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Diagnosis, Management, Treatment and Costs of Prostate Cancer in England and Wales Health Technology Assessment 1997; Vol. 1: No. 3 Review The diagnosis, management, treatment and costs of prostate cancer in England and Wales Jocelyn Chamberlain Jane Melia Sue Moss Jackie Brown Health Technology Assessment NHS R&D HTA Programme HTA Standing Group on Health Technology Chair: Professor Sir Miles Irving, Professor of Surgery, University of Manchester, Hope Hospital, Salford † Dr Sheila Adam, Department of Health Professor Howard Glennester, Professor Martin Roland, Professor of Social Science & Professor of General Practice, Professor Martin Buxton, Professor of Administration, London School of University of Manchester Economics, Brunel University † Economics and Political Science Mr Hugh Ross, Chief Executive, Director, Professor Angela Coulter, The United Bristol Healthcare NHS Trust † Kings Fund Centre for Health Services Professor Sir John Grimley Evans, Development † Department of Geriatric Medicine, Professor Ian Russell, Department of Radcliffe Infirmary, Oxford † Health, Sciences & Clinical Evaluation, Professor Anthony Culyer, University of York Deputy Vice-Chancellor, University of York † Mr John H James, Chief Executive, Kensington, Chelsea & Westminster Professor Trevor Sheldon, Director, Dr Peter Doyle, Executive Director, Health Authority NHS Centre for Reviews & Dissemination, Zeneca Ltd, ACOST Committee on Medical University of York † Research & Health Professor Richard Lilford, Professor Mike Smith, Director, † Professor John Farndon, Regional Director, R&D, West Midlands The Research School of Medicine, † † Professor of Surgery, University of Bristol Professor Michael Maisey, Professor of University of Leeds Professor Charles Florey, Radiological Sciences, UMDS, London Dr Charles Swan, Department of Epidemiology & Public Consultant Gastroenterologist, Health, Ninewells Hospital & Medical Dr Jeremy Metters, Deputy Chief North Staffordshire Royal Infirmary Medical Officer, Department of Health † School, University of Dundee † Professor Tom Walley, Department of Professor John Gabbay, Director, Mrs Gloria Oates, Chief Executive, Pharmacological Therapeutics, Wessex Institute for Health Research Oldham NHS Trust University of Liverpool † † & Development Professor Michael Rawlins, Dr Julie Woodin, Chief Excutive, † Dr Tony Hope, The Medical School, Wolfson Unit of Clinical Pharmacology, Nottingham Health Authority University of Oxford † University of Newcastle-upon-Tyne † Current members HTA Commissioning Board Chair: Professor Charles Florey, Department of Epidemiology & Public Health, Ninewells Hospital & Medical School, University of Dundee † Professor Ian Russell, Department of Dr Michael Horlington, Head of Professor David Sackett, Health, Sciences & Clinical Evaluation, Corporate Licensing, Smith & Nephew Centre for Evidence Based Medicine, Oxford * University of York Group Research Centre Dr David Spiegelhalter, Mr Peter Bower, Professor Sir Miles Irving (Programme MRC Biostatistics Unit, Institute of Public Independent Management Consultant, Director), Professor of Surgery, University Health, Cambridge Newcastle-upon-Tyne † of Manchester, Hope Hospital, Salford † Dr Ala Szczepura, Director, Ms Christine Clarke, Director of Professor Martin Knapp, Director, Centre for Health Services Studies, Pharmacy, Hope Hospital, Salford † Personal Social Services Research Unit, University of Warwick † London School of Economics and Professor David Cohen, Political Science Professor Graham Watt, Professor of Health Economics, Department of General Practice, University of Glamorgan Professor Theresa Marteau, Director, Woodside Health Centre, Glasgow † Psychology & Genetics Research Group, Mr Barrie Dowdeswell, UMDS, London Professor David Williams, Chief Executive, Royal Victoria Infirmary, Department of Clinical Engineering, Newcastle-upon-Tyne Professor Sally McIntyre, MRC Medical University of Liverpool Sociology Unit, Glasgow Dr Mike Gill, Brent and Harrow Dr Mark Williams, Health Authority † Professor Jon Nicholl, Director, Medical Public Health Physician, Bristol Care Research Unit, University of Sheffield † Dr Jenny Hewison, Senior Lecturer, * Previous Chair Department of Psychology, University Dr Tim Peters, Department of Social † Current members of Leeds † Medicine, University of Bristol † National Coordinating Centre for Health Technology Assessment, Advisory Group Chair: Professor John Gabbay, Wessex Institute for Health Research & Development Professor Mike Drummond, Centre for Dr Ruairidh Milne, Wessex Institute for Professor Ian Russell, Department of Health Economics, University of York Health Research & Development Health, Sciences & Clinical