurosurgical E-mail: [email protected] way of implanting the aortic valve without the partment of Internal Cardioangiology. aspirator and laser technology have made it approach, have developed significantly.

26 Based upon Special Section published in Scientific American Czech Edition Charles University Faculty of Medicine in Hradec Králové, www.lfhk.cuni.cz 27 Faculty of Medicine in Hradec Králové Charles University Department of Orthopedic Surgery Department of Urology Teaching associated with practice The Department of Orthopedic Surgery participates in medical education within the Teaching associated with practice Academic Department of Surgery. Students in the General Medicine and Dentistry pro- Instruction in urology is organized as part of the curriculum at the Department of Sur- grams are involved in lectures, clinical exercises and seminars, including internships gery as it is in other surgical fields. Students are taught in the fourth and fifth years of prior to state exams in surgery. The same conditions also apply for foreign students study and then clinical training is provided in the sixth year. The study of urology is or- who are taught in English. The clinic is also frequented by foreign students in the Eras- ganized both in Czech and English and the goal is to teach future doctors basic skills mus exchange program. For those students who are interested in the field of orthope- and the latest treatment methods. Postgraduate training also takes place at the Depart- dics, we organize an optional course where specialists of the clinics lecture and in ment of Surgery. Postgraduate students are not only doctors from the Department of which students can visit the manufacturer of joint replacements and have the possibi- Urology but also from external urological centers. Specialized education has changed lity to be acquainted with the production process of implants. In addition, students can considerably since 2012, and it is provided by separate medical faculties. Starting in “Finis coronat opus.” Assoc. Prof. Pavel Šponer, M.D., Ph.D. practice on models of bones and perform surgery on the models. Part of the training December 2013, we began providing board certification examinations at the Depart- Head of the Department of Orthopedic Surgery Assoc. Prof. Miloš Broďák, M.D., Ph.D. is also specialized in preparing residents. We currently have five residents preparing ment of Urology. Head of the Department of Urology for board certification in orthopedics and traumatology. The clinic also provides pre- paration for board certification for young doctors from other orthopedic departments Transplantation center major research projects was kidney trans- Priority research or other fields. An integral part of graduate education is the organization of regular edu- plantation. In 1961, the department carried Minimally invasive surgery We test different types of biomaterials, such as cell or cational seminars. These are mono-thematic oriented events with the participation of The Department of Urology provides not out the first ever kidney transplantation in We perform laparoscopic, curative urological and oncology operations in the kidney, bladder, and adrenal molecule carriers, for the treatment of musculoskeletal experts from the Czech Republic and abroad, conclusions of which reflect major con- only standard and highly specialized health- the former Czechoslovakia in cooperation glands. Pediatric urology at our department has devel- defects. We pay close attention to a number of diagnos- sequences in clinical practice. care, but it also focuses on research and ex- with leading experts from other depart- tic and therapeutic aspects of bone and joint infections oped a strong reputation, including the most complex as well as participate in PRVOUK, a research project at perimental methods. In the past, one of the ments. Currently, we are the main kidney corrective surgery for severe congenital anomalies. our university. We cooperate with the Academy of Enabling healthy movement transplantation center in the Czech Republic Sciences on a grant oriented toward synthetic biomate- for lower urinary tract dysfunction. Another rials for treating large bone defects. Our cooperation The current priorities include implanta- cal fractures) and soft tissue tumors are research program we are involved in is kidney with the Technical University in Liberec focuses on the tion of joint replacements (mainly hip, knee, treated at the clinic in cooperation with on- transplantation in incompatible blood possibilities for the early detection of arthroplasty loos- ening. We also work with LASAK Ltd. Prague on shoulder) and surgical treatment of the com- cologists and vascular and plastic surgeons. groups. Other research directions of the de- research concerning the regeneration of bone tissue plications of these procedures, including ex- Generally, we use methods of limb-saving partment deal with geriatric surgical treat- following the application of synthetic biomaterials. tensive reconstruction and periprosthetic surgery. In pediatric orthopedics , our prior- ment, including options of prevention, and joint fractures. In the field of general ortho- ities are surgery of femoroacetabular im- increasing the safety of minimally invasive pedics, we perform mainly arthroscopic pro- pingement syndrome, pelvic osteotomies, Kidney transplant – vascular anastomosis operation methods. cedures (treatment of meniscal injuries, re- and complex reconstructions. In addition, Pediatric laparoscopic operation construction of ligaments and cartilage de- we perform foot reconstruction for children Operations: from traditional to robotic fects of the knee, surgery of the rotator cuff and conservative treatment of scoliosis. and instability of the shoulder joint), which Within bone and joint infections, we give The Department of Urology has always enable shorter hospitalization and improved priority to patients with infectious complica- been a leading surgical center, even for the patient comfort. Part of our duties involve tions of joint arthroplasties, with infectious most demanding of surgical procedures. In the diagnosis and treatment of patients with complications of injuries, particularly caused addition, 2016 saw the introduction of robot- malignant tumors of the locomotor system . by resistant bacterial agents, and to patients assisted surgeries at our department. One of Secondary tumors (often causing pathologi- with diabetic foot problems. our major priorities has been cancer surgery and surgical treatment of congenital defects. Hand-assisted laparoscopic surgery Contacts: Our department has a special position in the Charles University treatment of kidney tumors with thrombus Contacts: Kidney tumor before nephroctomy – open surgery Faculty of Medicine extending into the inferior vena cava or into Charles University in Hradec Králové the right vestibule. These procedures are car- Faculty of Medicine ried out in cooperation with cardiac sur- in Hradec Králové Department of geons, and patients are dispatched to our Orthopedic Surgery center from the entire country. In 1971, in Department of Urology cooperation with the Department of Radi­ Sokolská 581 ology, we became the first surgical center in Sokolská 581 500 05 Hradec Králové Czechoslovakia to perform obliteration of 500 05 Hradec Králové the renal artery with inoperable cancer. We Tel.: +420 495 833 566 Tel.: +420 495 833 378 carry out almost all methods of derivation of E-mail: [email protected] Laparoscopic view of kidney with tumor before urine made from the intestinal wall after E-mail: [email protected] resection removal of the bladder.

28 Based upon Special Section published in Scientific American Czech Edition Charles University Faculty of Medicine in Hradec Králové, www.lfhk.cuni.cz 29 Faculty of Medicine in Hradec Králové Charles University Department of Anesthesiology and Intensive Care Medicine Department of Dermatology and Venereology

