Lead Exposure and Behavior: Effects on Antisocial and Risky Behavior Among Children and Adolescents
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Understanding Lead Uptake and Effects Across Species Lines: a Conservation Medicine Based Approach
UNDERSTANDING LEAD UPTAKE AND EFFECTS ACROSS SPECIES LINES: A CONSERVATION MEDICINE BASED APPROACH MARK A. POKRAS AND MICHELLE R. KNEELAND Center for Conservation Medicine, Tufts University Cummings School of Veterinary Medicine, 200 Westboro Rd., North Grafton, MA 01536, USA. E-mail: [email protected] ABSTRACT.—Conservation medicine examines the linkages among the health of people, animals and the environment. Few issues illustrate this approach better than an examination of lead (Pb) toxicity. We briefly review the current state of knowledge on the toxicity of lead and its effects on wildlife, humans, and domestic animals. Lead is cheap and there is a long tradition of its use. But the toxic effects of Pb have also been recognized for centuries. As a result, western societies have greatly reduced many traditional uses of Pb, including many paints, gasoline and solders because of threats to the health of humans and the environment. Legisla- tion in several countries has eliminated the use of lead shot for hunting waterfowl. Despite these advances, a great many Pb products continue to be readily available. Conservationists recognize that hunting, angling and shooting sports deposit thousands of tons of Pb into the environment each year. Because of our concerns for human health and over 100 years of focused research, we know the most about lead poisoning in people. Even today, our knowledge of the long-term sublethal effects of Pb on human health continues to grow dramatically. Our knowledge about lead poisoning in domestic animals is signifi- cantly less. For wild animals, our understanding of lead poisoning is roughly where our knowledge about humans was in the mid-1800s when Tanquerel Des Planches made his famous medical observations (Tan- querel Des Planches 1850). -
Miracle Diets Aren't Fair to Anyone
comment‘ We shouldn’t simply use anecdotes as the basis for changing practice, leaving ‘it to others to find actual evidence NO HOLDS BARRED Margaret McCartney Miracle diets aren't fair to anyone n the world of nutrition, “low carb and key foods or food vouchers. Both and high fat” diets are a growing groups lost weight, marginally more in trend. Big claims are made, the low carb group, but the difference in including from doctors, that these HbA1c between the groups did not reach can “save your life,” “reverse significance. Itype 2 diabetes,” and, of course, help A 2017 systematic review, meanwhile, you lose weight. So, should GPs start found no long term difference between recommending low carbohydrate diets to high and low carb diets in glycaemic people who want to lose weight or who control, weight, or low density have type 2 diabetes? lipoprotein cholesterol. The low carb Criticism of the status quo is diet did, however, allow for more people reasonable. By its nature, diet research to use less medication: the average contains many uncertainties, with few long term improvement was 0.34% lower HbA1c. randomised controlled trials. But doctors, researchers, None of this negates the experience of people who and guideline committees can surely aspire to do better. dedicate themselves to a major dietary change of the low Many in the low carb lobby have been highly critical of carb type and are successful in the long term. It does current government dietary guidance. Some legitimately mean, however, that there isn’t one big, miracle diet fix. -
On Being a Whistleblower: the Needleman Case
ETHICS & BEHAVIOR, 3(1), 73-93 Copyright O 1993, Lawrence Erlbaum Associates, Inc. On Being a Whistleblower: The Needleman Case Claire B. Ernhart Case Western Reserve University Sandra Scarr University of Virginia David F. Geneson Hunton & Williams We believe that members of the scientific community have a primary obligation to promote integrity in research and that this obligation includes a duty to report observations that suggest misconduct to agencies that are empowered to examine and evaluate such evidence. Consonant with this responsibility, we became whistleblowers in the case of Herbert Needleman. His 1979 study (Needleman et al., 1979), on the effects of low-level lead exposure on children, is widely cited and highly influential in the formulation of public policy on lead. The opportunity we had to examine subject selection and data analyses from this study was prematurely halted by efforts to prevent disclosure of our obser- vations. Nevertheless, what we saw left us with serious concerns. We hope that the events here summarized will contribute to revisions of process by which allegations of scientific misconduct are handled and that such revisions will result in less damage to scientists who speak out. Downloaded by [New York University] at 21:22 06 January 2015 Key words: misconduct, misrepresentation, due process, whistleblower The increasing incidence of reports of scientific misconduct is troublesome to the public as well as to the scientific community. Even a few instances of misconduct can erode public trust in science. If we are to sustain the respect of the public when there are allegations of misdeeds, procedures for evaluating evidence must be credible (Teich & Frankel, 1992). -
