The Role of ABCG2 in Modulating Responses to Anti-Cancer Photodynamic Therapy
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SAAVTC Protocol
BC Cancer Protocol Summary for Treatment of Recurrent and Refractory Neuroblastoma, Ewing’s Sarcoma, Osteogenic Sarcoma or Rhabdomyosarcoma with Topotecan and Cyclophosphamide Protocol Code SAAVTC Tumour Group Sarcoma Contact Physician Dr. Christine Simmons ELIGIBILITY: . Relapsed/refractory Ewing’s sarcoma, rhabdomyosarcoma, intra-abdominal small round blue cell tumour, or neuroblastoma . ECOG PS 0-2 . Adequate hematologic parameters (ANC greater than or equal to 1.5 x 109/L, and platelets greater than or equal to 100 x 109 /L). Adequate hepatic and renal function EXCLUSIONS: . Creatinine clearance less than 40 mL/min. Use with caution in patients with renal dysfunction. See DOSE MODIFICATIONS for reduction in dose in patients with renal dysfunction. ECOG PS 3-4 TESTS: . Baseline: CBC & diff, platelets, creatinine, BUN, bilirubin, ALT, sodium, potassium, phosphate, albumin, urinalysis (r+m) . Before each treatment cycle (Day 1): o CBC & diff, platelets, creatinine, BUN, bilirubin, ALT, sodium, potassium, phosphate, albumin o Urinalysis (r+m). Notify physician if patient has hematuria. Weekly: CBC & diff, platelets PREMEDICATIONS: . ondansetron 8 mg PO prior to treatment . dexamethasone 8 mg PO/IV prior to treatment . prochlorperazine 10 mg PO prn . LORazepam 1 mg PO prn PREHYDRATION: . Ensure patient has taken at least 500 mL of fluid prior to each day of therapy; if not, prehydrate daily with NS 500 mL over 30 minutes to 1 hour. BC Cancer Protocol Summary SAAVTC Page 1 of 3 Activated: 1 May 2014 Revised: 1 May 2021 (IV bag size, infusion time clarified) Warning: The information contained in these documents are a statement of consensus of BC Cancer professionals regarding their views of currently accepted approaches to treatment. -
The Temperature-Dependent Effectiveness of Platinum-Based
cells Article The Temperature-Dependent Effectiveness of Platinum-Based Drugs Mitomycin-C and 5-FU during Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Colorectal Cancer Cell Lines Roxan F.C.P.A. Helderman 1,2 , Daan R. Löke 2, Jan Verhoeff 3 , Hans M. Rodermond 1, Gregor G.W. van Bochove 1, Menno Boon 1, Sanne van Kesteren 1, Juan J. Garcia Vallejo 3, H. Petra Kok 2, Pieter J. Tanis 4 , Nicolaas A.P. Franken 1,2 , Johannes Crezee 2 and Arlene L. Oei 1,2,* 1 Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental and Molecular Medicine (CEMM), Amsterdam University Medical Centers (UMC), University of Amsterdam, Cancer Center Amsterdam, P.O. Box 22700, 1100 DE Amsterdam, The Netherlands; [email protected] (R.F.C.P.A.H.); [email protected] (H.M.R.); [email protected] (G.G.W.v.B.); [email protected] (M.B.); [email protected] (S.v.K.); [email protected] (N.A.P.F.) 2 Department of Radiation Oncology, Amsterdam UMC, University of Amsterdam, P.O. Box 22700, 1100 DE Amsterdam, The Netherlands; [email protected] (D.R.L.); [email protected] (H.P.K.); [email protected] (J.C.) 3 Department of Molecular Cell Biology & Immunology, Amsterdam Infection & Immunity Institute and Cancer Center Amsterdam, Amsterdam UMC, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands; j.verhoeff@amsterdamumc.nl (J.V.); [email protected] (J.J.G.V.) 4 Department for Surgery, Amsterdam UMC, University of Amsterdam, Cancer Center Amsterdam, P.O. -
Topotecan, Pegylated Liposomal Doxorubicin Hydrochloride
Topotecan, pegylated liposomal doxorubicin hydrochloride and paclitaxel for second-line or subsequent treatment of advanced ovarian cancer (report contains no commercial in confidence data) Produced by Centre for Reviews and Dissemination, University of York Authors Ms Caroline Main, Research Fellow, Systematic Reviews, Centre for Reviews and Dissemination, University of York, YO10 5DD Ms Laura Ginnelly, Research Fellow, Health Economics, Centre for Health Economics, University of York, YO10 5DD Ms Susan Griffin, Research Fellow, Health Economics, Centre for Health Economics, University of York, YO10 5DD Dr Gill Norman, Research Fellow, Systematic Reviews, Centre for Reviews and Dissemination, University of York, YO10 5DD Mr Marco Barbieri, Research Fellow, Health Economics, The Economic and Health Research Centre, Universitat Pompeu Fabra, Barcelona, Spain