Apol1 Pnas Plus
Evolution of the primate trypanolytic factor APOL1 PNAS PLUS Russell Thomsona,1,2, Giulio Genoveseb,c,1, Chelsea Canona,d, Daniella Kovacsicsa,d, Matthew K. Higginse, Mark Carringtonf, Cheryl A. Winklerg, Jeffrey Kopph, Charles Rotimii, Adebowale Adeyemoi, Ayo Doumateyi, George Ayodoj,k, Seth L. Alperb, Martin R. Pollakb,c, David J. Friedmanb,l,4, and Jayne Rapera,d,3,4 aDepartment of Microbiology, New York University School of Medicine, New York, NY 10016; bRenal Division and lCenter for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215; cBroad Institute of Harvard and Massachusetts Institute of Technology, Boston, MA 02215; dDepartment of Biological Sciences, Hunter College at City University of New York, New York, NY 10065; eDepartment Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom; fDepartment of Biochemistry, University of Cambridge, Cambridge CB2 1QW, United Kingdom; gBasic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Leidos Biomedical Research, Inc., Frederick National Laboratory, Frederick, MD 21702; hKidney Disease Section, National Institutes of Health, Bethesda, MD 20892; iCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892; jKenya Medical Research Institute, Kisumu, Kenya; and kDivision of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55454 Edited by Paul T. Englund, Johns Hopkins University, Baltimore, MD, and approved April 8, 2014 (received for review January 15, 2014) ApolipoproteinL1 (APOL1) protects humans and some primates against Trypanosoma brucei brucei, whereas baboon sera protect against several African trypanosomes. APOL1 genetic variants against T. b. brucei, Trypanosoma brucei rhodesiense, and po- strongly associated with kidney disease in African Americans have tentially, Trypanosoma brucei gambiense (8, 9).
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