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Patent Expiration 2001-2015 NCEs—Anti-Infective Drugs Arranged according to the approval year in alphabetical order of generic names. Caspofungin Acetate Ertapenem Sodium Tenofovir Disoproxil Fumarate Adefovir Dipivoxil Micafungin Sodium Nitazoxanide Pazufloxacin Mesylate Prulifloxacin Voriconazole Cancidas® Invanz® Viread® Hepsera® Funguard®/Mycamine® Alinia® Pazucross®/Pasil® Sword® Vfend® O H2N O O NH2 OH O S O- HO • + F NH O Na F O OH OH N O NH2 O HO H O O O N HO O H H N O N OH NH OH N N O O H2N F H N O NH - N N O H2N OH H2N N N O O N O OH N HO O S O O O O N N O N N . + O N N N HN OH Na O P O O O F O NH H N O HO NO2 N N O N HN O S HO NH OH O O O HN S O O O P O N O N H • CH COOH O HO OH O HO N N 3 2 O O H O HO . NH CH SO H OH . O O O N 3 3 OH O O F HOOC COOH O HO Approval Patent Expiration Sales Company Approval Patent Expiration Sales Company Approval Patent Expiration Sales Company Approval Patent Expiration Sales Company Approval Patent Expiration Sales Company Approval Patent Expiration Sales Company Approval Patent Expiration Sales Company Approval Patent Expiration Sales Company Approval Patent Expiration Sales Company 2015/7/26 (US) 2016/5/21 (US) 2018/1/25 (US) 2014/9/2 (US) 2019/3/16 (US) 1993/4/13 (US) 2009/4/13 (US) 2009/2/4 (US) 2016/5/24 (US) 2001 $573 Million 2001 $569 Million 2001 $1,108 Million 2002 $97 Million 2002 N/A 2002 N/A 2002 N/A 2002 N/A 2002 $682 Million 2014/3/9 (EU) 2013/2/2 (EU) 2017/7/25 (EU) 2011/9/10 (EU) 2015/9/29 (EU) No rights (EU) No rights (EU) 2008/10/26 (EU) 2011/1/24 (EU) (US) (Y2015) (US) (Y2015) (US) (Y2015) (US) (Y2015) (JP) (Y2015) (US) (Y2015) (JP) (Y2015) (JP) (Y2015) (US) (Y2015) 2014/3/10 (CN) 2013/2/4 (CN) 2017/7/25 (CN) No rights (CN) 2015/9/29 (CN) No rights (CN) No rights (CN) 2008/11/5 (CN) 2011/2/2 (CN) Profile: Profile: Profile: Profile: Profile: Profile: Profile: Profile: Profile: A lipopeptide antifungal drug acted as glucan synthesis inhibitor A β-lactam antibiotic used to treat moderate to severe bacterial A reverse transcriptase inhibitor used to treat HIV infection and A nucleotide analog reverse transcriptase inhibitor used to treat An inhibitor of the synthesis of fungal cell walls 1,3-beta-D-glucan An antiprotozoal agent used to treat diarrhea caused by Giardia A quinolone antibacterial agent used for the intravenous therapy An inhibitor of bacterial DNA gyrase used to treat urinary tract A triazole antifungal agent used to treat serious, invasive fungal to treat fungal infections. infections. HBV infection. HBV infection. as antifungal drug. lamblia or Cryptosporidium parvum. of several infections. infections. infections. Atazanavir Sulfate Daptomycin Emtricitabine Fosamprenavir Calcium Fosfluconazole Gemifloxacin Mesylate Sertaconazole Nitrate Doripenem Hydrate Eberconazole Nitrate Reyataz® Cubicin® Emtriva® Lexiva®/Telzir® Prodif® Factive® Ertaczo®/Dermofix®/Zalain® Finibax®/Doribax® Ebernet® HOOC O O O - O - NH HN O O HO P OH O O O 2+ . P NH O Ca OH N HN N NH N H N O 2 O F N H H 2 NH2 O l Cl H N N OH C O CONH O O COOH O N N O O 2 O NH N O N N O OH O H H NH S S H H N N S N N N O N N HO O N N N N NH2 N N N O H H O F O N N O O O S O O O F Cl O H COOH HN H2N S NH N Cl H H NH Cl O O O OH OH NH HN N O O O HNO HNO3 O 3 H O N H2SO4 O OH . 