Ms Lisa Mather, Information Officer, Centre for Reviews and Dissemination, University of York, YO10 5DD Dr Dan Stark, Senior Lecturer in Oncology and Honorary Consultant in Medical Oncology, Department of Oncology, Bradford Royal Infirmary Mr Stephen Palmer, Senior Research Fellow, Health Economics, Centre for Health Economics, University of York, YO10 5DD Dr Rob Riemsma, Reviews Manager, Systematic Reviews, Centre for Reviews and Dissemination, University of York, YO10 5DD Correspondence to Caroline Main, Centre for Reviews and Dissemination, University of York, YO10 5DD, Tel: (01904) 321055, Fax: (01904) 321041, E-mail: [email protected] Date completed September 2004 Expiry date September 2006 Contributions of authors Caroline Main Lead reviewer responsible for writing the protocol, study selection, data extraction, validity assessment and writing the final report. Laura Ginnelly Involved in the cost-effectiveness section, writing the protocol, study selection, data extraction, development of the economic model and report writing. -
Testicular Cancer Treatment Regimens
Testicular Cancer Treatment Regimens Clinical Trials: The NCCN recommends cancer patient participation in clinical trials as the gold standard for treatment. Cancer therapy selection, dosing, administration, and the management of related adverse events can be a complex process that should be handled by an experienced healthcare team. Clinicians must choose and verify treatment options based on the individual patient; drug dose modifications and supportive care interventions should be administered accordingly. The cancer treatment regimens below may include both U.S. Food and Drug Administration-approved and unapproved indications/regimens. These regimens are only provided to supplement the latest treatment strategies. These Guidelines are a work in progress that may be refined as often as new significant data becomes available. The National Comprehensive Cancer Network Guidelines® are a consensus statement of its authors regarding their views of currently accepted approaches to treatment. Any clinician seeking to apply or consult any NCCN Guidelines® is expected to use independent medical judgment in the context of individual clinical circumstances to determine any patient’s care or treatment. The NCCN makes no warranties of any kind whatsoever regarding their content, use, or application and disclaims any responsibility for their application or use in any way. Note: All recommendations are category 2A unless otherwise indicated. uPrimary Chemotherapy for Germ Cell Tumors1 REGIMEN DOSING Preferred Regimens BEP (Bleomycin + Etoposide + Days 1-5: Cisplatin 20mg/m2 IV over 60 minutes dailya Cisplatin)2,a,b Days 1-5: Etoposide 100mg/m2 IV over 60 minutes daily Days 1,8,15 OR Days 2,9,16: Bleomycin 30 units IV over 10 minutes daily. -
Tandem High-Dose Chemotherapy with Topotecan–Thiotepa–Carboplatin
International Journal of Clinical Oncology (2019) 24:1515–1525 https://doi.org/10.1007/s10147-019-01517-8 ORIGINAL ARTICLE Tandem high‑dose chemotherapy with topotecan–thiotepa–carboplatin and melphalan–etoposide–carboplatin regimens for pediatric high‑risk brain tumors Jung Yoon Choi1,2 · Hyoung Jin Kang1,2 · Kyung Taek Hong1,2 · Che Ry Hong1,2 · Yun Jeong Lee1 · June Dong Park1 · Ji Hoon Phi3 · Seung‑Ki Kim3 · Kyu‑Chang Wang3 · Il Han Kim2,4 · Sung‑Hye Park5 · Young Hun Choi6 · Jung‑Eun Cheon6 · Kyung Duk Park1,2 · Hee Young Shin1,2 Received: 13 December 2018 / Accepted: 20 July 2019 / Published online: 27 July 2019 © Japan Society of Clinical Oncology 2019 Abstract Background High-dose chemotherapy (HDC) and autologous stem-cell transplantation (auto-SCT) are used to improve the survival of children with high-risk brain tumors who have a poor outcome with the standard treatment. This study aims to evaluate the outcome of HDC/auto-SCT with topotecan–thiotepa–carboplatin and melphalan–etoposide–carboplatin (TTC/ MEC) regimens in pediatric brain tumors. Methods We retrospectively analyzed the data of 33 children (median age 6 years) who underwent HDC/auto-SCT (18 tandem and 15 single) with uniform conditioning regimens. Results Eleven patients aged < 3 years at diagnosis were eligible for HDC/auto-SCT to avoid or defer radiotherapy. In addi- tion, nine patients with high-risk medulloblastoma (presence of metastasis and/or postoperative residual tumor ≥ 1.5 cm2), eight with other high-risk brain tumor (six CNS primitive neuroectodermal tumor, one CNS atypical teratoid/rhabdoid tumor, and one pineoblastoma), and fve with relapsed brain tumors were enrolled. -
