Mild Traumatic Brain Injury Disrupts Functional Dynamic Attractors of Healthy Mental States
medRxiv preprint doi: https://doi.org/10.1101/19007906; this version posted October 29, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license . 1 mTBI Disrupts Brain Connectivity Dynamics VM Vergara, HJ van der Horn, AR Mayer, FA Espinoza, J van der Naalt,VD Calhoun Mild Traumatic Brain Injury Disrupts Functional Dynamic Attractors of Healthy Mental States 1Victor M. Vergara, PhD, 2Harm J. van der Horn, MD, PhD, 3Andrew R. Mayer, PhD, 1Flor A. Espinoza, PhD, 2Joukje van der Naalt, MD, PhD 1Vince D Calhoun, PhD 1Tri-institutional center for Translational Research in Neuroimaging and Data Science (TRenDS), [Georgia State University, Georgia Institute of Technology, Emory University], 25 Park Place, Atlanta GA 30303 2Dept of Neurology, University of Groningen, University Medical Center Groningen, The Netherlands 3The Mind Research Network and Lovelace Biomedical and Environmental Research Institute, 1101 Yale Blvd. NE, Albuquerque, New Mexico, 87106 Abstract The human brain has the ability of changing its wiring configuration by increasing or decreasing functional connectivity strength between specific areas. Variable but recurring configuration patterns in dynamic functional connectivity have been observed during resting fMRI experiments, patterns which are defined as dynamic brain states. The question arises whether in a regular healthy brain these states evolve in a random fashion or in a specific sequential order. The current work reveals both the specific state sequence in healthy brains, as well as the set of disruptions in this sequence produced by traumatic brain injury.
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