Ultra-High Resolution Optical Coherence Tomography for Imaging the Anterior Segment of the Eye

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Ultra-High Resolution Optical Coherence Tomography for Imaging the Anterior Segment of the Eye IMAGING ■ R E V I E W ■ Ultra-High Resolution Optical Coherence Tomography for Imaging the Anterior Segment of the Eye Jianhua Wang, MD, PhD; Mohamed Abou Shousha, MD; Victor L. Perez, MD; Carol L. Karp, MD; Sonia H. Yoo, MD; Meixiao Shen, MSc; Lele Cui, MD; Volkan Hurmeric, MD; Chixin Du, MD; Dexi Zhu, PhD; Qi Chen, MD; Ming Li, MD ABSTRACT INTRODUCTION Developments in optical coherence tomography Optical coherence tomography (OCT) is a non- (OCT) have expanded its clinical applications for ul- contact and non-invasive imaging modality based on tra-high resolution imaging of the anterior segment the Michelson interferometer.1,2 It has been widely of the human eye. This review presents the latest ad- used in ophthalmology since its development 20 years vances for imaging the anterior segment of the eye us- ago,1 mainly for imaging the posterior segment of the ing ultra-high resolution OCT (UHR-OCT). Unique eye, including the retina and optic nerve head.3-5 Many applications of UHR-OCT technology in clinical and commercially available OCT instruments have been basic scientific laboratory research are discussed and a extremely helpful in the diagnosis of retinal diseases5,6 summary of the results is provided. The authors fo- and for advancing our capability to research and docu- cused on the use of UHR-OCT for imaging of tear ment structural changes in the retina.7-9 In addition to dynamics, contact lens interactions with the corneal retinal imaging, the retinal OCT10,11 and prototype an- surface, and in vivo histological diagnosis of disorders terior segment OCT instruments2,12,13 were used to ex- of the cornea, as well as the future direction in this plore the anterior segment, mainly the cornea, anterior field. [Ophthalmic Surg Lasers Imaging 2011;42: chamber, and chamber angle.14 In 2005, a commer- S15-S27.] cially available anterior segment OCT (Visante; Carl From Bascom Palmer Eye Institute (JW, MAS, VLP, CLK, SHY, MS, LC, VH, CD, DZ, QC, ML), University of Miami, Miami, Florida; the School of Ophthalmology and Optometry (LC, DZ, QC, ML), Wenzhou Medical College, Wenzhou, Zhejiang, China; and the Department of Ophthalmology (CD), First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. Originally submitted February 11, 2011. Accepted for publication February 25, 2011. Supported in part by grants from Vistakon, Allergan, Bausch & Lomb, CibaVision, CooperVision, and Alcon Research Laboratories, and by research grants from NIH Center Grant P30 EY014801 and Research to Prevent Blindness. The authors have no financial or proprietary interest in the materials presented herein. The authors thank Drs. Eduardo Alfonso and Carmen Puliafito for their support, and Dr. Britt Bromberg of Xenofile Editing for providing editing services for this manuscript. Address correspondence to Jianhua Wang, MD, PhD, Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, 1638 NW 10th Avenue, McKnight Building–Room 202, Miami, FL 33136. E-mail: [email protected] doi: 10.3928/15428877-20110627-02 OPHTHALMIC SURGERY, LASERS & IMAGING · VOL. 42, NO. 4 (SUPPL), 2011 S15 IMAGING IMAGING Zeiss Meditec, Inc., Dublin, CA) was then produced and width with some of the instruments were enough to for anterior segment imaging.15 cover the entire anterior segment.2,14 In this review, we will focus on recent advances for With the recent advances in SD-OCT, which has a imaging the anterior segment of the eye using ultra-high resolution of approximately 5 µm, commercially avail- resolution OCT (UHR-OCT) with resolution below 5 able instruments for retinal scanning could also be used µm. Researchers including our group and companies to scan the anterior segment.31 These included the Cirrus have developed UHR-OCT devices that can image (Carl Zeiss Meditec, Inc.), RTVue (Optovue, Meridian- the anterior segment of the eye in a rapid and patient- ville, AL), Spectralis (Heidelberg Engineering, Dossen- friendly way, with a novel resolution of 1 to 3 µm.16-25 heim, Germany), 3D OCT (Topcon Medical Systems, In this review, we will provide a summary of our results Oakland, NJ), and Bioptigen SD-OCT (Bioptigen Inc., and other published studies using this technology and Research Triangle Park, NC) and others31,42,43 for imaging its unique applications in clinical and basic scientific human eyes. The scan width of approximately 3 to 6 mm laboratory research use. We will discuss how the UHR- for imaging the anterior segment limited some applica- OCT was used for imaging the tear dynamics,20,26,27 tions that demanded a wide scan width, such as imaging contact lens interactions with the corneal surface,26 and the upper