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Guide to Microfluidic & Nanofluidic Solutions Guide to Microfluidic & Nanofluidic Solutions pumps, heaters, chips & connectors www.harvardapparatus.com Table of Contents Micro/Nanofluidics Introduction Why Miniaturization?................................................................................................3 Evolution of Research Reactor Fluidic Devices............................................................4-5 What do we mean by Micro and Nanofluidics? ..........................................................6-7 Applications of Microfluidics ......................................................................................8 Applications of Nanofluidics ......................................................................................9 Let Our Expertise Work for You 108 years of Experience in Low-Flow Science ............................................................10 Harvard Apparatus Micro and Nanofluidics Advantage ................................................11 Harvard Apparatus Family of Companies ..................................................................12 Pump Application Questionnaire ..............................................................................13 Syringe Pumps Nanomite ............................................................................................................14 Pump 11 Pico Plus ................................................................................................14 Pump 22..............................................................................................................14 Pump 33 (Dual Syringe) ........................................................................................14 Microliter Syringe Pump Module ..............................................................................14 NEW PHD ULTRA™ ................................................................................................15 PHD 22/2000 Programmable................................................................................15 PHD 22/2000 with Microliter Syringe Rack..............................................................15 PHD 4400 Hpsi ..................................................................................................15 Multiple Animal Feeding System ..............................................................................15 NEW PHD ULTRA™ ..............................................................................................16-17 Pico Plus Syringe Pump..............................................................................................18 Model 33 Syringe Pump ............................................................................................19 Nanoleader Series of Pumps NLS110P Pressure Pump..................................................................................20-21 PLI-100 Nano Dispenser ......................................................................................22-23 General Accessories Microfluidic Chip Holders and Connection Kits Fluidic Connect 4515........................................................................................24 Fused Silica Connection Kit ................................................................................24 Teflon Connection Kit ........................................................................................24 Stainless Steel Connection Kit ............................................................................24 Microtiter Plate MPG 96.3 ................................................................................24 Microfluidic Chips Microreactor Chips ..........................................................................................25 Cross Channel Chips ........................................................................................25 Micromixer Chips..............................................................................................25 Temperature Control WP-10 and WP-16 Warmed Platforms ..............................................................26 Guide to Microfluidic & Nanofluidic Products | TB-3 CS Thermal Insert ....................................................................................26 CO2 Microscope Stage Incubator ........................................................................26 SH-27B and SF-28 Single Inline Solution Heaters ..................................................27 Perfusion Valve Control Systems ........................................................................27 Specialized Fluidic Products ..................................................................................28-29 Applica tions Reactor/Detector ................................................................................................30 Reactor/Microspheres ..........................................................................................31 Harvard Apparatus Device ............................................................................................................32-34 Detection ............................................................................................................34 Reactor................................................................................................................35 Bibliography ........................................................................................................36-39 Getting to know Harvard Apparatus ............................................................................40 Technical Service ......................................................................................................41 2 phone 508.893.8999 • email [email protected] • web www.harvardapparatus.com Micro/Nanofluidics Introduction Why Miniaturization? Volume of 1µl 1nl 1pl Is a Cube of 1mm3 100µm3 10µm3 # of Molecules 600,000,000 600,000 600 (1nM solution) Diffusion Time 17 min 10 s 100 ms # of Reactions 1.5/min/cm2 250/s/cm2 2,500,000/s/cm2 (diffusion controlled) Source: A. Manz, ISAS Dortmun • 10 Fold Miniaturization • 1000 x smaller volume • 100 x faster separation • 10 x lower reagent Harvard Apparatus • 100 x capillarity consumption The two charts above illustrate why there is so much interest in Micro and Nanofluidics: | Reduced Sample Size: Researchers can use expensive or precious Guide to Microfluidic & Nanofluidic Products reagents in small quantity, reducing expense and allowing for increased research on trace amounts of sample. Decreased Scale of Experimentation: Experiments are easier to automate; easier to do simultaneous multiple experiments in the same physical space as a macro experiment. Increased Experimental Productivity: The ability to automate multiple simultaneous complete experi- ments creates increased experimental productivity. Conclusions: • Study more variables simultaneously per time period • Study smaller phenomenon for greater understanding • Increased experimental productivity • More information faster than conventional techniques phone 508.893.8999 • email [email protected] • web www.harvardapparatus.com 3 Micro/Nanofluidics Introduction Evolution of Research Reactor Both Batch and Continuous Flow Small pl/min Technicon Continuous Flow Sample Size Flow Rate Guide to Microfluidic & Nanofluidic Products | Large Harvard Apparatus ml/min 1950 1960 1970 1980 Years 4 phone 508.893.8999 • email [email protected] • web www.harvardapparatus.com Micro/Nanofluidics Introduction Fluidic Devices Lab-on-a-chip Sensors Tissues Reactors Flow Injection Harvard Apparatus Analysis Continuous Flow | Guide to Microfluidic & Nanofluidic Products Batch Reactors Glassware Reactors 1990 2000 2010 AND BEYOND! Years phone 508.893.8999 • email [email protected] • web www.harvardapparatus.com 5 Micro/Nanofluidics Introduction What do we mean by Micro and Nanofluidics? The science of micro and nanofluidics is the building of miniaturized devices with chambers and tunnels for the containment and flow of fluids. With devices measured at the micrometer level and fluids measured in nanoliters and picoliters, microfluidic and nanofluidic d evices are widely used in the applications shown in this guide (pgs 8 & 9). Photo by Dietrich Kohlheyer of the University of Twente Guide to Microfluidic & Nanofluidic Products | Harvard Apparatus 6 phone 508.893.8999 • email [email protected] • web www.harvardapparatus.com Micro/Nanofluidics Introduction Microfluidics: Nanotechnology provides: (10-6) length scale is on the order of a micron. • Exquisite new tools to engineer novel Liquid micro systems and components differ materials and devices at the nanoscale level, Harvard Apparatus from macro systems primarily due to device A nanometer, one billionth of a meter, is fabrication of miniature systems. about 10,000 times narrower than a human hair Nanofluidics: • Biological systems on the nano scale resem- (10-9) The science of building microminiaturized ble the semiconductor world where a mole- devices with chambers and tunnels for the | cule or a biologica l system is a series of Guide to Microfluidic & Nanofluidic Products containment and flow of fluids measured at the atoms and energies nanometer level. Harvard Apparatus 108 years of experience in low-flow science provides you • Monitoring temperature, pressure, with: low flow (microliter, nanoliter, picoliter and inserting things into a cell or moving fluids femtoliter) fluid delivery systems, with high becomes an exercise in moving atoms and accuracy and precision, pulse free pumping maintaining or monitoring energies mechanisms and
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