Does Screening for Congenital Cytomegalovirus at Birth Improve
Review Does screening for congenital cytomegalovirus at birth improve longer term hearing outcomes? Cathie Hilditch,1,2 Bianca Liersch,3 Nicola Spurrier,4,5 Emily J Callander,6 Celia Cooper,7 Amy K Keir1,2,8 ► Additional material is ABStract What is already known on this topic? published online only. To view Currently, the diagnosis of congenital cytomegalovirus please visit the journal online (cCMV) infection in most highly resourced countries (http:// dx. doi. org/ 10. 1136/ Congenital cytomegalovirus (cCMV) is the is based on clinical suspicion alone. This means only ► archdischild- 2017- 314404). largest non-genetic cause of sensorineural a small proportion of cCMV infections are diagnosed. 1Healthy Mothers, Babies hearing loss (SNHL) in children. Identification, through either universal or targeted and Children Theme, South cCMV-related SNHL is progressive in more than screening of asymptomatic newborns with cCMV, who ► Australian Health and Medical 50% of cases, and affected infants are likely to Research Institute, North would previously have gone undiagnosed, would allow pass their newborn hearing screen. Adelaide, South Australia, for potential early treatment with antiviral therapy, Australia ongoing audiological surveillance and early intervention 2Robinson Research Institute and the Adelaide Medical if sensorineural hearing loss (SNHL) is identified. This School, University of Adelaide, paper systematically reviews published papers examining North Adelaide, South Australia, the potential benefits of targeted and universal screening What this study adds? Australia 3 for newborn infants with cCMV. We found that the Children’s Audiology Service, ► Identification, through either universal or Women’s and Children’s Health treatment of these infants with antiviral therapy remains Network, North Adelaide, South controversial, and clinical trials are currently underway targeted screening of asymptomatic newborns Australia, Australia to provide further answers.
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