2 NH CH3SO3H 2 O F Approval Patent Expiration Sales Company Approval Patent Expiration Sales Company Approval Patent Expiration Sales Company Approval Patent Expiration Sales Company Approval Patent Expiration Sales Company Approval Patent Expiration Sales Company Approval Patent Expiration Sales Company Approval Patent Expiration Sales Company Approval Patent Expiration Sales Company 2017/6/20 (US) 2016/6/15 (US) 2016/3/29 (US) 2017/12/24 (US) 2017/3/25 (US) 2017/4/4 (US) 2014/5/31 (US) 2015/6/5 (US) 2010/4/9 (US) 2003 $1,139 Million 2003 $1,127 Million 2003 N/A 2003 $99.5 Million 2003 N/A 2003 N/A 2003 N/A 2005 N/A 2005 N/A 2017/4/14 (EU) No rights (EU) 2011/1/31 (EU) 2018/3/10 (EU) 2017/1/27 (EU) 2015/6/14 (EU) 2005/2/1 (EU) 2012/8/18 (EU) 2010/4/4 (EU) (US) (Y2015) (US) (Y2015) (US) (Y2015) (US) (Y2015) (JP) (Y2015) (US) (Y2015) (US) (Y2015) (JP) (Y2015) (ES) (Y2015) 2017/4/14 (CN) No rights (CN) 2011/1/31 (CN) 2018/3/9 (CN) 2017/1/27 (CN) 2015/6/15 (CN) No rights (CN) 2012/8/20 (CN) No rights (CN) Profile: Profile: Profile: Profile: Profile: Profile: Profile: Profile: Profile: An antiretroviral drug of the protease inhibitor (PI) class used to A lipopeptide antibiotic used to treat complicated skin infections A nucleoside reverse transcriptase inhibitor (NRTI) used for the A prodrug of amprenavir as a protease inhibitor used to treat HIV A water-soluble phosphate prodrug of fluconazole used to treat A quinolone antibiotic used to treat acute bacterial exacerbation An imidazole class antifungal used to treat skin infections such as A β-lactam class drug used for bacterial infections with ultra-broad An azole antifungal agent used to treat cutaneous fungal treat HIV infection. and staphylococcus aureus bloodstream infections. treatment of HIV infection. infections. fungal infections. of chronic bronchitis and community-acquired pneumonia. athlete's foot. antibiotic spectrum. infections. Entecavir Hydrate Luliconazole Posaconazole Tigecycline Tipranavir Anidulafungin Clevudine Darunavir Ethanolate Telbivudine Baraclude® Lulicon®/Luzu® Noxafil® Tygacil® Aptivus® Eraxis®/Ecalta® Levovir®/Revovir® Prezista® Tyzeka®/Sebivo® O N OH N CF3 H Cl N O HO OH HO O O O H O O H N OH N N N H N NH2 O H H OH N HN O CN H N OH OH O S F OH O H N N O N O O N N H O NH O H O N H2N N N S HO H S HO F N N NH2 O O O NH Cl S N N O O O O O O HN H OH O O OH N OH HO N H2O N OH O OH O O N HO F C2H5OH N H N O OH N HO HO HO Approval Patent Expiration Sales Company Approval Patent Expiration Sales Company Approval Patent Expiration Sales Company Approval Patent Expiration Sales Company Approval Patent Expiration Sales Company Approval Patent Expiration Sales Company Approval Patent Expiration Sales Company Approval Patent Expiration Sales Company Approval Patent Expiration Sales Company 2015/8/21 (US) 2016/7/5 (US) 2019/7/19 (US) 2016/4/9 (US) 2019/12/22 (US) 2020/2/17 (US) 2014/1/28 (US) 2015/2/13 (US) 2023/9/11 (US) 2005 $1,312 Million 2005 N/A 2005 $487 Million 2005 $304 Million 2005 N/A 2006 N/A 2006 N/A 2006 $1,810 Million 2006 N/A 2011/10/18 (EU) 2016/7/5 (EU) 2014/12/20 (EU) 2012/8/21 (EU) 2015/5/4 (EU) 2013/3/18 (EU) 2015/1/30 (EU) 2013/8/24 (EU) No rights (EU) (US) (Y2015) (JPS) (Y2015) (EU) (Y2015) (US) (Y2015) (US) (Y2015) (US) (Y2015) (KR) (Y2015) (US) (Y2015) (CH) (Y2015) 2011/10/18 (CN) 2016/7/5 (CN) 2014/12/20 (CN) 2012/10/3 (CN) 2015/5/4 (CN) 2013/3/18 (CN) 2015/1/30 (CN) No rights (CN) 2023/8/6 (CN) Profile: Profile: Profile: Profile: Profile: Profile: Profile: Profile: Profile: An oral antiviral drug used in the treatment of HBV infection. A topical antifungal imidazole with broad-spectrum used to treat A blocker of the synthesis of ergosterol used as antifungal drug. A glycylcycline antibiotic used to treat gram-positive and - A nonpeptidic protease inhibitor (PI) used to treat HIV infection. An echinocandin antifungal drug used to treat Candidemia and A nucleoside analog as antiviral drug used for the treatment of A protease inhibitor used to treat HIV infection. A synthetic thymidine nucleoside analogue as antiviral drug used cutaneous mycoses. negative bacterial infections. other forms of Candida infections. HBV infection. to treat HBV infection. Maraviroc Raltegravir Potassium Retapamulin Ceftobiprole Medocaril Sodium Etravirine Sitafloxacin Hydrate Levornidazole Ceftaroline Fosamil Acetate Laninamivir Octanoate Hydrate Selzentry®/Celsentri® Isentress® Altabax®/Altargo® Zeftera®/Zevtera® Intelence® Gracevit® 优诺安® Teflaro®/Zinforo® Inavir® CN CN OH O O N O + N N O O O O N K O OH H N N H N - 2 H F N HO N H O F N S OH OH N H O F N N N N S S N P N O OH N O S F H H O N N N l HO O S N H N O C N HO H N N O O N N O HN N N O N O O N NH N - O O 1.5 H O H O O O O l 2 O S S 2 HN NH2 O O C O2N N • CH COOH O O • Br 3 O - + H2N • O NH O Na F H2O NH2 Approval Patent Expiration Sales Company Approval Patent Expiration Sales Company Approval Patent Expiration Sales Company Approval Patent Expiration Sales Company Approval Patent Expiration Sales Company Approval Patent Expiration Sales Company Approval Patent Expiration Sales Company Approval Patent Expiration Sales Company Approval Patent Expiration Sales Company 2021/8/6 (US) 2023/10/3 (US) 2018/10/27 (US) 2017/12/8 (US) 2020/12/13 (US) 2013/12/24 (US) No rights (US) 2018/12/17 (US) 2017/7/17 (US) 2007 $189.7 Million 2007 $1,511 Million 2007 N/A 2008 N/A 2008 N/A 2008 N/A 2009 N/A 2010 N/A 2010 N/A 2021/5/9 (EU) 2022/10/21 (EU) 2018/10/27 (EU) 2017/12/11 (EU) 2019/9/24 (EU) 2009/4/26 (EU) No rights (EU) 2018/12/17 (EU) 2017/7/22 (EU) (US) (Y2015) (US) (Y2015) (US) (Y2015) (CA) (Y2015) (US) (Y2015) (JP) (Y2015) (CN) (Y2015) (US) (Y2015) (JP) (Y2015) 2021/5/9 (CN) 2022/10/21 (CN) 2018/10/27 (CN) 2017/12/18 (CN) 2019/9/24 (CN) 2009/4/27 (CN) No rights (CN) 2018/12/17 (CN) 2017/7/22 (CN) Profile: Profile: Profile: Profile: Profile: Profile: Profile: Profile: Profile: A C-C chemokine receptor-5 (CCR5) antagonist used to treat HIV A HIV-1 integrase inhibitor used to treat HIV infection.
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