We share information and experience The department provides teaching of university students in the subjects of First Aid, Teaching: seeing it all with your own eyes Basis of Health Care, Principles of Emergency Care, Nursing in Acute and Critical Con- Dermatology and venerology are taught in the second half of the 4th study year ditions and, since 2010, we offer a separate compulsory subject – Anesthesiology and in the General Medicine program and in the first half of the 4th study year in the Den- Essentials of Intensive Medicine. The department is an accredited workplace of the tistry program. Furthemore, the lectures on dermatology and venereology form a reg- highest level and offers postgraduate specialty training for doctors and nurses. We ular part of the undergraduate program in Nursing. Our students benefit from our ar- also offer postgraduate professional courses and internships for doctors and paramed- chives of color slides of both common and less frequently occurring (and even rare) ical personnel in postgraduate programs. dermatoses. This archive has been used as the basis of our own clinical documenta- We have introduced an educational program to ensure training in the field of anes- tion for today’s way of teaching using computer presentations. Tomáš Suchý, M.D. thesiology and intensive medicine as well as continuous professional training for all Photodermatology and skin topical immunomodulation by phototherapy have “No effort is in vain.” Head of the Department of Anesthesiology and the doctors of our department. We have also become a venue for board certification been included as an elective subject offered to fourth year medical students, provid- Assoc. Prof. Miloslav Salavec, M.D., Ph.D. Intensive Care Medicine examinations in anesthesiology and intensive medicine. Hosting, co-hosting, and pro- ing them with the chance to acquire knowledge of how climate change can effect Head of the Department of Dermatology and fessional contribution to regional and national educational and training events are dermatology. Venereology among the regular activities of the Department of Anesthesiology and Intensive Care The department is accredited for postgraduate training in dermatology and vene­ Examination methods Medicine. reology (including dermatology) and corrective dermatology. Needed everywhere Uniquely established investigative methods include determining the erythema threshold (xenon lamp) and In addition to anesthetic care and intensive care of the laboratory predictions of the therapeutic effect of critically ill patients, physicians at our department Return to a normal life, relieve pain Treating a wide spectrum of conditions methotrexate in cytostatic use for psoriasis. We also participate in the donor and transplantation program. consider important the application of screening tests They provide consulting services in the field of resus- The Department of Anesthesiology and up-to date procedures. The third main task The department provides medical care for termining occupational skin diseases. For dec- in symptomatic hepatic porphyria using the Rimington- citation care, participate in the management and run- Intensive Medicine is among the “younger” of our department is pain management for adults and pediatric patients over a wide spec- ades now, another key aspect of our work has Cripps method for determining free erythrocyte proto- ning of ICUs at other departments and the Emergency departments at the University Hospital and cancer patients. trum of dermatological conditions, in particu- been diagnosing, managing, and monitoring porphyrin, the detection of skin mites (Sarcoptes sca- Department, and provide advanced life support at Faculty of Medicine in Hradec Králové. lar phototherapy of psoriasis, atopic eczema patients with malignant melanoma. Recent biei, Demodex), and the use of fluorescence photody- designated departments of the University Hospital. namic diagnostics to screen for skin tumors (basal cell They also provide education and training in cardiopul- However, the volume and complexity puts and other dermatoses. Within the Hradec technologies such as digital dermatoscopy carcinoma). monary resuscitation at the University Hospital and us at the forefront of all such departments in Králové region, we carry out patch tests for de- have proven beneficial for such activities. provide internal transport of patients with failure of the Czech Republic. The primary mission of Close interdisciplinary cooperation vital functions and those in need of artificial ventila- the department in the area of medical care is tion. Complex pain treatment is provided for patients Treatment by photons and protection against them Furthermore, we treat skin complications caused by to provide anesthetic care (for surgery and at the Pain Clinic and Palliative Care Center at the immunosuppressive in patients following University Hospital. diagnostic procedures) in accordance with Research focuses on photodermatology (photodyna- transplantations, and in cooperation with the current medical knowledge. mic therapy, photoclimatology, phototherapy and photo- Department of Oncology we manage and treat certain The second basic task of intensive care Emergency Department with heliport and Critical protection) and some aspects of viral skin diseases (VZV types of skin carcinomas. We also provide dermato- logical consultations for oncological patients, for medicine is to support failing organs using Care Unit genome), autoimmune blistering disorders, food allergy example patients with skin symptoms of tumor condi- in atopic dermatitis, and epidemiology of sexually trans- tions or clinical skin symptoms related to oncological Helping to advance scientific knowledge mitted diseases. There are ongoing programs like TAČR and biological treatment. (i.e. Color Hours – Individual dosimetry of UV radiation) Publications for teaching and learning Research is carried out both in the clini- findings from experimental studies in hu- and the European program COST (aimed at the preven- Contacts: cal and experimental area. The main topics man medicine, particularly perfusion of the tion of skin and occupational diseases, including skin Charles University include organ perfusion studies, its patho- gastrointestinal tract related to the healing cancer). Contacts: physiology, and the possibility of influenc- of intestinal anastomoses, as well as the in- The participation in international dermatological or- Faculty of Medicine Charles University ing tissue perfusion under various patho- fluence of anesthetic methods on organ per- ganizations (EADV, EDF AAD) allows us to be involved in Hradec Králové Faculty of Medicine physiological conditions, particularly in fusion and postoperative outcome. in multinational cooperation. The phototherapy section Department of in Hradec Králové perioperative medicine and intensive care. of our department is among the best equipped in the An important area of activity is research Czech Republic and provides refresher courses in photo- Dermatology and Department of into cardiopulmonary resuscitation. dermatology. The current focus of photobiology research Venereology Anesthesiology and We have introduced highly standardized is the monitoring of the success of photodynamic therapy Intensive Care Medicine experimental models of sepsis, cardiopulmo- UV 7002 phototherapeutic cabin in treating psoriasis and superficial skin tumors. Sokolská 581 nary resuscitation, and invasive hemody- 500 05 Hradec Králové Sokolská 581 namics. For assessing tissue perfusion, we No to allergies, Tel.: +420 495 836 357 500 05 Hradec Králové use a variety of technologically advanced de- in children, the dermatological side effects E-mail: [email protected] vices and equipment, including Sidestream of immunosuppressants, metabolic syn- Tel.: +420 495 832 147 yes to health! www.lfhk.cuni.cz/ Dark‑Field (SDF) imaging, Laser Doppler drome in psoriasis, the health risk of dermatology E-mail: [email protected] velocimetry and tissue oximetry. Our current In other projects, we deal with food al- Goeckerman´s treatment for psoriasis, and research priorities include application of CCR experimental model lergy in atopic dermatitis and osteoporosis optimizing methotrexate treatment.

30 Based upon Special Section published in Scientific American Czech Edition Charles University Faculty of Medicine in Hradec Králové, www.lfhk.cuni.cz 31 Faculty of Medicine in Hradec Králové Charles University Department of Infectious Diseases Department of Neurology Teaching The Department of Infectious Diseases represents an integral part of the education Necessary for the functioning of the provided by the Faculty of Medicine. The education of medical students at the de- partment is carried out in the form of lectures, seminars and clinical exercises in both human body the Czech and English language programs. Emphasis is put on travel medicine, tropi- The priorities of the department are teaching students in the General Medicine and cal diseases, and highly contagious diseases. The members of the department also Dentistry programs. In 2005, Assoc. Prof. Waberžinek, M.D., Ph.D., and Dagmar Krajíčková, serve as consultants for antibiotic policies and prevention of nosocomial infections. M.D., Ph.D., issued a textbook at Charles University in Prague entitled Basics of General The department is accredited as a teaching facility for postgraduate medical training, Neurology and in 2007 another one entitled Introduction to Specialized Neurology. For i.e. residency training in infectious diseases, which is available for physicians from the medical students both textbooks are primary sources for the study of neurology. surrounding regions. In April 2014, the department was joined by renowned expert Prof. Roman Herzig, “You feel great? Assoc. Prof. Martin Vališ, M.D. , Ph.D. Do not worry, it will pass.“ M.D, Ph.D., FESO. Dagmar Krajíčková, M.D., Ph.D., successfully completed habilitation Head of the Department of Neurology Assoc. Prof. Stanislav Plíšek, M.D., Ph.D. at the 3rd Medical Faculty of Charles University Prague and was appointed associate Head of the Department of Infectious Diseases professor of neurology, effective from July 2014. We have fulfilled the conditions for Medical care obtaining accreditation for postgraduate studies in the field of neurology and the first students began their studies in 2015. Clinic for Sleep Disorders Outpatient and counseling The department provides comprehensive provided in collaboration with the Depart- Also in 2015, the Department of Neurology held postgraduate course for doctors Diagnostics of various types of sleep disorders and service medical care on both an inpatient and outpa- ment of Pulmonology, especially in cases re- biorhythms: from all over the Czech Republic. In August 2015, we organized the ESO Stroke Sum- tient basis (including intensive care) for pa- quiring intensive care or when circumstances • Narcolepsy, hypersomnia Highly specialized counseling is available for patients mer School, which was attended by more than 40 physicians. with neuroinfections, zoonoses, viral forms of hepati- tients with infectious diseases. The depart- do not permit the patient to be transported. • Abnormal movements while sleeping (restless tis, and tropical and parasitic diseases. In addition, the ment currently has 47 beds, 5 of which are Members of the department are also re- leg syndrome, periodic movements of extremi- department has two specialized centers; the AIDS designated for those patients who require in- sponsible for providing demonstrations of ties while sleeping, grinding teeth, etc.) Center provides outpatient care to HIV positive indi- tensive care. Patients with highly communica- special procedures for handling patients sus- Health and sleep • Night epilepsy viduals from both the Hradec Králové and Pardubice ble diseases that require special isolation pected of highly communicable diseases. Since 2011, when the Department of Neu- regions; the Center for Vaccination and Travel • Night headaches Medicine gives advice and offers vaccinations to measures (tuberculosis, influenza etc.) can be rology branched off from the main building of • Parasomnia (night terrors, nightmares, som- those traveling abroad, and also carries out vaccina- placed in two rooms equipped with air filtra- the University Hospital, our research has been nambulism) tions of patients who may be at risk or require special tion systems. Care is provided to patients of focused on headaches, cerebrovascular disease, • Sleep disorders associated with neurological attention. all age groups, from newborns to geriatric pa- demyelinating and extrapyramidal disorders conditions tients. The most frequently treated diseases in- of the nervous system, seizure, dementia, pedi- clude diarrheal diseases, CNS infections, viral atric neurology, and sleep disorders. We suc- forms of hepatitis, respiratory infections, in- ceeded in setting up a network of sites for fections caused by streptococci, Lyme disease EEG at the University Hospital, electromyo- and HIV, and occasionally imported tropical graphy labs, evoked potentials, and polysom- diseases such as malaria. Diagnostics and Practicing transporting a patient with a highly nography and polygraphy. medical care for patients with tuberculosis is contagious infection (Ebola, MERS ...) We are engaged in centralized, specialized neurological care. The center has been in- volved in diagnosing and treating demyeli- Research nating diseases since 1996 and biorhythms since 2004. In 2010, neuromuscular centers Department of Neurology The department has been involved in in- Clostridial colitis, a growing problem in and an interdisciplinary comprehensive Contacts: Contacts: ternational multicenter studies focused on today´s hospitals. The outcome of this study stroke center were established. Since 2012, Charles University antiviral treatments of chronic hepatitis B has led to faster and more specific diagnos- we have had a center for the treatment of Charles University Faculty of Medicine and C, influenza therapy, and studies evalu- ing, including the ribotyping of Clostridium Sleep laboratory spasticity. Faculty of Medicine in Hradec Králové ating the efficacy and safety of new vaccines. difficile. in Hradec Králové The department members actively partici- Research Department of pate in research projects funded by various Department of Infectious Diseases grant agencies. For example, an ongoing We are involved in international multi- award for best monograph. We are also the Neurology project funded by the Agency for Medical center studies aimed at treating demyelinat- recipient of the Prusík national prize in Sokolská 581 Research of the Ministry of Health focuses ing diseases and epilepsy, the international 2013 for our article entitled Periprocedural Sokolská 581 500 05 Hradec Králové on predictive immunological markers in C genetic research of moyamoya disease, and Risk and Long-term Outcome of Intracranial 500 05 Hradec Králové hepatitis patients. A developmental project other projects in the field of neurology. Angioplasty Based on a Single-Center Experi- Tel.: +420 495 832 428 Tel.: +420 495 835 250 at the University Hospital (in collaboration In recent years, the department has re- ence. The Clinic for Sleep Disorders is in- E-mail: [email protected] E-mail: [email protected] with the Institute of Clinical Microbiology) ceived many awards, for example the Na- volved in diagnosing different types of sleep has been very beneficial in addressing tional Psychiatric Prize and the Rector’s disorders and biological rhythms.