Cyclophosphamide and Topotecan As First-Line Salvage Therapy in Patients with Relapsed Ewing Sarcoma at a Single Institution
ORIGINAL ARTICLE Cyclophosphamide and Topotecan as First-line Salvage Therapy in Patients With Relapsed Ewing Sarcoma at a Single Institution Rawad Farhat, MD,* Roy Raad, MD,w Nabil J. Khoury, MD,w Julien Feghaly, BS,* Toufic Eid, MD,z Samar Muwakkit, MD,* Miguel Abboud, MD,* Hassan El-Solh, MD,* and Raya Saab, MD* stable disease (SD), with an overall objective response of Summary: The combination of cyclophosphamide and topotecan 35%.7 In a therapeutic window study conducted by the (cyclo/topo) has shown objective responses in relapsed Ewing sar- Children’s Oncology Group in the United States, treatment of coma, but the response duration is not well documented. We patients with Ewing sarcoma with cyclo/topo resulted in PR reviewed characteristics and outcome of 14 patients with Ewing in 21 of 37 patients, accounting for a response rate of 56%, sarcoma, treated uniformly at a single institution and offered cyclo/ 8 topo at first relapse. Six patients (43%) had relapse at distant and 15 more patients had SD. AreviewoftheGerman sites. All patients received first-line salvage therapy with cyclo- experience with this regimen, in patients with Ewing sarcoma phosphamide 250 mg/m2 and topotecan 0.75 mg/m2, daily for 5 days who received cyclo/topo at either first or second relapse, repeated every 21 days. The median number of cycles was 4 (range 1 showed a response rate of 32.6%.9 In that study, one third of to 10). All toxicities were manageable, the most common being the patients were alive at a median follow-up of 14.5 months transient cytopenias. -
BC Cancer Benefit Drug List September 2021
Page 1 of 65 BC Cancer Benefit Drug List September 2021 DEFINITIONS Class I Reimbursed for active cancer or approved treatment or approved indication only. Reimbursed for approved indications only. Completion of the BC Cancer Compassionate Access Program Application (formerly Undesignated Indication Form) is necessary to Restricted Funding (R) provide the appropriate clinical information for each patient. NOTES 1. BC Cancer will reimburse, to the Communities Oncology Network hospital pharmacy, the actual acquisition cost of a Benefit Drug, up to the maximum price as determined by BC Cancer, based on the current brand and contract price. Please contact the OSCAR Hotline at 1-888-355-0355 if more information is required. 2. Not Otherwise Specified (NOS) code only applicable to Class I drugs where indicated. 3. Intrahepatic use of chemotherapy drugs is not reimbursable unless specified. 4. For queries regarding other indications not specified, please contact the BC Cancer Compassionate Access Program Office at 604.877.6000 x 6277 or [email protected] DOSAGE TUMOUR PROTOCOL DRUG APPROVED INDICATIONS CLASS NOTES FORM SITE CODES Therapy for Metastatic Castration-Sensitive Prostate Cancer using abiraterone tablet Genitourinary UGUMCSPABI* R Abiraterone and Prednisone Palliative Therapy for Metastatic Castration Resistant Prostate Cancer abiraterone tablet Genitourinary UGUPABI R Using Abiraterone and prednisone acitretin capsule Lymphoma reversal of early dysplastic and neoplastic stem changes LYNOS I first-line treatment of epidermal -
Arsenic Trioxide As a Radiation Sensitizer for 131I-Metaiodobenzylguanidine Therapy: Results of a Phase II Study
Arsenic Trioxide as a Radiation Sensitizer for 131I-Metaiodobenzylguanidine Therapy: Results of a Phase II Study Shakeel Modak1, Pat Zanzonico2, Jorge A. Carrasquillo3, Brian H. Kushner1, Kim Kramer1, Nai-Kong V. Cheung1, Steven M. Larson3, and Neeta Pandit-Taskar3 1Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York; 2Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York; and 3Molecular Imaging and Therapy Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York sponse rates when compared with historical data with 131I-MIBG Arsenic trioxide has in vitro and in vivo radiosensitizing properties. alone. We hypothesized that arsenic trioxide would enhance the efficacy