Review of Cornea & Contact Lenses

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Review of Cornea & Contact Lenses RCCL OCTOBER 2016 REVIEW OF CORNEA & CONTACT LENSES Lids & Lenses How eyelid disease can compromise contact lens wear, and what to do about it. Supplement to MMWR Alerts • Drug-Eluting Contact Lenses • Refractive Surgery Controversies • Branding 001_RCCL01016_Cover-R4.indd 1 9/29/16 6:28 PM The first contact lens specifically designed for your patients’ digital life and everyday living_ 9 out of 10 digital device users* agreed that Biofinity Energys™ contact lenses made their eyes feel good1. 8 out of 10 digital device users* agreed that Biofinity Energys™ contact lenses made their eyes feel less tired1. Your patients’ busy lives happen on-screen and off. Help them experience the contact lens designed for the way they live. Biofinity Energys™ contact lenses help with eye tiredness and dryness commonly associated with digital device use. Considering 90 percent of U.S. adults use digital devices more than two hours per day2, the opportunity to upgrade your patients is significant. Biofinity Energys™ contact lenses feature a revolutionary Digital Zone Optics™ lens design and Aquaform® Technology. Energize your practice —prescribe the patent-pending contact lens innovation made for today's digital lifestyle. Visit coopervision.com, or talk to your CooperVision® representative for details. Welcome to the new comfort zone_ * Among patients who use digital devices at least 4 hours per day at least 5 days per week and self-report symptoms of eye fatigue at least once per week. 1 After 1 week of wear; data on file. 2 The Vision Council. Eyes overexposed: the digital device dilemma: 2016 digital eye strain report. ©2016 CooperVision 9033O BC 7/16 RCCL0916_Coopervision Biofinity.indd 1 8/29/16 11:01 AM contents Review of Cornea & Contact Lenses | October 2016 departments features Beat the Blepharitis Blues News Review 4 To understand and treat this common lid US Refractive Surgeons Now Ready condition, make sure you’re clear on its to SMILE; Microbiota Protects many diff erent presentations. Against P. aeruginosa Infections By Abby Gillogly Harsch, OD, Nicole 12 Stout, OD, and Nathan Lighthizer, OD 6 My Perspective MMWR and Contact Lens Alerts The Chicken-and-Egg By Joseph P. Shovlin, OD Problem of MGD and Contact Lens Wear Which came fi rst, the dysfunction or the 8 Pharma Science & Practice discomfort? Researchers aren’t sure, 16 but clinicians need to manage them Is a Sustained Medication Delivery simultaneously. System on the Horizon? By Arthur B. Epstein, OD By Elyse L. Chaglasian, OD, and Tammy Than, MS, OD Lids, Friction and 10 Practice Progress Contact Lens Wear Put a Lid on CL Discomfort Does a relatively new phenomenon help explain contact lens discomfort? By Mile Brujic, OD, and Jason R. Miller, OD, MBA By Sruthi Srinivasan, PhD, BSOptom, 20 FAAO 36 The GP Experts Don’t Forget to Check the Lids By Robert Ensley, OD, and CE — How Lid Malposition Heidi Miller, OD Can Compromise Contact Lens Wear 38 Out of the Box Keep these conditions in mind Brand Yourself, and They Will Come 24 to prevent or By Gary Gerber, OD rectify potential obstacles to a successful fi t. By Steven Turpin, MS, and Leonid Skorin Jr., OD, DO, MS How Would You Handle These Refractive Surgery Controversies? Despite the procedure’s popularity, some issues still remain. How should you 30 address them? By Aaron McNulty, OD, and Ian McWherter, OD Become a Fan on Follow Us On Facebook Twitter /ReviewofCorneaAndContactLenses @RCCLmag REVIEW OF CORNEA & CONTACT LENSES | OCTOBER 2016 3 003_1016RCCL_TOC.indd 3 9/29/16 6:31 PM News Review IN BRIEF US Refractive Surgeons Now ■ Conjunctival chemosis may be a mark- er to help clinicians predict Pseudomo- nas aeruginosa as the bacterial agent Ready to SMILE responsible for certain corneal ulcers, new research suggests. A masked review looked at 62 infective corneal ulcers new refractive surgery femtosecond laser—translates into and found 14 of 16 cases of P. aerugino- option, Zeiss’s VisuMax better outcomes, and newer studies sa–related corneal ulcers presented with conjunctival chemosis, compared with small incision lenticule report refractive outcomes superior only six of the remaining 46 cases caused extraction (SMILE) to the 2008-2009 results.4,5 1 A by other organisms. Whether or not che- procedure, recently received FDA The FDA’s approval came on the mosis was present predicted or excluded P. aeruginosa with roughly 87% accuracy, approval. The SMILE procedure in- heels of a study demonstrating posi- the researchers conclude.1 volves the creation of a disc-shaped tive visual acuity and refractive pre- 1. Michael KB, Rotchford A, Ramaesh K. lenticule in the stroma using a fem- dictability outcomes for 336 eyes Conjunctival chemosis as a specifi c feature