32 Based upon Special Section published in Scientific American Czech Edition Charles University Faculty of Medicine in Hradec Králové, www.lfhk.cuni.cz 33 Faculty of Medicine in Hradec Králové Charles University Department of Rehabilitation Department of Ophthalmology How to restore function The Department of Rehabilitation was founded in 1991 and is engaged in teach- To see properly ing and research. It is a teaching, educational, scientific research, methodological, Ophthalmology is one of the fundamental med- and medical institution in the field of medical rehabilitation. We provide teaching for ical fields and a standard part of the curriculum in students of the General Medicine program and the bachelor’s degree programs in the master’s degree programs in General Medicine Physiotherapy and Nursing. Within the specialized study of applied physiotherapy and Dentistry at our faculty. The subject Nursing and occupational therapy we regularly provided clinical training of physiotherapists Care in Ophthalmology, ENT and Dentistry forms and occupational therapists. The Department of Rehabilitation has full accreditation part of the compulsory postgraduate education. from the Czech Ministry of Health for specialized education of physicians in the field Ophthalmology regularly tops student surveys for “True adventures take place in the head.“ of physical medicine and rehabilitation. best instruction at the faculty. In 1995, the depart- “Do it now.” ment began teaching doctoral students in both Assoc. Prof. Eva Vaňásková, M.D., Ph.D. Prof. Naďa Jirásková, M.D., Ph.D. Head of the Department of Rehabilitation full-time and part-time study programs. The De- Head of the Department of Ophthalmology Inpatient rehabilitation department partment of Ophthalmology is among the best in the Czech Republic in terms of both the scope and New possibilities Research The department treats conditions quality of instruction. We currently have 22 doc- Diagnosing diseases of the retina and optic nerve has The department focuses on the use of Bertec force and impairments related to illness, in- toral students. Every year we grant degrees to at been significantly influenced by the introduction of plates, which use the Balance Master software and jury or following surgery, as well as least five doctoral candidates. Ophthalmology has optical coherence tomography. Significant progress in the treatment of diseases of the central area of the system of diagnostics for postural stability and gait, primary conditions of the musculo- We are the only department in the a separate specialized program in education and postural stability and loading symmetry in amputees, country that has been awarded an training and it is a separate branch for clinical med- retina (diabetic macular edema, the wet form of age- skeletal system. In addition to nursing related macular degeneration, and macular edema in and walking-load reduction of the affected extremity EBO diploma. icine. The department is an accredited workplace in patients following joint replacement, postural stabil- care and physiotherapy, we provide a the central retinal closure vein) has been brought ity and gait loading symmetry in patients following full range of occupational therapy, in- for habilitation as well as for the appointment of about by ocular vascular application of blockers of injuries to the lower extremities, verifying the thera- cluding the use of technical aids, to professorships in the field of ophthalmolo- endothelial growth factor (anti-VEGF). Treating glau- coma has been improved by broadening the range of peutic effect of functional robotic gait (Lokomat) in help patients regain self-sufficiency in gy. Since 2013, it is the only site in the amputees with neurological conditions (stroke), For the past three years the antiglaucomatics. Recent years have seen the com- everyday activities. Our department Czech Republic with accreditation from the assessing and treating patients with dysphagia. Department of Ophthalmology plete modernization of the instruments and equipment also employees a psychologist, a social European Commission for Ophthalmology used in the operating theater. has been judged the best in worker, and a speech therapist. Rehabilitation walk using robotics for preparing board certification of EU doc- tors. It is also the only training center where the country by experts in the doctors can acquire a license for work with field of ophthalmology. Outpatient clinic the LenSX femtosecond laser system.

We provide physiotherapy, exercise therapy, and hydrotherapy. We also evaluate functionality poten- Modern methods of treatment tial as it relates to the patient returning to work. The clinic specializes in dynamic splints, lymphotherapy, The priorities of the past decade, led by gery. In addition, the founding of our refrac- and comprehensive care for patients with painful department head Prof. Jirásková, include tive center now provides comprehensive care Vascularization of the cornea, in the clear center optical portion of the artificial conditions of the musculoskeletal system. We also the introduction of phacoemulsification in in the treatment of refractive errors using Evaluating balance cornea Alphacor, with its whitish edge in provide outpatient rehabilitation for children. cataract surgery and implantation of Boston corneal surgery excimer laser and intraocu- the central periphery keratoprosthesis. The department is also the lar operations utilizing a wide spectrum of Contacts: Kinesiological laboratory only public institution in which the LenSx intraocular implants. There is also a center CONTACTS: Charles University femtosecond laser system is available for cat- for the treatment of macular diseases, one of Charles University Faculty of Medicine We perform diagnostics for stability and gait on aract surgery and corneal surgery. In a very the few such places in the country that pro- Faculty of Medicine in Hradec Králové a stabilographic platform. short time the department was also able to vide care for these financially demanding in Hradec Králové implement the practice of vitreoretinal sur- operations. Department of Department of Inpatient section for Supporting research programs Rehabilitation prosthetics Ophthalmology Nezvalova 265 Research activities at the department fo- treatment (both conservative and surgical) of Sokolská 581 500 05 Hradec Králové This section provides comprehensive care for pa- cus on several basic areas, one of which is the congenital and degenerative diseases of the 500 05 Hradec Králové tients with disabilities of the musculoskeletal system, evaluation of results of various techniques for retina and cornea. We have been participat- Tel.: +420 495 512 483 Tel.: +420 495 837 279 especially following limb amputation. We provide cataract surgery and various types of artificial ing for many years in international clinical E-mail: [email protected] training in the use of prosthetic devices. We also treat Rehabilitation walk after amputation lenses. Other areas of interest include corne- studies concerning the treatment of retinal E-mail: [email protected] skin conditions in connection with amputation. of lower extremities al and intraocular refractive surgery and diseases, glaucoma, and refractive surgery.

34 Based upon Special Section published in Scientific American Czech Edition Charles University Faculty of Medicine in Hradec Králové, www.lfhk.cuni.cz 35 Faculty of Medicine in Hradec Králové Charles University Department of Otorhinolaryngology and Head and Neck Surgery The Fingerland Department of Pathology