Environmental Risk Assessment of Chemicals
Society of Environmental Toxicology and Chemistry Technical Issue Paper Environmental Risk Assessment of Chemicals Environmental Risk exposure to a chemical for organisms, such as animals, plants, or microbes, in the environment, which could be Assessment of Chemicals water, soil, or air. Effects can be assessed at different levels of biological organization, which is to say in Environmental risk assessment determines the single cells, individuals, populations, ecosystems, or nature and likelihood of harmful effects occurring landscapes. to organisms such as humans, animals, plants, or microbes, due to their exposure to stressors. A stressor can be a chemical (such as road salt runoff to a lake), Applications of Environmental exotic species (such as a foreign plant), or a change Risk Assessment of Chemicals in physical conditions (such as dredging a channel). Here, we focus on risk assessment of chemicals. The Environmental risk assessments of chemicals can be chemicals can be something that is found in nature, used at many scales. They can take place at the small- such as copper, or something created by humans, such scale site level (such as a release at a manufacturing as pharmaceuticals. Depending on whether humans plant), at the field-scale level (for example, spraying or other organisms or ecosystems are exposed, a plant protection products or pesticides on crops), risk assessment is called either a “human health” or at a regional level (such as a river catchment or an “ecological” risk assessment. Here, the term or bay). Policy makers, including government “environmental risk assessment” is used to include both. agencies, and industries use risk assessments to support environmental management decisions. -
A Toxicology Curriculum for Communities
A Toxicology Curriculum For Communities 43 Module One Introduction to Toxicology 44 Objectives Upon completion of this module, the learner will be able to: Define toxicology and commonly associated terms Differentiate the sub-disciplines of toxicology Describe the classifications of toxic agents Describe the field of toxicology Understand the roles of various agencies Identify potential sources for additional information 45 What is Toxicology? 46 Toxicology Involves all aspects of the adverse effects of chemicals on living systems. 47 General Toxicology Questions 48 What are Harmful or Adverse Effects? Those effects which are damaging to either the survival or normal function of the individual 49 What is Toxicity? The term “toxicity”is used to describe the nature of adverse effects produced and the conditions necessary for their production. Before toxicity can develop, a substance must come into contact with a body surface such as skin, eye or mucosa of the alimentary or respiratory tract. 50 What is Toxic? This term relates to poisonous or deadly effects on the body 51 What is a Toxicant? The term “toxicant” refers to toxic substances that are produced by or are a by- product of human-made activities. 52 What is a Toxin? The term “toxin” refers to toxic substances that are produced naturally. 53 What is a Toxic Symptom? What is a Toxic Effect ? A toxic symptom is any feeling or sign indicating the presence of a poison in the system. Toxic effects refers to the health effects that occur due to exposure to a toxic substance. 54 What is Selective Toxicity? This means that a chemical will produce injury to one kind of living matter without harming another form of life, even though the two may exist close together. -
Lead Poisoning
3 Dec 2003 21:51 AR AR206-ME55-13.tex AR206-ME55-13.sgm LaTeX2e(2002/01/18) P1: GBC 10.1146/annurev.med.55.091902.103653 Annu. Rev. Med. 2004. 55:209–22 doi: 10.1146/annurev.med.55.091902.103653 Copyright c 2004 by Annual Reviews. All rights reserved First published online as a Review in Advance on Aug. 18, 2003 LEAD POISONING Herbert Needleman Professor of Psychiatry and Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213; email: [email protected] ■ Abstract Understanding of lead toxicity has advanced substantially over the past three decades, and focus has shifted from high-dose effects in clinically symptomatic individuals to the consequences of exposure at lower doses that cause no symptoms, particularly in children and fetuses. The availability of more sensitive analytic methods has made it possible to measure lead at much lower concentrations. This advance, along with more refined epidemiological techniques and better outcome measures, has lowered the least observable effect level until it approaches zero. As a consequence, the segment of the population who are diagnosed with exposure to toxic levels has expanded. At the same time, environmental efforts, most importantly the removal of lead from gasoline, have dramatically reduced the amount of lead in the biosphere. The remaining major source of lead is older housing stock. Although the cost of lead paint abatement is measured in billions of dollars, the monetized benefits of such a Herculean task have been shown to far outweigh the costs. INTRODUCTION In recent years, the focus in lead poisoning has shifted away from adults exposed to high doses in industrial settings to the larger population of asymptomatic chil- dren with lesser exposures. -