of Key Words: radiosensitization; neuroblastoma; malignant the targeted radiotherapeutic agent 131I-metaiodobenzylguanidine pheochromocytoma/paraganglioma; MIBG therapy 131 ( I-MIBG) and tested the combination in a phase II clinical trial. J Nucl Med 2016; 57:231–237 Methods: Patients with recurrent or refractory stage 4 neuroblas- DOI: 10.2967/jnumed.115.161752 toma or metastatic paraganglioma/pheochromocytoma (MP) were treated using an institutional review board–approved protocol (Clinicaltrials.gov identifier NCT00107289). The planned treatment was 131I-MIBG (444 or 666 MBq/kg) intravenously on day 1 plus arsenic trioxide (0.15 or 0.25 mg/m2) intravenously on days 6–10 and 13–17. Toxicity was evaluated using National Cancer Institute Common Metaiodobenzylguanidine (MIBG) is a guanethidine analog Toxicity Criteria, version 3.0. Response was assessed by Interna- that is taken up via the noradrenaline transporter by neuroendo- tional Neuroblastoma Response Criteria or (for MP) by changes in crine malignancies arising from sympathetic neuronal precursors 123I-MIBG or PET scans. -
Complications of Intrathecal Chemotherapy in Adults
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Scholarly Commons@Baptist Health South Florida Baptist Health South Florida Scholarly Commons @ Baptist Health South Florida All Publications 2019 Complications of Intrathecal Chemotherapy in Adults: Single-Institution Experience in 109 Consecutive Patients Fernando Vargas Madueno Baptist Health Medical Group; Miami Cancer Institute, [email protected] Follow this and additional works at: https://scholarlycommons.baptisthealth.net/se-all-publications Citation Journal of Oncology (2019) 2019:4047617 This Article -- Open Access is brought to you for free and open access by Scholarly Commons @ Baptist Health South Florida. It has been accepted for inclusion in All Publications by an authorized administrator of Scholarly Commons @ Baptist Health South Florida. For more information, please contact [email protected]. Hindawi Journal of Oncology Volume 2019, Article ID 4047617, 7 pages https://doi.org/10.1155/2019/4047617 Research Article Complications of Intrathecal Chemotherapy in Adults: Single-Institution Experience in 109 Consecutive Patients Diana M. Byrnes ,1 Fernando Vargas,2 Christopher Dermarkarian ,3 Ryan Kahn,3 Deukwoo Kwon,4,5 Judith Hurley,5,6 and Jonathan H. Schatz 5,6 1 Hematology-Oncology Fellowship Program, Department of Medicine, Jackson Memorial Hospital, USA 2Miami Cancer Institute, Baptist Health South Florida, USA 3University of Miami Miller School of Medicine, USA 4Biostatistics and Bioinformatics Core, USA 5Sylvester Comprehensive Cancer Center, USA 6Division of Hematology, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA Correspondence should be addressed to Jonathan H. Schatz; [email protected] Received 11 January 2019; Revised 26 March 2019; Accepted 11 April 2019; Published 2 May 2019 Guest Editor: Riccardo Masetti Copyright © 2019 Diana M. -
Busulfan in Infant to Adult Hematopoietic Cell Transplant Recipients: a Population Pharmacokinetic Model for Initial and Bayesian Dose Personalization
Published OnlineFirst November 11, 2013; DOI: 10.1158/1078-0432.CCR-13-1960 Clinical Cancer Predictive Biomarkers and Personalized Medicine Research Busulfan in Infant to Adult Hematopoietic Cell Transplant Recipients: A Population Pharmacokinetic Model for Initial and Bayesian Dose Personalization Jeannine S. McCune1,3, Meagan J. Bemer1, Jeffrey S. Barrett5, K. Scott Baker2,3,4, Alan S. Gamis6, and Nicholas H.G. Holford7 Abstract Purpose: Personalizing intravenous busulfan doses to a target plasma concentration at steady state (Css) is an essential component of hematopoietic cell transplantation (HCT). We sought to develop a population pharmacokinetic model to predict i.v. busulfan doses over a wide age spectrum (0.1–66 years) that accounts for differences in age and body size. Experimental Design: A population pharmacokinetic model based on normal fat mass and maturation based on postmenstrual age was built from 12,380 busulfan concentration time points obtained after i.v. busulfan administration in 1,610 HCT recipients. Subsequently, simulation results of the initial dose necessary to achieve a target Css with this model were compared with pediatric-only models. Results: A two-compartment model with first-order elimination best fit the data. The population busulfan clearance was 12.4 L/h for an adult male with 62 kg normal fat mass (equivalent to 70 kg total body weight). Busulfan clearance, scaled to body size—specifically normal fat mass, is predicted to be 95% of the adult clearance at 2.5 years postnatal age. With a target Css of 770 ng/mL, a higher proportion of initial doses achieved the therapeutic window with this age- and size-dependent model (72%) compared with dosing recommended by the U.S. -