Teaching with direct broadcast of An indispensable part of medical training operations The subject of pathological anatomy is one of the most extensive in the medical cur- The department provides undergraduate and postgraduate teaching. The depart- riculum. In the early years of the faculty, lectures in pathological anatomy were given ment uses its own modern textbook on otorhinolaryngology which was created in the solely by Professor Fingerland; it had generally been a privilege of heads. Currently, 1980s and 1990s. A current edition of Medicine of the Head and Neck has been pub- there are a total of five pathology courses amounting to a total of 492 teaching hours lished for postgraduate education. We now increasingly use our own teaching methods of lectures and 705 hours of practicals. with the help of modern computing, for example direct broadcasting of operations from In addition to the teaching of its own compulsory subject, the department is in- within the operating theaters for educational purposes. We have created a database of volved in the teaching of several elective interdisciplinary courses, e.g. Clinico-Patho- “The aim of the ENT department: good videos of pathologies and individual operations and we also use interactive whiteboards logical Conferences, Selected Chapters in Endocrinology and Manifestations of Sys- “Trust in God, but keep your powder dry.” and honest medicine.“ in our instruction. The ENT department serves as a center for the postgraduate educa- temic Disorders in the Oral Cavity. Prof. Aleš Ryška, M.D., Ph.D. Prof. Viktor Chrobok, M.D., Ph.D. tion of physicians in the field of otorhinolaryngology. Currently, the department has ac- The classes take place in a modernized auditorium with 120 seats and in a micro- Head of the Fingerland Department of Pathology Head of the Department of Otorhinolaryngology creditation in the fields of otorhinolaryngology, pediatric otorhinolaryngology, and pho- scope lecture room with 36 seats equipped with video-microscopes and monitors. and Head and Neck Surgery niatrics. For the retraining of specialists, the ENT department organizes courses in en- Since 2006, an online digital atlas collection of histopathology specimens has been Recruiting our own doctors donasal surgery. Since 2011, the ENT department has hosted an annual dissection available to students. In the department there is a long tradition of offering course (ear, nose, throat) at the Institute of Anatomy in Brno and holds an interdiscipli- our faculty’s best students positions as student Surgical treatment of sleep nary symposium in Hradec Králové. It also participates in temporal bone surgery in the research assistants following successful completion disorders Czech town of Svitavy and has recently held courses in skin suturing of the head and Finding the final diagnosis of their exams in pathology. Students then undertake a specific research project under mentorship and in this Surgical treatment is built around the coordinated neck. In 1992, the department was granted accreditation for doctoral studies in the field The main objective of the department’s Czech Republic and Slovakia. Our facilities way become acquainted with the environment and action of the Sleep Center, where all the experts from of otorhinolaryngology. Since 2004, we have offered a doctoral degree in surgery. routine workload of the laboratory. The output is their the University Hospital come together to deal with activities includes a description of complex and skilled team of employees (consultants, successful participation in student scientific confer- diagnosing and treating sleep disorders. The ENT diagnostic surgical pathology cases, including medical scientists and laboratory technicians) ences at the university, national, and international department is involved not only in surgical treatment Supporting research programs over the years, intraoperative frozen sections, cytology (both ensure the most accurate biopsy diagnosis. level, often resulting in prizes and awards. Upon gradu- but also with diagnosing sleep disorders. gynecological and non-gynecological), and We use both classic and modern laboratory ating, the new doctors often pursue postgraduate current priorities autopsy diagnostics for all clinical depart- techniques, such as immunohistochemistry, degrees with the aim of achieving full board certifica- Our research has been focused on func- ther research deals with developing func- ments of the University Hospital as well as histochemistry, immunofluorescence, elec- tion in pathology. Phoniatrics, phonosurgery tional rehabilitation and reconstruction of tional endoscopic surgery of the paranasal for the regional hospitals. Our department is tron microscopy, molecular pathology, com- and laryngeal microsurgery the middle ear, intracranial complications, sinuses and thyroid surgery as well. We also an important consultation center, collaborat- puter image analysis, as well as telepathology The emergence of phoniatrics as a specialization took and cancer surgery of the head and neck. We focus on issues dealing with intracranial in- ing closely with a number of hospitals in the and virtual digital microscopy. place in the 1950s. Since then, the range of treatment have published results on our research into flammation complications, functional test- options for voice and speech disorders has further auditory evoked potential testing and elec- ing of hearing and balance, and the histopa- expanded. The ENT department deals not only with conservative treatment (voice rehabilitation) but also tromyography of the laryngeal muscles. Fur- thology of the temporal bone. surgical options for treating voice disorders. Head and neck cancer Immunohistochemical detection of HER2 protein in breast carcinoma cells Contacts: The sub-projects include early diagnosis of Charles University tumors (NBI imaging techniques),studies of Contacts: Faculty of Medicine cancer prognostic markers, the diagnosis of Charles University in Hradec Králové micrometastases and the importance of TNM classification, swallowing rehabilitation, and Microtomy of histological slides from paraffin Immunohistochemical examination – there are Faculty of Medicine Department of modern methods of surgical treatment, in- blocks – every day about 1000 such blocks are over 150 markers available, over 200 slides are in Hradec Králové Laryngeal carcinoma, NBI investigation processed examined daily Otorhinolaryngology cluding endoscopic and laser procedures. The Fingerland and Head and Neck Research Department of Surgery Diagnosis and treatment Pathology of hearing disorders Currently, we cover the entire spectrum trum of immunohistochemical methods, in Sokolská 581 of routine and research methods used in pa- situ hybridization techniques, PCR diag- Sokolská 581 500 05 Hradec Králové We deal with methods for early detection thology – from autopsy diagnosis through nostics as well as next generation sequenc- 500 05 Hradec Králové Tel.: +420 495 833 819 of hearing impairment in neonates, screen- surgical pathology and cytology, including ing. With the introduction of modern tech- Tel.: +420 495 832 611 ing for hearing disorders in preschool and gyneco-cytological screening. Our labora­ nology, the department has begun to carry E-mail: [email protected] E-mail: [email protected] www.lfhk.cuni.cz/orl-eng school-aged children, and new methods for tory uses many modern diagnostic tools and out experiments on tumor cell lines. rehabilitating and treating hearing disor- equipment – electron microscopy, direct and The department has become a reference lab­ www. fingerland.cz ders (auditory implants). Screening for hearing disorders in a newborn indirect immunofluorescence, a wide spec- oratory for the predictive diagnosis of cancer.

36 Based upon Special Section published in Scientific American Czech Edition Charles University Faculty of Medicine in Hradec Králové, www.lfhk.cuni.cz 37 Faculty of Medicine in Hradec Králové Charles University Department of Pediatrics Department of Obstetrics and Gynecology Treating young patients The entire department serves as a training facility for the Charles University Fac- Center with European accreditation ulty of Medicine in Hradec Králové. We provided instruction for students in both the The Department of Obsterics and Gynecology is a perinatal and oncogynecological General Medicine and Dentistry programs as well as for foreign students in the Eng- center which was awarded a four-year accreditation by the European Board and College lish language programs of General Medicine and Dentistry. In addition, there are ex- of Obstetrics and Gynecology (EBCOG) in February 2015. Given that the University Hos- panding options for students of the bachelor’s degree program. We offer year-round pital is the only such large medical facility in Hradec Králové, we provide specialized postgraduate training for physicians specializing in pediatrics and the department health care for the city and the region at large. In 2003, the center underwent a complete also serves as a training facility for the School of Nursing. renovation. The clinic has a simple layout which complements functionality. We current- ly have 86 beds for intensive obstetric care, postoperative intensive care and standard “People, especially the young, should be care. Our clinic provides chemotherapy as well as biological and supportive therapy for curious. Don’t be content with not knowing. “It is better to be worn out than rusted.” Seek to know.” All for the health of children patients with gynecological malignancies. In 2014, the clinic admitted 4,513 patients Assoc. Prof. Jiří Špaček, M.D., Ph.D., IFEPAG and there were 2,429 births (of which 669 were caesarean sections). Head of the Department of Obstetrics and Assoc. Prof. Sylva Skálová, M.D. Gynecology Head of the Department of Pediatrics We provide the highest level of special- the treatment of cystic fibrosis), gastroenter- We also treated 147 patients ized care in cardiology and prenatal cardio- ology (with a focus on Crohn’s disease), aller- suffering from newly detected gy- Outpatient section and logy, nephrology (including renal biopsy), gology (focusing on uncontrolled asthma), necological carcinomas. The clinic Counselling and advice consulting We provide counselling and advice at our outpatient endocrinology (center for growth hormone immunology (focusing on immunodeficien- is currently involved in seven scien- The outpatient section of our department operates tific grants and nine ongoing clini- clinic on the following matters: treatment and a treatment center for preco- cy), rheumatology, hemato-oncology (treat- • High-risk pregnancies regional consulting centers on topics such as allergy, cal studies. In addition to medical endocrinology and diabetology, gastroenterology, immu- cious puberty), including diabetology and in- ment of children with lymphoblastic leuke- • Sterility care and research activities, teach- nology, cardiology, hematology, nephrology, pulmono­ sulin pump therapy, pulmonology (center for mia), and oncological care for children. • Cytology logy, rheumatology, pediatric osteology, high-risk neo- ing is also an important aspect of • Pediatric gynecology nates. In addition, the department provides patients with clinic life. We provide instruction • Oncogynecology the opportunity to be treated by specialists from other for medical students, students in • Urogynecology In the care of professionals • Pelvic pain management departments – rehabilitation, otorhinolaryngology and Midwifery studies, and postgradu- dermatology. • Myomas and endometriosis The department consists of the standard Liberec (in cooperation with the Children´s Our clinic – view from the outside ate students. • Ultrasonography The inpatient section (including the neonate wards (for infants and for older children) Trauma Center there). The neonatal sec- Chemotherapy Day Unit component) annually treats and the Intensive Care and Resuscitation tion of the department provides intensive almost 4,000 children. Unit for critically ill children from the re- and resuscitation care of neonatal patholo- Starting a happy life In the outpatient sections the number of treated children is gions of Hradec Králové, Pardubice, and gies. more than 20,000. Along with the pediatric clinic, our ma- Given the recent increase in the demand ternity hospital is among the network of for acute perinatal care, the delivery room The latest investigative methods, perinatal centers in the Czech Republic that facilities are limited, as well as are the inten- advanced research provide the highest available level of neona- sive care units for neonates. There are four tal care, including care for infants born pre- delivery rooms (two extra), part of which is The department is committed to imple- of in-home care, and on further increasing maturely. Each year in the clinic there are the ICU and operating room for caesarean menting the latest diagnostic and thera- the quality of diagnostics and the treat- over 2,500 births. sections. peutic methods. In recent years, for exam- ment of pathological conditions in new- Delivery room ple, such methods include controlled hypo- borns. Pediatric Clinic – a contemporary look Contacts: thermia in critically ill newborns and even Leading publications, main research directions Contacts: older children, ligation of ductus arteriosus Charles University Charles University Botalli, monitoring brain function in hy- Assoc. Prof. Jiří Špaček, M.D., Ph.D., births, the results of the research team led by Faculty of Medicine Faculty of Medicine poxic neonates, and organizing in-home IFEPAG, has been head of the department Assoc. Prof. Marian Kacerovský, M.D., in Hradec Králové in Hradec Králové artificial ventilation for seriously chroni- since January 2013. The chief of staff is Ivo Ph.D., have been quite significant. cally ill children. Ongoing research activi- Kalousek, M.D., Ph.D. The main profession- We study vulvovaginal discomfort and the Department of Department of ties predominantly deal with premature al focus of the current head is gynecological vaginal environment, while in the field of on- Obstetrics and Pediatrics neonates, chronic non-specific illnesses of oncology. Dr. Špaček is the main author of the cological gynecology ovarian cancer is the Gynecology the gastrointestinal tract in children, and monograph Vulvovaginal Discomfort and Dis- main topic, with a focus on using targeted Sokolská 581 care for pediatric patients at the center for orders of the Vaginal Environment, which was treatment in chemoresistant tumors. The Sokolská 581 500 05 Hradec Králové diabetes. Research interests also focus on award best scientific monograph in 2013 by clinic cooperates with many foreign institu- 500 05 Hradec Králové diagnosing kidney disease, allergic diseas- the Czech Gynecology and Obstetrics Soci- tions in Europe and in the USA. With the in- Tel.: +420 495 832 840 es, and metabolic diseases. In the future, ety. With 75 articles in prestigious interna- troduction of robotic surgery at the Universi- Tel.: +420 495 833 381 E-mail: [email protected] we hope to place greater emphasis on spe- tional journals over a period of 7 years on the ty Hospital, the clinic has now become a cen- E-mail: [email protected] cialized outpatient care, the development Ligation of ductus arteriosus Botalli topic of intraamnial inflammation in preterm ter of such operations.

