Linköping University Post Print Regulation of apoptosis-associated lysosomal membrane permeabilization Ann-Charlotte Johansson, Hanna Appelqvist, Cathrine Nilsson, Katarina Kågedal, Karin Roberg and Karin Öllinger N.B.: When citing this work, cite the original article. The original publication is available at www.springerlink.com: Ann-Charlotte Johansson, Hanna Appelqvist, Cathrine Nilsson, Katarina Kågedal, Karin Roberg and Karin Öllinger, Regulation of apoptosis-associated lysosomal membrane permeabilization, 2010, APOPTOSIS, (15), 5, 527-540. http://dx.doi.org/10.1007/s10495-009-0452-5 Copyright: Springer Science Business Media http://www.springerlink.com/ Postprint available at: Linköping University Electronic Press http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-55061 REGULATION OF APOPTOSIS-ASSOCIATED LYSOSOMAL MEMBRANE PERMEABILIZATION Ann-CharlotteJohansson1, Hanna Appelqvist2, Cathrine Nilsson1,2, Katarina Kågedal2, Karin Roberg1,3, Karin Öllinger2 1 Division of Otorhinolaryngology, Linköping University Hospital, Linköping, Sweden 2 Division of Experimental Pathology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden 3 Division of Otorhinolaryngology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden Correspondence: Ann-Charlotte Johansson, Division of Otorhinolaryngology, Linköping University Hospital, SE-581 85 Linköping, Sweden Phone: +46-13-221525, Fax: +46-13-221529, E-mail:
[email protected] ABSTRACT Lysosomal membrane permeabilization (LMP) occurs in response to a large variety of cell death stimuli causing release of cathepsins from the lysosomal lumen into the cytosol where they participate in apoptosis signaling. In some settings, apoptosis induction is dependent on an early release of cathepsins, while under other circumstances LMP occurs late in the cell death process and contributes to amplification of the death signal.