Evaluation, University of York Professor Charles Florey, Ms Kay Pattison, Research & Department of Epidemiology & Public Health, Development Directorate, NHS Executive Dr Ken Stein, Wessex Institute for Health University of Dundee Research & Development Professor Sir Miles Irving, Professor James Raftery, Health Professor Andrew Stevens, Department of Surgery, Hope Hospital, Salford Economics Unit, University of Birmingham Department of Public Health & Epidemiology, University of Birmingham Ms Lynn Kerridge, Wessex Institute for Dr Paul Roderick, Wessex Institute for Health Research & Development Health Research & Development HTA How to obtain copies of this and other HTA Programme reports. An electronic version of this publication, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (http://www.hta.ac.uk). A fully searchable CD-ROM is also available (see below). Printed copies of HTA monographs cost £20 each (post and packing free in the UK) to both public and private sector purchasers from our Despatch Agents. Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph. You can order HTA monographs from our Despatch Agents: – fax (with credit card or official purchase order) – post (with credit card or official purchase order or cheque) – phone during office hours (credit card only). Additionally the HTA website allows you either to pay securely by credit card or to print out your order and then post or fax it. Contact details are as follows: HTA Despatch Email: [email protected] c/o Direct Mail Works Ltd Tel: 02392 492 000 4 Oakwood Business Centre Fax: 02392 478 555 Downley, HAVANT PO9 2NP, UK Fax from outside the UK: +44 2392 478 555 NHS libraries can subscribe free of charge. Public libraries can subscribe at a very reduced cost of £100 for each volume (normally comprising 30–40 titles). The commercial subscription rate is £300 per volume. Please see our website for details. Subscriptions can only be purchased for the current or forthcoming volume. Payment methods Paying by cheque If you pay by cheque, the cheque must be in pounds sterling, made payable to Direct Mail Works Ltd and drawn on a bank with a UK address. Paying by credit card The following cards are accepted by phone, fax, post or via the website ordering pages: Delta, Eurocard, Mastercard, Solo, Switch and Visa. We advise against sending credit card details in a plain email. Paying by official purchase order You can post or fax these, but they must be from public bodies (i.e. NHS or universities) within the UK. We cannot at present accept purchase orders from commercial companies or from outside the UK. How do I get a copy of HTA on CD? Please use the form on the HTA website (www.hta.ac.uk/htacd.htm). Or contact Direct Mail Works (see contact details above) by email, post, fax or phone. HTA on CD is currently free of charge worldwide. The website also provides information about the HTA Programme and lists the membership of the various committees. The diagnosis, management, treatment and costs of prostate cancer in England and Wales Jocelyn Chamberlain FRCP,FFPHM 1 Jane Melia PhD, Hon MFPHM 1 Sue Moss PhD, Hon MFPHM 1 Jackie Brown PhD 2 1 Cancer Screening Evaluation Unit, Institute of Cancer Research, Section of Epidemiology, D Block, Cotswold Road, Sutton, Surrey SM2 5NG 2 Health Economics Research Group, Brunel University, Uxbridge, Middlesex UB8 3PH Final manuscript received October 1996 This report should be referenced as follows: Chamberlain J, Melia J, Moss S, Brown J.The diagnosis, management, treatment and costs of prostate cancer in England and Wales. Health Technol Assess 1997;1 (3). NHS R&D HTA Programme he overall aim of the NHS R&D Health Technology Assessment (HTA) programme T is to ensure that high-quality research information on the costs, effectiveness and broader impact of health technologies is produced in the most efficient way for those who use, manage and work in the NHS. Research is undertaken in those areas where the evidence will lead to the greatest benefits to patients, either through improved patient outcomes or the most efficient use of NHS resources. The Standing Group on Health Technology advises on national priorities for health technology assessment. Six advisory panels assist the Standing Group in identifying and prioritising projects. These priorities are then considered by the HTA Commissioning Board supported by the National Coordinating Centre for HTA (NCCHTA). This report is one of a series covering acute care, diagnostics and imaging, methodology, pharmaceuticals, population screening, and primary and community care. It was identified as a priority by the Diagnostics and Imaging Panel (see inside back cover). A considered decision was taken to commission two similar reports in
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