38 Based upon Special Section published in Scientific American Czech Edition Charles University Faculty of Medicine in Hradec Králové, www.lfhk.cuni.cz 39 Faculty of Medicine in Hradec Králové Charles University Department of Psychiatry Department of Radiology We provide education for With the help of particles and waves all sub-disciplines The field of radiology was accredited in the framework of Charles University in For the Faculty of Medicine, we provide lectures and exams on the topics of psy- 1999. The workplace carries out teaching for the bachelor’s and master’s degree pro- chiatry, psychiatry for students of dentistry, medical psychology, and nursing psychi- grams at the Charles University Faculty of Medicine in Hradec Králové and the Uni- atry, all in Czech as well as in English. In the field of psychiatry there is also a PhD pro- versity of Pardubice and also performs research. In 2007, cooperation with the De- gram, and the clinic has permission to the world of management in this field. It is also partment of Radiology IPVZ in Prague was launched and our department became the involved in specialized education; the workplace is accredited in the disciplines of clinical base. psychiatry, children and adolescent psychiatry, and addictive diseases. Board certifi- “Psychiatry as a fixed part of the scientific cation exams in psychiatry took place in the spring and autumn of 2014. “He who knows should help others.“ medicine.“ (Hans Ledwinka) Prof. Ladislav Hosák, M.D., Ph.D. Prof. Antonín Krajina, M.D., Ph.D. Head of the Department of Psychiatry To restore mental health Head of the Department of Radiology

The clinic has 60 acute care beds and 56 patients who agree to voluntary hospitaliza- The milestones of the new Sanatorium for addictive beds for subsequent care (the sanatorium for tion. In addition to general psychiatric care, millennium addictive diseases in Nechanice). It provides our outpatient clinic provides services for diseases in Nechanice 2001 – the first examination in the Czech Republic of psychiatric emergency and planned care the treatment of affective disorders, for The sanatorium is a separate workplace of the the viability of heart infarction using mag- Department of Psychiatry. It was launched on across the spectrum of mental disorders. child­hood and adolescent psychiatric disor- netic resonance imaging December 2, 1996 in a renovated building of a hospital The sanatorium for addictive diseases in Ne- ders, and for the treatment of alcoholism 2002 – the introduction of percutaneous vertebro- originally built in 1872 with the contribution of the chanice is a separate workplace of the De- and other drug addictions (AT outpatient plasty Harrach family. The sanatorium provides voluntary partment of Psychiatry. Therapeutic care for section). Since the year 2000, the methado- The Department of Interventional and Angio-Radiology performs minimally invasive therapeutic procedures. 2005 – the first sacroplasty in the Czech Republic withdrawal treatment for men and women addicted to men and women addicted to psychoactive ne substitution program for the chronically psychoactive substances and/or pathological gam- 2006 – percutaneous ablative treatment of tumors bling. The sanatorium offers multiple stays so that substances is provided there, including care ill dependent on opioids takes place at the of the liver and kidney patients can strengthen their abstinence. The treat- for those addicted to alcohol and for patho- AT outpatient clinic. Part of the general Diagnostic and treatment 2006 – the hybrid SPECT/low dose CT, a method that ment is covered by insurance. logical gamblers. Treatment in the form of psychiatric outpatient clinic is a counseling allowed the fusion of functional and ana- short-term and medium-term withdrawal of center for the treatment of psychotic disor- We supply a wide and comprehensive partment is involved in a national program tomical (morphological) images, which improved the diagnostic potential of the treatment (5 - 14 weeks) is offered only to ders and a clinic for sleep disorders. range of radiodiagnostic and intervention researching the early stages of breast cancer. examination and provided synergistic effects procedures, and thanks to interdiscipli- The interventional–radiological workplace of both imaging methods. nary collaboration we even participate in focuses on minimally invasive investiga- 2009 – installation of PET/CT for the diagnostic and Center for sleep disorders and biorhythms other diagnostic and intervention methods tions and therapeutic procedures which use evaluation of the effect on treating malignant (such as PET/ CT, radioablation, verte- special devices and materials (needles, tumor diseases. The Department of Psychiatry (together nambulism), other sleep disorders of biolo- broplastics, etc). The professional staff is catheters, braces, spirals, tissue adhesives, with three other departments) is involved in gical rhythms, and psychological complica- responsible for the appropriate implemen- drugs) introduced by means of percutane- Sanatorium for addictive diseases in the activities of the center for sleep disor- tions of disorders of breathing in sleep. In tation of the imaging examination and the ous injection into the target organs under Nechanice ders. It diagnoses a variety of sleep disorders addition to standard and special examina- correct interpretation of the obtained find- the direct visual control of imaging meth- Contacts: and biological rhythms: insomnia, hyper- tions, it carries out somnological examina- ings. Every year, tens of thousands of pro- ods. In addition to routine procedures (such somnia, narcolepsy, sleep disorders associ- tion and actigraphy (examination of biolo- cedures are carried out using X-ray instru- as sampling of tissue, drainage of purulent Charles University The CT device is a part of the trauma center. ated with physical or mental illness, disor- gical rhythms). Appropriate treatment is ments (imaging, fluoroscopy), ultrasounds, deposits and biliary tract, clearing the ar- Faculty of Medicine ders of the rhythm of sleep and wakefulness, then selected according to the result of the computer tomography devices (CT), mag- teries and veins), we also perform highly Contacts: in Hradec Králové parasomnia (night terrors, nightmare, som- examination. netic resonance imaging (MRI), and angi- specialized treatment of hemorrhagic aneu- Charles University ography catheters in a wide spectrum of rysms in cerebral arteries, portal hyperten- Department of Faculty of Medicine So that medicine does no harm indications. sion, injuries to the thoracic aorta, fractures in Hradec Králové Psychiatry The mammography section of the de- of vertebral bodies in osteoporosis, etc. One of the current priorities of the depart- with hematological and cardiometabolic side Department of Sokolská 581 ment is the research program ANTRE (led effects of antipsychotics in the treatment of Fundamental research programs Radiology 500 05 Hradec Králové by Assoc. Prof. Masopust). The research deals psychotic disorders. Tel.: +420 495 833 184 In the present research, the department research programs at the Department of Sokolská 581 E-mail: [email protected] Can we uncover the causes of schizophrenia? focuses on the diagnosis and classification of Nuclear Medicine are radionuclide imaging 500 05 Hradec Králové emphysema, diagnostics and endovascular and treatment of malignant tumors. Nucle- www.fnhk.cz/psych/ On the initiative of Professor Hosák, the the department and serves as a viable way of treatment of acute vascular strokes, diseases ar cardiology, nuclear neurology, and nucle- Tel.: +420 495 832 292 akademicka-cinnost research of endophenotypes in schizophre- gradually revealing the causes of this major of the aorta, and endovascular treatment of ar endocrinology have been added to these E-mail: [email protected] nia and their genetic substrate takes place at mental illness. portal hypertension. Among fundamental programs in recent years.