of Pseudomonas aeruginosa corneal ulcers. Cornea. tosecond laser, which the surgeon treated with the SMILE procedure, 2016;35(9):1182-4. removes through a small incision— according to a Zeiss press release.6 ■ A new study sheds light on the impact obviating both the creation of a fl ap The study found participants had environmental conditions have on tear infl ammatory mediators in contact lens and use of an excimer laser needed stable vision six months post-pro- wearers.1 Fifty-four CL wearers were for LASIK. cedure, and all but one subject had exposed to two environmental condi- “Since there is no fl ap, there are uncorrected visual acuity of 20/40 tions: standard (50% relative humidity) or adverse (5% relative humidity). The no fl ap related issues. There is also or better; 88% had uncorrected researchers analyzed changes in concen- vastly less interruption of nerve visual acuity of 20/20 or better. tration of: epidermal growth factor (EGF); interleukin (IL)-1 receptor antagonist, IL- fi bers so one would anticipate The SMILE procedure is indicat- 1β, IL-2, IL-4, IL-6 and IL-8; tumor necrosis less dry eye,” says John F. Doane, ed for the reduction or elimination factor α; monocyte chemoattractant protein-1; and matrix metalloproteinase MD, of Discover Vision Centers in of myopia of -1.00 D to -8.00D, (MMP)-9. Under standard conditions, EGF Kansas City, MO, a clinical inves- with ≤ -0.50D cylinder and MRSE increased signifi cantly while IL-1β and IL-2 tigator for Zeiss. “The refractive -8.25D in patients at least 22 years decreased signifi cantly. Under adverse conditions, IL-6 increased signifi cantly. results are essentially the same. old with documented stable refrac- During CL wear, secretion of several in- Interestingly, since the surgery is tion over the past year, Zeiss says. fl ammatory mediators varies, depending on the type of CL and the environmental done in a vacuum—i.e., the corneal “If worldwide acceptance fore- conditions at play, the study concludes.1 stroma that is not exposed to the shadows what will occur in the 1. Martín-Montañez V, Enríquez-de-Salamanca A, atmosphere—the procedure is dose United States, we can expect quick López-de la Rosa A, et al. Eff ect of environ- mental conditions on the concentration of tear independent. We are just as predict- uptake of the SMILE procedure,” infl ammatory mediators during contact lens able with a -1D as we are with a Dr. Doane suggests. Over half a wear. Cornea. 2016;35(9):1192-8. -10D, which is unique to all prior million procedures have been per- ■ Researchers recently evaluated the effi cacy and safety of transcutaneous corneal refractive procedures.” formed worldwide, Zeiss says. electrical stimulation for symptoms A recent study examined the fi ve- and clinical signs of dry eye. The study 1. Blum M, Täubig K, Gruhn C, et al. Five-year results year results of the fi rst 56 eyes treat- of small incision lenticule extraction (ReLEx SMILE). included 27 patients with dry eye who Br J Ophthalmol. 2016;100:1192–5. underwent transcutaneous electrostim- ed with SMILE for myopia in 2008- 1 2. Zalentein WN, Tervo TM, Holopainen JM. Sev- ulation, wherein electrodes were placed 2009 using the 200kHz VisuMax. en-year follow-up of LASIK for myopia. J Refract onto the periorbital region of both Researchers found a mean regres- Surg. 2009;25:312–8. eyes in addition to manual stimulation 3. Sekundo W, Bönike K, Mattausch P, et al. Six-year with a hand-piece conductor.1 Results sion of −0.48D over fi ve years, follow-up of laser in situ keratomileusis for moderate showed the Ocular Surface Disease Index and extreme myopia using a fi rst-generation excimer improved from 43.0±19.2 at baseline to which is at least as good as the data laser and microkeratome. J Cataract Refract Surg. 25.3±22.1 at the completion of treatment.1 of other procedures, they noted— 2003;29:1152–8. 4. Ivarsen A, Asp S, Hjortdal J. Safety and complica- These improvements were maintained at the mean regression for LASIK is six- and 12-month follow-up evaluations. tions of more than 1500 small-incision lenticule ex- 0.63D to 0.97D after six to seven traction procedures. Ophthalmology. 2014;121:822–8. As the study suggests it improves dry eye 5. Blum M, Kunert KS, Gille A, et al. LASIK for myopia without adverse eff ects, transcutaneous years.2,3 They conclude SMILE is an using the Zeiss VisuMax femtosecond Laser and MEL electrical stimulation shows potential to effective, stable and safe procedure 80 Excimer Laser. J Refract Surg. 2009;25:350–6. widen the scope of treatment options for 6. Zeiss. Zeiss receives US FDA Approval for dry eye. for myopia and myopic astigmatism VisuMax SMILE vision correction procedure, the 1 latest advancement in laser eye surgery. Press 1. Pedrotti E, Bosello F, Fasolo A, et al.
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