Herbert Needleman
Special Report on Lead Poisoning in Children Standing Up to the Lead Industry: An Interview with Herbert Needleman INTRODUCTION David Rosner, PhDa,b Gerald Markowitz, PhDa,c Herbert Needleman, MD, is a pioneer in the history of medicine who has helped transform our understanding of the effect of lead on children’s health. In the 1970s, he revolutionized the field by documenting the impact of low lead exposure on the intellec- tual development and behavior of children. In 1979, he published a highly influential study in the New England Journal of Medicine1 that transformed the focus of lead research for the next generation and played a critical role in the elimination of lead in gasoline and the lowering of the CDC’s blood lead standard for children. Building on a study by Byers and Lord in 1943 and those of Julian Chisolm and others in the 1950s and 1960s, which had documented a variety of chronic damage affecting children who showed acute symptoms of lead poisoning, Needleman’s innova- tive study analyzed the lead content of the teeth of schoolchildren, correlating it with the children’s behavior, IQ, and school performance. Not surprisingly, Needleman became the focus of the lead industry’s ire. Beginning in the early 1980s, the industry’s attacks on his research and use of public relations firms and scientific consultants to under- mine his credibility became a classic example of how an industry seeks to shape science and call into question the credibility of those whose research threatens it. Industry consultants demanded that the Environ- mental Protection Agency and, later, the Office of Scientific Integrity at the National Institutes of Health, investigate Needleman’s work. -
Introduction to Environmental Toxicology
Introduction to Toxicology WATER BIOLOGY PHC 6937; Section 4858 Andrew S. Kane, Ph.D. Department of Environmental & Global Health College of Public Health & Health Professions [email protected] ? “The problem with toxicology is not the practicing toxicologists, but chemists who can detect, precisely, toxicologically insignificant amounts of chemicals” Rene Truhaut, University of Paris (1909-1994) Toxicology………… • Is the study of the harmful effects of chemicals and physical agents on living organisms • Examines adverse effects ranging from acute to long-term chronic • Is used to assess the probability of hazards caused by adverse effects • Is used to predict effects on individuals, populations and ecosystems 1 An interdisciplinary field… Clinical Toxicology: Diagnosis and treatment of poisoning; evaluation of methods of detection and intoxication, mechanism of action in humans (human tox, pharmaceutical tox) and animals (veterinary tox). Integrates toxicology, clinical medicine, clinical biochemistry/pharmacology. Environmental Toxicology: Integrates toxicology with sub- disciplines such as ecology, wildlife and aquatic biology, environmental chemistry. Occupational Toxicology: Combines occupational medicine and occupational hygiene. An interdisciplinary field… Descriptive Toxicology: The science of toxicity testing to provide information for safety evaluation and regulatory requirements. Mechanistic Toxicology: Identification and understanding cellular, biochemical & molecular basis by which chemicals exert toxic effects. Regulatory Toxicology: -
An Interview with Herbert Needleman, MD
Can a malpractice insurance company be this protective? In a world where insurance companies often choose settlements instead of aggressive defense, The Doctors Company prides itself on vigorously putting your reputation first. That’s why, when plaintiffs filed over 1,000 breast implant claims against physicians covered by The Doctors Company, none resulted in verdicts against the doctors. Protection both comforting and ferocious—what else would you expect from a medical malpractice insurance company called The Doctors Company? More than 10,000 of your California colleagues already know—we’re a national company with local presence, standing ready to serve you. To learn more, visit us on the Web at www.thedoctors.com or call us at (800) 862-0375. 2 SAN FRANCISCO MEDICINE / JANUARY - FEBRUARY 2006 http://www.sfms.org January / February 2006, Vol. 79, No. 1 Environmental Health and Medicine Feature Articles MEMBER SERVICES 4 On Your Behalf 11 The Mainstreaming of Environmental Medicine and Health Philip R. Lee, MD and Steve Heilig, MPH 43 In Memoriam 43 Calendar of Events 12 Toward an Ecological View: Complex Systems, Health and Disease Ted Schettler, MD, MPH MONTHLY COLUMNS 16 Air Pollution and Heart Disease: Recent Developments Michael Lipsett, MD 7 President’s Message Gordon L. Fung, MD 18 Environmental Contaminants and Human Fertility 9 Editorial Linda C. Giudice, MD, PhD, Alison Carlson and Mary Wade Mike Denney, MD, PhD 20 Standing Up to the Lead Industry: 40 Hospital News An Interview with Herbert Needleman, MD 23 Chemical Exposure and Parkinson’s Disease: A Plethora of Suspects Editorial and Advertising Offices Jackie Hunt Christensen and Deborah Cory-Slechta, PhD 1003 A O’Reilly San Francisco, CA 94129 25 The Real Rx: Slow Food, Lively Places, Real Vitality Phone 415/561-0850, ext. -
State and Local Indoor Air Quality Programs: Five Case Studies