40 Based upon Special Section published in Scientific American Czech Edition Charles University Faculty of Medicine in Hradec Králové, www.lfhk.cuni.cz 41 Faculty of Medicine in Hradec Králové Charles University Department of Oncology and Radiotherapy Department of Dentistry Fighting cancer The department provides basic courses on oncology and radiotherapy and an op- All for a healthy mouth tional subject of oncological care in the master´s degree program. Our department is The Department of Dentistry is concerned with the diagnosis and treatment of a wide accredited for specialized education in the field of clinical oncology and radiation on- spectrum of dental and oral diseases and disorders. The department consists of ten divi- cology. In 2005, the lecture notes General Oncology (Karolinum, Prague) were pub- sions and counseling centers for both outpatients and hospitalized care. lished. Learning materials for the specialized program are continuously updated in The Department of Dentistry provides both undergraduate education of dental stu- the form of e-learning. In 2006, doctoral program accreditation was obtained. So far, dents and postgraduate courses and training for dental practitioners and specialists as 12 students in total have successfully participated. well. The department also organizes certificate courses and scientific symposia. The most widely known is Sazama´s Day, an annual conference which for more than 20 years “Salus aegroti suprema lex est.” has been providing both dental practitioners and students with up-to-date knowledge “A bove maiori discit arare minor.” and practical information. Prof. Jiří Petera, M.D., Ph.D. In the new and newly Assoc. Prof. Radovan Slezák, M.D., Ph.D. Head of the Department of Oncology and Head of the Department of Dentistry Radiotherapy In 1997, construction of a new oncology Applying the best current knowledge with a view Dental implants pavilion was completed and three depart- National Oncological Register We provide treatment for all types of dental defects, ments moved into the new location: the De- Part of the department consists of the National towards innovation including edentulous jaws. Such forms of treatment Oncological Register (NOR), which is managed by the partment of Oncology and Radiotherapy, combine the use of dental implants with various types National Health Information System (NHIS). This regis- Department of Clinical Hematology and the At present, there are several basic research disorders, a recent “hot” topic of great con- of crowns, fixed bridges, and removable prostheses. ter is intended mainly for records and monitoring of The Implant Center at the Department of Dentistry is Department of Nuclear Medicine. Simulta- Building of the Department of Oncology and projects being carried out at the Department cern to a majority of dentists, are being stud- patients with serious diseases. It is used for diagnosis unique among its kind in the Czech Republic. neously, the instrumentation and equipment Radiotherapy of Dentistry. For many years A. Šimůnek has ied by Z. Šustová and M. Kapitán and their and treatment, and monitors the development, causes and consequences of disease throughout Europe, par- for radiotherapy was completely updated, and led a research team focusing on implant den- co-workers. R. Koberová Ivančaková deals ticularly malignancies. Data collection in this registry the department is now equipped with 2 lin- clinic for outpatient chemotherapy was built. tistry. Dental pulp stem cells are the research with modern methods of caries prevention Oral hygiene in the Czech Republic is mandatory by law and simulta- ear accelerators and a Varian simulator, an Research activities of the department are fo- topic of J. Suchánek and his colleagues. and its epidemiology. Other clinical activities Individuals interested in improving their oral hygiene neously is absolutely necessary for managing the care automatic Gammamed afterloading system cused on advanced technologies of external Chronic stomatitis and oral manifestations of include treatment of periodontal disease, can visit any of our experienced dental hygienists, in whose care the individual´s oral health will be of cancer patients. In the Czech Republic, this collection for brachytherapy, ultrasound hyperthermia, beam radiotherapy, brachytherapy, and im- various systemic diseases are studied by V. prophylaxis, and the diagnosis and therapy of of data for NOR has been taking place for dozens of assessed, including recommending and planning years, thus making the Czech Republic an example for and 2 therapeutic X-ray devices. A modern munotherapy. Radochová and R. Slezák. Musculoskeletal orofacial malignancies. appropriate hygienic procedures, tools, and methods. other European countries. The hygienist will also carry out complete removal of dental calculus, exogenous dental pigmentations, Comprehensive cancer center therapy of inflamed bleeding gums, and regular care for dental implants. In 2008, the clinic became a comprehen- sive oncological center backed by the Czech Orthodontics Society for Oncology and Societies of Radi- The orthodontic division offers sophisticated treatment of nearly all types of dental anomalies and malocclusion ology, Biology, and Physics. In 2008, 2 new of permanent teeth in children and adults. Nowadays, Varian linear accelerators and a Siemens So- fixed orthodontic appliances, which are more patient matom Sensation CT simulator were in- friendly, are preferred. Brachytherapy of the prostate stalled. This equipment allows image guid- CONTACTS: ed radiotherapy, intensity modulated radio- Contacts: therapy, and four dimensional radiotherapy. Charles University Charles University PET/CT is intensively used for radiothera- Faculty of Medicine py planning. The department can adminis- Faculty of Medicine View of dental implants in edentulous upper jaw Undergraduate students treating a patient during in Hradec Králové ter all forms of systemic antitumor treat- during their surgical insertion. clinical practice. in Hradec Králové ment. In 2009, a centralized location was Department of Oncology established for preparing cytostatics. Linear accelerator Department and Radiotherapy Advances in diagnostics and treatment of Dentistry

Sokolská 581 Getting better treatment Research activities are closely joined with edentulous individuals, both non-invasive Sokolská 581 500 05 Hradec Králové the implementation of new diagnostic pro- and invasive treatment of periodontal diseas- 500 05 Hradec Králové Tel.: +420 495 834 615 Intense research focused on molecular clinical studies, including the EORTC Euro- cedures and modern treatment methods, of es, oral medicine, complex dental care of Tel.: +420 495 832 102 E-mail: [email protected] biology, stem cells, modern techniques of ra- pean studies. In a number of foreign publica- which the most noteworthy are the follow- medically and mentally compromised indi- E-mail: [email protected] diotherapy, and new oncology drugs has been tions it consistently ranks first among clinical ing: oncologic surgery and brachytherapy, viduals, modern preventive activities in pre- www.fnhk.cz/onko/vyuka www.lfhk.cuni.cz/dentistry taking place at the clinic. The clinic is in- workplaces at the University Hospital and orofacial traumatology, dental implants and school and school children, microscopically volved in grant projects and a number of Faculty of Medicine in Hradec Králové. subsequent prosthodontic reconstructions in assisted dentistry, and many others.

42 Based upon Special Section published in Scientific American Czech Edition Charles University Faculty of Medicine in Hradec Králové, www.lfhk.cuni.cz 43 Faculty of Medicine in Hradec Králové Charles University Department of Clinical Microbiology Department of Clinical Biochemistry and Diagnostics

Necessary knowledge of the Teaching and education microscopic world Doctors and other university staff of the Department of Clinical Biochemistry and We teach medical microbiology in the master´s program for students of General Diagnostics participate in undergraduate, graduate and postgraduate teaching for all Medicine and Dentistry and for bachelor‘s degree students in the General Nursing pro- categories of workers in the field of clinical biochemistry. They teach at the Charles gram. We emphasize the practical aspects of the field, i.e. the possibilities of microbi- University Faculty of Medicine in Hradec Králové, Faculty of Pharmacy and even at the ological diagnostics and its indications, the evaluation and interpretation of the clinical Secondary School of Health Sciences in Hradec Králové. significance of microbiological findings, the evaluation of antibiograms and indications Postgraduate teaching involves the training of graduate students in the framework of antibiotics in relation to antibiotic resistance. Students learn the basic techniques of of the doctoral studies in clinical biochemistry as well as pre-board certification train- microbiological diagnosis – microscopy, culturing, and serology in clinical teaching. ing of doctors, other university-educated workers, and laboratory technicians. We co- “If you want to make God laugh, Ladislava Pavlíková, M.D. tell him your plans.” Students of general medicine can deepen their knowledge in the optional Clinical Mi- operate in this area with the Department of Clinical Biochemistry. Head of the Department of Clinical Biochemistry Assoc. Prof. Helena Žemličková, M.D., Ph.D. crobiology course, which investigates in detail the We also organize a number of professional educational events and actively partici- and Diagnostics Head of the Department of Clinical Microbiology topics of the rational use of antibiotics, antibiotic re- pate in seminars, conferences, and congresses at the regional and national level. sistance and infections associated with health care. The National Reference Labo- For foreign students, we offer an optional subject en- Laboratory and outpatient activity Research and cooperation ratory for Cytomegaloviruses titled Microbiological Aspects of Tropical Infectious The staff of the department cooperates on a number of research and teaching projects, such as grants from Diseases. With the advances in technology in the methods, in particular in the field of hemato­ Research activity in the field of diagnostics of human We regularly organize regional scientific work- the CEEPUS agency of healthcare research and pro- cytomegalovirus (CMV) by prof. J. Horáček in 1985 led last decades, the laboratory part of our insti- oncology. In terms of activities carried out, it jects, JHA, or PRVOUK. to the establishment of the National Reference shops on various topics of clinical microbiology for tute has developed significantly and, as a re- is among the largest such workplaces in the A good deal of our research activities are ongoing in Laboratories (NRL) for Cytomegalovirus at the doctors and lab technicians at the University Hospi- sult of a high degree of automation and ro- country. all sections of the laboratory and concern the intro- Teaching Hospital, which in the 1980s and 1990s tal and other medical facilities of Eastern Bohemia. botics in routine analysis, has become an ex- The professional activities of the depart- duction of new methods in the diagnostic and treat- focused on the diagnostics of CMV infections in immu- The ATB center annually takes part in the European tensive workplace of separation techniques ment are ensured by qualified experts who ment processes. nosuppressed patients, in particular after kidney Antibiotic Awareness Day, a campaign to promote re- transplantation. European Antibiotic Awareness Day, (chromatography, electroseparation meth- bring with them strong, international repu- The main objective of the work of the NRL for CMV, sponsible use of antibiotics. 2014, ECDC Stockholm ods), an immunochemical workplace, a tations and place our institute at the fore- led since 2003 by Dr. Štěpánová, is quality assess- workplace of clinical pharmacology, and one front of departments and institutes at the ment of the laboratory diagnostics of CMV in the of clinical and forensic toxicology. medical faculty and University Hospital. Czech Republic. Revealing microscopic pests In the 1990s, a molecular biology divi- The outpatient part of the workplace Concerning diagnostic care, our institute selected special diagnostics of infectious sion was created to carry out investigations takes care of patients with metabolic lipid provides comprehensive services in the field complications of ICU patients, patients in into the human and non-human genome. disorders and nephrolithiasis and, first and of medical microbiology (bacteriology, viro­ immunosupression, patients with infections This section works in union with other in- foremost, patients suffering from metabolic logy, mycology, parasitology) and at the of the bloodstream, the CNS, bones, joints, stitutions at the University Hospital. diseases of the musculoskeletal system. It same time functions as an independent an- and mycobacterial infections. A major acti­ It even collaborates with clinical work- provides highly specialized care for pa- tibiotic center and national reference labora- vity of our laboratories is microbiological places to help introduce new diagnostic tients. tory for cytomegaloviruses. In cooperation control of the hospital environment, sterility Laboratory Cytomegalovirus – isolation from urine with the Clinic of Biochemistry and Diag- of equipment, cells, and tissues used for treat- Biobank – the project BBMRI Seventh day of cytopathic effect on cell cul- nostics, molecular-biological diagnostics is ment. The antibiotic center systematically ture of human embryonic fibroblasts provided mainly in the fields of virology, my- monitors antibiotic resistance and is involved The bank of clinical samples (BBMRI) is veloped methodology. If samples are sub- Contacts: cology, and mycobacteriology. Staff at the in the European Antimicrobial Resistance part of the European project (OP VaVpI jected to genetic testing, it will be exclusive- Charles University CONTACTS: Laboratory of Bacteriology and Mycology, Surveillance Network (EARS-Net, ECDC, RECAMO) for long-term retention of bio- ly for examining genes associated with tu- Charles University in addition to routine diagnostics, deal with Stockholm). logical material of cancer patients with the mor initiation and to the response of such Faculty of Medicine Faculty of Medicine intention of research and development in genes to antitumor treatment. in Hradec Králové in Hradec Králové Examining the effectiveness of new substances the hope of finding new methods of preven- tion, diagnosis and healing. Department of Clinical Department of Clinical Currently, our research focuses mainly Těchonín on the topic of laboratory diagnos- Archiving is done anonymously. All the Biochemistry Microbiology on the area of the mycology and pharmaco­ tics of dangerous infections. In cooperation identification of samples is removed and in- and Diagnostics logy. In cooperation with the Faculty of with the staff of the 2nd Internal Clinic of dicated with an anonymous code. The sam- Sokolská 581 Pharmacy, we research and evaluate the the Teaching Hospital, we have been en- ples are subsequently processed and are Sokolská 581 500 05 Hradec Králové antimicrobial effect of newly synthesized gaged for several years in research into stored in the bank, and will only be used for 500 05 Hradec Králové substances. Also significant is our coopera- intestinal bacterial microflora in idiopathic cancer research. Tel.: +420 495 833 132 Tel.: +420 495 832 129 tion with the Faculty of Military Health at inflammation and colorectal neoplasia and We isolate from them not only the nucle- E-mail: [email protected] E-mail: [email protected] the University of Defense. In addition, we Helicobacter pylori infection in experimental ic acids (e.g. DNA), but even the individual The location of the Department of Clinical cooperate with the scientific workplace in models. cells and proteins according to the newly de- Biochemistry and Diagnostics