Stability of Carboplatin and Oxaliplatin in Their Infusion Solutions Is Due to Self-Association
Syracuse University SURFACE Chemistry - Faculty Scholarship College of Arts and Sciences 2011 Stability of Carboplatin and Oxaliplatin in their Infusion Solutions is Due to Self-Association Anthony J. Di Pasqua Syracuse University Deborah J. Kerwood Syracuse University Yi Shi Syracuse University Jerry Goodisman Syracuse University James C. Dabrowiak Syracuse University Follow this and additional works at: https://surface.syr.edu/che Part of the Chemistry Commons Recommended Citation Di Pasqua, Anthony J.; Kerwood, Deborah J.; Shi, Yi; Goodisman, Jerry; and Dabrowiak, James C., "Stability of Carboplatin and Oxaliplatin in their Infusion Solutions is Due to Self-Association" (2011). Chemistry - Faculty Scholarship. 29. https://surface.syr.edu/che/29 This Article is brought to you for free and open access by the College of Arts and Sciences at SURFACE. It has been accepted for inclusion in Chemistry - Faculty Scholarship by an authorized administrator of SURFACE. For more information, please contact [email protected]. View Article Online / Journal Homepage / Table of Contents for this issue Dalton Dynamic Article Links Transactions Cite this: Dalton Trans., 2011, 40, 4821 www.rsc.org/dalton COMMUNICATION Stability of carboplatin and oxaliplatin in their infusion solutions is due to self-association Anthony J. Di Pasqua,† Deborah J. Kerwood, Yi Shi, Jerry Goodisman and James C. Dabrowiak* Received 13th December 2010, Accepted 23rd March 2011 DOI: 10.1039/c0dt01758b Carboplatin and oxaliplatin are commonly used platinum anticancer agents that are sold as ready-to-use aqueous infusion solutions with shelf lives of 2 and 3 years, respectively. The observed rate constants for the hydrolysis of these drugs, however, are too large to account for their long shelf lives. -
Mobilization Topotecan–Filgrastim Combination Is an Effective Regimen
Bone Marrow Transplantation (2001) 28, 563–571 2001 Nature Publishing Group All rights reserved 0268–3369/01 $15.00 www.nature.com/bmt Mobilization Topotecan–filgrastim combination is an effective regimen for mobilizing peripheral blood stem cells E-JA Yeoh1,7, JM Cunningham1,5,GCYee6, D Hunt2, JA Houston1, SL Richardson1, CF Stewart3, PJ Houghton4, LC Bowman1,5 and AJ Gajjar1,5 Departments of 1Hematology-Oncology, 2Biostatistics, 3Pharmaceutical Sciences, 4Molecular Pharmacology, St Jude Children’s Research Hospital, Memphis, TN, USA; 5Department of Pediatrics, College of Medicine, University of Tennessee Health Sciences Center, Memphis, TN, USA; 6Department of Pharmacy Practice, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USA; and 7Department of Pediatrics, National University of Singapore, Singapore Summary: malignancies.1–5 Improvements in supportive care and increasing experience with stem-cell rescue after myeloabl- We compared the efficacy, toxicity, and cost of topote- ative chemotherapy have reduced the morbidity of high- can–filgrastim and filgrastim alone for mobilizing dose chemotherapy, and this reduction in morbidity has peripheral blood stem cells (PBSCs) in 24 consecutive made such treatment applicable to a wide spectrum of pediatric patients with newly diagnosed medulloblas- diseases.6 Peripheral blood stem cells (PBSCs) are increas- toma. PBSCs were mobilized with an upfront window of ingly used for rescue because of their engraftment charac- topotecan–filgrastim for 11 high-risk patients (residual teristics and the ease with which they can be collected.7,8 tumor у1.5 cm2 after resection; metastases limited to Stem cells are usually mobilized into the peripheral neuraxis) and with filgrastim alone for 13 average-risk blood in one of three ways: with cytokine therapy alone, patients.