and lower tear menisci simultaneously.20 in vivo histological diagnosis of disorders of the cor- The development of UHR-OCT has significantly nea.28 This will also include personal experiences based improved anterior segment imaging capabilities.16-19 on unpublished data using UHR-OCT. Finally, we will In 2001, Drexler et al. reported an image of a normal briefly discuss future directions in this field. human eye using approximately 2-µm axial resolution Although we understand that other published TD-OCT.18 This may be the first demonstration for works have reviewed the use of OCT to study the ante- imaging the Bowman’s layer with UHR-OCT.18 In rior segment, these have mainly covered time-domain 2004, Drexler reported 1-µm axial resolution OCT OCT instruments and high-resolution spectral-domain for imaging the cornea in vitro.17 In 2007, Christo- OCT (SD-OCT).15,29-32 It is important to mention poulos et al. reported the use of corneal UHR-OCT that, simultaneous with the development of UHR- for imaging tear film, corneal epithelium, Descemet OCT for imaging the anterior segment, extended scan membrane, and the endothelium.19 In this report, depth OCT has been developed also for imaging the the trauma with epithelial ingrowth by LASIK has anterior segment, including the anterior chamber and been visualized clearly.19 By using a light source with crystalline lens.33-35 However, the extended scan depth a broad bandwidth of more than 100 nm, ultra-high OCT is not within the scope of this summary. This resolution is achieved with a specifically designed review is focused on the latest clinical applications in spectrometer that detects the fringes collected from anterior segment imaging with UHR-OCT and pro- both reference and sample arms.7,19,20,22-24,26,28,44-47 vides the most recent update in the use of a novel and With a charge-coupled device line scan camera in “futuristic” way to image this part of the eye to add the spectrometer, the speed ranges normally from useful information to the field. 24K to 26K A-scans per second.7,22,23 With a com- plementary metal–oxide–semiconductor line scan UHR-OCT TECHNIQUE camera or ultra-high speed swept source, the speed can be much higher.25,48,49,50 Axial resolution is 2 to The first generation of OCT for imaging the anterior 4 µm in these UHR-OCT instruments.7,20,24,26,28,44-47 segment was the time-domain OCT (TD-OCT). It had Although some instruments have scan widths of ap- approximately 10- to 18-µm resolution and 2K A-scans proximately 5 mm,24 others have wider scan widths per second. The center wavelength was 1,310 nm in the of up to 12 mm.20 Apparently, there are two com- Visante,36 the SL-OCT (Heidelberg Engineering, Heidel- mercially available UHR-OCT devices, including the berg, Germany),37 and other prototypes.38-40 In addition, Bioptigen SD-OCT22,23 and Copernicus HR SOCT modified retinal TD-OCT instruments, such as the Stra- (Optopol Technology SA, Zawiercie, Poland).24 With tus (Carl Zeiss Meditec, Inc.), also were used to image the these commercial and prototype UHR-OCT instru- anterior segment.29,41 With TD-OCT, the speed was low ments, the tear film,20,26 tear meniscus,20 contact and resolution was not very high, although the scan depth lens,20,24,26,45,46 and corneal layers28,51-53 can be im- S16 COPYRIGHT © SLACK INCORPORATED IMAGING IMAGING Figure 1. Ultra-high resolution optical coherence tomography image of the central cornea with a PureVision (Bausch & Lomb, Rochester, NY) lens after instillation of artificial tears. The central cor- nea was imaged with 6-mm scan on the horizontal meridian. The image was taken immediately after lens insertion and instillation of one drop of artifi- cial tears. The epithelium, including the basal cell layer, and Bowman’s layer, are evident in addition to the pre-lens and post-lens tear films. Total cor- neal thickness was measured at 526 µm. Bars = 250 µm. (Reprinted with permission from Wang J, Jiao S, Ruggeri M, Shousha MA, Chen Q. In situ visualization of tears on contact lens using ultra- high resolution optical coherence tomography. Eye & Contact Lens. 2009;2:44-49.) aged, and the axial resolution is sufficient for clear age these is essential to precisely measure the thickness visualization of structures of interest (Fig. 1). Optical of the PLTF and PoLTF. UHR-OCT made it possible distortion of the OCT images needs to be corrected to directly visualize and calculate the tear film as long before the measurement is taken.54 However, we cited as it is thicker than 3 µm.20,26 In a previous study,26 these published and unpublished images, which are dynamic changes of the PLTF and PoLTF after instil- not optically corrected. The image correction has lation of artificial tears were investigated using UHR- been reported in the literature54,55 and the same pro- OCT.
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