44 Based upon Special Section published in Scientific American Czech Edition Charles University Faculty of Medicine in Hradec Králové, www.lfhk.cuni.cz 45 Faculty of Medicine in Hradec Králové Charles University Department of Clinical Immunology and Allergology Department of Forensic Medicine To teach the body’s defense system We provide the teaching of immunology in the context of both the Czech language Teaching in the third millennium and English language master‘s degree program in General Medicine and in Dentistry The Department of Forensic Medicine provides undergraduate teaching of forensic at the Charles University Faculty of Medicine in Hradec Králové. We are accredited medicine for 5th year students (including foreign students) in the programs of General for doctoral study in medical immunology, habilitation, and nomination proceedings Medicine and Dentistry at the Charles University Faculty of Medicine in Hradec Králové. for professorship candidates. Our department is a training center for doctors serving Moreover, the workplace functions as a sub-department of the Department of Forensic in allergology and clinical immunology. We have also implemented internships in clin- Medicine at the Institute for Postgraduate Medical Education in Prague, which is re- ical laboratories and internships in biomedical study programs at the Charles Univer- sponsible for continuous professional training in the field. sity Faculty of Pharmacy and the University of Pardubice. Beside the teaching activities, we also focus on scientific and publication activities. “Immunity is the integrating component of the The doctors at the department specialize mainly in the issue of asphyxia, gunshot inju- “Education without values, as useful as it is, body. Immunology integrates biomedicine.“ ries, death as the result of extreme physical strain, and the use of modern optical and seems rather to make a more clever devil.“ Prof. Jan Krejsek, M.Sc., Ph.D. Clinical and laboratory imaging methods in post-mortem. Our C. S. Lewis Head of the Department of Clinical Immunology most important recent publication is a Assoc. Prof. Petr Hejna, M.D., Ph.D., M.B.A. and Allergology diagnostics of immune scientific monograph entitled Gunshot Head of the Department of Forensic Medicine Grant projects disorders Injuries (2010). It was written by Miro- slav Šafr, M.D., and Associate Professor Research Our grant projects deal with the following: the relation- Petr Hejna. The book won two presti­ The doctors at our institute cooperate with a number ship between the number of bacteria in amniotic fluid We provide diagnostic and therapeutic of domestic and foreign forensic and medical work- gious awards: the Fingerland Prize for and the intensity of the intra-amnial inflammatory care to patients with allergic diseases and dis- places. Research tasks in recent years have focused response in female patients undergoing early amniotic orders of the immune system. We apply func- the best publication in the morphologi- mainly on the issue of forensic and medical phenome- fluid drainage. cal disciplines and the Czech Society of nology of suicide behavior, firearms, morphological tional diagnostics for this purpose. In our Flow cytometry is irreplaceable in the diagnos- Grant projects with external tics of immune system disorders and in scientific Forensic Medicine and Forensic Toxico­ findings in asphyxia, autoptic and biochemical diagnos- clinical lab we have at our disposal all labora- The pavilion of the institute cooperation applications. logy award for the best monograph. In tics of hypothermia in organisms, photogrammetry, optical scanning and the use of advanced imaging 2011, we participated in the release of a monography entitled Blunt Injuries in Forensic We also cooperate with other institutes and depart- methods in forensic and medical diagnostics. ments on the following topics: predicting the response tory procedures necessary for the diagnostic Medicine. In 2012, the doctors of the institute compiled a multimedia teaching aid to therapy in patients with ovarian cancer, predictive decision of doctors of all disciplines. The main atlas for forensic medicine. It is a web application containing over one thousand color immunological markers in patients with hepatitis C, photos and twelve short teaching films. Between 2010 and 2014, we published over comprehensive evaluation of the influence of the technology is multicolor flow cytometry and microenvironment on the clinical course of chronic various immunochemical methods, mainly one hundred entries in professional journals, of which more than fifty were published lymphocytic leukemia. ELISA, immunofluorescence, immunoblot, in foreign journals with impact factor. and the newly introduced Luminex techno­ Application of immunoglobulin saves the lives of logy. We cultivate and analyze cell cultures for In the service of justice pert activities for the Czech police and other patients with immune system disorders diagnostic and research purposes. authorities active in criminal proceedings The Department of Forensic Medicine in (general inspection of security forces, courts, Hradec Králové ensures medicolegal service the state prosecutor's office). The department All about inflammation 3D laser scanning and virtual modelling of for the Hradec Králové region. We carry out also provides continuous consulting activi- the skull for the purpose of individual Examples of the outputs of multicolored The Department of Clinical Immunolo- autopsies in accordance with Czech law, ties, and our experts even accompany police identification and diagnosing traumatic flow cytometry gy and Allergology at the Charles Univer- including post-mortem examinations or- on official investigations of crime scenes and changes sity Faculty of Medicine and University dered by law enforcement authorities in other circumstances under which medico­ Contacts: Contacts: Hospital has from the very beginning been criminal proceedings. The doctors at our de- legal services are requested. Charles University Charles University as an academic workplace focused on re- partment provide consulting and conciliar Our department, along with the Depart- Faculty of Medicine search. Research programs have been im- activities for health care facilities in the Hra- ment of Clinical Biochemistry, is responsi- Faculty of Medicine in Hradec Králové plemented that investigate autoimmune and Immunofluorescence demonstration of antibod- dec Králové region, or professional and ex- ble for the sampling of biological material at in Hradec Králové injurious inflammation. Particular attention ies is irreplaceable in the diagnostics of immuno- autopsies and examining it for the presence pathological diseases. Department of Clinical is paid to allergic inflammation. We study of alcohol and other toxic substances (this Department of Forensic Immunology and the dynamics of inflammatory response fol- have already been published. We are also in- analytical service is provided by the partner Medicine Allergology lowing cardiac surgery in cooperation with volved in research concerning topics from a institute in the framework of the concept of the Department of Cardiac Surgery and variety of clinics at the University Hospital. a “common workplace”). In addition to his- Sokolská 581 Sokolská 581 with the University Hospital. For example, we are involved in the long tological technology, our laboratories are 500 05 Hradec Králové 500 05 Hradec Králové Together with experts from the Depart- term research projects that investigate im- also engaged in serological and immuno­ Tel.: +420 495 836 804 ment of Obstetrics and Gynecology, we have munity affected by aphaeretic procedures in serological examinations of biological mate- Tel.: +420 495 833 454 E-mail: [email protected] looked into the proportion of inflammation hemato‑oncology, injurious inflammation rial (for example, identification of biological E-mail: [email protected] on the pathogenesis of premature rupture of in rheumatology, gastroenterology, dentist- Virtual autopsy: scanning room for post-mortem material, revealing the species classification, www.uslhk.cz the fetal membranes. Our initial findings ry, dermatology and infectious medicine. computed tomography (CT). determining the blood groups, etc).