ENVIRONMENTAL LAW INSTITUTE RESEARCH REPORT State and Local Indoor Air Quality Programs: Five Case Studies November 1997 STATE AND LOCAL INDOOR AIR QUALITY PROGRAMS: FIVE CASE STUDIES Environmental Law Institute Copyright © 1997 Acknowledgements This report was prepared by the Environmental Law Institute (ELI) with funding from the U.S. Environmental Protection Agency (EPA) under Assistance Agreement ID No. X-824881-01. It does not represent the views of the EPA and no official endorsement should be inferred. Environmental Law Institute staff contributing to this report were Tobie Bernstein, Maura Carney, Paul Locke, Jay Pendergrass, Vanessa Reeves and Carrie Bader. Mary Becker and Michele Straube also contributed significantly to the report. The assistance of program officials from the states of California, Florida, Minnesota and Vermont, and municipal officials from Montgomery County, Maryland, is gratefully acknowledged. Copyright © 1998 Environmental Law Institute ®. A limited license is hereby granted to visitors to the ELI Web site to download, electronically or mechanically store, or retrieve and print one copy of this work in its electronic format for personal, academic research, or similar non-commercial use only, provided that notice of copyright ownership appears prominently on the copy. Electronic retransmission of the work without the express consent of the Environmental Law Institute is strictly prohibited. All other rights reserved. State and Local Indoor Air Quality Programs Copyright©, Environmental Law Institute®, 1997. -
Round and Round It Goes: the Epidemiology of Childhood Lead Poisoning, 1950-1990
Round and Round It Goes: The Epidemiology of Childhood Lead Poisoning, 1950-1990 BARBARA BERNEY Boston University { { TT EAD IS TOXIC WHEREVER IT IS FOUND, AND IT I is found everywhere. ” The 1988 report to Congress on lead 1 4 poisoning in children by the Agency for Toxic Substances and Disease Registry (1988) thus neatly summarized the last 25 years of epidemiological (and toxicological) studies of lead. Lead has been a known poison for thousands of years. The ancient Greeks described some of the classical signs and symptoms of lead poi soning: colic, constipation, pallor, and palsy (Lin-fu 1980). Some histor ians suggest that lead acetate used by the Romans to process wine contributed to the fall of the Empire (Mack 1973). Despite its known toxicity, lead use in the United States increased enormously from the in dustrial revolution through the 1970s, especially after World War II. Be tween 1940 and 1977, the annual consumption of lead in the United States almost doubled. In the 1980s, largely as a result of regulation of lead in gasoline, lead use in the United States leveled off and began to decrease. In this article I explore the interaction of epidemiology and social forces in the continuing evolution of knowledge about the effects of low- level lead exposure, the extent of the population’s exposure, and the sources of that exposure. I will concentrate on the effects of lead on the central nervous system (CNS) of children. The Milbank Quarterly, Vol. 71, No. 1, 1993 © 1993 Milbank Memorial Fund 3 4 Barbara Berney In the United States, the problem of lead poisoning and low-level lead exposure has been pursued with some consistency over the last 25 to 30 years. -
Behavioral Toxicology and Environmental Health Science Opportunity and Challenge for Psychology
Behavioral Toxicology and Environmental Health Science Opportunity and Challenge for Psychology Bernard Weiss University of Rochester School of Medicine and Dentistry ABSTRACT: Behavioral toxicology is now established nervous system mechanisms, produce distinct be- as a component of the environmental health sciences. havioral reactions. For example, the main oxidant in Its rise paralleled recognition that the adverse health photochemical smog, ozone, is a deep lung irritant impact of environmental chemicals should be gauged eliciting subjective discomfort. by how people feel and function, not solely by death This unique role for psychology grows out of a or overt damage. Its compass extends across the total new perspective by the environmental health sciences, spectrum of environmental chemicals, including heavy particularly environmental toxicology, and by public metals, solvents, fuels, pesticides, air pollutants, and health leaders. Toxicology, the science of poisons, used even food additives. Psychology can help resolve many to be a discipline ruled by the clear criteria of death critical issues in environmental health science. and tissue pathology. The new issues that emerged from our delayed recognition of environmental haz- ards, however, stimulated new questions about adverse Odious waterways and corrosive smog are such tan- effects on health. Were death or tissue lesions the only gible evidence of pollution that they evoke tangible feasible end points? What about disturbances of func- remedies. But eliminating blatant pollution is no more tion? Isn't it important to discover how people feel than a first step in managing the environment and and perform or to intervene when "behavioral changes protecting human health. Some of the most toxic dangerous to a patient and others can occur before contaminants are also the most elusive.