46 Based upon Special Section published in Scientific American Czech Edition Charles University Faculty of Medicine in Hradec Králové, www.lfhk.cuni.cz 47 Faculty of Medicine in Hradec Králové Charles University Radioisotope Laboratories and Vivarium Department of Physical Education Animals necessary for research Radioisotope laboratories and a vivarium are used for medical research by staff A sound mind in a sound body and postgraduate students at the Faculty of Medicine and in the University Hospi- The aim of the regular semester teaching is to maintain or improve the physical tal Hradec Králové. We also cooperate with the workplaces of the Faculty of Phar- condition of the students and to help balance out the mental demands of studying macy and the Faculty of Military Health, and even with the private sector. We per- medicine. We try to cultivate a lasting habit of an active lifestyle that will remain with form animal experiments for many areas of medical research: tumor growth influ- the students even after they have finished their studies. In addition to the normal team enced by newly synthesized agents, ex vivo and in vivo, the effect of new drugs on sports (volleyball, basketball, football), we also teach individual sports (tennis, squash, the cardiotoxicity of cytostatic agents, changes in liver metabolism and how these spinning, canoeing, yoga, body form, table tennis, aerobics, dance aerobics, Zumba, changes influence liver cirrhosis, fibrosis or hepatocellular damage, improving smartfit, in-line, modern forms of exercise with music, Salsa, Hip-hop, wall climbing, “Man is responsible for everything he has wound healing in diabetic laboratory rats, pharmacokinetic studies of newly syn- fitness training, relaxation exercises, self-defense for women, fighting techniques for “Mens sana in corpore sano.” ever domesticated.“ thesized substances, i.e. potential new drugs, tolerance of extraneous materials to men, bosu, H.E.A.T). The department is a joint department of the Charles University Jindřich Křoustek, M.A. (Antoine de Saint-Exupéry) be used as clinical materials intended for implants, monitoring tissue metabolism Faculty of Medicine in Hradec Králové and the Charles University Faculty of Pharma- Head of the Department of Physical Education Assoc. Prof. Helena Živná, M.D., Ph.D. influenced by different composition of diet or drugs added to compound feed. We cy. We organize summer and winter sports courses. Head of the Radioisotope Laboratories ourselves prepared these special diets at our workplace. A significant part of our Let´s choose and Vivarium experiments monitors the regeneration and repair of neural tissue using stem cells. Students can choose from the following list of activ- Radionuclides: a useful We perform tests on the abnormal toxicity of individual batches of medications dur- ities: badminton, basketball, body form, martial arts research tool ing their production. for men, dance aerobics, fitness - gym, floorball, foot- ball/futsal, H.E.A.T. – Bosu, hip-hop dancing, in-line The utilization of radionuclides in basic medical skating, yoga, canoeing, ice hockey, climbing, swim- research is still prospective. In laboratories, we are ming, pole dancing, power aerobics, Realryder, salsa, able to measure all solution samples containing Decreasing the use of animals self-defence for women, SmartFit, spinning, squash, sources of ionizing radiation, especially beta radia- table tennis, tae bo, tennis, trampolines, volleyball, tion. Animals with experimentally induced pathologi- Zumba. cal conditions are given solutions of substances with The radioisotope laboratories and vivari- incorporated radionuclides and we find their distribu- um are scientific facilities intended especially tion in the organism and observe the metabolic chang- for graduate students whose research topics es. Delivered samples can come from the tissue of focus on experiments on small laboratory animals to which a solution of radionuclides was animals. In undergraduate teaching, we con- given or from tissue culture to which was added a substance with a radionuclide. tinue to decrease the use of research animals in compliance with the global trend. Instead, we have increased our use of teaching movies Tutorial videos of manipulations with labora- and computer programs. tory rats

We breed genetically genetically modified breeding of laboratory Dancers modified animals rats and mice in the vivarium could be un- Work with a device for measuring dertaken. Since 2013, the workplace can In 2009, a group of students from various study years at the faculties of pharmacy and radioactivity in the samples of biological tissues In 2005, the Faculty of Medicine in Hra- breed genetically valuable animals to be medicine came together in Hradec Králové to initiate dancing as a P.E. activity. Each year dec Králové registered in the list of users of used in experiments thanks to our accredi- new members join while older ones leave. Training takes place once a week for an hour and Contacts: genetically modified organisms so that the tation as a breeding institute. a half. Every year we create two choreographies which we then perform at the respective Contacts: Charles University social balls held by the Faculty of Pharmacy and the Faculty of Medicine. It helps demon- Charles University Faculty of Medicine We can perform tests strate what can be accomplished despite the demands of the rigorous study schedule. Faculty of Medicine in Hradec Králové When performing for the first in Hradec Králové instead of you time, the dance group playfully Radioisotope Laboratories named itself “The Hradec Králové Department of Physical and Vivarium We perform animal testing for the less White Coats, Maybe.” On March Education experienced scientists with the help of the 15th, 2014 we took part in the re- Šimkova 870 laboratory staff, and this way tests are per- gional cup competition in Jilemnice Zámostí 683 500 38 Hradec Králové formed in a shorter time and with fewer in Podkrkonoší, which is organized 500 09 Hradec Králové animals. Experiments with laboratory ani- by the Paul Dance Jilemnice profes- Tel.: +420 495 816 133 mals end at our workplace. Transport of the sional dance group. The competition Tel.: +420 495 067 457 E-mail: [email protected] animals out of the building is restricted. Mud bath treatment of induced inflammation hosts many dance groups of various E-mail: [email protected] of the hind feet of laboratory rats backgrounds and ages.

48 Based upon Special Section published in Scientific American Czech Edition Charles University Faculty of Medicine in Hradec Králové, www.lfhk.cuni.cz 49 Faculty of Medicine in Hradec Králové Charles University Department of Information Technology Medical Library

Electronic center for the Faculty of Sources of knowledge Medicine The medical library of the Charles University Faculty of Medicine in Hradec Králové The Department of Information Technology is a specialized institution for the pro- is a specialized library serving vision of services in all areas of information technology for students and staff of the the information needs of pro- Charles University Faculty of Medicine in Hradec Králové. It secures and provides fessionals and students in med- the management and development of the faculty’s network and all the technical ser- icine, nursing and other health vice for IT. It develops and manages the faculty’s web and specialized information sciences. The library offers a systems. The department also manages the information systems and is involved in wide variety of resources, in- “Back up, back up, back up.” their development. Finally, it provides research support to the other workplaces of cluding many databases. It re- “To live effectively is to live with adequate the faculty in the field of mathematical statistics. In addition, the department helps sides in the pleasant “Na Hradě” information.” (Norbert Wiener) Jiří Špulák, M.Sc. Head of the Department of Information Technology prepare the accreditation process and participates in the faculty’s evaluation rating historical building and includes Olga Pitašová, Ph.D. and in scientific meetings. study rooms for students. Addi- Head of the Medical Library tionally, the library runs a study room in the Educational Center Interlibrary loan service The atrium of the building “Na Hradě” at the University Hospital. All for research If any document required for scientific work is not The IT department’s participation in research does among the medical library holdings, the library not consist in independent work, but in the support of arranges interlibrary loan services from other research being done at other departments and work- Quickly, clearly, from anywhere libraries in the Czech Republic or abroad. places. This assistance starts with the planning and proposal of the research project. This includes con- The medical library provides access to sources from any location (e.g. from home, sultations and advice on the precise formulation of electronic information resources, e-books and abroad, other workplaces at the University the goal and purpose of the research, on the definition of concepts and methods for the subject of the study, e-journals. The EZ Proxy system allows staff Hospital). The portal of electronic informa- reference characters, data collection, statistical and students remote access to electronic re- tion resources of the Charles University pro- analysis and the technical processing of data. After vides access to other collecting data, we proceed with statistical analysis databases in all fields of the data, with the graphical and tabular represen- of science. The library tation of results. We then discuss the interpretation of the results. We continuously provide IT service, Modernized classrooms at the faculty, with the latest IT and AV equipment website offers a sam­ workshops and counseling services for the staff of ple of the most im- the faculty and the academic workplaces at the portant medical data- University Hospital. Traditionally among the best bases, the databases of full text journals and In 1964, an ODRA 1003 computer was gion where the Internet was then available. e-books accessible to acquired in the cybernetic room of the then The computers gradually have ceased to be the Faculty of Medi- Department of Medical Physics. It was the the domain of a handful of dedicated indi- cine. first digital computer ever in medical educa- viduals and instead have become an insepa- C o n t a c t s : tion and health care in Czechoslovakia. In rable part of teaching and offer great benefit Charles University 1986, there was a changeover to a series of to faculty staff and students. Contacts: Readers at the library Charles University Faculty of Medicine SM minicomputers, then the only common- ly available minicomputers in the Eastern in Hradec Králové Faculty of Medicine Block. Upon lifting the embargo after the Gathering information in Hradec Králové Department of Velvet revolution there was a major change: the mainframes began to be replaced by per- Medical Library Information Technology sonal computers. The SM 1420 central com- The medical library collects data about the Šimkova 870 puter was replaced by a DEC 5100, which publication activity of the faculty and hospi- Dlouhá ul. 1b 500 38 Hradec Králové took over not only the function of the cen- tal staff. The data is entered into a database 500 01 Hradec Králové tral server to the local computer network of according to guidelines set by the national Tel.: +420 495 816 525 Tel.: +420 495 816 267 the Faculty of Medicine, but began to pro- Research and Development Council. These E-mail: [email protected] E-mail: [email protected] vide services in a project of the node of the guidelines work in accordance with the rules www.lfhk.cuni.cz/ www.lfhk.cuni.cz/it-center CESNET academic Internet network in of the Chancellor´s Office and the internal 1993. Our center of computer technology instructions provided by the leadership of the medical‑library/ was the first institution of its kind in the re- Odra 1204 – “the configuration” of the hardware Faculty of Medicine and University Hospital. Lending department

50 Based upon Special Section published in Scientific American Czech Edition Charles University Faculty of Medicine in Hradec Králové, www.lfhk.cuni.cz 51

Charles University Faculty of Medicine in Hradec Králové

In the World of Modern Medicine Based upon Special Section published in Scientific American Czech Edition LFHK